EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
28729678	Tumor LDH-A expression and serum LDH status are two metabolic predictors for triple negative breast cancer brain metastasis.	Sci Rep	2017 Jul 20	Dong T	doi: 10.1038/s41598-017-06378-7.
24366912	Lactate dehydrogenase A silencing in IDH mutant gliomas.	Neuro Oncol	2014 May	Chesnelong C	doi: 10.1093/neuonc/not243
25983002	Inhibition of LDHA suppresses tumor progression in prostate cancer.	Tumour Biol	2015 Sep	Xian ZY	doi: 10.1007/s13277-015-3540-x
25762632	JQ1 suppresses tumor growth through downregulating LDHA in ovarian cancer.	Oncotarget	2015 Mar 30	Qiu H	-
26902416	The miR-34a-LDHA axis regulates glucose metabolism and tumor growth in breast cancer.	Sci Rep	2016 Feb 23	Xiao X	doi: 10.1038/srep21735.
27622920	Lactate dehydrogenase inhibitors can reverse inflammation induced changes in colon cancer cells.	Eur J Pharm Sci	2017 Jan 1	Manerba M	doi: 10.1016/j.ejps.2016.09.014
28461244	miR-30a-5p suppresses breast tumor growth and metastasis through inhibition of LDHA-mediated Warburg effect.	Cancer Lett	2017 Aug 1	Li L	doi: 10.1016/j.canlet.2017.04.034
30618169	p53/Lactate dehydrogenase A axis negatively regulates aerobic glycolysis and tumor progression in breast cancer expressing wild-type p53.	Cancer Sci	2019 Mar	Zhou Y	doi: 10.1111/cas.13928
25791837	Melanoma brain metastasis is independent of lactate dehydrogenase A expression.	Neuro Oncol	2015 Oct	Sundstrm T	doi: 10.1093/neuonc/nov040
19276158	LDH-A inhibition, a therapeutic strategy for treatment of hereditary leiomyomatosis and renal cell cancer.	Mol Cancer Ther	2009 Mar	Xie H	doi: 10.1158/1535-7163.MCT-08-1049
16132575	Lactate dehydrogenase 5 (LDH5) relates to up-regulated hypoxia inducible factor pathway and metastasis in colorectal cancer.	Clin Exp Metastasis	2005	Koukourakis MI	-
22897481	Knockdown of lactate dehydrogenase A suppresses tumor growth and metastasis of human hepatocellular carcinoma.	FEBS J	2012 Oct	Sheng SL	doi: 10.1111/j.1742-4658.2012.08748.x
27641098	LDHA-Associated Lactic Acid Production Blunts Tumor Immunosurveillance by T and NK Cells.	Cell Metab	2016 Nov 8	Brand A	doi: 10.1016/j.cmet.2016.08.011
27374173	miR-200b is a key regulator of tumor progression and metabolism targeting lactate dehydrogenase A in human malignant glioma.	Oncotarget	2016 Jul 26	Hu S	doi: 10.18632/oncotarget.10301.
29360449	miR-142-3p inhibits aerobic glycolysis and cell proliferation in hepatocellular carcinoma via targeting LDHA.	Biochem Biophys Res Commun	2018 Feb 12	Hua S	doi: 10.1016/j.bbrc.2018.01.112.
27432288	microRNA-199a-3p functions as tumor suppressor by regulating glucose metabolism in testicular germ cell tumors.	Mol Med Rep	2016 Sep	Liu X	doi: 10.3892/mmr.2016.5472
18821170	Differentiated expression of the lactate dehydrogenase subunit M in pleural fluids of neoplastic aetiology.	Scand J Clin Lab Invest	2009	Kotyza J	doi: 10.1080/00365510802406626.
27710971	Prognostic Role of Lactate Dehydrogenase Expression in Urologic Cancers: A Systematic Review and Meta-Analysis.	Oncol Res Treat	2016	Zhang Y	-
28193910	HIF1/2α mediates hypoxia-induced LDHA expression in human pancreatic cancer cells.	Oncotarget	2017 Apr 11	Cui XG	doi: 10.18632/oncotarget.15266.
