EuRBPDB

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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
20573375Mutational and expressional analysis of RFC3, a clamp loader in DNA replication, in gastric and colorectal cancers.Hum Pathol2010 OctKim YRdoi: 10.1016/j.humpath.2010.03.006
26464638ShRNA-mediated silencing of the RFC3 gene suppress ovarian tumor cells proliferation.Int J Clin Exp Pathol2015 Aug 1Shen H-
229495219-Cis-retinoic acid induces growth inhibition in retinoid-sensitive breast cancer and sea urchin embryonic cells via retinoid X receptor α and replication factor C3.Mol Endocrinol2012 NovMaeng Sdoi: 10.1210/me.2012-1104

Differential Expression

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
BLCAchr13338181355'UTRnovel0.13
BLCAchr1333836114Nonsense_MutationnovelS297*0.22
BRCAchr1333825839Missense_Mutationrs758867827V115A0.06
BRCAchr13338363633'UTRnovel0.34
BRCAchr1333966119Missense_MutationnovelI304M0.06
CESCchr1333830731SilentnovelL196L0.29
CESCchr1333836122SilentnovelL300L0.49
CESCchr1333821153Missense_MutationNAH37Y0.18
COADchr13338364023'UTRrs10539600.33
COADchr13338363953'UTRnovel0.31
COADchr13339661803'UTRnovel0.34
COADchr1333829867SilentNAT141T0.4
COADchr1333831346SilentnovelT267T0.15
COADchr13338363683'UTRnovel0.19
COADchr1333821255Nonsense_MutationnovelH71Lfs*30.07
ESCAchr1333836289Missense_MutationnovelM355I0.07
GBMchr1333830728Missense_MutationnovelV195L0.16
HNSCchr1333825844Frame_Shift_InsnovelS118Ifs*50.24
HNSCchr13338363243'UTRnovel0.3
HNSCchr13338181355'UTRrs3680665650.42
KIRCchr13338363793'UTRnovel0.28
KIRPchr13339663263'UTRnovel0.5
LAMLchr1333835148Splice_RegionNAR270R0.33
LAMLchr1333821220Missense_MutationnovelL59P0.04
LAMLchr1333829946Missense_MutationNAT168P0.29
LUADchr1333829873SilentnovelD143D0.86
LUADchr1333830806Nonsense_MutationNAR221*0.21
LUADchr1333830804Missense_MutationNAC220F0.17
LUSCchr1333830761Missense_MutationnovelN206Y0.07
LUSCchr1333966125Nonstop_Mutationnovel*306Cext*190.57
LUSCchr1333829967Missense_MutationnovelI175V0.43
LUSCchr13339662113'UTRnovel0.29
LUSCchr13338181485'UTRrs7774269910.11
LUSCchr1333831255Splice_SitenovelX237_splice0.12
OVchr13338181275'UTRnovel0.46
PRADchr1333825854Missense_MutationnovelQ120P0.25
PRADchr1333818219Missense_Mutationrs140507898G14E0.2
PRADchr1333829985Missense_MutationnovelA181T0.34
READchr13338363143'UTRnovel0.24
SKCMchr1333836265Missense_MutationnovelM347I0.9
SKCMchr1333836266Missense_MutationnovelE348K0.9
SKCMchr1333831283SilentnovelI246I0.45
SKCMchr1333835161Missense_Mutationrs761845498R275C0.16
SKCMchr13338363363'UTRnovel0.35
SKCMchr13339661693'UTRnovel0.64
SKCMchr1333825881Missense_MutationnovelF129C0.2
STADchr1333835209Missense_MutationnovelI291V0.11
STADchr1333829993SilentNAR183R0.19
STADchr1333835161Missense_Mutationrs761845498R275C0.35
STADchr13338181635'UTRnovel0.48
STADchr1333836227Missense_MutationNAF335L0.19
STADchr1333829893Missense_MutationNAR150K0.16
UCECchr13338180825'UTRnovel0.67
UCECchr1333818172Missense_Mutationnovel0.05
UCECchr1333821196Missense_MutationNAR51I0.29
UCECchr13338365203'UTRnovel0.31
UCECchr13338363313'UTRnovel0.35
UCECchr1333830006Missense_MutationnovelS188R0.35
UCECchr1333829970Frame_Shift_DelNAR176Lfs*210.28
UCECchr1333823926Frame_Shift_Delrs753959887I82Lfs*250.46
UCECchr1333836245Missense_MutationNAA341T0.4
UCECchr1333829992Missense_Mutationrs761230186R183H0.38
UCECchr1333830728Missense_Mutationrs41553716V195M0.35
UCECchr1333836167Missense_MutationNAA315S0.31
UCECchr13338180825'UTRnovel0.31
UCECchr1333835162Missense_Mutationrs751166752R275H0.21
UCECchr1333823926Frame_Shift_DelNAK81Nfs*20.29
UCECchr1333821254SilentnovelE70E0.44
UCECchr1333831278Nonsense_MutationnovelE245*0.12
UCECchr1333836186Missense_MutationnovelR321H0.43
UCECchr1333821168Missense_Mutationrs769043955G42R0.4
UCECchr13338180825'UTRnovel0.39
UCECchr1333830728Missense_Mutationrs41553716V195M0.23
UCECchr1333836181SilentnovelE319E0.46
UCECchr1333829850Nonsense_MutationnovelE136*0.57
UCECchr1333830745SilentnovelC200C0.08
UCECchr1333823926Frame_Shift_Delrs753959887I82Lfs*250.39
UCECchr13339663553'UTRnovel0.22
UCECchr13339663563'UTRnovel0.22
UCECchr1333830017Splice_RegionnovelD191D0.37
UCECchr1333821191Missense_MutationNAK49N0.41
UCECchr1333823971Missense_MutationnovelE94K0.43

