EuRBPDB

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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
16287074The leukocyte protein L-plastin induces proliferation, invasion and loss of E-cadherin expression in colon cancer cells.Int J Cancer2006 Apr 15Foran E-
10393844Suppression of prostate carcinoma cell invasion by expression of antisense L-plastin gene.Am J Pathol1999 JulZheng J-
12843666Preparation and characterization of recombinant murine p65/L-plastin expressed in Escherichia coli and high-titer antibodies against the protein.Biosci Biotechnol Biochem2003 JunShinomiya H-
11389068The use of the L-plastin promoter for adenoviral-mediated, tumor-specific gene expression in ovarian and bladder cancer cell lines.Cancer Res2001 Jun 1Peng XY-
22262972Plastin family of actin-bundling proteins: its functions in leukocytes, neurons, intestines, and cancer.Int J Cell Biol2012Shinomiya Hdoi: 10.1155/2012/213492
26413813GLI1 orchestrates CXCR4/CXCR7 signaling to enhance migration and metastasis of breast cancer cells.Oncotarget2015 Oct 20Inaguma Sdoi: 10.18632/oncotarget.5203.
28981098AP4 modulated by the PI3K/AKT pathway promotes prostate cancer proliferation and metastasis of prostate cancer via upregulating L-plastin.Cell Death Dis2017 Oct 5Chen Cdoi: 10.1038/cddis.2017.437.
10195877Use of L-plastin promoter to develop an adenoviral system that confers transgene expression in ovarian cancer cells but not in normal mesothelial cells.Cancer Gene Ther1999 Mar-AprChung I-
8055865Discovery and characterization of two novel human cancer-related proteins using two-dimensional gel electrophoresis.Electrophoresis1994 Mar-AprLeavitt J-
11735128Differential expression of the L-plastin gene in human colorectal cancer progression and metastasis.Biochem Biophys Res Commun2001 Dec 14Otsuka M-
10668786Upregulation of L-plastin gene by testosterone in breast and prostate cancer cells: identification of three cooperative androgen receptor-binding sequences.DNA Cell Biol2000 JanLin CS-
16281503[Identification of response element gene sequence for non-steroid hormone transcription factors for the activation and up-regulation of L-plastin expression in prostate cancer].Zhonghua Nan Ke Xue2005 OctLin TX-
15960882Plastins: versatile modulators of actin organization in (patho)physiological cellular processes.Acta Pharmacol Sin2005 JulDelanote V-
20169155Quantitative kinetic study of the actin-bundling protein L-plastin and of its impact on actin turn-over.PLoS One2010 Feb 15Al Tanoury Zdoi: 10.1371/journal.pone.0009210.
19799649The actin filament cross-linker L-plastin confers resistance to TNF-alpha in MCF-7 breast cancer cells in a phosphorylation-dependent manner.J Cell Mol Med2010 JunJanji Bdoi: 10.1111/j.1582-4934.2009.00918.x
18288642Analysis of the expression of biomarkers in urinary bladder cancer using a tissue microarray.Mol Carcinog2008 SepHarris LDdoi: 10.1002/mc.20420.
20878578[Significance of plasmic L-plastin levels in the diagnosis of colorectal cancer].Zhonghua Wei Chang Wai Ke Za Zhi2010 SepYuan CB-
23142595Different Ca2+-sensitivities between the EF-hands of T- and L-plastins.Biochem Biophys Res Commun2012 Dec 14Miyakawa Tdoi: 10.1016/j.bbrc.2012.10.126
25120647Matrigel induces L-plastin expression and promotes L-plastin-dependent invasion in human cholangiocarcinoma cells.Oncol Lett2014 SepChaijan S-
28230172Evidence for Critical Role of Lymphocyte Cytosolic Protein 1 in Oral Cancer.Sci Rep2017 Feb 23Koide Ndoi: 10.1038/srep43379.
24438191Metastasis of prostate cancer and melanoma cells in a preclinical in vivo mouse model is enhanced by L-plastin expression and phosphorylation.Mol Cancer2014 Jan 18Riplinger SMdoi: 10.1186/1476-4598-13-10.
28145401The Calcium-Dependent Switch Helix of L-Plastin Regulates Actin Bundling.Sci Rep2017 Feb 1Ishida Hdoi: 10.1038/srep40662.
24170770Plastin polymorphisms predict gender- and stage-specific colon cancer recurrence after adjuvant chemotherapy.Mol Cancer Ther2014 FebNing Ydoi: 10.1158/1535-7163.MCT-13-0646
23479363Composite three-marker assay for early detection of kidney cancer.Cancer Epidemiol Biomarkers Prev2013 MarSu Kim Ddoi: 10.1158/1055-9965.EPI-12-1156.
26945069Fascin Rigidity and L-plastin Flexibility Cooperate in Cancer Cell Invadopodia and Filopodia.J Biol Chem2016 Apr 22Van Audenhove Idoi: 10.1074/jbc.M115.706937
27460703Basement membrane protein ladinin-1 and the MIF-CD44-β1 integrin signaling axis are implicated in laryngeal cancer metastasis.Biochim Biophys Acta2016 OctKlobucar Mdoi: 10.1016/j.bbadis.2016.07.014
