EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
25353388	Identification of HERC5 and its potential role in NSCLC progression.	Int J Cancer	2015 May 15	Wrage M	doi: 10.1002/ijc.29298
26653219	HERC5 is a prognostic biomarker for post-liver transplant recurrent human hepatocellular carcinoma.	J Transl Med	2015 Dec 11	Xue F	doi: 10.1186/s12967-015-0743-2.

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr4	88469199	Missense_Mutation	NA	E393K	0.35
BLCA	chr4	88463941	Silent	NA	V289V	0.21
BLCA	chr4	88489309	Missense_Mutation	novel	E702D	0.46
BLCA	chr4	88493065	Missense_Mutation	NA	F729L	0.49
BLCA	chr4	88494235	Frame_Shift_Del	novel	*A784Pfs23**	0.27
BLCA	chr4	88494241	Missense_Mutation	novel	N785S	0.09
BLCA	chr4	88486193	Missense_Mutation	novel	E606Q	0.22
BRCA	chr4	88475945	Missense_Mutation	novel	M499I	0.27
BRCA	chr4	88462263	Nonsense_Mutation	novel	G199*	0.38
BRCA	chr4	88469241	Missense_Mutation	rs145240865	R407W	0.2
BRCA	chr4	88467189	Missense_Mutation	novel	E348K	0.19
BRCA	chr4	88467181	Nonsense_Mutation	NA	S345*	0.27
BRCA	chr4	88489316	Missense_Mutation	NA	D705H	0.22
BRCA	chr4	88467181	Nonsense_Mutation	NA	S345*	0.27
CESC	chr4	88505846	Missense_Mutation	rs751293985	E1015K	0.38
CESC	chr4	88479502	Missense_Mutation	novel	H578Y	0.06
CESC	chr4	88494271	Missense_Mutation	NA	K795T	0.1
CESC	chr4	88487104	Missense_Mutation	novel	F629L	0.37
CESC	chr4	88487096	Missense_Mutation	rs148569726	V627I	0.33
CESC	chr4	88504285	Missense_Mutation	rs773827213	A879V	0.63
CESC	chr4	88504556	Missense_Mutation	NA	A943G	0.31
CESC	chr4	88504325	Silent	rs201540163	C892C	0.16
CESC	chr4	88499948	Missense_Mutation	NA	D823N	0.29
CESC	chr4	88476019	Missense_Mutation	rs766394501	S524L	0.36
CESC	chr4	88486168	Silent	NA	L597L	0.61
COAD	chr4	88475992	Missense_Mutation	NA	V515G	0.38
COAD	chr4	88494309	Nonsense_Mutation	NA	E808*	0.25
COAD	chr4	88487071	Splice_Region	rs369956338	D618D	0.16
COAD	chr4	88504283	Missense_Mutation	NA	K878N	0.26
COAD	chr4	88487096	Missense_Mutation	rs148569726	V627I	0.2
COAD	chr4	88463598	Missense_Mutation	novel	G252D	0.2
COAD	chr4	88460121	Missense_Mutation	rs779976280	K139I	0.83
COAD	chr4	88487095	Silent	rs111323592	C626C	0.25
COAD	chr4	88504286	Silent	rs761284663	A879A	0.35
COAD	chr4	88469179	Missense_Mutation	NA	R386M	0.3
COAD	chr4	88504271	Silent	rs762515665	N874N	0.45
COAD	chr4	88467091	Missense_Mutation	NA	G315E	0.27
COAD	chr4	88487096	Missense_Mutation	rs148569726	V627I	0.29
COAD	chr4	88467095	Missense_Mutation	novel	K316N	0.39
COAD	chr4	88486186	Missense_Mutation	NA	F603L	0.25
COAD	chr4	88470659	Frame_Shift_Del	NA	L430*	0.4
COAD	chr4	88459471	Splice_Site	NA	X130_splice	0.55
COAD	chr4	88504313	Missense_Mutation	NA	F888L	0.34
DLBC	chr4	88505851	Silent	rs756694449	A1016A	0.39
GBM	chr4	88489271	Missense_Mutation	novel	L690V	0.05
