EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
17400356	Diverse functions of RNase L and implications in pathology.	Biochimie	2007 Jun-Jul	Bisbal C	-
14695991	Mutational analysis of susceptibility genes RNASEL/HPC1, ELAC2/HPC2, and MSR1 in sporadic prostate cancer.	Genes Chromosomes Cancer	2004 Feb	Nupponen NN	-
12590567	Implications for RNase L in prostate cancer biology.	Biochemistry	2003 Feb 25	Silverman RH	-
18189233	RNASEL and RNASEL-inhibitor variation and prostate cancer risk in Afro-Caribbeans.	Prostate	2008 Mar 1	Shea PR	doi: 10.1002/pros.20687.
15330212	Lack of association between RNASEL Arg462Gln variant and the risk of breast cancer.	Anticancer Res	2004 Jul-Aug	Sevin A	-
28257035	RNase L Suppresses Androgen Receptor Signaling, Cell Migration and Matrix Metalloproteinase Activity in Prostate Cancer Cells.	Int J Mol Sci	2017 Mar 1	Dayal S	doi: 10.3390/ijms18030529.
20576793	Genetic variation in RNASEL associated with prostate cancer risk and progression.	Carcinogenesis	2010 Sep	Meyer MS	doi: 10.1093/carcin/bgq132
12022038	Analysis of the RNASEL gene in familial and sporadic prostate cancer.	Am J Hum Genet	2002 Jul	Wang L	-
21360564	Genetic variation in RNASEL and risk for prostate cancer in a population-based case-control study.	Prostate	2011 Oct 1	Fesinmeyer MD	doi: 10.1002/pros.21370
26771888	Key genes involved in the immune response are generally not associated with intraprostatic inflammation in men without a prostate cancer diagnosis: Results from the prostate cancer prevention trial.	Prostate	2016 May	Winchester DA	doi: 10.1002/pros.23147
11941539	Germline alterations of the RNASEL gene, a candidate HPC1 gene at 1q25, in patients and families with prostate cancer.	Am J Hum Genet	2002 May	Rkman A	-
21656378	RNASEL Asp541Glu and Arg462Gln polymorphisms in prostate cancer risk: evidences from a meta-analysis.	Mol Biol Rep	2012 Mar	Wei B	doi: 10.1007/s11033-011-0985-x
19961052	[G138A polymorphism of the RNASEL gene and its association with the development of prostate cancer. Preliminary study].	Invest Clin	2009 Sep	Zabala W	-
21665181	The effect of TP53 codon 72 and RNASEL codon 462 polymorphisms on the development of cervical cancer in Argentine women.	Cancer Genet	2011 May	Barbisan G	doi: 10.1016/j.cancergen.2011.04.001.
17234723	Trans-fatty acid intake and increased risk of advanced prostate cancer: modification by RNASEL R462Q variant.	Carcinogenesis	2007 Jun	Liu X	-
15981205	RNASEL germline variants are associated with pancreatic cancer.	Int J Cancer	2005 Dec 10	Bartsch DK	-
16114055	Association of hereditary prostate cancer gene polymorphic variants with sporadic aggressive prostate carcinoma.	Prostate	2006 Jan 1	Noonan-Wheeler FC	-
21846818	Genetic variants in the LEPR, CRY1, RNASEL, IL4, and ARVCF genes are prognostic markers of prostate cancer-specific mortality.	Cancer Epidemiol Biomarkers Prev	2011 Sep	Lin DW	doi: 10.1158/1055-9965.EPI-11-0236
18289577	Pathological aggressiveness of prostatic carcinomas related to RNASEL R462Q allelic variants.	J Urol	2008 Apr	Larson BT	doi: 10.1016/j.juro.2007.11.078
26263979	RNase L Cleavage Products Promote Switch from Autophagy to Apoptosis by Caspase-Mediated Cleavage of Beclin-1.	Int J Mol Sci	2015 Jul 31	Siddiqui MA	doi: 10.3390/ijms160817611.
23098452	Evaluation of xenotropic murine leukemia virus and its R426Q polymorphism in patients with prostate cancer in Kerman, southeast of Iran.	Asian Pac J Cancer Prev	2012	Reza MA	-
18767027	Association of HPC2/ELAC2 and RNASEL non-synonymous variants with prostate cancer risk in African American familial and sporadic cases.	Prostate	2008 Dec 1	Robbins CM	doi: 10.1002/pros.20841.
17020975	RNASEL gene polymorphisms and the risk of prostate cancer: a meta-analysis.	Clin Cancer Res	2006 Oct 1	Li H	-
16537704	RNASEL mutation screening and association study in Ashkenazi and non-Ashkenazi prostate cancer patients.	Cancer Epidemiol Biomarkers Prev	2006 Mar	Orr-Urtreger A	-
22083266	Predictive value in the analysis of RNASEL genotypes in relation to prostate cancer.	Prostate Cancer Prostatic Dis	2012 Jun	Alvarez-Cubero MJ	doi: 10.1038/pcan.2011.56
26517238	RNase L is a negative regulator of cell migration.	Oncotarget	2015 Dec 29	Banerjee S	doi: 10.18632/oncotarget.6246.
