EuRBPDB

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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
27121206Efficacy of adjuvant chemotherapy for non-small cell lung cancer assessed by metastatic potential associated with ACTN4.Oncotarget2016 May 31Miura Ndoi: 10.18632/oncotarget.8890.
19151661Actinin-4 gene amplification in ovarian cancer: a candidate oncogene associated with poor patient prognosis and tumor chemoresistance.Mod Pathol2009 AprYamamoto Sdoi: 10.1038/modpathol.2008.234
15493875Non-muscle alpha-actinin-4 interacts with plasminogen activator inhibitor type-1 (PAI-1).Biol Chem2004 SepMagdolen U-
21408150HAMLET binding to α-actinin facilitates tumor cell detachment.PLoS One2011 Mar 8Trulsson Mdoi: 10.1371/journal.pone.0017179.
27065319α-Actinin-4 induces the epithelial-to-mesenchymal transition and tumorigenesis via regulation of Snail expression and β-catenin stabilization in cervical cancer.Oncogene2016 Nov 10An HTdoi: 10.1038/onc.2016.117
28385383Prognostic significance of gene amplification of ACTN4 in stage I and II oral tongue cancer.Int J Oral Maxillofac Surg2017 AugKakuya Tdoi: 10.1016/j.ijom.2017.03.001
29921500Measurement of copy number of ACTN4 to optimize the therapeutic strategy for locally advanced pancreatic cancer.Pancreatology2018 SepShoji Hdoi: 10.1016/j.pan.2018.06.003
25299231Alpha-actinin 4 is associated with cancer cell motility and is a potential biomarker in non-small cell lung cancer.J Thorac Oncol2015 FebWang MCdoi: 10.1097/JTO.0000000000000396.
25216292Estrogen stimulates the invasion of ovarian cancer cells via activation of the PI3K/AKT pathway and regulation of its downstream targets Ecadherin and αactinin4.Mol Med Rep2014 NovLu Zdoi: 10.3892/mmr.2014.2561
21078666The actin-binding protein, actinin alpha 4 (ACTN4), is a nuclear receptor coactivator that promotes proliferation of MCF-7 breast cancer cells.J Biol Chem2011 Jan 21Khurana Sdoi: 10.1074/jbc.M110.162107
19913389RNAi-mediated down-regulation of alpha-actinin-4 decreases invasion potential in oral squamous cell carcinoma.Int J Oral Maxillofac Surg2010 JanYamada Sdoi: 10.1016/j.ijom.2009.10.003
23810014Alpha-actinin 4 and tumorigenesis of breast cancer.Vitam Horm2013Hsu KSdoi: 10.1016/B978-0-12-416673-8.00005-8.
25885339ACTN4 and the pathways associated with cell motility and adhesion contribute to the process of lung cancer metastasis to the brain.BMC Cancer2015 Apr 12Gao Ydoi: 10.1186/s12885-015-1295-9.
23817592Increased expression of α-actinin-4 is associated with unfavorable pathological features and invasiveness of bladder cancer.Oncol Rep2013 SepYoshii Hdoi: 10.3892/or.2013.2577
25602965ACTN4 copy number increase as a predictive biomarker for chemoradiotherapy of locally advanced pancreatic cancer.Br J Cancer2015 Feb 17Watanabe Tdoi: 10.1038/bjc.2014.623
24922688Histological growth pattern of and alpha-actinin-4 expression in thyroid cancer.Anticancer Res2014 JunTanaka N-
29055790α-Actinin-4 confers radioresistance coupled invasiveness in breast cancer cells through AKT pathway.Biochim Biophys Acta Mol Cell Res2018 JanDesai Sdoi: 10.1016/j.bbamcr.2017.10.006

