EuRBPDB

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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
26583126High LIN28A Expressing Ovarian Cancer Cells Secrete Exosomes That Induce Invasion and Migration in HEK293 Cells.Biomed Res Int2015Enriquez VAdoi: 10.1155/2015/701390
30256974Long non-coding RNA Linc00662 promotes cell invasion and contributes to cancer stem cell-like phenotypes in lung cancer cells.J Biochem2018 Dec 1Gong Wdoi: 10.1093/jb/mvy078.
22532168Induction of the RNA regulator LIN28A is required for the growth and pathogenesis of RESTless breast tumors.Cancer Res2012 Jul 1Gunsalus KTdoi: 10.1158/0008-5472.CAN-11-1639
22429493LIN28 expression and prognostic value in hepatocellular carcinoma patients who meet the Milan criteria and undergo hepatectomy.Chin J Cancer2012 MayQiu JLdoi: 10.5732/cjc.011.10426
23161096LIN28A immunoreactivity is a potent diagnostic marker of embryonal tumor with multilayered rosettes (ETMR).Acta Neuropathol2012 DecKorshunov Adoi: 10.1007/s00401-012-1068-3
24311633A novel C19MC amplified cell line links Lin28/let-7 to mTOR signaling in embryonal tumor with multilayered rosettes.Neuro Oncol2014 JanSpence Tdoi: 10.1093/neuonc/not162
26687759Lin28A enhances chemosensitivity of colon cancer cells to 5-FU by promoting apoptosis in a let-7 independent manner.Tumour Biol2016 JunWang Tdoi: 10.1007/s13277-015-4559-8
25956904LIN28 cooperates with WNT signaling to drive invasive intestinal and colorectal adenocarcinoma in mice and humans.Genes Dev2015 May 15Tu HCdoi: 10.1101/gad.256693.114
28744687LIN28A, a sensitive immunohistochemical marker for Embryonal Tumor with Multilayered Rosettes (ETMR), is also positive in a subset of Atypical Teratoid/Rhabdoid Tumor (AT/RT).Childs Nerv Syst2017 NovRao Sdoi: 10.1007/s00381-017-3551-6
30531691Role of Lin28A/let-7a/c-Myc Pathway in Growth and Malignant Behavior of Papillary Thyroid Carcinoma.Med Sci Monit2018 Dec 9Huang Jdoi: 10.12659/MSM.908628.
26714839Lin28 induces resistance to anti-androgens via promotion of AR splice variant generation.Prostate2016 AprTummala Rdoi: 10.1002/pros.23134
22433967High expression of Lin28 is associated with tumour aggressiveness and poor prognosis of patients in oesophagus cancer.Br J Cancer2012 Apr 10Hamano Rdoi: 10.1038/bjc.2012.90
30266988The interaction of Lin28A/Rho associated coiled-coil containing protein kinase2 accelerates the malignancy of ovarian cancer.Oncogene2019 FebZhong Ydoi: 10.1038/s41388-018-0512-9
19483683Lin28 promotes transformation and is associated with advanced human malignancies.Nat Genet2009 JulViswanathan SRdoi: 10.1038/ng.392
26898455Let-7a mimic attenuates CCL18 induced breast cancer cell metastasis through Lin 28 pathway.Biomed Pharmacother2016 MarWang Ldoi: 10.1016/j.biopha.2016.01.028
20947512Identification of microRNAs regulating reprogramming factor LIN28 in embryonic stem cells and cancer cells.J Biol Chem2010 Dec 31Zhong Xdoi: 10.1074/jbc.M110.169607
25128063Lin28 promotes Her2 expression and Lin28/Her2 predicts poorer survival in gastric cancer.Tumour Biol2014 NovWang Qdoi: 10.1007/s13277-014-2481-0
19703396TUT4 in concert with Lin28 suppresses microRNA biogenesis through pre-microRNA uridylation.Cell2009 Aug 21Heo Idoi: 10.1016/j.cell.2009.08.002.
26149387LIN28A Modulates Splicing and Gene Expression Programs in Breast Cancer Cells.Mol Cell Biol2015 SepYang Jdoi: 10.1128/MCB.00426-15
24349438Lin28 induces epithelial-to-mesenchymal transition and stemness via downregulation of let-7a in breast cancer cells.PLoS One2013 Dec 11Liu Ydoi: 10.1371/journal.pone.0083083
22808086Lin28 mediates paclitaxel resistance by modulating p21, Rb and Let-7a miRNA in breast cancer cells.PLoS One2012Lv Kdoi: 10.1371/journal.pone.0040008
22467868Lin-28 homologue A (LIN28A) promotes cell cycle progression via regulation of cyclin-dependent kinase 2 (CDK2), cyclin D1 (CCND1), and cell division cycle 25 homolog A (CDC25A) expression in cancer.J Biol Chem2012 May 18Li Ndoi: 10.1074/jbc.M111.321158
23255092Lin28 regulates BMP4 and functions with Oct4 to affect ovarian tumor microenvironment.Cell Cycle2013 Jan 1Ma Wdoi: 10.4161/cc.23028
25515921Overexpression of Lin28 inhibits the proliferation, migration and cell cycle progression and induces apoptosis of BGC-823 gastric cancer cells.Oncol Rep2015 FebSong Hdoi: 10.3892/or.2014.3674
23790802Lin28 promotes growth of prostate cancer cells and activates the androgen receptor.Am J Pathol2013 JulTummala Rdoi: 10.1016/j.ajpath.2013.03.011.
21045151Double-negative feedback loop between reprogramming factor LIN28 and microRNA let-7 regulates aldehyde dehydrogenase 1-positive cancer stem cells.Cancer Res2010 Nov 15Yang Xdoi: 10.1158/0008-5472.CAN-10-2388
21912531Germline genetic variants disturbing the Let-7/LIN28 double-negative feedback loop alter breast cancer susceptibility.PLoS Genet2011 SepChen AXdoi: 10.1371/journal.pgen.1002259
25200669Expression of LIN28 and its regulatory microRNAs in adult adrenocortical cancer.Clin Endocrinol (Oxf)2015 AprFaria AMdoi: 10.1111/cen.12607
23307247A signature for induced pluripotent stem cell-associated genes in colorectal cancer.Med Oncol2013 MarLiu YHdoi: 10.1007/s12032-012-0426-2
23613467The Wnt-β-catenin pathway represses let-7 microRNA expression through transactivation of Lin28 to augment breast cancer stem cell expansion.J Cell Sci2013 Jul 1Cai WYdoi: 10.1242/jcs.123810
23500413Lin28a is a putative factor in regulating cancer stem cell-like properties in side population cells of oral squamous cell carcinoma.Exp Cell Res2013 May 1Hayashi Sdoi: 10.1016/j.yexcr.2013.03.004
23840685Lin28 mediates radiation resistance of breast cancer cells via regulation of caspase, H2A.X and Let-7 signaling.PLoS One2013 Jun 20Wang Ldoi: 10.1371/journal.pone.0067373
26945970RNA-binding protein Lin28 in cancer and immunity.Cancer Lett2016 May 28Jiang Sdoi: 10.1016/j.canlet.2016.02.050
20101213Pluripotency factors Lin28 and Oct4 identify a sub-population of stem cell-like cells in ovarian cancer.Oncogene2010 Apr 8Peng Sdoi: 10.1038/onc.2009.500
22713243Lin28 regulates HER2 and promotes malignancy through multiple mechanisms.Cell Cycle2012 Jul 1Feng Cdoi: 10.4161/cc.20893
27859935Single nucleotide polymorphisms within MicroRNAs, MicroRNA targets, and MicroRNA biogenesis genes and their impact on colorectal cancer survival.Genes Chromosomes Cancer2017 AprMullany LEdoi: 10.1002/gcc.22434
27721018Musashi 2 contributes to the stemness and chemoresistance of liver cancer stem cells via LIN28A activation.Cancer Lett2017 Jan 1Fang Tdoi: 10.1016/j.canlet.2016.10.007
28235063Disturbance of the let-7/LIN28 double-negative feedback loop is associated with radio- and chemo-resistance in non-small cell lung cancer.PLoS One2017 Feb 24Yin Jdoi: 10.1371/journal.pone.0172787
26910839MeCP2 suppresses LIN28A expression via binding to its methylated-CpG islands in pancreatic cancer cells.Oncotarget2016 Mar 22Xu Mdoi: 10.18632/oncotarget.7507.
27494865Lin28A activates androgen receptor via regulation of c-myc and promotes malignancy of ER-/Her2+ breast cancer.Oncotarget2016 Sep 13Shen Hdoi: 10.18632/oncotarget.11004.
27793004Comparison of the expression and function of Lin28A and Lin28B in colon cancer.Oncotarget2016 Nov 29Wang Tdoi: 10.18632/oncotarget.12869.
28846452Concise Review: LIN28/let-7 Signaling, a Critical Double-Negative Feedback Loop During Pluripotency, Reprogramming, and Tumorigenicity.Cell Reprogram2017 OctFarzaneh Mdoi: 10.1089/cell.2017.0015
29749495LIN28A inhibits lysosomeassociated membrane glycoprotein 1 protein expression in embryonic stem and bladder cancer cells.Mol Med Rep2018 JulPan Pdoi: 10.3892/mmr.2018.8965
30833806Lethal-7-related polymorphisms are associated with susceptibility to and prognosis of gastric cancer.World J Gastroenterol2019 Feb 28Jia ZFdoi: 10.3748/wjg.v25.i8.1012.

