EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
20574165	Frequent hyperphosphorylation of AS160 in breast cancer.	Cancer Biol Ther	2010 Aug 15	Jiang XH	-

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
ACC	chr13	75341142	Missense_Mutation	rs774714689	I532V	0.27
BLCA	chr13	75481529	Missense_Mutation	novel	R80Q	0.21
BLCA	chr13	75359852	Nonsense_Mutation	rs587777260	R363*	0.21
BLCA	chr13	75326391	Silent	NA	T613T	0.11
BLCA	chr13	75362158	Silent	NA	C316C	0.11
BLCA	chr13	75306463	Missense_Mutation	novel	D868H	0.33
BLCA	chr13	75324257	Silent	novel	P726P	0.21
BLCA	chr13	75306375	Frame_Shift_Del	novel	*L897Cfs2**	0.17
BLCA	chr13	75294980	Missense_Mutation	novel	D1064H	0.4
BLCA	chr13	75306363	Missense_Mutation	novel	R901K	0.33
BLCA	chr13	75310058	Frame_Shift_Del	novel	*D826Afs14**	0.06
BLCA	chr13	75326321	Nonsense_Mutation	rs771771231	R637*	0.59
BLCA	chr13	75481281	Missense_Mutation	novel	D163Y	0.57
BLCA	chr13	75294994	Missense_Mutation	NA	S1059C	0.16
BLCA	chr13	75286975	Silent	novel	L1238L	0.73
BLCA	chr13	75481381	Silent	novel	F129F	0.73
BLCA	chr13	75286929	Missense_Mutation	NA	E1254Q	0.08
BLCA	chr13	75299428	Silent	novel	L1020L	0.38
BLCA	chr13	75326345	Missense_Mutation	novel	E629Q	0.35
BLCA	chr13	75359771	Missense_Mutation	novel	Q390E	0.45
BLCA	chr13	75481537	Silent	novel	P77P	0.25
BRCA	chr13	75349208	Missense_Mutation	NA	P457R	0.3
BRCA	chr13	75292248	Missense_Mutation	NA	E1114K	0.43
BRCA	chr13	75288963	Nonsense_Mutation	novel	Q1212*	0.18
BRCA	chr13	75302343	Silent	novel	L937L	0.08
BRCA	chr13	75302343	Silent	NA	L937L	0.23
BRCA	chr13	75306446	Missense_Mutation	NA	R873S	0.72
BRCA	chr13	75481560	Missense_Mutation	NA	E70K	0.83
BRCA	chr13	75362218	Silent	rs765255505	F296F	0.19
BRCA	chr13	75362298	Nonsense_Mutation	NA	E270*	0.32
BRCA	chr13	75481430	Missense_Mutation	rs375426745	N113S	0.5
BRCA	chr13	75289008	Missense_Mutation	novel	E1197K	0.05
BRCA	chr13	75362324	Missense_Mutation	NA	G261E	0.18
BRCA	chr13	75326404	Missense_Mutation	NA	S609F	0.17
BRCA	chr13	75341129	Frame_Shift_Del	novel	*T528Ifs24**	0.18
BRCA	chr13	75306433	Missense_Mutation	NA	D878H	0.36
BRCA	chr13	75362124	Missense_Mutation	rs370555579	E328K	0.33
BRCA	chr13	75310065	Missense_Mutation	NA	E824K	0.25
BRCA	chr13	75294923	Missense_Mutation	novel	Y1083N	0.19
BRCA	chr13	75359786	Missense_Mutation	NA	I385F	0.19
BRCA	chr13	75356219	Silent	novel	I401I	0.13
CESC	chr13	75294887	Missense_Mutation	NA	Q1095E	0.06
CESC	chr13	75312882	Missense_Mutation	novel	K747E	0.18
CESC	chr13	75292183	Silent	rs540075377	E1135E	0.28
CESC	chr13	75302286	Silent	novel	L956L	0.14
CESC	chr13	75286355	3'UTR	novel		0.47
CESC	chr13	75349170	Missense_Mutation	novel	G470C	0.09
CESC	chr13	75349267	Silent	novel	F437F	0.11
CESC	chr13	75349251	Silent	rs778495732	L443L	0.16
COAD	chr13	75292180	Missense_Mutation	NA	S1136R	0.35