26631483L-plastin Ser5 phosphorylation in breast cancer cells and in vitro is mediated by RSK downstream of the ERK/MAPK pathway.FASEB J2016 MarLommel MJdoi: 10.1096/fj.15-276311
26148677An NKX3.1 binding site polymorphism in the l-plastin promoter leads to differential gene expression in human prostate cancer.Int J Cancer2016 Jan 1Chen Cdoi: 10.1002/ijc.29677
28499703miR-375 Regulates Invasion-Related Proteins Vimentin and L-Plastin.Am J Pathol2017 JulJimenez Ldoi: 10.1016/j.ajpath.2017.02.019
29293625Targeted deletion of the zebrafish actin-bundling protein L-plastin (lcp1).PLoS One2018 Jan 2Kell MJdoi: 10.1371/journal.pone.0190353
30583289Exosomal Release of L-Plastin by Breast Cancer Cells Facilitates Metastatic Bone Osteolysis.Transl Oncol2019 MarTiedemann Kdoi: 10.1016/j.tranon.2018.11.014
31302031Reduced exosomal L-Plastin is responsible for radiation-induced bystander effect.Exp Cell Res2019 Jul 11:111498Freudenmann LKdoi: 10.1016/j.yexcr.2019.111498
23082473The study of different chromosomal aberrations, CD38 and ZAP-70 in chronic lymphocytic leukemia patients.Egypt J Immunol2011Hassab AH-
3211125Molecular cloning and characterization of plastin, a human leukocyte protein expressed in transformed human fibroblasts.Mol Cell Biol1988 NovLin CS-
2378651Correction of the N-terminal sequences of the human plastin isoforms by using anchored polymerase chain reaction: identification of a potential calcium-binding domain.Mol Cell Biol1990 AprLin CS-
1966546Enhanced phosphorylation of 65 and 74 kDa proteins by tumor necrosis factor and interleukin-1 in human peripheral blood mononuclear cells.Cytokine1990 JanShiroo M-
8548753Characterization of the M(r) 65,000 lymphokine-activated killer proteins phosphorylated after tumor target binding: evidence that pp65a and pp65b are phosphorylated forms of L-plastin.Cancer Res1996 Jan 1Frederick MJ-
8428952Human plastin genes. Comparative gene structure, chromosome location, and differential expression in normal and neoplastic cells.J Biol Chem1993 Feb 5Lin CS-
8428953Characterization of the human L-plastin gene promoter in normal and neoplastic cells.J Biol Chem1993 Feb 5Lin CS-
7806577Functional differences between L- and T-plastin isoforms.J Cell Biol1994 DecArpin M-
12719708Cytotoxic effect of replication-competent adenoviral vectors carrying L-plastin promoter regulated E1A and cytosine deaminase genes in cancers of the breast, ovary and colon.Cancer Gene Ther2003 MayAkbulut H-
12231175Adenoviral vectors with E1A regulated by tumor-specific promoters are selectively cytolytic for breast cancer and melanoma.Mol Ther2002 SepZhang L-
11062740Expression patterns of L-plastin isoform in normal and carcinomatous breast tissues.Anticancer Res2000 Sep-OctLapillonne A-
16179927Engineering conditionally replication-competent adenoviral vectors carrying the cytosine deaminase gene increases the infectivity and therapeutic effect for breast cancer gene therapy.Cancer Gene Ther2006 AprLiu Y-
15752138Molecular basis for dissimilar nuclear trafficking of the actin-bundling protein isoforms T- and L-plastin.Traffic2005 AprDelanote V-
15570008Vector targeting makes 5-fluorouracil chemotherapy less toxic and more effective in animal models of epithelial neoplasms.Clin Cancer Res2004 Nov 15Akbulut H-
15283466Recombinant adenoviral vector containing tumor-specific L-plastin promoter fused to cytosine deaminase gene as a transcription unit: generation and functional test.Arch Pharm Res2004 JunChung I-
19821573Molecular proteomics imaging of tumor interfaces by mass spectrometry.J Proteome Res2010 Feb 5Kang Sdoi: 10.1021/pr900666q.
19726756An alpaca single-domain antibody blocks filopodia formation by obstructing L-plastin-mediated F-actin bundling.FASEB J2010 JanDelanote Vdoi: 10.1096/fj.09-134304
17679557Cytotoxic effect of a replication-incompetent adenoviral vector with cytosine deaminase gene driven by L-plastin promoter in hepatocellular carcinoma cells.Arch Pharm Res2007 JunJung K-
17335876Ectopic expression of L-plastin in human tumor cells: diagnostic and therapeutic implications.Adv Enzyme Regul2007Samstag Y-
17290393Phosphorylation of ectopically expressed L-plastin enhances invasiveness of human melanoma cells.Int J Cancer2007 Jun 15Klemke M-
21737656Identification of polymorphisms associated with hypertriglyceridemia and prolonged survival induced by bexarotene in treating non-small cell lung cancer.Anticancer Res2011 JunLuo W-
25191796Potential diagnostic significance of HSP90, ACS/TMS1, and L-plastin in the identification of melanoma.Melanoma Res2014 DecStrickler AGdoi: 10.1097/CMR.0000000000000115.

