EuRBPDB

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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
28729678Tumor LDH-A expression and serum LDH status are two metabolic predictors for triple negative breast cancer brain metastasis.Sci Rep2017 Jul 20Dong Tdoi: 10.1038/s41598-017-06378-7.
24366912Lactate dehydrogenase A silencing in IDH mutant gliomas.Neuro Oncol2014 MayChesnelong Cdoi: 10.1093/neuonc/not243
25983002Inhibition of LDHA suppresses tumor progression in prostate cancer.Tumour Biol2015 SepXian ZYdoi: 10.1007/s13277-015-3540-x
25762632JQ1 suppresses tumor growth through downregulating LDHA in ovarian cancer.Oncotarget2015 Mar 30Qiu H-
26902416The miR-34a-LDHA axis regulates glucose metabolism and tumor growth in breast cancer.Sci Rep2016 Feb 23Xiao Xdoi: 10.1038/srep21735.
27622920Lactate dehydrogenase inhibitors can reverse inflammation induced changes in colon cancer cells.Eur J Pharm Sci2017 Jan 1Manerba Mdoi: 10.1016/j.ejps.2016.09.014
28461244miR-30a-5p suppresses breast tumor growth and metastasis through inhibition of LDHA-mediated Warburg effect.Cancer Lett2017 Aug 1Li Ldoi: 10.1016/j.canlet.2017.04.034
30618169p53/Lactate dehydrogenase A axis negatively regulates aerobic glycolysis and tumor progression in breast cancer expressing wild-type p53.Cancer Sci2019 MarZhou Ydoi: 10.1111/cas.13928
25791837Melanoma brain metastasis is independent of lactate dehydrogenase A expression.Neuro Oncol2015 OctSundstrm Tdoi: 10.1093/neuonc/nov040
19276158LDH-A inhibition, a therapeutic strategy for treatment of hereditary leiomyomatosis and renal cell cancer.Mol Cancer Ther2009 MarXie Hdoi: 10.1158/1535-7163.MCT-08-1049
16132575Lactate dehydrogenase 5 (LDH5) relates to up-regulated hypoxia inducible factor pathway and metastasis in colorectal cancer.Clin Exp Metastasis2005Koukourakis MI-
22897481Knockdown of lactate dehydrogenase A suppresses tumor growth and metastasis of human hepatocellular carcinoma.FEBS J2012 OctSheng SLdoi: 10.1111/j.1742-4658.2012.08748.x
27641098LDHA-Associated Lactic Acid Production Blunts Tumor Immunosurveillance by T and NK Cells.Cell Metab2016 Nov 8Brand Adoi: 10.1016/j.cmet.2016.08.011
27374173miR-200b is a key regulator of tumor progression and metabolism targeting lactate dehydrogenase A in human malignant glioma.Oncotarget2016 Jul 26Hu Sdoi: 10.18632/oncotarget.10301.
29360449miR-142-3p inhibits aerobic glycolysis and cell proliferation in hepatocellular carcinoma via targeting LDHA.Biochem Biophys Res Commun2018 Feb 12Hua Sdoi: 10.1016/j.bbrc.2018.01.112.
27432288microRNA-199a-3p functions as tumor suppressor by regulating glucose metabolism in testicular germ cell tumors.Mol Med Rep2016 SepLiu Xdoi: 10.3892/mmr.2016.5472
18821170Differentiated expression of the lactate dehydrogenase subunit M in pleural fluids of neoplastic aetiology.Scand J Clin Lab Invest2009Kotyza Jdoi: 10.1080/00365510802406626.
27710971Prognostic Role of Lactate Dehydrogenase Expression in Urologic Cancers: A Systematic Review and Meta-Analysis.Oncol Res Treat2016Zhang Y-
28193910HIF1/2α mediates hypoxia-induced LDHA expression in human pancreatic cancer cells.Oncotarget2017 Apr 11Cui XGdoi: 10.18632/oncotarget.15266.
