EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
28122867	The Genetic Basis of Hepatosplenic T-cell Lymphoma.	Cancer Discov	2017 Apr	McKinney M	doi: 10.1158/2159-8290.CD-16-0330
25283999	Stabilization and targeting of INO80 to replication forks by BAP1 during normal DNA synthesis.	Nat Commun	2014 Oct 6	Lee HS	doi: 10.1038/ncomms6128.
27641337	INO80 is required for oncogenic transcription and tumor growth in non-small cell lung cancer.	Oncogene	2017 Mar	Zhang S	doi: 10.1038/onc.2016.311
27750218	Ino80 promotes cervical cancer tumorigenesis by activating Nanog expression.	Oncotarget	2016 Nov 1	Hu J	doi: 10.18632/oncotarget.12667.

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
ACC	chr15	41021099	Nonsense_Mutation	novel	Y1025*	0.36
ACC	chr15	40980240	Missense_Mutation	rs545022339	P1552S	0.22
BLCA	chr15	41079886	Nonsense_Mutation	NA	K316*	0.13
BLCA	chr15	41058683	Silent	rs758964021	Q647Q	0.18
BLCA	chr15	41055250	Missense_Mutation	novel	E729K	0.14
BLCA	chr15	41070469	Missense_Mutation	novel	E562K	0.18	ResIII
BLCA	chr15	40985343	Missense_Mutation	novel	E1306Q	0.5
BLCA	chr15	41055288	Missense_Mutation	NA	D716V	0.17
BLCA	chr15	41096244	Nonsense_Mutation	NA	Q23*	0.1
BLCA	chr15	41074405	Missense_Mutation	novel	G431E	0.45
BLCA	chr15	41027611	Silent	NA	C1011C	0.24
BLCA	chr15	41021021	Silent	NA	L1051L	0.18
BLCA	chr15	41095836	Missense_Mutation	NA	S79L	0.28
BLCA	chr15	40980371	Missense_Mutation	NA	S1508L	0.16
BLCA	chr15	40987900	Missense_Mutation	novel	Q1215H	0.29
BLCA	chr15	40987136	Missense_Mutation	novel	E1263K	0.41
BLCA	chr15	41021107	Missense_Mutation	novel	D1023Y	0.35
BLCA	chr15	41070526	Missense_Mutation	NA	D543N	0.26	ResIII
BLCA	chr15	40982966	Missense_Mutation	NA	R1450Q	0.15
BLCA	chr15	41074463	Frame_Shift_Del	novel	*E412Kfs4**	0.26
BLCA	chr15	40984340	Missense_Mutation	novel	D1312H	0.23
BLCA	chr15	41047445	Missense_Mutation	rs750579112	E900Q	0.53
BLCA	chr15	41048255	Silent	novel	P866P	0.44
BLCA	chr15	40997550	Silent	novel	I1183I	0.65
BLCA	chr15	41058650	Missense_Mutation	novel	K658N	0.27	ResIII
BLCA	chr15	41085523	Missense_Mutation	novel	S240F	0.21
BRCA	chr15	41092119	Frame_Shift_Del	NA	*E149Nfs74**	0.12
BRCA	chr15	41079898	Missense_Mutation	rs780868252	H312Y	0.26
BRCA	chr15	41071999	Silent	NA	N485N	0.27
BRCA	chr15	41027621	Missense_Mutation	NA	S1008C	0.13
BRCA	chr15	41092032	Missense_Mutation	NA	K178E	0.18
BRCA	chr15	41095831	Missense_Mutation	NA	L81F	0.32
BRCA	chr15	41049406	Silent	rs181458553	P819P	0.1
BRCA	chr15	41095785	Missense_Mutation	novel	Y96F	0.13
BRCA	chr15	41072054	Missense_Mutation	NA	R467M	0.43
BRCA	chr15	40982993	Missense_Mutation	NA	A1441V	0.3
CESC	chr15	40983778	Silent	NA	V1407V	0.27
CESC	chr15	40987848	Missense_Mutation	NA	R1233C	0.42
CESC	chr15	40982966	Missense_Mutation	NA	R1450Q	0.14
CESC	chr15	40978949	3'UTR	novel		0.21
CESC	chr15	40987106	Missense_Mutation	NA	E1273K	0.54
CESC	chr15	41055316	Nonsense_Mutation	NA	E707*	0.25
CESC	chr15	41053966	Missense_Mutation	NA	R746T	0.42
CESC	chr15	41058730	Missense_Mutation	novel	Q632E	0.18	ResIII
CESC	chr15	41079779	Missense_Mutation	NA	E351D	0.26
CESC	chr15	41005623	Missense_Mutation	novel	R1156M	0.11
CESC	chr15	40983906	Missense_Mutation	novel	E1365K	0.39
CESC	chr15	40980218	3'UTR	novel		0.32
CESC	chr15	41081024	Missense_Mutation	novel	R308Q	0.15
CHOL	chr15	41053994	Missense_Mutation	novel	M737V	0.28
COAD	chr15	41096265	Silent	rs755496508	L16L	0.34
COAD	chr15	40997592	Silent	NA	I1169I	0.36
COAD	chr15	41069631	Nonsense_Mutation	novel	S574*	0.16	ResIII
COAD	chr15	41056702	Missense_Mutation	NA	R664S	0.26	ResIII
COAD	chr15	40982919	Missense_Mutation	novel	G1466R	0.34
COAD	chr15	40980142	3'UTR	novel		0.4
COAD	chr15	40980143	3'UTR	novel		0.4
COAD	chr15	41045023	Missense_Mutation	rs572481309	R930C	0.38
COAD	chr15	41059923	Silent	NA	L596L	0.44
