EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
27121206	Efficacy of adjuvant chemotherapy for non-small cell lung cancer assessed by metastatic potential associated with ACTN4.	Oncotarget	2016 May 31	Miura N	doi: 10.18632/oncotarget.8890.
19151661	Actinin-4 gene amplification in ovarian cancer: a candidate oncogene associated with poor patient prognosis and tumor chemoresistance.	Mod Pathol	2009 Apr	Yamamoto S	doi: 10.1038/modpathol.2008.234
15493875	Non-muscle alpha-actinin-4 interacts with plasminogen activator inhibitor type-1 (PAI-1).	Biol Chem	2004 Sep	Magdolen U	-
21408150	HAMLET binding to α-actinin facilitates tumor cell detachment.	PLoS One	2011 Mar 8	Trulsson M	doi: 10.1371/journal.pone.0017179.
27065319	α-Actinin-4 induces the epithelial-to-mesenchymal transition and tumorigenesis via regulation of Snail expression and β-catenin stabilization in cervical cancer.	Oncogene	2016 Nov 10	An HT	doi: 10.1038/onc.2016.117
28385383	Prognostic significance of gene amplification of ACTN4 in stage I and II oral tongue cancer.	Int J Oral Maxillofac Surg	2017 Aug	Kakuya T	doi: 10.1016/j.ijom.2017.03.001
29921500	Measurement of copy number of ACTN4 to optimize the therapeutic strategy for locally advanced pancreatic cancer.	Pancreatology	2018 Sep	Shoji H	doi: 10.1016/j.pan.2018.06.003
25299231	Alpha-actinin 4 is associated with cancer cell motility and is a potential biomarker in non-small cell lung cancer.	J Thorac Oncol	2015 Feb	Wang MC	doi: 10.1097/JTO.0000000000000396.
25216292	Estrogen stimulates the invasion of ovarian cancer cells via activation of the PI3K/AKT pathway and regulation of its downstream targets Ecadherin and αactinin4.	Mol Med Rep	2014 Nov	Lu Z	doi: 10.3892/mmr.2014.2561
21078666	The actin-binding protein, actinin alpha 4 (ACTN4), is a nuclear receptor coactivator that promotes proliferation of MCF-7 breast cancer cells.	J Biol Chem	2011 Jan 21	Khurana S	doi: 10.1074/jbc.M110.162107
19913389	RNAi-mediated down-regulation of alpha-actinin-4 decreases invasion potential in oral squamous cell carcinoma.	Int J Oral Maxillofac Surg	2010 Jan	Yamada S	doi: 10.1016/j.ijom.2009.10.003
23810014	Alpha-actinin 4 and tumorigenesis of breast cancer.	Vitam Horm	2013	Hsu KS	doi: 10.1016/B978-0-12-416673-8.00005-8.
25885339	ACTN4 and the pathways associated with cell motility and adhesion contribute to the process of lung cancer metastasis to the brain.	BMC Cancer	2015 Apr 12	Gao Y	doi: 10.1186/s12885-015-1295-9.
