EuRBPDB

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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
20163912Annexin-1 protects MCF7 breast cancer cells against heat-induced growth arrest and DNA damage.Cancer Lett2010 Aug 1Nair Sdoi: 10.1016/j.canlet.2010.01.026
25344217Investigation of circulating antibodies to ANXA1 in breast cancer.Tumour Biol2015 FebHuang Ydoi: 10.1007/s13277-014-2751-x
25536365Annexin-A1 regulates microRNA-26b* and microRNA-562 to directly target NF-??B and angiogenesis in breast cancer cells.PLoS One2014 Dec 23Anbalagan Ddoi: 10.1371/journal.pone.0114507
16741918The impact of altered annexin I protein levels on apoptosis and signal transduction pathways in prostate cancer cells.Prostate2006 Sep 15Hsiang CH-
28212890Annexin A1 influences in breast cancer: Controversies on contributions to tumour, host and immunoediting processes.Pharmacol Res2017 MayTu Ydoi: 10.1016/j.phrs.2017.02.011
27105503ANXA1 inhibits miRNA-196a in a negative feedback loop through NF-kB and c-Myc to reduce breast cancer proliferation.Oncotarget2016 May 10Yuan Ydoi: 10.18632/oncotarget.8875.
29091952Evaluation of miRNA-196a2 and apoptosis-related target genes: ANXA1, DFFA and PDCD4 expression in gastrointestinal cancer patients: A pilot study.PLoS One2017 Nov 1Fawzy MSdoi: 10.1371/journal.pone.0187310
24156336Potential role of Anxa1 in cancer.Future Oncol2013 NovGuo Cdoi: 10.2217/fon.13.114.
26369530Cysteine-rich secretory protein 3 plays a role in prostate cancer cell invasion and affects expression of PSA and ANXA1.Mol Cell Biochem2016 JanPathak BRdoi: 10.1007/s11010-015-2564-2
26657294Annexin-A1 and caldesmon are associated with resistance to tamoxifen in estrogen receptor positive recurrent breast cancer.Oncotarget2016 Jan 19De Marchi Tdoi: 10.18632/oncotarget.6521.
14733945Annexin-I expression modulates drug resistance in tumor cells.Biochem Biophys Res Commun2004 Feb 6Wang Y-
23786757Low Annexin A1 expression predicts benefit from induction chemotherapy in oral cancer patients with moderate or poor pathologic differentiation grade.BMC Cancer2013 Jun 21Zhu DWdoi: 10.1186/1471-2407-13-301.
15447985Comprehensive characterization of annexin I alterations in esophageal squamous cell carcinoma.Clin Cancer Res2004 Sep 15Hu N-
20930115Annexin-1 signals mitogen-stimulated breast tumor cell proliferation by activation of the formyl peptide receptors (FPRs) 1 and 2.FASEB J2011 FebKhau Tdoi: 10.1096/fj.09-154096
20308542Annexin A1 regulates TGF-beta signaling and promotes metastasis formation of basal-like breast cancer cells.Proc Natl Acad Sci U S A2010 Apr 6de Graauw Mdoi: 10.1073/pnas.0913360107
25490767Inflammation and cancer: role of annexin A1 and FPR2/ALX in proliferation and metastasis in human laryngeal squamous cell carcinoma.PLoS One2014 Dec 9Gastardelo TSdoi: 10.1371/journal.pone.0111317
19351789Loss of annexin A1 disrupts normal prostate glandular structure by inducing autocrine IL-6 signaling.Carcinogenesis2009 JulInokuchi Jdoi: 10.1093/carcin/bgp078
25983101ANXA1 silencing increases the sensitivity of cancer cells to low-concentration arsenic trioxide treatment by inhibiting ERK MAPK activation.Tumori2015 Jul-AugZhang Xdoi: 10.5301/tj.5000315