Differential Expression

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
BLCAchr1346134178Silentrs111548644V525V0.09
BLCAchr1346144513SilentnovelT394T0.16
BLCAchr1346148354Missense_Mutationrs759502564R326W0.45
BLCAchr1346154814SilentnovelF188F0.13
BLCAchr1346154852Missense_MutationnovelD176N0.46
BLCAchr1346146964Missense_MutationnovelR373T0.17
BLCAchr1346127712Missense_MutationNAS588C0.61
BRCAchr1346158644Missense_MutationNAH79R0.33
BRCAchr1346151067Missense_MutationnovelL251V0.31
BRCAchr1346127644Missense_MutationNAM611L0.15
BRCAchr1346127712Missense_MutationNAS588F0.32
BRCAchr1346130934Missense_MutationnovelP544L0.22
CESCchr1346142331Missense_Mutationrs755322384R488H0.39
CESCchr13461275773'UTRnovel0.11
CESCchr1346142837Intronrs7647629940.26
CESCchr13461259903'UTRnovel0.28
COADchr1346148434Missense_Mutationrs779555319Y299F0.09
COADchr1346148436SilentnovelA298A0.08
COADchr1346146994Missense_MutationnovelN363S0.12
COADchr1346142331Missense_Mutationrs755322384R488H0.42
COADchr1346158924Missense_MutationnovelP44S0.38
COADchr1346142331Missense_Mutationrs755322384R488H0.25
COADchr1346142331Missense_Mutationrs755322384R488H0.2
COADchr1346156449SilentNAG160G0.39
COADchr1346156499Missense_MutationnovelI144V0.05
COADchr1346130896Missense_Mutationrs534221736D557N0.12
COADchr1346158906Missense_MutationNAV50L0.2
COADchr1346127591Nonstop_Mutationnovel*628Cext*140.15
ESCAchr13461275903'UTRnovel0.24
ESCAchr1346134203Missense_Mutationrs768084208N517S0.1
ESCAchr1346144513SilentnovelT394T0.4
GBMchr1346144461Nonsense_MutationNAR412*0.32
GBMchr1346154880Frame_Shift_InsnovelM166Ifs*110.06
GBMchr1346147070Missense_MutationnovelL338M0.2
GBMchr1346151078Missense_MutationnovelA247D0.33
GBMchr1346154829Frame_Shift_InsnovelK184Efs*310.29
GBMchr1346158892SilentnovelT54T0.07
HNSCchr1346158616Missense_Mutationrs762754615K88N0.28
HNSCchr1346143377Missense_MutationnovelF427L0.06
HNSCchr1346152783Missense_MutationnovelE246K0.2
HNSCchr1346147021Missense_MutationNAD354V0.3
HNSCchr1346158940Missense_MutationnovelF38L0.26
HNSCchr1346156445Missense_MutationnovelV162F0.44
HNSCchr1346150937Missense_MutationnovelK294R0.35
HNSCchr1346142410Missense_MutationnovelY462D0.25
HNSCchr1346127617Missense_MutationnovelM620L0.63
HNSCchr1346127680Missense_MutationnovelA599P0.03
HNSCchr1346158573Missense_MutationnovelI103F0.22
HNSCchr1346142331Missense_Mutationrs755322384R488H0.14
HNSCchr1346147012Missense_Mutationrs759151052R357Q0.1
HNSCchr1346127703Missense_MutationnovelR591Q0.17
LGGchr1346147098In_Frame_DelnovelK328del0.32
LGGchr1346156569Missense_MutationnovelE120D0.08
LGGchr13461275323'UTRnovel0.41
LIHCchr13461273413'UTRnovel1
LIHCchr1346156513Missense_MutationnovelD139G0.12
LIHCchr1346156514Missense_MutationnovelD139Y0.12