23817592	Increased expression of α-actinin-4 is associated with unfavorable pathological features and invasiveness of bladder cancer.	Oncol Rep	2013 Sep	Yoshii H	doi: 10.3892/or.2013.2577
25602965	ACTN4 copy number increase as a predictive biomarker for chemoradiotherapy of locally advanced pancreatic cancer.	Br J Cancer	2015 Feb 17	Watanabe T	doi: 10.1038/bjc.2014.623
24922688	Histological growth pattern of and alpha-actinin-4 expression in thyroid cancer.	Anticancer Res	2014 Jun	Tanaka N	-
29055790	α-Actinin-4 confers radioresistance coupled invasiveness in breast cancer cells through AKT pathway.	Biochim Biophys Acta Mol Cell Res	2018 Jan	Desai S	doi: 10.1016/j.bbamcr.2017.10.006

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr19	38724175	Missense_Mutation	novel	D571Y	0.19
BLCA	chr19	38727949	Missense_Mutation	novel	H781Y	0.24
BLCA	chr19	38717989	Silent	NA	L402L	0.24
BLCA	chr19	38725726	Missense_Mutation	novel	E671D	0.15
BLCA	chr19	38729289	Missense_Mutation	novel	E865Q	0.39
BLCA	chr19	38729377	Missense_Mutation	NA	G894D	0.2
BLCA	chr19	38701111	Silent	rs550083317	I129I	0.34
BLCA	chr19	38729129	Missense_Mutation	NA	S851F	0.11
BLCA	chr19	38729401	Missense_Mutation	novel	S902C	0.25
BLCA	chr19	38721651	Missense_Mutation	rs752441330	R469C	0.32
BLCA	chr19	38709449	Missense_Mutation	NA	D236N	0.17
BRCA	chr19	38729061	Frame_Shift_Del	NA	*Q829Kfs27**	0.33
BRCA	chr19	38723686	Silent	rs147922933	L505L	0.2
BRCA	chr19	38700667	Missense_Mutation	novel	D77G	0.19
BRCA	chr19	38717152	Missense_Mutation	NA	E327K	0.42
BRCA	chr19	38723677	Missense_Mutation	novel	W502C	0.18
BRCA	chr19	38729786	3'UTR	novel		0.4
BRCA	chr19	38727040	Silent	rs767071822	D758D	0.11
BRCA	chr19	38725874	Missense_Mutation	NA	D721Y	0.2
BRCA	chr19	38717993	Missense_Mutation	novel	E404Q	0.21
BRCA	chr19	38730483	3'UTR	novel		0.04
BRCA	chr19	38727011	Missense_Mutation	novel	E749K	0.12
BRCA	chr19	38706095	Missense_Mutation	NA	P179R	0.28
BRCA	chr19	38717266	Missense_Mutation	rs752211925	R365C	0.3
CESC	chr19	38729070	Silent	NA	F831F	0.52
CESC	chr19	38730544	3'UTR	novel		0.42
CESC	chr19	38730677	3'UTR	novel		0.52
CESC	chr19	38726975	Missense_Mutation	NA	E737K	0.22
CESC	chr19	38718071	Missense_Mutation	novel	D430N	0.18
CESC	chr19	38729065	Missense_Mutation	novel	A830T	0.09
CESC	chr19	38729066	Missense_Mutation	novel	A830V	0.08
CESC	chr19	38729055	Silent	NA	V826V	0.19
CESC	chr19	38729289	Nonsense_Mutation	NA	E865*	0.11
CESC	chr19	38701068	Missense_Mutation	novel	A115V	0.46
CESC	chr19	38723629	Silent	rs372458891	Y486Y	0.43
CESC	chr19	38729336	Silent	rs565687082	I880I	0.29
CESC	chr19	38710283	Missense_Mutation	novel	E254K	0.23
COAD	chr19	38708147	Silent	NA	L201L	0.15
COAD	chr19	38724024	Missense_Mutation	rs762475438	A547T	0.38
COAD	chr19	38729097	Silent	rs372396071	T840T	0.1
COAD	chr19	38724017	Missense_Mutation	novel	M544I	0.06
COAD	chr19	38729087	Missense_Mutation	rs368563044	R837Q	0.41
