EuRBPDB

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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
22339894Opposing function of MYBBP1A in proliferation and migration of head and neck squamous cell carcinoma cells.BMC Cancer2012 Feb 17Acua Sanhueza GAdoi: 10.1186/1471-2407-12-72.
18059336Ets-2 and p160 proteins collaborate to regulate c-Myc in endocrine resistant breast cancer.Oncogene2008 May 8Al-azawi D-
23388179MYBBP1A suppresses breast cancer tumorigenesis by enhancing the p53 dependent anoikis.BMC Cancer2013 Feb 7Akaogi Kdoi: 10.1186/1471-2407-13-65.

Differential Expression

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
ACCchr174550110Frame_Shift_DelnovelV423Lfs*260.26
ACCchr174550111Missense_MutationnovelL422F0.26
BLCAchr174554065Missense_MutationNAN136S0.85
BLCAchr174541810Missense_MutationNAG1057C0.23
BLCAchr174539634SilentnovelQ1256Q0.12
BLCAchr174540479SilentnovelL1101L0.13
BLCAchr174548172Silentrs752366577F565F0.38
BLCAchr174550204SilentnovelF391F0.13
BLCAchr174545271SilentnovelL716L0.9
BLCAchr174554945Missense_Mutationrs746267976M70I0.54
BLCAchr174550194Missense_Mutationrs749510484V395M0.15
BLCAchr174552621Silentrs377058397S189S0.25
BLCAchr174555280SilentnovelA15A0.46
BLCAchr174543012SilentnovelL931L0.46
BRCAchr174551918Missense_Mutationrs141257590V329M0.38
BRCAchr174549364SilentNAE466E0.13
BRCAchr174544894Missense_MutationNAE780K0.32
BRCAchr174548295SilentNAL524L0.31
BRCAchr174545048Missense_MutationNAV763A0.4
CESCchr174543090Silentrs777438698E905E0.43
CESCchr174545853Silentrs376866252K638K0.22
CESCchr174551993Silentrs767594039L304L0.2
CESCchr174548050Nonsense_MutationnovelQ578*0.37
CESCchr174551974Missense_MutationnovelG310D0.41
CESCchr174540365Missense_MutationNAM1139I0.21
CESCchr174552487Missense_MutationNAG234E0.55
COADchr174554203Missense_MutationNAV124L0.23
COADchr174543059Missense_Mutationrs145275737D916N0.28
COADchr174550270SilentnovelR369R0.25
COADchr174554194Splice_SitenovelX126_splice0.31
COADchr174555145Nonsense_MutationnovelY60*0.19
COADchr174539880Missense_MutationnovelF1174L0.2
COADchr174554198Missense_MutationnovelK125N0.44
COADchr174541966Intronnovel0.31
COADchr174543131Missense_Mutationrs562871359D892N0.79
COADchr1745553725'UTRnovel0.67
COADchr174543118Missense_Mutationrs181039881R896H0.22
COADchr174548580Silentrs199791918P500P0.09
COADchr174541558Missense_Mutationrs573540438R1068C0.3
COADchr174543047Missense_Mutationrs747847889A920T0.28
COADchr174541529Silentrs757893508A1077A0.18
COADchr174541557Missense_Mutationrs199584868R1068H0.2
COADchr174545276Missense_Mutationrs561399448R715W0.17
COADchr174545156Missense_Mutationrs755542622E727G0.19
COADchr174541967Intronnovel0.38
COADchr174553839Missense_Mutationrs200728167R178W0.28
COADchr174543113Missense_MutationNAG898W0.45
COADchr174541803Missense_MutationnovelV1059A0.43
COADchr174548192Missense_Mutationrs750166636V559M0.12
COADchr174555146Missense_MutationnovelY60C0.28
COADchr174545671Missense_Mutationrs754670204R671Q0.47
ESCAchr174542326Intronnovel0.6
ESCAchr174554086Frame_Shift_InsnovelL129Pfs*860.17
GBMchr174552262SilentnovelS256S0.45
GBMchr174550124Missense_MutationnovelD418V0.09
GBMchr174552513SilentnovelV225V0.27
GBMchr174552561SilentnovelL209L0.14
GBMchr174552553Missense_MutationnovelP212H0.23
GBMchr174554030Missense_MutationnovelR148G0.26
GBMchr174541848Missense_MutationnovelR1044K0.32
GBMchr174545167Silentrs148999986S723S0.12
GBMchr174551970Silentrs149464957A311A0.53
GBMchr174545847Missense_MutationNAI640M0.65
GBMchr174539741Missense_MutationNAP1221T0.11
GBMchr174552557Missense_MutationnovelS211A0.48