25913622	Expression of SIP1 is strongly correlated with LDHA and shows a significantly poor outcome in gastric cancer.	Tumour Biol	2015 Sep	Sun X	doi: 10.1007/s13277-015-3470-7
24714743	Lactate dehydrogenase 5 isoenzyme overexpression defines resistance of prostate cancer to radiotherapy.	Br J Cancer	2014 Apr 29	Koukourakis MI	doi: 10.1038/bjc.2014.158
22429998	Inhibition of LDH-A by lentivirus-mediated small interfering RNA suppresses intestinal-type gastric cancer tumorigenicity through the downregulation of Oct4.	Cancer Lett	2012 Aug 1	Zhang Y	doi: 10.1016/j.canlet.2012.03.013
24947925	A novel KLF4/LDHA signaling pathway regulates aerobic glycolysis in and progression of pancreatic cancer.	Clin Cancer Res	2014 Aug 15	Shi M	doi: 10.1158/1078-0432.CCR-14-0186
23404405	Lactate dehydrogenase A is overexpressed in pancreatic cancer and promotes the growth of pancreatic cancer cells.	Tumour Biol	2013 Jun	Rong Y	doi: 10.1007/s13277-013-0679-1
24744144	LDH5 overexpression is associated with poor survival in patients with solid tumors: a meta-analysis.	Tumour Biol	2014 Jul	Yao Y	doi: 10.1007/s13277-014-1903-3
27511116	Overall survival of cancer patients with serum lactate dehydrogenase greater than 1000IU/L.	Tumour Biol	2016 Oct	Liu R	-
24608789	Clinicopathological significance and prognostic value of lactate dehydrogenase A expression in gastric cancer patients.	PLoS One	2014 Mar 7	Sun X	doi: 10.1371/journal.pone.0091068
21969607	Tyrosine phosphorylation of lactate dehydrogenase A is important for NADH/NAD(+) redox homeostasis in cancer cells.	Mol Cell Biol	2011 Dec	Fan J	doi: 10.1128/MCB.06120-11
25333573	Inhibition of lactate dehydrogenase A by microRNA-34a resensitizes colon cancer cells to 5-fluorouracil.	Mol Med Rep	2015 Jan	Li X	doi: 10.3892/mmr.2014.2726
19923867	Lactate dehydrogenase 5 expression in squamous cell head and neck cancer relates to prognosis following radical or postoperative radiotherapy.	Oncology	2009	Koukourakis MI	doi: 10.1159/000259260
25664730	Structures of lactate dehydrogenase A (LDHA) in apo, ternary and inhibitor-bound forms.	Acta Crystallogr D Biol Crystallogr	2015 Feb	Kolappan S	doi: 10.1107/S1399004714024791
26062441	Lactate dehydrogenase A negatively regulated by miRNAs promotes aerobic glycolysis and is increased in colorectal cancer.	Oncotarget	2015 Aug 14	Wang J	-
26261559	FOXM1-LDHA signaling promoted gastric cancer glycolytic phenotype and progression.	Int J Clin Exp Pathol	2015 Jun 1	Jiang W	-
25524555	Oxamate-mediated inhibition of lactate dehydrogenase induces protective autophagy in gastric cancer cells: involvement of the Akt-mTOR signaling pathway.	Cancer Lett	2015 Mar 1	Zhao Z	doi: 10.1016/j.canlet.2014.11.046
21632858	Prognostic and predictive role of lactate dehydrogenase 5 expression in colorectal cancer patients treated with PTK787/ZK 222584 (vatalanib) antiangiogenic therapy.	Clin Cancer Res	2011 Jul 15	Koukourakis MI	doi: 10.1158/1078-0432.CCR-10-2918
24401755	High lactate dehydrogenase 5 expression correlates with high tumoral and stromal vascular endothelial growth factor expression in gastric cancer.	Pathobiology	2014	Kim HS	doi: 10.1159/000357017
