EuRBPDB

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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
22948157Prolyl hydroxylase 3 (PHD3) modulates catabolic effects of tumor necrosis factor-α (TNF-α) on cells of the nucleus pulposus through co-activation of nuclear factor κB (NF-κB)/p65 signaling.J Biol Chem2012 Nov 16Fujita Ndoi: 10.1074/jbc.M112.375964
21748337The expression of prolyl hydroxylase domain enzymes are up-regulated and negatively correlated with Bcl-2 in non-small cell lung cancer.Mol Cell Biochem2011 DecChen Sdoi: 10.1007/s11010-011-0976-1
19786027Prolyl hydroxylase-3 is down-regulated in colorectal cancer cells and inhibits IKKbeta independent of hydroxylase activity.Gastroenterology2010 FebXue Jdoi: 10.1053/j.gastro.2009.09.049
28901473PHD3 affects gastric cancer progression by negatively regulating HIF1A.Mol Med Rep2017 NovXia YJdoi: 10.3892/mmr.2017.7455
21887331Overexpression of the HIF hydroxylases PHD1, PHD2, PHD3 and FIH are individually and collectively unfavorable prognosticators for NSCLC survival.PLoS One2011Andersen Sdoi: 10.1371/journal.pone.0023847
18927305Overexpression of the oxygen sensors PHD-1, PHD-2, PHD-3, and FIH Is associated with tumor aggressiveness in pancreatic endocrine tumors.Clin Cancer Res2008 Oct 15Couvelard Adoi: 10.1158/1078-0432.CCR-07-5258.
20028863Prolyl hydroxylases 2 and 3 act in gliomas as protective negative feedback regulators of hypoxia-inducible factors.Cancer Res2010 Jan 1Henze ATdoi: 10.1158/0008-5472.CAN-09-1876
28099905Prolyl hydroxylase domain protein 3 and asparaginyl hydroxylase factor inhibiting HIF-1 levels are predictive of tumoral behavior and prognosis in hepatocellular carcinoma.Oncotarget2017 Feb 21Ma Mdoi: 10.18632/oncotarget.14677.
22290580Overexpression of the HIF hydroxylase PHD3 is a favorable prognosticator for gastric cancer.Med Oncol2012 DecSu C-
25081707Expression of hypoxia-inducible factor prolyl hydroxylase 3 HIFPH3 in human non-small cell lung cancer (NSCLC) and its correlation with prognosis.Asian Pac J Cancer Prev2014Chu X-
23533015Prolyl hydroxylase 3 inhibited the tumorigenecity of gastric cancer cells.Mol Carcinog2014 SepCui Ldoi: 10.1002/mc.22025
21297970Aberrant promoter CpG methylation is a mechanism for impaired PHD3 expression in a diverse set of malignant cells.PLoS One2011 Jan 28Place TLdoi: 10.1371/journal.pone.0014617.
23601303[Advances of hypoxia and lung cancer].Zhongguo Fei Ai Za Zhi2013 AprLi Xdoi: 10.3779/j.issn.1009-3419.2013.04.08.
26372732Distinct breast cancer stem/progenitor cell populations require either HIF1α or loss of PHD3 to expand under hypoxic conditions.Oncotarget2015 Oct 13Iriondo Odoi: 10.18632/oncotarget.5564.
20727020DNA methylation analysis of the HIF-1α prolyl hydroxylase domain genes PHD1, PHD2, PHD3 and the factor inhibiting HIF gene FIH in invasive breast carcinomas.Histopathology2010 SepHuang KTdoi: 10.1111/j.1365-2559.2010.03633.x
25542265Increased expression of PHD3 represses the HIF-1 signaling pathway and contributes to poor neovascularization in pancreatic ductal adenocarcinoma.J Gastroenterol2015 SepTanaka Tdoi: 10.1007/s00535-014-1030-3
21620138Pyruvate kinase M2 is a PHD3-stimulated coactivator for hypoxia-inducible factor 1.Cell2011 May 27Luo Wdoi: 10.1016/j.cell.2011.03.054.
26921340Prolyl Hydroxylase 3 Attenuates MCL-1-Mediated ATP Production to Suppress the Metastatic Potential of Colorectal Cancer Cells.Cancer Res2016 Apr 15Radhakrishnan Pdoi: 10.1158/0008-5472.CAN-15-1474
27635760PHD3 Loss in Cancer Enables Metabolic Reliance on Fatty Acid Oxidation via Deactivation of ACC2.Mol Cell2016 Sep 15German NJdoi: 10.1016/j.molcel.2016.08.014.
29339541PHD3 Controls Lung Cancer Metastasis and Resistance to EGFR Inhibitors through TGFα.Cancer Res2018 Apr 1Dopeso Hdoi: 10.1158/0008-5472.CAN-17-1346
29688807Acetylation-mediated Siah2 stabilization enhances PHD3 degradation in Helicobacter pylori-infected gastric epithelial cancer cells.FASEB J2018 OctKokate SBdoi: 10.1096/fj.201701344RRR

