EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
21918680	Re-expression of AKAP12 inhibits progression and metastasis potential of colorectal carcinoma in vivo and in vitro.	PLoS One	2011	Liu W	doi: 10.1371/journal.pone.0024015
22584896	The angiogenesis suppressor gene AKAP12 is under the epigenetic control of HDAC7 in endothelial cells.	Angiogenesis	2012 Dec	Turtoi A	doi: 10.1007/s10456-012-9279-8
21461577	Inhibition of endothelial cell migration through the downregulation of MMP-9 by A-kinase anchoring protein 12.	Mol Med Rep	2011 Jan-Feb	Lee SW	doi: 10.3892/mmr.2010.389
18554502	A-kinase anchoring protein 12 regulates the completion of cytokinesis.	Biochem Biophys Res Commun	2008 Aug 15	Choi MC	doi: 10.1016/j.bbrc.2008.05.184
17442483	AKAP12 induces apoptotic cell death in human fibrosarcoma cells by regulating CDKI-cyclin D1 and caspase-3 activity.	Cancer Lett	2007 Aug 28	Yoon DK	-
20979053	Down-regulation of tumor suppressor A kinase anchor protein 12 in human hepatocarcinogenesis by epigenetic mechanisms.	Hepatology	2010 Dec	Goeppert B	doi: 10.1002/hep.23939
28698137	SSeCKS/AKAP12 induces repulsion between human prostate cancer and microvessel endothelial cells through the activation of Semaphorin 3F.	Biochem Biophys Res Commun	2017 Sep 2	Xie W	doi: 10.1016/j.bbrc.2017.07.043
20364105	Quantitative assessment of AKAP12 promoter methylation in colorectal cancer using methylation-sensitive high resolution melting: Correlation with Duke's stage.	Cancer Biol Ther	2010 Jun 1	Liu W	-
25748058	Elevated AKAP12 in paclitaxel-resistant serous ovarian cancer cells is prognostic and predictive of poor survival in patients.	J Proteome Res	2015 Apr 3	Bateman NW	doi: 10.1021/pr5012894
15258566	AKAP12/Gravin is inactivated by epigenetic mechanism in human gastric carcinoma and shows growth suppressor activity.	Oncogene	2004 Sep 16	Choi MC	-
24065476	AKAP12/Gravin gene expression in colorectal cancer: clinical importance and review of the literature.	J BUON	2013 Jul-Sep	Yildirim M	-
21115911	Methylation of AKAP12{alpha} promoter in lung cancer.	Anticancer Res	2010 Nov	Jo UH	-
26645718	Evaluation of potential regulatory function of breast cancer risk locus at 6q25.1.	Carcinogenesis	2016 Feb	Sun Y	doi: 10.1093/carcin/bgv170
21310466	Quantitative assessment of AKAP12 promoter methylation in human prostate cancer using methylation-sensitive high-resolution melting: correlation with Gleason score.	Urology	2011 Apr	Liu W	doi: 10.1016/j.urology.2010.12.010
29484387	Upregulation of AKAP12 with HDAC3 depletion suppresses the progression and migration of colorectal cancer.	Int J Oncol	2018 Apr	He P	doi: 10.3892/ijo.2018.4284
30385176	A-kinase anchor protein 12 (AKAP12) inhibits cell migration in breast cancer.	Exp Mol Pathol	2018 Dec	Soh RYZ	doi: 10.1016/j.yexmp.2018.10.010

