EuRBPDB

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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
17400356Diverse functions of RNase L and implications in pathology.Biochimie2007 Jun-JulBisbal C-
14695991Mutational analysis of susceptibility genes RNASEL/HPC1, ELAC2/HPC2, and MSR1 in sporadic prostate cancer.Genes Chromosomes Cancer2004 FebNupponen NN-
12590567Implications for RNase L in prostate cancer biology.Biochemistry2003 Feb 25Silverman RH-
18189233RNASEL and RNASEL-inhibitor variation and prostate cancer risk in Afro-Caribbeans.Prostate2008 Mar 1Shea PRdoi: 10.1002/pros.20687.
15330212Lack of association between RNASEL Arg462Gln variant and the risk of breast cancer.Anticancer Res2004 Jul-AugSevin A-
28257035RNase L Suppresses Androgen Receptor Signaling, Cell Migration and Matrix Metalloproteinase Activity in Prostate Cancer Cells.Int J Mol Sci2017 Mar 1Dayal Sdoi: 10.3390/ijms18030529.
20576793Genetic variation in RNASEL associated with prostate cancer risk and progression.Carcinogenesis2010 SepMeyer MSdoi: 10.1093/carcin/bgq132
12022038Analysis of the RNASEL gene in familial and sporadic prostate cancer.Am J Hum Genet2002 JulWang L-
21360564Genetic variation in RNASEL and risk for prostate cancer in a population-based case-control study.Prostate2011 Oct 1Fesinmeyer MDdoi: 10.1002/pros.21370
26771888Key genes involved in the immune response are generally not associated with intraprostatic inflammation in men without a prostate cancer diagnosis: Results from the prostate cancer prevention trial.Prostate2016 MayWinchester DAdoi: 10.1002/pros.23147
11941539Germline alterations of the RNASEL gene, a candidate HPC1 gene at 1q25, in patients and families with prostate cancer.Am J Hum Genet2002 MayRkman A-
21656378RNASEL Asp541Glu and Arg462Gln polymorphisms in prostate cancer risk: evidences from a meta-analysis.Mol Biol Rep2012 MarWei Bdoi: 10.1007/s11033-011-0985-x
19961052[G138A polymorphism of the RNASEL gene and its association with the development of prostate cancer. Preliminary study].Invest Clin2009 SepZabala W-
21665181The effect of TP53 codon 72 and RNASEL codon 462 polymorphisms on the development of cervical cancer in Argentine women.Cancer Genet2011 MayBarbisan Gdoi: 10.1016/j.cancergen.2011.04.001.
17234723Trans-fatty acid intake and increased risk of advanced prostate cancer: modification by RNASEL R462Q variant.Carcinogenesis2007 JunLiu X-
15981205RNASEL germline variants are associated with pancreatic cancer.Int J Cancer2005 Dec 10Bartsch DK-
16114055Association of hereditary prostate cancer gene polymorphic variants with sporadic aggressive prostate carcinoma.Prostate2006 Jan 1Noonan-Wheeler FC-
21846818Genetic variants in the LEPR, CRY1, RNASEL, IL4, and ARVCF genes are prognostic markers of prostate cancer-specific mortality.Cancer Epidemiol Biomarkers Prev2011 SepLin DWdoi: 10.1158/1055-9965.EPI-11-0236
18289577Pathological aggressiveness of prostatic carcinomas related to RNASEL R462Q allelic variants.J Urol2008 AprLarson BTdoi: 10.1016/j.juro.2007.11.078
26263979RNase L Cleavage Products Promote Switch from Autophagy to Apoptosis by Caspase-Mediated Cleavage of Beclin-1.Int J Mol Sci2015 Jul 31Siddiqui MAdoi: 10.3390/ijms160817611.
23098452Evaluation of xenotropic murine leukemia virus and its R426Q polymorphism in patients with prostate cancer in Kerman, southeast of Iran.Asian Pac J Cancer Prev2012Reza MA-
18767027Association of HPC2/ELAC2 and RNASEL non-synonymous variants with prostate cancer risk in African American familial and sporadic cases.Prostate2008 Dec 1Robbins CMdoi: 10.1002/pros.20841.
17020975RNASEL gene polymorphisms and the risk of prostate cancer: a meta-analysis.Clin Cancer Res2006 Oct 1Li H-
16537704RNASEL mutation screening and association study in Ashkenazi and non-Ashkenazi prostate cancer patients.Cancer Epidemiol Biomarkers Prev2006 MarOrr-Urtreger A-
22083266Predictive value in the analysis of RNASEL genotypes in relation to prostate cancer.Prostate Cancer Prostatic Dis2012 JunAlvarez-Cubero MJdoi: 10.1038/pcan.2011.56
26517238RNase L is a negative regulator of cell migration.Oncotarget2015 Dec 29Banerjee Sdoi: 10.18632/oncotarget.6246.
12653398African-American heredity prostate cancer study: a model for genetic research.J Natl Med Assoc2001 AprPowell IJ-
22925698The association of elevated 2',5'-oligoadenylate-dependent RNase L with lung cancer correlated with deficient enzymatic activity and decreased capacity of RNase L dimerization.Lung Cancer2012 OctYin Hdoi: 10.1016/j.lungcan.2012.07.010
12145743A novel founder mutation in the RNASEL gene, 471delAAAG, is associated with prostate cancer in Ashkenazi Jews.Am J Hum Genet2002 OctRennert H-
21221811RNASEL -1385G/A polymorphism and cancer risk: a meta-analysis based on 21 case-control studies.Mol Biol Rep2011 NovZhang LFdoi: 10.1007/s11033-010-0657-2
16869093Involvement of the RNAse L gene in prostate cancer.Bull Soc Sci Med Grand Duche Luxemb2006Kieffer N-
17908993Association of RNASEL variants with prostate cancer risk in Hispanic Caucasians and African Americans.Clin Cancer Res2007 Oct 1Shook SJ-
12915880Role of genetic polymorphisms of the RNASEL gene on familial prostate cancer risk in a Japanese population.Br J Cancer2003 Aug 18Nakazato H-
24224612Association of RNASEL and 8q24 variants with the presence and aggressiveness of hereditary and sporadic prostate cancer in a Hispanic population.J Cell Mol Med2014 JanSan Francisco IFdoi: 10.1111/jcmm.12171
17407163RNASEL Arg462Gln polymorphism and prostate cancer in PLCO.Prostate2007 Jun 1Daugherty SE-
16203993A transcriptional signaling pathway in the IFN system mediated by 2'-5'-oligoadenylate activation of RNase L.Proc Natl Acad Sci U S A2005 Oct 11Malathi K-
15534086Genetic analysis of the RNASEL gene in hereditary, familial, and sporadic prostate cancer.Clin Cancer Res2004 Nov 1Wiklund F-
12415269RNASEL Arg462Gln variant is implicated in up to 13% of prostate cancer cases.Nat Genet2002 DecCasey G-
23382116A single nucleotide polymorphism in inflammatory gene RNASEL predicts outcome after radiation therapy for localized prostate cancer.Clin Cancer Res2013 Mar 15Schoenfeld JDdoi: 10.1158/1078-0432.CCR-12-2718
20086112Single and multivariate associations of MSR1, ELAC2, and RNASEL with prostate cancer in an ethnic diverse cohort of men.Cancer Epidemiol Biomarkers Prev2010 FebBeuten Jdoi: 10.1158/1055-9965.EPI-09-0864
16944274The 471delAAAG mutation and C353T polymorphism in the RNASEL gene in sporadic and inherited cancer in Israel.Fam Cancer2006Dagan E-
28654546Sex-specific effect of RNASEL rs486907 and miR-146a rs2910164 polymorphisms' interaction as a susceptibility factor for melanoma skin cancer.Melanoma Res2017 AugSangalli Adoi: 10.1097/CMR.0000000000000360.
29422015Is RNASEL:p.Glu265* a modifier of early-onset breast cancer risk for carriers of high-risk mutations?BMC Cancer2018 Feb 8Nguyen-Dumont Tdoi: 10.1186/s12885-018-4028-z.