12653398	African-American heredity prostate cancer study: a model for genetic research.	J Natl Med Assoc	2001 Apr	Powell IJ	-
22925698	The association of elevated 2',5'-oligoadenylate-dependent RNase L with lung cancer correlated with deficient enzymatic activity and decreased capacity of RNase L dimerization.	Lung Cancer	2012 Oct	Yin H	doi: 10.1016/j.lungcan.2012.07.010
12145743	A novel founder mutation in the RNASEL gene, 471delAAAG, is associated with prostate cancer in Ashkenazi Jews.	Am J Hum Genet	2002 Oct	Rennert H	-
21221811	RNASEL -1385G/A polymorphism and cancer risk: a meta-analysis based on 21 case-control studies.	Mol Biol Rep	2011 Nov	Zhang LF	doi: 10.1007/s11033-010-0657-2
16869093	Involvement of the RNAse L gene in prostate cancer.	Bull Soc Sci Med Grand Duche Luxemb	2006	Kieffer N	-
17908993	Association of RNASEL variants with prostate cancer risk in Hispanic Caucasians and African Americans.	Clin Cancer Res	2007 Oct 1	Shook SJ	-
12915880	Role of genetic polymorphisms of the RNASEL gene on familial prostate cancer risk in a Japanese population.	Br J Cancer	2003 Aug 18	Nakazato H	-
24224612	Association of RNASEL and 8q24 variants with the presence and aggressiveness of hereditary and sporadic prostate cancer in a Hispanic population.	J Cell Mol Med	2014 Jan	San Francisco IF	doi: 10.1111/jcmm.12171
17407163	RNASEL Arg462Gln polymorphism and prostate cancer in PLCO.	Prostate	2007 Jun 1	Daugherty SE	-
16203993	A transcriptional signaling pathway in the IFN system mediated by 2'-5'-oligoadenylate activation of RNase L.	Proc Natl Acad Sci U S A	2005 Oct 11	Malathi K	-
15534086	Genetic analysis of the RNASEL gene in hereditary, familial, and sporadic prostate cancer.	Clin Cancer Res	2004 Nov 1	Wiklund F	-
12415269	RNASEL Arg462Gln variant is implicated in up to 13% of prostate cancer cases.	Nat Genet	2002 Dec	Casey G	-
23382116	A single nucleotide polymorphism in inflammatory gene RNASEL predicts outcome after radiation therapy for localized prostate cancer.	Clin Cancer Res	2013 Mar 15	Schoenfeld JD	doi: 10.1158/1078-0432.CCR-12-2718
20086112	Single and multivariate associations of MSR1, ELAC2, and RNASEL with prostate cancer in an ethnic diverse cohort of men.	Cancer Epidemiol Biomarkers Prev	2010 Feb	Beuten J	doi: 10.1158/1055-9965.EPI-09-0864
16944274	The 471delAAAG mutation and C353T polymorphism in the RNASEL gene in sporadic and inherited cancer in Israel.	Fam Cancer	2006	Dagan E	-
28654546	Sex-specific effect of RNASEL rs486907 and miR-146a rs2910164 polymorphisms' interaction as a susceptibility factor for melanoma skin cancer.	Melanoma Res	2017 Aug	Sangalli A	doi: 10.1097/CMR.0000000000000360.
29422015	Is RNASEL:p.Glu265* a modifier of early-onset breast cancer risk for carriers of high-risk mutations?	BMC Cancer	2018 Feb 8	Nguyen-Dumont T	doi: 10.1186/s12885-018-4028-z.

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
BLCA	chr1	182586218	Missense_Mutation	NA	A197T	0.1
BLCA	chr1	182586109	Missense_Mutation	NA	N233S	0.2
BLCA	chr1	182585537	Missense_Mutation	novel	E424Q	0.08
BLCA	chr1	182585547	Missense_Mutation	novel	F420L	0.44
BLCA	chr1	182585590	Missense_Mutation	novel	S406C	0.36
BLCA	chr1	182585840	Missense_Mutation	novel	H323Y	0.64
BLCA	chr1	182586179	Missense_Mutation	novel	L210F	0.47
BLCA	chr1	182586692	Missense_Mutation	NA	D39H	0.21
BLCA	chr1	182585840	Missense_Mutation	novel	H323Y	0.2
BLCA	chr1	182582085	Silent	novel	L580L	0.26
BLCA	chr1	182586063	Missense_Mutation	novel	E248D	0.2
BRCA	chr1	182585809	Missense_Mutation	NA	A333D	0.15
BRCA	chr1	182586060	Missense_Mutation	novel	K249N	0.09
BRCA	chr1	182581224	Splice_Site	novel	X635_splice	0.41
BRCA	chr1	182585410	Missense_Mutation	NA	S466L	0.11
BRCA	chr1	182585387	Nonsense_Mutation	novel	E474*	0.08
BRCA	chr1	182585717	Missense_Mutation	novel	F364L	0.11
CESC	chr1	182582214	Silent	novel	I537I	0.08
CESC	chr1	182585725	Missense_Mutation	novel	L361R	0.12
CESC	chr1	182586389	Missense_Mutation	rs758397188	A140S	0.14
CESC	chr1	182575395	Silent	novel	C741C	0.38