COAD	chr15	41085515	Missense_Mutation	rs548696805	R243C	0.31
COAD	chr15	40984322	Frame_Shift_Del	novel	*R1318Gfs6**	0.16
COAD	chr15	41054014	Missense_Mutation	NA	N730S	0.36
COAD	chr15	41005671	Missense_Mutation	NA	R1140M	0.16
COAD	chr15	41048233	Frame_Shift_Ins	novel	*R874Ifs42**	0.05
COAD	chr15	41069651	Nonsense_Mutation	NA	W567*	0.46	ResIII
COAD	chr15	41092106	Missense_Mutation	NA	S153I	0.42
COAD	chr15	40982872	In_Frame_Del	novel	N1481del	0.25
DLBC	chr15	40985351	Missense_Mutation	novel	K1303R	0.23
DLBC	chr15	40997570	Nonsense_Mutation	novel	R1177*	0.08
ESCA	chr15	40997576	Missense_Mutation	novel	S1175R	0.39
ESCA	chr15	41079706	Missense_Mutation	rs758451886	R376W	0.38
GBM	chr15	41095651	Missense_Mutation	novel	G111R	0.29
GBM	chr15	41074416	Silent	rs574924831	I427I	0.38
GBM	chr15	41081024	Missense_Mutation	novel	R308Q	0.04
GBM	chr15	40980192	3'UTR	novel		0.1
GBM	chr15	41085380	Missense_Mutation	novel	E288Q	0.05
GBM	chr15	41092104	Silent	novel	R154R	0.1
GBM	chr15	40987909	Silent	novel	R1212R	0.09
HNSC	chr15	41005656	Frame_Shift_Del	novel	*M1145Rfs30**	0.09
HNSC	chr15	40980347	Missense_Mutation	novel	S1516F	0.37
HNSC	chr15	41079819	Missense_Mutation	rs749332663	R338H	0.27
HNSC	chr15	41056672	Missense_Mutation	rs370606160	R674W	0.35	ResIII
HNSC	chr15	40983877	Silent	rs775846922	D1374D	0.18
HNSC	chr15	41020975	Nonsense_Mutation	novel	Q1067*	0.22
HNSC	chr15	41058730	Nonsense_Mutation	novel	Q632*	0.23	ResIII
HNSC	chr15	41085561	In_Frame_Ins	novel	K228dup	0.15
HNSC	chr15	41044940	Silent	novel	L957L	0.35
KIRC	chr15	41072006	Missense_Mutation	NA	A483E	0.29
KIRC	chr15	40987161	Silent	NA	F1254F	0.3
KIRC	chr15	41048271	Frame_Shift_Ins	novel	*L861Sfs29**	0.04
KIRP	chr15	41021111	Silent	novel	P1021P	0.44
KIRP	chr15	41095787	Silent	NA	T95T	0.29
LAML	chr15	41070517	Missense_Mutation	novel	G546S	0.03	ResIII
LGG	chr15	41016109	Silent	novel	T1127T	0.38
LGG	chr15	41047418	Missense_Mutation	novel	L909F	0.52
LGG	chr15	41055365	Splice_Site	novel	X691_splice	0.18
LIHC	chr15	40987927	Frame_Shift_Del	novel	*M1207Wfs7**	0.26
LIHC	chr15	41096319	5'UTR	novel		0.43
LIHC	chr15	41021076	Missense_Mutation	novel	Y1033F	0.32
LIHC	chr15	41095815	Missense_Mutation	NA	G86V	0.33
LIHC	chr15	41085545	Missense_Mutation	NA	E233K	0.19
LIHC	chr15	41021011	Missense_Mutation	novel	P1055A	0.43
LUAD	chr15	41055250	Nonsense_Mutation	NA	E729*	0.42
LUAD	chr15	40983787	Silent	novel	T1404T	0.2
LUAD	chr15	40980174	3'UTR	novel		0.21
LUAD	chr15	41071932	Missense_Mutation	novel	I508F	0.05
LUAD	chr15	41092098	Missense_Mutation	novel	E156Q	0.1
LUAD	chr15	41055304	Nonsense_Mutation	novel	E711*	0.11
LUAD	chr15	41058744	Missense_Mutation	novel	V627G	0.07	ResIII
LUAD	chr15	41058732	Missense_Mutation	novel	Y631F	0.12	ResIII
LUAD	chr15	41096243	Missense_Mutation	novel	Q23L	0.32
LUAD	chr15	41095787	Silent	NA	T95T	0.16
LUAD	chr15	41050055	Silent	NA	L774L	0.15
LUAD	chr15	40980150	3'UTR	novel		0.52
LUAD	chr15	41020992	Missense_Mutation	novel	W1061L	0.08
LUAD	chr15	41069581	Missense_Mutation	NA	P591A	0.43	ResIII
LUAD	chr15	41085473	Missense_Mutation	rs774135495	D257N	0.08
LUSC	chr15	41079759	Missense_Mutation	NA	R358H	0.39
LUSC	chr15	40997581	Missense_Mutation	NA	L1173R	0.31
LUSC	chr15	41059910	Missense_Mutation	NA	G600V	0.25	ResIII
LUSC	chr15	40987106	Missense_Mutation	NA	E1273K	0.33
LUSC	chr15	41095618	Missense_Mutation	novel	S122G	0.11
LUSC	chr15	41055260	Silent	novel	S725S	0.35
LUSC	chr15	41045015	Missense_Mutation	novel	W932C	0.07
LUSC	chr15	41074412	Missense_Mutation	rs771768508	I429V	0.31
LUSC	chr15	41095768	Missense_Mutation	novel	L102V	0.4
LUSC	chr15	41016195	Missense_Mutation	NA	D1099N	0.17
LUSC	chr15	41085450	Missense_Mutation	NA	K264N	0.19
LUSC	chr15	40987842	Silent	NA	L1235L	0.05
LUSC	chr15	41096268	Missense_Mutation	NA	E15K	0.13
LUSC	chr15	40983047	Missense_Mutation	novel	G1423E	0.22