Differential Expression

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
BLCAchr1182586218Missense_MutationNAA197T0.1
BLCAchr1182586109Missense_MutationNAN233S0.2
BLCAchr1182585537Missense_MutationnovelE424Q0.08
BLCAchr1182585547Missense_MutationnovelF420L0.44
BLCAchr1182585590Missense_MutationnovelS406C0.36
BLCAchr1182585840Missense_MutationnovelH323Y0.64
BLCAchr1182586179Missense_MutationnovelL210F0.47
BLCAchr1182586692Missense_MutationNAD39H0.21
BLCAchr1182585840Missense_MutationnovelH323Y0.2
BLCAchr1182582085SilentnovelL580L0.26
BLCAchr1182586063Missense_MutationnovelE248D0.2
BRCAchr1182585809Missense_MutationNAA333D0.15
BRCAchr1182586060Missense_MutationnovelK249N0.09
BRCAchr1182581224Splice_SitenovelX635_splice0.41
BRCAchr1182585410Missense_MutationNAS466L0.11
BRCAchr1182585387Nonsense_MutationnovelE474*0.08
BRCAchr1182585717Missense_MutationnovelF364L0.11
CESCchr1182582214SilentnovelI537I0.08
CESCchr1182585725Missense_MutationnovelL361R0.12
CESCchr1182586389Missense_Mutationrs758397188A140S0.14
CESCchr1182575395SilentnovelC741C0.38
CESCchr1182586098Missense_MutationNAE237Q0.43
COADchr1182585774Frame_Shift_DelNAA345Qfs*30.26
COADchr1182575470Silentrs763696156F716F0.28
COADchr1182586525Silentrs768816440T94T0.11
COADchr1182576365Frame_Shift_DelnovelM644*0.14Ribonuc_2-5A
COADchr1182586165Silentrs148741721D214D0.29
COADchr1182576383Nonsense_MutationNAE638*0.31Ribonuc_2-5A
COADchr1182585963Nonsense_MutationNAE282*0.27
COADchr1182585661Frame_Shift_DelNAF383Sfs*70.23
COADchr1182586631Missense_MutationNAG59D0.29
COADchr1182576343Frame_Shift_InsNAR651Kfs*110.29Ribonuc_2-5A
COADchr1182576364Frame_Shift_InsnovelM644Nfs*30.26Ribonuc_2-5A
COADchr1182585472Missense_MutationNAL445F0.1
COADchr1182586766Missense_Mutationrs766296817T14M0.31
COADchr1182576343Frame_Shift_InsNAR651Kfs*110.33Ribonuc_2-5A
COADchr1182576365Frame_Shift_DelnovelM644*0.22Ribonuc_2-5A
COADchr1182586469Missense_MutationNAS113C0.21
COADchr1182586502Missense_MutationNAA102V0.14
COADchr1182576364Frame_Shift_InsnovelM644Nfs*30.32Ribonuc_2-5A
ESCAchr1182581341Missense_Mutationrs755669893R597W0.32Ribonuc_2-5A
GBMchr1182586470Missense_MutationnovelS113P0.09
GBMchr1182586008Missense_MutationnovelN267D0.06
GBMchr1182585584Missense_MutationnovelL408Q0.04
GBMchr1182585979Frame_Shift_DelnovelL277Cfs*90.04
HNSCchr1182586483SilentnovelL108L0.38
HNSCchr1182582162Missense_MutationnovelP555T0.3
HNSCchr1182586525Silentrs768816440T94T0.45
HNSCchr11825868305'UTRnovel0.44
HNSCchr1182586396SilentnovelK137K0.6
HNSCchr1182586242Missense_MutationnovelD189H0.25
HNSCchr1182586344Nonsense_Mutationrs766020877R155*0.32
HNSCchr1182585792Nonsense_MutationnovelQ339*0.11
KIRCchr1182575428SilentNAA730A0.3
KIRCchr1182582209Missense_Mutationrs762441300F539S0.31
LGGchr1182575555Missense_MutationNAP688L0.41Ribonuc_2-5A
LGGchr1182585572Missense_MutationNAR412Q0.07
LIHCchr1182585365Missense_Mutationrs200144732Y481C0.19
LUADchr1182586305Missense_MutationNAG168W0.26
LUADchr11825753803'UTRnovel0.06
LUADchr1182585774Frame_Shift_DelNAA345Qfs*30.11