Differential Expression

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
ACCchr1433950365Intronnovel0.65
BLCAchr1433950383Intronnovel0.11
BLCAchr14339508215'UTRNA0.14
BRCAchr1433950305Intronnovel0.2
BRCAchr14339507965'UTRrs7556929560.16
CESCchr1433931167Missense_MutationNAV136M0.1
CESCchr14339507965'UTRrs7556929560.35
CESCchr1433950612SilentnovelV47V0.29
CHOLchr14339257313'UTRnovel0.11
COADchr1433931193Missense_MutationNAG127E0.41
COADchr1433926999Missense_MutationnovelE217K0.07
COADchr1433929083Missense_Mutationrs375310922A203T0.27
COADchr1433950460Missense_MutationNAI98T0.122OG-FeII_Oxy
COADchr1433950672SilentnovelG27G0.17
COADchr14339258383'UTRnovel0.13
ESCAchr14339256873'UTRnovel0.3
GBMchr14339258563'UTRnovel0.05
GBMchr14339508075'UTRnovel0.14
HNSCchr14339508745'UTRnovel0.67
HNSCchr14339508215'UTRnovel0.14
HNSCchr1433950742Missense_MutationnovelG4E0.34
HNSCchr1433950372Intronnovel0.41
HNSCchr1433950711Missense_MutationnovelI14M0.35
KIRPchr14339508845'UTRnovel0.5
LGGchr1433950666Silentrs752377366C29C0.31
LUADchr1433950391Splice_Regionnovel0.51
LUADchr1433931188Nonsense_MutationnovelG129*0.15
LUADchr14339258703'UTRnovel0.48
LUADchr1433950705SilentNAL16L0.13
LUADchr1433927034Splice_SiteNAX205_splice0.12
LUADchr1433950494Missense_MutationnovelG87C0.252OG-FeII_Oxy
LUADchr1433950495Missense_MutationnovelE86D0.252OG-FeII_Oxy
LUADchr1433931152Missense_MutationnovelG141R0.28
LUADchr1433950738Silentrs61758135H5H0.21
LUADchr1433950594SilentNAT53T0.37
LUADchr1433931206Missense_MutationNAA123S0.21
LUADchr14339257523'UTRnovel0.6
LUADchr1433950432Missense_MutationnovelS107R0.182OG-FeII_Oxy
LUADchr1433929116Missense_MutationNAR192C0.09
LUSCchr1433929194Missense_Mutationrs749363666R166W0.58
LUSCchr14339258743'UTRnovel0.23
LUSCchr1433950450SilentNAL101L0.28
LUSCchr1433950451Missense_MutationNAL101P0.282OG-FeII_Oxy
LUSCchr14339508375'UTRnovel0.48
LUSCchr1433950580Missense_MutationNAD58V0.352OG-FeII_Oxy
LUSCchr14339508095'UTRnovel0.2
LUSCchr1433931153Missense_MutationnovelN140K0.32
LUSCchr1433931171SilentNAR134R0.25
LUSCchr1433950556Missense_MutationnovelA66V0.312OG-FeII_Oxy
OVchr14339508615'UTRnovel0.18
PAADchr1433950624SilentnovelV43V0.15
PRADchr1433950220Intronnovel0.38
PRADchr1433950492SilentnovelG87G0.24
SKCMchr14339258623'UTRnovel0.14
SKCMchr1433950651SilentNAF34F0.4
SKCMchr1433929151Missense_MutationnovelP180L0.32
SKCMchr1433950581Missense_MutationNAD58N0.472OG-FeII_Oxy
SKCMchr1433929180SilentNAE170E0.21
STADchr14339508215'UTRNA0.21
STADchr1433931123Silentrs762316505Y150Y0.05
THYMchr1433931201SilentnovelC124C0.11
UCECchr1433929101Missense_MutationNAE197K0.37
UCECchr14339256363'UTRrs5537157700.18
UCECchr1433950244Intronnovel0.38
UCECchr14339507855'UTRrs7670456450.48
UCECchr1433950673Missense_MutationnovelG27D0.222OG-FeII_Oxy
UCECchr14339255183'UTRnovel0.27
UCECchr1433950717Missense_MutationnovelE12D0.24
UCECchr1433950489SilentNAC88C0.36
UCECchr14339255183'UTRnovel0.15
UCECchr1433931176Missense_MutationnovelV133I0.26
UCECchr1433931197Missense_MutationnovelP126S0.29
UCECchr1433929116Missense_MutationNAR192C0.43
UCECchr14339258493'UTRnovel0.36
UCECchr1433950245Intronnovel0.39
UCECchr1433929101Missense_MutationNAE197K0.38
UCECchr1433929176Missense_MutationnovelK172E0.55
UCECchr14339258283'UTRnovel0.08
UCECchr1433926979Missense_MutationNAK223N0.16
UCECchr1433929122Missense_MutationNAS190T0.36
UCECchr1433926979Missense_MutationNAK223N0.4
UCECchr14339254473'UTRnovel0.33
UCECchr1433931148Missense_MutationnovelD142G0.37
UCECchr1433950263Intronnovel0.36
UCECchr1433950669Missense_MutationnovelF28L0.642OG-FeII_Oxy

