EuRBPDB

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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
25353388Identification of HERC5 and its potential role in NSCLC progression.Int J Cancer2015 May 15Wrage Mdoi: 10.1002/ijc.29298
26653219HERC5 is a prognostic biomarker for post-liver transplant recurrent human hepatocellular carcinoma.J Transl Med2015 Dec 11Xue Fdoi: 10.1186/s12967-015-0743-2.

Differential Expression

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
BLCAchr488469199Missense_MutationNAE393K0.35
BLCAchr488463941SilentNAV289V0.21
BLCAchr488489309Missense_MutationnovelE702D0.46
BLCAchr488493065Missense_MutationNAF729L0.49
BLCAchr488494235Frame_Shift_DelnovelA784Pfs*230.27
BLCAchr488494241Missense_MutationnovelN785S0.09
BLCAchr488486193Missense_MutationnovelE606Q0.22
BRCAchr488475945Missense_MutationnovelM499I0.27
BRCAchr488462263Nonsense_MutationnovelG199*0.38
BRCAchr488469241Missense_Mutationrs145240865R407W0.2
BRCAchr488467189Missense_MutationnovelE348K0.19
BRCAchr488467181Nonsense_MutationNAS345*0.27
BRCAchr488489316Missense_MutationNAD705H0.22
BRCAchr488467181Nonsense_MutationNAS345*0.27
CESCchr488505846Missense_Mutationrs751293985E1015K0.38
CESCchr488479502Missense_MutationnovelH578Y0.06
CESCchr488494271Missense_MutationNAK795T0.1
CESCchr488487104Missense_MutationnovelF629L0.37
CESCchr488487096Missense_Mutationrs148569726V627I0.33
CESCchr488504285Missense_Mutationrs773827213A879V0.63
CESCchr488504556Missense_MutationNAA943G0.31
CESCchr488504325Silentrs201540163C892C0.16
CESCchr488499948Missense_MutationNAD823N0.29
CESCchr488476019Missense_Mutationrs766394501S524L0.36
CESCchr488486168SilentNAL597L0.61
COADchr488475992Missense_MutationNAV515G0.38
COADchr488494309Nonsense_MutationNAE808*0.25
COADchr488487071Splice_Regionrs369956338D618D0.16
COADchr488504283Missense_MutationNAK878N0.26
COADchr488487096Missense_Mutationrs148569726V627I0.2
COADchr488463598Missense_MutationnovelG252D0.2
COADchr488460121Missense_Mutationrs779976280K139I0.83
COADchr488487095Silentrs111323592C626C0.25
COADchr488504286Silentrs761284663A879A0.35
COADchr488469179Missense_MutationNAR386M0.3
COADchr488504271Silentrs762515665N874N0.45
COADchr488467091Missense_MutationNAG315E0.27
COADchr488487096Missense_Mutationrs148569726V627I0.29
COADchr488467095Missense_MutationnovelK316N0.39
COADchr488486186Missense_MutationNAF603L0.25
COADchr488470659Frame_Shift_DelNAL430*0.4
COADchr488459471Splice_SiteNAX130_splice0.55
COADchr488504313Missense_MutationNAF888L0.34
DLBCchr488505851Silentrs756694449A1016A0.39
GBMchr488489271Missense_MutationnovelL690V0.05
GBMchr488460100Missense_MutationnovelE132V0.19
GBMchr488486163Missense_Mutationrs369280809E596K0.28
GBMchr488489208Missense_Mutationrs754363045E669K0.33
GBMchr488494204Missense_MutationnovelL773I0.22
GBMchr488469188Missense_MutationnovelP389L0.1
GBMchr488469156Splice_SitenovelX379_splice0.12
GBMchr488505850Missense_MutationnovelA1016V0.47
GBMchr488489268Missense_MutationnovelH689D0.05
HNSCchr488493035SilentnovelG719G0.2
HNSCchr488505756Missense_MutationnovelE985K0.22
HNSCchr488486192SilentnovelV605V0.29
HNSCchr488486225SilentNAT616T0.28
HNSCchr488486226Missense_MutationnovelV617L0.26
HNSCchr488499951Missense_MutationnovelE824Q0.21
HNSCchr488479481Missense_MutationnovelL571V0.23
HNSCchr488479402SilentnovelQ544Q0.1