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
BLCAchr1938724175Missense_MutationnovelD571Y0.19
BLCAchr1938727949Missense_MutationnovelH781Y0.24
BLCAchr1938717989SilentNAL402L0.24
BLCAchr1938725726Missense_MutationnovelE671D0.15
BLCAchr1938729289Missense_MutationnovelE865Q0.39
BLCAchr1938729377Missense_MutationNAG894D0.2
BLCAchr1938701111Silentrs550083317I129I0.34
BLCAchr1938729129Missense_MutationNAS851F0.11
BLCAchr1938729401Missense_MutationnovelS902C0.25
BLCAchr1938721651Missense_Mutationrs752441330R469C0.32
BLCAchr1938709449Missense_MutationNAD236N0.17
BRCAchr1938729061Frame_Shift_DelNAQ829Kfs*270.33
BRCAchr1938723686Silentrs147922933L505L0.2
BRCAchr1938700667Missense_MutationnovelD77G0.19
BRCAchr1938717152Missense_MutationNAE327K0.42
BRCAchr1938723677Missense_MutationnovelW502C0.18
BRCAchr19387297863'UTRnovel0.4
BRCAchr1938727040Silentrs767071822D758D0.11
BRCAchr1938725874Missense_MutationNAD721Y0.2
BRCAchr1938717993Missense_MutationnovelE404Q0.21
BRCAchr19387304833'UTRnovel0.04
BRCAchr1938727011Missense_MutationnovelE749K0.12
BRCAchr1938706095Missense_MutationNAP179R0.28
BRCAchr1938717266Missense_Mutationrs752211925R365C0.3
CESCchr1938729070SilentNAF831F0.52
CESCchr19387305443'UTRnovel0.42
CESCchr19387306773'UTRnovel0.52
CESCchr1938726975Missense_MutationNAE737K0.22
CESCchr1938718071Missense_MutationnovelD430N0.18
CESCchr1938729065Missense_MutationnovelA830T0.09
CESCchr1938729066Missense_MutationnovelA830V0.08
CESCchr1938729055SilentNAV826V0.19
CESCchr1938729289Nonsense_MutationNAE865*0.11
CESCchr1938701068Missense_MutationnovelA115V0.46
CESCchr1938723629Silentrs372458891Y486Y0.43
CESCchr1938729336Silentrs565687082I880I0.29
CESCchr1938710283Missense_MutationnovelE254K0.23
COADchr1938708147SilentNAL201L0.15
COADchr1938724024Missense_Mutationrs762475438A547T0.38
COADchr1938729097Silentrs372396071T840T0.1
COADchr1938724017Missense_MutationnovelM544I0.06
COADchr1938729087Missense_Mutationrs368563044R837Q0.41
COADchr1938729337Missense_Mutationrs148628123A881T0.26
COADchr1938729084Missense_Mutationrs766882748S836L0.33
COADchr1938724510Missense_MutationnovelR652H0.32
COADchr1938724043Missense_MutationnovelD553G0.07
COADchr1938700677SilentNAD80D0.28
COADchr1938725863Missense_MutationnovelA717V0.11
COADchr1938704945Missense_Mutationrs375921941G137S0.32
COADchr1938714562Splice_SiteNAX304_splice0.15
COADchr1938701121Nonsense_MutationnovelE133*0.38
COADchr1938728008Silentrs138139611D800D0.14
COADchr1938701007Missense_Mutationrs771850037R95W0.17
ESCAchr1938718000Missense_MutationnovelR406H0.17
ESCAchr19387305483'UTRnovel0.26
ESCAchr1938718043SilentnovelQ420Q0.28
ESCAchr19387308193'UTRnovel0.18
ESCAchr1938708154Missense_MutationnovelR204W0.22