25394466	Effects of the suppression of lactate dehydrogenase A on the growth and invasion of human gastric cancer cells.	Oncol Rep	2015 Jan	Liu X	doi: 10.3892/or.2014.3600
25838393	Molecular Pathways: Targeting Cellular Energy Metabolism in Cancer via Inhibition of SLC2A1 and LDHA.	Clin Cancer Res	2015 Jun 1	Ooi AT	doi: 10.1158/1078-0432.CCR-14-1209
20385008	Lactate-dehydrogenase 5 is overexpressed in non-small cell lung cancer and correlates with the expression of the transketolase-like protein 1.	Diagn Pathol	2010 Apr 12	Kayser G	doi: 10.1186/1746-1596-5-22.
21452021	LDH-A silencing suppresses breast cancer tumorigenicity through induction of oxidative stress mediated mitochondrial pathway apoptosis.	Breast Cancer Res Treat	2012 Feb	Wang ZY	doi: 10.1007/s10549-011-1466-6
21249322	Lactate dehydrogenase, Gleason score and HER-2 overexpression are significant prognostic factors for M1b prostate cancer.	Oncol Rep	2011 Apr	Yamada Y	doi: 10.3892/or.2011.1154
27566995	Lactate dehydrogenase downregulation mediates the inhibitory effect of diallyl trisulfide on proliferation, metastasis, and invasion in triple-negative breast cancer.	Environ Toxicol	2017 Apr	Cheng SY	doi: 10.1002/tox.22333
28314283	Stable shRNA Silencing of Lactate Dehydrogenase A (LDHA) in Human MDA-MB-231 Breast Cancer Cells Fails to Alter Lactic Acid Production, Glycolytic Activity, ATP or Survival.	Anticancer Res	2017 Mar	Mack N	-
28218905	Phosphorylation-mediated activation of LDHA promotes cancer cell invasion and tumour metastasis.	Oncogene	2017 Jul 6	Jin L	doi: 10.1038/onc.2017.6
27150057	Upregulation of lactate dehydrogenase a by 14-3-3?? leads to increased glycolysis critical for breast cancer initiation and progression.	Oncotarget	2016 Jun 7	Chang CC	doi: 10.18632/oncotarget.9136.
27223065	Prognostic value of preoperative serum lactate dehydrogenase levels for resectable gastric cancer and prognostic nomograms.	Oncotarget	2016 Jun 28	Wang ZX	doi: 10.18632/oncotarget.9459.
28915924	PDL1 And LDHA act as ceRNAs in triple negative breast cancer by regulating miR-34a.	J Exp Clin Cancer Res	2017 Sep 15	Huang X	doi: 10.1186/s13046-017-0593-2.
30197328	Correlation of serum lactate dehydrogenase and alkaline phosphatase in different histological grades of head and neck squamous cell carcinoma and premalignant lesions.	J Cancer Res Ther	2018 Jul-Sep	Bhattacharjee A	doi: 10.4103/0973-1482.172718.
29970686	Clinical evaluation of potential usefulness of serum lactate dehydrogenase level in follow-up of small cell lung cancer.	J Cancer Res Ther	2018 Jun	Chen C	doi: 10.4103/0973-1482.168994.
30015851	miR199a3p/Sp1/LDHA axis controls aerobic glycolysis in testicular tumor cells.	Int J Mol Med	2018 Oct	Zhou S	doi: 10.3892/ijmm.2018.3771
29321091	The Downregulation of miR-200c Promotes Lactate Dehydrogenase A Expression and Non-Small Cell Lung Cancer Progression.	Oncol Res	2018 Aug 23	Lei W	doi: 10.3727/096504018X15151486241153
28516914	Adenylate kinase hCINAP determines self-renewal of colorectal cancer stem cells by facilitating LDHA phosphorylation.	Nat Commun	2017 May 18	Ji Y	doi: 10.1038/ncomms15308.
29569755	LDHA is a direct target of miR-30d-5p and contributes to aggressive progression of gallbladder carcinoma.	Mol Carcinog	2018 Jun	He Y	doi: 10.1002/mc.22799