Differential Expression

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
BLCAchr126426395SilentNAT189T0.23
BLCAchr126411483SilentnovelI43I0.37
BLCAchr126426311Missense_MutationnovelC161W0.1
BLCAchr126426270Missense_MutationNAH148Y0.26CSD
BRCAchr1264108465'UTRnovel0.14
BRCAchr1264293963'UTRnovel0.1
BRCAchr126426301Missense_MutationnovelP158L0.13
BRCAchr1264107995'Flanknovel0.18
CESCchr126426346Nonsense_MutationNAS173*0.16
CESCchr1264273873'UTRnovel0.18
CESCchr1264274803'UTRnovel0.18
CESCchr126426403Missense_Mutationrs748187241R192Q0.17
COADchr126425371Missense_MutationNAK99N0.28
COADchr126411502Missense_MutationNAR50C0.21
COADchr1264107825'Flanknovel0.26
COADchr126411513Silentrs760812729F53F0.5
COADchr126411540SilentnovelA62A0.35
COADchr1264265263'UTRnovel0.36
COADchr126426397Nonsense_MutationnovelY190*0.05
ESCAchr1264268993'UTRnovel0.5
GBMchr126426402Nonsense_MutationNAR192*0.48
HNSCchr126426337Missense_MutationnovelM170T0.09
HNSCchr126425441Missense_Mutationrs761336362R123W0.08
HNSCchr126426323Missense_MutationnovelQ165H0.12
HNSCchr126426307Missense_MutationnovelK160T0.28
KIRPchr1264266563'UTRnovel0.55
LGGchr126425380Missense_MutationnovelK102N0.08
LUADchr126425409Missense_MutationNAP112L0.07
LUADchr126411548Missense_Mutationrs759205887A65V0.3
LUADchr126425339Missense_MutationnovelE89K0.19
LUADchr126425315Missense_MutationnovelM81V0.19
LUSCchr126425437SilentnovelE121E0.4
LUSCchr126426391Missense_Mutationrs748777822P188Q0.08
LUSCchr126425405Missense_Mutationrs768587147G111R0.65
LUSCchr126426385Missense_MutationNAG186E0.17
READchr1264264813'UTRnovel0.51
READchr1264108095'Flanknovel0.52
SARCchr1264279353'UTRnovel0.38
SARCchr1264295373'UTRnovel0.53
SKCMchr1264108295'UTRnovel0.3
SKCMchr126411385Splice_SitenovelX11_splice0.4
SKCMchr126425451Missense_Mutationrs141345172G126E0.32
SKCMchr126426398SilentNAY190Y0.4
SKCMchr126425451Missense_Mutationrs141345172G126E0.33
SKCMchr1264108245'UTRnovel0.21
SKCMchr126426457SilentNA*210*0.17
SKCMchr126425451Missense_Mutationrs141345172G126E0.19
SKCMchr126425429Missense_MutationNAG119R0.32
SKCMchr1264264723'UTRnovel0.19
SKCMchr126425386SilentNAL104L0.21
STADchr126426332SilentNAS168S0.24
STADchr126411536Missense_MutationnovelR61H0.26
STADchr126425404Silentrs372279965T110T0.2
STADchr126411503Missense_MutationnovelR50H0.26
UCECchr1264294383'UTRnovel0.44
UCECchr126411463SilentnovelL37L0.46
UCECchr126426402Nonsense_MutationNAR192*0.46
UCECchr126411393SilentnovelC13C0.5
UCECchr1264270343'UTRnovel0.32
UCECchr1264274383'UTRnovel0.41
UCECchr1264278173'UTRnovel0.39
UCECchr126411511Missense_MutationnovelF53L0.19
UCECchr1264268993'UTRnovel0.55
UCECchr1264282553'UTRnovel0.26
UCECchr1264271683'UTRnovel0.45
UCECchr1264282833'UTRnovel0.48
UCECchr1264294403'UTRnovel0.46
UCECchr1264272133'UTRnovel0.3
UCECchr1264293673'UTRnovel0.38
UCECchr1264273683'UTRnovel0.35
UCECchr1264271153'UTRnovel0.35
UCECchr126425461Missense_MutationNAM129I0.41
UCECchr126411502Missense_MutationNAR50C0.47
UCECchr126425461Missense_MutationNAM129I0.55
UCECchr126426250Missense_MutationnovelN141S0.38CSD
UCECchr1264268993'UTRnovel0.31
UCECchr1264271153'UTRnovel0.25
UCECchr1264268993'UTRnovel0.53
UCECchr1264282573'UTRnovel0.29
UCECchr1264281443'UTRnovel0.16
UCECchr1264280303'UTRnovel0.32
UCECchr1264264813'UTRnovel0.3
UCECchr1264269213'UTRnovel0.33
UCECchr1264273183'UTRnovel0.07
UCECchr1264293833'UTRnovel0.21
UCECchr126410902Missense_MutationNAV4A0.27
UCECchr1264270953'UTRnovel0.37

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
CESCDEL0.09490.00029523
CHOLDEL0.77783.3987e-23
COADDEL0.32594.7302e-24
DLBCDEL0.10420.011841
ESCADEL0.29350.0012162
HNSCDEL0.1367.0766e-07
KIRCDEL0.15152.3538e-09
KIRPDEL0.17361.462e-09
LIHCDEL0.34861.6679e-20
LUADDEL0.17250.0024765
LUSCDEL0.37722.5882e-07
MESODEL0.26442.434e-07
READDEL0.42.1758e-10
TGCTDEL0.160.00046313

Survival Analysis
CancerP-value Q-value
KIRC0.014

Kaplan-Meier Survival Analysis

LUSC0.049

Kaplan-Meier Survival Analysis

BRCA0.0058

Kaplan-Meier Survival Analysis

LAML0.037

Kaplan-Meier Survival Analysis

Drugs

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Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBDs
  • Literatures
  • Expression
  • Transcripts
  • Gene Model
  • Phenotypes
  • GWAS
  • PPI
  • Paralogs
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000131914 (Gene tree)
Gene ID
79727
Gene Symbol
LIN28A
Alias
LIN-28|FLJ12457|ZCCHC1|CSDD1|LIN28
Full Name
lin-28 homolog A
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Plus strand
Length
18,951 bases
Position
chr1:26,410,778-26,429,728
Accession
15986
RBP type
canonical RBP
Summary
This gene encodes a LIN-28 family RNA-binding protein that acts as a posttranscriptional regulator of genes involved in developmental timing and self-renewal in embryonic stem cells. The encoded protein functions through direct interaction with target mRNAs and by disrupting the maturation of certain miRNAs involved in embryonic development. This protein prevents the terminal processing of the LET7 family of microRNAs which are major regulators of cellular growth and differentiation. Aberrant expression of this gene is associated with cancer progression in multiple tissues. [provided by RefSeq, Sep 2015]
RNA binding domains(RBDs)
Protein IDDomain Pfam IDE-value Domain number Total number
ENSP00000254231CSDPF00313.225.8e-1611
ENSP00000363314CSDPF00313.225.8e-1611
ENSP00000254231zf-CCHCPF00098.234.4e-0611
ENSP00000363314zf-CCHCPF00098.234.4e-0611