HNSCchr174543045SilentnovelA920A0.23
HNSCchr174553894SilentnovelS159S0.16
HNSCchr174540394Missense_Mutationrs138042708R1130C0.06
HNSCchr174542502Missense_Mutationrs765383465V1017I0.22
HNSCchr174539520SilentnovelA1294A0.19
HNSCchr174539719Missense_MutationnovelP1228R0.26
HNSCchr174544657Intronnovel0.18
KIRCchr174555198Frame_Shift_InsnovelA43Cfs*40.26
KIRCchr1745389443'UTRnovel0.06
KIRPchr174542472Missense_Mutationrs200492249R1027S0.33
KIRPchr174542620Missense_Mutationrs779629446H1005R0.61
LAMLchr174539423Missense_MutationnovelK1327E0.07
LGGchr174542617Missense_Mutationrs567715978P1006L0.16
LGGchr1745393163'UTRnovel0.56
LIHCchr174543048Silentrs769485013T919T0.09
LIHCchr174539875Missense_MutationnovelP1176Q0.08
LIHCchr174539466SilentNAL1312L0.37
LIHCchr174548205SilentnovelN554N0.25
LUADchr174539812Missense_Mutationrs776740818P1197L0.3
LUADchr174548270Missense_MutationnovelG533C0.14
LUADchr174543152Missense_Mutationrs148844016R885C0.48
LUADchr1745389853'UTRnovel0.12
LUADchr174548167Missense_Mutationrs139169505A567V0.59
LUADchr174543048Silentrs769485013T919T0.14
LUADchr174545318Missense_MutationnovelE701Q0.13
LUADchr174550309SilentnovelV356V0.14
LUSCchr174549424SilentnovelF446F0.5
LUSCchr174554926Missense_MutationnovelL77V0.47
LUSCchr174542655SilentnovelL993L0.44
LUSCchr174541542Missense_Mutationrs773128498A1073V0.16
LUSCchr174545750Missense_MutationnovelP645S0.41
LUSCchr174552564Missense_MutationnovelI208M0.67
LUSCchr174539840Missense_MutationNAD1188Y0.52
LUSCchr174542666Missense_MutationNAN990Y0.44
LUSCchr174540467SilentnovelL1105L0.54
LUSCchr174548166SilentnovelA567A0.36
OVchr174551991SilentnovelL304L0.15
OVchr174539724SilentNAG1226G0.31
OVchr1745392373'UTRnovel0.25
OVchr174551959Missense_MutationnovelL315Q0.2
OVchr174550194Missense_MutationNAV395L0.5
OVchr174539620Missense_MutationnovelV1261A0.06
OVchr174552138Missense_MutationnovelF298V0.13
OVchr174552609Missense_MutationNAL193F0.17
OVchr174539968Splice_SitenovelX1145_splice0.07
OVchr174540437SilentnovelQ1115Q0.33
PAADchr174542668Missense_MutationnovelR989H0.16
PAADchr174545718SilentnovelL655L0.22
PAADchr174552267Missense_Mutationrs770006947A255T0.14
PAADchr174555266Missense_MutationnovelA20V0.54
PRADchr174553817Missense_Mutationrs771031263L185H0.78
PRADchr174548193Silentrs141617248N558N0.43
PRADchr174551969Missense_MutationnovelA312T0.42
SARCchr174544557SilentnovelR857R0.8
SARCchr174545101Missense_MutationnovelE745D0.14
SKCMchr174540473SilentNAL1103L0.51
SKCMchr174541933Intronnovel0.48
SKCMchr174542511Missense_MutationNAP1014S0.46
SKCMchr174552213Missense_Mutationrs200095188R273C0.63
SKCMchr174539562SilentNAA1280A0.15
SKCMchr174541506Missense_Mutationrs767187903S1085F0.1
SKCMchr174539455Missense_MutationNAA1316V0.54
SKCMchr174539928Silentrs764958122P1158P0.36
SKCMchr174539929Missense_MutationnovelP1158H0.36
SKCMchr174554906SilentNAV83V0.5
SKCMchr174552476SilentNAL238L0.25
SKCMchr174542648Missense_MutationNAP996S0.67
SKCMchr1745390963'UTRnovel0.63
SKCMchr174554255SilentNAL106L0.16
SKCMchr174551985SilentNAF306F0.26
SKCMchr174545635Missense_Mutationrs748400049P683L0.14
SKCMchr174552247SilentNAD261D0.32
SKCMchr174553814Missense_MutationNAS186F0.16
SKCMchr174542710Missense_MutationNAT975S0.15
SKCMchr174550066In_Frame_InsnovelS437dup0.35
SKCMchr174548205Missense_MutationNAN554K0.27
STADchr174543064Missense_MutationNAQ914P0.22
STADchr174545144Missense_MutationNAS731N0.12
STADchr174541526In_Frame_DelnovelT1075_Q1078del0.21
STADchr174548290Missense_Mutationrs371564259T526M0.36
STADchr174542975Missense_Mutationrs772040831H944Y0.16
STADchr174539551Missense_MutationNAK1284R0.28