25913622Expression of SIP1 is strongly correlated with LDHA and shows a significantly poor outcome in gastric cancer.Tumour Biol2015 SepSun Xdoi: 10.1007/s13277-015-3470-7
24714743Lactate dehydrogenase 5 isoenzyme overexpression defines resistance of prostate cancer to radiotherapy.Br J Cancer2014 Apr 29Koukourakis MIdoi: 10.1038/bjc.2014.158
22429998Inhibition of LDH-A by lentivirus-mediated small interfering RNA suppresses intestinal-type gastric cancer tumorigenicity through the downregulation of Oct4.Cancer Lett2012 Aug 1Zhang Ydoi: 10.1016/j.canlet.2012.03.013
24947925A novel KLF4/LDHA signaling pathway regulates aerobic glycolysis in and progression of pancreatic cancer.Clin Cancer Res2014 Aug 15Shi Mdoi: 10.1158/1078-0432.CCR-14-0186
23404405Lactate dehydrogenase A is overexpressed in pancreatic cancer and promotes the growth of pancreatic cancer cells.Tumour Biol2013 JunRong Ydoi: 10.1007/s13277-013-0679-1
24744144LDH5 overexpression is associated with poor survival in patients with solid tumors: a meta-analysis.Tumour Biol2014 JulYao Ydoi: 10.1007/s13277-014-1903-3
27511116Overall survival of cancer patients with serum lactate dehydrogenase greater than 1000IU/L.Tumour Biol2016 OctLiu R-
24608789Clinicopathological significance and prognostic value of lactate dehydrogenase A expression in gastric cancer patients.PLoS One2014 Mar 7Sun Xdoi: 10.1371/journal.pone.0091068
21969607Tyrosine phosphorylation of lactate dehydrogenase A is important for NADH/NAD(+) redox homeostasis in cancer cells.Mol Cell Biol2011 DecFan Jdoi: 10.1128/MCB.06120-11
25333573Inhibition of lactate dehydrogenase A by microRNA-34a resensitizes colon cancer cells to 5-fluorouracil.Mol Med Rep2015 JanLi Xdoi: 10.3892/mmr.2014.2726
19923867Lactate dehydrogenase 5 expression in squamous cell head and neck cancer relates to prognosis following radical or postoperative radiotherapy.Oncology2009Koukourakis MIdoi: 10.1159/000259260
25664730Structures of lactate dehydrogenase A (LDHA) in apo, ternary and inhibitor-bound forms.Acta Crystallogr D Biol Crystallogr2015 FebKolappan Sdoi: 10.1107/S1399004714024791
26062441Lactate dehydrogenase A negatively regulated by miRNAs promotes aerobic glycolysis and is increased in colorectal cancer.Oncotarget2015 Aug 14Wang J-
26261559FOXM1-LDHA signaling promoted gastric cancer glycolytic phenotype and progression.Int J Clin Exp Pathol2015 Jun 1Jiang W-
25524555Oxamate-mediated inhibition of lactate dehydrogenase induces protective autophagy in gastric cancer cells: involvement of the Akt-mTOR signaling pathway.Cancer Lett2015 Mar 1Zhao Zdoi: 10.1016/j.canlet.2014.11.046
21632858Prognostic and predictive role of lactate dehydrogenase 5 expression in colorectal cancer patients treated with PTK787/ZK 222584 (vatalanib) antiangiogenic therapy.Clin Cancer Res2011 Jul 15Koukourakis MIdoi: 10.1158/1078-0432.CCR-10-2918
24401755High lactate dehydrogenase 5 expression correlates with high tumoral and stromal vascular endothelial growth factor expression in gastric cancer.Pathobiology2014Kim HSdoi: 10.1159/000357017