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
12871707The time of appearance of the C. elegans let-7 microRNA is transcriptionally controlled utilizing a temporal regulatory element in its promoter.Dev Biol2003 Jul 15Johnson SM-
21553022Lin-28 reactivation is required for let-7 repression and proliferation in human small cell lung cancer cells.Mol Cell Biochem2011 SepPan Ldoi: 10.1007/s11010-011-0862-x
25544363Regulatory networks between neurotrophins and miRNAs in brain diseases and cancers.Acta Pharmacol Sin2015 FebShi Jdoi: 10.1038/aps.2014.135
28132840A Rapid Induction Mechanism for Lin28a in Trophic Responses.Mol Cell2017 Feb 2Amen AMdoi: 10.1016/j.molcel.2016.12.025
30770392Trans-splicing of the C. elegans let-7 primary transcript developmentally regulates let-7 microRNA biogenesis and let-7 family microRNA activity.Development2019 Mar 4Nelson Cdoi: 10.1242/dev.172031.
17617744Localization of the developmental timing regulator Lin28 to mRNP complexes, P-bodies and stress granules.RNA Biol2007 Jan-MarBalzer E-
23335963Differential processing of let-7a precursors influences RRM2 expression and chemosensitivity in pancreatic cancer: role of LIN-28 and SET oncoprotein.PLoS One2013Bhutia YDdoi: 10.1371/journal.pone.0053436
22162396RNA-binding protein L1TD1 interacts with LIN28 via RNA and is required for human embryonic stem cell self-renewal and cancer cell proliferation.Stem Cells2012 MarNarva Edoi: 10.1002/stem.1013.
27881476Lin28a uses distinct mechanisms of binding to RNA and affects miRNA levels positively and negatively.RNA2017 MarNowak JSdoi: 10.1261/rna.059196.116
23482325Lin28b promotes head and neck cancer progression via modulation of the insulin-like growth factor survival pathway.Oncotarget2012 DecAlajez NM-
29204769RNA binding protein Lin28A promotes osteocarcinoma cells progression by associating with the long noncoding RNA MALAT1.Biotechnol Lett2018 MarWang Zdoi: 10.1007/s10529-017-2489-9
29540527A biosensor for MAPK-dependent Lin28 signaling.Mol Biol Cell2018 May 15Oldach LMdoi: 10.1091/mbc.E17-08-0500
30076414Long noncoding RNA PVT1-214 promotes proliferation and invasion of colorectal cancer by stabilizing Lin28 and interacting with miR-128.Oncogene2019 JanHe Fdoi: 10.1038/s41388-018-0432-8
22013165Importance of the NCp7-like domain in the recognition of pre-let-7g by the pluripotency factor Lin28.Nucleic Acids Res2012 FebDesjardins Adoi: 10.1093/nar/gkr808
23728999Perturbation of MicroRNA-370/Lin-28 homolog A/nuclear factor kappa B regulatory circuit contributes to the development of hepatocellular carcinoma.Hepatology2013 DecXu WPdoi: 10.1002/hep.26541
25794352RELB Alters Proliferation of Human Pluripotent Stem Cells via IMP3- and LIN28-Mediated Modulation of the Expression of IGF2 and Other Cell-Cycle Regulators.Stem Cells Dev2015 Aug 15Thakar NYdoi: 10.1089/scd.2014.0587
30734494Critical role of Lin28-TNFR2 signalling in cardiac stem cell activation and differentiation.J Cell Mol Med2019 AprXiang Qdoi: 10.1111/jcmm.14202
12798299Conservation of the heterochronic regulator Lin-28, its developmental expression and microRNA complementary sites.Dev Biol2003 Jun 15Moss EG-
14643679Temporally regulated expression of Lin-28 in diverse tissues of the developing mouse.Gene Expr Patterns2003 DecYang DH-
23420006LIN28/LIN28B: an emerging oncogenic driver in cancer stem cells.Int J Biochem Cell Biol2013 MayZhou Jdoi: 10.1016/j.biocel.2013.02.006
20178735Lin28: A microRNA regulator with a macro role.Cell2010 Feb 19Viswanathan SRdoi: 10.1016/j.cell.2010.02.007.
20179095LIN28 alters cell fate succession and acts independently of the let-7 microRNA during neurogliogenesis in vitro.Development2010 MarBalzer Edoi: 10.1242/dev.042895.
20101213Pluripotency factors Lin28 and Oct4 identify a sub-population of stem cell-like cells in ovarian cancer.Oncogene2010 Apr 8Peng Sdoi: 10.1038/onc.2009.500
19713958Lin28 recruits the TUTase Zcchc11 to inhibit let-7 maturation in mouse embryonic stem cells.Nat Struct Mol Biol2009 OctHagan JPdoi: 10.1038/nsmb.1676
19557079Tumors line up for a letdown.Nat Genet2009 JulMendell JTdoi: 10.1038/ng0709-768.
19477633Pluripotent factor lin-28 and its homologue lin-28b in epithelial ovarian cancer and their associations with disease outcomes and expression of let-7a and IGF-II.Eur J Cancer2009 AugLu Ldoi: 10.1016/j.ejca.2009.05.003
19483683Lin28 promotes transformation and is associated with advanced human malignancies.Nat Genet2009 JulViswanathan SRdoi: 10.1038/ng.392
19211792Lin-28B transactivation is necessary for Myc-mediated let-7 repression and proliferation.Proc Natl Acad Sci U S A2009 Mar 3Chang TCdoi: 10.1073/pnas.0808300106
18951094Lin28 mediates the terminal uridylation of let-7 precursor MicroRNA.Mol Cell2008 Oct 24Heo Idoi: 10.1016/j.molcel.2008.09.014.
22959275LIN28 binds messenger RNAs at GGAGA motifs and regulates splicing factor abundance.Mol Cell2012 Oct 26Wilbert MLdoi: 10.1016/j.molcel.2012.08.004
18550544Determinants of microRNA processing inhibition by the developmentally regulated RNA-binding protein Lin28.J Biol Chem2008 Aug 1Piskounova Edoi: 10.1074/jbc.C800108200
18292307Selective blockade of microRNA processing by Lin28.Science2008 Apr 4Viswanathan SRdoi: 10.1126/science.1154040
17473174Lin-28 binds IGF-2 mRNA and participates in skeletal myogenesis by increasing translation efficiency.Genes Dev2007 May 1Polesskaya A-
22784697How does Lin28 let-7 control development and disease?Trends Cell Biol2012 SepThornton JEdoi: 10.1016/j.tcb.2012.06.001
22713243Lin28 regulates HER2 and promotes malignancy through multiple mechanisms.Cell Cycle2012 Jul 1Feng Cdoi: 10.4161/cc.20893
22689537The pluripotency factor LIN28 in monkey and human testes: a marker for spermatogonial stem cells?Mol Hum Reprod2012 OctAeckerle N-
22570413The Lin28 cold-shock domain remodels pre-let-7 microRNA.Nucleic Acids Res2012 AugMayr Fdoi: 10.1093/nar/gks355
22457637lin-28 controls the succession of cell fate choices via two distinct activities.PLoS Genet2012Vadla Bdoi: 10.1371/journal.pgen.1002588
22467269A mirror of two faces: Lin28 as a master regulator of both miRNA and mRNA.Wiley Interdiscip Rev RNA2012 Jul-AugHuang Ydoi: 10.1002/wrna.1112
22467868Lin-28 homologue A (LIN28A) promotes cell cycle progression via regulation of cyclin-dependent kinase 2 (CDK2), cyclin D1 (CCND1), and cell division cycle 25 homolog A (CDC25A) expression in cancer.J Biol Chem2012 May 18Li Ndoi: 10.1074/jbc.M111.321158
23337528Distinct expression patterns predict differential roles of the miRNA-binding proteins, Lin28 and Lin28b, in the mouse testis: studies during postnatal development and in a model of hypogonadotropic hypogonadism.Endocrinology2013 MarGaytan Fdoi: 10.1210/en.2012-1745
23344711Lin28 proteins are required for germ layer specification in Xenopus.Development2013 MarFaas Ldoi: 10.1242/dev.089797
22296229LIN28 is selectively expressed by primordial and pre-meiotic germ cells in the human fetal ovary.Stem Cells Dev2012 Sep 1Childs AJdoi: 10.1089/scd.2011.0730
22081076LIN28: a regulator of tumor-suppressing activity of let-7 microRNA in human breast cancer.J Steroid Biochem Mol Biol2012 SepSakurai Mdoi: 10.1016/j.jsbmb.2011.10.007
22034885RNA-binding protein LIN28 is a sensitive marker of ovarian primitive germ cell tumours.Histopathology2011 SepXue Ddoi: 10.1111/j.1365-2559.2011.03949.x.
21979467MiR-181 mediates cell differentiation by interrupting the Lin28 and let-7 feedback circuit.Cell Death Differ2012 MarLi Xdoi: 10.1038/cdd.2011.127
21982546RNA-binding proteins and gene regulation in myogenesis.Trends Pharmacol Sci2011 NovApponi LHdoi: 10.1016/j.tips.2011.06.004
21962509The Lin28/let-7 axis regulates glucose metabolism.Cell2011 Sep 30Zhu Hdoi: 10.1016/j.cell.2011.08.033.
21815640A LIN28-dependent structural change in pre-let-7g directly inhibits dicer processing.Biochemistry2011 Sep 6Lightfoot HLdoi: 10.1021/bi200851d
23291449Changes in hypothalamic expression of the Lin28/let-7 system and related microRNAs during postnatal maturation and after experimental manipulations of puberty.Endocrinology2013 FebSangiao-Alvarellos Sdoi: 10.1210/en.2012-2006
21755474Regulation of pre-miRNA Processing.Adv Exp Med Biol2011Lehrbach NJ-
21627031Regulation of pre-miRNA processing.Adv Exp Med Biol2010Lehrbach NJ-
21288558RNA-binding protein LIN28 is a marker for testicular germ cell tumors.Hum Pathol2011 MayCao Ddoi: 10.1016/j.humpath.2010.09.007
21247876Evidence that Lin28 stimulates translation by recruiting RNA helicase A to polysomes.Nucleic Acids Res2011 MayJin Jdoi: 10.1093/nar/gkq1350
21057460RNA-binding protein LIN28 is a marker for primary extragonadal germ cell tumors: an immunohistochemical study of 131 cases.Mod Pathol2011 FebCao Ddoi: 10.1038/modpathol.2010.195
20947512Identification of microRNAs regulating reprogramming factor LIN28 in embryonic stem cells and cancer cells.J Biol Chem2010 Dec 31Zhong Xdoi: 10.1074/jbc.M110.169607
20512147Lin28a transgenic mice manifest size and puberty phenotypes identified in human genetic association studies.Nat Genet2010 JulZhu Hdoi: 10.1038/ng.593
20525879Lin-28B expression promotes transformation and invasion in human hepatocellular carcinoma.Carcinogenesis2010 SepWang YCdoi: 10.1093/carcin/bgq107
23162570Does Lin28 Antagonize miRNA-Mediated Repression by Displacing miRISC from Target mRNAs?Front Genet2012 Nov 16Kallen ANdoi: 10.3389/fgene.2012.00240
25457611Trim25 Is an RNA-Specific Activator of Lin28a/TuT4-Mediated Uridylation.Cell Rep2014 Nov 20Choudhury NR-
25378324Short loop-targeting oligoribonucleotides antagonize Lin28 and enable pre-let-7 processing and suppression of cell growth in let-7-deficient cancer cells.Nucleic Acids Res2015 JanRoos Mdoi: 10.1093/nar/gku1090
25269502[Research progress of Lin28 function].Zhong Nan Da Xue Xue Bao Yi Xue Ban2014 SepShen Hdoi: 10.11817/j.issn.1672-7347.2014.09.017.
25201220A potential regulatory loop between Lin28B:miR212 in androgen-independent prostate cancer.Int J Oncol2014 DecBorrego-Diaz Edoi: 10.3892/ijo.2014.2647
25117712Lin28b is sufficient to drive liver cancer and necessary for its maintenance in murine models.Cancer Cell2014 Aug 11Nguyen LHdoi: 10.1016/j.ccr.2014.06.018.
27920151Lin28 is induced in primed embryonic stem cells and regulates let-7-independent events.FASEB J2017 MarParisi Sdoi: 10.1096/fj.201600848R
24825413Lin28 and let-7: ancient milestones on the road from pluripotency to neurogenesis.Cell Tissue Res2015 JanRehfeld Fdoi: 10.1007/s00441-014-1872-2
24829024Lin28a is dormant, functional, and dispensable during mouse oocyte-to-embryo transition.Biol Reprod2014 JunFlemr Mdoi: 10.1095/biolreprod.114.118703
24780874Genetic variants of the LIN28B gene predict severe radiation pneumonitis in patients with non-small cell lung cancer treated with definitive radiation therapy.Eur J Cancer2014 JulWen Jdoi: 10.1016/j.ejca.2014.03.008
24700281LIN28 expression in rat spinal cord after injury.Neurochem Res2014 MayYue Ydoi: 10.1007/s11064-014-1278-2
24631505Reversible acetylation of Lin28 mediated by PCAF and SIRT1.Biochim Biophys Acta2014 JunWang LXdoi: 10.1016/j.bbamcr.2014.03.001
24475120LIN28 is involved in glioma carcinogenesis and predicts outcomes of glioblastoma multiforme patients.PLoS One2014 Jan 24Qin Rdoi: 10.1371/journal.pone.0086446
24349438Lin28 induces epithelial-to-mesenchymal transition and stemness via downregulation of let-7a in breast cancer cells.PLoS One2013 Dec 11Liu Ydoi: 10.1371/journal.pone.0083083
24209617Lin28 enhances tissue repair by reprogramming cellular metabolism.Cell2013 Nov 7Shyh-Chang Ndoi: 10.1016/j.cell.2013.09.059.
24142874LIN28B promotes growth and tumorigenesis of the intestinal epithelium via Let-7.Genes Dev2013 Oct 15Madison BBdoi: 10.1101/gad.224659.113.
27798668The Lin28 Expression in Stallion Testes.PLoS One2016 Oct 31Lee Gdoi: 10.1371/journal.pone.0165011
24006280Role of LIN28A in mouse and human trophoblast cell differentiation.Biol Reprod2013 Oct 24Seabrook JLdoi: 10.1095/biolreprod.113.109868
23939427Mechanisms of Lin28-mediated miRNA and mRNA regulation--a structural and functional perspective.Int J Mol Sci2013 Aug 9Mayr Fdoi: 10.3390/ijms140816532.