GBM	chr4	88460100	Missense_Mutation	novel	E132V	0.19
GBM	chr4	88486163	Missense_Mutation	rs369280809	E596K	0.28
GBM	chr4	88489208	Missense_Mutation	rs754363045	E669K	0.33
GBM	chr4	88494204	Missense_Mutation	novel	L773I	0.22
GBM	chr4	88469188	Missense_Mutation	novel	P389L	0.1
GBM	chr4	88469156	Splice_Site	novel	X379_splice	0.12
GBM	chr4	88505850	Missense_Mutation	novel	A1016V	0.47
GBM	chr4	88489268	Missense_Mutation	novel	H689D	0.05
HNSC	chr4	88493035	Silent	novel	G719G	0.2
HNSC	chr4	88505756	Missense_Mutation	novel	E985K	0.22
HNSC	chr4	88486192	Silent	novel	V605V	0.29
HNSC	chr4	88486225	Silent	NA	T616T	0.28
HNSC	chr4	88486226	Missense_Mutation	novel	V617L	0.26
HNSC	chr4	88499951	Missense_Mutation	novel	E824Q	0.21
HNSC	chr4	88479481	Missense_Mutation	novel	L571V	0.23
HNSC	chr4	88479402	Silent	novel	Q544Q	0.1
KICH	chr4	88487071	Splice_Region	rs369956338	D618D	0.4
KIRC	chr4	88504340	Silent	NA	I897I	0.08
KIRC	chr4	88462353	Missense_Mutation	NA	E229K	0.33
KIRC	chr4	88505852	Missense_Mutation	novel	I1017V	0.27
KIRC	chr4	88463869	Missense_Mutation	NA	F265L	0.26
KIRP	chr4	88489258	Silent	NA	V685V	0.45
LGG	chr4	88489229	Missense_Mutation	rs376568622	A676T	0.42
LGG	chr4	88504501	Missense_Mutation	novel	R925C	0.36
LUAD	chr4	88487096	Missense_Mutation	rs148569726	V627I	0.38
LUAD	chr4	88467089	Frame_Shift_Del	novel	*G315Efs23**	0.28
LUAD	chr4	88459467	In_Frame_Ins	novel	L129_R130insGKIS	0.07
LUAD	chr4	88489167	Missense_Mutation	NA	S655T	0.32
LUAD	chr4	88472406	Splice_Region	novel		0.27
LUAD	chr4	88462236	Missense_Mutation	NA	G190R	0.21
LUAD	chr4	88494316	Missense_Mutation	NA	S810T	0.61
LUAD	chr4	88505986	3'UTR	novel		1
LUAD	chr4	88489164	Splice_Site	NA	X655_splice	0.24
LUAD	chr4	88459449	Missense_Mutation	rs533028212	N123S	0.31
LUAD	chr4	88493010	Splice_Site	novel	X712_splice	0.12
LUAD	chr4	88504272	Missense_Mutation	novel	D875H	0.13
LUAD	chr4	88462239	Missense_Mutation	novel	V191L	0.42
LUSC	chr4	88479416	Missense_Mutation	novel	A549V	0.29
LUSC	chr4	88463540	Missense_Mutation	novel	D233Y	0.21
LUSC	chr4	88463853	Splice_Site	NA	X261_splice	0.23
LUSC	chr4	88463560	Silent	novel	G239G	0.11
LUSC	chr4	88504332	Missense_Mutation	NA	D895H	0.06
LUSC	chr4	88479426	Nonsense_Mutation	NA	C552*	0.23
LUSC	chr4	88505877	Nonstop_Mutation	NA	1025Lext30	0.24
LUSC	chr4	88463540	Missense_Mutation	novel	D233Y	0.1
LUSC	chr4	88462338	Missense_Mutation	NA	G224S	0.29
LUSC	chr4	88476027	Missense_Mutation	NA	L527M	0.49
LUSC	chr4	88479364	Missense_Mutation	NA	A532T	0.32
LUSC	chr4	88460160	Missense_Mutation	novel	A152V	0.67
OV	chr4	88486225	Silent	NA	T616T	0.88
OV	chr4	88504302	Missense_Mutation	NA	R885W	0.23
OV	chr4	88463973	Missense_Mutation	novel	I300T	0.04
PAAD	chr4	88493098	Silent	rs781638920	P740P	0.09
PAAD	chr4	88504303	Missense_Mutation	rs375430185	R885Q	0.18
