EuRBPDB

  • Home
  • Cancer
  • Family
  • Species
  • RBPredictor
  • Search
  • Download
  • Submit
  • Help
  • Contact
TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
26411419PAK4 confers the malignance of cervical cancers and contributes to the cisplatin-resistance in cervical cancer cells via PI3K/AKT pathway.Diagn Pathol2015 Sep 28Shu XRdoi: 10.1186/s13000-015-0404-z.
22710715p21-Activated kinase 4 promotes prostate cancer progression through CREB.Oncogene2013 May 9Park MHdoi: 10.1038/onc.2012.255
22766504MiR-145 regulates PAK4 via the MAPK pathway and exhibits an antitumor effect in human colon cells.Biochem Biophys Res Commun2012 Oct 26Wang Zdoi: 10.1016/j.bbrc.2012.06.123
28393218P21 activated kinase 4 binds translation elongation factor eEF1A1 to promote gastric cancer cell migration and invasion.Oncol Rep2017 MayLi Xdoi: 10.3892/or.2017.5543
28542136PAK4 regulates G6PD activity by p53 degradation involving colon cancer cell growth.Cell Death Dis2017 May 25Zhang Xdoi: 10.1038/cddis.2017.85.
30177834A mandatory role of nuclear PAK4-LIFR axis in breast-to-bone metastasis of ERα-positive breast cancer cells.Oncogene2019 FebLi Ydoi: 10.1038/s41388-018-0456-0
20406887PAK4: a pluripotent kinase that regulates prostate cancer cell adhesion.J Cell Sci2010 May 15Wells CMdoi: 10.1242/jcs.055707
20501374[Expression of PAK4 in breast cancer and benign breast pathological changes].Nan Fang Yi Ke Da Xue Xue Bao2010 MayYang JX-
26546043p-21 activated kinase 4 (PAK4) maintains stem cell-like phenotypes in pancreatic cancer cells through activation of STAT3 signaling.Cancer Lett2016 Jan 28Tyagi Ndoi: 10.1016/j.canlet.2015.10.028
22085492LCH-7749944, a novel and potent p21-activated kinase 4 inhibitor, suppresses proliferation and invasion in human gastric cancer cells.Cancer Lett2012 Apr 1Zhang Jdoi: 10.1016/j.canlet.2011.11.007
26124003Activated Pak4 expression correlates with poor prognosis in human gastric cancer patients.Tumour Biol2015 DecLi Ddoi: 10.1007/s13277-015-3368-4
19778628DGCR6L, a novel PAK4 interaction protein, regulates PAK4-mediated migration of human gastric cancer cell via LIMK1.Int J Biochem Cell Biol2010 JanLi Xdoi: 10.1016/j.biocel.2009.09.008
23893240PAK4 kinase-mediated SCG10 phosphorylation involved in gastric cancer metastasis.Oncogene2014 Jun 19Guo Qdoi: 10.1038/onc.2013.296
25791829P21-activated kinase 1 and 4 were associated with colorectal cancer metastasis and infiltration.J Surg Res2015 Jun 1Song Bdoi: 10.1016/j.jss.2015.02.035
27297086Study on the expression of PAK4 and P54 protein in breast cancer.World J Surg Oncol2016 Jun 13Bi Ydoi: 10.1186/s12957-016-0913-6.
26218748p21-Activated Kinases 1, 2 and 4 in Endometrial Cancers: Effects on Clinical Outcomes and Cell Proliferation.PLoS One2015 Jul 28Siu MKdoi: 10.1371/journal.pone.0133467
26614788Prognostic significance of PAK4 expression in gastric cancer.J Clin Pathol2016 JulKobayashi Kdoi: 10.1136/jclinpath-2015-203330
19050074Genomic alterations link Rho family of GTPases to the highly invasive phenotype of pancreas cancer.Proc Natl Acad Sci U S A2008 Dec 9Kimmelman ACdoi: 10.1073/pnas.0809966105
23934187Oncogenic PAK4 regulates Smad2/3 axis involving gastric tumorigenesis.Oncogene2014 Jun 26Wang Cdoi: 10.1038/onc.2013.300
23790167p21-activated kinase 4 regulation of endometrial cancer cell migration and invasion involves the ERK1/2 pathway mediated MMP-2 secretion.Neoplasma2013Lu Wdoi: 10.4149/neo_2013_064.
20926745p21-activated kinase 4 regulates ovarian cancer cell proliferation, migration, and invasion and contributes to poor prognosis in patients.Proc Natl Acad Sci U S A2010 Oct 26Siu MKdoi: 10.1073/pnas.0907481107
25238288p-21 activated kinase 4 promotes proliferation and survival of pancreatic cancer cells through AKT- and ERK-dependent activation of NF-??B pathway.Oncotarget2014 Sep 30Tyagi N-
28288786p21-activated kinase 4 regulates HIF-1α translation in cancer cells.Biochem Biophys Res Commun2017 Apr 29Kim Hdoi: 10.1016/j.bbrc.2017.03.024
28407679Activated-PAK4 predicts worse prognosis in breast cancer and promotes tumorigenesis through activation of PI3K/AKT signaling.Oncotarget2017 Mar 14He LFdoi: 10.18632/oncotarget.7466.
28440035MiR-145 inhibits human colorectal cancer cell migration and invasion via PAK4-dependent pathway.Cancer Med2017 JunSheng Ndoi: 10.1002/cam4.1029
28178642P21-activated kinase 4 involves TSH induced papillary thyroid cancer cell proliferation.Oncotarget2017 Apr 11Xie Xdoi: 10.18632/oncotarget.15079.