25394466Effects of the suppression of lactate dehydrogenase A on the growth and invasion of human gastric cancer cells.Oncol Rep2015 JanLiu Xdoi: 10.3892/or.2014.3600
25838393Molecular Pathways: Targeting Cellular Energy Metabolism in Cancer via Inhibition of SLC2A1 and LDHA.Clin Cancer Res2015 Jun 1Ooi ATdoi: 10.1158/1078-0432.CCR-14-1209
20385008Lactate-dehydrogenase 5 is overexpressed in non-small cell lung cancer and correlates with the expression of the transketolase-like protein 1.Diagn Pathol2010 Apr 12Kayser Gdoi: 10.1186/1746-1596-5-22.
21452021LDH-A silencing suppresses breast cancer tumorigenicity through induction of oxidative stress mediated mitochondrial pathway apoptosis.Breast Cancer Res Treat2012 FebWang ZYdoi: 10.1007/s10549-011-1466-6
21249322Lactate dehydrogenase, Gleason score and HER-2 overexpression are significant prognostic factors for M1b prostate cancer.Oncol Rep2011 AprYamada Ydoi: 10.3892/or.2011.1154
27566995Lactate dehydrogenase downregulation mediates the inhibitory effect of diallyl trisulfide on proliferation, metastasis, and invasion in triple-negative breast cancer.Environ Toxicol2017 AprCheng SYdoi: 10.1002/tox.22333
28314283Stable shRNA Silencing of Lactate Dehydrogenase A (LDHA) in Human MDA-MB-231 Breast Cancer Cells Fails to Alter Lactic Acid Production, Glycolytic Activity, ATP or Survival.Anticancer Res2017 MarMack N-
28218905Phosphorylation-mediated activation of LDHA promotes cancer cell invasion and tumour metastasis.Oncogene2017 Jul 6Jin Ldoi: 10.1038/onc.2017.6
27150057Upregulation of lactate dehydrogenase a by 14-3-3?? leads to increased glycolysis critical for breast cancer initiation and progression.Oncotarget2016 Jun 7Chang CCdoi: 10.18632/oncotarget.9136.
27223065Prognostic value of preoperative serum lactate dehydrogenase levels for resectable gastric cancer and prognostic nomograms.Oncotarget2016 Jun 28Wang ZXdoi: 10.18632/oncotarget.9459.
28915924PDL1 And LDHA act as ceRNAs in triple negative breast cancer by regulating miR-34a.J Exp Clin Cancer Res2017 Sep 15Huang Xdoi: 10.1186/s13046-017-0593-2.
30197328Correlation of serum lactate dehydrogenase and alkaline phosphatase in different histological grades of head and neck squamous cell carcinoma and premalignant lesions.J Cancer Res Ther2018 Jul-SepBhattacharjee Adoi: 10.4103/0973-1482.172718.
29970686Clinical evaluation of potential usefulness of serum lactate dehydrogenase level in follow-up of small cell lung cancer.J Cancer Res Ther2018 JunChen Cdoi: 10.4103/0973-1482.168994.
30015851miR199a3p/Sp1/LDHA axis controls aerobic glycolysis in testicular tumor cells.Int J Mol Med2018 OctZhou Sdoi: 10.3892/ijmm.2018.3771
29321091The Downregulation of miR-200c Promotes Lactate Dehydrogenase A Expression and Non-Small Cell Lung Cancer Progression.Oncol Res2018 Aug 23Lei Wdoi: 10.3727/096504018X15151486241153
28516914Adenylate kinase hCINAP determines self-renewal of colorectal cancer stem cells by facilitating LDHA phosphorylation.Nat Commun2017 May 18Ji Ydoi: 10.1038/ncomms15308.
29569755LDHA is a direct target of miR-30d-5p and contributes to aggressive progression of gallbladder carcinoma.Mol Carcinog2018 JunHe Ydoi: 10.1002/mc.22799