GBMchr1938729103Silentrs375763862T842T0.36
GBMchr1938729337Missense_Mutationrs148628123A881T0.24
GBMchr1938725796Missense_Mutationrs769829818R695C0.72
GBMchr1938729010SilentNAF811F0.34
GBMchr1938717180Missense_MutationnovelR336H0.25
GBMchr1938723712Missense_MutationnovelE514V0.19
GBMchr1938714543Silentrs568574676Y298Y0.12
HNSCchr1938723717Missense_MutationnovelL516M0.38
HNSCchr1938724452Missense_MutationnovelR633W0.17
HNSCchr1938729091Missense_MutationnovelE838D0.09
HNSCchr1938701101Missense_MutationnovelL126Q0.29
HNSCchr1938724281Missense_Mutationrs747590691S606L0.31
KICHchr1938726990Missense_MutationnovelT742A0.37
KIRCchr1938725723Splice_SiteNAX671_splice0.42
KIRCchr1938714538Missense_MutationNAD297N0.06
KIRCchr1938724197Missense_MutationNAP578L0.31
KIRCchr1938729309Frame_Shift_InsnovelD874Rfs*170.4
KIRPchr1938724026SilentnovelA547A0.33
KIRPchr19387294613'UTRrs7736336200.44
KIRPchr1938729051Missense_MutationnovelL825P0.46
LGGchr1938721640Missense_Mutationrs753703237A465V0.24
LGGchr1938724061Missense_MutationnovelT559N0.41
LIHCchr1938717205Silentrs753535029P344P0.08
LUADchr1938721668Silentrs149647148A474A0.08
LUADchr1938723952SilentNAL523L0.45
LUADchr1938717152Missense_MutationNAE327K0.23
LUADchr1938724214Missense_Mutationrs376144793R584C0.07
LUADchr1938729376Missense_Mutationrs141002044G894S0.14
LUADchr1938729309Frame_Shift_InsnovelD874Rfs*170.27
LUADchr1938647825Missense_MutationnovelS27I0.67
LUADchr1938717235Missense_MutationnovelE354D0.43
LUADchr1938729044Missense_MutationNAS823C0.57
LUADchr1938710270SilentnovelT249T0.18
LUSCchr1938723705Missense_MutationNAR512G0.28
LUSCchr1938717170Nonsense_MutationNAE333*0.42
LUSCchr1938710342Splice_RegionnovelK273K0.4
LUSCchr1938724517SilentnovelF654F0.4
LUSCchr1938724429Splice_SitenovelX626_splice0.19
LUSCchr1938724555Missense_MutationNAT667N0.26
LUSCchr19387294603'UTRrs7726124100.19
LUSCchr1938725840Missense_MutationnovelQ709H0.35
LUSCchr1938706066SilentNAL169L0.14
LUSCchr1938706067Missense_MutationNAL170F0.14
LUSCchr1938700625Missense_MutationnovelH63L0.29
LUSCchr1938721646Missense_MutationNAQ467R0.22
LUSCchr1938717092Nonsense_MutationnovelE307*0.17
LUSCchr1938718051Missense_MutationnovelS423C0.41
LUSCchr1938724217Missense_Mutationrs759789993E585K0.24
MESOchr1938723705Missense_Mutationrs778312331R512C0.1
OVchr1938725745Missense_MutationnovelE678K0.22
OVchr1938724238Missense_MutationnovelK592E0.16
OVchr1938717290Frame_Shift_InsnovelM373Tfs*310.33
PRADchr1938700607Missense_Mutationrs768656011T57M0.35
PRADchr1938717128Missense_MutationnovelR319C0.38
PRADchr1938728017Silentrs767454781N803N0.39
PRADchr1938729368Missense_MutationnovelA891V0.38
READchr1938721629Silentrs750702920S461S0.35
READchr1938724050Missense_MutationNAF555L0.38
