EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
22948157	Prolyl hydroxylase 3 (PHD3) modulates catabolic effects of tumor necrosis factor-α (TNF-α) on cells of the nucleus pulposus through co-activation of nuclear factor κB (NF-κB)/p65 signaling.	J Biol Chem	2012 Nov 16	Fujita N	doi: 10.1074/jbc.M112.375964
21748337	The expression of prolyl hydroxylase domain enzymes are up-regulated and negatively correlated with Bcl-2 in non-small cell lung cancer.	Mol Cell Biochem	2011 Dec	Chen S	doi: 10.1007/s11010-011-0976-1
19786027	Prolyl hydroxylase-3 is down-regulated in colorectal cancer cells and inhibits IKKbeta independent of hydroxylase activity.	Gastroenterology	2010 Feb	Xue J	doi: 10.1053/j.gastro.2009.09.049
28901473	PHD3 affects gastric cancer progression by negatively regulating HIF1A.	Mol Med Rep	2017 Nov	Xia YJ	doi: 10.3892/mmr.2017.7455
21887331	Overexpression of the HIF hydroxylases PHD1, PHD2, PHD3 and FIH are individually and collectively unfavorable prognosticators for NSCLC survival.	PLoS One	2011	Andersen S	doi: 10.1371/journal.pone.0023847
18927305	Overexpression of the oxygen sensors PHD-1, PHD-2, PHD-3, and FIH Is associated with tumor aggressiveness in pancreatic endocrine tumors.	Clin Cancer Res	2008 Oct 15	Couvelard A	doi: 10.1158/1078-0432.CCR-07-5258.
20028863	Prolyl hydroxylases 2 and 3 act in gliomas as protective negative feedback regulators of hypoxia-inducible factors.	Cancer Res	2010 Jan 1	Henze AT	doi: 10.1158/0008-5472.CAN-09-1876
28099905	Prolyl hydroxylase domain protein 3 and asparaginyl hydroxylase factor inhibiting HIF-1 levels are predictive of tumoral behavior and prognosis in hepatocellular carcinoma.	Oncotarget	2017 Feb 21	Ma M	doi: 10.18632/oncotarget.14677.
22290580	Overexpression of the HIF hydroxylase PHD3 is a favorable prognosticator for gastric cancer.	Med Oncol	2012 Dec	Su C	-
25081707	Expression of hypoxia-inducible factor prolyl hydroxylase 3 HIFPH3 in human non-small cell lung cancer (NSCLC) and its correlation with prognosis.	Asian Pac J Cancer Prev	2014	Chu X	-
23533015	Prolyl hydroxylase 3 inhibited the tumorigenecity of gastric cancer cells.	Mol Carcinog	2014 Sep	Cui L	doi: 10.1002/mc.22025
21297970	Aberrant promoter CpG methylation is a mechanism for impaired PHD3 expression in a diverse set of malignant cells.	PLoS One	2011 Jan 28	Place TL	doi: 10.1371/journal.pone.0014617.
23601303	[Advances of hypoxia and lung cancer].	Zhongguo Fei Ai Za Zhi	2013 Apr	Li X	doi: 10.3779/j.issn.1009-3419.2013.04.08.
26372732	Distinct breast cancer stem/progenitor cell populations require either HIF1α or loss of PHD3 to expand under hypoxic conditions.	Oncotarget	2015 Oct 13	Iriondo O	doi: 10.18632/oncotarget.5564.
20727020	DNA methylation analysis of the HIF-1α prolyl hydroxylase domain genes PHD1, PHD2, PHD3 and the factor inhibiting HIF gene FIH in invasive breast carcinomas.	Histopathology	2010 Sep	Huang KT	doi: 10.1111/j.1365-2559.2010.03633.x
25542265	Increased expression of PHD3 represses the HIF-1 signaling pathway and contributes to poor neovascularization in pancreatic ductal adenocarcinoma.	J Gastroenterol	2015 Sep	Tanaka T	doi: 10.1007/s00535-014-1030-3
21620138	Pyruvate kinase M2 is a PHD3-stimulated coactivator for hypoxia-inducible factor 1.	Cell	2011 May 27	Luo W	doi: 10.1016/j.cell.2011.03.054.
26921340	Prolyl Hydroxylase 3 Attenuates MCL-1-Mediated ATP Production to Suppress the Metastatic Potential of Colorectal Cancer Cells.	Cancer Res	2016 Apr 15	Radhakrishnan P	doi: 10.1158/0008-5472.CAN-15-1474
27635760	PHD3 Loss in Cancer Enables Metabolic Reliance on Fatty Acid Oxidation via Deactivation of ACC2.	Mol Cell	2016 Sep 15	German NJ	doi: 10.1016/j.molcel.2016.08.014.
29339541	PHD3 Controls Lung Cancer Metastasis and Resistance to EGFR Inhibitors through TGFα.	Cancer Res	2018 Apr 1	Dopeso H	doi: 10.1158/0008-5472.CAN-17-1346
29688807	Acetylation-mediated Siah2 stabilization enhances PHD3 degradation in Helicobacter pylori-infected gastric epithelial cancer cells.	FASEB J	2018 Oct	Kokate SB	doi: 10.1096/fj.201701344RRR