KICHchr488487071Splice_Regionrs369956338D618D0.4
KIRCchr488504340SilentNAI897I0.08
KIRCchr488462353Missense_MutationNAE229K0.33
KIRCchr488505852Missense_MutationnovelI1017V0.27
KIRCchr488463869Missense_MutationNAF265L0.26
KIRPchr488489258SilentNAV685V0.45
LGGchr488489229Missense_Mutationrs376568622A676T0.42
LGGchr488504501Missense_MutationnovelR925C0.36
LUADchr488487096Missense_Mutationrs148569726V627I0.38
LUADchr488467089Frame_Shift_DelnovelG315Efs*230.28
LUADchr488459467In_Frame_InsnovelL129_R130insGKIS0.07
LUADchr488489167Missense_MutationNAS655T0.32
LUADchr488472406Splice_Regionnovel0.27
LUADchr488462236Missense_MutationNAG190R0.21
LUADchr488494316Missense_MutationNAS810T0.61
LUADchr4885059863'UTRnovel1
LUADchr488489164Splice_SiteNAX655_splice0.24
LUADchr488459449Missense_Mutationrs533028212N123S0.31
LUADchr488493010Splice_SitenovelX712_splice0.12
LUADchr488504272Missense_MutationnovelD875H0.13
LUADchr488462239Missense_MutationnovelV191L0.42
LUSCchr488479416Missense_MutationnovelA549V0.29
LUSCchr488463540Missense_MutationnovelD233Y0.21
LUSCchr488463853Splice_SiteNAX261_splice0.23
LUSCchr488463560SilentnovelG239G0.11
LUSCchr488504332Missense_MutationNAD895H0.06
LUSCchr488479426Nonsense_MutationNAC552*0.23
LUSCchr488505877Nonstop_MutationNA*1025Lext*300.24
LUSCchr488463540Missense_MutationnovelD233Y0.1
LUSCchr488462338Missense_MutationNAG224S0.29
LUSCchr488476027Missense_MutationNAL527M0.49
LUSCchr488479364Missense_MutationNAA532T0.32
LUSCchr488460160Missense_MutationnovelA152V0.67
OVchr488486225SilentNAT616T0.88
OVchr488504302Missense_MutationNAR885W0.23
OVchr488463973Missense_MutationnovelI300T0.04
PAADchr488493098Silentrs781638920P740P0.09
PAADchr488504303Missense_Mutationrs375430185R885Q0.18
READchr488504302Missense_MutationNAR885W0.29
READchr488504285Missense_Mutationrs773827213A879V0.25
READchr488504371Missense_MutationNAV908L0.4
READchr488479376Nonsense_MutationnovelE536*0.43
READchr488486168Silentrs774593839L597L0.36
READchr488487114Missense_MutationnovelP633S0.37
READchr488489326Missense_MutationNAK708T0.31
SARCchr488504332Missense_MutationNAD895H0.06
SARCchr488463882Missense_MutationnovelG270R0.39
SKCMchr488463547Missense_Mutationrs756900772S235F0.19
SKCMchr488494162Splice_Regionnovel0.65
SKCMchr488494300Missense_MutationNAD805N0.11
SKCMchr488499940Missense_MutationNAL820H0.41
SKCMchr488494219SilentnovelL778L0.42
SKCMchr488493038Nonsense_MutationNAY720*0.7
SKCMchr488469199Missense_MutationNAE393K0.28
SKCMchr488468370Nonsense_MutationNAL361*0.62
SKCMchr488463549Missense_MutationNAL236F0.17
SKCMchr488463548SilentNAS235S0.14
SKCMchr488457471Missense_MutationNAR68C0.31
SKCMchr488469161Missense_MutationNAS380L0.59
SKCMchr488469187Missense_MutationNAP389S0.34
SKCMchr488487136Missense_Mutationrs772009697S640L0.31
SKCMchr488472452Missense_MutationnovelA448T0.59
STADchr488459362Frame_Shift_InsnovelN96Kfs*250.23
STADchr488486183Frame_Shift_DelNAF604Lfs*20.26
STADchr488489260Missense_MutationnovelR686I0.12
STADchr488463961Missense_MutationNAR296K0.41
STADchr488494288Missense_MutationNAP801S0.13
STADchr488487071Splice_Regionrs369956338D618D0.19
STADchr488467164Silentrs778841083P339P0.33
STADchr488459415Missense_MutationNAL112I0.31
STADchr488469161Nonsense_MutationNAS380*0.25
STADchr488463614SilentNAL257L0.08
STADchr488467181Missense_MutationNAS345L0.21