MESO	chr15	41085493	Missense_Mutation	novel	V250D	0.26
MESO	chr15	40984203	Silent	novel	F1357F	0.11
OV	chr15	41050097	Missense_Mutation	NA	E760D	0.54
OV	chr15	41092112	Missense_Mutation	rs145473172	N151S	0.13
OV	chr15	41049377	Missense_Mutation	novel	S829F	0.11
OV	chr15	40987135	Missense_Mutation	NA	E1263V	0.73
OV	chr15	41059897	Missense_Mutation	novel	D604E	0.09	ResIII
OV	chr15	40983862	Silent	NA	D1379D	0.37
PAAD	chr15	41049406	Silent	rs181458553	P819P	0.06
PAAD	chr15	40982920	Silent	rs758803693	A1465A	0.07
PAAD	chr15	41021044	Missense_Mutation	novel	L1044M	0.04
PRAD	chr15	40980321	Missense_Mutation	NA	P1525T	0.36
PRAD	chr15	41021016	Missense_Mutation	novel	G1053V	0.06
PRAD	chr15	41027614	Frame_Shift_Ins	novel	*L1010Ffs19**	0.16
PRAD	chr15	41092041	Missense_Mutation	rs762338137	S175R	0.24
READ	chr15	41050005	Missense_Mutation	novel	S791Y	0.47
READ	chr15	41055271	Missense_Mutation	novel	E722K	0.35
READ	chr15	41092079	Missense_Mutation	rs755595019	R162Q	0.39
READ	chr15	41096312	5'UTR	novel		0.41
READ	chr15	40984194	Splice_Region	novel		0.25
SARC	chr15	41074528	Missense_Mutation	novel	T390I	0.05
SARC	chr15	41027644	Silent	novel	R1000R	0.14
SARC	chr15	41096223	Silent	novel	R30R	0.07
SARC	chr15	40979571	3'UTR	novel		0.46
SKCM	chr15	41047450	Missense_Mutation	novel	P898L	0.3
SKCM	chr15	41085416	Missense_Mutation	novel	R276C	0.22
SKCM	chr15	41079820	Missense_Mutation	NA	R338G	0.38
SKCM	chr15	40984293	Silent	NA	I1327I	0.24
SKCM	chr15	40980357	Missense_Mutation	NA	P1513S	0.84
SKCM	chr15	40987822	In_Frame_Ins	novel	K1241_S1242insG	0.04
SKCM	chr15	41048256	Missense_Mutation	NA	P866L	0.12
SKCM	chr15	41045060	Silent	novel	F917F	0.26
SKCM	chr15	41056639	Nonsense_Mutation	NA	Q685*	0.42
SKCM	chr15	40987160	Missense_Mutation	novel	K1255E	0.64
SKCM	chr15	41073482	Silent	rs759826144	F447F	0.44
SKCM	chr15	41027625	Missense_Mutation	novel	P1007S	0.17
SKCM	chr15	40983883	Silent	NA	P1372P	0.48
SKCM	chr15	41096228	Missense_Mutation	NA	A28V	0.39
SKCM	chr15	41081049	Missense_Mutation	NA	R300C	0.16
SKCM	chr15	41079898	Missense_Mutation	rs780868252	H312Y	0.4
SKCM	chr15	41049362	Missense_Mutation	rs531473781	S834F	0.11
SKCM	chr15	41079828	Missense_Mutation	novel	R335P	0.21
SKCM	chr15	40983803	Missense_Mutation	novel	S1399F	0.34
SKCM	chr15	40980346	Silent	NA	S1516S	0.36
SKCM	chr15	40980346	Silent	NA	S1516S	0.15
SKCM	chr15	41085464	Missense_Mutation	NA	P260S	0.42
SKCM	chr15	41048257	Missense_Mutation	NA	P866S	0.38
SKCM	chr15	41085486	Silent	novel	A252A	0.27
SKCM	chr15	41085487	Missense_Mutation	novel	A252V	0.27
SKCM	chr15	40982921	Missense_Mutation	NA	A1465V	0.3
STAD	chr15	41085557	Frame_Shift_Del	NA	*R229Dfs45**	0.47
STAD	chr15	41074490	Nonsense_Mutation	NA	R403*	0.3
STAD	chr15	41095601	Splice_Region	NA	K127K	0.34
STAD	chr15	41085557	Frame_Shift_Del	NA	*R229Dfs45**	0.33
STAD	chr15	41095880	Silent	novel	Q64Q	0.18
STAD	chr15	41059889	Missense_Mutation	NA	V607G	0.11	ResIII
STAD	chr15	41096225	Missense_Mutation	NA	L29R	0.19
STAD	chr15	40982966	Missense_Mutation	NA	R1450Q	0.09
STAD	chr15	40984251	Silent	rs767154199	D1341D	0.15
STAD	chr15	41081024	Missense_Mutation	novel	R308Q	0.2
STAD	chr15	41054002	Missense_Mutation	rs768238241	R734H	0.1
STAD	chr15	41079822	Missense_Mutation	novel	R337H	0.31
STAD	chr15	41087616	Missense_Mutation	rs202070069	R202W	0.14
STAD	chr15	40984240	Missense_Mutation	NA	S1345F	0.34
STAD	chr15	41087570	Missense_Mutation	NA	K217R	0.18
STAD	chr15	40984295	Missense_Mutation	rs755098116	I1327V	0.25
TGCT	chr15	41016149	Missense_Mutation	novel	K1114T	0.15
UCEC	chr15	41070542	Silent	novel	I537I	0.1
UCEC	chr15	41079727	Missense_Mutation	novel	R369W	0.07
UCEC	chr15	41071924	Silent	NA	Q510Q	0.43
UCEC	chr15	40997549	Missense_Mutation	NA	N1184D	0.3
UCEC	chr15	40983842	Missense_Mutation	novel	D1386G	0.35
UCEC	chr15	41072025	Nonsense_Mutation	NA	R477*	0.44