LUADchr11825752743'UTRnovel0.1
LUADchr1182585609Missense_MutationNAR400S0.24
LUADchr1182576372Missense_MutationNAM641I0.23Ribonuc_2-5A
LUADchr1182584123SilentNAI508I0.2
LUADchr11825752073'UTRnovel0.29
LUADchr1182585373SilentnovelS478S0.34
LUADchr11825868355'UTRnovel0.1
LUADchr1182585647Missense_MutationnovelQ387P0.2
LUADchr1182586502Missense_MutationNAA102V0.19
LUSCchr1182581339SilentnovelR597R0.3
LUSCchr1182582205Missense_MutationnovelE540D0.25
LUSCchr1182585724SilentnovelL361L0.06
LUSCchr1182575393SilentNA*742*0.2
LUSCchr11825752803'UTRnovel0.15
LUSCchr11825752963'UTRnovel0.16
LUSCchr1182575415Missense_MutationNAG735W0.3
LUSCchr1182582081Missense_MutationnovelG582C0.19
LUSCchr11825753433'UTRnovel0.13
LUSCchr1182586804Translation_Start_SitenovelM1?0.23
LUSCchr11825753493'UTRnovel0.48
LUSCchr1182586306SilentnovelG167G0.09
LUSCchr1182585495Nonsense_MutationNAE438*0.46
LUSCchr1182586501Silentrs200161417A102A0.25
LUSCchr1182586318SilentnovelR163R0.42
LUSCchr1182575546Missense_MutationNAY691C0.42Ribonuc_2-5A
LUSCchr1182586437Missense_MutationnovelY124H0.5
LUSCchr1182585949Missense_MutationnovelK286N0.12
OVchr1182586143Missense_MutationNAT222S0.46
OVchr1182582161Missense_MutationnovelP555Q0.06
OVchr1182576389Missense_MutationnovelI636V0.09Ribonuc_2-5A
OVchr1182576268Missense_MutationNAE676G0.26Ribonuc_2-5A
OVchr1182575559Missense_MutationNAD687N0.44Ribonuc_2-5A
OVchr1182576317Missense_MutationNAG660C0.37Ribonuc_2-5A
OVchr1182582143In_Frame_InsnovelD561delinsGCLLLLSEAGH0.03
PAADchr1182586021Missense_MutationnovelE262D0.09
PRADchr1182581354SilentNAR592R0.2
PRADchr1182586141Silentrs141997272T222T0.4
PRADchr1182586461Missense_MutationnovelA116T0.38
READchr1182584110Missense_MutationnovelD513N0.04
READchr1182576358Missense_MutationNAK646T0.2Ribonuc_2-5A
READchr1182576387Missense_MutationNAI636M0.31Ribonuc_2-5A
SARCchr1182586569Missense_MutationnovelR80C0.14
SARCchr1182575530SilentnovelF696F0.19
SARCchr1182579989Intronnovel0.22
SKCMchr1182586709Missense_MutationNAV33A0.44
SKCMchr1182586399Silentrs757657442G136G0.42
SKCMchr1182585897Missense_MutationnovelL304F0.37
SKCMchr1182586378SilentNAF143F0.24
SKCMchr1182586755Missense_MutationNAG18S0.11
SKCMchr1182575470Silentrs763696156F716F0.22
SKCMchr1182586088Missense_MutationNAK240T0.15
SKCMchr1182581288SilentNAI614I0.46
SKCMchr1182582124SilentNAF567F0.38
SKCMchr1182586519SilentnovelF96F0.55
SKCMchr1182582199SilentNAL542L0.47
SKCMchr1182586474SilentNAF111F0.53
SKCMchr1182581285Silentrs749257214L615L0.38
SKCMchr1182585943SilentNAI288I0.38
SKCMchr11825868445'UTRnovel0.71
SKCMchr1182585427Missense_MutationNAF460L0.15
SKCMchr1182586424Missense_MutationNAA128V0.64
SKCMchr1182586781Missense_MutationNAP9L0.33
SKCMchr1182585428Missense_MutationNAF460S0.07
SKCMchr1182586091Missense_MutationnovelG239E0.34
SKCMchr1182586092Missense_MutationnovelG239R0.33
SKCMchr1182586246SilentNAL187L0.29
SKCMchr1182582132Missense_Mutationrs200397730R565C0.26
SKCMchr1182575414Missense_MutationNAG735E0.25
SKCMchr1182582174Missense_MutationNAV551I0.13
SKCMchr1182582132Missense_Mutationrs200397730R565C0.42