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
KIRCDEL0.11930.031318
MESODEL0.41380.0010209
STADAMP0.31070.01734

Survival Analysis
CancerP-value Q-value
THYM0.0027

Kaplan-Meier Survival Analysis

KIRC0.0041

Kaplan-Meier Survival Analysis

STAD0.05

Kaplan-Meier Survival Analysis

SARC0.029

Kaplan-Meier Survival Analysis

MESO0.0024

Kaplan-Meier Survival Analysis

ACC0.0001

Kaplan-Meier Survival Analysis

HNSC0.021

Kaplan-Meier Survival Analysis

KIRP0.00016

Kaplan-Meier Survival Analysis

KICH0.012

Kaplan-Meier Survival Analysis

LGG0.0002

Kaplan-Meier Survival Analysis

LUAD0.023

Kaplan-Meier Survival Analysis

Drugs

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Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBPome
  • Expression
  • Transcripts
  • Gene Model
  • Pathways
  • Phenotypes
  • GWAS
  • PPI
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000133119 (Gene tree)
Gene ID
5983
Gene Symbol
RFC3
Alias
RFC38|MGC5276
Full Name
replication factor C subunit 3
Gene Type
protein_coding
Species
Homo_sapiens
Status
putative
Strand
Plus strand
Length
155,898 bases
Position
chr13:33,818,049-33,973,946
Accession
9971
RBP type
non-canonical RBP
Summary
The elongation of primed DNA templates by DNA polymerase delta and DNA polymerase epsilon requires the accessory proteins proliferating cell nuclear antigen (PCNA) and replication factor C (RFC). RFC, also named activator 1, is a protein complex consisting of five distinct subunits of 140, 40, 38, 37, and 36 kDa. This gene encodes the 38 kDa subunit. This subunit is essential for the interaction between the 140 kDa subunit and the core complex that consists of the 36, 37, and 40 kDa subunits. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
29431736Capturing the interactome of newly transcribed RNAPolyT-RICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
29431736Capturing the interactome of newly transcribed RNARICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000434425RFC3-2021461XM_011535172ENSP00000401001305 (aa)XP_011533474P40938
ENST00000380071RFC3-2012402XM_011535174ENSP00000369411356 (aa)XP_011533476P40938
ENST00000616236RFC3-203612-ENSP00000484747103 (aa)-A0A087X270
Gene Model
Click here to download ENSG00000133119's gene model file
Pathways
Pathway IDPathway NameSource
hsa03030DNA replicationKEGG
hsa03420Nucleotide excision repairKEGG
hsa03430Mismatch repairKEGG
Phenotypes
ensgIDTraitpValuePubmed ID
ENSG00000133119Body Weights and Measures5.11969458985379E-617903300
ENSG00000133119Body Weights and Measures3.49703759575645E-617903300
GWAS
ensgIDSNPChromosomePositionSNP-risk TraitPubmedID95% CIOr or BEAT EFO ID
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000133119's network

* RBP PPI network refers to all genes directly bind to RBP
Orthologs identified by RBPome
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000133119RFC310097.191ENSMUSG00000033970Rfc310097.191Mus_musculus
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0000731DNA synthesis involved in DNA repair9488738.TASProcess
GO:0003677DNA binding9488738.IDAFunction
GO:0003689DNA clamp loader activity21873635.IBAFunction
GO:0003689DNA clamp loader activity12930902.IDAFunction
GO:0003689DNA clamp loader activity9488738.TASFunction
GO:0005515protein binding9488738.IPIFunction
GO:0005634nucleus21873635.IBAComponent
GO:0005654nucleoplasm-TASComponent
GO:0005663DNA replication factor C complex21873635.IBAComponent
GO:0005663DNA replication factor C complex9488738.IDAComponent
GO:0005663DNA replication factor C complex7774928.TASComponent
GO:0006260DNA replication9488738.IDAProcess
GO:0006260DNA replication-TASProcess
GO:0006261DNA-dependent DNA replication21873635.IBAProcess
GO:0006271DNA strand elongation involved in DNA replication7774928.TASProcess
GO:0006283transcription-coupled nucleotide-excision repair-TASProcess
GO:0006296nucleotide-excision repair, DNA incision, 5'-to lesion-TASProcess
GO:0006297nucleotide-excision repair, DNA gap filling-TASProcess
GO:0016887ATPase activity9488738.IDAFunction
GO:0019985translesion synthesis-TASProcess
GO:0031390Ctf18 RFC-like complex12930902.IDAComponent
GO:0032201telomere maintenance via semi-conservative replication-TASProcess
GO:0033683nucleotide-excision repair, DNA incision-TASProcess
GO:0042276error-prone translesion synthesis-TASProcess
GO:0042769DNA damage response, detection of DNA damage-TASProcess
GO:0043142single-stranded DNA-dependent ATPase activity12930902.IDAFunction
GO:0046683response to organophosphorus16079077.IEPProcess
GO:0070987error-free translesion synthesis-TASProcess
GO:1900264positive regulation of DNA-directed DNA polymerase activity12930902.IDAProcess
GO:1901796regulation of signal transduction by p53 class mediator-TASProcess
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