24464914CAF-secreted annexin A1 induces prostate cancer cells to gain stem cell-like features.Mol Cancer Res2014 AprGeary LAdoi: 10.1158/1541-7786.MCR-13-0469
25592491Upregulated Annexin A1 promotes cellular invasion in triple-negative breast cancer.Oncol Rep2015 MarOkano Mdoi: 10.3892/or.2015.3720
20924191Annexin-1 downregulation is associated with clinical outcome in Chinese patients with hilar cholangiocarcinoma.Eur Surg Res2010Wang Ddoi: 10.1159/000320237
22929401Upregulation of Hsp90-beta and annexin A1 correlates with poor survival and lymphatic metastasis in lung cancer patients.J Exp Clin Cancer Res2012 Aug 28Biaoxue R-
20872967Up-regulation of hnRNP A1, Ezrin, tubulin β-2C and Annexin A1 in sentinel lymph nodes of colorectal cancer.World J Gastroenterol2010 Oct 7He ZY-
26137966Annexin A1 expression in a pooled breast cancer series: association with tumor subtypes and prognosis.BMC Med2015 Jul 2Sobral-Leite Mdoi: 10.1186/s12916-015-0392-6.
25510623Role of intracellular and extracellular annexin A1 in migration and invasion of human pancreatic carcinoma cells.BMC Cancer2014 Dec 16Belvedere Rdoi: 10.1186/1471-2407-14-961.
26000884Annexin A1 Preferentially Predicts Poor Prognosis of Basal-Like Breast Cancer Patients by Activating mTOR-S6 Signaling.PLoS One2015 May 22Bhardwaj Adoi: 10.1371/journal.pone.0127678
18663355MicroRNA-196a targets annexin A1: a microRNA-mediated mechanism of annexin A1 downregulation in cancers.Oncogene2008 Nov 6Luthra Rdoi: 10.1038/onc.2008.256
26312765Annexin A1 is involved in the acquisition and maintenance of a stem cell-like/aggressive phenotype in prostate cancer cells with acquired resistance to zoledronic acid.Oncotarget2015 Sep 22Bizzarro Vdoi: 10.18632/oncotarget.4725.
15944914Localization of annexins I, II, IV and VII in whole prostate sections from radical prostatectomy patients.Histol Histopathol2005 JulLehnigk Udoi: 10.14670/HH-20.673.
16627980Annexin-1 downregulation in thyroid cancer correlates to the degree of tumor differentiation.Cancer Biol Ther2006 JunPetrella A-
21127395Increased expression of annexin A1 is correlated with K-ras mutation in colorectal cancer.Tohoku J Exp Med2010 DecSu N-
21383699Annexin-1 interacts with NEMO and RIP1 to constitutively activate IKK complex and NF-??B: implication in breast cancer metastasis.Oncogene2011 Jul 14Bist Pdoi: 10.1038/onc.2011.28
20353277Annexin A1 expression and its prognostic significance in human breast cancer.Neoplasma2010Wang LP-
19208747Annexin-1 regulates growth arrest induced by high levels of estrogen in MCF-7 breast cancer cells.Mol Cancer Res2009 FebAng EZdoi: 10.1158/1541-7786.MCR-08-0147
26760764Annexin A1 sustains tumor metabolism and cellular proliferation upon stable loss of HIF1A.Oncotarget2016 Feb 9Rohwer Ndoi: 10.18632/oncotarget.6793.
20821804Annexin A1 attenuates EMT and metastatic potential in breast cancer.EMBO Mol Med2010 OctMaschler Sdoi: 10.1002/emmm.201000095.
26687139Study of the Annexin A1 and Its Associations with Carcinoembryonic Antigen and Mismatch Repair Proteins in Colorectal Cancer.J Gastrointest Cancer2016 MarYdy LRdoi: 10.1007/s12029-015-9791-3.
27840982Annexin A1 is involved in resistance to 5-FU in colon cancer cells.Oncol Rep2017 JanOnozawa Hdoi: 10.3892/or.2016.5234