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
ACCDEL0.17780.19769
CHOLDEL0.36110.00040262
KIRPDEL0.17360.085174
PAADDEL0.06520.11332

Survival Analysis
CancerP-value Q-value
THYM0.014

Kaplan-Meier Survival Analysis

KIRC0.0078

Kaplan-Meier Survival Analysis

MESO0.0039

Kaplan-Meier Survival Analysis

HNSC0.049

Kaplan-Meier Survival Analysis

SKCM0.0013

Kaplan-Meier Survival Analysis

PAAD0.045

Kaplan-Meier Survival Analysis

CESC0.0081

Kaplan-Meier Survival Analysis

KICH0.034

Kaplan-Meier Survival Analysis

UCEC0.05

Kaplan-Meier Survival Analysis

LIHC0.0001

Kaplan-Meier Survival Analysis

DLBC0.01

Kaplan-Meier Survival Analysis

LGG0.0073

Kaplan-Meier Survival Analysis

LUAD0.00059

Kaplan-Meier Survival Analysis

UVM0.0017

Kaplan-Meier Survival Analysis

Drugs

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Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBDs
  • Literatures
  • Expression
  • Transcripts
  • Gene Model
  • Pathways
  • Phenotypes
  • GWAS
  • PPI
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000129521 (Gene tree)
Gene ID
112399
Gene Symbol
EGLN3
Alias
PHD3|HIFPH3
Full Name
egl-9 family hypoxia inducible factor 3
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Minus strand
Length
538,560 bases
Position
chr14:33,924,215-34,462,774
Accession
14661
RBP type
canonical RBP
Summary
EGLN3 (Egl-9 Family Hypoxia Inducible Factor 3) is a Protein Coding gene. Diseases associated with EGLN3 include Hypoxia and Chronic Mountain Sickness. Among its related pathways are CDK-mediated phosphorylation and removal of Cdc6 and HIF Repressor Pathways. Gene Ontology (GO) annotations related to this gene include oxidoreductase activity and oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen. An important paralog of this gene is EGLN1.
RNA binding domains(RBDs)
Protein IDDomain Pfam IDE-value Domain number Total number
ENSP000004474702OG-FeII_OxyPF03171.201.5e-0511

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
20460131Molecular mechanism of MLL PHD3 and RNA recognition by the Cyp33 RRM domain.J Mol Biol2010 Jul 9Hom RAdoi: 10.1016/j.jmb.2010.04.067
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000546681EGLN3-204581--- (aa)--
ENST00000551935EGLN3-208575--- (aa)--
ENST00000553215EGLN3-2091004-ENSP00000447470145 (aa)-F8W1G2
ENST00000487915EGLN3-203848-ENSP0000045131679 (aa)-G3V3M1
ENST00000547327EGLN3-2052849-ENSP00000446572148 (aa)-F8VR39
ENST00000556785EGLN3-210864--- (aa)--
ENST00000250457EGLN3-2012709-ENSP00000250457239 (aa)-Q9H6Z9
ENST00000550114EGLN3-207566--- (aa)--
ENST00000557521EGLN3-211658--- (aa)--
ENST00000464521EGLN3-202352--- (aa)--
ENST00000548285EGLN3-206535--- (aa)--
Gene Model
Click here to download ENSG00000129521's gene model file
Pathways
Pathway IDPathway NameSource
