EuRBPDB

  • Home
  • Cancer
  • Family
  • Species
  • RBPredictor
  • Search
  • Download
  • Submit
  • Help
  • Contact
TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
22025453Expression levels of the microRNA maturing microprocessor complex component DGCR8 and the RNA-induced silencing complex (RISC) components argonaute-1, argonaute-2, PACT, TARBP1, and TARBP2 in epithelial skin cancer.Mol Carcinog2012 NovSand Mdoi: 10.1002/mc.20861
25823356Silencing the double-stranded RNA binding protein DGCR8 inhibits ovarian cancer cell proliferation, migration, and invasion.Pharm Res2015 MarGuo Y-
23629745Evaluation of genetic variants in microRNA biosynthesis genes and risk of breast cancer in Chinese women.Int J Cancer2013 NovJiang Ydoi: 10.1002/ijc.28237
28155978Evaluation of polymorphisms in microRNA biosynthesis genes and risk of laryngeal cancer in the Polish population.Pol J Pathol2016Bruzgielewicz Adoi: 10.5114/pjp.2016.63781.

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
ACCchr2220092855SilentnovelV551V0.06
ACCchr2220086222Missense_MutationnovelI87V0.14
BLCAchr2220094755Frame_Shift_DelnovelQ583Hfs*30.07
BLCAchr2220089755Missense_MutationnovelE323Q0.07
BLCAchr2220086230SilentNAP89P0.12
BLCAchr2220086646Missense_MutationNAD228G0.12
BLCAchr2220086494Missense_MutationNAE177D0.12
BLCAchr2220086164SilentNAF67F0.46
BLCAchr2220091561Missense_MutationnovelS478Y0.07
BLCAchr2220086564Missense_MutationnovelE201Q0.1
BLCAchr2220086438Missense_MutationnovelV159M0.29
BLCAchr2220086586Missense_MutationNAN208S0.73
BRCAchr2220086261Missense_MutationNAR100W0.14
BRCAchr22201101773'UTRnovel0.12
BRCAchr2220086228Missense_MutationnovelP89T0.1
BRCAchr2220086338Silentrs372483452T125T0.1
BRCAchr2220089891Intronnovel0.23
BRCAchr2220085979Missense_MutationnovelS6C0.18
BRCAchr2220091960Missense_Mutationrs758875827F532L0.17
BRCAchr2220091578Missense_MutationnovelP484A0.16
BRCAchr2220086526Missense_MutationNAL188R0.5
CESCchr2220091595SilentNAL489L0.32
CESCchr2220086597Missense_MutationNAD212H0.24
CESCchr2220106244Missense_MutationNAS619F0.33dsrm
CESCchr2220086369Missense_MutationnovelL136M0.34
CESCchr2220091889Missense_MutationnovelG509R0.42
CESCchr2220089919Intronnovel0.28
CESCchr2220089983Missense_MutationnovelD344G0.36
COADchr2220092909Splice_SitenovelX569_splice0.14
COADchr2220106661Silentrs763037264Y653Y0.45
COADchr2220089795Missense_MutationnovelG336E0.3
COADchr2220106215Silentrs145970507Y609Y0.21
COADchr2220086048Missense_MutationNAA29S0.36
COADchr2220086431SilentNAS156S0.12
COADchr22201102383'UTRnovel0.67
COADchr2220091449Nonsense_MutationNAR441*0.44
COADchr2220092844Missense_MutationnovelI548V0.31