COAD	chr19	38729337	Missense_Mutation	rs148628123	A881T	0.26
COAD	chr19	38729084	Missense_Mutation	rs766882748	S836L	0.33
COAD	chr19	38724510	Missense_Mutation	novel	R652H	0.32
COAD	chr19	38724043	Missense_Mutation	novel	D553G	0.07
COAD	chr19	38700677	Silent	NA	D80D	0.28
COAD	chr19	38725863	Missense_Mutation	novel	A717V	0.11
COAD	chr19	38704945	Missense_Mutation	rs375921941	G137S	0.32
COAD	chr19	38714562	Splice_Site	NA	X304_splice	0.15
COAD	chr19	38701121	Nonsense_Mutation	novel	E133*	0.38
COAD	chr19	38728008	Silent	rs138139611	D800D	0.14
COAD	chr19	38701007	Missense_Mutation	rs771850037	R95W	0.17
ESCA	chr19	38718000	Missense_Mutation	novel	R406H	0.17
ESCA	chr19	38730548	3'UTR	novel		0.26
ESCA	chr19	38718043	Silent	novel	Q420Q	0.28
ESCA	chr19	38730819	3'UTR	novel		0.18
ESCA	chr19	38708154	Missense_Mutation	novel	R204W	0.22
GBM	chr19	38729103	Silent	rs375763862	T842T	0.36
GBM	chr19	38729337	Missense_Mutation	rs148628123	A881T	0.24
GBM	chr19	38725796	Missense_Mutation	rs769829818	R695C	0.72
GBM	chr19	38729010	Silent	NA	F811F	0.34
GBM	chr19	38717180	Missense_Mutation	novel	R336H	0.25
GBM	chr19	38723712	Missense_Mutation	novel	E514V	0.19
GBM	chr19	38714543	Silent	rs568574676	Y298Y	0.12
HNSC	chr19	38723717	Missense_Mutation	novel	L516M	0.38
HNSC	chr19	38724452	Missense_Mutation	novel	R633W	0.17
HNSC	chr19	38729091	Missense_Mutation	novel	E838D	0.09
HNSC	chr19	38701101	Missense_Mutation	novel	L126Q	0.29
HNSC	chr19	38724281	Missense_Mutation	rs747590691	S606L	0.31
KICH	chr19	38726990	Missense_Mutation	novel	T742A	0.37
KIRC	chr19	38725723	Splice_Site	NA	X671_splice	0.42
KIRC	chr19	38714538	Missense_Mutation	NA	D297N	0.06
KIRC	chr19	38724197	Missense_Mutation	NA	P578L	0.31
KIRC	chr19	38729309	Frame_Shift_Ins	novel	*D874Rfs17**	0.4
KIRP	chr19	38724026	Silent	novel	A547A	0.33
KIRP	chr19	38729461	3'UTR	rs773633620		0.44
KIRP	chr19	38729051	Missense_Mutation	novel	L825P	0.46
LGG	chr19	38721640	Missense_Mutation	rs753703237	A465V	0.24
LGG	chr19	38724061	Missense_Mutation	novel	T559N	0.41
LIHC	chr19	38717205	Silent	rs753535029	P344P	0.08
LUAD	chr19	38721668	Silent	rs149647148	A474A	0.08
LUAD	chr19	38723952	Silent	NA	L523L	0.45
LUAD	chr19	38717152	Missense_Mutation	NA	E327K	0.23
LUAD	chr19	38724214	Missense_Mutation	rs376144793	R584C	0.07
LUAD	chr19	38729376	Missense_Mutation	rs141002044	G894S	0.14
LUAD	chr19	38729309	Frame_Shift_Ins	novel	*D874Rfs17**	0.27
LUAD	chr19	38647825	Missense_Mutation	novel	S27I	0.67
LUAD	chr19	38717235	Missense_Mutation	novel	E354D	0.43
LUAD	chr19	38729044	Missense_Mutation	NA	S823C	0.57
LUAD	chr19	38710270	Silent	novel	T249T	0.18
LUSC	chr19	38723705	Missense_Mutation	NA	R512G	0.28
LUSC	chr19	38717170	Nonsense_Mutation	NA	E333*	0.42
LUSC	chr19	38710342	Splice_Region	novel	K273K	0.4
LUSC	chr19	38724517	Silent	novel	F654F	0.4
LUSC	chr19	38724429	Splice_Site	novel	X626_splice	0.19
LUSC	chr19	38724555	Missense_Mutation	NA	T667N	0.26
LUSC	chr19	38729460	3'UTR	rs772612410		0.19