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
ACC	chr14	33950365	Intron	novel		0.65
BLCA	chr14	33950383	Intron	novel		0.11
BLCA	chr14	33950821	5'UTR	NA		0.14
BRCA	chr14	33950305	Intron	novel		0.2
BRCA	chr14	33950796	5'UTR	rs755692956		0.16
CESC	chr14	33931167	Missense_Mutation	NA	V136M	0.1
CESC	chr14	33950796	5'UTR	rs755692956		0.35
CESC	chr14	33950612	Silent	novel	V47V	0.29
CHOL	chr14	33925731	3'UTR	novel		0.11
COAD	chr14	33931193	Missense_Mutation	NA	G127E	0.41
COAD	chr14	33926999	Missense_Mutation	novel	E217K	0.07
COAD	chr14	33929083	Missense_Mutation	rs375310922	A203T	0.27
COAD	chr14	33950460	Missense_Mutation	NA	I98T	0.12	2OG-FeII_Oxy
COAD	chr14	33950672	Silent	novel	G27G	0.17
COAD	chr14	33925838	3'UTR	novel		0.13
ESCA	chr14	33925687	3'UTR	novel		0.3
GBM	chr14	33925856	3'UTR	novel		0.05
GBM	chr14	33950807	5'UTR	novel		0.14
HNSC	chr14	33950874	5'UTR	novel		0.67
HNSC	chr14	33950821	5'UTR	novel		0.14
HNSC	chr14	33950742	Missense_Mutation	novel	G4E	0.34
HNSC	chr14	33950372	Intron	novel		0.41
HNSC	chr14	33950711	Missense_Mutation	novel	I14M	0.35
KIRP	chr14	33950884	5'UTR	novel		0.5
LGG	chr14	33950666	Silent	rs752377366	C29C	0.31
LUAD	chr14	33950391	Splice_Region	novel		0.51
LUAD	chr14	33931188	Nonsense_Mutation	novel	G129*	0.15
LUAD	chr14	33925870	3'UTR	novel		0.48
LUAD	chr14	33950705	Silent	NA	L16L	0.13
LUAD	chr14	33927034	Splice_Site	NA	X205_splice	0.12
LUAD	chr14	33950494	Missense_Mutation	novel	G87C	0.25	2OG-FeII_Oxy
LUAD	chr14	33950495	Missense_Mutation	novel	E86D	0.25	2OG-FeII_Oxy
LUAD	chr14	33931152	Missense_Mutation	novel	G141R	0.28
LUAD	chr14	33950738	Silent	rs61758135	H5H	0.21
LUAD	chr14	33950594	Silent	NA	T53T	0.37
LUAD	chr14	33931206	Missense_Mutation	NA	A123S	0.21
LUAD	chr14	33925752	3'UTR	novel		0.6
LUAD	chr14	33950432	Missense_Mutation	novel	S107R	0.18	2OG-FeII_Oxy
LUAD	chr14	33929116	Missense_Mutation	NA	R192C	0.09
LUSC	chr14	33929194	Missense_Mutation	rs749363666	R166W	0.58
LUSC	chr14	33925874	3'UTR	novel		0.23
LUSC	chr14	33950450	Silent	NA	L101L	0.28
LUSC	chr14	33950451	Missense_Mutation	NA	L101P	0.28	2OG-FeII_Oxy
LUSC	chr14	33950837	5'UTR	novel		0.48
LUSC	chr14	33950580	Missense_Mutation	NA	D58V	0.35	2OG-FeII_Oxy
LUSC	chr14	33950809	5'UTR	novel		0.2
LUSC	chr14	33931153	Missense_Mutation	novel	N140K	0.32
LUSC	chr14	33931171	Silent	NA	R134R	0.25
LUSC	chr14	33950556	Missense_Mutation	novel	A66V	0.31	2OG-FeII_Oxy
OV	chr14	33950861	5'UTR	novel		0.18
PAAD	chr14	33950624	Silent	novel	V43V	0.15
PRAD	chr14	33950220	Intron	novel		0.38
PRAD	chr14	33950492	Silent	novel	G87G	0.24
SKCM	chr14	33925862	3'UTR	novel		0.14
SKCM	chr14	33950651	Silent	NA	F34F	0.4
SKCM	chr14	33929151	Missense_Mutation	novel	P180L	0.32
SKCM	chr14	33950581	Missense_Mutation	NA	D58N	0.47	2OG-FeII_Oxy
SKCM	chr14	33929180	Silent	NA	E170E	0.21
STAD	chr14	33950821	5'UTR	NA		0.21
STAD	chr14	33931123	Silent	rs762316505	Y150Y	0.05
THYM	chr14	33931201	Silent	novel	C124C	0.11
UCEC	chr14	33929101	Missense_Mutation	NA	E197K	0.37
UCEC	chr14	33925636	3'UTR	rs553715770		0.18
UCEC	chr14	33950244	Intron	novel		0.38
UCEC	chr14	33950785	5'UTR	rs767045645		0.48
UCEC	chr14	33950673	Missense_Mutation	novel	G27D	0.22	2OG-FeII_Oxy
UCEC	chr14	33925518	3'UTR	novel		0.27
UCEC	chr14	33950717	Missense_Mutation	novel	E12D	0.24
UCEC	chr14	33950489	Silent	NA	C88C	0.36
UCEC	chr14	33925518	3'UTR	novel		0.15
UCEC	chr14	33931176	Missense_Mutation	novel	V133I	0.26
UCEC	chr14	33931197	Missense_Mutation	novel	P126S	0.29
UCEC	chr14	33929116	Missense_Mutation	NA	R192C	0.43
UCEC	chr14	33925849	3'UTR	novel		0.36
UCEC	chr14	33950245	Intron	novel		0.39
UCEC	chr14	33929101	Missense_Mutation	NA	E197K	0.38
UCEC	chr14	33929176	Missense_Mutation	novel	K172E	0.55
UCEC	chr14	33925828	3'UTR	novel		0.08
UCEC	chr14	33926979	Missense_Mutation	NA	K223N	0.16
UCEC	chr14	33929122	Missense_Mutation	NA	S190T	0.36
UCEC	chr14	33926979	Missense_Mutation	NA	K223N	0.4
UCEC	chr14	33925447	3'UTR	novel		0.33
UCEC	chr14	33931148	Missense_Mutation	novel	D142G	0.37
UCEC	chr14	33950263	Intron	novel		0.36
UCEC	chr14	33950669	Missense_Mutation	novel	F28L	0.64	2OG-FeII_Oxy