READchr1938708147SilentNAL201L0.44
READchr1938706108SilentnovelV183V0.12
SARCchr1938724191Missense_MutationnovelT576I0.38
SARCchr19387305343'UTRnovel0.44
SARCchr1938704998SilentnovelA154A0.46
SARCchr1938723936Splice_SitenovelX518_splice0.26
SARCchr1938724075Missense_MutationnovelE564Q0.34
SARCchr1938710275Missense_Mutationrs561181666R251Q0.26
SARCchr1938721757Intronnovel0.83
SKCMchr1938724551Nonsense_MutationNAQ666*0.35
SKCMchr1938721704Intronnovel0.28
SKCMchr1938729129Missense_MutationNAS851F0.19
SKCMchr1938724466SilentnovelL637L0.45
SKCMchr1938700699SilentnovelL88L0.48
SKCMchr1938717114Missense_MutationNAP314L0.4
SKCMchr1938721689Splice_SiteNAX481_splice0.26
SKCMchr1938700672Nonsense_MutationNAR79*0.16
SKCMchr1938724235Missense_MutationNAH591Y0.22
SKCMchr1938701108SilentnovelS128S0.48
STADchr1938717182Missense_MutationNAD337N0.1
STADchr1938729392Missense_MutationnovelK899R0.07
STADchr1938717301SilentNAE376E0.5
STADchr1938700673Missense_Mutationrs759055242R79Q0.35
STADchr1938717249Missense_MutationNAT359M0.32
STADchr1938724440SilentNAL629L0.14
STADchr1938729405Silentrs760996008T903T0.34
STADchr1938729310Frame_Shift_DelNAD874Tfs*440.35
STADchr1938717280SilentNAR369R0.12
STADchr1938727955Missense_Mutationrs778422858G783R0.31
STADchr1938723680Silentrs750084549D503D0.3
STADchr1938706112Missense_MutationnovelV185M0.17
STADchr1938727953Missense_MutationnovelG782D0.4
STADchr1938728013Missense_MutationNAE802A0.11
STADchr1938729125Missense_Mutationrs376869655A850T0.21
STADchr1938724197Missense_MutationNAP578L0.24
STADchr1938717191Missense_Mutationrs760523958R340C0.33
STADchr1938724303SilentNAT613T0.21
STADchr1938709427Silentrs763760070F228F0.46
STADchr1938723991Missense_Mutationrs372902386R536C0.48
UCECchr19387307153'UTRnovel0.38
UCECchr1938709427Silentrs763760070F228F0.33
UCECchr1938700631Missense_MutationnovelR65Q0.22
UCECchr1938709427Silentrs763760070F228F0.4
UCECchr1938717147Missense_MutationnovelI325S0.32
UCECchr1938709427Silentrs763760070F228F0.13
UCECchr19387304313'UTRnovel0.42
UCECchr1938729284Missense_MutationnovelT863I0.07
UCECchr19387304313'UTRnovel0.35
UCECchr1938709427Silentrs763760070F228F0.12
UCECchr1938710261Silentrs34491236I246I0.38
UCECchr1938714522Silentrs374240674N291N0.33
UCECchr1938723629Silentrs372458891Y486Y0.42
UCECchr1938717266Missense_Mutationrs752211925R365C0.41
UCECchr1938710261Silentrs34491236I246I0.18
UCECchr1938717249Missense_MutationNAT359M0.29
UCECchr1938721624Missense_Mutationrs767795519E460K0.27
UCECchr1938724249SilentNAQ595Q0.24
UCECchr1938724542Missense_MutationNAP663S0.29
UCECchr19387304313'UTRnovel0.52
UCECchr1938714480Silentrs773662358A277A0.34
UCECchr1938724255Silentrs780958051I597I0.32
UCECchr1938704979Missense_MutationNAT148I0.28