SKCMchr1182586474SilentNAF111F0.39
STADchr1182586525Silentrs768816440T94T0.17
STADchr1182585721Missense_MutationnovelK362N0.24
STADchr1182586702Silentrs780021840N35N0.25
STADchr1182586284Missense_MutationNAA175T0.16
STADchr1182581336Silentrs775665408N598N0.08
STADchr1182585980Missense_MutationNAA276E0.15
STADchr1182586069SilentNAA246A0.2
STADchr1182586137SilentNAL224L0.17
STADchr1182581343Missense_MutationNAL596R0.04Ribonuc_2-5A
STADchr1182575565Frame_Shift_DelnovelI685Lfs*160.32Ribonuc_2-5A
STADchr1182581276Silentrs572503904L618L0.24
UCECchr1182585608Missense_MutationNAR400H0.51
UCECchr1182585879Missense_Mutationrs747178598R310W0.18
UCECchr1182576371Missense_MutationNAK642E0.32Ribonuc_2-5A
UCECchr1182579733Intronnovel0.24
UCECchr11825751723'UTRnovel0.25
UCECchr1182576376Missense_MutationnovelV640A0.29Ribonuc_2-5A
UCECchr11825752543'UTRnovel0.5
UCECchr11825753493'UTRnovel0.34
UCECchr1182579924Intronnovel0.39
UCECchr1182579980Intronnovel0.39
UCECchr1182585981Missense_MutationnovelA276T0.27
UCECchr1182576358Missense_MutationNAK646T0.24Ribonuc_2-5A
UCECchr1182586141Silentrs141997272T222T0.06
UCECchr1182585354Missense_MutationNAD485Y0.15
UCECchr1182586512Missense_MutationNAA99T0.15
UCECchr11825868535'UTRnovel0.14
UCECchr1182584091Missense_MutationNAR519K0.34
UCECchr1182586449Nonsense_MutationnovelE120*0.49
UCECchr1182585582Nonsense_MutationNAQ409*0.25
UCECchr1182586103Frame_Shift_InsnovelR235Mfs*330.13
UCECchr1182582184SilentnovelN547N0.27
UCECchr1182586669Missense_MutationnovelE46D0.33
UCECchr1182586266Missense_Mutationrs779087511V181I0.33
UCECchr1182575487Nonsense_MutationnovelE711*0.32Ribonuc_2-5A
UCECchr11825752133'UTRnovel0.73
UCECchr1182585924Missense_MutationnovelR295C0.39
UCECchr1182585943SilentNAI288I0.39
UCECchr1182576358Missense_MutationNAK646T0.36Ribonuc_2-5A
UCECchr1182579787Intronnovel0.24
UCECchr1182581248Missense_MutationnovelS628R0.37Ribonuc_2-5A
UCECchr1182581351SilentnovelY593Y0.38
UCECchr1182586404Missense_MutationnovelY135H0.27
UCECchr1182585364SilentNAY481Y0.25
UCECchr11825753893'UTRnovel0.44
UCECchr1182586012SilentnovelE265E0.39
UCECchr1182585528Missense_MutationnovelR427G0.25
UCECchr1182586611Missense_Mutationrs745739936A66T0.27
UCECchr1182585415Silentrs757258805V464V0.44
UCECchr1182585478Silentrs777270662A443A0.34
UCECchr1182586525Silentrs768816440T94T0.21
UCECchr1182586523Missense_MutationnovelP95H0.19
UCECchr1182581345Silentrs748847842T595T0.46
UCECchr1182586039SilentnovelQ256Q0.38
UCECchr1182586155Missense_MutationNAV218M0.27
UCECchr1182585328Splice_RegionNAI493I0.18
UCECchr1182575494SilentnovelQ708Q0.43
UCECchr1182581330SilentnovelG600G0.61
UCECchr1182586343Missense_MutationNAR155Q0.24
UCECchr1182585788Missense_MutationNAS340N0.35
UCECchr11825868365'UTRnovel0.14
UCECchr11825751563'UTRnovel0.2
UCECchr1182586464Missense_MutationnovelG115R0.24
UCECchr1182575476SilentnovelK714K0.27
UCECchr1182576364Frame_Shift_InsnovelM644Nfs*30.32Ribonuc_2-5A
UCECchr1182586650Missense_MutationNAF53L0.14
UCECchr1182586611Missense_Mutationrs745739936A66T0.3

