EuRBPDB

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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
26554377Down-Regulation of Nucleolar and Spindle-Associated Protein 1 (NUSAP1) Expression Suppresses Tumor and Cell Proliferation and Enhances Anti-Tumor Effect of Paclitaxel in Oral Squamous Cell Carcinoma.PLoS One2015 Nov 10Okamoto Adoi: 10.1371/journal.pone.0142252
20053754Antibodies specifically target AML antigen NuSAP1 after allogeneic bone marrow transplantation.Blood2010 Mar 11Wadia PPdoi: 10.1182/blood-2009-03-211375
29853313High NUSAP1 expression predicts poor prognosis in colon cancer.Pathol Res Pract2018 JulLiu Zdoi: 10.1016/j.prp.2018.05.017
30678687Nucleolar and spindle associated protein 1 promotes metastasis of cervical carcinoma cells by activating Wnt/β-catenin signaling.J Exp Clin Cancer Res2019 Jan 24Li Hdoi: 10.1186/s13046-019-1037-y.
22349817Increased expression of NuSAP in recurrent prostate cancer is mediated by E2F1.Oncogene2013 Jan 3Gulzar ZGdoi: 10.1038/onc.2012.27
26485712High Levels of Nucleolar Spindle-Associated Protein and Reduced Levels of BRCA1 Expression Predict Poor Prognosis in Triple-Negative Breast Cancer.PLoS One2015 Oct 20Chen Ldoi: 10.1371/journal.pone.0140572
23405241Mitosis is a source of potential markers for screening and survival and therapeutic targets in cervical cancer.PLoS One2013Espinosa AMdoi: 10.1371/journal.pone.0055975
29608915NUSAP1 gene silencing inhibits cell proliferation, migration and invasion through inhibiting DNMT1 gene expression in human colorectal cancer.Exp Cell Res2018 Jun 15Han Gdoi: 10.1016/j.yexcr.2018.03.039

Differential Expression

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
BLCAchr1541332976Missense_MutationNAE7Q0.23
BLCAchr1541349167Missense_MutationnovelE78Q0.24
BLCAchr1541375780Missense_MutationnovelD359H0.09
BLCAchr1541356089Missense_MutationNAD167Y0.23
BLCAchr1541365539SilentNAL266L0.18
BLCAchr1541365568Missense_MutationnovelS276C0.53
BLCAchr1541365448Missense_MutationNAR236T0.57
BLCAchr1541365435Missense_MutationnovelP232A0.3
BRCAchr1541332989Missense_MutationNAS11C0.26
BRCAchr15413802213'UTRnovel0.06
CESCchr1541375731Missense_MutationnovelL342F0.26
CESCchr1541332976Missense_Mutationrs745709236E7K0.13
CESCchr1541371561Missense_Mutationrs748216021R295C0.27
CESCchr1541351062SilentNAL127L0.24
CESCchr15413328655'FlankNA0.71
COADchr1541349172SilentnovelR79R0.09
COADchr15413328505'Flanknovel0.41
COADchr15413802443'UTRnovel0.31
COADchr1541365555Missense_MutationnovelR272C0.18
COADchr1541365520Missense_MutationNAS260T0.16
HNSCchr1541349169SilentnovelE78E0.15
HNSCchr1541351117Missense_MutationnovelA146T0.2
KIRPchr1541365528Missense_MutationNAT263A0.39
KIRPchr15413804473'Flanknovel0.42
KIRPchr1541377297Nonsense_MutationNAQ409*0.36
LGGchr1541375766Missense_MutationnovelK354R0.12
LIHCchr1541365400Splice_SitenovelX221_splice0.46
LIHCchr15413328295'Flanknovel0.26
LUADchr1541332963Missense_MutationnovelI2M0.15
LUADchr1541365579Missense_MutationnovelT280A0.82
LUADchr1541365469Missense_MutationNAS243Y0.52
LUADchr1541375776SilentnovelV357V0.29
LUSCchr1541375826Missense_MutationNAK374T0.13
LUSCchr1541358196Missense_MutationNAD200H0.19
LUSCchr1541371676Missense_MutationnovelS333F0.18
OVchr1541349183Missense_MutationNAG83D0.13
OVchr1541365560SilentnovelS273S0.31
PAADchr1541365503SilentnovelR254R0.18
READchr15413329065'UTRnovel0.42
READchr1541351029Missense_MutationnovelF116L0.44
SKCMchr1541351036Missense_MutationNAH119Y0.33
SKCMchr1541351065Missense_MutationNAR128S0.37
SKCMchr1541351062SilentNAL127L0.52
STADchr1541375745Missense_MutationNAT347M0.35
STADchr1541358214Missense_Mutationrs773154411K206E0.21
STADchr1541349221Missense_Mutationrs775051382R96C0.28
STADchr1541358249SilentNAN217N0.23
TGCTchr15413329095'UTRnovel0.32
THYMchr15413329205'UTRnovel0.32
UCECchr1541351011Missense_MutationNAI110M0.3
UCECchr15413329205'UTRnovel0.33
UCECchr1541380124Nonsense_MutationNAR422*0.33
UCECchr1541351130Splice_SitenovelX150_splice0.46
UCECchr15413801903'UTRnovel0.45
UCECchr1541375795SilentnovelL364L0.2
UCECchr1541365558Missense_MutationNAS273T0.24
UCECchr1541349147Missense_MutationNAI71N0.23
UCECchr1541380125Missense_Mutationrs370147837R422Q0.42
UCECchr1541365524Missense_MutationNAQ261H0.24
UCECchr1541380114Silentrs187207613R418R0.2
UCECchr1541365486Nonsense_Mutationrs202144126R249*0.26
UCECchr1541351093Missense_Mutationrs189325557D138H0.2
UCECchr1541356080Missense_MutationnovelL164I0.3
UCECchr1541371606Missense_Mutationrs574269860V310M0.38
UCECchr1541351081Missense_MutationnovelP134S0.13
UCECchr1541371566SilentnovelS296S0.24
UCECchr1541377245Missense_MutationNAQ391H0.23
UCECchr15413329155'UTRnovel0.46