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
ACC	chr11	18407368	3'UTR	novel		0.67
ACC	chr11	18400932	Missense_Mutation	novel	V114M	0.58
BRCA	chr11	18396589	5'UTR	novel		0.28
BRCA	chr11	18400953	Missense_Mutation	rs746460566	I121V	0.1
BRCA	chr11	18407213	Missense_Mutation	NA	E311K	0.28
BRCA	chr11	18407635	3'UTR	novel		0.12
BRCA	chr11	18396924	Missense_Mutation	NA	V28I	0.2
BRCA	chr11	18407427	3'UTR	novel		0.2
CESC	chr11	18400887	Missense_Mutation	rs763532603	R99C	0.39
CESC	chr11	18407529	3'UTR	novel		0.55
CESC	chr11	18407568	3'UTR	novel		0.41
CESC	chr11	18396519	5'UTR	novel		0.26
COAD	chr11	18396895	Frame_Shift_Del	NA	*Q20Rfs21**	0.41
COAD	chr11	18402943	Frame_Shift_Del	NA	*E176Kfs8**	0.28
COAD	chr11	18399466	Silent	rs200075826	I54I	0.38
COAD	chr11	18403779	Frame_Shift_Ins	novel	*W227Tfs16**	0.06
COAD	chr11	18407495	3'UTR	novel		0.21
COAD	chr11	18407497	3'UTR	novel		0.12
GBM	chr11	18407154	Missense_Mutation	novel	V291A	0.45
GBM	chr11	18407171	Nonsense_Mutation	NA	Q297*	0.73
GBM	chr11	18399505	Missense_Mutation	novel	H67Q	0.1
HNSC	chr11	18407316	3'UTR	novel		0.17
HNSC	chr11	18400908	Missense_Mutation	novel	R106C	0.08
LAML	chr11	18407424	3'UTR	novel		0.12
LUAD	chr11	18396896	Silent	NA	T18T	0.12
LUAD	chr11	18403807	Nonsense_Mutation	novel	E236*	0.1
LUAD	chr11	18402945	Missense_Mutation	novel	G175V	0.21
LUAD	chr11	18407243	Missense_Mutation	rs200019907	D321N	0.19
LUAD	chr11	18405540	Frame_Shift_Del	novel	*R268Gfs9**	0.08
LUAD	chr11	18399543	Missense_Mutation	NA	G80V	0.17
LUAD	chr11	18402980	Missense_Mutation	novel	G187W	0.13
OV	chr11	18405555	In_Frame_Ins	novel	V273delinsAQERNTI	0.07
OV	chr11	18403807	Missense_Mutation	NA	E236Q	0.16
SKCM	chr11	18396891	Frame_Shift_Ins	novel	*T18Rfs24**	0.44
SKCM	chr11	18403747	Missense_Mutation	NA	P216S	0.09
SKCM	chr11	18407191	In_Frame_Del	novel	V304_S310del	0.29
SKCM	chr11	18399518	Missense_Mutation	NA	L72F	0.5
SKCM	chr11	18403790	Missense_Mutation	NA	V230A	0.47
SKCM	chr11	18407353	3'UTR	novel		0.38
SKCM	chr11	18402932	Missense_Mutation	rs752156024	R171C	0.29
SKCM	chr11	18403807	Nonsense_Mutation	novel	E236*	0.32
SKCM	chr11	18407156	Missense_Mutation	novel	P292S	0.11
STAD	chr11	18405503	Frame_Shift_Del	novel	*V256Sfs12**	0.21
STAD	chr11	18402890	Missense_Mutation	novel	R157C	0.08
STAD	chr11	18400950	Missense_Mutation	NA	I120L	0.25
STAD	chr11	18399467	Missense_Mutation	rs144856598	E55K	0.33
STAD	chr11	18399494	Missense_Mutation	novel	D64N	0.11
STAD	chr11	18402995	Missense_Mutation	novel	E192K	0.14
STAD	chr11	18407173	Silent	novel	Q297Q	0.32
STAD	chr11	18407369	3'UTR	rs562694907		0.24
STAD	chr11	18396895	Frame_Shift_Del	NA	*Q20Rfs21**	0.38
STAD	chr11	18396895	Frame_Shift_Del	NA	*Q20Rfs21**	0.38
STAD	chr11	18399546	Missense_Mutation	novel	K81R	0.24
STAD	chr11	18407200	Silent	NA	V306V	0.35
STAD	chr11	18402933	Missense_Mutation	rs760172008	R171H	0.39
THCA	chr11	18399512	Missense_Mutation	NA	L70V	0.4
THCA	chr11	18405493	Missense_Mutation	NA	I252T	0.06
UCEC	chr11	18399455	Missense_Mutation	rs758645316	V51I	0.35
UCEC	chr11	18407163	Frame_Shift_Del	novel	*L295Wfs10**	0.44
UCEC	chr11	18405507	Missense_Mutation	NA	A257T	0.39
UCEC	chr11	18403014	Splice_Site	NA	X198_splice	0.12
UCEC	chr11	18407226	Missense_Mutation	rs140090654	R315H	0.06
UCEC	chr11	18396863	Silent	NA	Q7Q	0.37
UCEC	chr11	18407226	Missense_Mutation	rs140090654	R315H	0.41
UCEC	chr11	18400878	Missense_Mutation	novel	A96T	0.46
UCEC	chr11	18396965	Missense_Mutation	novel	M41I	0.11
UCEC	chr11	18407370	3'UTR	rs200441639		0.19
UCEC	chr11	18396580	5'UTR	novel		0.32
UCEC	chr11	18396918	Missense_Mutation	NA	V26L	0.1
UCEC	chr11	18400884	Missense_Mutation	novel	A98S	0.33
UCEC	chr11	18407427	3'UTR	novel		0.42
UCEC	chr11	18399467	Missense_Mutation	rs144856598	E55K	0.53
UCEC	chr11	18407549	3'UTR	novel		0.36
UCEC	chr11	18407592	3'UTR	rs200079157		0.5
UCEC	chr11	18396847	Missense_Mutation	novel	A2G	0.18
UCEC	chr11	18407283	3'UTR	novel		0.33
UCEC	chr11	18407642	3'UTR	novel		0.48
UCEC	chr11	18396411	5'UTR	novel		0.38
UCEC	chr11	18396908	Missense_Mutation	NA	K22N	0.25
UCEC	chr11	18407384	3'UTR	novel		0.41
UCEC	chr11	18396954	Missense_Mutation	NA	S38G	0.24
UCEC	chr11	18407329	3'UTR	NA		0.14
UCEC	chr11	18407484	3'UTR	novel		0.22
UCEC	chr11	18399534	Missense_Mutation	novel	I77T	0.06
UCEC	chr11	18396580	5'UTR	novel		0.49
UCEC	chr11	18407339	3'UTR	rs771712815		0.4

