| 28729678 | Tumor LDH-A expression and serum LDH status are two metabolic predictors for triple negative breast cancer brain metastasis. | Sci Rep | 2017 Jul 20 | Dong T | doi: 10.1038/s41598-017-06378-7. |
| 24366912 | Lactate dehydrogenase A silencing in IDH mutant gliomas. | Neuro Oncol | 2014 May | Chesnelong C | doi: 10.1093/neuonc/not243 |
| 25983002 | Inhibition of LDHA suppresses tumor progression in prostate cancer. | Tumour Biol | 2015 Sep | Xian ZY | doi: 10.1007/s13277-015-3540-x |
| 25762632 | JQ1 suppresses tumor growth through downregulating LDHA in ovarian cancer. | Oncotarget | 2015 Mar 30 | Qiu H | - |
| 26902416 | The miR-34a-LDHA axis regulates glucose metabolism and tumor growth in breast cancer. | Sci Rep | 2016 Feb 23 | Xiao X | doi: 10.1038/srep21735. |
| 27622920 | Lactate dehydrogenase inhibitors can reverse inflammation induced changes in colon cancer cells. | Eur J Pharm Sci | 2017 Jan 1 | Manerba M | doi: 10.1016/j.ejps.2016.09.014 |
| 28461244 | miR-30a-5p suppresses breast tumor growth and metastasis through inhibition of LDHA-mediated Warburg effect. | Cancer Lett | 2017 Aug 1 | Li L | doi: 10.1016/j.canlet.2017.04.034 |
| 30618169 | p53/Lactate dehydrogenase A axis negatively regulates aerobic glycolysis and tumor progression in breast cancer expressing wild-type p53. | Cancer Sci | 2019 Mar | Zhou Y | doi: 10.1111/cas.13928 |
| 25791837 | Melanoma brain metastasis is independent of lactate dehydrogenase A expression. | Neuro Oncol | 2015 Oct | Sundstrm T | doi: 10.1093/neuonc/nov040 |
| 19276158 | LDH-A inhibition, a therapeutic strategy for treatment of hereditary leiomyomatosis and renal cell cancer. | Mol Cancer Ther | 2009 Mar | Xie H | doi: 10.1158/1535-7163.MCT-08-1049 |
| 16132575 | Lactate dehydrogenase 5 (LDH5) relates to up-regulated hypoxia inducible factor pathway and metastasis in colorectal cancer. | Clin Exp Metastasis | 2005 | Koukourakis MI | - |
| 22897481 | Knockdown of lactate dehydrogenase A suppresses tumor growth and metastasis of human hepatocellular carcinoma. | FEBS J | 2012 Oct | Sheng SL | doi: 10.1111/j.1742-4658.2012.08748.x |
| 27641098 | LDHA-Associated Lactic Acid Production Blunts Tumor Immunosurveillance by T and NK Cells. | Cell Metab | 2016 Nov 8 | Brand A | doi: 10.1016/j.cmet.2016.08.011 |
| 27374173 | miR-200b is a key regulator of tumor progression and metabolism targeting lactate dehydrogenase A in human malignant glioma. | Oncotarget | 2016 Jul 26 | Hu S | doi: 10.18632/oncotarget.10301. |
| 29360449 | miR-142-3p inhibits aerobic glycolysis and cell proliferation in hepatocellular carcinoma via targeting LDHA. | Biochem Biophys Res Commun | 2018 Feb 12 | Hua S | doi: 10.1016/j.bbrc.2018.01.112. |
| 27432288 | microRNA-199a-3p functions as tumor suppressor by regulating glucose metabolism in testicular germ cell tumors. | Mol Med Rep | 2016 Sep | Liu X | doi: 10.3892/mmr.2016.5472 |
| 18821170 | Differentiated expression of the lactate dehydrogenase subunit M in pleural fluids of neoplastic aetiology. | Scand J Clin Lab Invest | 2009 | Kotyza J | doi: 10.1080/00365510802406626. |
| 27710971 | Prognostic Role of Lactate Dehydrogenase Expression in Urologic Cancers: A Systematic Review and Meta-Analysis. | Oncol Res Treat | 2016 | Zhang Y | - |
| 28193910 | HIF1/2α mediates hypoxia-induced LDHA expression in human pancreatic cancer cells. | Oncotarget | 2017 Apr 11 | Cui XG | doi: 10.18632/oncotarget.15266. |