STADchr174539666Missense_MutationNAA1246T0.22
STADchr174545278Missense_Mutationrs765199525R714Q0.37
STADchr174548222Missense_MutationnovelA549T0.38
STADchr174554224Nonsense_MutationnovelE117*0.45
STADchr174548256SilentNAG537G0.41
STADchr174554210SilentNAL121L0.22
STADchr1745393803'UTRnovel0.35
STADchr1745389213'UTRrs7581173270.19
STADchr174544908Frame_Shift_DelnovelS775*0.29
STADchr174554199Missense_Mutationrs745824142K125R0.07
STADchr174539694Silentrs138002559G1236G0.4
STADchr174551963Missense_MutationNAP314A0.19
STADchr174545635Missense_Mutationrs748400049P683L0.33
STADchr174552596Missense_MutationNAP198S0.29
STADchr174550272Missense_Mutationrs533085700R369W0.47
STADchr1745390363'UTRnovel0.54
THCAchr174539919SilentNAT1161T0.1
THYMchr174540434SilentnovelQ1116Q0.09
UCECchr1745389213'UTRrs7581173270.34
UCECchr174555211Missense_MutationNAF38L0.36
UCECchr174550146Missense_Mutationrs763712203R411W0.25
UCECchr174548222Missense_MutationnovelA549T0.31
UCECchr174552471Missense_MutationNAF239L0.5
UCECchr174544504Missense_Mutationrs200285589T875M0.28
UCECchr174545911Missense_MutationnovelD619G0.4
UCECchr174549403SilentnovelI453I0.5
UCECchr174543012SilentnovelL931L0.52
UCECchr174545108Missense_MutationnovelS743I0.04
UCECchr174554272Nonsense_MutationnovelQ101*0.25
UCECchr1745390363'UTRnovel0.54
UCECchr174541858Missense_Mutationrs758091815R1041W0.43
UCECchr174551984Missense_Mutationrs145701504R307C0.22
UCECchr174554049SilentNAL141L0.29
UCECchr174553838Missense_Mutationrs201294033R178Q0.2
UCECchr1745390363'UTRnovel0.25
UCECchr174542651Missense_MutationNAV995I0.37
UCECchr174539868Silentrs373698621T1178T0.5
UCECchr174540411Missense_Mutationrs530548606H1124R0.38
UCECchr174544592SilentnovelL846L0.38
UCECchr174542661SilentnovelS991S0.28
UCECchr174544651Splice_Regionnovel1
UCECchr1745393673'UTRrs7698290370.36
UCECchr174541558Missense_Mutationrs573540438R1068C0.36
UCECchr174545870Missense_Mutationrs140612186R633C0.38
UCECchr174550195Silentrs771827811V394V0.37
UCECchr174553858SilentnovelN171N0.36
UCECchr174539598SilentNAP1268P0.48
UCECchr174552286SilentnovelV248V0.55
UCECchr174542627Missense_MutationnovelS1003P0.11
UCECchr174548186Missense_MutationnovelT561A0.46
UCECchr174548235SilentNAH544H0.1
UCECchr174545901SilentnovelT622T0.09
UCECchr174541967Intronnovel0.67
UCECchr174552471Missense_MutationNAF239L0.35
UCECchr174555211Missense_MutationNAF38L0.34
UCECchr1745390163'UTRnovel0.18
UCECchr174539564Missense_MutationnovelA1280T0.31
UCECchr174539942Missense_MutationnovelA1154T0.28
UCECchr174539460SilentnovelS1314S0.49
UCECchr174544498Missense_Mutationrs368435100R877H0.38
UCECchr174544498Missense_Mutationrs368435100R877H0.35
UCECchr174548151SilentnovelA572A0.48
UCECchr1745389423'UTRnovel0.29
UCECchr174544892SilentnovelE780E0.47
UCECchr174539810Missense_MutationNAA1198T0.45
UCECchr174551967SilentNAA312A0.42
UCECchr174540424Nonsense_Mutationrs199926550Q1120*0.34
UCECchr174539551Missense_MutationNAK1284R0.38
UCECchr174539784Frame_Shift_DelnovelS1207Afs*550.36
UCECchr174555186Nonsense_Mutationrs758083465Q47*0.31
UCECchr174542503SilentnovelL1016L0.17
UCECchr174539629Missense_Mutationrs778149572P1258L0.24
UCECchr174552471Missense_MutationNAF239L0.38
UCECchr174543145Missense_Mutationrs373020054R887Q0.08
UCECchr174554082Missense_MutationnovelR130S0.06
UCECchr174550134Missense_MutationnovelL415I0.36
UCECchr1745390003'UTRnovel0.23
UCECchr1745393783'UTRnovel0.18
UCECchr174541841SilentnovelC1046C0.18
UCECchr174550098Missense_MutationnovelT427A0.31
UCECchr174541950Intronnovel0.51
UCECchr174545635Missense_Mutationrs748400049P683L0.34
UCECchr174554929Missense_MutationnovelR76C0.34