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
DLBCDEL0.04170.0017831
KIRCAMP0.0890.059566
PAADAMP0.22830.085665
TGCTAMP0.34670.088103
THCAAMP0.05010.075436

Survival Analysis
CancerP-value Q-value
KIRC0.0027

Kaplan-Meier Survival Analysis

SARC0.0001

Kaplan-Meier Survival Analysis

MESO0.005

Kaplan-Meier Survival Analysis

UCS0.05

Kaplan-Meier Survival Analysis

SKCM0.018

Kaplan-Meier Survival Analysis

LGG0.0048

Kaplan-Meier Survival Analysis

OV0.025

Kaplan-Meier Survival Analysis

Drugs

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Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBDs
  • Literatures
  • Expression
  • Transcripts
  • Gene Model
  • Pathways
  • Phenotypes
  • GWAS
  • PPI
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000135828 (Gene tree)
Gene ID
6041
Gene Symbol
RNASEL
Alias
RNS4|PRCA1
Full Name
ribonuclease L
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Minus strand
Length
15,652 bases
Position
chr1:182,573,634-182,589,285
Accession
10050
RBP type
canonical RBP
Summary
This gene encodes a component of the interferon-regulated 2-5A system that functions in the antiviral and antiproliferative roles of interferons. Mutations in this gene have been associated with predisposition to prostate cancer and this gene is a candidate for the hereditary prostate cancer 1 (HPC1) allele. [provided by RefSeq, Jul 2008]
RNA binding domains(RBDs)
Protein IDDomain Pfam IDE-value Domain number Total number
ENSP00000356530Ribonuc_2-5APF06479.125.3e-2611