23806711Expression of exogenous LIN28 contributes to proliferation and survival of mouse primary cortical neurons in vitro.Neuroscience2013 Sep 17Bhuiyan MIdoi: 10.1016/j.neuroscience.2013.06.023
23770886Identification of LIN28B-bound mRNAs reveals features of target recognition and regulation.RNA Biol2013 JulGraf Rdoi: 10.4161/rna.25194
23666760Fetal deficiency of lin28 programs life-long aberrations in growth and glucose metabolism.Stem Cells2013 AugShinoda Gdoi: 10.1002/stem.1423.
23561442Lin28: primal regulator of growth and metabolism in stem cells.Cell Stem Cell2013 Apr 4Shyh-Chang Ndoi: 10.1016/j.stem.2013.03.005.
23545322The expression of the let-7 miRNAs and Lin28 signalling pathway in human term gestational tissues.Placenta2013 MayChan HWdoi: 10.1016/j.placenta.2013.02.008
23481595Identification of mRNAs bound and regulated by human LIN28 proteins and molecular requirements for RNA recognition.RNA2013 MayHafner Mdoi: 10.1261/rna.036491.112
26762415Lin28: an emerging important oncogene connecting several aspects of cancer.Tumour Biol2016 MarWang Hdoi: 10.1007/s13277-015-4759-2
26687759Lin28A enhances chemosensitivity of colon cancer cells to 5-FU by promoting apoptosis in a let-7 independent manner.Tumour Biol2016 JunWang Tdoi: 10.1007/s13277-015-4559-8
26655604A cardiac myocyte-restricted Lin28/let-7 regulatory axis promotes hypoxia-mediated apoptosis by inducing the AKT signaling suppressor PIK3IP1.Biochim Biophys Acta2016 FebJoshi Sdoi: 10.1016/j.bbadis.2015.12.004
27320042LIN28 Regulates Stem Cell Metabolism and Conversion to Primed Pluripotency.Cell Stem Cell2016 Jul 7Zhang Jdoi: 10.1016/j.stem.2016.05.009
26711009Lin28A Binds Active Promoters and Recruits Tet1 to Regulate Gene Expression.Mol Cell2016 Jan 7Zeng Ydoi: 10.1016/j.molcel.2015.11.020
26399619Biogenesis and regulation of the let-7 miRNAs and their functional implications.Protein Cell2016 FebLee Hdoi: 10.1007/s13238-015-0212-y
25922525Lin28 promotes the proliferative capacity of neural progenitor cells in brain development.Development2015 May 1Yang Mdoi: 10.1242/dev.120543.
24311633A novel C19MC amplified cell line links Lin28/let-7 to mTOR signaling in embryonal tumor with multilayered rosettes.Neuro Oncol2014 JanSpence Tdoi: 10.1093/neuonc/not162
27357399RNA-binding protein LIN28 is a sensitive marker of pediatric yolk sac tumors.Pediatr Surg Int2016 AugFeng Sdoi: 10.1007/s00383-016-3922-1
28297670LIN28 Zinc Knuckle Domain Is Required and Sufficient to Induce let-7 Oligouridylation.Cell Rep2017 Mar 14Wang Ldoi: 10.1016/j.celrep.2017.02.044.
26945970RNA-binding protein Lin28 in cancer and immunity.Cancer Lett2016 May 28Jiang Sdoi: 10.1016/j.canlet.2016.02.050
26835354Lin28 and let-7 in cell metabolism and cancer.Transl Pediatr2015 JanNguyen LHdoi: 10.3978/j.issn.2224-4336.2015.01.05.
26748607Blurred Boundaries: The RNA Binding Protein Lin28A Is Also an Epigenetic Regulator.Mol Cell2016 Jan 7Tan FEdoi: 10.1016/j.molcel.2015.12.018.
26583126High LIN28A Expressing Ovarian Cancer Cells Secrete Exosomes That Induce Invasion and Migration in HEK293 Cells.Biomed Res Int2015Enriquez VAdoi: 10.1155/2015/701390
26494358Testicular expression of the Lin28/let-7 system: Hormonal regulation and changes during postnatal maturation and after manipulations of puberty.Sci Rep2015 Oct 23Sangiao-Alvarellos Sdoi: 10.1038/srep15683.
26487778Lin-28 promotes symmetric stem cell division and drives adaptive growth in the adult Drosophila intestine.Development2015 Oct 15Chen CHdoi: 10.1242/dev.127951.
26199409LIN28: roles and regulation in development and beyond.Development2015 Jul 15Tsialikas Jdoi: 10.1242/dev.117580.
26158177Lin28 Mediates Cancer Chemotherapy Resistance via Regulation of miRNA Signaling.Hepatogastroenterology2014 JunXu C-
26149387LIN28A Modulates Splicing and Gene Expression Programs in Breast Cancer Cells.Mol Cell Biol2015 SepYang Jdoi: 10.1128/MCB.00426-15
26114892Identification of small molecule inhibitors of Zcchc11 TUTase activity.RNA Biol2015Lin Sdoi: 10.1080/15476286.2015.1058478.
26045559An RNA-binding Protein, Lin28, Recognizes and Remodels G-quartets in the MicroRNAs (miRNAs) and mRNAs It Regulates.J Biol Chem2015 Jul 17O'Day Edoi: 10.1074/jbc.M115.665521
25956904LIN28 cooperates with WNT signaling to drive invasive intestinal and colorectal adenocarcinoma in mice and humans.Genes Dev2015 May 15Tu HCdoi: 10.1101/gad.256693.114
25805859A novel mechanism of LIN-28 regulation of let-7 microRNA expression revealed by in vivo HITS-CLIP in C. elegans.RNA2015 MayStefani Gdoi: 10.1261/rna.045542.114
25823513Role of MicroRNA Let-7 in Modulating Multifactorial Aspect of Neurodegenerative Diseases: an Overview.Mol Neurobiol2016 JulShamsuzzamadoi: 10.1007/s12035-015-9145-y
28400788The LIN28/let-7 Pathway in Cancer.Front Genet2017 Mar 28Balzeau Jdoi: 10.3389/fgene.2017.00031
28569789Knockdown of miR-128a induces Lin28a expression and reverts myeloid differentiation blockage in acute myeloid leukemia.Cell Death Dis2017 Jun 1De Luca Ldoi: 10.1038/cddis.2017.253.
28683410Different expression patterns of Lin28 and Lin28b in mouse molar development.Arch Oral Biol2017 OctDong Ndoi: 10.1016/j.archoralbio.2017.06.023
28745393Beyond an oncogene, Lin28 is a master regulator of cancer progression.Histol Histopathol2018 AprWang Xdoi: 10.14670/HH-11-922
28768505Tough decoy targeting of predominant let-7 miRNA species in adult human hematopoietic cells.J Transl Med2017 Aug 2de Vasconcellos JFdoi: 10.1186/s12967-017-1273-x.
28771809Role of XIST/miR-29a/LIN28A pathway in denatured dermis and human skin fibroblasts (HSFs) after thermal injury.J Cell Biochem2018 FebGuo Ldoi: 10.1002/jcb.26307
29143345Lin28a enhances in vitro osteoblastic differentiation of human periosteum-derived cells.Cell Biochem Funct2017 DecPark JHdoi: 10.1002/cbf.3305
29212015Opposing Post-transcriptional Control of InR by FMRP and LIN-28 Adjusts Stem Cell-Based Tissue Growth.Cell Rep2017 Dec 5Luhur Adoi: 10.1016/j.celrep.2017.11.039.
29218439Characterization and expression of lin-28a involved in lin28/let-7signal pathway during early development of P. olivaceus.Fish Physiol Biochem2018 AprFu Ydoi: 10.1007/s10695-017-0445-1
29226952Differential expression of microRNAs let-7a, miR-125b, miR-100, and miR-21 and interaction with NF-kB pathway genes in periodontitis pathogenesis.J Cell Physiol2018 AugVenugopal Pdoi: 10.1002/jcp.26391
29301498PCAF-mediated acetylation of Lin28B increases let-7 biogenesis in lung adenocarcinoma H1299 cells.BMC Cancer2018 Jan 4Qu TTdoi: 10.1186/s12885-017-3959-0.
29393461Lin28/microRNA-let-7a promotes metastasis under circumstances of hyperactive Wnt signaling in esophageal squamous cell carcinoma.Mol Med Rep2018 AprLing Rdoi: 10.3892/mmr.2018.8548
29874593Small-Molecule Inhibitors Disrupt let-7 Oligouridylation and Release the Selective Blockade of let-7 Processing by LIN28.Cell Rep2018 Jun 5Wang Ldoi: 10.1016/j.celrep.2018.04.116.
30029005LIN28 Selectively Modulates a Subclass of Let-7 MicroRNAs.Mol Cell2018 Jul 19Ustianenko Ddoi: 10.1016/j.molcel.2018.06.029.
300579013' RNA Uridylation in Epitranscriptomics, Gene Regulation, and Disease.Front Mol Biosci2018 Jul 13Menezes MRdoi: 10.3389/fmolb.2018.00061
30137214HMGA2 is regulated by LIN28 and BRCA1 in human placental cells.Biol Reprod2019 Jan 1West RCdoi: 10.1093/biolre/ioy183.
30184489Lin28 Signaling Supports Mammalian PNS and CNS Axon Regeneration.Cell Rep2018 Sep 4Wang XWdoi: 10.1016/j.celrep.2018.07.105.
30196987Expression of RNA-binding protein LIN28 in classic gastric hepatoid carcinomas, gastric fetal type gastrointestinal adenocarcinomas, and hepatocellular carcinomas: An immunohistochemical study with comparison to SALL4, alpha-fetoprotein, glypican-3, and Hep Par1.Pathol Res Pract2018 OctZhao Mdoi: 10.1016/j.prp.2018.07.037
30203263Persistent Lin28 Expression Impairs Neurite Outgrowth and Cognitive Function in the Developing Mouse Neocortex.Mol Neurobiol2019 MayJang HJdoi: 10.1007/s12035-018-1297-0
30266988The interaction of Lin28A/Rho associated coiled-coil containing protein kinase2 accelerates the malignancy of ovarian cancer.Oncogene2019 FebZhong Ydoi: 10.1038/s41388-018-0512-9
30365085High LIN28A and PLK4 coexpression is associated with poor prognosis in epithelial ovarian cancer.Mol Med Rep2018 DecHe Ydoi: 10.3892/mmr.2018.9562
30415010In-depth study of lin-28 suggests selectively conserved let-7 independent mechanism in Drosophila.Gene2019 Mar 1Lee Mdoi: 10.1016/j.gene.2018.11.017
30423261The RNA-binding protein LIN28 controls progenitor and neuronal cell fate during postnatal neurogenesis.FASEB J2019 MarRomer-Seibert JSdoi: 10.1096/fj.201801118R
30483311Function and Regulation of Human Terminal Uridylyltransferases.Front Genet2018 Nov 12Yashiro Ydoi: 10.3389/fgene.2018.00538
30527666A Transcriptome-wide Translational Program Defined by LIN28B Expression Level.Mol Cell2019 Jan 17Tan FEdoi: 10.1016/j.molcel.2018.10.041
30543854The stability and oncogenic function of LIN28A are regulated by USP28.Biochim Biophys Acta Mol Basis Dis2019 Mar 1Haq Sdoi: 10.1016/j.bbadis.2018.12.006
30578789Transdifferentiation effects and related mechanisms of nerve growth factor and internal limiting membrane on Muller cells.Exp Eye Res2019 MarZhang Ldoi: 10.1016/j.exer.2018.12.005
30626732The microRNAs let-7 and miR-9 down-regulate the axon-guidance genes Ntn1 and Dcc during peripheral nerve regeneration.J Biol Chem2019 Mar 8Wang Xdoi: 10.1074/jbc.RA119.007389
30651289LIN28/let-7/PD-L1 Pathway as a Target for Cancer Immunotherapy.Cancer Immunol Res2019 MarChen Ydoi: 10.1158/2326-6066.CIR-18-0331
30713156Lin28 is a critical factor in the function and aging of Drosophila testis stem cell niche.Aging (Albany NY)2019 Feb 4Sreejith Pdoi: 10.18632/aging.101765.
30851545Lin28 promotes dental pulp cell proliferation via upregulation of cyclin-dependent proteins and interaction with let-7a/IGF2BP2 pathways.Biomed Pharmacother2019 MayLiu Ydoi: 10.1016/j.biopha.2019.108742
30886404RNA structure maps across mammalian cellular compartments.Nat Struct Mol Biol2019 AprSun Ldoi: 10.1038/s41594-019-0200-7
31064784Lin28-mediated temporal promotion of protein synthesis is crucial for neural progenitor cell maintenance and brain development in mice.Development2019 May 28Herrlinger Sdoi: 10.1242/dev.173765.
31075852Molecular Characterization, Bioinformatic Analysis, and Expression Profile of Lin-28 Gene and Its Protein from Arabian Camel (Camelus dromedarius).Int J Mol Sci2019 May 9Alharbi SNdoi: 10.3390/ijms20092291.
31140103LIN28A-stabilized FBXL19-AS1 promotes breast cancer migration, invasion and EMT by regulating WDR66.In Vitro Cell Dev Biol Anim2019 JunZhang Ydoi: 10.1007/s11626-019-00361-4
31301196Temporal regulation of Lin28a during mammalian neurulation contributes to neonatal body size control.Dev Dyn2019 Jul 13Miyazawa Hdoi: 10.1002/dvdy.87
24452802Stepwise assembly of multiple Lin28 proteins on the terminal loop of let-7 miRNA precursors.Nucleic Acids Res2014 AprDesjardins Adoi: 10.1093/nar/gkt1391
22210884Determinants of mRNA recognition and translation regulation by Lin28.Nucleic Acids Res2012 AprLei XXdoi: 10.1093/nar/gkr1279
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30828587Induction of Expandable Tissue-Specific Progenitor Cells from Human Pancreatic Tissue through Transient Expression of Defined Factors.Mol Ther Methods Clin Dev2019 Jan 29Noguchi Hdoi: 10.1016/j.omtm.2019.01.011
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000326279LIN28A-2024008XM_011542148ENSP00000363314209 (aa)XP_011540450Q9H9Z2
ENST00000254231LIN28A-2013458-ENSP00000254231209 (aa)-Q9H9Z2
Gene Model
Click here to download ENSG00000131914's gene model file
Phenotypes
ensgIDTraitpValuePubmed ID
ENSG00000131914Child Development Disorders, Pervasive2.1091700E-005-
ENSG00000131914Body Height3E-820881960
GWAS
ensgIDSNPChromosomePositionSNP-risk TraitPubmedID95% CIOr or BEAT EFO ID
ENSG00000131914rs7532866126415053AHeight20881960[NR] unit increase0.021EFO_0004339
ENSG00000131914rs6694351126424492?Lung function (FVC)30595370EFO_0004312
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000131914's network