READ	chr4	88504302	Missense_Mutation	NA	R885W	0.29
READ	chr4	88504285	Missense_Mutation	rs773827213	A879V	0.25
READ	chr4	88504371	Missense_Mutation	NA	V908L	0.4
READ	chr4	88479376	Nonsense_Mutation	novel	E536*	0.43
READ	chr4	88486168	Silent	rs774593839	L597L	0.36
READ	chr4	88487114	Missense_Mutation	novel	P633S	0.37
READ	chr4	88489326	Missense_Mutation	NA	K708T	0.31
SARC	chr4	88504332	Missense_Mutation	NA	D895H	0.06
SARC	chr4	88463882	Missense_Mutation	novel	G270R	0.39
SKCM	chr4	88463547	Missense_Mutation	rs756900772	S235F	0.19
SKCM	chr4	88494162	Splice_Region	novel		0.65
SKCM	chr4	88494300	Missense_Mutation	NA	D805N	0.11
SKCM	chr4	88499940	Missense_Mutation	NA	L820H	0.41
SKCM	chr4	88494219	Silent	novel	L778L	0.42
SKCM	chr4	88493038	Nonsense_Mutation	NA	Y720*	0.7
SKCM	chr4	88469199	Missense_Mutation	NA	E393K	0.28
SKCM	chr4	88468370	Nonsense_Mutation	NA	L361*	0.62
SKCM	chr4	88463549	Missense_Mutation	NA	L236F	0.17
SKCM	chr4	88463548	Silent	NA	S235S	0.14
SKCM	chr4	88457471	Missense_Mutation	NA	R68C	0.31
SKCM	chr4	88469161	Missense_Mutation	NA	S380L	0.59
SKCM	chr4	88469187	Missense_Mutation	NA	P389S	0.34
SKCM	chr4	88487136	Missense_Mutation	rs772009697	S640L	0.31
SKCM	chr4	88472452	Missense_Mutation	novel	A448T	0.59
STAD	chr4	88459362	Frame_Shift_Ins	novel	*N96Kfs25**	0.23
STAD	chr4	88486183	Frame_Shift_Del	NA	*F604Lfs2**	0.26
STAD	chr4	88489260	Missense_Mutation	novel	R686I	0.12
STAD	chr4	88463961	Missense_Mutation	NA	R296K	0.41
STAD	chr4	88494288	Missense_Mutation	NA	P801S	0.13
STAD	chr4	88487071	Splice_Region	rs369956338	D618D	0.19
STAD	chr4	88467164	Silent	rs778841083	P339P	0.33
STAD	chr4	88459415	Missense_Mutation	NA	L112I	0.31
STAD	chr4	88469161	Nonsense_Mutation	NA	S380*	0.25
STAD	chr4	88463614	Silent	NA	L257L	0.08
STAD	chr4	88467181	Missense_Mutation	NA	S345L	0.21
STAD	chr4	88494285	Missense_Mutation	NA	M800V	0.31
STAD	chr4	88459373	Missense_Mutation	NA	K98E	0.21
STAD	chr4	88504374	Missense_Mutation	novel	I909V	0.44
STAD	chr4	88504306	Missense_Mutation	novel	R886I	0.46
STAD	chr4	88493097	Missense_Mutation	rs189534383	P740L	0.27
STAD	chr4	88460115	Frame_Shift_Del	rs770854785	I140*	0.38
STAD	chr4	88486183	Frame_Shift_Del	NA	*F604Lfs2**	0.39
STAD	chr4	88504355	Silent	rs771189296	P902P	0.29
STAD	chr4	88504273	Missense_Mutation	NA	D875G	0.16
TGCT	chr4	88467085	Missense_Mutation	novel	D313G	0.07
THCA	chr4	88470648	In_Frame_Ins	novel	L425_T426insLSVCIL	0.06
UCEC	chr4	88462195	Missense_Mutation	NA	F176C	0.45
UCEC	chr4	88505839	Silent	rs376617022	A1012A	0.27
UCEC	chr4	88463967	Missense_Mutation	novel	T298N	0.43
UCEC	chr4	88472490	Missense_Mutation	novel	W460C	0.44
UCEC	chr4	88504371	Missense_Mutation	novel	V908M	0.4
UCEC	chr4	88486168	Silent	rs774593839	L597L	0.09
UCEC	chr4	88487132	Missense_Mutation	NA	L639M	0.41
UCEC	chr4	88494311	Silent	NA	E808E	0.41