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
15063798Expression of interferon-inducible recombinant human RNase L causes RNA degradation and inhibition of cell growth in Escherichia coli.Biochem Biophys Res Commun2004 Apr 30Pandey M-
84633022',5'-Oligoadenylate-dependent RNase L is a dimer of regulatory and catalytic subunits.J Biol Chem1993 Apr 15Salehzada T-
16627618The primary function of RNA binding by the influenza A virus NS1 protein in infected cells: Inhibiting the 2'-5' oligo (A) synthetase/RNase L pathway.Proc Natl Acad Sci U S A2006 May 2Min JY-
10926206Characterization of RNABP, an RNA binding protein that associates with RNase L.J Interferon Cytokine Res2000 JulLe Roy F-
19252527RNase L downmodulation of the RNA-binding protein, HuR, and cellular growth.Oncogene2009 Apr 16Al-Ahmadi Wdoi: 10.1038/onc.2009.16
25301952RNase L attenuates mitogen-stimulated gene expression via transcriptional and post-transcriptional mechanisms to limit the proliferative response.J Biol Chem2014 Nov 28Brennan-Laun SEdoi: 10.1074/jbc.M114.589556
21813458Nucleoside modifications in RNA limit activation of 2'-5'-oligoadenylate synthetase and increase resistance to cleavage by RNase L.Nucleic Acids Res2011 NovAnderson BRdoi: 10.1093/nar/gkr586
24659782Transcription of angiogenin and ribonuclease 4 is regulated by RNA polymerase III elements and a CCCTC binding factor (CTCF)-dependent intragenic chromatin loop.J Biol Chem2014 May 2Sheng Jdoi: 10.1074/jbc.M114.551762
3745989The effect of ammonium ion on the induction of (2'-5')-(A)n synthetase and (2'-5')-(A)n-dependent endoribonuclease activities by interferon in mouse BALB/C 3T3 cells.J Interferon Res1986 JunWu JM-
3427064Phosphorothioate analogues of 2',5'-oligoadenylate. Enzymatic synthesis, properties, and biological activities of 2',5'-phosphorothioates from adenosine 5'-O-(2-thiotriphosphate) and adenosine 5'-O-(3-thiotriphosphate).Biochemistry1987 Nov 3Suhadolnik RJ-
2422811Inhibition of 2',5'-oligo(A)-dependent endoribonuclease by 2',5'-oligo(A) degradation products.Virology1986 JunWilliams GJ-
9268370A bipartite model of 2-5A-dependent RNase L.J Biol Chem1997 Aug 29Dong B-
15206938Contribution of Tyr712 and Phe716 to the activity of human RNase L.Eur J Biochem2004 JulNakanishi M-
18426919A viral RNA competitively inhibits the antiviral endoribonuclease domain of RNase L.RNA2008 JunTownsend HLdoi: 10.1261/rna.958908
17145707Selection and cloning of poly(rC)-binding protein 2 and Raf kinase inhibitor protein RNA activators of 2',5'-oligoadenylate synthetase from prostate cancer cells.Nucleic Acids Res2006Molinaro RJ-
16978086Human telomerase RNA degradation by 2'-5'-linked oligoadenylate antisense chimeras in a cell-free system, cultured tumor cells, and murine xenograft models.Oligonucleotides2006 FallParanjape JM-
21190483New insights into the role of RNase L in innate immunity.J Interferon Cytokine Res2011 JanChakrabarti Adoi: 10.1089/jir.2010.0120
25275129The 2'-5'-oligoadenylate synthetase 3 enzyme potently synthesizes the 2'-5'-oligoadenylates required for RNase L activation.J Virol2014 DecIbsen MSdoi: 10.1128/JVI.01763-14
23608948Mechanistic insights into RNase L through use of an MDMX-derived multi-functional protein domain.Biochim Biophys Acta2013 AugGarvie CWdoi: 10.1016/j.bbapap.2013.04.010
25871524Characterization of the termini of the West Nile virus genome and their interactions with the small isoform of the 2' 5'-oligoadenylate synthetase family.J Struct Biol2015 MayDeo Sdoi: 10.1016/j.jsb.2015.04.005
25752600OASes and STING: adaptive evolution in concert.Genome Biol Evol2015 Mar 9Mozzi Adoi: 10.1093/gbe/evv046.
30209174Human Host Range Restriction of the Vaccinia Virus C7/K1 Double Deletion Mutant Is Mediated by an Atypical Mode of Translation Inhibition.J Virol2018 Nov 12Sivan Gdoi: 10.1128/JVI.01329-18
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Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000539397RNASEL-2024046-ENSP00000440844652 (aa)-Q05823
ENST00000367559RNASEL-2014238-ENSP00000356530741 (aa)-Q05823
Gene Model
Click here to download ENSG00000135828's gene model file
Pathways
Pathway IDPathway NameSource
hsa04621NOD-like receptor signaling pathwayKEGG
hsa05160Hepatitis CKEGG
hsa05164Influenza AKEGG
hsa05168Herpes simplex virus 1 infectionKEGG
Phenotypes
ensgIDTraitpValuePubmed ID
ENSG00000135828Multiple Sclerosis6E-923412934
ENSG00000135828Circadian Rhythm7E-2827494321
ENSG00000135828Circadian Rhythm3E-1227494321
ENSG00000135828Circadian Rhythm7E-1826835600
GWAS
ensgIDSNPChromosomePositionSNP-risk TraitPubmedID95% CIOr or BEAT EFO ID
ENSG00000135828rs5161341182584558CChronotype27494321[0.059-0.103] unit increase0.081EFO_0004354
ENSG00000135828rs5161341182584558CMorning vs. evening chronotype27494321[1.15-1.27]1.21EFO_0004354
ENSG00000135828rs127366891182580594CMorning vs. evening chronotype268356001.3513513EFO_0004354
ENSG00000135828rs5332591182579884?Multiple sclerosis23412934EFO_0003885
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000135828's network