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
CESC	DEL	0.2746	0.02701
ESCA	AMP	0.1413	0.018342
PCPG	AMP	0.0309	0.23196
TGCT	DEL	0.5467	0.21504

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.043	Kaplan-Meier Survival Analysis
ACC	0.0053	Kaplan-Meier Survival Analysis
HNSC	0.0022	Kaplan-Meier Survival Analysis
PRAD	0.034	Kaplan-Meier Survival Analysis
KIRP	0.018	Kaplan-Meier Survival Analysis
PAAD	0.0001	Kaplan-Meier Survival Analysis
BLCA	0.016	Kaplan-Meier Survival Analysis
CESC	0.00039	Kaplan-Meier Survival Analysis
READ	0.049	Kaplan-Meier Survival Analysis
KICH	0.00096	Kaplan-Meier Survival Analysis
GBM	0.0018	Kaplan-Meier Survival Analysis
LIHC	0.0001	Kaplan-Meier Survival Analysis
LGG	0.0001	Kaplan-Meier Survival Analysis
LUAD	0.00012	Kaplan-Meier Survival Analysis
OV	0.027	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathway

Phenotype

GWAS

PPI

Ortholog

Gene Ontology

Description

Ensembl ID: ENSG00000134333 (Gene tree)
Gene ID: 3939
Gene Symbol: LDHA
Alias: N
Full Name: lactate dehydrogenase A
Gene Type: protein_coding
Specie: Homo_sapiens
Strand: Plus strand
Length: 14,038 bases
Position: chr11:18,394,388-18,408,425
Accession: 6535
Summary: The protein encoded by this gene catalyzes the conversion of L-lactate and NAD to pyruvate and NADH in the final step of anaerobic glycolysis. The protein is found predominantly in muscle tissue and belongs to the lactate dehydrogenase family. Mutations in this gene have been linked to exertional myoglobinuria. Multiple transcript variants encoding different isoforms have been found for this gene. The human genome contains several non-transcribed pseudogenes of this gene. [provided by RefSeq, Sep 2008]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
30136864	Gordon H. Dixon's trace in my personal career and the quantic jump experienced in regulatory information.	Syst Biol Reprod Med	2018 Dec	Mezquita-Pla J	doi: 10.1080/19396368.2018.1503752
23237800	Galloflavin prevents the binding of lactate dehydrogenase A to single stranded DNA and inhibits RNA synthesis in cultured cells.	Biochem Biophys Res Commun	2013 Jan 11	Fiume L	doi: 10.1016/j.bbrc.2012.12.013