hsa04066HIF-1 signaling pathwayKEGG
hsa05200Pathways in cancerKEGG
hsa05211Renal cell carcinomaKEGG
Phenotypes
ensgIDTraitpValuePubmed ID
ENSG00000129521Fibrinogen5.07816651189167E-517903294
ENSG00000129521Fibrinogen2.38174494351447E-617903294
ENSG00000129521Varicose Veins8.3543782868123E-5-
ENSG00000129521Osteoporosis6.49678632189676E-517903295
ENSG00000129521Mental Competency1.84886412635623E-617903295
ENSG00000129521Stroke5.5631319E-00519369658
ENSG00000129521Neuroblastoma1.71e-00523222812
ENSG00000129521Waist-Hip Ratio4.4450000E-006-
ENSG00000129521Waist-Hip Ratio1.0540000E-005-
ENSG00000129521Basophils4.4380000E-005-
ENSG00000129521Platelet Function Tests1.1900000E-007-
ENSG00000129521Platelet Function Tests4.7000000E-007-
ENSG00000129521Child Development Disorders, Pervasive6.5441600E-005-
ENSG00000129521Child Development Disorders, Pervasive1.4527000E-005-
ENSG00000129521Child Development Disorders, Pervasive6.0145500E-005-
ENSG00000129521Child Development Disorders, Pervasive1.0189500E-005-
ENSG00000129521alpha-carotene4.5640000E-006-
ENSG00000129521alpha-carotene2.8980000E-006-
ENSG00000129521Taste Perception3.2450000E-005-
ENSG00000129521Age-Related Hearing Impairment 18E-624939585
ENSG000001295213-hydroxy-1-methylpropylmercapturic acid3E-626053186
ENSG00000129521Smoking3E-626053186
ENSG00000129521Rest8E-727126917
ENSG00000129521Celiac Disease4E-623936387
GWAS
ensgIDSNPChromosomePositionSNP-risk TraitPubmedID95% CIOr or BEAT EFO ID
ENSG00000129521rs19585811434332393?Age-related hearing impairment24939585[NR] unit decrease0.1353EFO_0005782
ENSG00000129521rs575744931434149063GDaytime sleep phenotypes27126917[0.4-0.98] unit increase0.6878EFO_0007828
ENSG00000129521rs7973241434136247CDaytime sleep phenotypes27126917[0.34-0.79] unit increase0.5679EFO_0007828
ENSG00000129521rs19585891434375170CCeliac disease23936387EFO_0001060
ENSG00000129521rs1919369031434027246?3-hydroxy-1-methylpropylmercapturic acid levels in smokers26053186[NR] unit decrease1.1003EFO_0004318|EFO_0007015
ENSG00000129521rs101426351434423401AHeart rate response to beta blockers (atenolol add-on therapy)29478026[4.16-9.06] bpm decrease6.61EFO_0007766|EFO_0004326
ENSG00000129521rs768270351434324633GEotaxin levels27989323[0.1-0.255] SD units increase0.1776EFO_0008122
ENSG00000129521rs7973431434177063THematocrit27863252[0.015-0.03] unit increase0.02249192EFO_0004348
ENSG00000129521rs128796261434251928TIntraocular pressure29785010[0.054-0.104] unit increase0.079EFO_0004695
ENSG00000129521rs744127651434053698TReasoning29907492[NR] unit decrease1.7EFO_0004350
ENSG00000129521rs7973431434177063?Red blood cell count30595370EFO_0004305
ENSG00000129521rs358334681433974720?Alzheimer's disease (late onset)30820047[1.04-1.12]1.0869565EFO_1001870
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000129521's network