CESC	chr1	182586098	Missense_Mutation	NA	E237Q	0.43
COAD	chr1	182585774	Frame_Shift_Del	NA	*A345Qfs3**	0.26
COAD	chr1	182575470	Silent	rs763696156	F716F	0.28
COAD	chr1	182586525	Silent	rs768816440	T94T	0.11
COAD	chr1	182576365	Frame_Shift_Del	novel	M644*	0.14	Ribonuc_2-5A
COAD	chr1	182586165	Silent	rs148741721	D214D	0.29
COAD	chr1	182576383	Nonsense_Mutation	NA	E638*	0.31	Ribonuc_2-5A
COAD	chr1	182585963	Nonsense_Mutation	NA	E282*	0.27
COAD	chr1	182585661	Frame_Shift_Del	NA	*F383Sfs7**	0.23
COAD	chr1	182586631	Missense_Mutation	NA	G59D	0.29
COAD	chr1	182576343	Frame_Shift_Ins	NA	*R651Kfs11**	0.29	Ribonuc_2-5A
COAD	chr1	182576364	Frame_Shift_Ins	novel	*M644Nfs3**	0.26	Ribonuc_2-5A
COAD	chr1	182585472	Missense_Mutation	NA	L445F	0.1
COAD	chr1	182586766	Missense_Mutation	rs766296817	T14M	0.31
COAD	chr1	182576343	Frame_Shift_Ins	NA	*R651Kfs11**	0.33	Ribonuc_2-5A
COAD	chr1	182576365	Frame_Shift_Del	novel	M644*	0.22	Ribonuc_2-5A
COAD	chr1	182586469	Missense_Mutation	NA	S113C	0.21
COAD	chr1	182586502	Missense_Mutation	NA	A102V	0.14
COAD	chr1	182576364	Frame_Shift_Ins	novel	*M644Nfs3**	0.32	Ribonuc_2-5A
ESCA	chr1	182581341	Missense_Mutation	rs755669893	R597W	0.32	Ribonuc_2-5A
GBM	chr1	182586470	Missense_Mutation	novel	S113P	0.09
GBM	chr1	182586008	Missense_Mutation	novel	N267D	0.06
GBM	chr1	182585584	Missense_Mutation	novel	L408Q	0.04
GBM	chr1	182585979	Frame_Shift_Del	novel	*L277Cfs9**	0.04
HNSC	chr1	182586483	Silent	novel	L108L	0.38
HNSC	chr1	182582162	Missense_Mutation	novel	P555T	0.3
HNSC	chr1	182586525	Silent	rs768816440	T94T	0.45
HNSC	chr1	182586830	5'UTR	novel		0.44
HNSC	chr1	182586396	Silent	novel	K137K	0.6
HNSC	chr1	182586242	Missense_Mutation	novel	D189H	0.25
HNSC	chr1	182586344	Nonsense_Mutation	rs766020877	R155*	0.32
HNSC	chr1	182585792	Nonsense_Mutation	novel	Q339*	0.11
KIRC	chr1	182575428	Silent	NA	A730A	0.3
KIRC	chr1	182582209	Missense_Mutation	rs762441300	F539S	0.31
LGG	chr1	182575555	Missense_Mutation	NA	P688L	0.41	Ribonuc_2-5A
LGG	chr1	182585572	Missense_Mutation	NA	R412Q	0.07
LIHC	chr1	182585365	Missense_Mutation	rs200144732	Y481C	0.19
LUAD	chr1	182586305	Missense_Mutation	NA	G168W	0.26
LUAD	chr1	182575380	3'UTR	novel		0.06
LUAD	chr1	182585774	Frame_Shift_Del	NA	*A345Qfs3**	0.11
LUAD	chr1	182575274	3'UTR	novel		0.1
LUAD	chr1	182585609	Missense_Mutation	NA	R400S	0.24
LUAD	chr1	182576372	Missense_Mutation	NA	M641I	0.23	Ribonuc_2-5A
LUAD	chr1	182584123	Silent	NA	I508I	0.2
LUAD	chr1	182575207	3'UTR	novel		0.29
LUAD	chr1	182585373	Silent	novel	S478S	0.34
LUAD	chr1	182586835	5'UTR	novel		0.1
LUAD	chr1	182585647	Missense_Mutation	novel	Q387P	0.2
LUAD	chr1	182586502	Missense_Mutation	NA	A102V	0.19
LUSC	chr1	182581339	Silent	novel	R597R	0.3
LUSC	chr1	182582205	Missense_Mutation	novel	E540D	0.25
LUSC	chr1	182585724	Silent	novel	L361L	0.06
LUSC	chr1	182575393	Silent	NA	*742*	0.2
LUSC	chr1	182575280	3'UTR	novel		0.15
LUSC	chr1	182575296	3'UTR	novel		0.16
LUSC	chr1	182575415	Missense_Mutation	NA	G735W	0.3
LUSC	chr1	182582081	Missense_Mutation	novel	G582C	0.19
LUSC	chr1	182575343	3'UTR	novel		0.13
LUSC	chr1	182586804	Translation_Start_Site	novel	M1?	0.23
LUSC	chr1	182575349	3'UTR	novel		0.48
LUSC	chr1	182586306	Silent	novel	G167G	0.09
LUSC	chr1	182585495	Nonsense_Mutation	NA	E438*	0.46
LUSC	chr1	182586501	Silent	rs200161417	A102A	0.25
LUSC	chr1	182586318	Silent	novel	R163R	0.42
LUSC	chr1	182575546	Missense_Mutation	NA	Y691C	0.42	Ribonuc_2-5A
LUSC	chr1	182586437	Missense_Mutation	novel	Y124H	0.5
LUSC	chr1	182585949	Missense_Mutation	novel	K286N	0.12
OV	chr1	182586143	Missense_Mutation	NA	T222S	0.46
OV	chr1	182582161	Missense_Mutation	novel	P555Q	0.06
OV	chr1	182576389	Missense_Mutation	novel	I636V	0.09	Ribonuc_2-5A
OV	chr1	182576268	Missense_Mutation	NA	E676G	0.26	Ribonuc_2-5A
OV	chr1	182575559	Missense_Mutation	NA	D687N	0.44	Ribonuc_2-5A
OV	chr1	182576317	Missense_Mutation	NA	G660C	0.37	Ribonuc_2-5A
OV	chr1	182582143	In_Frame_Ins	novel	D561delinsGCLLLLSEAGH	0.03
PAAD	chr1	182586021	Missense_Mutation	novel	E262D	0.09
PRAD	chr1	182581354	Silent	NA	R592R	0.2