COAD	chr13	75481457	Missense_Mutation	novel	G104D	0.49
COAD	chr13	75312804	Missense_Mutation	novel	R773W	0.33
COAD	chr13	75326373	Silent	rs143268388	P619P	0.24
COAD	chr13	75337035	Missense_Mutation	novel	I539M	0.28
COAD	chr13	75312882	Missense_Mutation	novel	K747E	0.23
COAD	chr13	75481360	Silent	novel	L136L	0.38
COAD	chr13	75481749	Missense_Mutation	novel	I7F	0.35
COAD	chr13	75362024	Splice_Site	novel	X360_splice	0.17
COAD	chr13	75310112	Missense_Mutation	NA	L808P	0.33
COAD	chr13	75299476	Nonsense_Mutation	novel	E1004*	0.22
COAD	chr13	75362365	Silent	novel	D247D	0.07
COAD	chr13	75349243	Silent	novel	S445S	0.38
COAD	chr13	75299519	Silent	NA	L989L	0.31
COAD	chr13	75310067	Missense_Mutation	NA	G823E	0.27
COAD	chr13	75481653	Missense_Mutation	NA	W39R	0.45
COAD	chr13	75362098	Silent	NA	R336R	0.37
COAD	chr13	75362400	Missense_Mutation	NA	R236C	0.28
COAD	chr13	75362082	Missense_Mutation	rs760407055	A342T	0.44
COAD	chr13	75286816	Missense_Mutation	novel	K1291N	0.22
COAD	chr13	75309972	Nonsense_Mutation	NA	R855*	0.16
COAD	chr13	75324403	Splice_Site	NA	X678_splice	0.26
COAD	chr13	75326337	Silent	rs188607347	S631S	0.36
COAD	chr13	75289012	Silent	rs373137539	D1195D	0.35
COAD	chr13	75292267	Silent	novel	I1107I	0.12
COAD	chr13	75292269	Frame_Shift_Ins	novel	*I1107Gfs2**	0.12
COAD	chr13	75341186	Frame_Shift_Ins	novel	*H517Pfs9**	0.07
COAD	chr13	75481292	Frame_Shift_Del	novel	*F159Sfs16**	0.14
COAD	chr13	75326237	Missense_Mutation	rs376333903	R665C	0.25
COAD	chr13	75286740	3'UTR	novel		0.09
COAD	chr13	75294919	Missense_Mutation	NA	A1084D	0.22
COAD	chr13	75362452	Frame_Shift_Del	NA	*S219Qfs19**	0.23
ESCA	chr13	75286723	3'UTR	novel		0.13
ESCA	chr13	75349208	Missense_Mutation	NA	P457R	0.31
ESCA	chr13	75481639	Frame_Shift_Del	novel	*S44Rfs39**	0.46
GBM	chr13	75312828	Missense_Mutation	novel	V765F	0.03
GBM	chr13	75306327	Missense_Mutation	novel	T913N	0.08
GBM	chr13	75481705	Silent	novel	G21G	0.3
GBM	chr13	75286725	3'UTR	novel		0.56
GBM	chr13	75286973	Missense_Mutation	rs375003443	T1239M	0.2
GBM	chr13	75362581	Frame_Shift_Ins	novel	*Q176Afs4**	0.24
GBM	chr13	75341200	Silent	novel	E512E	0.45
GBM	chr13	75359768	Splice_Site	NA	X390_splice	0.29
HNSC	chr13	75362566	Silent	rs373080119	A180A	0.31
HNSC	chr13	75288988	Missense_Mutation	novel	E1203D	0.22
HNSC	chr13	75356211	Frame_Shift_Ins	novel	*E404Gfs8**	0.23
HNSC	chr13	75356184	Missense_Mutation	novel	Y413F	0.22
HNSC	chr13	75349208	Missense_Mutation	NA	P457R	0.27
HNSC	chr13	75299457	Missense_Mutation	novel	G1010V	0.41
HNSC	chr13	75356217	Missense_Mutation	novel	C402F	0.31
HNSC	chr13	75299463	Missense_Mutation	novel	C1008S	0.05
HNSC	chr13	75324324	Missense_Mutation	novel	S704F	0.44
HNSC	chr13	75324244	Missense_Mutation	novel	E731K	0.26
HNSC	chr13	75336983	Missense_Mutation	novel	D557N	0.16
HNSC	chr13	75324278	Silent	novel	Q719Q	0.24
KIRP	chr13	75310063	Silent	rs762449836	E824E	0.47