UCECchr1938717176Missense_MutationNAF335V0.19
UCECchr1938717134Frame_Shift_DelnovelQ322Kfs*810.41
UCECchr19387304313'UTRnovel0.53
UCECchr1938709428Missense_MutationnovelE229K0.2
UCECchr1938710319Missense_MutationnovelH266Y0.3
UCECchr1938729014Missense_Mutationrs755524840R813C0.28
UCECchr19387304313'UTRnovel0.94
UCECchr19387303143'UTRnovel0.17
UCECchr1938706095Missense_Mutationrs149027682P179L0.4
UCECchr1938724506Missense_MutationNAR651C0.3
UCECchr1938727077Missense_MutationNAR771W0.35
UCECchr1938729310Frame_Shift_DelNAD874Tfs*440.67
UCECchr1938729310Frame_Shift_DelNAD874Tfs*440.28
UCECchr1938709427Silentrs763760070F228F0.36
UCECchr1938724050Missense_MutationNAF555L0.38
UCECchr1938704996Missense_MutationnovelA154T0.51
UCECchr1938708127Missense_MutationnovelG195C0.37
UCECchr1938727081Missense_Mutationrs760946329A772V0.29
UCECchr19387305443'UTRrs7532509860.1
UCECchr1938718059Missense_Mutationrs752949932E426K0.13
UCECchr1938724065Silentrs200269395I560I0.45
UCECchr1938701108SilentNAS128S0.07
UCECchr19387304313'UTRnovel0.48
UCECchr1938724075Missense_MutationNAE564K0.41
UCECchr19387304313'UTRnovel0.54
UCECchr1938724307Missense_MutationNAT615A0.31
UCECchr1938729310Frame_Shift_DelNAD874Tfs*440.61
UCECchr1938709449Missense_MutationNAD236N0.53
UCECchr19387305473'UTRnovel0.48
UCECchr1938701088Missense_MutationnovelK122E0.36
UCECchr1938721717Intronnovel0.29
UCECchr1938724491Missense_MutationnovelS646T0.2
UCECchr19387304313'UTRnovel0.6
UCECchr1938709476Missense_MutationnovelD245Y0.33
UCECchr1938700630Missense_MutationNAR65W0.44
UCECchr19387304313'UTRnovel0.42
UCECchr1938717104Missense_MutationnovelR311C0.17
UCECchr1938727097Silentrs539072997F777F0.18
UCECchr19387306373'UTRnovel0.28
UCECchr1938728017Silentrs767454781N803N0.45
UCECchr19387304313'UTRnovel0.51
UCECchr1938700618Missense_MutationnovelN61H0.44
UCECchr19387304313'UTRnovel0.49
UCECchr1938721665Silentrs746743503I473I0.32
UCECchr19387304663'UTRnovel0.35
UCECchr19387304313'UTRnovel0.4
UCECchr19387304313'UTRnovel0.4
UCECchr19387304313'UTRnovel0.37
UCECchr1938718003Missense_MutationnovelR407M0.41
UCECchr19387304313'UTRnovel0.43
UCECchr1938723971Missense_MutationNAL529P0.25
UCECchr19387304313'UTRnovel0.51
UCECchr1938704996Missense_MutationnovelA154T0.46
UCECchr1938714488Missense_MutationnovelR280Q0.28
UCECchr1938727077Missense_MutationNAR771W0.21
UCECchr1938709428Missense_MutationnovelE229K0.55
UCECchr1938721638SilentnovelA464A0.39
UCECchr19387304313'UTRnovel0.34
UCECchr1938729310Frame_Shift_DelNAD874Tfs*440.42
UCECchr1938714554Missense_MutationnovelA302V0.29
UCECchr1938717230SilentnovelL353L0.41
UCECchr1938729347Missense_Mutationrs767861850A884V0.45
UCECchr19387302773'UTRnovel0.45
UCSchr1938708155Missense_Mutationrs771095541R204Q0.31