LUSC	chr19	38725840	Missense_Mutation	novel	Q709H	0.35
LUSC	chr19	38706066	Silent	NA	L169L	0.14
LUSC	chr19	38706067	Missense_Mutation	NA	L170F	0.14
LUSC	chr19	38700625	Missense_Mutation	novel	H63L	0.29
LUSC	chr19	38721646	Missense_Mutation	NA	Q467R	0.22
LUSC	chr19	38717092	Nonsense_Mutation	novel	E307*	0.17
LUSC	chr19	38718051	Missense_Mutation	novel	S423C	0.41
LUSC	chr19	38724217	Missense_Mutation	rs759789993	E585K	0.24
MESO	chr19	38723705	Missense_Mutation	rs778312331	R512C	0.1
OV	chr19	38725745	Missense_Mutation	novel	E678K	0.22
OV	chr19	38724238	Missense_Mutation	novel	K592E	0.16
OV	chr19	38717290	Frame_Shift_Ins	novel	*M373Tfs31**	0.33
PRAD	chr19	38700607	Missense_Mutation	rs768656011	T57M	0.35
PRAD	chr19	38717128	Missense_Mutation	novel	R319C	0.38
PRAD	chr19	38728017	Silent	rs767454781	N803N	0.39
PRAD	chr19	38729368	Missense_Mutation	novel	A891V	0.38
READ	chr19	38721629	Silent	rs750702920	S461S	0.35
READ	chr19	38724050	Missense_Mutation	NA	F555L	0.38
READ	chr19	38708147	Silent	NA	L201L	0.44
READ	chr19	38706108	Silent	novel	V183V	0.12
SARC	chr19	38724191	Missense_Mutation	novel	T576I	0.38
SARC	chr19	38730534	3'UTR	novel		0.44
SARC	chr19	38704998	Silent	novel	A154A	0.46
SARC	chr19	38723936	Splice_Site	novel	X518_splice	0.26
SARC	chr19	38724075	Missense_Mutation	novel	E564Q	0.34
SARC	chr19	38710275	Missense_Mutation	rs561181666	R251Q	0.26
SARC	chr19	38721757	Intron	novel		0.83
SKCM	chr19	38724551	Nonsense_Mutation	NA	Q666*	0.35
SKCM	chr19	38721704	Intron	novel		0.28
SKCM	chr19	38729129	Missense_Mutation	NA	S851F	0.19
SKCM	chr19	38724466	Silent	novel	L637L	0.45
SKCM	chr19	38700699	Silent	novel	L88L	0.48
SKCM	chr19	38717114	Missense_Mutation	NA	P314L	0.4
SKCM	chr19	38721689	Splice_Site	NA	X481_splice	0.26
SKCM	chr19	38700672	Nonsense_Mutation	NA	R79*	0.16
SKCM	chr19	38724235	Missense_Mutation	NA	H591Y	0.22
SKCM	chr19	38701108	Silent	novel	S128S	0.48
STAD	chr19	38717182	Missense_Mutation	NA	D337N	0.1
STAD	chr19	38729392	Missense_Mutation	novel	K899R	0.07
STAD	chr19	38717301	Silent	NA	E376E	0.5
STAD	chr19	38700673	Missense_Mutation	rs759055242	R79Q	0.35
STAD	chr19	38717249	Missense_Mutation	NA	T359M	0.32
STAD	chr19	38724440	Silent	NA	L629L	0.14
STAD	chr19	38729405	Silent	rs760996008	T903T	0.34
STAD	chr19	38729310	Frame_Shift_Del	NA	*D874Tfs44**	0.35
STAD	chr19	38717280	Silent	NA	R369R	0.12
STAD	chr19	38727955	Missense_Mutation	rs778422858	G783R	0.31
STAD	chr19	38723680	Silent	rs750084549	D503D	0.3
STAD	chr19	38706112	Missense_Mutation	novel	V185M	0.17
STAD	chr19	38727953	Missense_Mutation	novel	G782D	0.4
STAD	chr19	38728013	Missense_Mutation	NA	E802A	0.11
STAD	chr19	38729125	Missense_Mutation	rs376869655	A850T	0.21
STAD	chr19	38724197	Missense_Mutation	NA	P578L	0.24
STAD	chr19	38717191	Missense_Mutation	rs760523958	R340C	0.33
STAD	chr19	38724303	Silent	NA	T613T	0.21
STAD	chr19	38709427	Silent	rs763760070	F228F	0.46
STAD	chr19	38723991	Missense_Mutation	rs372902386	R536C	0.48