UCEC	chr4	88475973	Missense_Mutation	novel	V509M	0.46
UCEC	chr4	88505971	3'UTR	novel		0.34
UCEC	chr4	88463543	Missense_Mutation	novel	P234T	0.25
UCEC	chr4	88462341	Missense_Mutation	NA	L225M	0.28
UCEC	chr4	88470640	Missense_Mutation	NA	P422H	0.13
UCEC	chr4	88472419	Missense_Mutation	novel	E437K	0.05
UCEC	chr4	88486210	Silent	NA	Y611Y	0.24
UCEC	chr4	88487132	Missense_Mutation	NA	L639M	0.04
UCEC	chr4	88505838	Missense_Mutation	rs752546199	A1012V	0.19
UCEC	chr4	88487086	Silent	NA	V623V	0.36
UCEC	chr4	88504302	Missense_Mutation	NA	R885W	0.28
UCEC	chr4	88504325	Silent	rs201540163	C892C	0.27
UCEC	chr4	88504328	Silent	rs750432822	D893D	0.46
UCEC	chr4	88472419	Nonsense_Mutation	novel	E437*	0.28
UCEC	chr4	88486168	Silent	rs774593839	L597L	0.14
UCEC	chr4	88463875	Silent	rs111923801	F267F	0.44
UCEC	chr4	88504302	Missense_Mutation	NA	R885W	0.38
UCEC	chr4	88459362	Frame_Shift_Ins	novel	*N96Kfs25**	0.44
UCEC	chr4	88487095	Silent	rs111323592	C626C	0.19
UCEC	chr4	88499962	Silent	rs376687144	N827N	0.4
UCEC	chr4	88486183	Frame_Shift_Del	NA	*F604Lfs2**	0.48
UCEC	chr4	88486163	Missense_Mutation	rs369280809	E596K	0.37
UCEC	chr4	88462143	Missense_Mutation	novel	L159I	0.38
UCEC	chr4	88475915	Missense_Mutation	novel	I489M	0.31
UCEC	chr4	88499988	Missense_Mutation	novel	F836C	0.4
UCEC	chr4	88468366	Missense_Mutation	novel	E360K	0.42
UCEC	chr4	88462162	Missense_Mutation	novel	N165S	0.15
UCEC	chr4	88499942	Missense_Mutation	novel	L821M	0.11
UCEC	chr4	88504246	Missense_Mutation	novel	S866Y	0.12
UCEC	chr4	88469183	Silent	novel	T387T	0.29
UCEC	chr4	88487122	Silent	novel	I635I	0.44
UCEC	chr4	88486187	Missense_Mutation	novel	F604V	0.48
UCEC	chr4	88489228	Silent	rs758486816	F675F	0.42
UCEC	chr4	88475890	Missense_Mutation	novel	S481Y	0.44
UCEC	chr4	88468350	Silent	NA	S354S	0.42
UCEC	chr4	88494191	Missense_Mutation	novel	F768L	0.06
UCEC	chr4	88487137	Silent	rs182842130	S640S	0.24
UCEC	chr4	88463970	Missense_Mutation	novel	Q299R	0.35
UCEC	chr4	88494212	Silent	NA	G775G	0.28
UCEC	chr4	88504414	Missense_Mutation	novel	K922R	0.14
UCEC	chr4	88475878	Missense_Mutation	NA	L477R	0.44
UCEC	chr4	88499942	Silent	NA	L821L	0.39
UCEC	chr4	88494184	Missense_Mutation	NA	R766I	0.27
UCEC	chr4	88470626	Missense_Mutation	novel	E417D	0.05
UCEC	chr4	88459415	Missense_Mutation	NA	L112I	0.26
UCEC	chr4	88462247	Silent	novel	L193L	0.1
UCEC	chr4	88472434	Missense_Mutation	novel	Y442H	0.23
UCEC	chr4	88487096	Missense_Mutation	rs148569726	V627I	0.26
UCEC	chr4	88504515	Silent	novel	G929G	0.22
UCEC	chr4	88493065	Missense_Mutation	NA	F729L	0.4
UCEC	chr4	88489228	Silent	rs758486816	F675F	0.24
UCEC	chr4	88504325	Silent	rs201540163	C892C	0.38
UCEC	chr4	88505742	Missense_Mutation	novel	P980H	0.27
UCEC	chr4	88479361	Missense_Mutation	novel	W531R	0.4
UCEC	chr4	88489229	Missense_Mutation	rs376568622	A676T	0.35