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
DLBCDEL0.20830.18166
LAMLDEL0.07330.12511
LIHCDEL0.54593.9592e-10
THCADEL0.0160.221

Survival Analysis
CancerP-value Q-value
KIRC0.0001

Kaplan-Meier Survival Analysis

SARC0.00058

Kaplan-Meier Survival Analysis

ACC0.033

Kaplan-Meier Survival Analysis

UCS0.028

Kaplan-Meier Survival Analysis

SKCM0.0021

Kaplan-Meier Survival Analysis

PRAD0.0076

Kaplan-Meier Survival Analysis

PAAD0.0016

Kaplan-Meier Survival Analysis

LIHC0.0068

Kaplan-Meier Survival Analysis

Drugs

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Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBPome
  • Literatures
  • Expression
  • Transcripts
  • Gene Model
  • PPI
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000132382 (Gene tree)
Gene ID
10514
Gene Symbol
MYBBP1A
Alias
P160|PAP2|FLJ37886|Pol5
Full Name
MYB binding protein 1a
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Minus strand
Length
16,736 bases
Position
chr17:4,538,896-4,555,631
Accession
7546
RBP type
non-canonical RBP
Summary
This gene encodes a nucleolar transcriptional regulator that was first identified by its ability to bind specifically to the Myb proto-oncogene protein. The encoded protein is thought to play a role in many cellular processes including response to nucleolar stress, tumor suppression and synthesis of ribosomal DNA. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
22681889The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts4SURIC & HEK2932012 MayBaltz AGDOI: 10.1016/j.molcel.2012.05.021
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & HEK2932019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & HEK2932018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
29431736Capturing the interactome of newly transcribed RNANascentRICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
29431736Capturing the interactome of newly transcribed RNAPolyT-RICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
29431736Capturing the interactome of newly transcribed RNARIC & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
29431736Capturing the interactome of newly transcribed RNARICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
22658674Insights into RNA biology from an atlas of mammalian mRNA-binding proteinsRIC & Hela2012 May 31Castello ADOI: 10.1016/j.cell.2012.04.031
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & Hela2018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & MCF10A2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & MCF72018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & U2OS2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
27453046Comprehensive Identification of RNA-Binding Domains in Human CellsRIC & Hela2016 Aug 18Castello ADOI: 10.1016/j.molcel.2016.06.029
30352994Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome captureRIC & Jurkat2018 Oct 23Perez-Perri JIDOI:10.1038/s41467-018-06557-8