UCEC	chr19	38730715	3'UTR	novel		0.38
UCEC	chr19	38709427	Silent	rs763760070	F228F	0.33
UCEC	chr19	38700631	Missense_Mutation	novel	R65Q	0.22
UCEC	chr19	38709427	Silent	rs763760070	F228F	0.4
UCEC	chr19	38717147	Missense_Mutation	novel	I325S	0.32
UCEC	chr19	38709427	Silent	rs763760070	F228F	0.13
UCEC	chr19	38730431	3'UTR	novel		0.42
UCEC	chr19	38729284	Missense_Mutation	novel	T863I	0.07
UCEC	chr19	38730431	3'UTR	novel		0.35
UCEC	chr19	38709427	Silent	rs763760070	F228F	0.12
UCEC	chr19	38710261	Silent	rs34491236	I246I	0.38
UCEC	chr19	38714522	Silent	rs374240674	N291N	0.33
UCEC	chr19	38723629	Silent	rs372458891	Y486Y	0.42
UCEC	chr19	38717266	Missense_Mutation	rs752211925	R365C	0.41
UCEC	chr19	38710261	Silent	rs34491236	I246I	0.18
UCEC	chr19	38717249	Missense_Mutation	NA	T359M	0.29
UCEC	chr19	38721624	Missense_Mutation	rs767795519	E460K	0.27
UCEC	chr19	38724249	Silent	NA	Q595Q	0.24
UCEC	chr19	38724542	Missense_Mutation	NA	P663S	0.29
UCEC	chr19	38730431	3'UTR	novel		0.52
UCEC	chr19	38714480	Silent	rs773662358	A277A	0.34
UCEC	chr19	38724255	Silent	rs780958051	I597I	0.32
UCEC	chr19	38704979	Missense_Mutation	NA	T148I	0.28
UCEC	chr19	38717176	Missense_Mutation	NA	F335V	0.19
UCEC	chr19	38717134	Frame_Shift_Del	novel	*Q322Kfs81**	0.41
UCEC	chr19	38730431	3'UTR	novel		0.53
UCEC	chr19	38709428	Missense_Mutation	novel	E229K	0.2
UCEC	chr19	38710319	Missense_Mutation	novel	H266Y	0.3
UCEC	chr19	38729014	Missense_Mutation	rs755524840	R813C	0.28
UCEC	chr19	38730431	3'UTR	novel		0.94
UCEC	chr19	38730314	3'UTR	novel		0.17
UCEC	chr19	38706095	Missense_Mutation	rs149027682	P179L	0.4
UCEC	chr19	38724506	Missense_Mutation	NA	R651C	0.3
UCEC	chr19	38727077	Missense_Mutation	NA	R771W	0.35
UCEC	chr19	38729310	Frame_Shift_Del	NA	*D874Tfs44**	0.67
UCEC	chr19	38729310	Frame_Shift_Del	NA	*D874Tfs44**	0.28
UCEC	chr19	38709427	Silent	rs763760070	F228F	0.36
UCEC	chr19	38724050	Missense_Mutation	NA	F555L	0.38
UCEC	chr19	38704996	Missense_Mutation	novel	A154T	0.51
UCEC	chr19	38708127	Missense_Mutation	novel	G195C	0.37
UCEC	chr19	38727081	Missense_Mutation	rs760946329	A772V	0.29
UCEC	chr19	38730544	3'UTR	rs753250986		0.1
UCEC	chr19	38718059	Missense_Mutation	rs752949932	E426K	0.13
UCEC	chr19	38724065	Silent	rs200269395	I560I	0.45
UCEC	chr19	38701108	Silent	NA	S128S	0.07
UCEC	chr19	38730431	3'UTR	novel		0.48
UCEC	chr19	38724075	Missense_Mutation	NA	E564K	0.41
UCEC	chr19	38730431	3'UTR	novel		0.54
UCEC	chr19	38724307	Missense_Mutation	NA	T615A	0.31
UCEC	chr19	38729310	Frame_Shift_Del	NA	*D874Tfs44**	0.61
UCEC	chr19	38709449	Missense_Mutation	NA	D236N	0.53
UCEC	chr19	38730547	3'UTR	novel		0.48
UCEC	chr19	38701088	Missense_Mutation	novel	K122E	0.36
UCEC	chr19	38721717	Intron	novel		0.29
UCEC	chr19	38724491	Missense_Mutation	novel	S646T	0.2
UCEC	chr19	38730431	3'UTR	novel		0.6
UCEC	chr19	38709476	Missense_Mutation	novel	D245Y	0.33
UCEC	chr19	38700630	Missense_Mutation	NA	R65W	0.44