PRAD	chr1	182586141	Silent	rs141997272	T222T	0.4
PRAD	chr1	182586461	Missense_Mutation	novel	A116T	0.38
READ	chr1	182584110	Missense_Mutation	novel	D513N	0.04
READ	chr1	182576358	Missense_Mutation	NA	K646T	0.2	Ribonuc_2-5A
READ	chr1	182576387	Missense_Mutation	NA	I636M	0.31	Ribonuc_2-5A
SARC	chr1	182586569	Missense_Mutation	novel	R80C	0.14
SARC	chr1	182575530	Silent	novel	F696F	0.19
SARC	chr1	182579989	Intron	novel		0.22
SKCM	chr1	182586709	Missense_Mutation	NA	V33A	0.44
SKCM	chr1	182586399	Silent	rs757657442	G136G	0.42
SKCM	chr1	182585897	Missense_Mutation	novel	L304F	0.37
SKCM	chr1	182586378	Silent	NA	F143F	0.24
SKCM	chr1	182586755	Missense_Mutation	NA	G18S	0.11
SKCM	chr1	182575470	Silent	rs763696156	F716F	0.22
SKCM	chr1	182586088	Missense_Mutation	NA	K240T	0.15
SKCM	chr1	182581288	Silent	NA	I614I	0.46
SKCM	chr1	182582124	Silent	NA	F567F	0.38
SKCM	chr1	182586519	Silent	novel	F96F	0.55
SKCM	chr1	182582199	Silent	NA	L542L	0.47
SKCM	chr1	182586474	Silent	NA	F111F	0.53
SKCM	chr1	182581285	Silent	rs749257214	L615L	0.38
SKCM	chr1	182585943	Silent	NA	I288I	0.38
SKCM	chr1	182586844	5'UTR	novel		0.71
SKCM	chr1	182585427	Missense_Mutation	NA	F460L	0.15
SKCM	chr1	182586424	Missense_Mutation	NA	A128V	0.64
SKCM	chr1	182586781	Missense_Mutation	NA	P9L	0.33
SKCM	chr1	182585428	Missense_Mutation	NA	F460S	0.07
SKCM	chr1	182586091	Missense_Mutation	novel	G239E	0.34
SKCM	chr1	182586092	Missense_Mutation	novel	G239R	0.33
SKCM	chr1	182586246	Silent	NA	L187L	0.29
SKCM	chr1	182582132	Missense_Mutation	rs200397730	R565C	0.26
SKCM	chr1	182575414	Missense_Mutation	NA	G735E	0.25
SKCM	chr1	182582174	Missense_Mutation	NA	V551I	0.13
SKCM	chr1	182582132	Missense_Mutation	rs200397730	R565C	0.42
SKCM	chr1	182586474	Silent	NA	F111F	0.39
STAD	chr1	182586525	Silent	rs768816440	T94T	0.17
STAD	chr1	182585721	Missense_Mutation	novel	K362N	0.24
STAD	chr1	182586702	Silent	rs780021840	N35N	0.25
STAD	chr1	182586284	Missense_Mutation	NA	A175T	0.16
STAD	chr1	182581336	Silent	rs775665408	N598N	0.08
STAD	chr1	182585980	Missense_Mutation	NA	A276E	0.15
STAD	chr1	182586069	Silent	NA	A246A	0.2
STAD	chr1	182586137	Silent	NA	L224L	0.17
STAD	chr1	182581343	Missense_Mutation	NA	L596R	0.04	Ribonuc_2-5A
STAD	chr1	182575565	Frame_Shift_Del	novel	*I685Lfs16**	0.32	Ribonuc_2-5A
STAD	chr1	182581276	Silent	rs572503904	L618L	0.24
UCEC	chr1	182585608	Missense_Mutation	NA	R400H	0.51
UCEC	chr1	182585879	Missense_Mutation	rs747178598	R310W	0.18
UCEC	chr1	182576371	Missense_Mutation	NA	K642E	0.32	Ribonuc_2-5A
UCEC	chr1	182579733	Intron	novel		0.24
UCEC	chr1	182575172	3'UTR	novel		0.25
UCEC	chr1	182576376	Missense_Mutation	novel	V640A	0.29	Ribonuc_2-5A
UCEC	chr1	182575254	3'UTR	novel		0.5
UCEC	chr1	182575349	3'UTR	novel		0.34
UCEC	chr1	182579924	Intron	novel		0.39
UCEC	chr1	182579980	Intron	novel		0.39
UCEC	chr1	182585981	Missense_Mutation	novel	A276T	0.27
UCEC	chr1	182576358	Missense_Mutation	NA	K646T	0.24	Ribonuc_2-5A
UCEC	chr1	182586141	Silent	rs141997272	T222T	0.06
UCEC	chr1	182585354	Missense_Mutation	NA	D485Y	0.15
UCEC	chr1	182586512	Missense_Mutation	NA	A99T	0.15
UCEC	chr1	182586853	5'UTR	novel		0.14
UCEC	chr1	182584091	Missense_Mutation	NA	R519K	0.34
UCEC	chr1	182586449	Nonsense_Mutation	novel	E120*	0.49
UCEC	chr1	182585582	Nonsense_Mutation	NA	Q409*	0.25
UCEC	chr1	182586103	Frame_Shift_Ins	novel	*R235Mfs33**	0.13
UCEC	chr1	182582184	Silent	novel	N547N	0.27
UCEC	chr1	182586669	Missense_Mutation	novel	E46D	0.33
UCEC	chr1	182586266	Missense_Mutation	rs779087511	V181I	0.33
UCEC	chr1	182575487	Nonsense_Mutation	novel	E711*	0.32	Ribonuc_2-5A
UCEC	chr1	182575213	3'UTR	novel		0.73
UCEC	chr1	182585924	Missense_Mutation	novel	R295C	0.39
UCEC	chr1	182585943	Silent	NA	I288I	0.39
UCEC	chr1	182576358	Missense_Mutation	NA	K646T	0.36	Ribonuc_2-5A
UCEC	chr1	182579787	Intron	novel		0.24
UCEC	chr1	182581248	Missense_Mutation	novel	S628R	0.37	Ribonuc_2-5A
UCEC	chr1	182581351	Silent	novel	Y593Y	0.38
UCEC	chr1	182586404	Missense_Mutation	novel	Y135H	0.27
UCEC	chr1	182585364	Silent	NA	Y481Y	0.25
