EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
25652936	CAP1 is overexpressed in human epithelial ovarian cancer and promotes cell proliferation.	Int J Mol Med	2015 Apr	Hua M	doi: 10.3892/ijmm.2015.2089
25371324	Overexpression of adenylate cyclase-associated protein 1 may predict brain metastasis in non-small cell lung cancer.	Oncol Rep	2015 Jan	Xie SS	doi: 10.3892/or.2014.3577
23842884	Overexpression of adenylate cyclase-associated protein 1 is associated with metastasis of lung cancer.	Oncol Rep	2013 Oct	Tan M	doi: 10.3892/or.2013.2607
19188911	Adenylate cyclase-associated protein 1 overexpressed in pancreatic cancers is involved in cancer cell motility.	Lab Invest	2009 Apr	Yamazaki K	doi: 10.1038/labinvest.2009.5
27173014	CAP1 (Cyclase-Associated Protein 1) Exerts Distinct Functions in the Proliferation and Metastatic Potential of Breast Cancer Cells Mediated by ERK.	Sci Rep	2016 May 13	Zhang H	doi: 10.1038/srep25933.
29641286	Association of RETN and CAP1 SNPs, Expression and Serum Resistin Levels with Breast Cancer in Mexican Women.	Genet Test Mol Biomarkers	2018 Apr	Muoz-Palomeque A	doi: 10.1089/gtmb.2017.0212