COADchr2220091470Missense_MutationNAF448L0.46
COADchr2220087266Silentrs753194485S275S0.35
COADchr2220087253Missense_MutationnovelS271N0.06
COADchr2220090182Frame_Shift_DelnovelL411Gfs*190.36
COADchr2220086289Frame_Shift_DelnovelP110Lfs*90.22
COADchr2220086614Silentrs758334658G217G0.23
COADchr2220091877Missense_MutationnovelI505V0.48
DLBCchr2220089809Missense_MutationnovelR341W0.45
DLBCchr2220085989Missense_Mutationrs757595892P9L0.1
DLBCchr2220091551Nonsense_MutationnovelQ475*0.5
ESCAchr2220090190Missense_MutationnovelA413V0.22
GBMchr22200858655'UTRrs7769728560.42
GBMchr2220090104Frame_Shift_InsnovelS385Vfs*100.07
GBMchr2220087179Frame_Shift_DelnovelD246Efs*390.15
GBMchr2220086672Missense_MutationnovelF237V0.1
GBMchr2220091563Missense_MutationnovelE479K0.69
GBMchr2220089707Missense_MutationnovelW307R0.08
HNSCchr2220086600Missense_MutationnovelE213K0.26
HNSCchr2220087261Missense_MutationnovelP274S0.06
HNSCchr2220087177Missense_MutationnovelD246Y0.23
HNSCchr2220107342Missense_MutationnovelN690D0.05
KIRCchr2220091964Nonsense_MutationnovelE534*0.33
KIRPchr2220089952Intronnovel0.51
KIRPchr2220090259Splice_SiteNAX436_splice0.45
LGGchr2220086247Missense_MutationnovelS95I0.27
LGGchr2220091518Missense_MutationNAR464W0.34
LGGchr22200859575'UTRnovel0.5
LIHCchr2220086486Frame_Shift_DelnovelG176Vfs*270.32
LUADchr2220106264Nonsense_MutationNAE626*0.19dsrm
LUADchr2220089702Missense_MutationnovelD305V0.18
LUADchr2220086069Missense_MutationnovelP36S0.09
LUADchr2220091547SilentnovelR473R0.04
LUADchr2220107314SilentnovelI680I0.06
LUADchr2220106638Missense_MutationnovelG646W0.25dsrm
LUADchr22200858005'UTRnovel0.11
LUADchr2220090085Missense_MutationnovelP378H0.13
LUADchr2220091890Missense_MutationnovelG509V0.41
LUADchr2220090132Missense_MutationnovelE394K0.13
LUADchr2220091960Missense_MutationnovelF532L0.31
LUADchr2220092881Missense_MutationNAS560I0.48
LUADchr2220087290Silentrs745909755P283P0.12
LUSCchr2220091617Missense_MutationNAA497T0.54
LUSCchr2220089848Intronnovel0.54
LUSCchr2220107373Missense_MutationNAR700L0.24
LUSCchr2220094735Silentrs777754452L576L0.14
LUSCchr22201101663'UTRnovel0.31
LUSCchr2220086114Missense_MutationnovelV51F0.37
LUSCchr2220106615Missense_MutationnovelS638F0.27dsrm
LUSCchr2220090254SilentnovelS434S0.3
LUSCchr2220089888Intronnovel0.43
LUSCchr2220085990SilentnovelP9P0.07
LUSCchr2220092881Missense_MutationNAS560I0.32
LUSCchr2220086279SilentnovelR106R0.24
OVchr2220086215SilentnovelR84R0.14
OVchr2220086054Missense_MutationnovelP31S0.26
OVchr2220086056SilentnovelP31P0.25
OVchr2220090188SilentnovelG412G0.1
OVchr2220106177Missense_MutationnovelY597D0.17dsrm