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000430553	LDHA-206	1310	-	ENSP00000406172	274 (aa)	-	P00338
ENST00000396222	LDHA-204	1766	-	ENSP00000379524	274 (aa)	-	P00338
ENST00000375710	LDHA-202	2169	-	-	- (aa)	-	-
ENST00000542179	LDHA-220	1288	-	ENSP00000445331	332 (aa)	-	P00338
ENST00000494573	LDHA-211	1154	-	-	- (aa)	-	-
ENST00000478970	LDHA-209	732	-	ENSP00000441241	144 (aa)	-	F5GYU2
ENST00000540430	LDHA-218	2305	-	ENSP00000445175	361 (aa)	-	P00338
ENST00000422447	LDHA-205	2416	-	ENSP00000395337	332 (aa)	-	P00338
ENST00000535451	LDHA-213	465	-	ENSP00000444292	72 (aa)	-	F5GZQ4
ENST00000539814	LDHA-217	556	-	ENSP00000442979	94 (aa)	-	F5H6W8
ENST00000469976	LDHA-208	656	-	-	- (aa)	-	-
ENST00000545467	LDHA-224	570	-	ENSP00000443545	42 (aa)	-	F5H8H6
ENST00000460405	LDHA-207	680	-	-	- (aa)	-	-
ENST00000495052	LDHA-212	682	-	ENSP00000446415	114 (aa)	-	F5GXH2
ENST00000379412	LDHA-203	1922	-	ENSP00000368722	332 (aa)	-	P00338
ENST00000541097	LDHA-219	582	-	ENSP00000443362	89 (aa)	-	F5H5J4
ENST00000543445	LDHA-221	576	-	ENSP00000440161	156 (aa)	-	F5GXY2
ENST00000537296	LDHA-215	1511	-	-	- (aa)	-	-
ENST00000536528	LDHA-214	516	-	ENSP00000441058	45 (aa)	-	F5GXC7
ENST00000227157	LDHA-201	1887	-	ENSP00000227157	241 (aa)	-	P00338
ENST00000625635	LDHA-225	141	-	ENSP00000486249	46 (aa)	-	F5GXU1
ENST00000538451	LDHA-216	1345	-	-	- (aa)	-	-
ENST00000486690	LDHA-210	664	-	ENSP00000441699	45 (aa)	-	F5GWW2
ENST00000543695	LDHA-222	554	-	ENSP00000440368	46 (aa)	-	F5GXU1
ENST00000545215	LDHA-223	1340	-	ENSP00000442637	45 (aa)	-	F5GWW2

Gene Model

Click here to download 's gene model file

Pathway

Pathway ID	Pathway Name	Source
hsa00010	Glycolysis / Gluconeogenesis	KEGG
hsa00270	Cysteine and methionine metabolism	KEGG
hsa00620	Pyruvate metabolism	KEGG
hsa00640	Propanoate metabolism	KEGG
hsa01100	Metabolic pathways	KEGG
hsa04066	HIF-1 signaling pathway	KEGG
hsa04922	Glucagon signaling pathway	KEGG
hsa05230	Central carbon metabolism in cancer	KEGG

Phenotype

ensgID	Trait	pValue	Pubmed ID
ENSG00000134333	Serum Amyloid A Protein	4E-22	21124955

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000134333	rs2896526	11	18398259	G	Amyloid A serum levels	21124955	[0.17-0.27] unit increase	0.221	EFO_0004728

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000134333's network

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy	Species
ENSG00000134333	LDHA	100	95.833	ENSMUSG00000063229	Ldha	100	95.588	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0001666	response to hypoxia	-	IEA	Process
GO:0004459	L-lactate dehydrogenase activity	1953713.	NAS	Function
GO:0005515	protein binding	23523103.	IPI	Function
GO:0005634	nucleus	21630459.	HDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0006089	lactate metabolic process	-	IEA	Process
GO:0006090	pyruvate metabolic process	-	TAS	Process
GO:0006096	glycolytic process	1953713.	NAS	Process
GO:0007584	response to nutrient	-	IEA	Process
GO:0009749	response to glucose	-	IEA	Process
GO:0016020	membrane	19946888.	HDA	Component
GO:0019674	NAD metabolic process	-	IEA	Process
GO:0019900	kinase binding	-	IEA	Function
GO:0042542	response to hydrogen peroxide	-	IEA	Process
GO:0042802	identical protein binding	-	IEA	Function
GO:0043065	positive regulation of apoptotic process	-	IEA	Process
GO:0043627	response to estrogen	-	IEA	Process
GO:0045296	cadherin binding	25468996.	HDA	Function
GO:0048569	post-embryonic animal organ development	-	IEA	Process
GO:0051287	NAD binding	-	IEA	Function
GO:0051591	response to cAMP	-	IEA	Process
GO:0055114	oxidation-reduction process	-	IEA	Process
GO:0070062	extracellular exosome	11487543.19056867.20458337.23533145.	HDA	Component

EuRBPDB

Note: to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathway

Phenotype

GWAS

PPI

Ortholog

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.