25300907Co-overexpression of Hsp90-β and annexin A1 with a significantly positive correlation contributes to the diagnosis of lung cancer.Expert Rev Mol Diagn2014 NovBiaoxue Rdoi: 10.1586/14737159.2014.960517
17340616Annexin 1: differential expression in tumor and mast cells in human larynx cancer.Int J Cancer2007 Jun 15Silistino-Souza R-
26072160ANXA1Ac peptide reduces ID1 expression in cervical carcinoma cultures.Gene2015 Oct 10Prates Jdoi: 10.1016/j.gene.2015.06.021
25038797Differential expression of ANXA1 in benign human gastrointestinal tissues and cancers.BMC Cancer2014 Jul 19Gao Ydoi: 10.1186/1471-2407-14-520.
25337195Correlation of ANXA1 expression with drug resistance and relapse in bladder cancer.Int J Clin Exp Pathol2014 Aug 15Yu S-
25028131Dynamic dialog between cytokeratin 18 and annexin A1 in breast cancer: a transcriptional disequilibrium.Acta Histochem2014 SepAraujo TGdoi: 10.1016/j.acthis.2014.06.008
26135980Brain microvascular endothelium induced-annexin A1 secretion contributes to small cell lung cancer brain metastasis.Int J Biochem Cell Biol2015 SepLiu Ydoi: 10.1016/j.biocel.2015.06.019
22640735The role of annexin A1 in expression of matrix metalloproteinase-9 and invasion of breast cancer cells.Biochem Biophys Res Commun2012 Jun 22Kang Hdoi: 10.1016/j.bbrc.2012.05.114
16949910Decreased expression of annexin A1 is correlated with breast cancer development and progression as determined by a tissue microarray analysis.Hum Pathol2006 DecShen D-
17019707Annexin-I as a potential target for green tea extract induced actin remodeling.Int J Cancer2007 Jan 1Xiao GS-
18794547Occurrence of autoantibodies to annexin I, 14-3-3 theta and LAMR1 in prediagnostic lung cancer sera.J Clin Oncol2008 Nov 1Qiu Jdoi: 10.1200/JCO.2008.16.2388
23431236Expression of annexin-A1 and galectin-1 anti-inflammatory proteins and mRNA in chronic gastritis and gastric cancer.Mediators Inflamm2013Jorge YCdoi: 10.1155/2013/152860
24810927Overexpression of ANXA1 confers independent negative prognostic impact in rectal cancers receiving concurrent chemoradiotherapy.Tumour Biol2014 AugSheu MJdoi: 10.1007/s13277-014-2032-8
28009433Increased level of annexin A1 in bronchoalveolar lavage fluid as a potential diagnostic indicator for lung cancer.Int J Biol Markers2017 Mar 2Biaoxue Rdoi: 10.5301/jbm.5000243.
27834582Hypoxia regulates ANXA1 expression to support prostate cancer cell invasion and aggressiveness.Cell Adh Migr2017 May 4Bizzarro Vdoi: 10.1080/19336918.2016.1259056
29021293PPARγ Ligand-induced Annexin A1 Expression Determines Chemotherapy Response via Deubiquitination of Death Domain Kinase RIP in Triple-negative Breast Cancers.Mol Cancer Ther2017 NovChen Ldoi: 10.1158/1535-7163.MCT-16-0739
29986379miR-196a Is Able to Restore the Aggressive Phenotype of Annexin A1 Knock-Out in Pancreatic Cancer Cells by CRISPR/Cas9 Genome Editing.Int J Mol Sci2018 Jul 6Belvedere Rdoi: 10.3390/ijms19071967.
29932988Inhibition of the AnxA1/FPR1 autocrine axis reduces MDA-MB-231 breast cancer cell growth and aggressiveness in vitro and in vivo.Biochim Biophys Acta Mol Cell Res2018 SepVecchi Ldoi: 10.1016/j.bbamcr.2018.06.010
30518142Annexin A1 May Induce Pancreatic Cancer Progression as a Key Player of Extracellular Vesicles Effects as Evidenced in the In Vitro MIA PaCa-2 Model System.Int J Mol Sci2018 Dec 4Pessolano Edoi: 10.3390/ijms19123878.