KIRP	chr13	75324347	Silent	novel	L696L	0.19
KIRP	chr13	75349279	Silent	NA	L433L	0.48
KIRP	chr13	75294936	Silent	novel	I1078I	0.29
LAML	chr13	75312817	Silent	novel	R768R	0.75
LGG	chr13	75481764	Missense_Mutation	NA	E2K	0.5
LGG	chr13	75299337	Missense_Mutation	rs767493446	S1050L	0.36
LGG	chr13	75312893	Missense_Mutation	novel	G743E	0.21
LGG	chr13	75310088	Missense_Mutation	rs766624952	P816L	0.4
LIHC	chr13	75481467	Missense_Mutation	NA	A101T	0.52
LIHC	chr13	75481736	Missense_Mutation	novel	P11R	0.84
LIHC	chr13	75310061	Missense_Mutation	rs531614085	D825V	0.53
LUAD	chr13	75310143	Missense_Mutation	novel	D798Y	0.56
LUAD	chr13	75286980	Missense_Mutation	novel	L1237F	0.14
LUAD	chr13	75324300	Missense_Mutation	novel	S712C	0.09
LUAD	chr13	75288954	Missense_Mutation	NA	D1215Y	0.3
LUAD	chr13	75310018	Silent	NA	L839L	0.26
LUAD	chr13	75362491	Silent	NA	L205L	0.11
LUAD	chr13	75310114	Silent	rs201049082	P807P	0.2
LUAD	chr13	75362086	Silent	NA	A340A	0.2
LUAD	chr13	75288949	Silent	novel	L1216L	0.06
LUAD	chr13	75362258	Missense_Mutation	NA	G283A	0.59
LUAD	chr13	75349188	Missense_Mutation	novel	L464I	0.08
LUAD	chr13	75286909	Missense_Mutation	NA	K1260N	0.23
LUSC	chr13	75312877	Missense_Mutation	novel	R748S	0.32
LUSC	chr13	75309988	Silent	novel	Q849Q	0.39
LUSC	chr13	75349221	Missense_Mutation	NA	C453S	0.13
LUSC	chr13	75362242	Silent	novel	A288A	0.28
LUSC	chr13	75302338	Missense_Mutation	novel	H939P	0.88
LUSC	chr13	75481423	Silent	NA	A115A	0.83
LUSC	chr13	75481406	Missense_Mutation	NA	H121R	0.63
LUSC	chr13	75341569	Missense_Mutation	NA	A476D	0.34
LUSC	chr13	75302259	Silent	rs367622658	A965A	0.25
LUSC	chr13	75312759	Missense_Mutation	NA	P788S	0.39
LUSC	chr13	75362113	Missense_Mutation	novel	Q331H	0.49
LUSC	chr13	75349252	Silent	novel	A442A	0.1
LUSC	chr13	75324322	Missense_Mutation	rs746805947	A705T	0.33
LUSC	chr13	75326262	Silent	novel	L656L	0.42
LUSC	chr13	75320022	Silent	novel	S738S	0.5
LUSC	chr13	75341122	Splice_Region	novel		0.16
LUSC	chr13	75294894	Silent	novel	F1092F	0.29
LUSC	chr13	75341583	Silent	NA	L471L	0.12
LUSC	chr13	75324382	Missense_Mutation	rs775000830	R685C	0.12
OV	chr13	75310095	Missense_Mutation	NA	E814Q	0.3
OV	chr13	75312762	Missense_Mutation	NA	S787A	0.11
OV	chr13	75294913	Missense_Mutation	NA	P1086L	0.47
OV	chr13	75294981	Silent	NA	H1063H	0.57
OV	chr13	75299506	Missense_Mutation	NA	L994V	0.31
OV	chr13	75310016	Missense_Mutation	novel	R840K	0.09
OV	chr13	75320034	Silent	novel	Q734Q	0.09
OV	chr13	75326207	Nonsense_Mutation	novel	E675*	0.08
PAAD	chr13	75302301	Silent	novel	S951S	0.15
PRAD	chr13	75481545	Missense_Mutation	novel	G75R	1
PRAD	chr13	75341139	Missense_Mutation	rs377319895	G533R	0.28
PRAD	chr13	75349208	Missense_Mutation	NA	P457R	0.07
READ	chr13	75362034	Missense_Mutation	NA	L358V	0.16
READ	chr13	75326382	Silent	rs778659370	A616A	0.26