OVchr2220091922Missense_MutationnovelM520V0.05
OVchr2220106263Missense_MutationnovelH625Q0.2dsrm
OVchr2220086468Frame_Shift_DelnovelD170Rfs*50.15
OVchr2220089871Intronnovel0.06
OVchr2220091499Missense_MutationnovelK457N0.04
PAADchr22200858545'UTRnovel0.05
PAADchr2220086173Silentrs778890073Y70Y0.2
PAADchr2220087289Missense_MutationnovelP283L0.17
PAADchr2220106669Missense_MutationnovelA656V0.14
PCPGchr22200857595'UTRnovel0.33
PRADchr2220085989Missense_Mutationrs757595892P9L0.12
PRADchr22200858935'UTRnovel0.05
READchr2220089715Missense_MutationNAM309I0.43
SARCchr2220090171Missense_Mutationrs200010909E407K0.26
SKCMchr2220086657Missense_MutationnovelE232K0.33
SKCMchr2220086416SilentnovelL151L0.18
SKCMchr2220086417Missense_MutationnovelL152F0.18
SKCMchr2220085994Missense_MutationNAP11S0.35
SKCMchr2220086671Missense_MutationNAN236K0.04
SKCMchr2220091601SilentNAT491T0.04
SKCMchr2220090072Missense_MutationnovelG374W0.47
SKCMchr2220086451Missense_Mutationrs767022640P163L0.33
SKCMchr2220092829Missense_MutationnovelG543S0.37
SKCMchr2220092830Missense_MutationnovelG543D0.37
SKCMchr2220086146Silentrs567813359L61L0.24
SKCMchr2220086664Missense_MutationnovelA234V0.19
SKCMchr2220086665SilentnovelA234A0.19
SKCMchr2220086186Missense_MutationNAL75F0.35
SKCMchr2220086674SilentNAF237F0.07
SKCMchr2220108958SilentNAI731I0.29
SKCMchr2220109003Splice_Regionrs376922099R746R0.45
SKCMchr2220086635Silentrs139146240I224I0.05
SKCMchr2220090163Missense_MutationnovelP404L0.44
SKCMchr2220086430Missense_MutationNAS156N0.47
SKCMchr2220106626Missense_MutationNAE642Q0.33dsrm
SKCMchr2220091962Missense_MutationnovelF533Y0.5
SKCMchr2220089925Intronnovel0.67
STADchr2220107361Missense_MutationNAR696H0.34
STADchr2220106669Missense_MutationnovelA656E0.11
STADchr2220107345Frame_Shift_InsNAS693Vfs*90.2
STADchr2220086408Missense_MutationNAG149C0.29
STADchr2220091943Missense_MutationNAR527C0.23
STADchr2220091593Missense_MutationnovelL489I0.37
STADchr2220086400Missense_Mutationrs201293912A146V0.27
STADchr2220086114Missense_MutationNAV51I0.33
STADchr2220091555Missense_MutationNAA476V0.29
STADchr2220107373Frame_Shift_DelnovelR700Lfs*160.16
STADchr2220108997Missense_MutationNAE744D0.3
STADchr22200858805'UTRrs7617877830.13
STADchr2220110063Silentrs765113050A759A0.19
STADchr2220110022Splice_Regionrs7645204680.3
STADchr2220089672Missense_Mutationrs759142349R295H0.08
STADchr2220086086SilentnovelQ41Q0.12
STADchr2220086390Missense_MutationNAD143N0.09
STADchr22201101383'UTRnovel0.44
THCAchr2220091916Missense_MutationNAE518K0.77
THCAchr2220091916Missense_MutationNAE518K0.57
UCECchr2220090087Missense_Mutationrs778778919V379I0.3