UCEC	chr1	182575389	3'UTR	novel		0.44
UCEC	chr1	182586012	Silent	novel	E265E	0.39
UCEC	chr1	182585528	Missense_Mutation	novel	R427G	0.25
UCEC	chr1	182586611	Missense_Mutation	rs745739936	A66T	0.27
UCEC	chr1	182585415	Silent	rs757258805	V464V	0.44
UCEC	chr1	182585478	Silent	rs777270662	A443A	0.34
UCEC	chr1	182586525	Silent	rs768816440	T94T	0.21
UCEC	chr1	182586523	Missense_Mutation	novel	P95H	0.19
UCEC	chr1	182581345	Silent	rs748847842	T595T	0.46
UCEC	chr1	182586039	Silent	novel	Q256Q	0.38
UCEC	chr1	182586155	Missense_Mutation	NA	V218M	0.27
UCEC	chr1	182585328	Splice_Region	NA	I493I	0.18
UCEC	chr1	182575494	Silent	novel	Q708Q	0.43
UCEC	chr1	182581330	Silent	novel	G600G	0.61
UCEC	chr1	182586343	Missense_Mutation	NA	R155Q	0.24
UCEC	chr1	182585788	Missense_Mutation	NA	S340N	0.35
UCEC	chr1	182586836	5'UTR	novel		0.14
UCEC	chr1	182575156	3'UTR	novel		0.2
UCEC	chr1	182586464	Missense_Mutation	novel	G115R	0.24
UCEC	chr1	182575476	Silent	novel	K714K	0.27
UCEC	chr1	182576364	Frame_Shift_Ins	novel	*M644Nfs3**	0.32	Ribonuc_2-5A
UCEC	chr1	182586650	Missense_Mutation	NA	F53L	0.14
UCEC	chr1	182586611	Missense_Mutation	rs745739936	A66T	0.3

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
DLBC	DEL	0.0417	0.0017831
KIRC	AMP	0.089	0.059566
PAAD	AMP	0.2283	0.085665
TGCT	AMP	0.3467	0.088103
THCA	AMP	0.0501	0.075436

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.0027	Kaplan-Meier Survival Analysis
SARC	0.0001	Kaplan-Meier Survival Analysis
MESO	0.005	Kaplan-Meier Survival Analysis
UCS	0.05	Kaplan-Meier Survival Analysis
SKCM	0.018	Kaplan-Meier Survival Analysis
LGG	0.0048	Kaplan-Meier Survival Analysis
OV	0.025	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBDs

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000135828 (Gene tree)
Gene ID: 6041
Gene Symbol: RNASEL
Alias: RNS4|PRCA1
Full Name: ribonuclease L
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 15,652 bases
Position: chr1:182,573,634-182,589,285
Accession: 10050
RBP type: canonical RBP
Summary: This gene encodes a component of the interferon-regulated 2-5A system that functions in the antiviral and antiproliferative roles of interferons. Mutations in this gene have been associated with predisposition to prostate cancer and this gene is a candidate for the hereditary prostate cancer 1 (HPC1) allele. [provided by RefSeq, Jul 2008]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000356530	Ribonuc_2-5A	PF06479.12	5.3e-26	1	1

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
15063798	Expression of interferon-inducible recombinant human RNase L causes RNA degradation and inhibition of cell growth in Escherichia coli.	Biochem Biophys Res Commun	2004 Apr 30	Pandey M	-
8463302	2',5'-Oligoadenylate-dependent RNase L is a dimer of regulatory and catalytic subunits.	J Biol Chem	1993 Apr 15	Salehzada T	-
16627618	The primary function of RNA binding by the influenza A virus NS1 protein in infected cells: Inhibiting the 2'-5' oligo (A) synthetase/RNase L pathway.	Proc Natl Acad Sci U S A	2006 May 2	Min JY	-
10926206	Characterization of RNABP, an RNA binding protein that associates with RNase L.	J Interferon Cytokine Res	2000 Jul	Le Roy F	-
19252527	RNase L downmodulation of the RNA-binding protein, HuR, and cellular growth.	Oncogene	2009 Apr 16	Al-Ahmadi W	doi: 10.1038/onc.2009.16
25301952	RNase L attenuates mitogen-stimulated gene expression via transcriptional and post-transcriptional mechanisms to limit the proliferative response.	J Biol Chem	2014 Nov 28	Brennan-Laun SE	doi: 10.1074/jbc.M114.589556
21813458	Nucleoside modifications in RNA limit activation of 2'-5'-oligoadenylate synthetase and increase resistance to cleavage by RNase L.	Nucleic Acids Res	2011 Nov	Anderson BR	doi: 10.1093/nar/gkr586
24659782	Transcription of angiogenin and ribonuclease 4 is regulated by RNA polymerase III elements and a CCCTC binding factor (CTCF)-dependent intragenic chromatin loop.	J Biol Chem	2014 May 2	Sheng J	doi: 10.1074/jbc.M114.551762