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
KIRPDEL0.04510.054726
LUSCAMP0.36935.9091e-25
READDEL0.06060.23023
UCSDEL0.1250.12448

Survival Analysis
CancerP-value Q-value
KIRC0.0001

Kaplan-Meier Survival Analysis

MESO0.00016

Kaplan-Meier Survival Analysis

ACC0.044

Kaplan-Meier Survival Analysis

HNSC0.045

Kaplan-Meier Survival Analysis

SKCM0.0033

Kaplan-Meier Survival Analysis

ESCA0.046

Kaplan-Meier Survival Analysis

COAD0.046

Kaplan-Meier Survival Analysis

PAAD0.00092

Kaplan-Meier Survival Analysis

LAML0.00028

Kaplan-Meier Survival Analysis

UCEC0.0061

Kaplan-Meier Survival Analysis

LIHC0.017

Kaplan-Meier Survival Analysis

THCA0.02

Kaplan-Meier Survival Analysis

LUAD0.0056

Kaplan-Meier Survival Analysis

OV0.027

Kaplan-Meier Survival Analysis

Drugs

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Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBPome
  • Literatures
  • Expression
  • Transcripts
  • Gene Model
  • Pathways
  • Phenotypes
  • GWAS
  • PPI
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000130402 (Gene tree)
Gene ID
81
Gene Symbol
ACTN4
Alias
FSGS1
Full Name
actinin alpha 4
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Plus strand
Length
83,968 bases
Position
chr19:38,647,616-38,731,583
Accession
166
RBP type
non-canonical RBP
Summary
Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, alpha actinin isoform which is concentrated in the cytoplasm, and thought to be involved in metastatic processes. Mutations in this gene have been associated with focal and segmental glomerulosclerosis. [provided by RefSeq, Jul 2008]
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & HEK2932019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & HEK2932018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
29431736Capturing the interactome of newly transcribed RNARICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
22658674Insights into RNA biology from an atlas of mammalian mRNA-binding proteinsRIC & Hela2012 May 31Castello ADOI: 10.1016/j.cell.2012.04.031
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & Hela2018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & MCF10A2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & MCF72018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & U2OS2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
28216224Targeted proteomics driven verification of biomarker candidates associated with breast cancer aggressiveness.Biochim Biophys Acta Proteins Proteom2017 MayProchazkova Idoi: 10.1016/j.bbapap.2017.02.012
28533408RNA editing of SLC22A3 drives early tumor invasion and metastasis in familial esophageal cancer.Proc Natl Acad Sci U S A2017 Jun 6Fu Ldoi: 10.1073/pnas.1703178114
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000252699ACTN4-2014963XM_005259281ENSP00000252699911 (aa)XP_005259338O43707
ENST00000497637ACTN4-208877--- (aa)--
ENST00000589528ACTN4-211441-ENSP00000467190105 (aa)-K7EP19
ENST00000390009ACTN4-2022102-ENSP00000439497692 (aa)-O43707
ENST00000586538ACTN4-209546-ENSP00000465176182 (aa)-K7EJH8
ENST00000495553ACTN4-207586--- (aa)--
ENST00000588618ACTN4-2101729--- (aa)--
ENST00000424234ACTN4-2031566-ENSP00000411187521 (aa)-F5GXS2
ENST00000477174ACTN4-205544--- (aa)--
ENST00000489451ACTN4-206654--- (aa)--
ENST00000440400ACTN4-2043180-ENSP00000398393342 (aa)-H7C144
Gene Model
Click here to download ENSG00000130402's gene model file
Pathways
Pathway IDPathway NameSource
hsa04510Focal adhesionKEGG
hsa04520Adherens junctionKEGG
hsa04530Tight junctionKEGG
hsa04670Leukocyte transendothelial migrationKEGG
hsa04810Regulation of actin cytoskeletonKEGG
hsa05146AmoebiasisKEGG
hsa05203Viral carcinogenesisKEGG
hsa05322Systemic lupus erythematosusKEGG
Phenotypes
ensgIDTraitpValuePubmed ID
ENSG00000130402Liver Cirrhosis, Biliary7.0740000E-00620639880
ENSG00000130402Heart Rate2E-623583979
ENSG00000130402Migraine Disorders4E-623793025
GWAS
ensgIDSNPChromosomePositionSNP-risk TraitPubmedID95% CIOr or BEAT EFO ID
ENSG00000130402rs110834751938697472GHeart rate23583979EFO_0004326
ENSG00000130402rs9730091938683692?Migraine with aura23793025[1.1-1.27]1.18EFO_0003821
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000130402's network