UCECchr2220091595SilentNAL489L0.2
UCECchr2220086247Missense_MutationnovelS95N0.41
UCECchr2220091560Missense_MutationnovelS478P0.47
UCECchr2220091869Missense_MutationnovelE502A0.19
UCECchr2220089906Intronnovel0.17
UCECchr2220094728Missense_MutationnovelE574A0.09
UCECchr2220090173Missense_MutationnovelE407D1
UCECchr22201104123'UTRnovel0.08
UCECchr2220106263Silentrs200794810H625H0.5
UCECchr2220107270Splice_SitenovelX666_splice0.34
UCECchr2220108898SilentNAS711S0.27
UCECchr2220091513Missense_MutationNAA462V0.39
UCECchr22200859555'UTRrs2021101200.36
UCECchr2220086349Missense_MutationnovelR129K0.4
UCECchr22200857855'UTRnovel0.23
UCECchr2220085990SilentnovelP9P0.38
UCECchr22201105163'UTRnovel0.29
UCECchr2220110034Nonsense_MutationNAR750*0.19
UCECchr2220086311Missense_MutationnovelK116N0.24
UCECchr2220086387Missense_Mutationrs547571792R142C0.16
UCECchr2220092865Missense_MutationNAS555P0.46
UCECchr22201104553'UTRrs7793810870.32
UCECchr2220086474Missense_MutationnovelG171R0.37
UCECchr2220089913Intronnovel0.26
UCECchr2220086229Missense_MutationnovelP89L0.39
UCECchr2220086110Missense_MutationnovelM49I0.44
UCECchr2220086088Missense_MutationNAT42M0.38
UCECchr2220087290Silentrs745909755P283P0.41
UCECchr22201111223'UTRnovel0.36
UCECchr22201109113'UTRnovel0.36
UCECchr2220094716Missense_MutationNAR570Q0.52
UCECchr22200857285'UTRrs7767877990.15
UCECchr2220087209SilentnovelC256C0.39
UCECchr2220106197SilentnovelI603I0.26
UCECchr2220086326Silentrs755427841S121S0.2
UCECchr22201109083'UTRnovel0.27
UCECchr2220091453Missense_MutationnovelS442I0.26
UCECchr22201105703'UTRnovel0.17
UCECchr22201102863'UTRnovel0.36
UCECchr2220094756SilentnovelQ583Q0.43
UCECchr2220106591Splice_SitenovelX630_splice0.4
UCECchr2220091439Silentrs752529619L437L0.34
UCECchr2220090211Missense_MutationNAL420P0.22
UCECchr2220110036SilentnovelR750R0.08
UCECchr2220086191SilentnovelS76S0.21
UCECchr2220091518Missense_MutationNAR464W0.29
UCECchr2220086489Missense_Mutationrs541503891G176S0.29
UCECchr2220086393Missense_Mutationrs761204926V144M0.38
UCECchr22201105413'UTRnovel0.47
UCECchr22201101123'UTRrs7453205530.33
UCECchr2220086088Missense_MutationNAT42M0.32
UCECchr2220094716Missense_MutationNAR570Q0.32
UCECchr2220086407Silentrs138332207C148C0.55
UCECchr2220086006Missense_Mutationrs140782334A15T0.42
UCECchr2220086573Missense_MutationnovelD204Y0.21
UCECchr2220087226Missense_MutationnovelR262Q0.24
UCECchr2220106661Nonsense_MutationnovelY653*0.38
UCECchr2220086006Missense_Mutationrs140782334A15T0.23
UCECchr2220106692Missense_MutationnovelG664R0.3
UCECchr2220091449Nonsense_MutationNAR441*0.32
UCSchr2220086561Missense_MutationnovelD200N0.32