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
ACC	chr6	151350915	Missense_Mutation	novel	D842Y	0.41
ACC	chr6	151352267	Missense_Mutation	rs749174370	I1292M	0.45
ACC	chr6	151325881	Intron	novel		0.15
ACC	chr6	151351141	Missense_Mutation	novel	S917L	0.2
ACC	chr6	151351230	Frame_Shift_Del	NA	*T949Rfs23**	0.9
BLCA	chr6	151353596	Silent	novel	Q1735Q	0.11
BLCA	chr6	151348746	Missense_Mutation	novel	D119H	0.26
BLCA	chr6	151352409	Missense_Mutation	novel	Q1340E	0.07
BLCA	chr6	151350499	Missense_Mutation	NA	G703E	0.1
BLCA	chr6	151353063	Missense_Mutation	rs192628192	V1558I	0.24
BLCA	chr6	151350972	Missense_Mutation	novel	E861Q	0.14
BLCA	chr6	151350036	Missense_Mutation	novel	Q549E	0.52
BLCA	chr6	151348830	Missense_Mutation	rs138659689	E147K	0.38
BLCA	chr6	151349730	Missense_Mutation	novel	L447V	0.42
BLCA	chr6	151351091	Silent	rs772778007	T900T	0.5
BLCA	chr6	151352840	Silent	rs555709389	S1483S	0.5
BLCA	chr6	151350569	Silent	rs754437547	D726D	0.27
BLCA	chr6	151349388	Missense_Mutation	novel	E333Q	0.34
BLCA	chr6	151353214	Frame_Shift_Ins	novel	*E1608Dfs24**	0.08
BLCA	chr6	151353215	Silent	novel	E1608E	0.03
BLCA	chr6	151350054	Missense_Mutation	novel	P555S	0.51
BLCA	chr6	151352163	Silent	novel	L1258L	0.23
BLCA	chr6	151305744	Splice_Region	novel		0.42
BLCA	chr6	151352659	Missense_Mutation	novel	A1423E	0.46
BRCA	chr6	151349221	Missense_Mutation	novel	P277H	0.19
BRCA	chr6	151350521	Missense_Mutation	NA	D710E	0.11
BRCA	chr6	151351859	Silent	NA	Q1156Q	0.22
BRCA	chr6	151350204	Missense_Mutation	NA	E605K	0.19
BRCA	chr6	151353726	Missense_Mutation	rs755923718	L1779F	0.55
BRCA	chr6	151350534	Missense_Mutation	novel	D715N	0.11
BRCA	chr6	151350304	Missense_Mutation	novel	V638D	0.07
BRCA	chr6	151352292	Missense_Mutation	novel	E1301Q	0.38
BRCA	chr6	151353087	Missense_Mutation	rs766494880	E1566K	0.19
BRCA	chr6	151351545	Missense_Mutation	novel	E1052Q	0.18
BRCA	chr6	151349125	Missense_Mutation	NA	R245H	0.16
BRCA	chr6	151352109	Missense_Mutation	novel	E1240K	0.22
BRCA	chr6	151352715	Frame_Shift_Del	NA	*E1442Kfs10**	0.26
BRCA	chr6	151349190	Missense_Mutation	NA	E267Q	0.12
CESC	chr6	151353114	Missense_Mutation	novel	E1575Q	0.2
CESC	chr6	151353152	Missense_Mutation	novel	S1587R	0.23
CESC	chr6	151352659	Missense_Mutation	NA	A1423V	0.12
CESC	chr6	151352141	Silent	NA	V1250V	0.79
CESC	chr6	151350186	Missense_Mutation	novel	D599N	0.32
CESC	chr6	151350759	Missense_Mutation	novel	E790Q	0.35
CESC	chr6	151352034	Missense_Mutation	NA	P1215S	0.38
CESC	chr6	151348887	Nonsense_Mutation	novel	Q166*	0.45
CESC	chr6	151352167	Missense_Mutation	NA	S1259L	0.24
CESC	chr6	151350918	Missense_Mutation	rs753654154	V843I	0.51
COAD	chr6	151349243	Silent	rs145689161	P284P	0.45
COAD	chr6	151349652	Missense_Mutation	novel	V421I	0.34
COAD	chr6	151350961	Missense_Mutation	NA	R857M	0.37
COAD	chr6	151351662	Missense_Mutation	NA	D1091N	0.31
COAD	chr6	151351476	Missense_Mutation	rs769872883	V1029I	0.46
COAD	chr6	151351865	Frame_Shift_Del	NA	*P1160Lfs18**	0.22
COAD	chr6	151349109	Missense_Mutation	rs552053449	E240K	0.5
COAD	chr6	151348887	Missense_Mutation	novel	Q166K	0.37
COAD	chr6	151348937	Silent	novel	K182K	0.5
COAD	chr6	151349446	Missense_Mutation	novel	A352V	0.12
COAD	chr6	151350458	Missense_Mutation	novel	K689N	0.05
COAD	chr6	151351180	Missense_Mutation	novel	A930E	0.13
COAD	chr6	151349169	Nonsense_Mutation	NA	Q260*	0.08
COAD	chr6	151348920	Missense_Mutation	NA	K177E	0.21
COAD	chr6	151349217	Nonsense_Mutation	novel	E276*	0.25
COAD	chr6	151350463	Missense_Mutation	rs752036291	R691I	0.31
COAD	chr6	151349253	Missense_Mutation	rs764470310	V288M	0.7
COAD	chr6	151352694	Missense_Mutation	novel	A1435S	0.19
COAD	chr6	151350080	Silent	rs750541234	G563G	0.33
COAD	chr6	151351179	Missense_Mutation	rs375774812	A930T	0.4
COAD	chr6	151351642	Nonsense_Mutation	NA	S1084*	0.35
COAD	chr6	151351287	Missense_Mutation	rs140014031	V966I	0.2
COAD	chr6	151349313	Missense_Mutation	rs759658755	R308C	0.33
COAD	chr6	151349246	Silent	novel	T285T	0.54
COAD	chr6	151352767	Frame_Shift_Del	NA	*N1461Mfs26**	0.52
COAD	chr6	151348840	Missense_Mutation	novel	P150H	0.37