Differential Expression

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
BLCAchr19391785993'UTRnovel0.45
BLCAchr1939169599Missense_MutationNAN16H0.38
BLCAchr19391786353'UTRnovel0.29
BRCAchr1939169588Missense_MutationNAS12F0.29
BRCAchr1939169628Silentrs113813881F25F0.16
CESCchr1939173575Splice_SitenovelX223_splice0.49
CESCchr19391785913'UTRrs7746368000.13
CESCchr1939169712Silentrs377525201L53L0.44
CESCchr1939173103SilentnovelG130G0.56
CESCchr19391792723'UTRnovel0.4
CESCchr1939173673Missense_Mutationrs764392821R254Q0.16
CESCchr1939177726Frame_Shift_DelNAY515Tfs*100.26
CESCchr1939178489Silentrs55747949T562T0.43
CESCchr1939173649Missense_MutationNAS246F0.37
CESCchr19391785993'UTRnovel0.26
COADchr1939178429SilentNAS542S0.38
COADchr1939175365Missense_Mutationrs377696830S429L0.38
COADchr1939177688Missense_Mutationrs774651046S500L0.39
COADchr1939178429SilentNAS542S0.5
COADchr1939175408Silentrs141004307S443S0.07
COADchr1939178471SilentNAD556D0.13
COADchr1939169566Missense_MutationNAR5G0.25
COADchr1939173142Missense_MutationNAE143D0.32
COADchr1939173273Frame_Shift_DelNAQ189Sfs*1800.6
COADchr1939173857SilentNAG315G0.36
COADchr1939176617Missense_MutationNAA463T0.16
COADchr1939173273Frame_Shift_DelNAQ189Sfs*1800.34
COADchr1939173273Frame_Shift_DelNAQ189Sfs*1800.38
COADchr1939178560Missense_Mutationrs747655225R586H0.19
COADchr1939173273Frame_Shift_DelNAQ189Sfs*1800.44
COADchr1939176663Missense_MutationNAT478M0.1
COADchr1939176641Nonsense_MutationNAR471*0.08
COADchr1939173037Silentrs55711468P108P0.33
COADchr1939173034SilentNAP107P0.31
COADchr1939169746Frame_Shift_DelNAA66Pfs*290.29
COADchr1939177719Silentrs749356499D510D0.43
DLBCchr1939169652Silentrs757615009T33T0.21
ESCAchr1939173084Missense_MutationnovelT124M0.14
ESCAchr1939175000Missense_Mutationrs780200774E390K0.22
GBMchr1939175384Silentrs757293101G435G0.31
GBMchr1939174985Missense_MutationNAY385H0.32
GBMchr1939173339Missense_MutationnovelP209L0.1
HNSCchr1939169673SilentnovelQ40Q0.43
HNSCchr1939169534Splice_Regionrs3766213370.23
HNSCchr1939173787Missense_MutationnovelP292L0.41
KIRCchr1939175377Missense_MutationnovelA433V0.33
KIRCchr1939177717Missense_MutationNAD510N0.39
KIRCchr1939173852Missense_MutationNAP314T0.2
KIRPchr1939176627Missense_MutationNAS466I0.42
KIRPchr1939172930Missense_MutationnovelG73R0.38
LGGchr1939173635Missense_MutationNAQ241H0.09
LIHCchr1939173617SilentnovelG235G0.61
LIHCchr19391786323'UTRnovel0.53
LIHCchr1939177701Missense_MutationnovelM504I0.34
LIHCchr1939172929SilentnovelR72R0.41
LIHCchr1939175000Nonsense_MutationnovelE390*0.09
LIHCchr1939169576Missense_MutationNAR8Q0.18
LUADchr1939173320Missense_Mutationrs370979504R203W0.47
LUADchr1939169721Silentrs764654285P56P0.29
LUADchr1939178539Missense_MutationnovelA579D0.3
LUADchr1939169617Missense_MutationnovelH22Y0.17
LUADchr1939173365Missense_MutationNAR218W0.17
LUADchr1939174958Missense_Mutationrs375220515E376K0.42