UCEC	chr15	41056702	Missense_Mutation	NA	R664C	0.05	ResIII
UCEC	chr15	41005621	Nonsense_Mutation	novel	R1157*	0.38
UCEC	chr15	41058776	Silent	novel	T616T	0.37
UCEC	chr15	41069605	Missense_Mutation	novel	H583Y	0.4	ResIII
UCEC	chr15	41079760	Missense_Mutation	novel	R358C	0.32
UCEC	chr15	41074377	Missense_Mutation	NA	E440D	0.27
UCEC	chr15	40987109	Missense_Mutation	NA	E1272K	0.4
UCEC	chr15	41047479	Missense_Mutation	novel	F888L	0.1
UCEC	chr15	40979559	3'UTR	rs533192828		0.41
UCEC	chr15	40982920	Silent	rs758803693	A1465A	0.44
UCEC	chr15	41074416	Silent	rs574924831	I427I	0.21
UCEC	chr15	40979559	3'UTR	rs533192828		0.43
UCEC	chr15	40984279	Missense_Mutation	rs142469845	S1332L	0.34
UCEC	chr15	40983859	Missense_Mutation	NA	M1380I	0.2
UCEC	chr15	41020948	Missense_Mutation	NA	L1076M	0.19
UCEC	chr15	41073460	Missense_Mutation	NA	A455T	0.26
UCEC	chr15	41074377	Missense_Mutation	NA	E440D	0.26
UCEC	chr15	40979688	3'UTR	novel		0.54
UCEC	chr15	40982886	Missense_Mutation	rs753014093	A1477T	0.13
UCEC	chr15	40997569	Missense_Mutation	NA	R1177Q	0.31
UCEC	chr15	41027646	Missense_Mutation	rs149600837	R1000C	0.21
UCEC	chr15	41085457	Missense_Mutation	novel	G262D	0.16
UCEC	chr15	40984251	Silent	rs767154199	D1341D	0.11
UCEC	chr15	41047452	Silent	rs780492133	S897S	0.38
UCEC	chr15	40978982	3'UTR	novel		0.37
UCEC	chr15	40980105	3'UTR	novel		0.07
UCEC	chr15	41085492	Silent	novel	V250V	0.8
UCEC	chr15	41074432	Missense_Mutation	rs768979105	S422Y	0.31
UCEC	chr15	41087615	Missense_Mutation	rs748102914	R202Q	0.32
UCEC	chr15	41073450	Missense_Mutation	novel	A458D	0.31
UCEC	chr15	40980070	3'UTR	novel		0.31
UCEC	chr15	40984251	Silent	rs767154199	D1341D	0.47
UCEC	chr15	40987879	Silent	novel	Y1222Y	0.35
UCEC	chr15	41085518	Missense_Mutation	rs750659871	R242C	0.35
UCEC	chr15	41096301	Missense_Mutation	NA	E4Q	0.27
UCEC	chr15	41058744	Frame_Shift_Ins	novel	*V627Gfs27**	0.09	ResIII
UCEC	chr15	41073451	Missense_Mutation	novel	A458T	0.33
UCEC	chr15	40980416	Missense_Mutation	NA	Q1493R	0.43
UCEC	chr15	41071954	Silent	rs753829713	P500P	0.3
UCEC	chr15	41085557	Frame_Shift_Del	NA	*R229Dfs45**	0.14
UCEC	chr15	41085569	In_Frame_Del	novel	K224_V225delinsM	0.06
UCEC	chr15	41085476	Missense_Mutation	novel	H256N	0.39
UCEC	chr15	41020918	Missense_Mutation	novel	S1086P	0.49
UCEC	chr15	41055337	Missense_Mutation	novel	P700S	0.33
UCEC	chr15	41095826	Silent	novel	G82G	0.36
UCEC	chr15	40979643	3'UTR	novel		0.41
UCEC	chr15	40980160	3'UTR	novel		0.34
UCEC	chr15	41044904	Missense_Mutation	novel	K969N	0.44
UCEC	chr15	41027598	Nonsense_Mutation	NA	R1016*	0.51
UCEC	chr15	41079713	Missense_Mutation	novel	E373D	0.19
UCEC	chr15	40980320	Missense_Mutation	novel	P1525H	0.27
UCEC	chr15	40997547	Missense_Mutation	novel	N1184K	0.28
UCEC	chr15	41027645	Missense_Mutation	rs376025111	R1000H	0.1
UCEC	chr15	41056652	Silent	rs377374850	T680T	0.34
UCEC	chr15	40979075	3'UTR	novel		0.33
UCEC	chr15	40979533	3'UTR	novel		0.52
UCEC	chr15	40987828	Missense_Mutation	novel	K1239N	0.06
UCEC	chr15	40979479	3'UTR	novel		0.33
UCEC	chr15	40983900	Missense_Mutation	rs371610578	H1367Y	0.28
UCEC	chr15	41053929	Missense_Mutation	novel	K758N	0.22
UCEC	chr15	41095634	Silent	NA	F116F	0.42
UCEC	chr15	40983780	Missense_Mutation	rs753109209	V1407I	0.4
UCEC	chr15	41047469	Missense_Mutation	novel	R892C	0.44
UCEC	chr15	41049304	Silent	rs772156333	F853F	0.04
UCEC	chr15	41071914	Missense_Mutation	NA	F514V	0.51
UCEC	chr15	40985418	Missense_Mutation	NA	R1281W	0.35
UCEC	chr15	41005658	Silent	novel	Y1144Y	0.17
UCEC	chr15	41044934	Silent	novel	F959F	0.22
UCEC	chr15	41058696	Missense_Mutation	novel	R643Q	0.19	ResIII
UCEC	chr15	41079858	Missense_Mutation	novel	A325V	0.2
UCEC	chr15	41049294	Nonsense_Mutation	novel	R857*	0.05
UCEC	chr15	41055348	Missense_Mutation	NA	H696R	0.36
UCEC	chr15	41085520	Missense_Mutation	novel	P241H	0.42