COAD	chr6	151350544	Missense_Mutation	novel	G718E	0.36
COAD	chr6	151351865	Frame_Shift_Del	NA	*P1160Lfs18**	0.38
COAD	chr6	151349445	Missense_Mutation	rs769926929	A352T	0.32
COAD	chr6	151351708	Missense_Mutation	novel	F1106C	0.11
COAD	chr6	151351624	Missense_Mutation	NA	E1078G	0.27
COAD	chr6	151352600	Frame_Shift_Del	novel	*E1404Rfs18**	0.17
COAD	chr6	151353425	Missense_Mutation	NA	D1678E	0.4
COAD	chr6	151348788	Missense_Mutation	rs200778076	D133N	0.1
COAD	chr6	151350096	Missense_Mutation	novel	S569P	0.16
COAD	chr6	151350061	Missense_Mutation	NA	S557N	0.12
COAD	chr6	151351639	Missense_Mutation	rs141178416	A1083V	0.36
COAD	chr6	151351934	Silent	rs573717108	D1181D	0.35
COAD	chr6	151350374	Silent	NA	V661V	0.1
COAD	chr6	151349915	Missense_Mutation	novel	R508S	0.19
COAD	chr6	151352123	Silent	NA	E1244E	0.24
COAD	chr6	151349139	Missense_Mutation	rs149211517	A250T	0.39
COAD	chr6	151350591	Nonsense_Mutation	NA	E734*	0.28
COAD	chr6	151352756	Silent	NA	E1455E	0.16
COAD	chr6	151353099	Missense_Mutation	NA	E1570K	0.3
COAD	chr6	151353476	Silent	rs569287283	P1695P	0.26
COAD	chr6	151352058	Missense_Mutation	novel	A1223S	0.26
COAD	chr6	151351079	Silent	novel	V896V	0.26
COAD	chr6	151351865	Frame_Shift_Del	NA	*P1160Lfs18**	0.17
COAD	chr6	151350885	Missense_Mutation	NA	G832R	0.4
COAD	chr6	151350295	Missense_Mutation	novel	L635P	0.29
COAD	chr6	151352722	Missense_Mutation	NA	L1444W	0.86
ESCA	chr6	151352403	Missense_Mutation	novel	V1338I	0.25
ESCA	chr6	151356010	3'UTR	novel		0.39
ESCA	chr6	151352980	In_Frame_Ins	novel	I1530delinsMD	0.46
ESCA	chr6	151356167	3'UTR	novel		0.55
ESCA	chr6	151305809	Silent	novel	S75S	0.19
GBM	chr6	151353180	Frame_Shift_Del	novel	*E1597Kfs38**	0.12
GBM	chr6	151325809	Intron	novel		0.36
GBM	chr6	151350697	Missense_Mutation	novel	R769I	0.27
GBM	chr6	151351365	Missense_Mutation	rs199808949	E992K	0.28
GBM	chr6	151351517	Silent	novel	V1042V	0.2
HNSC	chr6	151350402	Missense_Mutation	rs771936289	R671C	0.11
HNSC	chr6	151352342	Missense_Mutation	novel	D1317E	0.21
HNSC	chr6	151349369	Missense_Mutation	novel	K326N	0.18
HNSC	chr6	151350600	Missense_Mutation	rs781225876	P737T	0.28
HNSC	chr6	151348751	Silent	rs777029366	S120S	0.31
HNSC	chr6	151325823	Intron	novel		0.33
HNSC	chr6	151352590	Missense_Mutation	novel	L1400P	0.22
HNSC	chr6	151350527	Silent	novel	Q712Q	0.45
HNSC	chr6	151350657	Missense_Mutation	rs758119251	V756I	0.07
HNSC	chr6	151351108	Missense_Mutation	rs776331528	I906T	0.27
HNSC	chr6	151350271	Missense_Mutation	rs761711528	S627L	0.17
HNSC	chr6	151349241	Missense_Mutation	novel	P284T	0.29
HNSC	chr6	151352142	Missense_Mutation	novel	S1251T	0.26
HNSC	chr6	151353036	Missense_Mutation	novel	L1549I	0.59
HNSC	chr6	151351980	Missense_Mutation	novel	E1197K	0.16
HNSC	chr6	151350559	Missense_Mutation	rs201814292	T723M	0.09
HNSC	chr6	151351097	Silent	novel	A902A	0.27
KICH	chr6	151350347	Silent	novel	E652E	0.29
KIRC	chr6	151349205	Frame_Shift_Del	novel	*K272Nfs17**	0.22
KIRC	chr6	151349324	Silent	NA	T311T	0.37
KIRC	chr6	151350255	Missense_Mutation	NA	R622S	0.2
KIRP	chr6	151350524	Frame_Shift_Del	novel	*Q712Rfs54**	0.36
KIRP	chr6	151352900	Missense_Mutation	novel	E1503D	0.3
LAML	chr6	151353714	Missense_Mutation	rs761472870	A1775T	0.14
LAML	chr6	151352607	Missense_Mutation	NA	V1406I	0.37
LAML	chr6	151348838	Silent	novel	I149I	0.11
LGG	chr6	151351815	Missense_Mutation	rs200662204	E1142K	0.17
LGG	chr6	151353632	Silent	novel	Q1747Q	0.08
LIHC	chr6	151349876	Silent	rs370245999	G495G	0.26
LIHC	chr6	151349850	Nonsense_Mutation	NA	K487*	0.6
LUAD	chr6	151352702	Silent	novel	I1437I	0.49
LUAD	chr6	151350886	Missense_Mutation	NA	G832A	0.2
LUAD	chr6	151325811	Intron	novel		0.2
LUAD	chr6	151352863	Missense_Mutation	NA	T1491I	0.12
LUAD	chr6	151353275	Silent	NA	S1628S	0.15
LUAD	chr6	151350981	Missense_Mutation	NA	Q864K	0.16
LUAD	chr6	151305752	Silent	rs763642797	L56L	0.24
LUAD	chr6	151352075	Silent	NA	V1228V	0.23
LUAD	chr6	151349125	Missense_Mutation	NA	R245H	0.07
LUAD	chr6	151349531	Silent	NA	P380P	0.08
LUAD	chr6	151351782	Missense_Mutation	rs142987485	E1131Q	0.24