READ	chr13	75286650	3'UTR	novel		0.23
READ	chr13	75286776	3'UTR	novel		0.05
READ	chr13	75286972	Silent	NA	T1239T	0.11
READ	chr13	75359799	Missense_Mutation	rs751078491	K380N	0.42
READ	chr13	75362210	Missense_Mutation	rs755204418	R299Q	0.06
READ	chr13	75310048	Missense_Mutation	novel	K829N	0.11
READ	chr13	75362059	Silent	NA	S349S	0.27
SARC	chr13	75286973	Missense_Mutation	rs375003443	T1239M	0.13
SARC	chr13	75356215	Missense_Mutation	rs377252828	R403W	0.28
SKCM	chr13	75292140	Missense_Mutation	novel	D1150N	0.74
SKCM	chr13	75324357	Missense_Mutation	NA	S693F	0.17
SKCM	chr13	75362163	Missense_Mutation	novel	R315W	0.67
SKCM	chr13	75324311	Silent	novel	F708F	0.44
SKCM	chr13	75288949	Silent	NA	L1216L	0.45
SKCM	chr13	75299384	Silent	novel	L1034L	0.5
SKCM	chr13	75294913	Missense_Mutation	NA	P1086L	0.16
SKCM	chr13	75324304	Missense_Mutation	NA	P711S	0.24
SKCM	chr13	75326331	Silent	novel	S633S	0.25
SKCM	chr13	75326332	Missense_Mutation	novel	S633F	0.25
SKCM	chr13	75481687	Silent	NA	G27G	0.23
SKCM	chr13	75286894	Silent	NA	L1265L	0.52
SKCM	chr13	75286989	Silent	NA	L1234L	0.19
SKCM	chr13	75289014	Missense_Mutation	NA	D1195N	0.45
SKCM	chr13	75356234	Missense_Mutation	NA	D396E	0.35
SKCM	chr13	75288938	Nonsense_Mutation	novel	L1220*	0.55
SKCM	chr13	75288939	Missense_Mutation	NA	L1220I	0.55
SKCM	chr13	75299507	Silent	novel	N993N	0.5
SKCM	chr13	75299510	Frame_Shift_Del	novel	*F992Lfs4**	0.5
SKCM	chr13	75362321	Missense_Mutation	rs751499017	S262F	0.52
SKCM	chr13	75362419	Silent	novel	F229F	0.32
SKCM	chr13	75287007	Nonsense_Mutation	novel	Q1228*	0.14
SKCM	chr13	75286754	3'UTR	novel		0.22
SKCM	chr13	75326254	Missense_Mutation	NA	G659E	0.14
SKCM	chr13	75286880	Missense_Mutation	rs749850246	P1270L	0.3
STAD	chr13	75289055	Missense_Mutation	NA	V1181A	0.35
STAD	chr13	75362524	Missense_Mutation	NA	D194E	0.05
STAD	chr13	75310060	Silent	novel	D825D	0.16
STAD	chr13	75481685	Missense_Mutation	novel	P28H	0.29
STAD	chr13	75312827	Missense_Mutation	NA	V765A	0.24
STAD	chr13	75310112	Frame_Shift_Del	novel	*L808Pfs32**	0.4
STAD	chr13	75326328	Silent	rs184072266	P634P	0.3
STAD	chr13	75299569	Missense_Mutation	NA	T973S	0.35
STAD	chr13	75327785	Silent	NA	S591S	0.32
STAD	chr13	75337007	Missense_Mutation	novel	T549S	0.27
STAD	chr13	75481457	Frame_Shift_Del	rs771111051	*G104Afs39**	0.2
STAD	chr13	75481406	Missense_Mutation	NA	H121R	0.09
STAD	chr13	75481617	Missense_Mutation	rs370400049	T51A	0.3
STAD	chr13	75481300	Silent	novel	C156C	0.53
STAD	chr13	75287017	Silent	NA	H1224H	0.07
STAD	chr13	75294912	Frame_Shift_Del	novel	*W1087Gfs12**	0.32
STAD	chr13	75481587	Missense_Mutation	novel	E61K	0.34
STAD	chr13	75341537	Missense_Mutation	novel	L487V	0.21
STAD	chr13	75481756	Silent	NA	P4P	0.33
STAD	chr13	75292118	Missense_Mutation	novel	E1157G	0.32
STAD	chr13	75324393	Missense_Mutation	rs372617227	S681L	0.28