Differential Expression

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
BLCAchr973158758Missense_MutationnovelP44S0.23
BLCAchr973160860Nonsense_Mutationrs756648223E148*0.41
BLCAchr973169107Missense_MutationnovelA313T0.46
BLCAchr973158722Missense_MutationnovelP32A0.19
BLCAchr973159371Frame_Shift_InsnovelR77Afs*230.04
BLCAchr973162823Missense_MutationNAS173P0.8
BRCAchr973158572Missense_MutationNAF13L0.19
BRCAchr973158408Intronnovel0.2
BRCAchr973158708Missense_MutationNAS27L0.15
BRCAchr973163483Missense_MutationNAR188Q0.26
BRCAchr973160846Missense_MutationNAS143L0.37
BRCAchr973163518Missense_MutationnovelD200N0.15
CESCchr973158328Intronnovel0.53
CESCchr973158754Silentrs755464124F42F0.21
CESCchr973168842IntronNA0.45
COADchr973162841Missense_Mutationrs533499971A179T0.29
COADchr973169060Missense_MutationnovelI297T0.08
COADchr973169071Missense_MutationNAV301I0.34
COADchr973158766Silentrs148187721S46S0.29
COADchr973163524Missense_MutationnovelD202N0.46
COADchr973166191Splice_Regionrs757586479I267I0.14
COADchr973167525Missense_MutationNAF277L0.32
COADchr973169051Missense_MutationNAK294R0.12
ESCAchr973158353Intronnovel0.29
GBMchr973159402SilentnovelA83A0.19
GBMchr973158717Missense_MutationnovelG30A0.09
GBMchr9731701833'UTRnovel0.18
GBMchr973160296Missense_MutationnovelG102C0.13
HNSCchr973160812Missense_Mutationrs543730068T132A0.16
HNSCchr973160356Nonsense_MutationNAE122*0.11
KIRCchr973169078Missense_Mutationrs776755767R303H0.25
KIRPchr9731701573'UTRnovel0.49
LGGchr973158695Nonsense_MutationNAQ23*0.19
LIHCchr973167510SilentNAT272T0.08
LIHCchr973162785Missense_MutationnovelL160P0.08
LUADchr973158399Intronnovel0.23
LUADchr973162815Nonsense_MutationnovelS170*0.15
LUADchr973163490SilentNAE190E0.19
LUSCchr973167532Nonsense_MutationNAE280*0.49
OVchr973158773In_Frame_DelnovelA50_A54del0.04
OVchr973169054Missense_MutationnovelA295V0.06
OVchr973160842Missense_MutationnovelA142S0.06
PAADchr973160831Missense_MutationnovelI138S0.24
PAADchr973160303Missense_MutationnovelL104P0.17
PAADchr973160822Missense_MutationnovelD135V0.18
READchr973162805Missense_MutationNAD167Y0.25
READchr973160363Missense_Mutationrs752285742R124H0.36
READchr973158353Intronnovel0.27
READchr973158359Intronnovel0.57
READchr973160849Missense_MutationNAR144I0.13
READchr973163483Missense_MutationNAR188Q0.33
SARCchr973162766Intronnovel0.49
SARCchr973162769Splice_SitenovelX159_splice0.29
SARCchr973160345Missense_MutationnovelF118Y0.31
SARCchr973158732Missense_Mutationrs376171580A35V0.42
SKCMchr973170049Splice_SitenovelX329_splice0.18
SKCMchr973165138Missense_MutationnovelR212K0.38
SKCMchr973160860Missense_MutationNAE148K0.39
SKCMchr973159343Missense_MutationNAT64A0.13
SKCMchr973158759Missense_MutationNAP44L0.78
SKCMchr973158742SilentnovelP38P0.3
SKCMchr973169094Missense_Mutationrs751774481M308I0.26
SKCMchr973159333SilentnovelV60V0.43
SKCMchr973158584Missense_MutationNAE17K0.2
SKCMchr973166158SilentNAL256L0.36
SKCMchr973158747Missense_MutationnovelP40L0.81
STADchr973159367Nonsense_Mutationrs76459132R72*0.41
STADchr973163483Missense_MutationNAR188Q0.34
STADchr973166192Missense_MutationnovelV268M0.51
STADchr973167534Missense_MutationnovelE280D0.32
STADchr973169093Missense_Mutationrs766591114M308T0.23
STADchr973166189Missense_MutationNAI267V0.12
UCECchr973160363Missense_Mutationrs752285742R124H0.27
UCECchr973154326IntronNA0.29
UCECchr973160821Missense_MutationnovelD135Y0.12
UCECchr973165209Missense_MutationnovelV236L0.21
UCECchr973158773Missense_Mutationrs142511024A49T0.39
UCECchr973165154Silentrs370232910D217D0.41
UCECchr9731701723'UTRnovel0.49
UCECchr973158715Missense_MutationnovelK29N0.3
UCECchr973166192Missense_MutationnovelV268M0.28
UCECchr973165203Missense_Mutationrs138602190R234C0.26
UCECchr973158778SilentnovelA50A0.21
UCECchr973167547Missense_MutationnovelA285T0.47
UCECchr973167547Missense_MutationnovelA285T0.42
UCECchr973158353Intronnovel0.29
UCECchr973169129Missense_MutationnovelG320V0.34
UCECchr973158498Intronnovel0.4
UCECchr973167534Missense_MutationnovelE280D0.61
UCECchr973158353Intronnovel0.44
UCECchr973158392Intronnovel0.62
UCECchr973160882Missense_MutationnovelV155G0.07
UCECchr973160860Nonsense_Mutationrs756648223E148*0.41
UCECchr973163483Missense_MutationNAR188Q0.31
UCECchr973158353Intronnovel0.26
UCECchr9731702113'UTRnovel0.15
UCECchr973158415Intronrs5345415020.14
UCECchr973159368Missense_Mutationrs750091835R72Q0.26
UCECchr973166173Missense_MutationnovelE261D0.31
UCECchr973165161Missense_Mutationrs746783076V220M0.32
UCECchr973158782Missense_MutationnovelH52Y0.28
UCECchr973170070Missense_MutationnovelY335C0.33

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
CHOLDEL0.47220.067545
LAMLDEL0.02090.24147
PCPGDEL0.06790.13351
THCADEL0.04010.24038
THYMDEL0.01630.022012
UCECDEL0.20960.027215
UCSDEL0.58930.089783