LUAD	chr6	151350124	Missense_Mutation	rs150161531	C578Y	0.43
LUAD	chr6	151350397	Missense_Mutation	novel	P669Q	0.3
LUAD	chr6	151348778	Silent	rs749900365	A129A	0.09
LUAD	chr6	151350274	Missense_Mutation	novel	E628G	0.09
LUAD	chr6	151352972	Missense_Mutation	novel	S1527R	0.11
LUAD	chr6	151352445	Missense_Mutation	novel	H1352N	0.28
LUAD	chr6	151349027	Silent	NA	A212A	0.12
LUAD	chr6	151353134	Silent	rs374182415	H1581H	0.18
LUAD	chr6	151351037	Silent	NA	K882K	0.18
LUAD	chr6	151350582	Missense_Mutation	novel	G731S	0.14
LUAD	chr6	151350025	Missense_Mutation	novel	G545E	0.07
LUSC	chr6	151351286	Silent	rs774286589	V965V	0.29
LUSC	chr6	151352719	Missense_Mutation	novel	T1443K	0.27
LUSC	chr6	151305771	Missense_Mutation	novel	S63T	0.16
LUSC	chr6	151350389	Silent	rs747947110	P666P	0.14
LUSC	chr6	151351020	Missense_Mutation	NA	A877T	0.13
LUSC	chr6	151305822	Missense_Mutation	novel	D80Y	0.25
LUSC	chr6	151349333	Missense_Mutation	novel	R314S	0.17
LUSC	chr6	151349820	Missense_Mutation	novel	T477S	0.23
LUSC	chr6	151305874	Missense_Mutation	novel	Q97L	0.21
LUSC	chr6	151348750	Missense_Mutation	NA	S120F	0.32
LUSC	chr6	151348751	Silent	rs777029366	S120S	0.34
LUSC	chr6	151349031	Missense_Mutation	rs757336172	D214N	0.49
MESO	chr6	151349806	Missense_Mutation	novel	S472F	0.3
OV	chr6	151352181	Missense_Mutation	novel	T1264S	0.25
OV	chr6	151352153	Silent	NA	T1254T	0.49
OV	chr6	151348892	Silent	novel	A167A	0.29
OV	chr6	151351670	Silent	novel	V1093V	0.15
OV	chr6	151348736	Silent	NA	V115V	0.34
OV	chr6	151351853	Missense_Mutation	novel	M1154I	0.13
OV	chr6	151349695	Missense_Mutation	novel	V435A	0.08
OV	chr6	151353407	Silent	NA	T1672T	0.36
OV	chr6	151350274	Missense_Mutation	novel	E628G	0.09
PAAD	chr6	151350310	Missense_Mutation	novel	S640N	0.05
PAAD	chr6	151350882	Missense_Mutation	novel	A831T	0.16
PAAD	chr6	151351592	Silent	novel	Q1067Q	0.2
PAAD	chr6	151348818	Missense_Mutation	novel	P143T	0.03
PCPG	chr6	151350929	Silent	novel	V846V	0.41
PRAD	chr6	151349433	Missense_Mutation	rs200318359	E348K	0.1
PRAD	chr6	151350657	Missense_Mutation	rs758119251	V756I	0.26
PRAD	chr6	151351992	Missense_Mutation	NA	A1201T	0.06
PRAD	chr6	151350569	Silent	rs754437547	D726D	0.17
PRAD	chr6	151350403	Missense_Mutation	rs190920353	R671H	0.18
READ	chr6	151353712	Missense_Mutation	NA	S1774F	0.61
READ	chr6	151351262	Missense_Mutation	rs377313534	N957K	0.28
READ	chr6	151350214	Missense_Mutation	novel	T608N	0.33
READ	chr6	151350195	Frame_Shift_Del	novel	*R604Efs14**	0.3
READ	chr6	151348743	Missense_Mutation	novel	R118G	0.12
READ	chr6	151351339	Missense_Mutation	NA	G983V	0.56
READ	chr6	151351533	Missense_Mutation	novel	E1048K	0.4
READ	chr6	151352235	Missense_Mutation	rs368517285	E1282K	0.47
READ	chr6	151352387	Silent	rs142473808	P1332P	0.35
READ	chr6	151348931	Silent	novel	G180G	0.1
READ	chr6	151349160	Missense_Mutation	rs775211883	E257K	0.48
READ	chr6	151352617	Missense_Mutation	NA	K1409T	0.43
SARC	chr6	151350804	Missense_Mutation	novel	V805I	0.21
SARC	chr6	151352292	Missense_Mutation	novel	E1301K	0.04
SARC	chr6	151351692	Missense_Mutation	novel	A1101S	0.37
SARC	chr6	151352767	Frame_Shift_Del	NA	*N1461Mfs26**	0.26
SKCM	chr6	151351568	Silent	rs201622303	T1059T	0.36
SKCM	chr6	151351742	Silent	NA	P1117P	0.36
SKCM	chr6	151350055	Missense_Mutation	rs145059917	P555L	0.4
SKCM	chr6	151350640	Missense_Mutation	novel	P750L	0.28
SKCM	chr6	151353229	Missense_Mutation	novel	S1613L	0.07
SKCM	chr6	151349813	Silent	NA	E474E	0.27
SKCM	chr6	151350815	Silent	NA	K808K	0.37
SKCM	chr6	151351245	Missense_Mutation	NA	E952K	0.27
SKCM	chr6	151351040	Silent	NA	E883E	0.65
SKCM	chr6	151350217	Missense_Mutation	NA	P609L	0.42
SKCM	chr6	151352896	Missense_Mutation	novel	G1502E	0.06
SKCM	chr6	151351631	Silent	novel	Q1080Q	0.31
SKCM	chr6	151351901	Silent	novel	E1170E	0.17
SKCM	chr6	151350516	Missense_Mutation	NA	G709R	0.36
SKCM	chr6	151352318	Frame_Shift_Del	novel	*E1310Rfs3**	0.21
SKCM	chr6	151352525	Silent	NA	V1378V	0.15
SKCM	chr6	151351442	Silent	novel	E1017E	0.4
SKCM	chr6	151352263	Missense_Mutation	novel	G1291V	0.21
STAD	chr6	151350255	Missense_Mutation	rs143476871	R622C	0.11