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
ACC	DEL	0.1778	0.19769
CHOL	DEL	0.3611	0.00040262
KIRP	DEL	0.1736	0.085174
PAAD	DEL	0.0652	0.11332

Survival Analysis

Cancer	P-value	Q-value
THYM	0.014	Kaplan-Meier Survival Analysis
KIRC	0.0078	Kaplan-Meier Survival Analysis
MESO	0.0039	Kaplan-Meier Survival Analysis
HNSC	0.049	Kaplan-Meier Survival Analysis
SKCM	0.0013	Kaplan-Meier Survival Analysis
PAAD	0.045	Kaplan-Meier Survival Analysis
CESC	0.0081	Kaplan-Meier Survival Analysis
KICH	0.034	Kaplan-Meier Survival Analysis
UCEC	0.05	Kaplan-Meier Survival Analysis
LIHC	0.0001	Kaplan-Meier Survival Analysis
DLBC	0.01	Kaplan-Meier Survival Analysis
LGG	0.0073	Kaplan-Meier Survival Analysis
LUAD	0.00059	Kaplan-Meier Survival Analysis
UVM	0.0017	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBDs

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000129521 (Gene tree)
Gene ID: 112399
Gene Symbol: EGLN3
Alias: PHD3|HIFPH3
Full Name: egl-9 family hypoxia inducible factor 3
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 538,560 bases
Position: chr14:33,924,215-34,462,774
Accession: 14661
RBP type: canonical RBP
Summary: EGLN3 (Egl-9 Family Hypoxia Inducible Factor 3) is a Protein Coding gene. Diseases associated with EGLN3 include Hypoxia and Chronic Mountain Sickness. Among its related pathways are CDK-mediated phosphorylation and removal of Cdc6 and HIF Repressor Pathways. Gene Ontology (GO) annotations related to this gene include oxidoreductase activity and oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen. An important paralog of this gene is EGLN1.

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000447470	2OG-FeII_Oxy	PF03171.20	1.5e-05	1	1

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
20460131	Molecular mechanism of MLL PHD3 and RNA recognition by the Cyp33 RRM domain.	J Mol Biol	2010 Jul 9	Hom RA	doi: 10.1016/j.jmb.2010.04.067

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000546681	EGLN3-204	581	-	-	- (aa)	-	-
ENST00000551935	EGLN3-208	575	-	-	- (aa)	-	-
ENST00000553215	EGLN3-209	1004	-	ENSP00000447470	145 (aa)	-	F8W1G2
ENST00000487915	EGLN3-203	848	-	ENSP00000451316	79 (aa)	-	G3V3M1
ENST00000547327	EGLN3-205	2849	-	ENSP00000446572	148 (aa)	-	F8VR39
ENST00000556785	EGLN3-210	864	-	-	- (aa)	-	-
ENST00000250457	EGLN3-201	2709	-	ENSP00000250457	239 (aa)	-	Q9H6Z9
ENST00000550114	EGLN3-207	566	-	-	- (aa)	-	-
ENST00000557521	EGLN3-211	658	-	-	- (aa)	-	-
ENST00000464521	EGLN3-202	352	-	-	- (aa)	-	-
ENST00000548285	EGLN3-206	535	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000129521's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa04066	HIF-1 signaling pathway	KEGG
hsa05200	Pathways in cancer	KEGG
hsa05211	Renal cell carcinoma	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000129521	Fibrinogen	5.07816651189167E-5	17903294
ENSG00000129521	Fibrinogen	2.38174494351447E-6	17903294
ENSG00000129521	Varicose Veins	8.3543782868123E-5	-
ENSG00000129521	Osteoporosis	6.49678632189676E-5	17903295
ENSG00000129521	Mental Competency	1.84886412635623E-6	17903295
ENSG00000129521	Stroke	5.5631319E-005	19369658
ENSG00000129521	Neuroblastoma	1.71e-005	23222812
ENSG00000129521	Waist-Hip Ratio	4.4450000E-006	-
ENSG00000129521	Waist-Hip Ratio	1.0540000E-005	-
ENSG00000129521	Basophils	4.4380000E-005	-
ENSG00000129521	Platelet Function Tests	1.1900000E-007	-
ENSG00000129521	Platelet Function Tests	4.7000000E-007	-
ENSG00000129521	Child Development Disorders, Pervasive	6.5441600E-005	-
ENSG00000129521	Child Development Disorders, Pervasive	1.4527000E-005	-
ENSG00000129521	Child Development Disorders, Pervasive	6.0145500E-005	-
ENSG00000129521	Child Development Disorders, Pervasive	1.0189500E-005	-
ENSG00000129521	alpha-carotene	4.5640000E-006	-
ENSG00000129521	alpha-carotene	2.8980000E-006	-
ENSG00000129521	Taste Perception	3.2450000E-005	-
ENSG00000129521	Age-Related Hearing Impairment 1	8E-6	24939585
ENSG00000129521	3-hydroxy-1-methylpropylmercapturic acid	3E-6	26053186
ENSG00000129521	Smoking	3E-6	26053186
ENSG00000129521	Rest	8E-7	27126917
ENSG00000129521	Celiac Disease	4E-6	23936387