| 25913622 | Expression of SIP1 is strongly correlated with LDHA and shows a significantly poor outcome in gastric cancer. | Tumour Biol | 2015 Sep | Sun X | doi: 10.1007/s13277-015-3470-7 |
| 24714743 | Lactate dehydrogenase 5 isoenzyme overexpression defines resistance of prostate cancer to radiotherapy. | Br J Cancer | 2014 Apr 29 | Koukourakis MI | doi: 10.1038/bjc.2014.158 |
| 22429998 | Inhibition of LDH-A by lentivirus-mediated small interfering RNA suppresses intestinal-type gastric cancer tumorigenicity through the downregulation of Oct4. | Cancer Lett | 2012 Aug 1 | Zhang Y | doi: 10.1016/j.canlet.2012.03.013 |
| 24947925 | A novel KLF4/LDHA signaling pathway regulates aerobic glycolysis in and progression of pancreatic cancer. | Clin Cancer Res | 2014 Aug 15 | Shi M | doi: 10.1158/1078-0432.CCR-14-0186 |
| 23404405 | Lactate dehydrogenase A is overexpressed in pancreatic cancer and promotes the growth of pancreatic cancer cells. | Tumour Biol | 2013 Jun | Rong Y | doi: 10.1007/s13277-013-0679-1 |
| 24744144 | LDH5 overexpression is associated with poor survival in patients with solid tumors: a meta-analysis. | Tumour Biol | 2014 Jul | Yao Y | doi: 10.1007/s13277-014-1903-3 |
| 27511116 | Overall survival of cancer patients with serum lactate dehydrogenase greater than 1000IU/L. | Tumour Biol | 2016 Oct | Liu R | - |
| 24608789 | Clinicopathological significance and prognostic value of lactate dehydrogenase A expression in gastric cancer patients. | PLoS One | 2014 Mar 7 | Sun X | doi: 10.1371/journal.pone.0091068 |
| 21969607 | Tyrosine phosphorylation of lactate dehydrogenase A is important for NADH/NAD(+) redox homeostasis in cancer cells. | Mol Cell Biol | 2011 Dec | Fan J | doi: 10.1128/MCB.06120-11 |
| 25333573 | Inhibition of lactate dehydrogenase A by microRNA-34a resensitizes colon cancer cells to 5-fluorouracil. | Mol Med Rep | 2015 Jan | Li X | doi: 10.3892/mmr.2014.2726 |
| 19923867 | Lactate dehydrogenase 5 expression in squamous cell head and neck cancer relates to prognosis following radical or postoperative radiotherapy. | Oncology | 2009 | Koukourakis MI | doi: 10.1159/000259260 |
| 25664730 | Structures of lactate dehydrogenase A (LDHA) in apo, ternary and inhibitor-bound forms. | Acta Crystallogr D Biol Crystallogr | 2015 Feb | Kolappan S | doi: 10.1107/S1399004714024791 |
| 26062441 | Lactate dehydrogenase A negatively regulated by miRNAs promotes aerobic glycolysis and is increased in colorectal cancer. | Oncotarget | 2015 Aug 14 | Wang J | - |
| 26261559 | FOXM1-LDHA signaling promoted gastric cancer glycolytic phenotype and progression. | Int J Clin Exp Pathol | 2015 Jun 1 | Jiang W | - |
| 25524555 | Oxamate-mediated inhibition of lactate dehydrogenase induces protective autophagy in gastric cancer cells: involvement of the Akt-mTOR signaling pathway. | Cancer Lett | 2015 Mar 1 | Zhao Z | doi: 10.1016/j.canlet.2014.11.046 |
| 21632858 | Prognostic and predictive role of lactate dehydrogenase 5 expression in colorectal cancer patients treated with PTK787/ZK 222584 (vatalanib) antiangiogenic therapy. | Clin Cancer Res | 2011 Jul 15 | Koukourakis MI | doi: 10.1158/1078-0432.CCR-10-2918 |
| 24401755 | High lactate dehydrogenase 5 expression correlates with high tumoral and stromal vascular endothelial growth factor expression in gastric cancer. | Pathobiology | 2014 | Kim HS | doi: 10.1159/000357017 |