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
ACC	DEL	0.2333	0.079424
CESC	DEL	0.2	0.00049652
COAD	DEL	0.3548	2.3878e-07
GBM	DEL	0.2132	3.453e-12
HNSC	DEL	0.1686	0.11567
KICH	AMP	0.2727	0.21756
KIRP	DEL	0.1111	0.2062
LUAD	DEL	0.3953	6.8561e-07
MESO	DEL	0.3103	4.5411e-10
PAAD	DEL	0.1359	0.13216
READ	DEL	0.4364	0.025797
SARC	DEL	0.2023	0.18974
UCEC	DEL	0.2412	7.1012e-08

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.0001	Kaplan-Meier Survival Analysis
SARC	0.013	Kaplan-Meier Survival Analysis
MESO	0.0012	Kaplan-Meier Survival Analysis
ACC	0.013	Kaplan-Meier Survival Analysis
SKCM	0.029	Kaplan-Meier Survival Analysis
READ	0.018	Kaplan-Meier Survival Analysis
UVM	0.03	Kaplan-Meier Survival Analysis
OV	0.017	Kaplan-Meier Survival Analysis

Description

RBDs

Expression

Transcripts

Gene Model

Phenotype

GWAS

PPI

Ortholog

Gene Ontology

Description

Ensembl ID: ENSG00000128908 (Gene tree)
Gene ID: 54617
Gene Symbol: INO80
Alias: KIAA1259|Ino80|hINO80|INO80A|INOC1
Full Name: INO80 complex subunit
Gene Type: protein_coding
Specie: Homo_sapiens
Strand: Minus strand
Length: 137,475 bases
Position: chr15:40,978,880-41,116,354
Accession: 26956
Summary: This gene encodes a subunit of the chromatin remodeling complex, which is classified into subfamilies depending on sequence features apart from the conserved ATPase domain. This protein is the catalytic ATPase subunit of the INO80 chromatin remodeling complex, which is characterized by a DNA-binding domain. This protein is proposed to bind DNA and be recruited by the YY1 transcription factor to activate certain genes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000355205	ResIII	PF04851.15	6.6e-05	1	1
ENSP00000384686	ResIII	PF04851.15	6.6e-05	1	1
ENSP00000497609	ResIII	PF04851.15	6.6e-05	1	1

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000401393	INO80-202	5991	XM_011521686	ENSP00000384686	1556 (aa)	XP_011519988	Q9ULG1
ENST00000616814	INO80-211	4272	-	ENSP00000483661	192 (aa)	-	A0A087X0U7
ENST00000560689	INO80-207	580	-	-	- (aa)	-	-
ENST00000560799	INO80-208	542	-	-	- (aa)	-	-
ENST00000561172	INO80-209	402	-	-	- (aa)	-	-
ENST00000557849	INO80-203	599	-	ENSP00000452806	27 (aa)	-	H0YKH3
ENST00000558270	INO80-204	888	-	-	- (aa)	-	-
ENST00000361937	INO80-201	6439	-	ENSP00000355205	1556 (aa)	-	Q9ULG1
ENST00000559995	INO80-206	2140	-	ENSP00000454057	91 (aa)	-	H0YNL3
ENST00000561244	INO80-210	493	-	-	- (aa)	-	-
ENST00000558357	INO80-205	6041	XM_011521685	ENSP00000453677	1104 (aa)	XP_011519987	H0YMN5
ENST00000648947	INO80-212	6365	-	ENSP00000497609	1556 (aa)	-	A0A024R9R7

Gene Model

Click here to download ENSG00000128908's gene model file

Phenotype

ensgID	Trait	pValue	Pubmed ID
ENSG00000128908	Hip	4.78662554092228E-6	17903296
ENSG00000128908	Bone Density	4.14136289064137E-7	17903296
ENSG00000128908	Hip	2.07172362118905E-10	17903296
ENSG00000128908	Occipital Lobe	2.68357731587451E-9	17903297
ENSG00000128908	Occipital Lobe	3.76315639704912E-9	17903297
ENSG00000128908	Platelet Function Tests	9.1800000E-006	-
ENSG00000128908	Platelet Function Tests	1.3632700E-005	-
ENSG00000128908	Platelet Function Tests	5.9766084E-007	-
ENSG00000128908	Platelet Function Tests	1.4229700E-005	-
ENSG00000128908	Platelet Function Tests	5.2251586E-007	-
ENSG00000128908	Platelet Function Tests	4.6536082E-007	-
ENSG00000128908	Platelet Function Tests	5.1845182E-006	-
ENSG00000128908	Creatinine	3E-8	26831199
ENSG00000128908	Glomerular Filtration Rate	3E-8	26831199
ENSG00000128908	Creatinine	9E-9	26831199
ENSG00000128908	Glomerular Filtration Rate	9E-9	26831199

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000128908	rs2928148	15	41109352	A	Glomerular filtration rate in non diabetics (creatinine)	26831199	[0.0032-0.0068] unit increase	0.005	EFO_0005208\|EFO_0004518
ENSG00000128908	rs476633	15	41099936	C	Glomerular filtration rate (creatinine)	26831199	[0.0033-0.0069] unit increase	0.0051	EFO_0005208\|EFO_0004518
ENSG00000128908	rs9796	15	40979249	T	Menopause (age at onset)	26414677	[0.091-0.169] years decrease	0.13	EFO_0004704
ENSG00000128908	rs6492982	15	41107753	?	Glomerular filtration rate (creatinine)	28452372			EFO_0005208\|EFO_0004518
ENSG00000128908	rs75322822	15	41064241	?	General cognitive ability	29844566	z-score decrease	4.996	EFO_0004337
ENSG00000128908	rs75322822	15	41064241	A	Intelligence	29942086	z-score decrease	5.593	EFO_0004337
ENSG00000128908	rs34153025	15	41047499	?	Body mass index	30595370			EFO_0004340
ENSG00000128908	rs2925343	15	41014295	?	Macular thickness	30535121	[0.25-0.54] unit decrease	0.394	EFO_0008375
ENSG00000128908	rs112925537	15	41042016	A	Diastolic blood pressure	27841878	unit decrease	0.204	EFO_0006336
ENSG00000128908	rs112925537	15	41042016	A	Systolic blood pressure	27841878	unit decrease	0.413	EFO_0006335
ENSG00000128908	rs112925537	15	41042016	A	Pulse pressure	27841878	unit decrease	0.204	EFO_0005763