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
LIHC	DEL	0.4216	3.0903e-07
LUAD	DEL	0.188	0.050802
MESO	DEL	0.4023	0.075661

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.0026	Kaplan-Meier Survival Analysis
STAD	0.021	Kaplan-Meier Survival Analysis
MESO	0.00027	Kaplan-Meier Survival Analysis
SKCM	0.037	Kaplan-Meier Survival Analysis
PRAD	0.034	Kaplan-Meier Survival Analysis
ESCA	0.045	Kaplan-Meier Survival Analysis
CESC	0.0065	Kaplan-Meier Survival Analysis
UCEC	0.0001	Kaplan-Meier Survival Analysis
THCA	0.046	Kaplan-Meier Survival Analysis
UVM	0.0016	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Gene Ontology

Description

Ensembl ID: ENSG00000138646 (Gene tree)
Gene ID: 51191
Gene Symbol: HERC5
Alias: CEB1
Full Name: HECT and RLD domain containing E3 ubiquitin protein ligase 5
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 49,054 bases
Position: chr4:88,457,117-88,506,170
Accession: 24368
RBP type: non-canonical RBP
Summary: This gene is a member of the HERC family of ubiquitin ligases and encodes a protein with a HECT domain and five RCC1 repeats. Pro-inflammatory cytokines upregulate expression of this gene in endothelial cells. The protein localizes to the cytoplasm and perinuclear region and functions as an interferon-induced E3 protein ligase that mediates ISGylation of protein targets. The gene lies in a cluster of HERC family genes on chromosome 4. [provided by RefSeq, Jul 2008]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	RIC & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30352994	Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome capture	RIC & Jurkat	2018 Oct 23	Perez-Perri JI	DOI:10.1038/s41467-018-06557-8

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000508695	HERC5-204	543	-	-	- (aa)	-	-
ENST00000510223	HERC5-205	2925	-	-	- (aa)	-	-
ENST00000264350	HERC5-201	3513	XM_011532022	ENSP00000264350	1024 (aa)	XP_011530324	Q9UII4
ENST00000502913	HERC5-202	1949	-	-	- (aa)	-	-
ENST00000508159	HERC5-203	2243	-	ENSP00000424129	662 (aa)	-	E9PBL0

Gene Model

Click here to download ENSG00000138646's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000138646	Hypertension	2.6003624E-005	-
ENSG00000138646	Forced Expiratory Volume	9E-6	22424883

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000138646	rs10516809	4	88499935	?	Pulmonary function decline	22424883	[0.17-0.44] unit increase	0.3063	EFO_0004314

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000138646's network

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000079	regulation of cyclin-dependent protein serine/threonine kinase activity	10581175.	TAS	Process
GO:0000209	protein polyubiquitination	-	TAS	Process
GO:0003723	RNA binding	22658674.	HDA	Function
GO:0004842	ubiquitin-protein transferase activity	-	TAS	Function
GO:0005515	protein binding	20133869.20308324.	IPI	Function
GO:0005829	cytosol	-	TAS	Component
GO:0032020	ISG15-protein conjugation	21873635.	IBA	Process
GO:0032020	ISG15-protein conjugation	20308324.	IDA	Process
GO:0032480	negative regulation of type I interferon production	-	TAS	Process
GO:0042296	ISG15 transferase activity	21873635.	IBA	Function
GO:0042296	ISG15 transferase activity	20308324.	IDA	Function
GO:0045087	innate immune response	-	IEA	Process
GO:0048471	perinuclear region of cytoplasm	-	IEA	Component
GO:0050688	regulation of defense response to virus	21873635.	IBA	Process
GO:0050688	regulation of defense response to virus	20308324.	IDA	Process
GO:0051607	defense response to virus	-	IEA	Process

EuRBPDB

Note: to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.