STAD	chr6	151353562	Missense_Mutation	NA	T1724S	0.17
STAD	chr6	151348829	Silent	rs561437815	I146I	0.23
STAD	chr6	151352823	Missense_Mutation	rs775450726	D1478N	0.27
STAD	chr6	151349187	Frame_Shift_Del	novel	*K266Rfs12**	0.4
STAD	chr6	151349489	Silent	rs752192182	H366H	0.3
STAD	chr6	151353664	Missense_Mutation	novel	A1758V	0.41
STAD	chr6	151351230	Frame_Shift_Del	NA	*T949Rfs23**	0.3
STAD	chr6	151350831	Nonsense_Mutation	NA	R814*	0.1
STAD	chr6	151353197	Silent	NA	Q1602Q	0.31
STAD	chr6	151351237	Missense_Mutation	rs766910226	T949M	0.3
STAD	chr6	151351864	Frame_Shift_Ins	novel	D1161*	0.38
STAD	chr6	151351397	Missense_Mutation	NA	M1002I	0.64
STAD	chr6	151351090	Missense_Mutation	rs771644564	T900M	0.5
STAD	chr6	151351230	Frame_Shift_Del	NA	*T949Rfs23**	0.17
STAD	chr6	151350127	Missense_Mutation	novel	L579P	0.25
STAD	chr6	151353207	Missense_Mutation	novel	Q1606E	0.36
STAD	chr6	151349314	Missense_Mutation	rs141729078	R308H	0.14
STAD	chr6	151353145	Frame_Shift_Ins	novel	*D1586Vfs50**	0.08
STAD	chr6	151351731	Missense_Mutation	NA	Q1114K	0.33
STAD	chr6	151350218	Silent	NA	P609P	0.28
STAD	chr6	151353148	Missense_Mutation	NA	D1586G	0.32
STAD	chr6	151349109	Missense_Mutation	rs552053449	E240K	0.21
STAD	chr6	151352312	Silent	novel	E1307E	0.22
STAD	chr6	151351047	Missense_Mutation	rs149275104	E886K	0.24
STAD	chr6	151349877	Missense_Mutation	rs374740675	V496I	0.2
STAD	chr6	151351229	Silent	NA	E946E	0.09
STAD	chr6	151351475	Silent	NA	G1028G	0.13
STAD	chr6	151350312	Missense_Mutation	rs753094802	A641T	0.21
STAD	chr6	151351229	Frame_Shift_Ins	rs767490652	*T949Hfs4**	0.19
STAD	chr6	151353076	Missense_Mutation	NA	V1562A	0.18
STAD	chr6	151352767	Frame_Shift_Del	NA	*N1461Mfs26**	0.2
STAD	chr6	151350080	Silent	rs750541234	G563G	0.29
THCA	chr6	151350387	Missense_Mutation	NA	P666T	0.31
THCA	chr6	151349224	Missense_Mutation	novel	S278N	0.07
UCEC	chr6	151351906	Missense_Mutation	novel	D1172G	0.22
UCEC	chr6	151350393	Nonsense_Mutation	NA	E668*	0.34
UCEC	chr6	151350839	Missense_Mutation	NA	K816N	0.36
UCEC	chr6	151353718	Missense_Mutation	NA	K1776T	0.36
UCEC	chr6	151348821	Missense_Mutation	rs146335151	E144K	0.09
UCEC	chr6	151349944	Missense_Mutation	NA	K518T	0.29
UCEC	chr6	151353045	Missense_Mutation	novel	N1552H	0.38
UCEC	chr6	151351423	Missense_Mutation	NA	D1011G	0.3
UCEC	chr6	151353284	Silent	novel	S1631S	0.1
UCEC	chr6	151351918	Missense_Mutation	novel	P1176L	0.17
UCEC	chr6	151352806	Missense_Mutation	novel	A1472D	0.47
UCEC	chr6	151349898	Silent	novel	L503L	0.2
UCEC	chr6	151305880	Missense_Mutation	novel	E99G	0.44
UCEC	chr6	151350925	Missense_Mutation	novel	A845V	0.53
UCEC	chr6	151349199	Nonsense_Mutation	NA	E270*	0.23
UCEC	chr6	151349566	Missense_Mutation	NA	S392Y	0.33
UCEC	chr6	151348875	Missense_Mutation	novel	P162S	0.53
UCEC	chr6	151350311	Silent	rs186475520	S640S	0.36
UCEC	chr6	151351120	Missense_Mutation	novel	S910Y	0.44
UCEC	chr6	151351364	Silent	rs370701327	T991T	0.34
UCEC	chr6	151353267	Missense_Mutation	novel	A1626S	0.39
UCEC	chr6	151305863	Silent	novel	A93A	0.2
UCEC	chr6	151350638	Silent	rs762123639	S749S	0.41
UCEC	chr6	151352839	Missense_Mutation	novel	S1483L	0.29
UCEC	chr6	151349134	Missense_Mutation	novel	S248I	0.39
UCEC	chr6	151349299	Missense_Mutation	novel	G303D	0.31
UCEC	chr6	151350988	Frame_Shift_Del	novel	*S868Afs24**	0.42
UCEC	chr6	151352285	Silent	novel	K1298K	0.57
UCEC	chr6	151352886	Missense_Mutation	novel	D1499N	0.52
UCEC	chr6	151353412	Missense_Mutation	novel	S1674Y	0.19
UCEC	chr6	151353706	Missense_Mutation	novel	R1772I	0.13
UCEC	chr6	151351656	Nonsense_Mutation	novel	E1089*	0.2
UCEC	chr6	151352659	Missense_Mutation	NA	A1423V	0.24
UCEC	chr6	151349628	Nonsense_Mutation	NA	E413*	0.34
UCEC	chr6	151351277	Silent	rs573213287	G962G	0.19
UCEC	chr6	151352046	Nonsense_Mutation	NA	E1219*	0.36
UCEC	chr6	151348751	Silent	rs777029366	S120S	0.3
UCEC	chr6	151350265	Missense_Mutation	rs774124521	R625Q	0.26
UCEC	chr6	151351959	Missense_Mutation	rs771722071	E1190K	0.1
UCEC	chr6	151352222	Silent	rs756720446	D1277D	0.13
UCEC	chr6	151352322	Nonsense_Mutation	NA	E1311*	0.25
UCEC	chr6	151352719	Missense_Mutation	rs760044084	T1443M	0.23