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000128908's network

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy	Species
ENSG00000128908	INO80	99	69.495	ENSAPOG00000012586	ino80	99	69.939	Acanthochromis_polyacanthus
ENSG00000128908	INO80	100	99.419	ENSAMEG00000016796	INO80	100	98.206	Ailuropoda_melanoleuca
ENSG00000128908	INO80	90	84.831	ENSACIG00000001918	ino80	97	73.717	Amphilophus_citrinellus
ENSG00000128908	INO80	90	84.270	ENSAOCG00000000490	ino80	100	73.077	Amphiprion_ocellaris
ENSG00000128908	INO80	90	84.270	ENSAPEG00000022911	ino80	100	73.220	Amphiprion_percula
ENSG00000128908	INO80	90	84.270	ENSATEG00000001271	ino80	100	72.973	Anabas_testudineus
ENSG00000128908	INO80	100	90.647	ENSAPLG00000013656	INO80	100	90.775	Anas_platyrhynchos
ENSG00000128908	INO80	99	86.235	ENSACAG00000003531	INO80	99	88.654	Anolis_carolinensis
ENSG00000128908	INO80	100	98.909	ENSANAG00000032223	INO80	100	98.909	Aotus_nancymaae
ENSG00000128908	INO80	90	84.831	ENSACLG00000006610	ino80	99	71.561	Astatotilapia_calliptera
ENSG00000128908	INO80	100	97.126	ENSBTAG00000010380	INO80	100	97.126	Bos_taurus
ENSG00000128908	INO80	100	99.101	ENSCJAG00000020770	-	100	99.101	Callithrix_jacchus
ENSG00000128908	INO80	100	99.419	ENSCAFG00000009492	INO80	100	98.333	Canis_familiaris
ENSG00000128908	INO80	99	97.993	ENSCAFG00020005524	-	99	97.907	Canis_lupus_dingo
ENSG00000128908	INO80	100	98.837	ENSCHIG00000010246	INO80	100	97.309	Capra_hircus
ENSG00000128908	INO80	100	98.837	ENSTSYG00000003252	INO80	100	98.396	Carlito_syrichta
ENSG00000128908	INO80	100	97.433	ENSCPOG00000011386	INO80	100	97.433	Cavia_porcellus
ENSG00000128908	INO80	100	98.780	ENSCCAG00000030680	INO80	100	98.780	Cebus_capucinus
ENSG00000128908	INO80	100	100.000	ENSCATG00000040663	INO80	100	99.550	Cercocebus_atys
ENSG00000128908	INO80	100	97.625	ENSCLAG00000008397	INO80	100	97.625	Chinchilla_lanigera
ENSG00000128908	INO80	100	100.000	ENSCSAG00000007632	INO80	100	99.614	Chlorocebus_sabaeus
ENSG00000128908	INO80	72	93.701	ENSCHOG00000011938	INO80	77	97.633	Choloepus_hoffmanni
ENSG00000128908	INO80	100	91.095	ENSCPBG00000013491	INO80	100	91.095	Chrysemys_picta_bellii
ENSG00000128908	INO80	100	95.652	ENSCANG00000036208	INO80	100	92.802	Colobus_angolensis_palliatus
ENSG00000128908	INO80	100	98.837	ENSCGRG00001013566	Ino80	100	97.049	Cricetulus_griseus_chok1gshd
ENSG00000128908	INO80	100	98.837	ENSCGRG00000001290	Ino80	100	97.049	Cricetulus_griseus_crigri
ENSG00000128908	INO80	93	79.459	ENSCSEG00000019370	ino80	94	74.838	Cynoglossus_semilaevis
ENSG00000128908	INO80	90	82.022	ENSCVAG00000021470	ino80	97	74.269	Cyprinodon_variegatus
ENSG00000128908	INO80	90	87.356	ENSDARG00000070432	ino80	97	75.989	Danio_rerio
ENSG00000128908	INO80	100	97.819	ENSDNOG00000010267	INO80	100	97.819	Dasypus_novemcinctus
ENSG00000128908	INO80	77	71.233	ENSEBUG00000001921	ino80	96	66.472	Eptatretus_burgeri
ENSG00000128908	INO80	100	97.822	ENSEASG00005016405	INO80	100	97.822	Equus_asinus_asinus
ENSG00000128908	INO80	90	79.310	ENSELUG00000001071	ino80	96	73.292	Esox_lucius
ENSG00000128908	INO80	100	99.419	ENSFCAG00000014722	INO80	100	98.206	Felis_catus
ENSG00000128908	INO80	100	89.679	ENSFALG00000006125	INO80	100	89.936	Ficedula_albicollis
ENSG00000128908	INO80	99	97.433	ENSFDAG00000005624	INO80	99	97.433	Fukomys_damarensis
ENSG00000128908	INO80	85	75.459	ENSFHEG00000020436	ino80	88	75.459	Fundulus_heteroclitus
ENSG00000128908	INO80	99	68.153	ENSGMOG00000006031	ino80	99	71.675	Gadus_morhua
ENSG00000128908	INO80	100	90.391	ENSGALG00000008553	INO80	100	90.519	Gallus_gallus
ENSG00000128908	INO80	90	83.146	ENSGAFG00000006358	ino80	98	74.884	Gambusia_affinis
ENSG00000128908	INO80	90	80.682	ENSGACG00000012960	ino80	99	70.705	Gasterosteus_aculeatus
ENSG00000128908	INO80	99	90.237	ENSGAGG00000019203	INO80	99	91.745	Gopherus_agassizii
ENSG00000128908	INO80	93	83.243	ENSHBUG00000022614	ino80	99	73.959	Haplochromis_burtoni
ENSG00000128908	INO80	100	96.919	ENSHGLG00000018136	INO80	100	96.919	Heterocephalus_glaber_female
ENSG00000128908	INO80	100	96.598	ENSHGLG00100006571	INO80	100	96.598	Heterocephalus_glaber_male
ENSG00000128908	INO80	93	81.319	ENSHCOG00000002445	ino80	97	74.081	Hippocampus_comes
ENSG00000128908	INO80	90	86.857	ENSIPUG00000018905	ino80	97	74.458	Ictalurus_punctatus
ENSG00000128908	INO80	100	98.013	ENSSTOG00000000427	INO80	100	98.013	Ictidomys_tridecemlineatus
ENSG00000128908	INO80	99	93.443	ENSJJAG00000016166	Ino80	100	91.784	Jaculus_jaculus