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr1	40066248	Nonsense_Mutation	novel	Y186*	0.16
BLCA	chr1	40070936	Missense_Mutation	NA	S434F	0.05
BLCA	chr1	40064295	Missense_Mutation	novel	K121N	0.55
BLCA	chr1	40060082	Missense_Mutation	NA	Y43C	0.42
BLCA	chr1	40071476	Missense_Mutation	NA	F457L	0.58
BLCA	chr1	40064258	Nonsense_Mutation	NA	S109*	0.22
BLCA	chr1	40070946	Missense_Mutation	novel	M437I	0.2
BLCA	chr1	40059413	Missense_Mutation	novel	H23Y	0.22
BRCA	chr1	40064533	Missense_Mutation	NA	N166K	0.2
BRCA	chr1	40072341	3'Flank	novel		0.26
BRCA	chr1	40059431	Missense_Mutation	NA	R29G	0.44
BRCA	chr1	40070922	Frame_Shift_Del	NA	*S431Pfs6**	0.16
CESC	chr1	40072361	3'Flank	novel		0.45
CESC	chr1	40061768	Nonsense_Mutation	novel	R84*	0.37
CESC	chr1	40071473	Frame_Shift_Ins	novel	*K458Qfs?**	0.24
CESC	chr1	40040586	5'Flank	novel		0.5
CESC	chr1	40070510	Missense_Mutation	NA	Q400E	0.31
COAD	chr1	40064299	Silent	NA	R123R	0.16
COAD	chr1	40071594	3'Flank	rs185160226		0.16
COAD	chr1	40071492	Missense_Mutation	NA	G463R	0.3
COAD	chr1	40071463	Missense_Mutation	NA	V453A	0.18
COAD	chr1	40067555	Nonsense_Mutation	NA	E216*	0.31
COAD	chr1	40070941	Missense_Mutation	rs374359120	E436K	0.18
COAD	chr1	40064296	In_Frame_Ins	novel	N122delinsIQEKIH	0.06
HNSC	chr1	40069762	Missense_Mutation	rs35749351	R294H	0.22
HNSC	chr1	40070464	Silent	rs749068331	D384D	0.23
HNSC	chr1	40071498	Missense_Mutation	novel	K465Q	0.26
HNSC	chr1	40060100	Missense_Mutation	rs765357509	S49L	0.31
HNSC	chr1	40070431	Frame_Shift_Del	novel	*N374Gfs4**	0.23
HNSC	chr1	40059376	Missense_Mutation	novel	R10S	0.24
KICH	chr1	40071492	Missense_Mutation	NA	G463R	0.12
KIRP	chr1	40070873	Missense_Mutation	NA	T413I	0.38
LGG	chr1	40064517	Frame_Shift_Ins	novel	*M162Vfs17**	0.06
LUSC	chr1	40069754	Silent	rs373976739	G291G	0.11
LUSC	chr1	40067563	Silent	rs569531431	S218S	0.73
LUSC	chr1	40064345	Missense_Mutation	NA	I138T	0.77
OV	chr1	40069729	Missense_Mutation	novel	N283S	0.05
OV	chr1	40071606	3'Flank	novel		0.34
OV	chr1	40064504	Missense_Mutation	NA	M157V	0.34
OV	chr1	40066250	Frame_Shift_Ins	novel	*L187Ffs20**	0.15
PRAD	chr1	40069779	Frame_Shift_Del	novel	*F300Sfs42**	0.16
READ	chr1	40071519	Nonsense_Mutation	novel	E472*	0.05
READ	chr1	40066301	Missense_Mutation	NA	G204E	0.56
READ	chr1	40070970	Silent	NA	G445G	0.32
SARC	chr1	40040682	5'Flank	novel		0.3
SKCM	chr1	40059453	Missense_Mutation	rs758617435	S36L	0.43
SKCM	chr1	40064238	Silent	rs777626332	S102S	0.54
SKCM	chr1	40067617	Silent	novel	C236C	0.17
STAD	chr1	40070459	Missense_Mutation	NA	D383N	0.13
STAD	chr1	40064242	Missense_Mutation	NA	L104M	0.07
STAD	chr1	40070482	Missense_Mutation	novel	E390D	0.47
STAD	chr1	40064283	Silent	novel	T117T	0.18
STAD	chr1	40067587	Silent	rs201296194	A226A	0.26
STAD	chr1	40071535	3'UTR	rs777378618		0.3
STAD	chr1	40069755	Missense_Mutation	rs781671919	P292T	0.11
STAD	chr1	40059404	Missense_Mutation	NA	A20T	0.25
STAD	chr1	40070222	Missense_Mutation	NA	I353L	0.35
UCEC	chr1	40066242	Missense_Mutation	NA	K184N	0.29
UCEC	chr1	40066290	Missense_Mutation	rs749520906	F200L	0.26
UCEC	chr1	40071984	3'Flank	novel		0.27
UCEC	chr1	40069819	Missense_Mutation	rs377554241	R313Q	0.37
UCEC	chr1	40070158	Splice_Site	novel	X332_splice	0.72
UCEC	chr1	40061736	Missense_Mutation	rs776999876	A73V	0.38
UCEC	chr1	40070165	Nonsense_Mutation	NA	Q334*	0.21
UCEC	chr1	40070242	Silent	rs376842925	T359T	0.25
UCEC	chr1	40064354	Missense_Mutation	NA	L141R	0.51
UCEC	chr1	40069829	Silent	novel	K316K	0.22
UCEC	chr1	40069856	Missense_Mutation	NA	E325D	0.45
UCEC	chr1	40070901	Missense_Mutation	novel	K422N	0.52
UCEC	chr1	40071552	3'Flank	novel		0.24
UCEC	chr1	40071837	3'Flank	novel		0.37
UCEC	chr1	40072347	3'Flank	novel		0.3
UCEC	chr1	40069771	Missense_Mutation	NA	P297L	0.23
UCEC	chr1	40064288	Missense_Mutation	novel	R119Q	0.35
UCEC	chr1	40069716	Missense_Mutation	novel	K279Q	0.41
UCEC	chr1	40070890	Missense_Mutation	novel	Y419H	0.52
UCEC	chr1	40072528	3'Flank	novel		0.35
UCEC	chr1	40070253	Missense_Mutation	novel	I363S	0.19
UCEC	chr1	40069876	Splice_Site	novel	X331_splice	0.27
UCEC	chr1	40072387	3'Flank	novel		0.44
UCEC	chr1	40070933	Frame_Shift_Ins	novel	*S434Yfs5**	0.08
UCEC	chr1	40070934	Missense_Mutation	novel	K433N	0.08
UCEC	chr1	40071599	3'Flank	novel		0.33
UCEC	chr1	40064501	Nonsense_Mutation	NA	E156*	0.29
UCEC	chr1	40069778	Silent	novel	P299P	0.22
UCEC	chr1	40072528	3'Flank	novel		0.39
UCEC	chr1	40069797	Missense_Mutation	NA	Q306K	0.08
UCEC	chr1	40064338	Missense_Mutation	novel	E136K	0.37
UCEC	chr1	40071599	3'Flank	novel		0.34
UCEC	chr1	40071652	3'Flank	novel		0.42
UCEC	chr1	40072527	3'Flank	rs773042885		0.36
UCEC	chr1	40067555	Nonsense_Mutation	NA	E216*	0.17
UCEC	chr1	40040659	5'Flank	novel		0.35
UCEC	chr1	40071770	3'Flank	novel		0.44
UCEC	chr1	40072305	3'Flank	novel		0.6
UCEC	chr1	40071877	3'Flank	novel		0.28
UCEC	chr1	40072425	3'Flank	novel		0.6
UCEC	chr1	40061751	Missense_Mutation	rs766562094	T78I	0.18
UCEC	chr1	40070439	Missense_Mutation	novel	K376T	0.07
UCEC	chr1	40066245	Silent	novel	A185A	0.3
UCEC	chr1	40071711	3'Flank	novel		0.4

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
BLCA	AMP	0.1838	9.7487e-09
DLBC	DEL	0.0833	0.011841
ESCA	AMP	0.1739	0.0024624
LUAD	AMP	0.1783	0.040181
PAAD	AMP	0.0217	0.22288
TGCT	DEL	0.1467	0.00046313