LIHCchr13461275153'UTRnovel0.74
LUADchr1346152860Frame_Shift_DelnovelK220Sfs*290.26
LUADchr1346144486Missense_MutationnovelW403C0.1
LUADchr1346144472Missense_MutationnovelG408V0.24
LUADchr1346142326Missense_MutationnovelL490V0.35
LUADchr1346134251Splice_SitenovelX501_splice0.2
LUADchr1346144514Missense_Mutationrs745890489T394K0.24
LUADchr1346142373Missense_MutationNAS474F0.32
LUADchr1346147098Missense_MutationnovelK328N0.38
LUADchr1346142359Missense_MutationNAG479C0.49
LUADchr1346142404Missense_MutationNAV464L0.14
LUADchr1346152835SilentnovelL228L0.18
LUSCchr1346156568Nonsense_MutationNAE121*0.24
LUSCchr1346146923Missense_MutationnovelW387R0.23
LUSCchr1346151046Missense_MutationnovelL258M0.77
LUSCchr1346127705SilentnovelA590A0.22
LUSCchr1346150976Missense_MutationnovelA281E0.28
LUSCchr1346147012Missense_MutationnovelR357P0.52
LUSCchr1346151035SilentnovelL261L0.28
LUSCchr1346134214Silentrs749367534G513G0.29
LUSCchr1346150985Missense_MutationNAL278Q0.42
LUSCchr1346158569Missense_MutationnovelG104D0.09
LUSCchr13461275333'UTRnovel0.26
LUSCchr1346146942SilentnovelP380P0.35
LUSCchr1346156522Missense_MutationNAN136S0.21
LUSCchr1346152937SilentnovelL194L0.29
LUSCchr1346158963Missense_MutationNAF31I0.42
LUSCchr1346151003Missense_MutationNAR272T0.85
LUSCchr1346144492Missense_MutationnovelR401S0.43
LUSCchr1346156442Frame_Shift_DelnovelL163Ffs*40.18
OVchr1346127709Frame_Shift_InsnovelM589Tfs*180.03
OVchr1346127601Missense_MutationnovelK625M0.06
OVchr1346158541SilentNAG113G0.95
OVchr1346154820SilentnovelT186T0.27
OVchr1346146946Missense_MutationnovelK379I0.03
OVchr1346142381Silentrs141184605A471A0.1
OVchr13461275753'UTRnovel0.05
OVchr1346156464Missense_MutationnovelN155K0.05
PAADchr1346144460Missense_Mutationrs772323138R412Q0.04
PAADchr1346127703Missense_MutationnovelR591Q0.14
PAADchr1346130831SilentnovelE578E0.17
PAADchr1346142407Missense_Mutationrs541702713A463T0.2
PAADchr1346156480Missense_MutationNAT150M0.14
PAADchr1346159658Missense_MutationnovelA2V0.17
PRADchr1346159644Missense_MutationnovelS7P0.19
PRADchr1346127609SilentnovelK622K0.08
READchr1346134248Missense_MutationNAY502S0.14
READchr1346158848Missense_MutationnovelI69T0.22
READchr1346134228Nonsense_MutationNAE509*0.24
READchr1346146964Missense_MutationNAR373I0.16
READchr13461274973'UTRnovel0.4
READchr13461275863'UTRnovel0.06
SARCchr1346143308SilentnovelL450L0.24
SKCMchr1346151053SilentNAG255G0.46
SKCMchr1346144467Missense_MutationnovelN410D0.36
SKCMchr1346134235SilentNAI506I0.51
SKCMchr1346148438Missense_MutationnovelA298T0.26
SKCMchr1346147009Missense_MutationNAG358E0.47
SKCMchr1346152842Missense_MutationNAG226E0.44
SKCMchr1346142412Missense_MutationNAN461I0.11
SKCMchr13461274763'UTRnovel0.46
SKCMchr1346143306Missense_MutationNAG451E0.17