STAD	chr13	75362125	Silent	rs773880965	H327H	0.43
STAD	chr13	75362124	Missense_Mutation	rs370555579	E328K	0.42
STAD	chr13	75327778	Missense_Mutation	rs201208079	R594W	0.28
STAD	chr13	75324258	Frame_Shift_Del	novel	*P726Hfs33**	0.42
STAD	chr13	75292129	Silent	rs368284408	T1153T	0.09
STAD	chr13	75299536	Missense_Mutation	NA	L984F	0.17
STAD	chr13	75481675	Silent	NA	P31P	0.38
STAD	chr13	75362317	Frame_Shift_Del	NA	*G264Efs26**	0.39
THCA	chr13	75356215	Silent	rs377252828	R403R	0.09
THCA	chr13	75294973	In_Frame_Ins	novel	H1066delinsPFNY	0.05
THCA	chr13	75294975	Nonsense_Mutation	novel	Y1065*	0.04
UCEC	chr13	75356160	Missense_Mutation	NA	A421V	0.43
UCEC	chr13	75306316	Nonsense_Mutation	rs745653179	E917*	0.38
UCEC	chr13	75356153	Missense_Mutation	NA	E423D	0.29
UCEC	chr13	75362259	Missense_Mutation	NA	G283W	0.35
UCEC	chr13	75286875	Missense_Mutation	NA	D1272N	0.28
UCEC	chr13	75312742	Silent	NA	Q793Q	0.22
UCEC	chr13	75292162	Silent	novel	E1142E	0.2
UCEC	chr13	75299364	Missense_Mutation	rs199560195	R1041H	0.34
UCEC	chr13	75286938	Missense_Mutation	novel	L1251M	0.05
UCEC	chr13	75302259	Silent	rs367622658	A965A	0.39
UCEC	chr13	75362199	Missense_Mutation	NA	D303Y	0.41
UCEC	chr13	75481527	Nonsense_Mutation	rs770167590	E81*	0.37
UCEC	chr13	75310015	Silent	novel	R840R	0.46
UCEC	chr13	75326389	Missense_Mutation	rs780599874	P614L	0.54
UCEC	chr13	75341198	Missense_Mutation	novel	L513R	0.53
UCEC	chr13	75309972	Nonsense_Mutation	NA	R855*	0.41
UCEC	chr13	75326373	Silent	NA	P619P	0.44
UCEC	chr13	75362440	Silent	NA	I222I	0.46
UCEC	chr13	75481370	Missense_Mutation	novel	S133I	0.35
UCEC	chr13	75326348	Missense_Mutation	NA	E628K	0.38
UCEC	chr13	75286944	Missense_Mutation	rs201344804	R1249W	0.34
UCEC	chr13	75326365	Missense_Mutation	novel	A622V	0.53
UCEC	chr13	75285788	3'UTR	novel		0.32
UCEC	chr13	75309971	Missense_Mutation	novel	R855Q	0.24
UCEC	chr13	75326373	Silent	rs143268388	P619P	0.16
UCEC	chr13	75302316	Missense_Mutation	NA	Q946H	0.27
UCEC	chr13	75312886	Silent	novel	G745G	0.12
UCEC	chr13	75312887	Missense_Mutation	novel	G745E	0.08
UCEC	chr13	75320030	Missense_Mutation	rs542340330	T736A	0.29
UCEC	chr13	75349186	Silent	NA	L464L	0.21
UCEC	chr13	75356236	Missense_Mutation	NA	D396N	0.12
UCEC	chr13	75362034	Missense_Mutation	novel	L358F	0.1
UCEC	chr13	75341213	Missense_Mutation	NA	Q508R	0.44
UCEC	chr13	75362101	Silent	rs145011623	P335P	0.39
UCEC	chr13	75359799	Missense_Mutation	rs751078491	K380N	0.42
UCEC	chr13	75285476	3'UTR	novel		0.7
UCEC	chr13	75336922	Missense_Mutation	novel	R577K	0.33
UCEC	chr13	75286952	Missense_Mutation	novel	S1246Y	0.39
UCEC	chr13	75310093	Missense_Mutation	novel	E814D	0.43
UCEC	chr13	75326321	Nonsense_Mutation	rs771771231	R637*	0.42
UCEC	chr13	75359799	Missense_Mutation	rs751078491	K380N	0.1
UCEC	chr13	75286877	Frame_Shift_Del	novel	*L1269Rfs4**	0.18
UCEC	chr13	75299531	Silent	rs557817497	G985G	0.31