UCEC	chr19	38730431	3'UTR	novel		0.42
UCEC	chr19	38717104	Missense_Mutation	novel	R311C	0.17
UCEC	chr19	38727097	Silent	rs539072997	F777F	0.18
UCEC	chr19	38730637	3'UTR	novel		0.28
UCEC	chr19	38728017	Silent	rs767454781	N803N	0.45
UCEC	chr19	38730431	3'UTR	novel		0.51
UCEC	chr19	38700618	Missense_Mutation	novel	N61H	0.44
UCEC	chr19	38730431	3'UTR	novel		0.49
UCEC	chr19	38721665	Silent	rs746743503	I473I	0.32
UCEC	chr19	38730466	3'UTR	novel		0.35
UCEC	chr19	38730431	3'UTR	novel		0.4
UCEC	chr19	38730431	3'UTR	novel		0.4
UCEC	chr19	38730431	3'UTR	novel		0.37
UCEC	chr19	38718003	Missense_Mutation	novel	R407M	0.41
UCEC	chr19	38730431	3'UTR	novel		0.43
UCEC	chr19	38723971	Missense_Mutation	NA	L529P	0.25
UCEC	chr19	38730431	3'UTR	novel		0.51
UCEC	chr19	38704996	Missense_Mutation	novel	A154T	0.46
UCEC	chr19	38714488	Missense_Mutation	novel	R280Q	0.28
UCEC	chr19	38727077	Missense_Mutation	NA	R771W	0.21
UCEC	chr19	38709428	Missense_Mutation	novel	E229K	0.55
UCEC	chr19	38721638	Silent	novel	A464A	0.39
UCEC	chr19	38730431	3'UTR	novel		0.34
UCEC	chr19	38729310	Frame_Shift_Del	NA	*D874Tfs44**	0.42
UCEC	chr19	38714554	Missense_Mutation	novel	A302V	0.29
UCEC	chr19	38717230	Silent	novel	L353L	0.41
UCEC	chr19	38729347	Missense_Mutation	rs767861850	A884V	0.45
UCEC	chr19	38730277	3'UTR	novel		0.45
UCS	chr19	38708155	Missense_Mutation	rs771095541	R204Q	0.31

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
KIRP	DEL	0.0451	0.054726
LUSC	AMP	0.3693	5.9091e-25
READ	DEL	0.0606	0.23023
UCS	DEL	0.125	0.12448

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.0001	Kaplan-Meier Survival Analysis
MESO	0.00016	Kaplan-Meier Survival Analysis
ACC	0.044	Kaplan-Meier Survival Analysis
HNSC	0.045	Kaplan-Meier Survival Analysis
SKCM	0.0033	Kaplan-Meier Survival Analysis
ESCA	0.046	Kaplan-Meier Survival Analysis
COAD	0.046	Kaplan-Meier Survival Analysis
PAAD	0.00092	Kaplan-Meier Survival Analysis
LAML	0.00028	Kaplan-Meier Survival Analysis
UCEC	0.0061	Kaplan-Meier Survival Analysis
LIHC	0.017	Kaplan-Meier Survival Analysis
THCA	0.02	Kaplan-Meier Survival Analysis
LUAD	0.0056	Kaplan-Meier Survival Analysis
OV	0.027	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000130402 (Gene tree)
Gene ID: 81
Gene Symbol: ACTN4
Alias: FSGS1
Full Name: actinin alpha 4
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 83,968 bases
Position: chr19:38,647,616-38,731,583
Accession: 166
RBP type: non-canonical RBP
Summary: Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, alpha actinin isoform which is concentrated in the cytoplasm, and thought to be involved in metastatic processes. Mutations in this gene have been associated with focal and segmental glomerulosclerosis. [provided by RefSeq, Jul 2008]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
28216224	Targeted proteomics driven verification of biomarker candidates associated with breast cancer aggressiveness.	Biochim Biophys Acta Proteins Proteom	2017 May	Prochazkova I	doi: 10.1016/j.bbapap.2017.02.012