Survival Analysis
CancerP-value Q-value
HNSC0.05

Kaplan-Meier Survival Analysis

SKCM0.0041

Kaplan-Meier Survival Analysis

BRCA0.038

Kaplan-Meier Survival Analysis

PAAD0.0022

Kaplan-Meier Survival Analysis

BLCA0.00011

Kaplan-Meier Survival Analysis

UCEC0.00017

Kaplan-Meier Survival Analysis

GBM0.025

Kaplan-Meier Survival Analysis

THCA0.00039

Kaplan-Meier Survival Analysis

LUAD0.036

Kaplan-Meier Survival Analysis

UVM0.0027

Kaplan-Meier Survival Analysis

Drugs

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Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBPome
  • Literatures
  • Expression
  • Transcripts
  • Gene Model
  • Phenotypes
  • PPI
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000135046 (Gene tree)
Gene ID
301
Gene Symbol
ANXA1
Alias
ANX1|LPC1
Full Name
annexin A1
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Plus strand
Length
18,663 bases
Position
chr9:73,151,731-73,170,393
Accession
533
RBP type
non-canonical RBP
Summary
This gene encodes a membrane-localized protein that binds phospholipids. This protein inhibits phospholipase A2 and has anti-inflammatory activity. Loss of function or expression of this gene has been detected in multiple tumors. [provided by RefSeq, Dec 2014]
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & HEK2932018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
29431736Capturing the interactome of newly transcribed RNANascentRICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
29431736Capturing the interactome of newly transcribed RNAPolyT-RICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
29431736Capturing the interactome of newly transcribed RNARIC & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
29431736Capturing the interactome of newly transcribed RNARICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & Hela2018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & MCF10A2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & U2OS2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
17068759Identification and analysis of altered alpha1,6-fucosylated glycoproteins associated with hepatocellular carcinoma metastasis.Proteomics2006 NovDai Z-
23575152Proteomic profiles of the embryonic chorioamnion and uterine caruncles in buffaloes (Bubalus bubalis) with normal and retarded embryonic development.Biol Reprod2013 May 16Balestrieri MLdoi: 10.1095/biolreprod.113.108696
12833515Proteome analysis of dermal fibroblasts cultured in vitro from human healthy subjects of different ages.Proteomics2003 JunBoraldi F-
16289138Differential regulation of anti-inflammatory proteins in human rheumatoid synoviocyte MH7A cell by celecoxib and ibuprofen.Life Sci2006 Apr 4Heum Park J-
28216224Targeted proteomics driven verification of biomarker candidates associated with breast cancer aggressiveness.Biochim Biophys Acta Proteins Proteom2017 MayProchazkova Idoi: 10.1016/j.bbapap.2017.02.012
8425544Structural characterization of a biologically active human lipocortin 1 expressed in Escherichia coli.Eur J Biochem1993 Jan 15Arcone R-
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000376911ANXA1-2022209XM_011518609ENSP00000366109346 (aa)XP_011516911P04083
ENST00000456643ANXA1-204799-ENSP00000412489204 (aa)-Q5T3N1
ENST00000468639ANXA1-205800--- (aa)--
ENST00000491192ANXA1-2071400--- (aa)--
ENST00000489109ANXA1-206749--- (aa)--
ENST00000257497ANXA1-2011509-ENSP00000257497346 (aa)-P04083
ENST00000415424ANXA1-203526-ENSP00000414013115 (aa)-Q5T3N0
ENST00000495713ANXA1-208905--- (aa)--
Gene Model
Click here to download ENSG00000135046's gene model file
Phenotypes
ensgIDTraitpValuePubmed ID
ENSG00000135046Body Mass Index1.7232818555814E-617903300
ENSG00000135046Cholesterol, HDL2.11273218885307E-617903299
ENSG00000135046Cholesterol, HDL2.02685186491581E-617903299
ENSG00000135046Cholesterol, HDL2.33158637451658E-617903299
ENSG00000135046Cholesterol, HDL1.2766215261944E-717903299
ENSG00000135046Cholesterol, HDL8.25313227839667E-717903299
ENSG00000135046Cholesterol, HDL2.3216857208194E-817903299
ENSG00000135046Cholesterol, HDL3.23563205075191E-917903299
ENSG00000135046Cholesterol, HDL6.79556539079082E-917903299
ENSG00000135046Cholesterol, HDL3.26320051665765E-817903299
ENSG00000135046Triglycerides3.64019904414124E-817903299
ENSG00000135046Triglycerides1.73376984008213E-1117903299
ENSG00000135046Lipids3.15036277519966E-817903299
ENSG00000135046Lipids1.57492227321464E-717903299
ENSG00000135046Lipids3.44806664445765E-917903299
ENSG00000135046Lipids8.23155770947624E-1017903299
ENSG00000135046Lipids2.85499867333783E-617903299