* RBP PPI network refers to all genes directly bind to RBP
Paralogs
Ensembl IDGene SymbolCoverageIdentiy ParalogGene SymbolCoverageIdentiy
ENSG00000131914LIN28A8572.626ENSG00000187772LIN28B7677.358
Orthologs
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000131914LIN28A8171.598ENSAPOG00000014331lin28a7677.397Acanthochromis_polyacanthus
ENSG00000131914LIN28A9872.330ENSAPOG00000024256si:ch1073-284b18.28978.736Acanthochromis_polyacanthus
ENSG00000131914LIN28A7373.750ENSAPOG00000014016lin28b5979.310Acanthochromis_polyacanthus
ENSG00000131914LIN28A10079.426ENSAMEG00000019027-10077.990Ailuropoda_melanoleuca
ENSG00000131914LIN28A10094.286ENSAMEG00000010582-10092.857Ailuropoda_melanoleuca
ENSG00000131914LIN28A8672.376ENSAMEG00000011453LIN28B6477.500Ailuropoda_melanoleuca
ENSG00000131914LIN28A9672.277ENSACIG00000017279si:ch1073-284b18.28779.882Amphilophus_citrinellus
ENSG00000131914LIN28A7373.750ENSACIG00000009818lin28b5879.310Amphilophus_citrinellus
ENSG00000131914LIN28A9872.816ENSAOCG00000021583si:ch1073-284b18.28979.310Amphiprion_ocellaris
ENSG00000131914LIN28A7376.623ENSAOCG00000015180lin28b7579.021Amphiprion_ocellaris
ENSG00000131914LIN28A8172.781ENSAOCG00000014049lin28a8370.175Amphiprion_ocellaris
ENSG00000131914LIN28A8272.515ENSAPEG00000007421lin28a7479.054Amphiprion_percula
ENSG00000131914LIN28A8072.024ENSAPEG00000021809LIN28B7579.021Amphiprion_percula
ENSG00000131914LIN28A9872.816ENSAPEG00000006197si:ch1073-284b18.28979.310Amphiprion_percula
ENSG00000131914LIN28A7376.623ENSAPEG00000021919lin28b7579.021Amphiprion_percula
ENSG00000131914LIN28A9873.301ENSATEG00000010132si:ch1073-284b18.28979.885Anabas_testudineus
ENSG00000131914LIN28A9365.842ENSATEG00000008862lin28a9465.842Anabas_testudineus
ENSG00000131914LIN28A7970.760ENSATEG00000014088lin28b8274.839Anabas_testudineus
ENSG00000131914LIN28A6486.466ENSACAG00000017764LIN28A9986.466Anolis_carolinensis
ENSG00000131914LIN28A8968.342ENSACAG00000003957LIN28B7467.172Anolis_carolinensis
ENSG00000131914LIN28A9972.596ENSANAG00000038124-9372.115Aotus_nancymaae
ENSG00000131914LIN28A10098.565ENSANAG00000021009-10098.565Aotus_nancymaae
ENSG00000131914LIN28A9375.897ENSANAG00000029599-9385.714Aotus_nancymaae
ENSG00000131914LIN28A9368.878ENSANAG00000036677-6972.881Aotus_nancymaae
ENSG00000131914LIN28A9766.010ENSANAG00000032418-7071.023Aotus_nancymaae
ENSG00000131914LIN28A7374.375ENSACLG00000021564lin28b6279.310Astatotilapia_calliptera
ENSG00000131914LIN28A9473.232ENSACLG00000027769si:ch1073-284b18.29472.222Astatotilapia_calliptera
ENSG00000131914LIN28A9970.142ENSAMXG00000042088si:ch1073-284b18.29969.668Astyanax_mexicanus
ENSG00000131914LIN28A7873.939ENSAMXG00000001433LIN28B6576.774Astyanax_mexicanus
ENSG00000131914LIN28A8970.745ENSAMXG00000038508lin28a9070.745Astyanax_mexicanus
ENSG00000131914LIN28A7768.323ENSAMXG00000001888lin28b7268.323Astyanax_mexicanus
ENSG00000131914LIN28A9980.383ENSBTAG00000048376-9978.947Bos_taurus
ENSG00000131914LIN28A10093.780ENSBTAG00000040497LIN28A10092.344Bos_taurus
ENSG00000131914LIN28A10088.038ENSBTAG00000048256-10086.603Bos_taurus
ENSG00000131914LIN28A7677.500ENSBTAG00000043973LIN28B6577.500Bos_taurus
ENSG00000131914LIN28A10089.952ENSCJAG00000021979-10089.952Callithrix_jacchus
ENSG00000131914LIN28A10092.823ENSCJAG00000022770-10092.823Callithrix_jacchus
ENSG00000131914LIN28A9989.320ENSCJAG00000046922-9389.320Callithrix_jacchus
ENSG00000131914LIN28A8672.928ENSCJAG00000001671LIN28B6477.987Callithrix_jacchus
ENSG00000131914LIN28A10099.043ENSCJAG00000009796LIN28A10099.043Callithrix_jacchus
ENSG00000131914LIN28A10094.762ENSCAFG00000012488LIN28A10094.762Canis_familiaris
ENSG00000131914LIN28A8572.067ENSCAFG00000003598LIN28B6377.707Canis_familiaris
ENSG00000131914LIN28A10094.762ENSCAFG00020021405LIN28A10094.762Canis_lupus_dingo
ENSG00000131914LIN28A8572.067ENSCAFG00020017606LIN28B6377.707Canis_lupus_dingo
ENSG00000131914LIN28A8274.566ENSCHIG00000011133LIN28B8373.295Capra_hircus
ENSG00000131914LIN28A10095.215ENSCHIG00000020597-10095.215Capra_hircus
ENSG00000131914LIN28A9777.228ENSCHIG00000026545-9275.743Capra_hircus
ENSG00000131914LIN28A8573.184ENSTSYG00000006480-6476.730Carlito_syrichta
ENSG00000131914LIN28A10096.651ENSTSYG00000027067LIN28A10096.651Carlito_syrichta
ENSG00000131914LIN28A8174.419ENSCAPG00000009019LIN28B6777.019Cavia_aperea
ENSG00000131914LIN28A7677.019ENSCPOG00000006178LIN28B6477.019Cavia_porcellus
ENSG00000131914LIN28A10094.258ENSCPOG00000024027-10094.258Cavia_porcellus
ENSG00000131914LIN28A10052.153ENSCPOG00000019646-10052.153Cavia_porcellus
ENSG00000131914LIN28A10098.565ENSCCAG00000012963-10098.565Cebus_capucinus
ENSG00000131914LIN28A10087.560ENSCCAG00000037041-10087.560Cebus_capucinus
ENSG00000131914LIN28A8573.184ENSCCAG00000020904LIN28B6972.881Cebus_capucinus
ENSG00000131914LIN28A10085.646ENSCCAG00000010683-10085.646Cebus_capucinus
ENSG00000131914LIN28A8572.626ENSCATG00000037900LIN28B6477.358Cercocebus_atys
ENSG00000131914LIN28A10099.043ENSCATG00000020825LIN28A10099.043Cercocebus_atys
ENSG00000131914LIN28A10094.737ENSCLAG00000013508LIN28A10094.737Chinchilla_lanigera
ENSG00000131914LIN28A8572.626ENSCLAG00000010534LIN28B6477.500Chinchilla_lanigera
ENSG00000131914LIN28A10098.571ENSCSAG00000000975LIN28A10098.571Chlorocebus_sabaeus
ENSG00000131914LIN28A6679.137ENSCSAG00000014708LIN28B7373.248Chlorocebus_sabaeus
ENSG00000131914LIN28A6270.543ENSCHOG00000001682LIN28B6377.273Choloepus_hoffmanni
ENSG00000131914LIN28A10064.115ENSCHOG00000002073-10063.636Choloepus_hoffmanni
ENSG00000131914LIN28A9982.212ENSCPBG00000025010LIN28A9982.212Chrysemys_picta_bellii
ENSG00000131914LIN28A8471.910ENSCPBG00000004104LIN28B6377.707Chrysemys_picta_bellii
ENSG00000131914LIN28A10097.608ENSCANG00000029848LIN28A10097.608Colobus_angolensis_palliatus
ENSG00000131914LIN28A10072.249ENSCANG00000039698-10067.464Colobus_angolensis_palliatus
ENSG00000131914LIN28A8572.626ENSCANG00000011024LIN28B6477.358Colobus_angolensis_palliatus
ENSG00000131914LIN28A7267.614ENSCGRG00001024078Lin28b6767.039Cricetulus_griseus_chok1gshd
ENSG00000131914LIN28A10095.215ENSCGRG00001017186Lin28a10095.215Cricetulus_griseus_chok1gshd
ENSG00000131914LIN28A7267.614ENSCGRG00000014674Lin28b6767.039Cricetulus_griseus_crigri
ENSG00000131914LIN28A10091.388ENSCGRG00000011390Lin28a10090.909Cricetulus_griseus_crigri
ENSG00000131914LIN28A10071.429ENSCSEG00000019091si:ch1073-284b18.210071.429Cynoglossus_semilaevis
ENSG00000131914LIN28A9661.033ENSCSEG00000000312lin28b7867.778Cynoglossus_semilaevis
ENSG00000131914LIN28A10071.429ENSCVAG00000017320si:ch1073-284b18.210070.000Cyprinodon_variegatus
ENSG00000131914LIN28A7373.585ENSCVAG00000001868lin28b6279.167Cyprinodon_variegatus
ENSG00000131914LIN28A9272.165ENSDARG00000004328LIN28A9175.145Danio_rerio
ENSG00000131914LIN28A10067.619ENSDARG00000016999lin28a8479.739Danio_rerio
ENSG00000131914LIN28A7871.779ENSDARG00000052511lin28b8368.571Danio_rerio
ENSG00000131914LIN28A8596.610ENSDNOG00000010710LIN28A8895.556Dasypus_novemcinctus
ENSG00000131914LIN28A8573.333ENSDNOG00000015300LIN28B6577.500Dasypus_novemcinctus
ENSG00000131914LIN28A9971.014ENSDNOG00000031694-9970.531Dasypus_novemcinctus
ENSG00000131914LIN28A10095.694ENSDORG00000027432Lin28a10095.694Dipodomys_ordii
ENSG00000131914LIN28A8572.626ENSDORG00000009587-6576.875Dipodomys_ordii
ENSG00000131914LIN28A10064.953ENSDORG00000005491-10064.486Dipodomys_ordii
ENSG00000131914LIN28A8570.391ENSDORG00000023330-6574.375Dipodomys_ordii
ENSG00000131914LIN28A9468.844ENSETEG00000015340LIN28B7072.626Echinops_telfairi
ENSG00000131914LIN28A7051.351ENSEBUG00000008325lin28a7649.359Eptatretus_burgeri
ENSG00000131914LIN28A8572.626ENSEASG00005006422LIN28B6577.500Equus_asinus_asinus