| 25394466 | Effects of the suppression of lactate dehydrogenase A on the growth and invasion of human gastric cancer cells. | Oncol Rep | 2015 Jan | Liu X | doi: 10.3892/or.2014.3600 |
| 25838393 | Molecular Pathways: Targeting Cellular Energy Metabolism in Cancer via Inhibition of SLC2A1 and LDHA. | Clin Cancer Res | 2015 Jun 1 | Ooi AT | doi: 10.1158/1078-0432.CCR-14-1209 |
| 20385008 | Lactate-dehydrogenase 5 is overexpressed in non-small cell lung cancer and correlates with the expression of the transketolase-like protein 1. | Diagn Pathol | 2010 Apr 12 | Kayser G | doi: 10.1186/1746-1596-5-22. |
| 21452021 | LDH-A silencing suppresses breast cancer tumorigenicity through induction of oxidative stress mediated mitochondrial pathway apoptosis. | Breast Cancer Res Treat | 2012 Feb | Wang ZY | doi: 10.1007/s10549-011-1466-6 |
| 21249322 | Lactate dehydrogenase, Gleason score and HER-2 overexpression are significant prognostic factors for M1b prostate cancer. | Oncol Rep | 2011 Apr | Yamada Y | doi: 10.3892/or.2011.1154 |
| 27566995 | Lactate dehydrogenase downregulation mediates the inhibitory effect of diallyl trisulfide on proliferation, metastasis, and invasion in triple-negative breast cancer. | Environ Toxicol | 2017 Apr | Cheng SY | doi: 10.1002/tox.22333 |
| 28314283 | Stable shRNA Silencing of Lactate Dehydrogenase A (LDHA) in Human MDA-MB-231 Breast Cancer Cells Fails to Alter Lactic Acid Production, Glycolytic Activity, ATP or Survival. | Anticancer Res | 2017 Mar | Mack N | - |
| 28218905 | Phosphorylation-mediated activation of LDHA promotes cancer cell invasion and tumour metastasis. | Oncogene | 2017 Jul 6 | Jin L | doi: 10.1038/onc.2017.6 |
| 27150057 | Upregulation of lactate dehydrogenase a by 14-3-3?? leads to increased glycolysis critical for breast cancer initiation and progression. | Oncotarget | 2016 Jun 7 | Chang CC | doi: 10.18632/oncotarget.9136. |
| 27223065 | Prognostic value of preoperative serum lactate dehydrogenase levels for resectable gastric cancer and prognostic nomograms. | Oncotarget | 2016 Jun 28 | Wang ZX | doi: 10.18632/oncotarget.9459. |
| 28915924 | PDL1 And LDHA act as ceRNAs in triple negative breast cancer by regulating miR-34a. | J Exp Clin Cancer Res | 2017 Sep 15 | Huang X | doi: 10.1186/s13046-017-0593-2. |
| 30197328 | Correlation of serum lactate dehydrogenase and alkaline phosphatase in different histological grades of head and neck squamous cell carcinoma and premalignant lesions. | J Cancer Res Ther | 2018 Jul-Sep | Bhattacharjee A | doi: 10.4103/0973-1482.172718. |
| 29970686 | Clinical evaluation of potential usefulness of serum lactate dehydrogenase level in follow-up of small cell lung cancer. | J Cancer Res Ther | 2018 Jun | Chen C | doi: 10.4103/0973-1482.168994. |
| 30015851 | miR199a3p/Sp1/LDHA axis controls aerobic glycolysis in testicular tumor cells. | Int J Mol Med | 2018 Oct | Zhou S | doi: 10.3892/ijmm.2018.3771 |
| 29321091 | The Downregulation of miR-200c Promotes Lactate Dehydrogenase A Expression and Non-Small Cell Lung Cancer Progression. | Oncol Res | 2018 Aug 23 | Lei W | doi: 10.3727/096504018X15151486241153 |
| 28516914 | Adenylate kinase hCINAP determines self-renewal of colorectal cancer stem cells by facilitating LDHA phosphorylation. | Nat Commun | 2017 May 18 | Ji Y | doi: 10.1038/ncomms15308. |
| 29569755 | LDHA is a direct target of miR-30d-5p and contributes to aggressive progression of gallbladder carcinoma. | Mol Carcinog | 2018 Jun | He Y | doi: 10.1002/mc.22799 |