STADchr488494285Missense_MutationNAM800V0.31
STADchr488459373Missense_MutationNAK98E0.21
STADchr488504374Missense_MutationnovelI909V0.44
STADchr488504306Missense_MutationnovelR886I0.46
STADchr488493097Missense_Mutationrs189534383P740L0.27
STADchr488460115Frame_Shift_Delrs770854785I140*0.38
STADchr488486183Frame_Shift_DelNAF604Lfs*20.39
STADchr488504355Silentrs771189296P902P0.29
STADchr488504273Missense_MutationNAD875G0.16
TGCTchr488467085Missense_MutationnovelD313G0.07
THCAchr488470648In_Frame_InsnovelL425_T426insLSVCIL0.06
UCECchr488462195Missense_MutationNAF176C0.45
UCECchr488505839Silentrs376617022A1012A0.27
UCECchr488463967Missense_MutationnovelT298N0.43
UCECchr488472490Missense_MutationnovelW460C0.44
UCECchr488504371Missense_MutationnovelV908M0.4
UCECchr488486168Silentrs774593839L597L0.09
UCECchr488487132Missense_MutationNAL639M0.41
UCECchr488494311SilentNAE808E0.41
UCECchr488475973Missense_MutationnovelV509M0.46
UCECchr4885059713'UTRnovel0.34
UCECchr488463543Missense_MutationnovelP234T0.25
UCECchr488462341Missense_MutationNAL225M0.28
UCECchr488470640Missense_MutationNAP422H0.13
UCECchr488472419Missense_MutationnovelE437K0.05
UCECchr488486210SilentNAY611Y0.24
UCECchr488487132Missense_MutationNAL639M0.04
UCECchr488505838Missense_Mutationrs752546199A1012V0.19
UCECchr488487086SilentNAV623V0.36
UCECchr488504302Missense_MutationNAR885W0.28
UCECchr488504325Silentrs201540163C892C0.27
UCECchr488504328Silentrs750432822D893D0.46
UCECchr488472419Nonsense_MutationnovelE437*0.28
UCECchr488486168Silentrs774593839L597L0.14
UCECchr488463875Silentrs111923801F267F0.44
UCECchr488504302Missense_MutationNAR885W0.38
UCECchr488459362Frame_Shift_InsnovelN96Kfs*250.44
UCECchr488487095Silentrs111323592C626C0.19
UCECchr488499962Silentrs376687144N827N0.4
UCECchr488486183Frame_Shift_DelNAF604Lfs*20.48
UCECchr488486163Missense_Mutationrs369280809E596K0.37
UCECchr488462143Missense_MutationnovelL159I0.38
UCECchr488475915Missense_MutationnovelI489M0.31
UCECchr488499988Missense_MutationnovelF836C0.4
UCECchr488468366Missense_MutationnovelE360K0.42
UCECchr488462162Missense_MutationnovelN165S0.15
UCECchr488499942Missense_MutationnovelL821M0.11
UCECchr488504246Missense_MutationnovelS866Y0.12
UCECchr488469183SilentnovelT387T0.29
UCECchr488487122SilentnovelI635I0.44
UCECchr488486187Missense_MutationnovelF604V0.48
UCECchr488489228Silentrs758486816F675F0.42
UCECchr488475890Missense_MutationnovelS481Y0.44
UCECchr488468350SilentNAS354S0.42
UCECchr488494191Missense_MutationnovelF768L0.06
UCECchr488487137Silentrs182842130S640S0.24
UCECchr488463970Missense_MutationnovelQ299R0.35
UCECchr488494212SilentNAG775G0.28
UCECchr488504414Missense_MutationnovelK922R0.14
UCECchr488475878Missense_MutationNAL477R0.44
UCECchr488499942SilentNAL821L0.39
UCECchr488494184Missense_MutationNAR766I0.27
UCECchr488470626Missense_MutationnovelE417D0.05
UCECchr488459415Missense_MutationNAL112I0.26
UCECchr488462247SilentnovelL193L0.1
UCECchr488472434Missense_MutationnovelY442H0.23
UCECchr488487096Missense_Mutationrs148569726V627I0.26
UCECchr488504515SilentnovelG929G0.22
UCECchr488493065Missense_MutationNAF729L0.4
UCECchr488489228Silentrs758486816F675F0.24
UCECchr488504325Silentrs201540163C892C0.38
UCECchr488505742Missense_MutationnovelP980H0.27
UCECchr488479361Missense_MutationnovelW531R0.4
UCECchr488489229Missense_Mutationrs376568622A676T0.35