SKCMchr1346147014SilentNAV356V0.53
SKCMchr1346134127Splice_RegionNAK542K0.56
SKCMchr1346150981Missense_MutationnovelE279D0.49
SKCMchr1346159630Missense_MutationnovelM11I0.41
STADchr1346158545Missense_MutationNAV112G0.24
STADchr1346158902Missense_MutationNAR51Q0.32
STADchr1346146979Missense_MutationNAA368V0.04
STADchr1346144440Splice_SiteNAX418_splice0.78
STADchr1346151006Missense_MutationNAL271Q0.23
STADchr1346130915SilentnovelL550L0.05
STADchr1346156556Missense_MutationnovelA125T0.19
STADchr1346143369Missense_MutationNAY430C0.35
UCECchr1346156509SilentnovelC140C0.34
UCECchr1346127712Missense_MutationNAS588Y0.35
UCECchr1346134124Splice_Regionnovel0.13
UCECchr13461274813'UTRnovel0.45
UCECchr1346146987SilentnovelA365A0.09
UCECchr1346159684Splice_Regionnovel0.08
UCECchr1346156501Missense_MutationNAV143A0.33
UCECchr13461275663'UTRrs1824441400.12
UCECchr13461260563'UTRnovel0.5
UCECchr1346142375SilentnovelF473F0.48
UCECchr1346142737Intronnovel0.48
UCECchr1346142395Missense_MutationnovelG467W0.27
UCECchr1346147080SilentnovelA334A0.32
UCECchr1346152792Missense_MutationnovelS243G0.23
UCECchr1346154820SilentnovelT186T0.29
UCECchr1346154845Missense_MutationnovelR178I0.28
UCECchr1346142406Missense_Mutationrs772265981A463V0.08
UCECchr1346142821Intronnovel0.42
UCECchr13461260823'UTRnovel0.29
UCECchr13461264963'UTRnovel0.58
UCECchr1346142382Missense_Mutationrs368627380A471V0.43
UCECchr1346142860Intronnovel0.25
UCECchr1346144494Missense_MutationnovelR401G0.12
UCECchr1346127688Missense_MutationnovelR596I0.51
UCECchr1346134231Missense_MutationnovelE508K0.38
UCECchr1346142381Silentrs141184605A471A0.49
UCECchr13461259973'UTRnovel0.29
UCECchr13461275573'UTRnovel0.18
UCECchr1346152886SilentnovelI211I0.13
UCECchr13461260193'UTRnovel0.36
UCECchr1346130887In_Frame_InsnovelI559_Q560insIIAKIRN0.06
UCECchr1346130889Frame_Shift_InsnovelI559Sfs*90.01
UCECchr1346127703Missense_MutationnovelR591Q0.25
UCECchr1346146932Missense_MutationnovelD384Y0.44
UCECchr1346142320SilentnovelL492L0.35
UCECchr13461272633'UTRnovel0.4
UCECchr1346143391Missense_MutationNAA423T0.3
UCECchr1346158966Missense_MutationnovelS30G0.43
UCECchr1346156569Missense_MutationnovelE120D0.29
UCECchr1346142405Silentrs748447395A463A0.5
UCECchr1346144471SilentNAG408G0.44
UCECchr1346156472Missense_MutationnovelL153I0.33
UCECchr1346152821Missense_MutationnovelK233T0.14
UCECchr1346158633Missense_MutationnovelS83G0.3
UCECchr1346158881Missense_MutationnovelM58T0.37
UCECchr13461273923'UTRnovel0.41
UCECchr1346134234Missense_MutationNAL507I0.14
UCECchr1346130840Silentrs150402001N575N0.21
UCECchr1346142776Intronnovel0.31
UCECchr13461265623'UTRnovel0.25
UCECchr13461274133'UTRnovel0.13
UCSchr1346158869Missense_MutationnovelD62V0.54