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.00018	Kaplan-Meier Survival Analysis
MESO	0.00056	Kaplan-Meier Survival Analysis
ACC	0.016	Kaplan-Meier Survival Analysis
SKCM	0.00096	Kaplan-Meier Survival Analysis
LUSC	0.014	Kaplan-Meier Survival Analysis
COAD	0.047	Kaplan-Meier Survival Analysis
PAAD	0.014	Kaplan-Meier Survival Analysis
CESC	0.00025	Kaplan-Meier Survival Analysis
LAML	0.0001	Kaplan-Meier Survival Analysis
KICH	0.032	Kaplan-Meier Survival Analysis
LIHC	0.00016	Kaplan-Meier Survival Analysis
LGG	0.0001	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Expression

Transcripts

Gene Model

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000131236 (Gene tree)
Gene ID: 10487
Gene Symbol: CAP1
Alias: CAP
Full Name: cyclase associated actin cytoskeleton regulatory protein 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 32,417 bases
Position: chr1:40,040,233-40,072,649
Accession: 20040
RBP type: non-canonical RBP
Summary: The protein encoded by this gene is related to the S. cerevisiae CAP protein, which is involved in the cyclic AMP pathway. The human protein is able to interact with other molecules of the same protein, as well as with CAP2 and actin. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2016]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000417287	CAP1-209	610	-	ENSP00000400943	176 (aa)	-	Q5T0R6
ENST00000435719	CAP1-214	817	-	ENSP00000412859	262 (aa)	-	Q5T0R9
ENST00000479759	CAP1-218	888	-	-	- (aa)	-	-
ENST00000494114	CAP1-219	744	-	-	- (aa)	-	-
ENST00000424977	CAP1-212	702	-	ENSP00000413383	201 (aa)	-	Q5T0R4
ENST00000414893	CAP1-208	528	-	ENSP00000398877	145 (aa)	-	Q5T0S3
ENST00000446031	CAP1-215	273	-	ENSP00000389974	58 (aa)	-	Q5T0R8
ENST00000372802	CAP1-205	2964	XM_011540515	ENSP00000361888	474 (aa)	XP_011538817	Q01518
ENST00000420216	CAP1-210	668	-	ENSP00000410586	179 (aa)	-	Q5T0R5
ENST00000461993	CAP1-217	856	-	-	- (aa)	-	-
ENST00000372805	CAP1-206	2217	-	ENSP00000361891	475 (aa)	-	Q01518
ENST00000372797	CAP1-203	3105	XM_011540510	ENSP00000361883	475 (aa)	XP_011538812	Q01518
ENST00000449311	CAP1-216	681	-	ENSP00000398475	174 (aa)	-	Q5T0R7
ENST00000427843	CAP1-213	739	-	ENSP00000413656	215 (aa)	-	Q5T0R1
ENST00000372792	CAP1-202	1496	-	ENSP00000361878	475 (aa)	-	Q01518
ENST00000340450	CAP1-201	2592	-	ENSP00000344832	474 (aa)	-	Q01518
ENST00000414281	CAP1-207	772	-	ENSP00000408561	208 (aa)	-	Q5T0R2
ENST00000421589	CAP1-211	824	-	ENSP00000403198	203 (aa)	-	Q5T0R3
ENST00000372798	CAP1-204	1563	-	ENSP00000361884	474 (aa)	-	Q01518

Gene Model

Click here to download ENSG00000131236's gene model file

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000131236	rs3131667	1	40063357	?	White blood cell count	30595370			EFO_0004308

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000131236's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000131236	CAP1	91	47.477	FBgn0261458	capt	99	48.624	Drosophila_melanogaster
ENSG00000131236	CAP1	99	33.398	YNL138W	SRV2	97	34.556	Saccharomyces_cerevisiae

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000902	cell morphogenesis	21873635.	IBA	Process
GO:0001667	ameboidal-type cell migration	-	IEA	Process
GO:0003779	actin binding	21873635.	IBA	Function
GO:0005576	extracellular region	-	TAS	Component
GO:0005886	plasma membrane	-	IEA	Component
GO:0005925	focal adhesion	21423176.	HDA	Component
GO:0006898	receptor-mediated endocytosis	-	IEA	Process
GO:0007163	establishment or maintenance of cell polarity	21873635.	IBA	Process
GO:0007165	signal transduction	1406678.	TAS	Process
GO:0007190	activation of adenylate cyclase activity	7962207.	TAS	Process
GO:0008154	actin polymerization or depolymerization	21873635.	IBA	Process
GO:0008179	adenylate cyclase binding	21873635.	IBA	Function
GO:0030864	cortical actin cytoskeleton	21873635.	IBA	Component
GO:0035578	azurophil granule lumen	-	TAS	Component
GO:0043312	neutrophil degranulation	-	TAS	Process
GO:0070062	extracellular exosome	19056867.19199708.20458337.23533145.	HDA	Component

EuRBPDB

Note: to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Expression

Transcripts

Gene Model

GWAS

PPI

Orthologs

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.