28533408	RNA editing of SLC22A3 drives early tumor invasion and metastasis in familial esophageal cancer.	Proc Natl Acad Sci U S A	2017 Jun 6	Fu L	doi: 10.1073/pnas.1703178114

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000252699	ACTN4-201	4963	XM_005259281	ENSP00000252699	911 (aa)	XP_005259338	O43707
ENST00000497637	ACTN4-208	877	-	-	- (aa)	-	-
ENST00000589528	ACTN4-211	441	-	ENSP00000467190	105 (aa)	-	K7EP19
ENST00000390009	ACTN4-202	2102	-	ENSP00000439497	692 (aa)	-	O43707
ENST00000586538	ACTN4-209	546	-	ENSP00000465176	182 (aa)	-	K7EJH8
ENST00000495553	ACTN4-207	586	-	-	- (aa)	-	-
ENST00000588618	ACTN4-210	1729	-	-	- (aa)	-	-
ENST00000424234	ACTN4-203	1566	-	ENSP00000411187	521 (aa)	-	F5GXS2
ENST00000477174	ACTN4-205	544	-	-	- (aa)	-	-
ENST00000489451	ACTN4-206	654	-	-	- (aa)	-	-
ENST00000440400	ACTN4-204	3180	-	ENSP00000398393	342 (aa)	-	H7C144

Gene Model

Click here to download ENSG00000130402's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa04510	Focal adhesion	KEGG
hsa04520	Adherens junction	KEGG
hsa04530	Tight junction	KEGG
hsa04670	Leukocyte transendothelial migration	KEGG
hsa04810	Regulation of actin cytoskeleton	KEGG
hsa05146	Amoebiasis	KEGG
hsa05203	Viral carcinogenesis	KEGG
hsa05322	Systemic lupus erythematosus	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000130402	Liver Cirrhosis, Biliary	7.0740000E-006	20639880
ENSG00000130402	Heart Rate	2E-6	23583979
ENSG00000130402	Migraine Disorders	4E-6	23793025

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000130402	rs11083475	19	38697472	G	Heart rate	23583979			EFO_0004326
ENSG00000130402	rs973009	19	38683692	?	Migraine with aura	23793025	[1.1-1.27]	1.18	EFO_0003821

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000130402's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000130402	ACTN4	100	98.901	ENSMUSG00000054808	Actn4	100	100.000	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding	25411248.	IDA	Function
GO:0001666	response to hypoxia	-	IEA	Process
GO:0001725	stress fiber	-	IEA	Component
GO:0001882	nucleoside binding	12411747.	IDA	Function
GO:0002576	platelet degranulation	-	TAS	Process
GO:0003713	transcription coactivator activity	25411248.	IMP	Function
GO:0003723	RNA binding	22658674.	HDA	Function
GO:0003779	actin binding	8104223.	TAS	Function
GO:0005178	integrin binding	8104223.	TAS	Function
GO:0005509	calcium ion binding	-	IEA	Function
GO:0005515	protein binding	15619032.15841212.15988023.16189514.16204054.16944923.19447967.22351778.22662192.24802111.25241761.25411248.25416956.25910212.26496610.26871637.	IPI	Function
GO:0005576	extracellular region	-	TAS	Component
GO:0005615	extracellular space	16502470.	HDA	Component
GO:0005634	nucleus	9508771.22351778.25411248.	IDA	Component
GO:0005737	cytoplasm	16791210.	HDA	Component
GO:0005737	cytoplasm	9508771.22351778.25411248.	IDA	Component