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
BLCADEL0.29414.5185e-08
CESCDEL0.3392.1677e-19
COADDEL0.02880.24773
DLBCDEL0.10420.15679
ESCADEL0.32070.060925
HNSCDEL0.35631.2142e-15
KIRCDEL0.11740.031318
MESODEL0.41380.0010209
PAADDEL0.0870.050455
PRADDEL0.40041.1439e-73
READDEL0.03640.20625
UCSDEL0.44640.0031922

Survival Analysis
CancerP-value Q-value
THYM0.0054

Kaplan-Meier Survival Analysis

SARC0.0076

Kaplan-Meier Survival Analysis

ACC0.025

Kaplan-Meier Survival Analysis

SKCM0.0001

Kaplan-Meier Survival Analysis

BRCA0.03

Kaplan-Meier Survival Analysis

CESC0.0073

Kaplan-Meier Survival Analysis

LAML0.0058

Kaplan-Meier Survival Analysis

LGG0.0001

Kaplan-Meier Survival Analysis

LUAD0.00073

Kaplan-Meier Survival Analysis

UVM0.0001

Kaplan-Meier Survival Analysis

Drugs

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Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBPome
  • Expression
  • Transcripts
  • Gene Model
  • Phenotypes
  • PPI
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000136167 (Gene tree)
Gene ID
3936
Gene Symbol
LCP1
Alias
LPL|CP64|PLS2
Full Name
Lymphocyte Cytosolic Protein 1
Gene Type
protein_coding
Species
Homo_sapiens
Status
putative
Strand
Minus strand
Length
85,952 bases
Position
chr13:46,125,920-46,211,871
Accession
6528
RBP type
non-canonical RBP
Summary
Plastins are a family of actin-binding proteins that are conserved throughout eukaryote evolution and expressed in most tissues of higher eukaryotes. In humans, two ubiquitous plastin isoforms (L and T) have been identified. Plastin 1 (otherwise known as Fimbrin) is a third distinct plastin isoform which is specifically expressed at high levels in the small intestine. The L isoform is expressed only in hemopoietic cell lineages, while the T isoform has been found in all other normal cells of solid tissues that have replicative potential (fibroblasts, endothelial cells, epithelial cells, melanocytes, etc.). However, L-plastin has been found in many types of malignant human cells of non-hemopoietic origin suggesting that its expression is induced accompanying tumorigenesis in solid tissues. [provided by RefSeq, Jul 2008]
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
30352994Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome captureRIC & Jurkat2018 Oct 23Perez-Perri JIDOI:10.1038/s41467-018-06557-8
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000460190LCP1-205765--- (aa)--
ENST00000416500LCP1-203819-ENSP00000408052246 (aa)-Q5TBN3
ENST00000442275LCP1-204753-ENSP0000040215766 (aa)-Q5TBN5
ENST00000469227LCP1-206730--- (aa)--
ENST00000323076LCP1-2013787XM_005266374ENSP00000315757627 (aa)XP_005266431P13796
ENST00000494531LCP1-207537--- (aa)--
ENST00000398576LCP1-2023944-ENSP00000381581627 (aa)-P13796
Gene Model
Click here to download ENSG00000136167's gene model file
Phenotypes
ensgIDTraitpValuePubmed ID
ENSG00000136167Platelet Function Tests1.9063100E-005-
ENSG00000136167Non-alcoholic Fatty Liver Disease3E-623213074
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000136167's network