Differential Expression

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
ACCchr11184073683'UTRnovel0.67
ACCchr1118400932Missense_MutationnovelV114M0.58
BRCAchr11183965895'UTRnovel0.28
BRCAchr1118400953Missense_Mutationrs746460566I121V0.1
BRCAchr1118407213Missense_MutationNAE311K0.28
BRCAchr11184076353'UTRnovel0.12
BRCAchr1118396924Missense_MutationNAV28I0.2
BRCAchr11184074273'UTRnovel0.2
CESCchr1118400887Missense_Mutationrs763532603R99C0.39
CESCchr11184075293'UTRnovel0.55
CESCchr11184075683'UTRnovel0.41
CESCchr11183965195'UTRnovel0.26
COADchr1118396895Frame_Shift_DelNAQ20Rfs*210.41
COADchr1118402943Frame_Shift_DelNAE176Kfs*80.28
COADchr1118399466Silentrs200075826I54I0.38
COADchr1118403779Frame_Shift_InsnovelW227Tfs*160.06
COADchr11184074953'UTRnovel0.21
COADchr11184074973'UTRnovel0.12
GBMchr1118407154Missense_MutationnovelV291A0.45
GBMchr1118407171Nonsense_MutationNAQ297*0.73
GBMchr1118399505Missense_MutationnovelH67Q0.1
HNSCchr11184073163'UTRnovel0.17
HNSCchr1118400908Missense_MutationnovelR106C0.08
LAMLchr11184074243'UTRnovel0.12
LUADchr1118396896SilentNAT18T0.12
LUADchr1118403807Nonsense_MutationnovelE236*0.1
LUADchr1118402945Missense_MutationnovelG175V0.21
LUADchr1118407243Missense_Mutationrs200019907D321N0.19
LUADchr1118405540Frame_Shift_DelnovelR268Gfs*90.08
LUADchr1118399543Missense_MutationNAG80V0.17
LUADchr1118402980Missense_MutationnovelG187W0.13
OVchr1118405555In_Frame_InsnovelV273delinsAQERNTI0.07
OVchr1118403807Missense_MutationNAE236Q0.16
SKCMchr1118396891Frame_Shift_InsnovelT18Rfs*240.44
SKCMchr1118403747Missense_MutationNAP216S0.09
SKCMchr1118407191In_Frame_DelnovelV304_S310del0.29
SKCMchr1118399518Missense_MutationNAL72F0.5
SKCMchr1118403790Missense_MutationNAV230A0.47
SKCMchr11184073533'UTRnovel0.38
SKCMchr1118402932Missense_Mutationrs752156024R171C0.29
SKCMchr1118403807Nonsense_MutationnovelE236*0.32
SKCMchr1118407156Missense_MutationnovelP292S0.11
STADchr1118405503Frame_Shift_DelnovelV256Sfs*120.21
STADchr1118402890Missense_MutationnovelR157C0.08
STADchr1118400950Missense_MutationNAI120L0.25
STADchr1118399467Missense_Mutationrs144856598E55K0.33
STADchr1118399494Missense_MutationnovelD64N0.11
STADchr1118402995Missense_MutationnovelE192K0.14
STADchr1118407173SilentnovelQ297Q0.32
STADchr11184073693'UTRrs5626949070.24
STADchr1118396895Frame_Shift_DelNAQ20Rfs*210.38
STADchr1118396895Frame_Shift_DelNAQ20Rfs*210.38
STADchr1118399546Missense_MutationnovelK81R0.24
STADchr1118407200SilentNAV306V0.35
STADchr1118402933Missense_Mutationrs760172008R171H0.39
THCAchr1118399512Missense_MutationNAL70V0.4
THCAchr1118405493Missense_MutationNAI252T0.06
UCECchr1118399455Missense_Mutationrs758645316V51I0.35
UCECchr1118407163Frame_Shift_DelnovelL295Wfs*100.44
UCECchr1118405507Missense_MutationNAA257T0.39
UCECchr1118403014Splice_SiteNAX198_splice0.12
UCECchr1118407226Missense_Mutationrs140090654R315H0.06
UCECchr1118396863SilentNAQ7Q0.37
UCECchr1118407226Missense_Mutationrs140090654R315H0.41
UCECchr1118400878Missense_MutationnovelA96T0.46
UCECchr1118396965Missense_MutationnovelM41I0.11
UCECchr11184073703'UTRrs2004416390.19
UCECchr11183965805'UTRnovel0.32
UCECchr1118396918Missense_MutationNAV26L0.1
UCECchr1118400884Missense_MutationnovelA98S0.33
UCECchr11184074273'UTRnovel0.42
UCECchr1118399467Missense_Mutationrs144856598E55K0.53
UCECchr11184075493'UTRnovel0.36
UCECchr11184075923'UTRrs2000791570.5
UCECchr1118396847Missense_MutationnovelA2G0.18
UCECchr11184072833'UTRnovel0.33
UCECchr11184076423'UTRnovel0.48
UCECchr11183964115'UTRnovel0.38
UCECchr1118396908Missense_MutationNAK22N0.25
UCECchr11184073843'UTRnovel0.41
UCECchr1118396954Missense_MutationNAS38G0.24
UCECchr11184073293'UTRNA0.14
UCECchr11184074843'UTRnovel0.22
UCECchr1118399534Missense_MutationnovelI77T0.06
UCECchr11183965805'UTRnovel0.49
UCECchr11184073393'UTRrs7717128150.4