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
LIHCDEL0.42163.0903e-07
LUADDEL0.1880.050802
MESODEL0.40230.075661

Survival Analysis
CancerP-value Q-value
KIRC0.0026

Kaplan-Meier Survival Analysis

STAD0.021

Kaplan-Meier Survival Analysis

MESO0.00027

Kaplan-Meier Survival Analysis

SKCM0.037

Kaplan-Meier Survival Analysis

PRAD0.034

Kaplan-Meier Survival Analysis

ESCA0.045

Kaplan-Meier Survival Analysis

CESC0.0065

Kaplan-Meier Survival Analysis

UCEC0.0001

Kaplan-Meier Survival Analysis

THCA0.046

Kaplan-Meier Survival Analysis

UVM0.0016

Kaplan-Meier Survival Analysis

Drugs

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Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBPome
  • Expression
  • Transcripts
  • Gene Model
  • Phenotypes
  • GWAS
  • PPI
  • Gene Ontology
Description
Ensembl ID
ENSG00000138646 (Gene tree)
Gene ID
51191
Gene Symbol
HERC5
Alias
CEB1
Full Name
HECT and RLD domain containing E3 ubiquitin protein ligase 5
Gene Type
protein_coding
Species
Homo_sapiens
Status
putative
Strand
Plus strand
Length
49,054 bases
Position
chr4:88,457,117-88,506,170
Accession
24368
RBP type
non-canonical RBP
Summary
This gene is a member of the HERC family of ubiquitin ligases and encodes a protein with a HECT domain and five RCC1 repeats. Pro-inflammatory cytokines upregulate expression of this gene in endothelial cells. The protein localizes to the cytoplasm and perinuclear region and functions as an interferon-induced E3 protein ligase that mediates ISGylation of protein targets. The gene lies in a cluster of HERC family genes on chromosome 4. [provided by RefSeq, Jul 2008]
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & HEK2932018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
29431736Capturing the interactome of newly transcribed RNARIC & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
22658674Insights into RNA biology from an atlas of mammalian mRNA-binding proteinsRIC & Hela2012 May 31Castello ADOI: 10.1016/j.cell.2012.04.031
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & Hela2018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & MCF72018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30352994Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome captureRIC & Jurkat2018 Oct 23Perez-Perri JIDOI:10.1038/s41467-018-06557-8
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000508695HERC5-204543--- (aa)--
ENST00000510223HERC5-2052925--- (aa)--
ENST00000264350HERC5-2013513XM_011532022ENSP000002643501024 (aa)XP_011530324Q9UII4
ENST00000502913HERC5-2021949--- (aa)--
ENST00000508159HERC5-2032243-ENSP00000424129662 (aa)-E9PBL0
Gene Model
Click here to download ENSG00000138646's gene model file
Phenotypes
ensgIDTraitpValuePubmed ID
ENSG00000138646Hypertension2.6003624E-005-
ENSG00000138646Forced Expiratory Volume9E-622424883
GWAS
ensgIDSNPChromosomePositionSNP-risk TraitPubmedID95% CIOr or BEAT EFO ID
ENSG00000138646rs10516809488499935?Pulmonary function decline22424883[0.17-0.44] unit increase0.3063EFO_0004314
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000138646's network

* RBP PPI network refers to all genes directly bind to RBP
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0000079regulation of cyclin-dependent protein serine/threonine kinase activity10581175.TASProcess
GO:0000209protein polyubiquitination-TASProcess
GO:0003723RNA binding22658674.HDAFunction
GO:0004842ubiquitin-protein transferase activity-TASFunction
GO:0005515protein binding20133869.20308324.IPIFunction
GO:0005829cytosol-TASComponent
GO:0032020ISG15-protein conjugation21873635.IBAProcess
GO:0032020ISG15-protein conjugation20308324.IDAProcess
GO:0032480negative regulation of type I interferon production-TASProcess
GO:0042296ISG15 transferase activity21873635.IBAFunction
GO:0042296ISG15 transferase activity20308324.IDAFunction
GO:0045087innate immune response-IEAProcess
GO:0048471perinuclear region of cytoplasm-IEAComponent
GO:0050688regulation of defense response to virus21873635.IBAProcess
GO:0050688regulation of defense response to virus20308324.IDAProcess
GO:0051607defense response to virus-IEAProcess
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