LUADchr1939175005SilentnovelL391L0.2
LUADchr1939176622Missense_MutationnovelQ464H0.26
LUADchr1939169534Splice_Regionrs3766213370.36
LUSCchr1939169653Missense_MutationnovelG34W0.15
LUSCchr1939173993Nonsense_MutationnovelE361*0.35
LUSCchr1939178574Nonsense_MutationNAR591*0.48
OVchr1939169631Missense_MutationnovelD26E0.21
OVchr1939178501SilentNAL566L0.33
PAADchr1939176658Silentrs201757969V476V0.17
PAADchr1939176673Nonsense_MutationnovelW481*0.21
READchr1939173273Frame_Shift_DelNAQ189Sfs*1800.19
SARCchr19391786853'UTRnovel0.22
SKCMchr1939173595Missense_MutationnovelA228G0.35
SKCMchr1939173596SilentnovelA228A0.32
SKCMchr1939169649SilentNAF32F0.24
SKCMchr1939178428Missense_MutationNAS542L0.57
SKCMchr1939169713Missense_MutationNAV54F0.36
SKCMchr1939176666Missense_MutationNAP479L0.19
SKCMchr1939173687Missense_MutationNAP259S0.44
SKCMchr1939177731Silentrs146955542P514P0.42
SKCMchr1939176678Missense_MutationnovelA483V0.27
SKCMchr1939176679SilentNAA483A0.27
SKCMchr1939178511Missense_MutationnovelP570S0.41
SKCMchr19391695445'UTRrs7752886780.33
SKCMchr19391695535'UTRnovel0.13
SKCMchr1939176702Missense_MutationNAP491L0.09
SKCMchr1939173665SilentnovelT251T0.41
SKCMchr1939169744Missense_MutationNAP64L0.43
STADchr1939173991Missense_Mutationrs777017835R360H0.53
STADchr1939176663Missense_MutationNAT478M0.19
STADchr1939176677Missense_Mutationrs780795083A483T0.43
STADchr1939177725Frame_Shift_Insrs769136911Y515Lfs*1240.57
STADchr1939176703SilentNAP491P0.32
STADchr1939176680Missense_MutationnovelP484S0.4
STADchr1939178533Missense_Mutationrs762977178P577L0.21
STADchr1939178569Missense_MutationNAR589H0.24
UCECchr1939173034SilentNAP107P0.25
UCECchr19391695355'UTRrs3700089290.44
UCECchr1939169691SilentnovelS46S0.33
UCECchr19391791093'UTRnovel0.36
UCECchr1939169593Missense_MutationnovelP14S0.4
UCECchr1939176657Missense_MutationnovelV476D0.44
UCECchr1939177773Silentrs767808811R528R0.31
UCECchr19391789913'UTRrs7572239090.39
UCECchr19391792883'UTRnovel0.46
UCECchr19391793333'UTRnovel0.23
UCECchr1939178490Missense_MutationnovelA563T0.42
UCECchr1939175324SilentNAE415E0.38
UCECchr1939169629Missense_MutationnovelD26N0.09
UCECchr1939172937Missense_MutationnovelK75T0.14
UCECchr1939173042Missense_Mutationrs763084575R110H0.55
UCECchr1939173151Silentrs761695934G146G0.69
UCECchr1939175050Silentrs372653621I406I0.52
UCECchr1939176651Missense_Mutationrs776546703S474L0.37
UCECchr1939176651Missense_Mutationrs776546703S474L0.47
UCECchr1939177675Missense_Mutationrs746034918V496I0.35
UCECchr1939173126Missense_MutationnovelF138S0.28
UCECchr1939175409Missense_Mutationrs760075494D444N0.32
UCECchr1939172997Missense_MutationnovelT95I0.35
UCECchr1939175324SilentNAE415E0.75
UCECchr1939176709SilentnovelG493G0.24
UCECchr1939175428Missense_MutationnovelH450R0.22
UCECchr1939173635SilentnovelQ241Q0.25
UCSchr1939173628Frame_Shift_InsnovelQ241Pfs*620.55
UCSchr1939169688Missense_MutationnovelE45D0.71