* RBP PPI network refers to all genes directly bind to RBP
Orthologs identified by RBPome
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000136167LCP110079.904ENSG00000102024PLS39979.904Homo_sapiens
ENSG00000136167LCP110098.485ENSMUSG00000021998Lcp110097.368Mus_musculus
ENSG00000136167LCP19837.984YDR129CSAC69838.426Saccharomyces_cerevisiae
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0001725stress fiber16636079.IMPComponent
GO:0001726ruffle16636079.IMPComponent
GO:0001726ruffle-ISSComponent
GO:0001891phagocytic cup-ISSComponent
GO:0002102podosome24236012.IDAComponent
GO:0002286T cell activation involved in immune response17294403.IDAProcess
GO:0003779actin binding2252891.NASFunction
GO:0005178integrin binding20183869.IPIFunction
GO:0005509calcium ion binding2378651.NASFunction
GO:0005615extracellular space16502470.22664934.HDAComponent
GO:0005737cytoplasm21873635.IBAComponent
GO:0005737cytoplasm16636079.IDAComponent
GO:0005737cytoplasm2378651.NASComponent
GO:0005829cytosol2111166.17294403.IDAComponent
GO:0005884actin filament21873635.IBAComponent
GO:0005884actin filament16636079.IMPComponent
GO:0005884actin filament-ISSComponent
GO:0005886plasma membrane-IDAComponent
GO:0005925focal adhesion16636079.IMPComponent
GO:0010737protein kinase A signaling16636079.IMPProcess
GO:0015629actin cytoskeleton-IDAComponent
GO:0016477cell migration16636079.IMPProcess
GO:0022617extracellular matrix disassembly24236012.IMPProcess
GO:0030054cell junction-TASComponent
GO:0030175filopodium16636079.IMPComponent
GO:0031100animal organ regeneration-IEAProcess
GO:0032432actin filament bundle21873635.IBAComponent
GO:0032432actin filament bundle16636079.IMPComponent
GO:0032587ruffle membrane-IEAComponent
GO:0033157regulation of intracellular protein transport17294403.IDAProcess
GO:0035722interleukin-12-mediated signaling pathway-TASProcess
GO:0042802identical protein binding-IEAFunction
GO:0044319wound healing, spreading of cells16636079.IMPProcess
GO:0048471perinuclear region of cytoplasm20183869.IDAComponent
GO:0051015actin filament binding21873635.IBAFunction
GO:0051015actin filament binding16636079.IMPFunction
GO:0051015actin filament binding-ISSFunction
GO:0051017actin filament bundle assembly21873635.IBAProcess
GO:0051017actin filament bundle assembly16636079.IMPProcess
GO:0051017actin filament bundle assembly-ISSProcess
GO:0051020GTPase binding24337748.IPIFunction
GO:0051639actin filament network formation21873635.IBAProcess
GO:0070062extracellular exosome19056867.20458337.23533145.HDAComponent
GO:0071803positive regulation of podosome assembly24236012.IMPProcess
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