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000129521	rs1958581	14	34332393	?	Age-related hearing impairment	24939585	[NR] unit decrease	0.1353	EFO_0005782
ENSG00000129521	rs57574493	14	34149063	G	Daytime sleep phenotypes	27126917	[0.4-0.98] unit increase	0.6878	EFO_0007828
ENSG00000129521	rs797324	14	34136247	C	Daytime sleep phenotypes	27126917	[0.34-0.79] unit increase	0.5679	EFO_0007828
ENSG00000129521	rs1958589	14	34375170	C	Celiac disease	23936387			EFO_0001060
ENSG00000129521	rs191936903	14	34027246	?	3-hydroxy-1-methylpropylmercapturic acid levels in smokers	26053186	[NR] unit decrease	1.1003	EFO_0004318\|EFO_0007015
ENSG00000129521	rs10142635	14	34423401	A	Heart rate response to beta blockers (atenolol add-on therapy)	29478026	[4.16-9.06] bpm decrease	6.61	EFO_0007766\|EFO_0004326
ENSG00000129521	rs76827035	14	34324633	G	Eotaxin levels	27989323	[0.1-0.255] SD units increase	0.1776	EFO_0008122
ENSG00000129521	rs797343	14	34177063	T	Hematocrit	27863252	[0.015-0.03] unit increase	0.02249192	EFO_0004348
ENSG00000129521	rs12879626	14	34251928	T	Intraocular pressure	29785010	[0.054-0.104] unit increase	0.079	EFO_0004695
ENSG00000129521	rs74412765	14	34053698	T	Reasoning	29907492	[NR] unit decrease	1.7	EFO_0004350
ENSG00000129521	rs797343	14	34177063	?	Red blood cell count	30595370			EFO_0004305
ENSG00000129521	rs35833468	14	33974720	?	Alzheimer's disease (late onset)	30820047	[1.04-1.12]	1.0869565	EFO_1001870