UCEC	chr6	151353041	Silent	NA	V1550V	0.08
UCEC	chr6	151353158	Silent	rs149415779	D1589D	0.29
UCEC	chr6	151355989	3'UTR	novel		0.41
UCEC	chr6	151350926	Silent	rs752752017	A845A	0.8
UCEC	chr6	151351992	Missense_Mutation	NA	A1201T	0.07
UCEC	chr6	151350080	Silent	rs750541234	G563G	0.17
UCEC	chr6	151348974	Missense_Mutation	novel	T195A	0.52
UCEC	chr6	151351800	Missense_Mutation	novel	T1137A	0.45
UCEC	chr6	151350052	Missense_Mutation	novel	S554Y	0.5
UCEC	chr6	151353326	Missense_Mutation	NA	E1645D	0.18
UCEC	chr6	151351237	Missense_Mutation	rs766910226	T949M	0.29
UCEC	chr6	151350567	Missense_Mutation	novel	D726N	0.38
UCEC	chr6	151350474	Missense_Mutation	novel	G695W	0.55
UCEC	chr6	151351643	Silent	rs780939900	S1084S	0.35
UCEC	chr6	151352324	Missense_Mutation	NA	E1311D	0.43
UCEC	chr6	151352471	Silent	rs374901951	H1360H	0.42
UCEC	chr6	151348896	Missense_Mutation	novel	D169Y	0.28
UCEC	chr6	151352936	Silent	novel	V1515V	0.4
UCEC	chr6	151350218	Silent	NA	P609P	0.37
UCEC	chr6	151351705	Missense_Mutation	novel	P1105H	0.45
UCEC	chr6	151351926	Missense_Mutation	rs747371302	D1179N	0.73
UCEC	chr6	151351149	Nonsense_Mutation	novel	E920*	0.15
UCEC	chr6	151351340	Silent	NA	G983G	0.35
UCEC	chr6	151352823	Missense_Mutation	rs775450726	D1478N	0.31
UCEC	chr6	151352766	Frame_Shift_Ins	novel	*N1461Kfs2**	0.48
UCEC	chr6	151348830	Missense_Mutation	rs138659689	E147K	0.34
UCEC	chr6	151352795	Frame_Shift_Ins	novel	*G1469Wfs46**	0.6
UCEC	chr6	151356271	3'UTR	novel		0.44
UCEC	chr6	151353404	Silent	novel	G1671G	0.5
UCEC	chr6	151351809	Frame_Shift_Ins	NA	*A1141Sfs21**	0.38
UCEC	chr6	151349412	Missense_Mutation	rs561110627	G341R	0.36
UCEC	chr6	151348830	Missense_Mutation	rs138659689	E147K	0.29
UCEC	chr6	151351815	Missense_Mutation	rs200662204	E1142K	0.39
UCEC	chr6	151352220	Missense_Mutation	novel	D1277N	0.12
UCEC	chr6	151356029	3'UTR	novel		0.19
UCEC	chr6	151351211	Silent	novel	E940E	0.41
UCEC	chr6	151350311	Silent	rs186475520	S640S	0.39
UCEC	chr6	151350881	Silent	rs202238535	D830D	0.39
UCEC	chr6	151353618	Missense_Mutation	novel	E1743K	0.53
UCEC	chr6	151350623	Silent	rs576942154	P744P	0.37
UCEC	chr6	151356341	3'UTR	novel		0.67
UCEC	chr6	151351877	Silent	NA	S1162S	0.47
UCEC	chr6	151351230	Frame_Shift_Del	NA	*T949Rfs23**	0.51
UCEC	chr6	151305825	Missense_Mutation	NA	L81I	0.21
UCEC	chr6	151350012	Missense_Mutation	NA	D541Y	0.23
UCEC	chr6	151348835	Silent	novel	Q148Q	0.27
UCEC	chr6	151351893	Missense_Mutation	novel	D1168Y	0.38
UCEC	chr6	151352756	Missense_Mutation	novel	E1455D	0.33
UCEC	chr6	151325846	Intron	novel		0.17
UCEC	chr6	151305785	Silent	rs755282610	G67G	0.35
UCEC	chr6	151349824	Missense_Mutation	novel	Q478R	0.46
UCEC	chr6	151352960	Silent	novel	E1523E	0.37
UCEC	chr6	151356184	3'UTR	novel		0.09
UCEC	chr6	151350014	Silent	rs367749583	D541D	0.36
UCEC	chr6	151352298	Missense_Mutation	NA	A1303T	0.05
UCEC	chr6	151350185	Silent	rs779577166	S598S	0.45
UCEC	chr6	151353278	Silent	NA	D1629D	0.44
UCEC	chr6	151352659	Missense_Mutation	NA	A1423V	0.35
UCEC	chr6	151305752	Silent	rs763642797	L56L	0.13
UCEC	chr6	151348884	Missense_Mutation	NA	S165A	0.3
UCEC	chr6	151350696	Silent	NA	R769R	0.46
UCEC	chr6	151352408	Silent	novel	V1339V	0.31
UCEC	chr6	151349975	Silent	novel	L528L	0.34
UCEC	chr6	151352839	Missense_Mutation	novel	S1483L	0.37
UCEC	chr6	151353368	Silent	rs200457723	V1659V	0.04
UCEC	chr6	151325757	Intron	novel		0.64
UCEC	chr6	151351080	Missense_Mutation	rs746212006	A897T	0.14
UCEC	chr6	151351698	Missense_Mutation	novel	T1103A	0.39
UCEC	chr6	151351835	Silent	novel	K1148K	0.27
UCEC	chr6	151348964	Missense_Mutation	novel	E191D	0.06
UCEC	chr6	151351364	Silent	rs370701327	T991T	0.1
UCEC	chr6	151352812	Missense_Mutation	novel	P1474H	0.64
UCEC	chr6	151351941	Missense_Mutation	novel	G1184C	0.56
UCEC	chr6	151350569	Silent	rs754437547	D726D	0.36
UCEC	chr6	151350887	Silent	novel	G832G	0.25
UCEC	chr6	151352978	Silent	novel	A1529A	0.37
UCEC	chr6	151353237	Nonsense_Mutation	novel	E1616*	0.32
UCS	chr6	151349967	Missense_Mutation	novel	K526Q	0.41
UCS	chr6	151350357	Nonsense_Mutation	novel	E656*	0.28