* RBP PPI network refers to all genes directly bind to RBP
Orthologs identified by RBPome
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000130402ACTN410098.901ENSMUSG00000054808Actn4100100.000Mus_musculus
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0000977RNA polymerase II regulatory region sequence-specific DNA binding25411248.IDAFunction
GO:0001666response to hypoxia-IEAProcess
GO:0001725stress fiber-IEAComponent
GO:0001882nucleoside binding12411747.IDAFunction
GO:0002576platelet degranulation-TASProcess
GO:0003713transcription coactivator activity25411248.IMPFunction
GO:0003723RNA binding22658674.HDAFunction
GO:0003779actin binding8104223.TASFunction
GO:0005178integrin binding8104223.TASFunction
GO:0005509calcium ion binding-IEAFunction
GO:0005515protein binding15619032.15841212.15988023.16189514.16204054.16944923.19447967.22351778.22662192.24802111.25241761.25411248.25416956.25910212.26496610.26871637.IPIFunction
GO:0005576extracellular region-TASComponent
GO:0005615extracellular space16502470.HDAComponent
GO:0005634nucleus9508771.22351778.25411248.IDAComponent
GO:0005737cytoplasm16791210.HDAComponent
GO:0005737cytoplasm9508771.22351778.25411248.IDAComponent
GO:0005829cytosol-IDAComponent
GO:0005903brush border-IEAComponent
GO:0005911cell-cell junction-IEAComponent
GO:0005925focal adhesion21423176.HDAComponent
GO:0015031protein transport-IEAProcess
GO:0015629actin cytoskeleton25918384.IDAComponent
GO:0016604nuclear body-IDAComponent
GO:0030018Z disc-IEAComponent
GO:0030050vesicle transport along actin filament25918384.IMPProcess
GO:0030335positive regulation of cell migration25918384.IMPProcess
GO:0030374nuclear receptor transcription coactivator activity22351778.IMPFunction
GO:0030863cortical cytoskeleton-IEAComponent
GO:0031093platelet alpha granule lumen-TASComponent
GO:0031143pseudopodium1629252.TASComponent
GO:0031490chromatin DNA binding25411248.IDAFunction
GO:0032417positive regulation of sodium:proton antiporter activity11948184.NASProcess
GO:0032991protein-containing complex11948184.IDAComponent
GO:0033209tumor necrosis factor-mediated signaling pathway25411248.IDAProcess
GO:0035257nuclear hormone receptor binding22351778.IPIFunction
GO:0035357peroxisome proliferator activated receptor signaling pathway22351778.IDAProcess
GO:0042803protein homodimerization activity22351778.IPIFunction
GO:0042803protein homodimerization activity15841212.TASFunction
GO:0042974retinoic acid receptor binding22351778.IPIFunction
GO:0042981regulation of apoptotic process16807302.NASProcess
GO:0043005neuron projection-IEAComponent
GO:0044325ion channel binding19943616.IPIFunction
GO:0047485protein N-terminus binding-IEAFunction
GO:0048384retinoic acid receptor signaling pathway22351778.IDAProcess
GO:0048471perinuclear region of cytoplasm15619032.IDAComponent
GO:0048549positive regulation of pinocytosis-IEAProcess
GO:0051015actin filament binding12411747.IDAFunction
GO:0051015actin filament binding25918384.IMPFunction
GO:0051017actin filament bundle assembly-IEAProcess
GO:0051271negative regulation of cellular component movement-IEAProcess
GO:0051272positive regulation of cellular component movement9508771.IDAProcess
GO:0051272positive regulation of cellular component movement15048094.IMPProcess
GO:0070062extracellular exosome19199708.20458337.21362503.23533145.HDAComponent
GO:0070830bicellular tight junction assembly-IEAProcess
GO:1900025negative regulation of substrate adhesion-dependent cell spreading25918384.IMPProcess
GO:1901224positive regulation of NIK/NF-kappaB signaling25411248.IMPProcess
GO:1902396protein localization to bicellular tight junction-IEAProcess
GO:1903506regulation of nucleic acid-templated transcription22351778.IMPProcess
GO:1903508positive regulation of nucleic acid-templated transcription-IEAProcess
GO:1990904ribonucleoprotein complex17289661.IDAComponent
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