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
CESCDEL0.27460.02701
ESCAAMP0.14130.018342
PCPGAMP0.03090.23196
TGCTDEL0.54670.21504

Survival Analysis
CancerP-value Q-value
KIRC0.043

Kaplan-Meier Survival Analysis

ACC0.0053

Kaplan-Meier Survival Analysis

HNSC0.0022

Kaplan-Meier Survival Analysis

PRAD0.034

Kaplan-Meier Survival Analysis

KIRP0.018

Kaplan-Meier Survival Analysis

PAAD0.0001

Kaplan-Meier Survival Analysis

BLCA0.016

Kaplan-Meier Survival Analysis

CESC0.00039

Kaplan-Meier Survival Analysis

READ0.049

Kaplan-Meier Survival Analysis

KICH0.00096

Kaplan-Meier Survival Analysis

GBM0.0018

Kaplan-Meier Survival Analysis

LIHC0.0001

Kaplan-Meier Survival Analysis

LGG0.0001

Kaplan-Meier Survival Analysis

LUAD0.00012

Kaplan-Meier Survival Analysis

OV0.027

Kaplan-Meier Survival Analysis

Drugs

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Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBPome
  • Literatures
  • Expression
  • Transcripts
  • Gene Model
  • Pathways
  • Phenotypes
  • GWAS
  • PPI
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000134333 (Gene tree)
Gene ID
3939
Gene Symbol
LDHA
Alias
N
Full Name
lactate dehydrogenase A
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Plus strand
Length
14,038 bases
Position
chr11:18,394,388-18,408,425
Accession
6535
RBP type
non-canonical RBP
Summary
The protein encoded by this gene catalyzes the conversion of L-lactate and NAD to pyruvate and NADH in the final step of anaerobic glycolysis. The protein is found predominantly in muscle tissue and belongs to the lactate dehydrogenase family. Mutations in this gene have been linked to exertional myoglobinuria. Multiple transcript variants encoding different isoforms have been found for this gene. The human genome contains several non-transcribed pseudogenes of this gene. [provided by RefSeq, Sep 2008]
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & HEK2932019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & HEK2932018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
29431736Capturing the interactome of newly transcribed RNAPolyT-RICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
29431736Capturing the interactome of newly transcribed RNARICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & Hela2018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & MCF10A2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & U2OS2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
30136864Gordon H. Dixon's trace in my personal career and the quantic jump experienced in regulatory information.Syst Biol Reprod Med2018 DecMezquita-Pla Jdoi: 10.1080/19396368.2018.1503752
23237800Galloflavin prevents the binding of lactate dehydrogenase A to single stranded DNA and inhibits RNA synthesis in cultured cells.Biochem Biophys Res Commun2013 Jan 11Fiume Ldoi: 10.1016/j.bbrc.2012.12.013
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000430553LDHA-2061310-ENSP00000406172274 (aa)-P00338
ENST00000396222LDHA-2041766-ENSP00000379524274 (aa)-P00338
ENST00000375710LDHA-2022169--- (aa)--
ENST00000542179LDHA-2201288-ENSP00000445331332 (aa)-P00338
ENST00000494573LDHA-2111154--- (aa)--