3745989	The effect of ammonium ion on the induction of (2'-5')-(A)n synthetase and (2'-5')-(A)n-dependent endoribonuclease activities by interferon in mouse BALB/C 3T3 cells.	J Interferon Res	1986 Jun	Wu JM	-
3427064	Phosphorothioate analogues of 2',5'-oligoadenylate. Enzymatic synthesis, properties, and biological activities of 2',5'-phosphorothioates from adenosine 5'-O-(2-thiotriphosphate) and adenosine 5'-O-(3-thiotriphosphate).	Biochemistry	1987 Nov 3	Suhadolnik RJ	-
2422811	Inhibition of 2',5'-oligo(A)-dependent endoribonuclease by 2',5'-oligo(A) degradation products.	Virology	1986 Jun	Williams GJ	-
9268370	A bipartite model of 2-5A-dependent RNase L.	J Biol Chem	1997 Aug 29	Dong B	-
15206938	Contribution of Tyr712 and Phe716 to the activity of human RNase L.	Eur J Biochem	2004 Jul	Nakanishi M	-
18426919	A viral RNA competitively inhibits the antiviral endoribonuclease domain of RNase L.	RNA	2008 Jun	Townsend HL	doi: 10.1261/rna.958908
17145707	Selection and cloning of poly(rC)-binding protein 2 and Raf kinase inhibitor protein RNA activators of 2',5'-oligoadenylate synthetase from prostate cancer cells.	Nucleic Acids Res	2006	Molinaro RJ	-
16978086	Human telomerase RNA degradation by 2'-5'-linked oligoadenylate antisense chimeras in a cell-free system, cultured tumor cells, and murine xenograft models.	Oligonucleotides	2006 Fall	Paranjape JM	-
21190483	New insights into the role of RNase L in innate immunity.	J Interferon Cytokine Res	2011 Jan	Chakrabarti A	doi: 10.1089/jir.2010.0120
25275129	The 2'-5'-oligoadenylate synthetase 3 enzyme potently synthesizes the 2'-5'-oligoadenylates required for RNase L activation.	J Virol	2014 Dec	Ibsen MS	doi: 10.1128/JVI.01763-14
23608948	Mechanistic insights into RNase L through use of an MDMX-derived multi-functional protein domain.	Biochim Biophys Acta	2013 Aug	Garvie CW	doi: 10.1016/j.bbapap.2013.04.010
25871524	Characterization of the termini of the West Nile virus genome and their interactions with the small isoform of the 2' 5'-oligoadenylate synthetase family.	J Struct Biol	2015 May	Deo S	doi: 10.1016/j.jsb.2015.04.005
25752600	OASes and STING: adaptive evolution in concert.	Genome Biol Evol	2015 Mar 9	Mozzi A	doi: 10.1093/gbe/evv046.
30209174	Human Host Range Restriction of the Vaccinia Virus C7/K1 Double Deletion Mutant Is Mediated by an Atypical Mode of Translation Inhibition.	J Virol	2018 Nov 12	Sivan G	doi: 10.1128/JVI.01329-18
30587119	Origin and development of oligoadenylate synthetase immune system.	BMC Evol Biol	2018 Dec 27	Hu J	doi: 10.1186/s12862-018-1315-x.

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000539397	RNASEL-202	4046	-	ENSP00000440844	652 (aa)	-	Q05823
ENST00000367559	RNASEL-201	4238	-	ENSP00000356530	741 (aa)	-	Q05823

Gene Model

Click here to download ENSG00000135828's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa04621	NOD-like receptor signaling pathway	KEGG
hsa05160	Hepatitis C	KEGG
hsa05164	Influenza A	KEGG
hsa05168	Herpes simplex virus 1 infection	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000135828	Multiple Sclerosis	6E-9	23412934
ENSG00000135828	Circadian Rhythm	7E-28	27494321
ENSG00000135828	Circadian Rhythm	3E-12	27494321
ENSG00000135828	Circadian Rhythm	7E-18	26835600

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000135828	rs516134	1	182584558	C	Chronotype	27494321	[0.059-0.103] unit increase	0.081	EFO_0004354
ENSG00000135828	rs516134	1	182584558	C	Morning vs. evening chronotype	27494321	[1.15-1.27]	1.21	EFO_0004354
ENSG00000135828	rs12736689	1	182580594	C	Morning vs. evening chronotype	26835600		1.3513513	EFO_0004354
ENSG00000135828	rs533259	1	182579884	?	Multiple sclerosis	23412934			EFO_0003885

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000135828's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000135828	RNASEL	98	73.197	ENSAMEG00000007756	RNASEL	99	71.905	Ailuropoda_melanoleuca
ENSG00000135828	RNASEL	91	44.279	ENSAPLG00000009854	RNASEL	99	43.217	Anas_platyrhynchos
ENSG00000135828	RNASEL	94	45.920	ENSACAG00000004961	RNASEL	97	44.167	Anolis_carolinensis