ENSG00000135046Cholesterol, LDL8.31863364883636E-817903299
ENSG00000135046Cholesterol, HDL4.27101252115517E-917903299
ENSG00000135046Cholesterol, HDL8.80351605880346E-917903299
ENSG00000135046Cholesterol, HDL2.6806283691468E-617903299
ENSG00000135046Cholesterol, HDL2.41014215550023E-617903299
ENSG00000135046Cholesterol, HDL1.33329395736561E-817903299
ENSG00000135046Cholesterol, HDL3.79602099195375E-1017903299
ENSG00000135046Erythrocytes2.60033161274025E-917903294
ENSG00000135046Erythrocytes1.60425022309054E-2517903294
ENSG00000135046Erythrocytes2.93332328544587E-2417903294
ENSG00000135046Erythrocytes9.80334399024299E-1117903294
ENSG00000135046Erythrocytes5.68867450892983E-817903294
ENSG00000135046Erythrocytes2.60033161274025E-917903294
ENSG00000135046Erythrocytes1.60425022309054E-2517903294
ENSG00000135046Erythrocytes2.93332328544587E-2417903294
ENSG00000135046Erythrocytes9.80334399024299E-1117903294
ENSG00000135046Erythrocytes5.68867450892983E-817903294
ENSG00000135046Erythrocytes1.15020446556271E-717903294
ENSG00000135046Erythrocytes3.60102759012696E-717903294
ENSG00000135046Erythrocytes1.75165662898972E-717903294
ENSG00000135046Erythrocytes2.47184457426902E-817903294
ENSG00000135046Erythrocytes1.15020446556271E-717903294
ENSG00000135046Erythrocytes3.60102759012696E-717903294
ENSG00000135046Erythrocytes1.75165662898972E-717903294
ENSG00000135046Erythrocytes2.47184457426902E-817903294
ENSG00000135046Glomerular Filtration Rate1.99415871226391E-717903292
ENSG00000135046Creatinine1.09686320659737E-517903292
ENSG00000135046Blood Pressure6.70434675318878E-617903302
ENSG00000135046Blood Pressure5.28639200128474E-617903302
ENSG00000135046Blood Pressure1.60759736911502E-617903302
ENSG00000135046Blood Pressure1.09903720548538E-617903302
ENSG00000135046Blood Pressure1.43435751885841E-717903302
ENSG00000135046Blood Pressure1.30405796947662E-717903302
ENSG00000135046Blood Pressure1.34290144571165E-717903302
ENSG00000135046Blood Pressure4.90846980081263E-717903302
ENSG00000135046Blood Pressure5.93946858419407E-617903302
ENSG00000135046Blood Pressure3.52837612007411E-617903302
ENSG00000135046Blood Pressure3.53151037062616E-617903302
ENSG00000135046Pancreatic Neoplasms5.9190000E-00519648918
ENSG00000135046Heart Failure9.1874402E-004-
ENSG00000135046Transferrin8.484e-005-
ENSG00000135046Body Height3.5390000E-005-
ENSG00000135046Body Height5.9710000E-005-
ENSG00000135046Body Height2.6100000E-006-
ENSG00000135046Body Height6.1820000E-006-
ENSG00000135046Body Height8.5540000E-007-
ENSG00000135046Waist Circumference4.3040000E-006-
ENSG00000135046Waist Circumference4.5080000E-005-
ENSG00000135046Blood Glucose8.3850000E-006-
ENSG00000135046Urine9.6899558E-005-
ENSG00000135046Platelet Function Tests1.1594700E-005-
ENSG00000135046Child Development Disorders, Pervasive1.8625300E-005-
ENSG00000135046Child Development Disorders, Pervasive3.5264000E-005-
ENSG00000135046Child Development Disorders, Pervasive2.3804900E-005-
ENSG00000135046Autistic Disorder1.1657000E-005-
ENSG00000135046Cholesterol, HDL2.1840000E-005-
ENSG00000135046Cholesterol, HDL8.9590000E-006-
ENSG00000135046Alpha-Globulins3.3470000E-005-
ENSG00000135046Bronchodilator Agents4E-626634245
ENSG00000135046Lung Volume Measurements4E-626634245
ENSG00000135046Bronchodilator Agents3E-626634245
ENSG00000135046Lung Volume Measurements3E-626634245
ENSG00000135046HIV-17E-620041166
ENSG00000135046Bronchodilator Agents6E-726634245
ENSG00000135046Lung Volume Measurements6E-726634245
ENSG00000135046Bronchodilator Agents4E-626634245
ENSG00000135046Lung Volume Measurements4E-626634245
ENSG00000135046Bronchodilator Agents4E-626634245
ENSG00000135046Lung Volume Measurements4E-626634245
ENSG00000135046Bronchodilator Agents4E-626634245
ENSG00000135046Lung Volume Measurements4E-626634245
ENSG00000135046Carboplatin6E-621844884
ENSG00000135046Bronchodilator Agents4E-626634245
ENSG00000135046Lung Volume Measurements4E-626634245
ENSG00000135046Parkinson Disease1E-626227905
ENSG00000135046Asthma4E-625918132
ENSG00000135046Toluene 2,4-Diisocyanate4E-625918132
ENSG00000135046Bronchodilator Agents4E-626634245
ENSG00000135046Lung Volume Measurements4E-626634245
ENSG00000135046Bronchodilator Agents3E-626634245
ENSG00000135046Lung Volume Measurements3E-626634245
ENSG00000135046Chemokine CCL52E-623251661
ENSG00000135046Obesity4E-625811787
ENSG00000135046Uric Acid4E-625811787
ENSG00000135046Macular Degeneration3E-926691988
ENSG00000135046Wet Macular Degeneration3E-926691988
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000135046's network