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
ACCDEL0.23330.079424
CESCDEL0.20.00049652
COADDEL0.35482.3878e-07
GBMDEL0.21843.453e-12
HNSCDEL0.17240.11567
KICHAMP0.27270.21756
KIRPDEL0.10760.2062
LUADDEL0.39536.8561e-07
MESODEL0.31034.5411e-10
PAADDEL0.13040.13216
READDEL0.44240.025797
SARCDEL0.20230.18974
STADDEL0.1953.2335e-05
UCECDEL0.23937.1012e-08

Survival Analysis
CancerP-value Q-value
THYM0.0035

Kaplan-Meier Survival Analysis

KIRC0.0058

Kaplan-Meier Survival Analysis

STAD0.046

Kaplan-Meier Survival Analysis

SARC0.0056

Kaplan-Meier Survival Analysis

MESO0.0001

Kaplan-Meier Survival Analysis

ACC0.00028

Kaplan-Meier Survival Analysis

PRAD0.033

Kaplan-Meier Survival Analysis

LUSC0.036

Kaplan-Meier Survival Analysis

KIRP0.00021

Kaplan-Meier Survival Analysis

PAAD0.00019

Kaplan-Meier Survival Analysis

PCPG0.039

Kaplan-Meier Survival Analysis

CESC0.019

Kaplan-Meier Survival Analysis

KICH0.016

Kaplan-Meier Survival Analysis

LIHC0.0013

Kaplan-Meier Survival Analysis

LUAD0.00011

Kaplan-Meier Survival Analysis

UVM0.012

Kaplan-Meier Survival Analysis

Drugs

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Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBPome
  • Expression
  • Transcripts
  • Gene Model
  • Phenotypes
  • PPI
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000137804 (Gene tree)
Gene ID
51203
Gene Symbol
NUSAP1
Alias
FLJ13421|LNP|ANKT|NuSAP1|SAPL|BM037|PRO0310p1|Q0310
Full Name
nucleolar and spindle associated protein 1
Gene Type
protein_coding
Species
Homo_sapiens
Status
putative
Strand
Plus strand
Length
48,357 bases
Position
chr15:41,332,694-41,381,050
Accession
18538
RBP type
non-canonical RBP
Summary
NUSAP1 is a nucleolar-spindle-associated protein that plays a role in spindle microtubule organization (Raemaekers et al., 2003 [PubMed 12963707]).[supplied by OMIM, Jun 2009]
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & HEK2932018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
22658674Insights into RNA biology from an atlas of mammalian mRNA-binding proteinsRIC & Hela2012 May 31Castello ADOI: 10.1016/j.cell.2012.04.031
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & Hela2018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000559659NUSAP1-209529--- (aa)--
ENST00000558582NUSAP1-206546--- (aa)--
ENST00000559596NUSAP1-2081629XM_006720559ENSP00000453403441 (aa)XP_006720622Q9BXS6
ENST00000560177NUSAP1-2102232XM_006720560ENSP00000453657440 (aa)XP_006720623Q9BXS6
ENST00000560747NUSAP1-2122256-ENSP00000454097439 (aa)-Q9BXS6
ENST00000450592NUSAP1-2031301-ENSP00000401014378 (aa)-Q9BXS6
ENST00000414849NUSAP1-2022274XM_005254428ENSP00000400746440 (aa)XP_005254485Q9BXS6
ENST00000558123NUSAP1-2051934--- (aa)--
ENST00000557840NUSAP1-204416-ENSP0000045342868 (aa)-H0YM18
ENST00000260359NUSAP1-2012409XM_005254430ENSP00000260359426 (aa)XP_005254487Q9BXS6
ENST00000559046NUSAP1-207580-ENSP0000045272576 (aa)-H0YKA7
ENST00000560318NUSAP1-211485--- (aa)--
ENST00000560898NUSAP1-213708-ENSP00000453558144 (aa)-H0YMD2
Gene Model
Click here to download ENSG00000137804's gene model file
Phenotypes
ensgIDTraitpValuePubmed ID
ENSG00000137804Platelet Function Tests6.5400000E-006-
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000137804's network

* RBP PPI network refers to all genes directly bind to RBP
Orthologs identified by RBPome
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000137804NUSAP19460.798ENSMUSG00000027306Nusap19961.384Mus_musculus
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0000070mitotic sister chromatid segregation12963707.IDAProcess
GO:0000281mitotic cytokinesis21873635.IBAProcess
GO:0000281mitotic cytokinesis12963707.IDAProcess
GO:0003677DNA binding-IEAFunction
GO:0003723RNA binding22658674.HDAFunction
GO:0005515protein binding25416956.IPIFunction
GO:0005694chromosome-IEAComponent
GO:0005730nucleolus21873635.IBAComponent
GO:0005737cytoplasm-IEAComponent
GO:0005876spindle microtubule21873635.IBAComponent
GO:0007076mitotic chromosome condensation21873635.IBAProcess
GO:0007076mitotic chromosome condensation12963707.IDAProcess
GO:0008017microtubule binding21873635.IBAFunction
GO:0040001establishment of mitotic spindle localization21873635.IBAProcess
GO:0040001establishment of mitotic spindle localization12963707.IDAProcess
GO:0045840positive regulation of mitotic nuclear division12963707.IDAProcess
GO:0072686mitotic spindle21873635.IBAComponent
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