ENSG00000135828	RNASEL	100	87.584	ENSANAG00000036044	RNASEL	100	87.584	Aotus_nancymaae
ENSG00000135828	RNASEL	98	71.787	ENSBTAG00000009091	RNASEL	99	71.547	Bos_taurus
ENSG00000135828	RNASEL	100	86.119	ENSCJAG00000004725	RNASEL	100	86.119	Callithrix_jacchus
ENSG00000135828	RNASEL	98	71.473	ENSCAFG00000013121	RNASEL	99	71.409	Canis_familiaris
ENSG00000135828	RNASEL	98	71.547	ENSCAFG00020014858	RNASEL	100	71.324	Canis_lupus_dingo
ENSG00000135828	RNASEL	98	70.822	ENSCHIG00000021530	RNASEL	99	70.822	Capra_hircus
ENSG00000135828	RNASEL	100	74.832	ENSTSYG00000000281	RNASEL	100	74.832	Carlito_syrichta
ENSG00000135828	RNASEL	100	87.736	ENSCCAG00000032500	RNASEL	100	87.736	Cebus_capucinus
ENSG00000135828	RNASEL	100	92.848	ENSCATG00000038808	RNASEL	100	92.848	Cercocebus_atys
ENSG00000135828	RNASEL	100	67.251	ENSCLAG00000011944	RNASEL	100	67.251	Chinchilla_lanigera
ENSG00000135828	RNASEL	100	92.982	ENSCSAG00000012514	RNASEL	100	92.982	Chlorocebus_sabaeus
ENSG00000135828	RNASEL	98	46.201	ENSCPBG00000015776	-	99	46.101	Chrysemys_picta_bellii
ENSG00000135828	RNASEL	98	93.526	ENSCANG00000041251	RNASEL	100	93.526	Colobus_angolensis_palliatus
ENSG00000135828	RNASEL	98	64.789	ENSCGRG00001008939	Rnasel	99	64.247	Cricetulus_griseus_chok1gshd
ENSG00000135828	RNASEL	98	64.789	ENSCGRG00000009259	Rnasel	99	64.247	Cricetulus_griseus_crigri
ENSG00000135828	RNASEL	98	71.698	ENSDNOG00000017705	RNASEL	99	71.331	Dasypus_novemcinctus
ENSG00000135828	RNASEL	94	67.770	ENSDORG00000005886	Rnasel	99	67.770	Dipodomys_ordii
ENSG00000135828	RNASEL	90	67.836	ENSETEG00000008370	RNASEL	82	67.836	Echinops_telfairi
ENSG00000135828	RNASEL	99	75.311	ENSEASG00005006600	RNASEL	99	76.976	Equus_asinus_asinus
ENSG00000135828	RNASEL	99	75.466	ENSECAG00000015188	RNASEL	99	77.254	Equus_caballus
ENSG00000135828	RNASEL	98	59.341	ENSEEUG00000011471	RNASEL	100	58.480	Erinaceus_europaeus
ENSG00000135828	RNASEL	98	75.000	ENSFCAG00000024554	RNASEL	100	74.207	Felis_catus
ENSG00000135828	RNASEL	94	42.834	ENSFALG00000008002	RNASEL	97	41.702	Ficedula_albicollis
ENSG00000135828	RNASEL	85	65.583	ENSFDAG00000016599	RNASEL	100	65.583	Fukomys_damarensis
ENSG00000135828	RNASEL	91	43.163	ENSGALG00000042986	RNASEL	97	41.931	Gallus_gallus
ENSG00000135828	RNASEL	100	98.516	ENSGGOG00000023414	RNASEL	100	98.516	Gorilla_gorilla
ENSG00000135828	RNASEL	98	67.969	ENSHGLG00100009841	RNASEL	99	68.824	Heterocephalus_glaber_male
ENSG00000135828	RNASEL	99	73.378	ENSSTOG00000007352	RNASEL	99	73.378	Ictidomys_tridecemlineatus
ENSG00000135828	RNASEL	98	63.043	ENSJJAG00000013606	Rnasel	98	56.667	Jaculus_jaculus
ENSG00000135828	RNASEL	95	42.897	ENSLACG00000000804	RNASEL	99	42.897	Latimeria_chalumnae
ENSG00000135828	RNASEL	99	68.054	ENSLAFG00000022307	RNASEL	99	68.054	Loxodonta_africana
ENSG00000135828	RNASEL	100	92.173	ENSMFAG00000044965	RNASEL	100	92.173	Macaca_fascicularis
ENSG00000135828	RNASEL	100	92.308	ENSMNEG00000032732	RNASEL	100	92.308	Macaca_nemestrina
ENSG00000135828	RNASEL	100	92.713	ENSMLEG00000037368	RNASEL	100	92.713	Mandrillus_leucophaeus
ENSG00000135828	RNASEL	98	39.918	ENSMGAG00000003316	RNASEL	99	39.918	Meleagris_gallopavo
ENSG00000135828	RNASEL	98	63.380	ENSMAUG00000020643	Rnasel	98	64.078	Mesocricetus_auratus
ENSG00000135828	RNASEL	99	77.328	ENSMICG00000026907	RNASEL	99	77.328	Microcebus_murinus
ENSG00000135828	RNASEL	97	64.771	ENSMOCG00000009828	Rnasel	98	64.771	Microtus_ochrogaster
ENSG00000135828	RNASEL	97	55.230	ENSMODG00000006829	RNASEL	94	55.230	Monodelphis_domestica
ENSG00000135828	RNASEL	98	65.247	MGP_CAROLIEiJ_G0014713	Rnasel	97	68.636	Mus_caroli
ENSG00000135828	RNASEL	99	64.276	ENSMUSG00000066800	Rnasel	99	66.667	Mus_musculus
ENSG00000135828	RNASEL	99	63.488	MGP_PahariEiJ_G0027949	Rnasel	99	64.201	Mus_pahari
ENSG00000135828	RNASEL	98	63.793	MGP_SPRETEiJ_G0015520	Rnasel	99	64.763	Mus_spretus
ENSG00000135828	RNASEL	100	69.372	ENSMPUG00000011522	RNASEL	99	69.793	Mustela_putorius_furo
ENSG00000135828	RNASEL	100	71.640	ENSMLUG00000010098	RNASEL	100	71.640	Myotis_lucifugus