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
KIRPDEL0.04510.054726
OVAMP0.36442.2539e-28
READDEL0.05450.23023
UCSDEL0.1250.12448

Survival Analysis
CancerP-value Q-value
THYM0.049

Kaplan-Meier Survival Analysis

MESO0.038

Kaplan-Meier Survival Analysis

ACC0.00062

Kaplan-Meier Survival Analysis

SKCM0.00012

Kaplan-Meier Survival Analysis

PRAD0.016

Kaplan-Meier Survival Analysis

TGCT0.042

Kaplan-Meier Survival Analysis

KICH0.0043

Kaplan-Meier Survival Analysis

UCEC0.029

Kaplan-Meier Survival Analysis

LIHC0.0099

Kaplan-Meier Survival Analysis

LGG0.00011

Kaplan-Meier Survival Analysis

LUAD0.0028

Kaplan-Meier Survival Analysis

OV0.048

Kaplan-Meier Survival Analysis

Drugs

Select Dataset :


Input Drug :


Input Cell Line :


Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBPome
  • Expression
  • Transcripts
  • Gene Model
  • Pathways
  • PPI
  • Gene Ontology
Description
Ensembl ID
ENSG00000130669 (Gene tree)
Gene ID
10298
Gene Symbol
PAK4
Alias
N
Full Name
p21 (RAC1) activated kinase 4
Gene Type
protein_coding
Species
Homo_sapiens
Status
putative
Strand
Plus strand
Length
57,047 bases
Position
chr19:39,125,770-39,182,816
Accession
16059
RBP type
non-canonical RBP
Summary
PAK proteins, a family of serine/threonine p21-activating kinases, include PAK1, PAK2, PAK3 and PAK4. PAK proteins are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. They serve as targets for the small GTP binding proteins Cdc42 and Rac and have been implicated in a wide range of biological activities. PAK4 interacts specifically with the GTP-bound form of Cdc42Hs and weakly activates the JNK family of MAP kinases. PAK4 is a mediator of filopodia formation and may play a role in the reorganization of the actin cytoskeleton. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & HEK2932019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & MCF72018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000360442PAK4-2032855-ENSP00000353625591 (aa)-O96013
ENST00000600350PAK4-211549--- (aa)--
ENST00000602004PAK4-212564-ENSP00000471318182 (aa)-M0R0L9
ENST00000593480PAK4-204714-ENSP00000472862131 (aa)-M0R2X4
ENST00000593690PAK4-2053025XM_011526316ENSP00000469413591 (aa)XP_011524618O96013
ENST00000599470PAK4-2091715-ENSP00000470284438 (aa)-O96013
ENST00000597715PAK4-206633-ENSP00000472061149 (aa)-M0R1R1
ENST00000599386PAK4-2085735XM_011526320ENSP00000471157438 (aa)XP_011524622O96013
ENST00000321944PAK4-2012555-ENSP00000326864501 (aa)-O96013
ENST00000599657PAK4-210534-ENSP0000047321593 (aa)-M0R3G6