* RBP PPI network refers to all genes directly bind to RBP
Orthologs
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000129521EGLN39983.333ENSAPOG00000007757egln39964.502Acanthochromis_polyacanthus
ENSG00000129521EGLN39980.769ENSAOCG00000023534egln39962.338Amphiprion_ocellaris
ENSG00000129521EGLN39779.221ENSAOCG00000000273-9875.424Amphiprion_ocellaris
ENSG00000129521EGLN39779.221ENSAOCG00000019598-9876.271Amphiprion_ocellaris
ENSG00000129521EGLN39980.769ENSAPEG00000013864egln310061.181Amphiprion_percula
ENSG00000129521EGLN39983.333ENSAPEG00000000070-10062.393Amphiprion_percula
ENSG00000129521EGLN39984.615ENSATEG00000016315egln38583.810Anabas_testudineus
ENSG00000129521EGLN397100.000ENSANAG00000037222EGLN310099.160Aotus_nancymaae
ENSG00000129521EGLN310086.076ENSACLG00000007509egln39866.239Astatotilapia_calliptera
ENSG00000129521EGLN39984.615ENSAMXG00000002702egln310066.109Astyanax_mexicanus
ENSG00000129521EGLN39998.718ENSCAFG00000013182EGLN38894.574Canis_familiaris
ENSG00000129521EGLN399100.000ENSTSYG00000002267-10099.160Carlito_syrichta
ENSG00000129521EGLN39798.701ENSCAPG00000014697-8988.136Cavia_aperea
ENSG00000129521EGLN39797.403ENSCGRG00000000933-10097.368Cricetulus_griseus_crigri
ENSG00000129521EGLN310086.076ENSHBUG00000015449egln39566.239Haplochromis_burtoni
ENSG00000129521EGLN39984.615ENSIPUG00000001099egln39868.696Ictalurus_punctatus
ENSG00000129521EGLN39989.744ENSLOCG00000009500egln310075.417Lepisosteus_oculatus
ENSG00000129521EGLN39985.897ENSMAMG00000000031egln39768.376Mastacembelus_armatus
ENSG00000129521EGLN310086.076ENSMZEG00005001042egln38564.103Maylandia_zebra
ENSG00000129521EGLN310094.937ENSMGAG00000012453EGLN310091.870Meleagris_gallopavo
ENSG00000129521EGLN39784.416ENSMMOG00000013295egln39776.068Mola_mola
ENSG00000129521EGLN310078.481ENSORLG00000018068egln39463.559Oryzias_latipes
ENSG00000129521EGLN310078.481ENSORLG00020010688egln39462.979Oryzias_latipes_hni
ENSG00000129521EGLN310078.481ENSORLG00015007682egln39462.553Oryzias_latipes_hsok
ENSG00000129521EGLN310078.481ENSOMEG00000005866egln39762.553Oryzias_melastigma
ENSG00000129521EGLN310099.310ENSPTIG00000017846EGLN310099.310Panthera_tigris_altaica
ENSG00000129521EGLN39980.769ENSPFOG00000010877egln39465.812Poecilia_formosa
ENSG00000129521EGLN39980.769ENSPLAG00000023868egln39765.812Poecilia_latipinna