ENSG00000128908	INO80	90	83.708	ENSKMAG00000019273	ino80	99	72.673	Kryptolebias_marmoratus
ENSG00000128908	INO80	99	69.251	ENSLBEG00000024288	ino80	98	72.245	Labrus_bergylta
ENSG00000128908	INO80	90	92.442	ENSLACG00000008666	INO80	98	75.149	Latimeria_chalumnae
ENSG00000128908	INO80	90	92.442	ENSLOCG00000012304	ino80	100	78.489	Lepisosteus_oculatus
ENSG00000128908	INO80	100	97.561	ENSLAFG00000009951	INO80	100	97.561	Loxodonta_africana
ENSG00000128908	INO80	100	100.000	ENSMFAG00000044488	INO80	100	99.679	Macaca_fascicularis
ENSG00000128908	INO80	100	100.000	ENSMMUG00000001737	INO80	100	99.728	Macaca_mulatta
ENSG00000128908	INO80	100	100.000	ENSMNEG00000034906	INO80	100	99.422	Macaca_nemestrina
ENSG00000128908	INO80	100	100.000	ENSMLEG00000042117	INO80	100	99.679	Mandrillus_leucophaeus
ENSG00000128908	INO80	99	66.278	ENSMAMG00000013786	ino80	99	66.457	Mastacembelus_armatus
ENSG00000128908	INO80	90	84.831	ENSMZEG00005013146	ino80	99	73.942	Maylandia_zebra
ENSG00000128908	INO80	99	90.693	ENSMGAG00000011164	INO80	99	91.871	Meleagris_gallopavo
ENSG00000128908	INO80	100	98.837	ENSMAUG00000020670	Ino80	100	95.702	Mesocricetus_auratus
ENSG00000128908	INO80	100	97.563	ENSMICG00000005801	INO80	100	97.563	Microcebus_murinus
ENSG00000128908	INO80	100	98.837	ENSMOCG00000016879	Ino80	100	97.114	Microtus_ochrogaster
ENSG00000128908	INO80	99	66.038	ENSMMOG00000015046	ino80	99	66.244	Mola_mola
ENSG00000128908	INO80	100	94.740	ENSMODG00000000184	INO80	100	94.740	Monodelphis_domestica
ENSG00000128908	INO80	90	84.270	ENSMALG00000016488	ino80	99	72.955	Monopterus_albus
ENSG00000128908	INO80	100	98.256	MGP_CAROLIEiJ_G0024144	Ino80	100	93.711	Mus_caroli
ENSG00000128908	INO80	100	98.837	ENSMUSG00000034154	Ino80	100	96.857	Mus_musculus
ENSG00000128908	INO80	100	98.837	MGP_PahariEiJ_G0025587	Ino80	100	96.793	Mus_pahari
ENSG00000128908	INO80	100	98.256	MGP_SPRETEiJ_G0025060	Ino80	100	96.793	Mus_spretus
ENSG00000128908	INO80	100	99.419	ENSMPUG00000008786	INO80	100	98.270	Mustela_putorius_furo
ENSG00000128908	INO80	100	98.837	ENSMLUG00000017764	INO80	100	97.385	Myotis_lucifugus
ENSG00000128908	INO80	100	97.055	ENSNGAG00000019497	Ino80	100	97.055	Nannospalax_galili
ENSG00000128908	INO80	90	84.831	ENSNBRG00000022086	ino80	99	69.525	Neolamprologus_brichardi
ENSG00000128908	INO80	100	100.000	ENSNLEG00000003454	INO80	100	97.494	Nomascus_leucogenys
ENSG00000128908	INO80	99	75.523	ENSOPRG00000000831	INO80	91	79.235	Ochotona_princeps
ENSG00000128908	INO80	100	97.178	ENSODEG00000016734	INO80	100	97.178	Octodon_degus
ENSG00000128908	INO80	90	84.831	ENSONIG00000000772	ino80	99	73.524	Oreochromis_niloticus
ENSG00000128908	INO80	100	98.256	ENSOCUG00000010763	INO80	100	97.819	Oryctolagus_cuniculus
ENSG00000128908	INO80	90	84.091	ENSORLG00000018028	ino80	98	72.157	Oryzias_latipes
ENSG00000128908	INO80	90	84.091	ENSORLG00015012507	ino80	98	72.222	Oryzias_latipes_hsok
ENSG00000128908	INO80	90	84.091	ENSOMEG00000003791	ino80	97	72.313	Oryzias_melastigma
ENSG00000128908	INO80	100	98.837	ENSOGAG00000008998	INO80	100	98.267	Otolemur_garnettii
ENSG00000128908	INO80	100	98.837	ENSOARG00000020323	INO80	100	97.125	Ovis_aries
ENSG00000128908	INO80	100	100.000	ENSPPAG00000042104	INO80	100	99.871	Pan_paniscus
ENSG00000128908	INO80	100	99.419	ENSPPRG00000011011	INO80	100	98.206	Panthera_pardus
ENSG00000128908	INO80	100	99.419	ENSPTIG00000005911	INO80	100	97.950	Panthera_tigris_altaica
ENSG00000128908	INO80	100	100.000	ENSPTRG00000006939	INO80	100	99.936	Pan_troglodytes
ENSG00000128908	INO80	100	100.000	ENSPANG00000019131	INO80	100	99.679	Papio_anubis
ENSG00000128908	INO80	90	89.655	ENSPKIG00000021450	ino80	98	75.746	Paramormyrops_kingsleyae
ENSG00000128908	INO80	100	89.949	ENSPSIG00000014403	INO80	100	90.269	Pelodiscus_sinensis
ENSG00000128908	INO80	99	96.909	ENSPEMG00000013114	-	100	97.276	Peromyscus_maniculatus_bairdii
ENSG00000128908	INO80	100	94.676	ENSPCIG00000027848	INO80	100	94.676	Phascolarctos_cinereus
ENSG00000128908	INO80	97	72.733	ENSPFOG00000013082	ino80	99	71.909	Poecilia_formosa
ENSG00000128908	INO80	85	74.710	ENSPMEG00000021422	ino80	87	74.710	Poecilia_mexicana
ENSG00000128908	INO80	90	83.708	ENSPREG00000013650	ino80	95	74.051	Poecilia_reticulata
ENSG00000128908	INO80	99	100.000	ENSPPYG00000006368	INO80	99	97.163	Pongo_abelii
ENSG00000128908	INO80	100	98.837	ENSPCOG00000022332	INO80	100	96.727	Propithecus_coquereli