* RBP PPI network refers to all genes directly bind to RBP
Orthologs identified by RBPome
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000135046ANXA110089.565ENSMUSG00000024659Anxa110087.572Mus_musculus
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0001533cornified envelope10908733.IDAComponent
GO:0001780neutrophil homeostasis21957127.IMPProcess
GO:0001891phagocytic cup-IEAComponent
GO:0002250adaptive immune response-IEAProcess
GO:0002548monocyte chemotaxis21873635.IBAProcess
GO:0002548monocyte chemotaxis15187149.IDAProcess
GO:0002685regulation of leukocyte migration21873635.IBAProcess
GO:0002685regulation of leukocyte migration-ISSProcess
GO:0003697single-stranded DNA binding21873635.IBAFunction
GO:0003727single-stranded RNA binding21873635.IBAFunction
GO:0005102signaling receptor binding10882119.TASFunction
GO:0005198structural molecule activity21873635.IBAFunction
GO:0005198structural molecule activity10908733.IDAFunction
GO:0005509calcium ion binding-ISSFunction
GO:0005515protein binding21383699.IPIFunction
GO:0005543phospholipid binding2967291.TASFunction
GO:0005544calcium-dependent phospholipid binding21873635.IBAFunction
GO:0005544calcium-dependent phospholipid binding2138016.IDAFunction
GO:0005576extracellular region-TASComponent
GO:0005615extracellular space22664934.23580065.HDAComponent
GO:0005615extracellular space21873635.IBAComponent
GO:0005615extracellular space17008549.19625660.25664854.IDAComponent
GO:0005634nucleus22056994.IDAComponent
GO:0005654nucleoplasm-IDAComponent
GO:0005737cytoplasm17008549.19625660.22056994.IDAComponent
GO:0005737cytoplasm16130169.TASComponent
GO:0005768endosome18767904.IDAComponent
GO:0005829cytosol-IDAComponent
GO:0005884actin filament22773844.IDAComponent
GO:0005886plasma membrane21873635.IBAComponent
GO:0005886plasma membrane-IDAComponent
GO:0005913cell-cell adherens junction25468996.HDAComponent
GO:0005925focal adhesion21423176.HDAComponent
GO:0006909phagocytosis21873635.IBAProcess
GO:0006909phagocytosis-ISSProcess
GO:0006954inflammatory response21873635.IBAProcess
GO:0006954inflammatory response-ISSProcess
GO:0007165signal transduction16130169.TASProcess
GO:0007166cell surface receptor signaling pathway21873635.IBAProcess
GO:0007186G protein-coupled receptor signaling pathway-TASProcess
GO:0007187G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger21873635.IBAProcess
GO:0007187G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger25664854.IDAProcess
GO:0007187G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger15187149.IMPProcess
GO:0008360regulation of cell shape21873635.IBAProcess
GO:0008360regulation of cell shape15187149.IDAProcess
GO:0009986cell surface22056994.IDAComponent
GO:0010165response to X-ray21873635.IBAProcess
GO:0014839myoblast migration involved in skeletal muscle regeneration21873635.IBAProcess
GO:0016323basolateral plasma membrane-IEAComponent
GO:0016324apical plasma membrane-ISSComponent
GO:0016328lateral plasma membrane-ISSComponent
GO:0018149peptide cross-linking10908733.IDAProcess
GO:0019221cytokine-mediated signaling pathway-TASProcess
GO:0019834phospholipase A2 inhibitor activity21873635.IBAFunction
GO:0019834phospholipase A2 inhibitor activity2936963.3013422.IDAFunction
GO:0019898extrinsic component of membrane17008549.IDAComponent
GO:0030073insulin secretion21873635.IBAProcess
GO:0030216keratinocyte differentiation21873635.IBAProcess
GO:0030216keratinocyte differentiation10908733.IDAProcess
GO:0030659cytoplasmic vesicle membrane-IEAComponent
GO:0030674protein binding, bridging21873635.IBAFunction
GO:0030674protein binding, bridging10908733.IDAFunction
GO:0030850prostate gland development21873635.IBAProcess
GO:0031018endocrine pancreas development21873635.IBAProcess
GO:0031232extrinsic component of external side of plasma membrane19625660.IDAComponent
GO:0031313extrinsic component of endosome membrane-ISSComponent
GO:0031340positive regulation of vesicle fusion21873635.IBAProcess
GO:0031340positive regulation of vesicle fusion2138016.IDAProcess
GO:0031394positive regulation of prostaglandin biosynthetic process21873635.IBAProcess
GO:0031514motile cilium-ISSComponent
GO:0031532actin cytoskeleton reorganization21873635.IBAProcess
GO:0031532actin cytoskeleton reorganization15187149.IDAProcess