ENSG00000129521EGLN39980.769ENSPMEG00000002851egln39765.812Poecilia_mexicana
ENSG00000129521EGLN39982.051ENSPREG00000002945egln39766.239Poecilia_reticulata
ENSG00000129521EGLN39792.405ENSPCOG00000013527-10092.562Propithecus_coquereli
ENSG00000129521EGLN39994.872ENSPVAG00000002170EGLN310091.509Pteropus_vampyrus
ENSG00000129521EGLN39985.897ENSPNAG00000008631egln39968.644Pygocentrus_nattereri
ENSG00000129521EGLN39989.744ENSSFOG00015014197egln38067.662Scleropages_formosus
ENSG00000129521EGLN39984.615ENSSDUG00000010655egln39768.240Seriola_dumerili
ENSG00000129521EGLN39797.403ENSSPUG00000013593-10094.958Sphenodon_punctatus
ENSG00000129521EGLN39983.333ENSSPAG00000007191egln39865.417Stegastes_partitus
ENSG00000129521EGLN310078.481ENSTNIG00000002846egln39264.414Tetraodon_nigroviridis
ENSG00000129521EGLN39998.718ENSUMAG00000010391EGLN39198.333Ursus_maritimus
ENSG00000129521EGLN39798.701ENSVVUG00000029949-10099.160Vulpes_vulpes
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0001666response to hypoxia20978507.IEPProcess
GO:0005506iron ion binding-IEAFunction
GO:0005515protein binding15721254.16511565.17353276.19584355.20849813.21575608.21620138.21988832.22286099.25416956.26972000.IPIFunction
GO:0005634nucleus12615973.IDAComponent
GO:0005654nucleoplasm-TASComponent
GO:0005737cytoplasm12615973.IDAComponent
GO:0005829cytosol-IDAComponent
GO:0005829cytosol-TASComponent
GO:0006915apoptotic process20978507.IEPProcess
GO:0006919activation of cysteine-type endopeptidase activity involved in apoptotic process20978507.IEPProcess
GO:0006974cellular response to DNA damage stimulus-IEAProcess
GO:0016706oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors22955912.IDAFunction
GO:0018126protein hydroxylation19584355.IDAProcess
GO:0018401peptidyl-proline hydroxylation to 4-hydroxy-L-proline11598268.IDAProcess
GO:0031418L-ascorbic acid binding-IEAFunction
GO:0031545peptidyl-proline 4-dioxygenase activity12615973.12788921.22286099.EXPFunction
GO:0031545peptidyl-proline 4-dioxygenase activity11598268.IDAFunction
GO:0042127regulation of cell proliferation20978507.IEPProcess
GO:0043523regulation of neuron apoptotic process-ISSProcess
GO:0055114oxidation-reduction process-IEAProcess
GO:0061418regulation of transcription from RNA polymerase II promoter in response to hypoxia-TASProcess
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