UCEC	chr13	75326201	Missense_Mutation	novel	C677R	0.18
UCEC	chr13	75362473	Silent	novel	T211T	0.29
UCEC	chr13	75481464	Missense_Mutation	novel	S102P	0.22
UCEC	chr13	75286048	3'UTR	novel		0.44
UCEC	chr13	75288938	Missense_Mutation	novel	L1220S	0.27
UCEC	chr13	75362440	Silent	NA	I222I	0.24
UCEC	chr13	75294867	Silent	novel	V1101V	0.35
UCEC	chr13	75302330	Missense_Mutation	novel	P942S	0.22
UCEC	chr13	75359799	Missense_Mutation	rs751078491	K380N	0.36
UCEC	chr13	75286701	3'UTR	novel		0.31
UCEC	chr13	75288996	Missense_Mutation	novel	K1201E	0.14
UCEC	chr13	75312878	Missense_Mutation	novel	R748M	0.22
UCEC	chr13	75286311	3'UTR	novel		0.22
UCEC	chr13	75362549	Missense_Mutation	novel	A186D	0.33
UCEC	chr13	75310041	Nonsense_Mutation	novel	E832*	0.7
UCEC	chr13	75341511	Silent	novel	I495I	0.28
UCEC	chr13	75286725	3'UTR	novel		0.13
UCEC	chr13	75292187	Missense_Mutation	novel	C1134Y	0.21
UCEC	chr13	75299372	Silent	NA	L1038L	0.35
UCEC	chr13	75299490	Missense_Mutation	NA	S999F	0.47
UCEC	chr13	75362483	Missense_Mutation	NA	G208E	0.36
UCEC	chr13	75299337	Missense_Mutation	rs767493446	S1050L	0.19
UCEC	chr13	75302259	Silent	rs367622658	A965A	0.41
UCEC	chr13	75310016	Missense_Mutation	novel	R840K	0.12
UCEC	chr13	75324326	Missense_Mutation	novel	F703L	0.14
UCEC	chr13	75362401	Silent	novel	Q235Q	0.15
UCEC	chr13	75362373	Missense_Mutation	novel	G245S	0.49
UCEC	chr13	75326373	Silent	rs143268388	P619P	0.41
UCEC	chr13	75359773	Missense_Mutation	novel	S389F	0.27
UCEC	chr13	75285784	3'UTR	novel		0.3
UCEC	chr13	75285991	3'UTR	novel		0.61
UCEC	chr13	75341211	Missense_Mutation	novel	E509K	0.26
UCEC	chr13	75356155	Missense_Mutation	rs760528845	E423K	0.27
UCEC	chr13	75362099	Missense_Mutation	NA	R336Q	0.38
UCEC	chr13	75310113	Frame_Shift_Del	novel	*L808Sfs32**	0.48
UCEC	chr13	75359771	Nonsense_Mutation	rs771093387	Q390*	0.34
UCEC	chr13	75285679	3'UTR	novel		0.39
UCEC	chr13	75285526	3'UTR	novel		0.3
UCEC	chr13	75286594	3'UTR	novel		0.28
UCEC	chr13	75292112	Missense_Mutation	novel	I1159S	0.27
UCEC	chr13	75327805	Missense_Mutation	novel	R585W	0.28
UCEC	chr13	75286929	Nonsense_Mutation	NA	E1254*	0.32
UCEC	chr13	75309971	Missense_Mutation	novel	R855Q	0.04
UCEC	chr13	75285745	3'UTR	novel		0.19
UCEC	chr13	75324340	Missense_Mutation	novel	L699I	0.13
UCEC	chr13	75362530	Silent	NA	N192N	0.44
UCEC	chr13	75349210	Nonsense_Mutation	novel	C456*	0.28
UCEC	chr13	75292192	Missense_Mutation	NA	M1132I	0.1
UCEC	chr13	75362316	Missense_Mutation	rs769815689	G264R	0.48
UCEC	chr13	75292256	Missense_Mutation	novel	Q1111R	0.32
UCEC	chr13	75286925	Missense_Mutation	NA	K1255R	0.43
UCEC	chr13	75481621	Silent	novel	R49R	0.44
UCEC	chr13	75309972	Nonsense_Mutation	NA	R855*	0.23
UCEC	chr13	75326321	Nonsense_Mutation	rs771771231	R637*	0.24
UCEC	chr13	75294866	Missense_Mutation	NA	A1102T	0.46