* RBP PPI network refers to all genes directly bind to RBP
Orthologs
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000135828RNASEL9873.197ENSAMEG00000007756RNASEL9971.905Ailuropoda_melanoleuca
ENSG00000135828RNASEL9144.279ENSAPLG00000009854RNASEL9943.217Anas_platyrhynchos
ENSG00000135828RNASEL9445.920ENSACAG00000004961RNASEL9744.167Anolis_carolinensis
ENSG00000135828RNASEL10087.584ENSANAG00000036044RNASEL10087.584Aotus_nancymaae
ENSG00000135828RNASEL9871.787ENSBTAG00000009091RNASEL9971.547Bos_taurus
ENSG00000135828RNASEL10086.119ENSCJAG00000004725RNASEL10086.119Callithrix_jacchus
ENSG00000135828RNASEL9871.473ENSCAFG00000013121RNASEL9971.409Canis_familiaris
ENSG00000135828RNASEL9871.547ENSCAFG00020014858RNASEL10071.324Canis_lupus_dingo
ENSG00000135828RNASEL9870.822ENSCHIG00000021530RNASEL9970.822Capra_hircus
ENSG00000135828RNASEL10074.832ENSTSYG00000000281RNASEL10074.832Carlito_syrichta
ENSG00000135828RNASEL10087.736ENSCCAG00000032500RNASEL10087.736Cebus_capucinus
ENSG00000135828RNASEL10092.848ENSCATG00000038808RNASEL10092.848Cercocebus_atys
ENSG00000135828RNASEL10067.251ENSCLAG00000011944RNASEL10067.251Chinchilla_lanigera
ENSG00000135828RNASEL10092.982ENSCSAG00000012514RNASEL10092.982Chlorocebus_sabaeus
ENSG00000135828RNASEL9846.201ENSCPBG00000015776-9946.101Chrysemys_picta_bellii
ENSG00000135828RNASEL9893.526ENSCANG00000041251RNASEL10093.526Colobus_angolensis_palliatus
ENSG00000135828RNASEL9864.789ENSCGRG00001008939Rnasel9964.247Cricetulus_griseus_chok1gshd
ENSG00000135828RNASEL9864.789ENSCGRG00000009259Rnasel9964.247Cricetulus_griseus_crigri
ENSG00000135828RNASEL9871.698ENSDNOG00000017705RNASEL9971.331Dasypus_novemcinctus
ENSG00000135828RNASEL9467.770ENSDORG00000005886Rnasel9967.770Dipodomys_ordii
ENSG00000135828RNASEL9067.836ENSETEG00000008370RNASEL8267.836Echinops_telfairi
ENSG00000135828RNASEL9975.311ENSEASG00005006600RNASEL9976.976Equus_asinus_asinus
ENSG00000135828RNASEL9975.466ENSECAG00000015188RNASEL9977.254Equus_caballus
ENSG00000135828RNASEL9859.341ENSEEUG00000011471RNASEL10058.480Erinaceus_europaeus
ENSG00000135828RNASEL9875.000ENSFCAG00000024554RNASEL10074.207Felis_catus
ENSG00000135828RNASEL9442.834ENSFALG00000008002RNASEL9741.702Ficedula_albicollis
ENSG00000135828RNASEL8565.583ENSFDAG00000016599RNASEL10065.583Fukomys_damarensis
ENSG00000135828RNASEL9143.163ENSGALG00000042986RNASEL9741.931Gallus_gallus
ENSG00000135828RNASEL10098.516ENSGGOG00000023414RNASEL10098.516Gorilla_gorilla
ENSG00000135828RNASEL9867.969ENSHGLG00100009841RNASEL9968.824Heterocephalus_glaber_male
ENSG00000135828RNASEL9973.378ENSSTOG00000007352RNASEL9973.378Ictidomys_tridecemlineatus
ENSG00000135828RNASEL9863.043ENSJJAG00000013606Rnasel9856.667Jaculus_jaculus
ENSG00000135828RNASEL9542.897ENSLACG00000000804RNASEL9942.897Latimeria_chalumnae
ENSG00000135828RNASEL9968.054ENSLAFG00000022307RNASEL9968.054Loxodonta_africana
ENSG00000135828RNASEL10092.173ENSMFAG00000044965RNASEL10092.173Macaca_fascicularis
ENSG00000135828RNASEL10092.308ENSMNEG00000032732RNASEL10092.308Macaca_nemestrina
ENSG00000135828RNASEL10092.713ENSMLEG00000037368RNASEL10092.713Mandrillus_leucophaeus
ENSG00000135828RNASEL9839.918ENSMGAG00000003316RNASEL9939.918Meleagris_gallopavo
ENSG00000135828RNASEL9863.380ENSMAUG00000020643Rnasel9864.078Mesocricetus_auratus
ENSG00000135828RNASEL9977.328ENSMICG00000026907RNASEL9977.328Microcebus_murinus
ENSG00000135828RNASEL9764.771ENSMOCG00000009828Rnasel9864.771Microtus_ochrogaster
ENSG00000135828RNASEL9755.230ENSMODG00000006829RNASEL9455.230Monodelphis_domestica
ENSG00000135828RNASEL9865.247MGP_CAROLIEiJ_G0014713Rnasel9768.636Mus_caroli
ENSG00000135828RNASEL9964.276ENSMUSG00000066800Rnasel9966.667Mus_musculus
ENSG00000135828RNASEL9963.488MGP_PahariEiJ_G0027949Rnasel9964.201Mus_pahari
ENSG00000135828RNASEL9863.793MGP_SPRETEiJ_G0015520Rnasel9964.763Mus_spretus