ENSG00000135828	RNASEL	100	95.007	ENSNLEG00000018010	RNASEL	100	95.007	Nomascus_leucogenys
ENSG00000135828	RNASEL	100	65.903	ENSODEG00000002238	RNASEL	100	65.903	Octodon_degus
ENSG00000135828	RNASEL	95	55.099	ENSOANG00000000982	RNASEL	100	55.099	Ornithorhynchus_anatinus
ENSG00000135828	RNASEL	99	59.134	ENSOCUG00000015922	RNASEL	100	59.134	Oryctolagus_cuniculus
ENSG00000135828	RNASEL	100	78.437	ENSOGAG00000002612	RNASEL	100	78.437	Otolemur_garnettii
ENSG00000135828	RNASEL	100	71.795	ENSOARG00000018978	RNASEL	100	71.795	Ovis_aries
ENSG00000135828	RNASEL	100	97.436	ENSPPAG00000029542	RNASEL	100	97.436	Pan_paniscus
ENSG00000135828	RNASEL	98	75.314	ENSPPRG00000003895	RNASEL	100	74.621	Panthera_pardus
ENSG00000135828	RNASEL	98	73.585	ENSPTIG00000017036	RNASEL	100	73.103	Panthera_tigris_altaica
ENSG00000135828	RNASEL	100	97.301	ENSPTRG00000001755	RNASEL	100	97.301	Pan_troglodytes
ENSG00000135828	RNASEL	100	92.713	ENSPANG00000016769	RNASEL	100	92.713	Papio_anubis
ENSG00000135828	RNASEL	97	43.876	ENSPSIG00000008045	-	99	44.061	Pelodiscus_sinensis
ENSG00000135828	RNASEL	96	49.373	ENSPSIG00000007735	-	99	48.352	Pelodiscus_sinensis
ENSG00000135828	RNASEL	99	65.438	ENSPEMG00000012855	Rnasel	98	67.036	Peromyscus_maniculatus_bairdii
ENSG00000135828	RNASEL	98	55.329	ENSPCIG00000018112	RNASEL	99	55.895	Phascolarctos_cinereus
ENSG00000135828	RNASEL	100	95.951	ENSPPYG00000000435	RNASEL	100	95.951	Pongo_abelii
ENSG00000135828	RNASEL	62	65.352	ENSPCAG00000015612	-	62	65.634	Procavia_capensis
ENSG00000135828	RNASEL	100	80.162	ENSPCOG00000013879	RNASEL	100	80.162	Propithecus_coquereli
ENSG00000135828	RNASEL	99	71.644	ENSPVAG00000010445	RNASEL	99	71.644	Pteropus_vampyrus
ENSG00000135828	RNASEL	99	63.008	ENSRNOG00000027017	Rnasel	99	63.008	Rattus_norvegicus
ENSG00000135828	RNASEL	100	94.197	ENSRBIG00000044741	RNASEL	100	94.197	Rhinopithecus_bieti
ENSG00000135828	RNASEL	100	94.062	ENSRROG00000035978	RNASEL	100	94.062	Rhinopithecus_roxellana
ENSG00000135828	RNASEL	100	87.197	ENSSBOG00000034574	RNASEL	100	87.197	Saimiri_boliviensis_boliviensis
ENSG00000135828	RNASEL	98	71.698	ENSSSCG00000015549	RNASEL	99	70.755	Sus_scrofa
ENSG00000135828	RNASEL	85	75.472	ENSTBEG00000004013	RNASEL	85	75.472	Tupaia_belangeri
ENSG00000135828	RNASEL	99	69.147	ENSTTRG00000007635	RNASEL	100	69.147	Tursiops_truncatus
ENSG00000135828	RNASEL	98	73.824	ENSUMAG00000016510	RNASEL	99	72.323	Ursus_maritimus
ENSG00000135828	RNASEL	98	71.823	ENSVVUG00000008895	RNASEL	99	71.823	Vulpes_vulpes

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003723	RNA binding	7514601.	IDA	Function
GO:0004521	endoribonuclease activity	7514601.	NAS	Function
GO:0004672	protein kinase activity	-	IEA	Function
GO:0005515	protein binding	7539425.20875083.	IPI	Function
GO:0005524	ATP binding	-	IEA	Function
GO:0005575	cellular_component	-	ND	Component
GO:0005759	mitochondrial matrix	-	TAS	Component
GO:0005829	cytosol	-	TAS	Component
GO:0006364	rRNA processing	-	IEA	Process
GO:0006397	mRNA processing	-	IEA	Process
GO:0006468	protein phosphorylation	7514601.	NAS	Process
GO:0016363	nuclear matrix	-	IEA	Component
GO:0019843	rRNA binding	-	IEA	Function
GO:0043021	ribonucleoprotein complex binding	-	IEA	Function
GO:0043488	regulation of mRNA stability	-	IEA	Process
GO:0045071	negative regulation of viral genome replication	19923450.	IDA	Process
GO:0045444	fat cell differentiation	-	IEA	Process
GO:0045944	positive regulation of transcription by RNA polymerase II	19245366.	IDA	Process
GO:0046326	positive regulation of glucose import	-	IEA	Process
GO:0046872	metal ion binding	-	IEA	Function
GO:0051607	defense response to virus	19923450.	IDA	Process
GO:0051607	defense response to virus	-	TAS	Process
GO:0060337	type I interferon signaling pathway	-	TAS	Process
GO:0060338	regulation of type I interferon-mediated signaling pathway	-	TAS	Process
GO:0090502	RNA phosphodiester bond hydrolysis, endonucleolytic	-	IEA	Process

EuRBPDB

Note: to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBDs

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.