UCEC	chr13	75286935	Nonsense_Mutation	novel	E1252*	0.22
UCEC	chr13	75299490	Missense_Mutation	NA	S999Y	0.19
UCEC	chr13	75326355	Silent	rs377713994	T625T	0.25
UCEC	chr13	75337016	Missense_Mutation	novel	E546K	0.55
UCEC	chr13	75362082	Missense_Mutation	rs760407055	A342T	0.54
UCEC	chr13	75481585	Missense_Mutation	novel	E61D	0.4
UCEC	chr13	75286476	3'UTR	novel		0.41
UCEC	chr13	75337013	Missense_Mutation	novel	N547H	0.47
UCEC	chr13	75362162	Missense_Mutation	novel	R315Q	0.35
UCEC	chr13	75289063	Silent	novel	E1178E	0.04
UCEC	chr13	75326328	Silent	rs184072266	P634P	0.25
UCEC	chr13	75285654	3'UTR	novel		0.54
UCEC	chr13	75359810	Missense_Mutation	novel	V377M	0.47
UCEC	chr13	75362512	Missense_Mutation	novel	N198K	0.29
UCS	chr13	75310027	Silent	novel	S836S	0.47

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
CHOL	DEL	0.4167	0.076931
GBM	DEL	0.3466	4.92e-12
PRAD	DEL	0.2967	1.7107e-36

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.0001	Kaplan-Meier Survival Analysis
MESO	0.044	Kaplan-Meier Survival Analysis
ACC	0.0041	Kaplan-Meier Survival Analysis
HNSC	0.034	Kaplan-Meier Survival Analysis
SKCM	0.0047	Kaplan-Meier Survival Analysis
BRCA	0.0065	Kaplan-Meier Survival Analysis
KIRP	0.00018	Kaplan-Meier Survival Analysis
LIHC	0.024	Kaplan-Meier Survival Analysis
LGG	0.0038	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Gene Ontology

Description

Ensembl ID: ENSG00000136111 (Gene tree)
Gene ID: 9882
Gene Symbol: TBC1D4
Alias: KIAA0603|AS160|DKFZp779C0666
Full Name: TBC1 domain family member 4
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 199,144 bases
Position: chr13:75,283,503-75,482,646
Accession: 19165
RBP type: non-canonical RBP
Summary: This gene is a member of the Tre-2/BUB2/CDC16 domain family. The protein encoded by this gene is a Rab-GTPase-activating protein, and contains two phopshotyrosine-binding domains (PTB1 and PTB2), a calmodulin-binding domain (CBD), a Rab-GTPase domain, and multiple AKT phosphomotifs. This protein is thought to play an important role in glucose homeostasis by regulating the insulin-dependent trafficking of the glucose transporter 4 (GLUT4), important for removing glucose from the bloodstream into skeletal muscle and fat tissues. Reduced expression of this gene results in an increase in GLUT4 levels at the plasma membrane, suggesting that this protein is important in intracellular retention of GLUT4 under basal conditions. When exposed to insulin, this protein is phosphorylated, dissociates from GLUT4 vesicles, resulting in increased GLUT4 at the cell surface, and enhanced glucose transport. Phosphorylation of this protein by AKT is required for proper translocation of GLUT4 to the cell surface. Individuals homozygous for a mutation in this gene are at higher risk for type 2 diabetes and have higher levels of circulating glucose and insulin levels after glucose ingestion. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2015]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000648194	TBC1D4-208	6656	XM_017020882	ENSP00000496983	1054 (aa)	XP_016876371	UPI000047D126