GO:0031901early endosome membrane-ISSComponent
GO:0031966mitochondrial membrane-IEAComponent
GO:0031982vesicle19190083.HDAComponent
GO:0032355response to estradiol21873635.IBAProcess
GO:0032508DNA duplex unwinding21873635.IBAProcess
GO:0032652regulation of interleukin-1 production21873635.IBAProcess
GO:0032652regulation of interleukin-1 production-ISSProcess
GO:0032743positive regulation of interleukin-2 production21873635.IBAProcess
GO:0032743positive regulation of interleukin-2 production17008549.IDAProcess
GO:0032991protein-containing complex-IEAComponent
GO:0033031positive regulation of neutrophil apoptotic process21873635.IBAProcess
GO:0033676double-stranded DNA-dependent ATPase activity21873635.IBAFunction
GO:0035924cellular response to vascular endothelial growth factor stimulus21873635.IBAProcess
GO:0035924cellular response to vascular endothelial growth factor stimulus22773844.IDAProcess
GO:0042063gliogenesis21873635.IBAProcess
GO:0042102positive regulation of T cell proliferation21873635.IBAProcess
GO:0042102positive regulation of T cell proliferation17008549.IDAProcess
GO:0042127regulation of cell proliferation21873635.IBAProcess
GO:0042383sarcolemma-IEAComponent
GO:0042493response to drug21873635.IBAProcess
GO:0042629mast cell granule-IEAComponent
GO:0042803protein homodimerization activity21873635.IBAFunction
GO:0043066negative regulation of apoptotic process16130169.TASProcess
GO:0043434response to peptide hormone21873635.IBAProcess
GO:0044849estrous cycle21873635.IBAProcess
GO:0045087innate immune response-IEAProcess
GO:0045627positive regulation of T-helper 1 cell differentiation21873635.IBAProcess
GO:0045627positive regulation of T-helper 1 cell differentiation17008549.IDAProcess
GO:0045629negative regulation of T-helper 2 cell differentiation21873635.IBAProcess
GO:0045629negative regulation of T-helper 2 cell differentiation17008549.IDAProcess
GO:0045920negative regulation of exocytosis21873635.IBAProcess
GO:0045920negative regulation of exocytosis19625660.IMPProcess
GO:0046632alpha-beta T cell differentiation21873635.IBAProcess
GO:0046632alpha-beta T cell differentiation-ISSProcess
GO:0046883regulation of hormone secretion21873635.IBAProcess
GO:0046883regulation of hormone secretion19625660.IMPProcess
GO:0048306calcium-dependent protein binding21873635.IBAFunction
GO:0048306calcium-dependent protein binding15226301.IPIFunction
GO:0050482arachidonic acid secretion21873635.IBAProcess
GO:0050727regulation of inflammatory response21873635.IBAProcess
GO:0050727regulation of inflammatory response-ISSProcess
GO:0062023collagen-containing extracellular matrix25037231.28344315.28675934.HDAComponent
GO:0070062extracellular exosome19056867.19199708.21362503.23533145.HDAComponent
GO:0070062extracellular exosome25664854.IDAComponent
GO:0070301cellular response to hydrogen peroxide21873635.IBAProcess
GO:0070365hepatocyte differentiation21873635.IBAProcess
GO:0070459prolactin secretion21873635.IBAProcess
GO:0070555response to interleukin-121873635.IBAProcess
GO:0071385cellular response to glucocorticoid stimulus21873635.IBAProcess
GO:0071385cellular response to glucocorticoid stimulus2936963.IDAProcess
GO:0071621granulocyte chemotaxis21873635.IBAProcess
GO:0071621granulocyte chemotaxis15187149.IDAProcess
GO:0090050positive regulation of cell migration involved in sprouting angiogenesis21873635.IBAProcess
GO:0090050positive regulation of cell migration involved in sprouting angiogenesis22773844.IDAProcess
GO:0090303positive regulation of wound healing21873635.IBAProcess
GO:0090303positive regulation of wound healing25664854.IDAProcess
GO:0097060synaptic membrane-IEAComponent
GO:0097350neutrophil clearance21873635.IBAProcess
GO:0097350neutrophil clearance21957127.IMPProcess
GO:0098609cell-cell adhesion-IEAProcess
GO:0098641cadherin binding involved in cell-cell adhesion25468996.HDAFunction
GO:1900087positive regulation of G1/S transition of mitotic cell cycle21873635.IBAProcess
GO:1900138negative regulation of phospholipase A2 activity21873635.IBAProcess
GO:1990814DNA/DNA annealing activity21873635.IBAFunction
GO:2000483negative regulation of interleukin-8 secretion21873635.IBAProcess
GO:2000483negative regulation of interleukin-8 secretion22056994.IMPProcess
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