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
16603771The WSTF-SNF2h chromatin remodeling complex interacts with several nuclear proteins in transcription.J Biol Chem2006 Jun 16Cavellan E-
22645127Myb-binding protein 1a (Mybbp1a) regulates levels and processing of pre-ribosomal RNA.J Biol Chem2012 Jul 13Hochstatter Jdoi: 10.1074/jbc.M111.303719
22649785The Roles of VHL-Dependent Ubiquitination in Signaling and Cancer.Front Oncol2012 Apr 12Zhang Qdoi: 10.3389/fonc.2012.00035
26044764Gradual reduction in rRNA transcription triggers p53 acetylation and apoptosis via MYBBP1A.Sci Rep2015 Jun 5Kumazawa Tdoi: 10.1038/srep10854.
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000571354MYBBP1A-204579--- (aa)--
ENST00000574547MYBBP1A-2111607--- (aa)--
ENST00000572759MYBBP1A-206588-ENSP0000046008769 (aa)-I3L311
ENST00000573723MYBBP1A-209613-ENSP00000459692204 (aa)-I3L2H8
ENST00000381556MYBBP1A-2024104-ENSP000003709681332 (aa)-Q9BQG0
ENST00000574934MYBBP1A-2121941--- (aa)--
ENST00000575662MYBBP1A-213687--- (aa)--
ENST00000254718MYBBP1A-2014807XM_011523616ENSP000002547181328 (aa)XP_011521918Q9BQG0
ENST00000573175MYBBP1A-208898--- (aa)--
ENST00000570986MYBBP1A-203982--- (aa)--
ENST00000573116MYBBP1A-2073795-ENSP000004589191252 (aa)-I3L1L3
ENST00000571368MYBBP1A-2051995--- (aa)--
ENST00000574167MYBBP1A-210746--- (aa)--
Gene Model
Click here to download ENSG00000132382's gene model file
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000132382's network

* RBP PPI network refers to all genes directly bind to RBP
Orthologs identified by RBPome
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000132382MYBBP1A9969.072ENSMUSG00000040463Mybbp1a9968.927Mus_musculus
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0001649osteoblast differentiation16210410.HDAProcess
GO:0003714transcription corepressor activity21873635.IBAFunction
GO:0003714transcription corepressor activity-ISSFunction
GO:0003723RNA binding22658674.22681889.HDAFunction
GO:0005634nucleus21471221.IDAComponent
GO:0005634nucleus-ISSComponent
GO:0005654nucleoplasm-TASComponent
GO:0005730nucleolus21873635.IBAComponent
GO:0005730nucleolus21471221.IDAComponent
GO:0005730nucleolus-ISSComponent
GO:0005737cytoplasm-ISSComponent
GO:0006355regulation of transcription, DNA-templated10644447.TASProcess
GO:0008134transcription factor binding-IEAFunction
GO:0016020membrane16210410.19946888.HDAComponent
GO:0022904respiratory electron transport chain-IEAProcess
GO:0032922circadian regulation of gene expression-ISSProcess
GO:0042149cellular response to glucose starvation21471221.IDAProcess
GO:0042254ribosome biogenesis-IEAProcess
GO:0042564NLS-dependent protein nuclear import complex-ISSComponent
GO:0043231intracellular membrane-bounded organelle-IDAComponent
GO:0043565sequence-specific DNA binding21873635.IBAFunction
GO:0045815positive regulation of gene expression, epigenetic-TASProcess
GO:0045892negative regulation of transcription, DNA-templated-ISSProcess
GO:0070888E-box binding-IEAFunction
GO:0071158positive regulation of cell cycle arrest21471221.IMPProcess
GO:0072332intrinsic apoptotic signaling pathway by p53 class mediator21471221.IMPProcess
GO:2000210positive regulation of anoikis23388179.IMPProcess
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