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
BLCA	DEL	0.3603	0.00027473
KIRC	DEL	0.2443	7.439e-11
KIRP	DEL	0.1042	0.054498
LGG	DEL	0.1442	0.0054594
MESO	DEL	0.4138	0.05642
PAAD	DEL	0.375	0.11274
SKCM	DEL	0.5559	1.5442e-06
THYM	DEL	0.1463	0.10691
UVM	DEL	0.275	0.0054289

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.00016	Kaplan-Meier Survival Analysis
STAD	0.00091	Kaplan-Meier Survival Analysis
MESO	0.0069	Kaplan-Meier Survival Analysis
ACC	0.00014	Kaplan-Meier Survival Analysis
HNSC	0.045	Kaplan-Meier Survival Analysis
SKCM	0.0029	Kaplan-Meier Survival Analysis
PRAD	0.043	Kaplan-Meier Survival Analysis
LUSC	0.0066	Kaplan-Meier Survival Analysis
BLCA	0.0065	Kaplan-Meier Survival Analysis
LAML	0.00032	Kaplan-Meier Survival Analysis
UCEC	0.001	Kaplan-Meier Survival Analysis
LGG	0.00031	Kaplan-Meier Survival Analysis
THCA	0.028	Kaplan-Meier Survival Analysis
LUAD	0.0001	Kaplan-Meier Survival Analysis
OV	0.007	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Expression