GO:0005829	cytosol	-	IDA	Component
GO:0005903	brush border	-	IEA	Component
GO:0005911	cell-cell junction	-	IEA	Component
GO:0005925	focal adhesion	21423176.	HDA	Component
GO:0015031	protein transport	-	IEA	Process
GO:0015629	actin cytoskeleton	25918384.	IDA	Component
GO:0016604	nuclear body	-	IDA	Component
GO:0030018	Z disc	-	IEA	Component
GO:0030050	vesicle transport along actin filament	25918384.	IMP	Process
GO:0030335	positive regulation of cell migration	25918384.	IMP	Process
GO:0030374	nuclear receptor transcription coactivator activity	22351778.	IMP	Function
GO:0030863	cortical cytoskeleton	-	IEA	Component
GO:0031093	platelet alpha granule lumen	-	TAS	Component
GO:0031143	pseudopodium	1629252.	TAS	Component
GO:0031490	chromatin DNA binding	25411248.	IDA	Function
GO:0032417	positive regulation of sodium:proton antiporter activity	11948184.	NAS	Process
GO:0032991	protein-containing complex	11948184.	IDA	Component
GO:0033209	tumor necrosis factor-mediated signaling pathway	25411248.	IDA	Process
GO:0035257	nuclear hormone receptor binding	22351778.	IPI	Function
GO:0035357	peroxisome proliferator activated receptor signaling pathway	22351778.	IDA	Process
GO:0042803	protein homodimerization activity	22351778.	IPI	Function
GO:0042803	protein homodimerization activity	15841212.	TAS	Function
GO:0042974	retinoic acid receptor binding	22351778.	IPI	Function
GO:0042981	regulation of apoptotic process	16807302.	NAS	Process
GO:0043005	neuron projection	-	IEA	Component
GO:0044325	ion channel binding	19943616.	IPI	Function
GO:0047485	protein N-terminus binding	-	IEA	Function
GO:0048384	retinoic acid receptor signaling pathway	22351778.	IDA	Process
GO:0048471	perinuclear region of cytoplasm	15619032.	IDA	Component
GO:0048549	positive regulation of pinocytosis	-	IEA	Process
GO:0051015	actin filament binding	12411747.	IDA	Function
GO:0051015	actin filament binding	25918384.	IMP	Function
GO:0051017	actin filament bundle assembly	-	IEA	Process
GO:0051271	negative regulation of cellular component movement	-	IEA	Process
GO:0051272	positive regulation of cellular component movement	9508771.	IDA	Process
GO:0051272	positive regulation of cellular component movement	15048094.	IMP	Process
GO:0070062	extracellular exosome	19199708.20458337.21362503.23533145.	HDA	Component
GO:0070830	bicellular tight junction assembly	-	IEA	Process
GO:1900025	negative regulation of substrate adhesion-dependent cell spreading	25918384.	IMP	Process
GO:1901224	positive regulation of NIK/NF-kappaB signaling	25411248.	IMP	Process
GO:1902396	protein localization to bicellular tight junction	-	IEA	Process
GO:1903506	regulation of nucleic acid-templated transcription	22351778.	IMP	Process
GO:1903508	positive regulation of nucleic acid-templated transcription	-	IEA	Process
GO:1990904	ribonucleoprotein complex	17289661.	IDA	Component

EuRBPDB

Note: to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.