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000129521's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000129521	EGLN3	99	83.333	ENSAPOG00000007757	egln3	99	64.502	Acanthochromis_polyacanthus
ENSG00000129521	EGLN3	99	80.769	ENSAOCG00000023534	egln3	99	62.338	Amphiprion_ocellaris
ENSG00000129521	EGLN3	97	79.221	ENSAOCG00000000273	-	98	75.424	Amphiprion_ocellaris
ENSG00000129521	EGLN3	97	79.221	ENSAOCG00000019598	-	98	76.271	Amphiprion_ocellaris
ENSG00000129521	EGLN3	99	80.769	ENSAPEG00000013864	egln3	100	61.181	Amphiprion_percula
ENSG00000129521	EGLN3	99	83.333	ENSAPEG00000000070	-	100	62.393	Amphiprion_percula
ENSG00000129521	EGLN3	99	84.615	ENSATEG00000016315	egln3	85	83.810	Anabas_testudineus
ENSG00000129521	EGLN3	97	100.000	ENSANAG00000037222	EGLN3	100	99.160	Aotus_nancymaae
ENSG00000129521	EGLN3	100	86.076	ENSACLG00000007509	egln3	98	66.239	Astatotilapia_calliptera
ENSG00000129521	EGLN3	99	84.615	ENSAMXG00000002702	egln3	100	66.109	Astyanax_mexicanus
ENSG00000129521	EGLN3	99	98.718	ENSCAFG00000013182	EGLN3	88	94.574	Canis_familiaris
ENSG00000129521	EGLN3	99	100.000	ENSTSYG00000002267	-	100	99.160	Carlito_syrichta
ENSG00000129521	EGLN3	97	98.701	ENSCAPG00000014697	-	89	88.136	Cavia_aperea
ENSG00000129521	EGLN3	97	97.403	ENSCGRG00000000933	-	100	97.368	Cricetulus_griseus_crigri
ENSG00000129521	EGLN3	100	86.076	ENSHBUG00000015449	egln3	95	66.239	Haplochromis_burtoni
ENSG00000129521	EGLN3	99	84.615	ENSIPUG00000001099	egln3	98	68.696	Ictalurus_punctatus
ENSG00000129521	EGLN3	99	89.744	ENSLOCG00000009500	egln3	100	75.417	Lepisosteus_oculatus
ENSG00000129521	EGLN3	99	85.897	ENSMAMG00000000031	egln3	97	68.376	Mastacembelus_armatus
ENSG00000129521	EGLN3	100	86.076	ENSMZEG00005001042	egln3	85	64.103	Maylandia_zebra
ENSG00000129521	EGLN3	100	94.937	ENSMGAG00000012453	EGLN3	100	91.870	Meleagris_gallopavo
ENSG00000129521	EGLN3	97	84.416	ENSMMOG00000013295	egln3	97	76.068	Mola_mola
ENSG00000129521	EGLN3	100	78.481	ENSORLG00000018068	egln3	94	63.559	Oryzias_latipes
ENSG00000129521	EGLN3	100	78.481	ENSORLG00020010688	egln3	94	62.979	Oryzias_latipes_hni
ENSG00000129521	EGLN3	100	78.481	ENSORLG00015007682	egln3	94	62.553	Oryzias_latipes_hsok
ENSG00000129521	EGLN3	100	78.481	ENSOMEG00000005866	egln3	97	62.553	Oryzias_melastigma
ENSG00000129521	EGLN3	100	99.310	ENSPTIG00000017846	EGLN3	100	99.310	Panthera_tigris_altaica
ENSG00000129521	EGLN3	99	80.769	ENSPFOG00000010877	egln3	94	65.812	Poecilia_formosa
ENSG00000129521	EGLN3	99	80.769	ENSPLAG00000023868	egln3	97	65.812	Poecilia_latipinna
ENSG00000129521	EGLN3	99	80.769	ENSPMEG00000002851	egln3	97	65.812	Poecilia_mexicana