Transcripts

Gene Model

Phenotype

GWAS

PPI

Gene Ontology

Description

Ensembl ID: ENSG00000131016 (Gene tree)
Gene ID: 9590
Gene Symbol: AKAP12
Alias: AKAP250|SSeCKS
Full Name: A-kinase anchoring protein 12
Gene Type: protein_coding
Specie: Homo_sapiens
Strand: Plus strand
Length: 118,561 bases
Position: chr6:151,239,999-151,358,559
Accession: 370
Summary: The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein is expressed in endothelial cells, cultured fibroblasts, and osteosarcoma cells. It associates with protein kinases A and C and phosphatase, and serves as a scaffold protein in signal transduction. This protein and RII PKA colocalize at the cell periphery. This protein is a cell growth-related protein. Antibodies to this protein can be produced by patients with myasthenia gravis. Alternative splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000354675	AKAP12-202	6287	-	ENSP00000346702	1684 (aa)	-	Q02952
ENST00000402676	AKAP12-204	8432	XM_017011517	ENSP00000384537	1782 (aa)	XP_016867006	Q02952
ENST00000253332	AKAP12-201	6597	-	ENSP00000253332	1782 (aa)	-	Q02952
ENST00000490177	AKAP12-205	561	-	-	- (aa)	-	-
ENST00000359755	AKAP12-203	6190	XM_005267235	ENSP00000352794	1677 (aa)	XP_005267292	Q02952

Gene Model

Click here to download 's gene model file

Phenotype

ensgID	Trait	pValue	Pubmed ID
ENSG00000131016	Abdominal Fat	9.05760492161663E-6	17903300
ENSG00000131016	Waist-Hip Ratio	2.5530000E-005	-
ENSG00000131016	Platelet Function Tests	6.4900000E-006	-
ENSG00000131016	Platelet Function Tests	1.8772000E-005	-

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000131016	rs6929715	6	151247738	?	Alzheimer's disease progression score	29860282	[NR] unit decrease	0.05	EFO_0006514
ENSG00000131016	rs12175863	6	151262834	?	Peripheral arterial disease (traffic-related air pollution interaction)	27082954	[20.79-25.77]	23.28	EFO_0004265\|EFO_0007908
ENSG00000131016	rs200662204	6	151351815	G	Heel bone mineral density	30598549	[0.15-0.3] unit decrease	0.225037	EFO_0009270
ENSG00000131016	rs7773781	6	151240978	G	Male-pattern baldness	30573740	[0.012-0.026] unit decrease	0.0193578	EFO_0007825
ENSG00000131016	rs4869723	6	151258297	T	Blond vs. brown/black hair color	30531825	NR	1.058	EFO_0003924
ENSG00000131016	rs9397040	6	151259630	A	Brown vs. black hair color	30531825	NR	1.079	EFO_0003924
ENSG00000131016	rs10434895	6	151256604	?	Hair color	30595370			EFO_0007822

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000131016's network

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0005515	protein binding	20029029.	IPI	Function
GO:0005737	cytoplasm	10858453.	TAS	Component
GO:0005829	cytosol	-	IDA	Component
GO:0005856	cytoskeleton	-	IEA	Component
GO:0005886	plasma membrane	-	IDA	Component
GO:0005925	focal adhesion	21423176.	HDA	Component
GO:0005938	cell cortex	-	IEA	Component
GO:0006605	protein targeting	-	IEA	Process
GO:0007186	G protein-coupled receptor signaling pathway	10858453.	TAS	Process
GO:0007193	adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	17081159.	IMP	Process
GO:0008179	adenylate cyclase binding	17081159.	IPI	Function
GO:0010738	regulation of protein kinase A signaling	17081159.	IMP	Process
GO:0010739	positive regulation of protein kinase A signaling	-	IEA	Process
GO:0050804	modulation of chemical synaptic transmission	-	IEA	Process
GO:0051018	protein kinase A binding	-	IEA	Function
GO:0090036	regulation of protein kinase C signaling	-	IEA	Process
GO:0098685	Schaffer collateral - CA1 synapse	-	IEA	Component

EuRBPDB

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Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Expression

Transcripts

Gene Model

Phenotype

GWAS

PPI

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.