ENSG00000131914LIN28A10091.866ENSEASG00005003947LIN28A10090.431Equus_asinus_asinus
ENSG00000131914LIN28A8972.487ENSECAG00000020994LIN28B7272.487Equus_caballus
ENSG00000131914LIN28A10091.866ENSECAG00000020267LIN28A10090.431Equus_caballus
ENSG00000131914LIN28A10089.474ENSEEUG00000012085LIN28A10087.081Erinaceus_europaeus
ENSG00000131914LIN28A8572.222ENSEEUG00000003632LIN28B6476.875Erinaceus_europaeus
ENSG00000131914LIN28A8965.426ENSELUG00000001315lin28b7570.909Esox_lucius
ENSG00000131914LIN28A10070.476ENSELUG00000018033si:ch1073-284b18.210070.476Esox_lucius
ENSG00000131914LIN28A10068.571ENSELUG00000010131lin28a9968.571Esox_lucius
ENSG00000131914LIN28A10094.762ENSFCAG00000012810LIN28A10094.762Felis_catus
ENSG00000131914LIN28A7677.500ENSFCAG00000044308LIN28B6477.500Felis_catus
ENSG00000131914LIN28A8982.353ENSFALG00000000374LIN28A8684.358Ficedula_albicollis
ENSG00000131914LIN28A7373.333ENSFALG00000011574LIN28B7980.137Ficedula_albicollis
ENSG00000131914LIN28A8075.000ENSFDAG00000006141LIN28B6079.866Fukomys_damarensis
ENSG00000131914LIN28A10093.780ENSFDAG00000015707LIN28A10093.780Fukomys_damarensis
ENSG00000131914LIN28A7374.684ENSFHEG00000022590lin28b6278.472Fundulus_heteroclitus
ENSG00000131914LIN28A10073.333ENSFHEG00000001038si:ch1073-284b18.210071.905Fundulus_heteroclitus
ENSG00000131914LIN28A6779.856ENSGMOG00000015523lin28a9979.856Gadus_morhua
ENSG00000131914LIN28A8171.345ENSGMOG00000010704lin28b6277.931Gadus_morhua
ENSG00000131914LIN28A8975.000ENSGMOG00000015660si:ch1073-284b18.29476.111Gadus_morhua
ENSG00000131914LIN28A9981.731ENSGALG00000036022LIN28A9980.769Gallus_gallus
ENSG00000131914LIN28A8962.857ENSGALG00000026761LIN28B6377.070Gallus_gallus
ENSG00000131914LIN28A10070.952ENSGAFG00000008380si:ch1073-284b18.210070.952Gambusia_affinis
ENSG00000131914LIN28A9273.575ENSGACG00000013893si:ch1073-284b18.28877.222Gasterosteus_aculeatus
ENSG00000131914LIN28A8069.643ENSGACG00000007826lin28a9669.643Gasterosteus_aculeatus
ENSG00000131914LIN28A8270.690ENSGACG00000009428lin28b6178.621Gasterosteus_aculeatus
ENSG00000131914LIN28A9982.212ENSGAGG00000000401LIN28A9982.212Gopherus_agassizii
ENSG00000131914LIN28A8571.111ENSGAGG00000004857LIN28B6377.707Gopherus_agassizii
ENSG00000131914LIN28A10099.522ENSGGOG00000040223LIN28A10099.522Gorilla_gorilla
ENSG00000131914LIN28A10085.646ENSGGOG00000023305-10085.646Gorilla_gorilla
ENSG00000131914LIN28A8572.626ENSGGOG00000015437LIN28B6477.358Gorilla_gorilla
ENSG00000131914LIN28A8470.621ENSHBUG00000014195lin28b6279.310Haplochromis_burtoni
ENSG00000131914LIN28A9473.232ENSHBUG00000009265si:ch1073-284b18.29472.222Haplochromis_burtoni
ENSG00000131914LIN28A10083.732ENSHGLG00000013109-10083.732Heterocephalus_glaber_female
ENSG00000131914LIN28A8565.025ENSHGLG00000002468-6767.391Heterocephalus_glaber_female
ENSG00000131914LIN28A9381.959ENSHGLG00000001037-9181.461Heterocephalus_glaber_female
ENSG00000131914LIN28A7868.072ENSHGLG00000007160-6769.375Heterocephalus_glaber_female
ENSG00000131914LIN28A10079.904ENSHGLG00000008794-10078.947Heterocephalus_glaber_female
ENSG00000131914LIN28A10095.215ENSHGLG00000014608-10095.215Heterocephalus_glaber_female
ENSG00000131914LIN28A10084.211ENSHGLG00000019546-10084.211Heterocephalus_glaber_female
ENSG00000131914LIN28A9973.077ENSHGLG00100005396-9873.077Heterocephalus_glaber_male
ENSG00000131914LIN28A10094.258ENSHGLG00100017589-10094.258Heterocephalus_glaber_male
ENSG00000131914LIN28A7868.072ENSHGLG00100001729-6769.375Heterocephalus_glaber_male
ENSG00000131914LIN28A5366.423ENSHGLG00100014464-6666.423Heterocephalus_glaber_male
ENSG00000131914LIN28A10084.211ENSHGLG00100006225-10084.211Heterocephalus_glaber_male
ENSG00000131914LIN28A9476.263ENSHCOG00000006614si:ch1073-284b18.29872.038Hippocampus_comes
ENSG00000131914LIN28A7274.834ENSHCOG00000010844lin28b6375.333Hippocampus_comes
ENSG00000131914LIN28A9170.681ENSIPUG00000011583lin28a8476.829Ictalurus_punctatus
ENSG00000131914LIN28A7079.730ENSIPUG00000014304LIN28B7173.054Ictalurus_punctatus
ENSG00000131914LIN28A7666.875ENSIPUG00000013520lin28b8864.943Ictalurus_punctatus
ENSG00000131914LIN28A9572.222ENSIPUG00000014952si:ch1073-284b18.29470.707Ictalurus_punctatus
ENSG00000131914LIN28A8564.039ENSSTOG00000002692LIN28B6766.848Ictidomys_tridecemlineatus
ENSG00000131914LIN28A10080.476ENSSTOG00000022629-10080.476Ictidomys_tridecemlineatus
ENSG00000131914LIN28A10094.762ENSSTOG00000004329-10094.762Ictidomys_tridecemlineatus
ENSG00000131914LIN28A7476.282ENSJJAG00000011024Lin28b6976.282Jaculus_jaculus
ENSG00000131914LIN28A10078.947ENSJJAG00000000679-10078.947Jaculus_jaculus
ENSG00000131914LIN28A9491.878ENSJJAG00000018806Lin28a10091.878Jaculus_jaculus
ENSG00000131914LIN28A10071.429ENSKMAG00000013435si:ch1073-284b18.210071.429Kryptolebias_marmoratus
ENSG00000131914LIN28A9761.765ENSKMAG00000016334lin28b7079.167Kryptolebias_marmoratus
ENSG00000131914LIN28A9758.294ENSLBEG00000018630-9959.242Labrus_bergylta
ENSG00000131914LIN28A7374.375ENSLBEG00000019319lin28b5979.310Labrus_bergylta
ENSG00000131914LIN28A10070.476ENSLBEG00000027533si:ch1073-284b18.29770.476Labrus_bergylta
ENSG00000131914LIN28A9758.294ENSLBEG00000000893lin28a9959.242Labrus_bergylta
ENSG00000131914LIN28A8670.492ENSLACG00000004053LIN28B5974.699Latimeria_chalumnae
ENSG00000131914LIN28A9975.362ENSLACG00000002747LIN28A9876.098Latimeria_chalumnae
ENSG00000131914LIN28A10075.355ENSLOCG00000003353lin28a10074.408Lepisosteus_oculatus
ENSG00000131914LIN28A7477.707ENSLOCG00000016539lin28b6477.707Lepisosteus_oculatus
ENSG00000131914LIN28A10092.823ENSLAFG00000017525LIN28A10091.866Loxodonta_africana
ENSG00000131914LIN28A8472.727ENSLAFG00000017788LIN28B6278.065Loxodonta_africana
ENSG00000131914LIN28A10099.043ENSMFAG00000037808LIN28A10099.043Macaca_fascicularis
ENSG00000131914LIN28A8572.626ENSMFAG00000013463LIN28B6477.358Macaca_fascicularis
ENSG00000131914LIN28A8572.626ENSMMUG00000014470LIN28B6477.358Macaca_mulatta
ENSG00000131914LIN28A10099.043ENSMMUG00000044953LIN28A10099.043Macaca_mulatta
ENSG00000131914LIN28A10098.565ENSMNEG00000035868LIN28A10098.565Macaca_nemestrina
ENSG00000131914LIN28A8572.626ENSMNEG00000038148LIN28B6477.358Macaca_nemestrina
ENSG00000131914LIN28A8572.626ENSMLEG00000028886LIN28B6477.358Mandrillus_leucophaeus
ENSG00000131914LIN28A10099.043ENSMLEG00000011746LIN28A10099.043Mandrillus_leucophaeus
ENSG00000131914LIN28A8172.353ENSMAMG00000006635lin28b6580.000Mastacembelus_armatus
ENSG00000131914LIN28A9965.877ENSMAMG00000002030lin28a9965.403Mastacembelus_armatus
ENSG00000131914LIN28A9873.786ENSMAMG00000007271si:ch1073-284b18.29079.545Mastacembelus_armatus
ENSG00000131914LIN28A7374.375ENSMZEG00005018178lin28b6279.310Maylandia_zebra
ENSG00000131914LIN28A9473.232ENSMZEG00005006914si:ch1073-284b18.29472.222Maylandia_zebra
ENSG00000131914LIN28A9978.641ENSMGAG00000009456LIN28A8785.475Meleagris_gallopavo
ENSG00000131914LIN28A5465.789ENSMGAG00000013531LIN28B6265.789Meleagris_gallopavo
ENSG00000131914LIN28A8538.674ENSMAUG00000006523Lin28b5339.130Mesocricetus_auratus
ENSG00000131914LIN28A10095.215ENSMAUG00000018852Lin28a10095.215Mesocricetus_auratus
ENSG00000131914LIN28A8075.000ENSMICG00000047923LIN28B6178.947Microcebus_murinus
ENSG00000131914LIN28A10086.603ENSMICG00000034716-10086.124Microcebus_murinus
ENSG00000131914LIN28A10091.866ENSMICG00000035289-10091.866Microcebus_murinus
ENSG00000131914LIN28A10088.517ENSMICG00000013694-10087.081Microcebus_murinus
ENSG00000131914LIN28A9298.446ENSMICG00000035023-10098.446Microcebus_murinus
ENSG00000131914LIN28A10095.215ENSMOCG00000007819Lin28a10095.215Microtus_ochrogaster
ENSG00000131914LIN28A8572.626ENSMOCG00000015558Lin28b6477.358Microtus_ochrogaster