ENST00000358301PAK4-2022739-ENSP00000351049591 (aa)-O96013
ENST00000597766PAK4-207380--- (aa)--
Gene Model
Click here to download ENSG00000130669's gene model file
Pathways
Pathway IDPathway NameSource
hsa04012ErbB signaling pathwayKEGG
hsa04014Ras signaling pathwayKEGG
hsa04360Axon guidanceKEGG
hsa04510Focal adhesionKEGG
hsa04660T cell receptor signaling pathwayKEGG
hsa04810Regulation of actin cytoskeletonKEGG
hsa05170Human immunodeficiency virus 1 infectionKEGG
hsa05206MicroRNAs in cancerKEGG
hsa05211Renal cell carcinomaKEGG
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000130669's network

* RBP PPI network refers to all genes directly bind to RBP
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0001558regulation of cell growth20070256.TASProcess
GO:0004672protein kinase activity9822598.NASFunction
GO:0004674protein serine/threonine kinase activity21873635.IBAFunction
GO:0004674protein serine/threonine kinase activity26607847.IDAFunction
GO:0004674protein serine/threonine kinase activity21788589.IMPFunction
GO:0005515protein binding20936779.21044950.22653441.24130170.25074804.26607847.IPIFunction
GO:0005524ATP binding-IEAFunction
GO:0005737cytoplasm21873635.IBAComponent
GO:0005794Golgi apparatus9822598.TASComponent
GO:0005913cell-cell adherens junction25468996.HDAComponent
GO:0005925focal adhesion21423176.HDAComponent
GO:0006915apoptotic process20070256.TASProcess
GO:0007010cytoskeleton organization20070256.TASProcess
GO:0007049cell cycle-IEAProcess
GO:0007165signal transduction20070256.TASProcess
GO:0008283cell proliferation20070256.TASProcess
GO:0016477cell migration21873635.IBAProcess
GO:0016477cell migration20070256.TASProcess
GO:0023014signal transduction by protein phosphorylation21873635.IBAProcess
GO:0031098stress-activated protein kinase signaling cascade21873635.IBAProcess
GO:0032147activation of protein kinase activity21873635.IBAProcess
GO:0043408regulation of MAPK cascade21873635.IBAProcess
GO:0045766positive regulation of angiogenesis21788589.IMPProcess
GO:0048365Rac GTPase binding21873635.IBAFunction
GO:0060996dendritic spine development-IEAProcess
GO:0071407cellular response to organic cyclic compound-IEAProcess
GO:0098609cell-cell adhesion-IEAProcess
GO:0098641cadherin binding involved in cell-cell adhesion25468996.HDAFunction
GO:2000352negative regulation of endothelial cell apoptotic process21788589.IMPProcess
To top

Copyright © , Bioinformatics Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, China. All Rights Reserved.

Any comment and suggestion, please contact us