ENST00000478970LDHA-209732-ENSP00000441241144 (aa)-F5GYU2
ENST00000540430LDHA-2182305-ENSP00000445175361 (aa)-P00338
ENST00000422447LDHA-2052416-ENSP00000395337332 (aa)-P00338
ENST00000535451LDHA-213465-ENSP0000044429272 (aa)-F5GZQ4
ENST00000539814LDHA-217556-ENSP0000044297994 (aa)-F5H6W8
ENST00000469976LDHA-208656--- (aa)--
ENST00000545467LDHA-224570-ENSP0000044354542 (aa)-F5H8H6
ENST00000460405LDHA-207680--- (aa)--
ENST00000495052LDHA-212682-ENSP00000446415114 (aa)-F5GXH2
ENST00000379412LDHA-2031922-ENSP00000368722332 (aa)-P00338
ENST00000541097LDHA-219582-ENSP0000044336289 (aa)-F5H5J4
ENST00000543445LDHA-221576-ENSP00000440161156 (aa)-F5GXY2
ENST00000537296LDHA-2151511--- (aa)--
ENST00000536528LDHA-214516-ENSP0000044105845 (aa)-F5GXC7
ENST00000227157LDHA-2011887-ENSP00000227157241 (aa)-P00338
ENST00000625635LDHA-225141-ENSP0000048624946 (aa)-F5GXU1
ENST00000538451LDHA-2161345--- (aa)--
ENST00000486690LDHA-210664-ENSP0000044169945 (aa)-F5GWW2
ENST00000543695LDHA-222554-ENSP0000044036846 (aa)-F5GXU1
ENST00000545215LDHA-2231340-ENSP0000044263745 (aa)-F5GWW2
Gene Model
Click here to download ENSG00000134333's gene model file
Pathways
Pathway IDPathway NameSource
hsa00010Glycolysis / GluconeogenesisKEGG
hsa00270Cysteine and methionine metabolismKEGG
hsa00620Pyruvate metabolismKEGG
hsa00640Propanoate metabolismKEGG
hsa01100Metabolic pathwaysKEGG
hsa04066HIF-1 signaling pathwayKEGG
hsa04922Glucagon signaling pathwayKEGG
hsa05230Central carbon metabolism in cancerKEGG
Phenotypes
ensgIDTraitpValuePubmed ID
ENSG00000134333Serum Amyloid A Protein4E-2221124955
GWAS
ensgIDSNPChromosomePositionSNP-risk TraitPubmedID95% CIOr or BEAT EFO ID
ENSG00000134333rs28965261118398259GAmyloid A serum levels21124955[0.17-0.27] unit increase0.221EFO_0004728
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000134333's network

* RBP PPI network refers to all genes directly bind to RBP
Orthologs identified by RBPome
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000134333LDHA10095.833ENSMUSG00000063229Ldha10095.588Mus_musculus
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0001666response to hypoxia-IEAProcess
GO:0004459L-lactate dehydrogenase activity1953713.NASFunction
GO:0005515protein binding23523103.IPIFunction
GO:0005634nucleus21630459.HDAComponent
GO:0005829cytosol-TASComponent
GO:0006089lactate metabolic process-IEAProcess
GO:0006090pyruvate metabolic process-TASProcess
GO:0006096glycolytic process1953713.NASProcess
GO:0007584response to nutrient-IEAProcess
GO:0009749response to glucose-IEAProcess
GO:0016020membrane19946888.HDAComponent
GO:0019674NAD metabolic process-IEAProcess
GO:0019900kinase binding-IEAFunction
GO:0042542response to hydrogen peroxide-IEAProcess
GO:0042802identical protein binding-IEAFunction
GO:0043065positive regulation of apoptotic process-IEAProcess
GO:0043627response to estrogen-IEAProcess
GO:0045296cadherin binding25468996.HDAFunction
GO:0048569post-embryonic animal organ development-IEAProcess
GO:0051287NAD binding-IEAFunction
GO:0051591response to cAMP-IEAProcess
GO:0055114oxidation-reduction process-IEAProcess
GO:0070062extracellular exosome11487543.19056867.20458337.23533145.HDAComponent
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