ENSG00000131914LIN28A8069.461ENSMMOG00000014314lin28a9069.461Mola_mola
ENSG00000131914LIN28A6974.150ENSMMOG00000014877lin28b5174.150Mola_mola
ENSG00000131914LIN28A9473.737ENSMMOG00000002137si:ch1073-284b18.29173.737Mola_mola
ENSG00000131914LIN28A7363.684ENSMODG00000018035LIN28B6563.212Monodelphis_domestica
ENSG00000131914LIN28A10091.388ENSMODG00000014236LIN28A10089.474Monodelphis_domestica
ENSG00000131914LIN28A7374.684ENSMALG00000000365lin28b6379.310Monopterus_albus
ENSG00000131914LIN28A9463.184ENSMALG00000004941lin28a8869.822Monopterus_albus
ENSG00000131914LIN28A9873.301ENSMALG00000012505si:ch1073-284b18.29873.301Monopterus_albus
ENSG00000131914LIN28A10096.172MGP_CAROLIEiJ_G0026603Lin28a100100.000Mus_caroli
ENSG00000131914LIN28A8565.517MGP_CAROLIEiJ_G0015299Lin28b6868.852Mus_caroli
ENSG00000131914LIN28A8565.517ENSMUSG00000063804Lin28b6868.852Mus_musculus
ENSG00000131914LIN28A10096.651ENSMUSG00000050966Lin28a100100.000Mus_musculus
ENSG00000131914LIN28A9096.296MGP_PahariEiJ_G0028936Lin28a10098.667Mus_pahari
ENSG00000131914LIN28A8565.025MGP_PahariEiJ_G0030716Lin28b6868.306Mus_pahari
ENSG00000131914LIN28A10096.651MGP_SPRETEiJ_G0027583Lin28a100100.000Mus_spretus
ENSG00000131914LIN28A8565.517MGP_SPRETEiJ_G0016108Lin28b6868.852Mus_spretus
ENSG00000131914LIN28A10094.286ENSMPUG00000015724LIN28A10092.857Mustela_putorius_furo
ENSG00000131914LIN28A8572.626ENSMPUG00000009489LIN28B6476.875Mustela_putorius_furo
ENSG00000131914LIN28A10093.301ENSMLUG00000010158-10091.866Myotis_lucifugus
ENSG00000131914LIN28A5480.702ENSMLUG00000006883LIN28B6280.702Myotis_lucifugus
ENSG00000131914LIN28A10096.172ENSNGAG00000018842Lin28a10096.172Nannospalax_galili
ENSG00000131914LIN28A8274.138ENSNGAG00000022808Lin28b6578.750Nannospalax_galili
ENSG00000131914LIN28A9472.727ENSNBRG00000009446si:ch1073-284b18.29471.717Neolamprologus_brichardi
ENSG00000131914LIN28A7374.375ENSNBRG00000020118lin28b6079.310Neolamprologus_brichardi
ENSG00000131914LIN28A10089.952ENSNLEG00000030680-10088.995Nomascus_leucogenys
ENSG00000131914LIN28A10084.211ENSNLEG00000027494-10084.211Nomascus_leucogenys
ENSG00000131914LIN28A8572.067ENSNLEG00000014146LIN28B6972.316Nomascus_leucogenys
ENSG00000131914LIN28A10098.086ENSNLEG00000028132LIN28A10098.086Nomascus_leucogenys
ENSG00000131914LIN28A7764.417ENSMEUG00000003066LIN28B6565.625Notamacropus_eugenii
ENSG00000131914LIN28A10090.909ENSMEUG00000008743LIN28A10088.995Notamacropus_eugenii
ENSG00000131914LIN28A8374.286ENSOPRG00000006333LIN28B7074.286Ochotona_princeps
ENSG00000131914LIN28A10095.694ENSOPRG00000001591LIN28A10095.694Ochotona_princeps
ENSG00000131914LIN28A9992.271ENSODEG00000004283-10092.271Octodon_degus
ENSG00000131914LIN28A8572.067ENSODEG00000013568LIN28B6476.875Octodon_degus
ENSG00000131914LIN28A10092.344ENSODEG00000019263-10092.344Octodon_degus
ENSG00000131914LIN28A10071.429ENSODEG00000016070-10071.429Octodon_degus
ENSG00000131914LIN28A6179.845ENSONIG00000014706lin28b6779.845Oreochromis_niloticus
ENSG00000131914LIN28A9473.232ENSONIG00000016204si:ch1073-284b18.29472.222Oreochromis_niloticus
ENSG00000131914LIN28A7378.710ENSOANG00000010299LIN28B6677.848Ornithorhynchus_anatinus
ENSG00000131914LIN28A10096.172ENSOCUG00000027473-10096.172Oryctolagus_cuniculus
ENSG00000131914LIN28A6679.137ENSOCUG00000017850LIN28B6679.137Oryctolagus_cuniculus
ENSG00000131914LIN28A10056.190ENSOCUG00000022420-10056.667Oryctolagus_cuniculus
ENSG00000131914LIN28A10091.388ENSOCUG00000027786-10090.909Oryctolagus_cuniculus
ENSG00000131914LIN28A10096.172ENSOCUG00000000299-10096.172Oryctolagus_cuniculus
ENSG00000131914LIN28A8686.667ENSOCUG00000011640-10086.667Oryctolagus_cuniculus
ENSG00000131914LIN28A9166.837ENSORLG00000012891lin28b6475.817Oryzias_latipes
ENSG00000131914LIN28A10069.524ENSORLG00000028106si:ch1073-284b18.210069.524Oryzias_latipes
ENSG00000131914LIN28A10069.524ENSORLG00020019710si:ch1073-284b18.210069.524Oryzias_latipes_hni
ENSG00000131914LIN28A8569.444ENSORLG00020013527lin28b6475.817Oryzias_latipes_hni
ENSG00000131914LIN28A8569.444ENSORLG00015008232lin28b6475.817Oryzias_latipes_hsok
ENSG00000131914LIN28A10070.000ENSORLG00015004663si:ch1073-284b18.210070.000Oryzias_latipes_hsok
ENSG00000131914LIN28A10069.524ENSOMEG00000018521si:ch1073-284b18.210070.000Oryzias_melastigma
ENSG00000131914LIN28A7671.875ENSOMEG00000006425lin28b6774.000Oryzias_melastigma
ENSG00000131914LIN28A10097.129ENSOGAG00000003971LIN28A10097.129Otolemur_garnettii
ENSG00000131914LIN28A8671.978ENSOGAG00000011042LIN28B6478.125Otolemur_garnettii
ENSG00000131914LIN28A7677.500ENSOARG00000011404LIN28B5977.500Ovis_aries
ENSG00000131914LIN28A10088.038ENSOARG00000004614LIN28A10088.517Ovis_aries
ENSG00000131914LIN28A9986.957ENSOARG00000003913-10085.507Ovis_aries
ENSG00000131914LIN28A10099.043ENSPPAG00000037906LIN28A10099.043Pan_paniscus
ENSG00000131914LIN28A9368.528ENSPPAG00000038725LIN28B7273.248Pan_paniscus
ENSG00000131914LIN28A10088.038ENSPPAG00000012576-10088.038Pan_paniscus
ENSG00000131914LIN28A10094.762ENSPPRG00000009198LIN28A10094.762Panthera_pardus
ENSG00000131914LIN28A7677.500ENSPPRG00000016158LIN28B6477.500Panthera_pardus
ENSG00000131914LIN28A8373.295ENSPTIG00000009405LIN28B6577.500Panthera_tigris_altaica
ENSG00000131914LIN28A8896.196ENSPTIG00000015007LIN28A8896.196Panthera_tigris_altaica
ENSG00000131914LIN28A10099.522ENSPTRG00000000384LIN28A10099.522Pan_troglodytes
ENSG00000131914LIN28A10087.560ENSPTRG00000049314-10087.560Pan_troglodytes
ENSG00000131914LIN28A9368.528ENSPTRG00000018453LIN28B6972.316Pan_troglodytes
ENSG00000131914LIN28A8672.376ENSPANG00000032324-6477.358Papio_anubis
ENSG00000131914LIN28A8572.626ENSPANG00000005196-6772.316Papio_anubis
ENSG00000131914LIN28A10098.565ENSPANG00000009841LIN28A10098.565Papio_anubis
ENSG00000131914LIN28A9572.000ENSPKIG00000004532lin28a9175.843Paramormyrops_kingsleyae
ENSG00000131914LIN28A6981.507ENSPKIG00000013309lin28b6081.507Paramormyrops_kingsleyae
ENSG00000131914LIN28A7676.398ENSPSIG00000002635LIN28B6377.707Pelodiscus_sinensis
ENSG00000131914LIN28A6389.394ENSPSIG00000018001LIN28A8788.722Pelodiscus_sinensis
ENSG00000131914LIN28A7472.903ENSPMGG00000022825lin28b5572.903Periophthalmus_magnuspinnatus
ENSG00000131914LIN28A8469.318ENSPMGG00000003595-7480.142Periophthalmus_magnuspinnatus
ENSG00000131914LIN28A9970.388ENSPMGG00000004200si:ch1073-284b18.29275.568Periophthalmus_magnuspinnatus
ENSG00000131914LIN28A8573.743ENSPEMG00000015724Lin28b6477.987Peromyscus_maniculatus_bairdii
ENSG00000131914LIN28A10094.258ENSPEMG00000012419Lin28a10094.258Peromyscus_maniculatus_bairdii
ENSG00000131914LIN28A10091.388ENSPCIG00000012691LIN28A10089.474Phascolarctos_cinereus
ENSG00000131914LIN28A7772.671ENSPFOG00000019352lin28b6177.778Poecilia_formosa
ENSG00000131914LIN28A10070.952ENSPFOG00000014054si:ch1073-284b18.210070.952Poecilia_formosa
ENSG00000131914LIN28A7772.671ENSPLAG00000009101lin28b6177.778Poecilia_latipinna
ENSG00000131914LIN28A10070.952ENSPLAG00000020857si:ch1073-284b18.210070.952Poecilia_latipinna
ENSG00000131914LIN28A8368.182ENSPMEG00000015694lin28b6177.778Poecilia_mexicana
ENSG00000131914LIN28A10071.429ENSPMEG00000013212si:ch1073-284b18.210071.429Poecilia_mexicana
ENSG00000131914LIN28A10070.952ENSPREG00000005259si:ch1073-284b18.210070.952Poecilia_reticulata
ENSG00000131914LIN28A10099.043ENSPPYG00000001684LIN28A10099.043Pongo_abelii
ENSG00000131914LIN28A8472.472ENSPPYG00000016875LIN28B6577.358Pongo_abelii
ENSG00000131914LIN28A10089.474ENSPCAG00000013674LIN28A10088.995Procavia_capensis
ENSG00000131914LIN28A8373.563ENSPCOG00000016875LIN28B6278.571Propithecus_coquereli
ENSG00000131914LIN28A10097.608ENSPCOG00000026551-10097.608Propithecus_coquereli