ENST00000431480	TBC1D4-204	6347	-	ENSP00000395986	1290 (aa)	-	O60343
ENST00000377625	TBC1D4-201	6182	-	ENSP00000366852	1235 (aa)	-	O60343
ENST00000377636	TBC1D4-202	6364	XM_005266603	ENSP00000366863	1298 (aa)	XP_005266660	O60343
ENST00000488955	TBC1D4-206	336	-	-	- (aa)	-	-
ENST00000478591	TBC1D4-205	759	-	-	- (aa)	-	-
ENST00000413735	TBC1D4-203	847	-	ENSP00000396932	282 (aa)	-	Q5JU47
ENST00000493487	TBC1D4-207	458	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000136111's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa04919	Thyroid hormone signaling pathway	KEGG
hsa04931	Insulin resistance	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000136111	Carotid Stenosis	1.73238930404422E-6	17903303
ENSG00000136111	Carotid Stenosis	6.19547711432883E-7	17903303
ENSG00000136111	Anger	9.514e-005	-
ENSG00000136111	Blood Pressure	4.1860000E-005	-
ENSG00000136111	Blood Pressure	7.4540000E-006	-
ENSG00000136111	Blood Pressure	4.1630000E-006	-
ENSG00000136111	Blood Pressure	5.7390000E-005	-
ENSG00000136111	Blood Pressure	2.5710000E-005	-
ENSG00000136111	Platelet Function Tests	1.8034654E-006	-
ENSG00000136111	Platelet Function Tests	1.8184172E-006	-
ENSG00000136111	Cholesterol, HDL	3.6590000E-006	-
ENSG00000136111	Cholesterol, HDL	1.8180000E-005	-
ENSG00000136111	Venous Thromboembolism	2E-6	28203683

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000136111	rs9573563	13	75480960	?	Mean corpuscular volume	29403010	[0.027-0.051] unit decrease novel	0.03898	EFO_0004526
ENSG00000136111	rs9573563	13	75480960	?	Mean corpuscular hemoglobin	29403010	[0.022-0.046] unit decrease novel	0.03404	EFO_0004527
ENSG00000136111	rs74096215	13	75295026	C	Venous thromboembolism adjusted for sickle cell variant rs77121243-T	28203683	[1.627-3.183]	2.276	EFO_0004286

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000136111's network

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0005096	GTPase activator activity	21873635.	IBA	Function
GO:0005829	cytosol	-	IDA	Component
GO:0006886	intracellular protein transport	21873635.	IBA	Process
GO:0016192	vesicle-mediated transport	22908308.	IMP	Process
GO:0017137	Rab GTPase binding	21873635.	IBA	Function
GO:0031339	negative regulation of vesicle fusion	-	IEA	Process
GO:0031982	vesicle	-	IEA	Component
GO:0032869	cellular response to insulin stimulus	22908308.	IMP	Process
GO:0090630	activation of GTPase activity	21873635.	IBA	Process

EuRBPDB

Note: to get the extension of tumor abbreviations.

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Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.