ENSG00000135828RNASEL10069.372ENSMPUG00000011522RNASEL9969.793Mustela_putorius_furo
ENSG00000135828RNASEL10071.640ENSMLUG00000010098RNASEL10071.640Myotis_lucifugus
ENSG00000135828RNASEL10095.007ENSNLEG00000018010RNASEL10095.007Nomascus_leucogenys
ENSG00000135828RNASEL10065.903ENSODEG00000002238RNASEL10065.903Octodon_degus
ENSG00000135828RNASEL9555.099ENSOANG00000000982RNASEL10055.099Ornithorhynchus_anatinus
ENSG00000135828RNASEL9959.134ENSOCUG00000015922RNASEL10059.134Oryctolagus_cuniculus
ENSG00000135828RNASEL10078.437ENSOGAG00000002612RNASEL10078.437Otolemur_garnettii
ENSG00000135828RNASEL10071.795ENSOARG00000018978RNASEL10071.795Ovis_aries
ENSG00000135828RNASEL10097.436ENSPPAG00000029542RNASEL10097.436Pan_paniscus
ENSG00000135828RNASEL9875.314ENSPPRG00000003895RNASEL10074.621Panthera_pardus
ENSG00000135828RNASEL9873.585ENSPTIG00000017036RNASEL10073.103Panthera_tigris_altaica
ENSG00000135828RNASEL10097.301ENSPTRG00000001755RNASEL10097.301Pan_troglodytes
ENSG00000135828RNASEL10092.713ENSPANG00000016769RNASEL10092.713Papio_anubis
ENSG00000135828RNASEL9743.876ENSPSIG00000008045-9944.061Pelodiscus_sinensis
ENSG00000135828RNASEL9649.373ENSPSIG00000007735-9948.352Pelodiscus_sinensis
ENSG00000135828RNASEL9965.438ENSPEMG00000012855Rnasel9867.036Peromyscus_maniculatus_bairdii
ENSG00000135828RNASEL9855.329ENSPCIG00000018112RNASEL9955.895Phascolarctos_cinereus
ENSG00000135828RNASEL10095.951ENSPPYG00000000435RNASEL10095.951Pongo_abelii
ENSG00000135828RNASEL6265.352ENSPCAG00000015612-6265.634Procavia_capensis
ENSG00000135828RNASEL10080.162ENSPCOG00000013879RNASEL10080.162Propithecus_coquereli
ENSG00000135828RNASEL9971.644ENSPVAG00000010445RNASEL9971.644Pteropus_vampyrus
ENSG00000135828RNASEL9963.008ENSRNOG00000027017Rnasel9963.008Rattus_norvegicus
ENSG00000135828RNASEL10094.197ENSRBIG00000044741RNASEL10094.197Rhinopithecus_bieti
ENSG00000135828RNASEL10094.062ENSRROG00000035978RNASEL10094.062Rhinopithecus_roxellana
ENSG00000135828RNASEL10087.197ENSSBOG00000034574RNASEL10087.197Saimiri_boliviensis_boliviensis
ENSG00000135828RNASEL9871.698ENSSSCG00000015549RNASEL9970.755Sus_scrofa
ENSG00000135828RNASEL8575.472ENSTBEG00000004013RNASEL8575.472Tupaia_belangeri
ENSG00000135828RNASEL9969.147ENSTTRG00000007635RNASEL10069.147Tursiops_truncatus
ENSG00000135828RNASEL9873.824ENSUMAG00000016510RNASEL9972.323Ursus_maritimus
ENSG00000135828RNASEL9871.823ENSVVUG00000008895RNASEL9971.823Vulpes_vulpes
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0003723RNA binding7514601.IDAFunction
GO:0004521endoribonuclease activity7514601.NASFunction
GO:0004672protein kinase activity-IEAFunction
GO:0005515protein binding7539425.20875083.IPIFunction
GO:0005524ATP binding-IEAFunction
GO:0005575cellular_component-NDComponent
GO:0005759mitochondrial matrix-TASComponent
GO:0005829cytosol-TASComponent
GO:0006364rRNA processing-IEAProcess
GO:0006397mRNA processing-IEAProcess
GO:0006468protein phosphorylation7514601.NASProcess
GO:0016363nuclear matrix-IEAComponent
GO:0019843rRNA binding-IEAFunction
GO:0043021ribonucleoprotein complex binding-IEAFunction
GO:0043488regulation of mRNA stability-IEAProcess
GO:0045071negative regulation of viral genome replication19923450.IDAProcess
GO:0045444fat cell differentiation-IEAProcess
GO:0045944positive regulation of transcription by RNA polymerase II19245366.IDAProcess
GO:0046326positive regulation of glucose import-IEAProcess
GO:0046872metal ion binding-IEAFunction
GO:0051607defense response to virus19923450.IDAProcess
GO:0051607defense response to virus-TASProcess
GO:0060337type I interferon signaling pathway-TASProcess
GO:0060338regulation of type I interferon-mediated signaling pathway-TASProcess
GO:0090502RNA phosphodiester bond hydrolysis, endonucleolytic-IEAProcess
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