ENSG00000131914LIN28A10077.512ENSPCOG00000016166-10075.598Propithecus_coquereli
ENSG00000131914LIN28A10086.124ENSPCOG00000019441-10085.167Propithecus_coquereli
ENSG00000131914LIN28A8571.508ENSPVAG00000008797LIN28B5876.250Pteropus_vampyrus
ENSG00000131914LIN28A9793.596ENSPVAG00000017267LIN28A9096.667Pteropus_vampyrus
ENSG00000131914LIN28A9473.232ENSPNYG00000014005si:ch1073-284b18.28780.952Pundamilia_nyererei
ENSG00000131914LIN28A7374.375ENSPNYG00000022590lin28b6079.310Pundamilia_nyererei
ENSG00000131914LIN28A9771.078ENSPNAG00000015739si:ch1073-284b18.29771.078Pygocentrus_nattereri
ENSG00000131914LIN28A7172.667ENSPNAG00000002632lin28b7272.667Pygocentrus_nattereri
ENSG00000131914LIN28A7478.065ENSPNAG00000016114LIN28B6278.065Pygocentrus_nattereri
ENSG00000131914LIN28A9667.327ENSPNAG00000019008lin28a9666.832Pygocentrus_nattereri
ENSG00000131914LIN28A10098.086ENSRNOG00000060320Lin28a10098.086Rattus_norvegicus
ENSG00000131914LIN28A8573.889ENSRNOG00000025938Lin28b6578.125Rattus_norvegicus
ENSG00000131914LIN28A10079.904ENSRBIG00000011346-10079.904Rhinopithecus_bieti
ENSG00000131914LIN28A10098.086ENSRBIG00000032004LIN28A10098.086Rhinopithecus_bieti
ENSG00000131914LIN28A8572.626ENSRBIG00000036241LIN28B6477.358Rhinopithecus_bieti
ENSG00000131914LIN28A8572.626ENSRROG00000033602LIN28B6477.358Rhinopithecus_roxellana
ENSG00000131914LIN28A10098.086ENSRROG00000013874LIN28A10098.086Rhinopithecus_roxellana
ENSG00000131914LIN28A10079.904ENSRROG00000032651-10079.904Rhinopithecus_roxellana
ENSG00000131914LIN28A10083.254ENSSBOG00000031930-10083.254Saimiri_boliviensis_boliviensis
ENSG00000131914LIN28A8097.619ENSSBOG00000005545-10097.619Saimiri_boliviensis_boliviensis
ENSG00000131914LIN28A8573.184ENSSBOG00000025323LIN28B6972.881Saimiri_boliviensis_boliviensis
ENSG00000131914LIN28A10093.301ENSSBOG00000033280-10093.301Saimiri_boliviensis_boliviensis
ENSG00000131914LIN28A5480.000ENSSHAG00000012716-6280.000Sarcophilus_harrisii
ENSG00000131914LIN28A7079.592ENSSFOG00015010561lin28b5579.333Scleropages_formosus
ENSG00000131914LIN28A9076.842ENSSFOG00015006164lin28a9972.727Scleropages_formosus
ENSG00000131914LIN28A6975.862ENSSMAG00000020241lin28a9467.039Scophthalmus_maximus
ENSG00000131914LIN28A9871.845ENSSMAG00000005221si:ch1073-284b18.29871.845Scophthalmus_maximus
ENSG00000131914LIN28A8570.621ENSSDUG00000011644lin28a9068.927Seriola_dumerili
ENSG00000131914LIN28A8874.054ENSSDUG00000009722si:ch1073-284b18.29476.966Seriola_dumerili
ENSG00000131914LIN28A6979.310ENSSDUG00000000613lin28b6379.310Seriola_dumerili
ENSG00000131914LIN28A9765.094ENSSLDG00000020568lin28a9471.111Seriola_lalandi_dorsalis
ENSG00000131914LIN28A8470.455ENSSLDG00000001858lin28b6279.310Seriola_lalandi_dorsalis
ENSG00000131914LIN28A8677.473ENSSLDG00000003150si:ch1073-284b18.28978.613Seriola_lalandi_dorsalis
ENSG00000131914LIN28A6675.182ENSSARG00000013135-10072.993Sorex_araneus
ENSG00000131914LIN28A8571.508ENSSARG00000008374LIN28B6477.358Sorex_araneus
ENSG00000131914LIN28A8666.154ENSSPUG00000013225LIN28B6971.591Sphenodon_punctatus
ENSG00000131914LIN28A9982.212ENSSPUG00000010213LIN28A9982.212Sphenodon_punctatus
ENSG00000131914LIN28A8170.414ENSSPAG00000018737lin28a7877.703Stegastes_partitus
ENSG00000131914LIN28A7376.623ENSSPAG00000009877lin28b6379.310Stegastes_partitus
ENSG00000131914LIN28A9873.301ENSSPAG00000012590si:ch1073-284b18.29873.301Stegastes_partitus
ENSG00000131914LIN28A8671.823ENSSSCG00000037612LIN28B6176.875Sus_scrofa
ENSG00000131914LIN28A8963.441ENSSSCG00000039310-8063.889Sus_scrofa
ENSG00000131914LIN28A10093.780ENSSSCG00000003557LIN28A10092.344Sus_scrofa
ENSG00000131914LIN28A10055.981ENSSSCG00000039497-10055.502Sus_scrofa
ENSG00000131914LIN28A6488.722ENSTGUG00000001037LIN28A9988.722Taeniopygia_guttata
ENSG00000131914LIN28A7771.839ENSTGUG00000012225LIN28B6377.707Taeniopygia_guttata
ENSG00000131914LIN28A9871.359ENSTRUG00000006069si:ch1073-284b18.29871.359Takifugu_rubripes
ENSG00000131914LIN28A5752.000ENSTRUG00000009454lin28a5756.481Takifugu_rubripes
ENSG00000131914LIN28A8566.492ENSTRUG00000019692lin28b7769.492Takifugu_rubripes
ENSG00000131914LIN28A6773.050ENSTNIG00000009802lin28a8573.050Tetraodon_nigroviridis
ENSG00000131914LIN28A6979.452ENSTNIG00000012302lin28b6379.452Tetraodon_nigroviridis
ENSG00000131914LIN28A8373.563ENSTTRG00000014919LIN28B5678.065Tursiops_truncatus
ENSG00000131914LIN28A9194.241ENSTTRG00000005678LIN28A9395.000Tursiops_truncatus
ENSG00000131914LIN28A10094.286ENSUAMG00000006984LIN28A10092.857Ursus_americanus
ENSG00000131914LIN28A8573.184ENSUAMG00000022834LIN28B6477.500Ursus_americanus
ENSG00000131914LIN28A8573.184ENSUMAG00000020916LIN28B6477.500Ursus_maritimus
ENSG00000131914LIN28A10094.286ENSUMAG00000012579LIN28A10092.857Ursus_maritimus
ENSG00000131914LIN28A6094.444ENSVPAG00000008073LIN28A10094.444Vicugna_pacos
ENSG00000131914LIN28A8464.607ENSVPAG00000011202LIN28B6568.125Vicugna_pacos
ENSG00000131914LIN28A10094.286ENSVVUG00000011926-10092.857Vulpes_vulpes
ENSG00000131914LIN28A8770.109ENSVVUG00000003739LIN28B6377.707Vulpes_vulpes
ENSG00000131914LIN28A10089.048ENSVVUG00000010329-10088.095Vulpes_vulpes
ENSG00000131914LIN28A8972.043ENSVVUG00000013087-6774.719Vulpes_vulpes
ENSG00000131914LIN28A8654.348ENSXETG00000013293lin28b6358.750Xenopus_tropicalis
ENSG00000131914LIN28A9567.839ENSXETG00000012324lin28a9767.839Xenopus_tropicalis
ENSG00000131914LIN28A10071.429ENSXCOG00000000815si:ch1073-284b18.210071.429Xiphophorus_couchianus
ENSG00000131914LIN28A7176.000ENSXCOG00000004261lin28b6276.000Xiphophorus_couchianus
ENSG00000131914LIN28A10071.429ENSXMAG00000014593si:ch1073-284b18.210071.429Xiphophorus_maculatus
ENSG00000131914LIN28A6878.472ENSXMAG00000003450lin28b6178.472Xiphophorus_maculatus
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0000932P-body17617744.IDAComponent
GO:0002151G-quadruplex RNA binding-ISSFunction
GO:0003723RNA binding18951094.19703396.IDAFunction
GO:0005515protein binding19703396.21247876.IPIFunction
GO:0005634nucleus17617744.IDAComponent
GO:0005730nucleolus-IEAComponent
GO:0005737cytoplasm18604195.20014101.IDAComponent
GO:0005791rough endoplasmic reticulum-ISSComponent
GO:0005829cytosol-TASComponent
GO:0005844polysome21247876.IDAComponent
GO:0007281germ cell development-IEAProcess
GO:0008270zinc ion binding-IEAFunction
GO:0010494cytoplasmic stress granule17617744.IDAComponent
GO:0010587miRNA catabolic process18951094.19703396.IMPProcess
GO:0017148negative regulation of translation-ISSProcess
GO:0019827stem cell population maintenance19703396.IMPProcess
GO:0031054pre-miRNA processing18951094.19703396.IMPProcess
GO:0031123RNA 3'-end processing18951094.19703396.IMPProcess
GO:0031369translation initiation factor binding-IEAFunction
GO:0032008positive regulation of TOR signaling-ISSProcess
GO:0035019somatic stem cell population maintenance-TASProcess
GO:0035198miRNA binding-ISSFunction
GO:0045666positive regulation of neuron differentiation-IEAProcess
GO:0045686negative regulation of glial cell differentiation-IEAProcess
GO:0048863stem cell differentiation-IEAProcess
GO:0051897positive regulation of protein kinase B signaling-ISSProcess
GO:0071333cellular response to glucose stimulus-ISSProcess
GO:1901724positive regulation of cell proliferation involved in kidney development-IEAProcess
GO:1903800positive regulation of production of miRNAs involved in gene silencing by miRNA-ISSProcess
GO:1905538polysome binding21247876.IDAFunction
GO:1990825sequence-specific mRNA binding-ISSFunction
GO:1990904ribonucleoprotein complex21247876.IDAComponent
GO:2000767positive regulation of cytoplasmic translation21247876.IMPProcess
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