ENSG00000128908	INO80	100	98.837	ENSPVAG00000001852	INO80	100	95.697	Pteropus_vampyrus
ENSG00000128908	INO80	90	84.831	ENSPNYG00000002995	ino80	99	71.448	Pundamilia_nyererei
ENSG00000128908	INO80	99	79.208	ENSPNAG00000010386	ino80	100	75.287	Pygocentrus_nattereri
ENSG00000128908	INO80	100	96.665	ENSRNOG00000014483	Ino80	100	96.665	Rattus_norvegicus
ENSG00000128908	INO80	100	100.000	ENSRBIG00000031765	INO80	100	99.550	Rhinopithecus_bieti
ENSG00000128908	INO80	100	100.000	ENSRROG00000033143	INO80	100	99.614	Rhinopithecus_roxellana
ENSG00000128908	INO80	97	98.095	ENSSBOG00000023493	INO80	100	98.095	Saimiri_boliviensis_boliviensis
ENSG00000128908	INO80	100	94.676	ENSSHAG00000016349	INO80	100	94.676	Sarcophilus_harrisii
ENSG00000128908	INO80	90	87.356	ENSSFOG00015000183	ino80	99	76.653	Scleropages_formosus
ENSG00000128908	INO80	90	82.584	ENSSMAG00000007221	ino80	100	74.556	Scophthalmus_maximus
ENSG00000128908	INO80	90	83.708	ENSSDUG00000009957	ino80	100	73.304	Seriola_dumerili
ENSG00000128908	INO80	93	82.162	ENSSLDG00000000389	ino80	100	68.605	Seriola_lalandi_dorsalis
ENSG00000128908	INO80	100	95.930	ENSSARG00000007876	INO80	99	94.491	Sorex_araneus
ENSG00000128908	INO80	90	84.270	ENSSPAG00000007779	ino80	98	72.174	Stegastes_partitus
ENSG00000128908	INO80	100	98.837	ENSSSCG00000004753	INO80	100	97.573	Sus_scrofa
ENSG00000128908	INO80	100	89.302	ENSTGUG00000010786	INO80	100	89.558	Taeniopygia_guttata
ENSG00000128908	INO80	97	75.758	ENSTRUG00000013026	ino80	97	74.220	Takifugu_rubripes
ENSG00000128908	INO80	100	99.419	ENSTTRG00000011479	INO80	100	96.339	Tursiops_truncatus
ENSG00000128908	INO80	99	97.816	ENSUMAG00000012190	-	99	97.548	Ursus_maritimus
ENSG00000128908	INO80	99	92.707	ENSVPAG00000002838	INO80	100	91.651	Vicugna_pacos
ENSG00000128908	INO80	100	99.419	ENSVVUG00000026698	INO80	100	98.397	Vulpes_vulpes
ENSG00000128908	INO80	97	84.184	ENSXETG00000034272	INO80	99	73.684	Xenopus_tropicalis
ENSG00000128908	INO80	90	83.146	ENSXMAG00000006742	ino80	98	74.433	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000070	mitotic sister chromatid segregation	20237820.	IMP	Process
GO:0000724	double-strand break repair via homologous recombination	18026119.	IMP	Process
GO:0003677	DNA binding	16298340.	IDA	Function
GO:0003779	actin binding	-	IEA	Function
GO:0005515	protein binding	18026119.19014934.20855601.26496610.27705803.29643506.	IPI	Function
GO:0005524	ATP binding	-	IEA	Function
GO:0005634	nucleus	16298340.18026119.	IDA	Component
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005737	cytoplasm	-	IEA	Component
GO:0005819	spindle	-	IEA	Component
GO:0005874	microtubule	-	IEA	Component
GO:0005886	plasma membrane	-	IDA	Component
GO:0006281	DNA repair	21873635.	IBA	Process
GO:0006302	double-strand break repair	20687897.	IMP	Process
GO:0006338	chromatin remodeling	21873635.	IBA	Process
GO:0006338	chromatin remodeling	-	ISS	Process
GO:0006351	transcription, DNA-templated	-	IEA	Process
GO:0008094	DNA-dependent ATPase activity	16298340.	IDA	Function
GO:0010571	positive regulation of nuclear cell cycle DNA replication	20237820.	IMP	Process
GO:0016579	protein deubiquitination	-	TAS	Process
GO:0016604	nuclear body	-	IDA	Component
GO:0016887	ATPase activity	21873635.	IBA	Function
GO:0030307	positive regulation of cell growth	20237820.	IMP	Process
GO:0031011	Ino80 complex	21873635.	IBA	Component
GO:0031011	Ino80 complex	18026119.21303910.	IDA	Component
GO:0032508	DNA duplex unwinding	-	IEA	Process
GO:0034644	cellular response to UV	18026119.	IMP	Process
GO:0042393	histone binding	21873635.	IBA	Function
GO:0042766	nucleosome mobilization	21873635.	IBA	Process
GO:0043014	alpha-tubulin binding	20237820.	IMP	Function
GO:0043044	ATP-dependent chromatin remodeling	21873635.	IBA	Process
GO:0043140	ATP-dependent 3'-5' DNA helicase activity	21873635.	IBA	Function
GO:0043618	regulation of transcription from RNA polymerase II promoter in response to stress	21873635.	IBA	Process
GO:0045111	intermediate filament cytoskeleton	-	IDA	Component
GO:0045944	positive regulation of transcription by RNA polymerase II	20687897.	IMP	Process
GO:0051225	spindle assembly	20237820.	IMP	Process
GO:0051301	cell division	-	IEA	Process
GO:0070914	UV-damage excision repair	20855601.	IMP	Process
GO:0071479	cellular response to ionizing radiation	20687897.	IMP	Process
GO:2000045	regulation of G1/S transition of mitotic cell cycle	20237820.	IMP	Process

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