ENSG00000129521	EGLN3	99	82.051	ENSPREG00000002945	egln3	97	66.239	Poecilia_reticulata
ENSG00000129521	EGLN3	97	92.405	ENSPCOG00000013527	-	100	92.562	Propithecus_coquereli
ENSG00000129521	EGLN3	99	94.872	ENSPVAG00000002170	EGLN3	100	91.509	Pteropus_vampyrus
ENSG00000129521	EGLN3	99	85.897	ENSPNAG00000008631	egln3	99	68.644	Pygocentrus_nattereri
ENSG00000129521	EGLN3	99	89.744	ENSSFOG00015014197	egln3	80	67.662	Scleropages_formosus
ENSG00000129521	EGLN3	99	84.615	ENSSDUG00000010655	egln3	97	68.240	Seriola_dumerili
ENSG00000129521	EGLN3	97	97.403	ENSSPUG00000013593	-	100	94.958	Sphenodon_punctatus
ENSG00000129521	EGLN3	99	83.333	ENSSPAG00000007191	egln3	98	65.417	Stegastes_partitus
ENSG00000129521	EGLN3	100	78.481	ENSTNIG00000002846	egln3	92	64.414	Tetraodon_nigroviridis
ENSG00000129521	EGLN3	99	98.718	ENSUMAG00000010391	EGLN3	91	98.333	Ursus_maritimus
ENSG00000129521	EGLN3	97	98.701	ENSVVUG00000029949	-	100	99.160	Vulpes_vulpes

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0001666	response to hypoxia	20978507.	IEP	Process
GO:0005506	iron ion binding	-	IEA	Function
GO:0005515	protein binding	15721254.16511565.17353276.19584355.20849813.21575608.21620138.21988832.22286099.25416956.26972000.	IPI	Function
GO:0005634	nucleus	12615973.	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005737	cytoplasm	12615973.	IDA	Component
GO:0005829	cytosol	-	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0006915	apoptotic process	20978507.	IEP	Process
GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	20978507.	IEP	Process
GO:0006974	cellular response to DNA damage stimulus	-	IEA	Process
GO:0016706	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors	22955912.	IDA	Function
GO:0018126	protein hydroxylation	19584355.	IDA	Process
GO:0018401	peptidyl-proline hydroxylation to 4-hydroxy-L-proline	11598268.	IDA	Process
GO:0031418	L-ascorbic acid binding	-	IEA	Function
GO:0031545	peptidyl-proline 4-dioxygenase activity	12615973.12788921.22286099.	EXP	Function
GO:0031545	peptidyl-proline 4-dioxygenase activity	11598268.	IDA	Function
GO:0042127	regulation of cell proliferation	20978507.	IEP	Process
GO:0043523	regulation of neuron apoptotic process	-	ISS	Process
GO:0055114	oxidation-reduction process	-	IEA	Process
GO:0061418	regulation of transcription from RNA polymerase II promoter in response to hypoxia	-	TAS	Process

EuRBPDB

Note: to get the extension of tumor abbreviations.

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Input Drug :

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Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBDs

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.