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
LUSCAMP0.38922.9109e-05
LUSCDEL0.11780.0093511
TGCTAMP0.35335.309e-06
THCAAMP0.0080.056221

Survival Analysis
CancerP-value Q-value
THYM0.0011

Kaplan-Meier Survival Analysis

KIRC0.0014

Kaplan-Meier Survival Analysis

STAD0.0047

Kaplan-Meier Survival Analysis

SARC0.017

Kaplan-Meier Survival Analysis

ACC0.00012

Kaplan-Meier Survival Analysis

HNSC0.0045

Kaplan-Meier Survival Analysis

SKCM0.0018

Kaplan-Meier Survival Analysis

ESCA0.0068

Kaplan-Meier Survival Analysis

PAAD0.0039

Kaplan-Meier Survival Analysis

BLCA0.017

Kaplan-Meier Survival Analysis

READ0.012

Kaplan-Meier Survival Analysis

LIHC0.01

Kaplan-Meier Survival Analysis

LGG0.0061

Kaplan-Meier Survival Analysis

THCA0.024

Kaplan-Meier Survival Analysis

Drugs

Select Dataset :


Input Drug :


Input Cell Line :


Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBDs
  • RBPome
  • PRI
  • Literatures
  • Expression
  • Transcripts
  • Gene Model
  • GWAS
  • PPI
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000128191 (Gene tree)
Gene ID
54487
Gene Symbol
DGCR8
Alias
DGCRK6|Gy1|pasha|C22orf12
Full Name
DGCR8 microprocessor complex subunit
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Plus strand
Length
31,646 bases
Position
chr22:20,080,232-20,111,877
Accession
2847
RBP type
canonical RBP
Summary
This gene encodes a subunit of the microprocessor complex which mediates the biogenesis of microRNAs from the primary microRNA transcript. The encoded protein is a double-stranded RNA binding protein that functions as the non-catalytic subunit of the microprocessor complex. This protein is required for binding the double-stranded RNA substrate and facilitates cleavage of the RNA by the ribonuclease III protein, Drosha. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jun 2010]
RNA binding domains(RBDs)
Protein IDDomain Pfam IDE-value Domain number Total number
ENSP00000263209dsrmPF00035.264e-2012
ENSP00000263209dsrmPF00035.264e-2022
ENSP00000372488dsrmPF00035.266.8e-0511
ENSP00000384726dsrmPF00035.266.8e-0511
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & HEK2932019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
Protein-RNA interaction(RNA-Binding Site)
Click here to download all RNA binding sites
Click here to download all RNA binding sites
Click here to download all RNA binding sites

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
24954387'Black sheep' that don't leave the double-stranded RNA-binding domain fold.Trends Biochem Sci2014 JulGleghorn MLdoi: 10.1016/j.tibs.2014.05.003
23776147Processing of virus-derived cytoplasmic primary-microRNAs.Wiley Interdiscip Rev RNA2013 Jul-AugShapiro JSdoi: 10.1002/wrna.1169
23893406The core microprocessor component DiGeorge syndrome critical region 8 (DGCR8) is a nonspecific RNA-binding protein.J Biol Chem2013 Sep 13Roth BMdoi: 10.1074/jbc.M112.446880
23637774miRNA biogenesis enzyme Drosha is required for vascular smooth muscle cell survival.PLoS One2013 Apr 18Fan Pdoi: 10.1371/journal.pone.0060888
23478018Sequestration of DROSHA and DGCR8 by expanded CGG RNA repeats alters microRNA processing in fragile X-associated tremor/ataxia syndrome.Cell Rep2013 Mar 28Sellier Cdoi: 10.1016/j.celrep.2013.02.004
30285465Sepiapterin alleviates impaired gastric nNOS function in spontaneous diabetic female rodents through NRF2 mRNA turnover and miRNA biogenesis pathway.Am J Physiol Gastrointest Liver Physiol2018 Dec 1Gangula PRdoi: 10.1152/ajpgi.00152.2018
17159994Heme is involved in microRNA processing.Nat Struct Mol Biol2007 JanFaller M-
24910438The DGCR8 RNA-binding heme domain recognizes primary microRNAs by clamping the hairpin.Cell Rep2014 Jun 26Quick-Cleveland Jdoi: 10.1016/j.celrep.2014.05.013
26027739Functional Anatomy of the Human Microprocessor.Cell2015 Jun 4Nguyen TAdoi: 10.1016/j.cell.2015.05.010
28380355DGCR8 Mediates Repair of UV-Induced DNA Damage Independently of RNA Processing.Cell Rep2017 Apr 4Calses PCdoi: 10.1016/j.celrep.2017.03.021.
15531877The Microprocessor complex mediates the genesis of microRNAs.Nature2004 Nov 11Gregory RI-
15531879Processing of primary microRNAs by the Microprocessor complex.Nature2004 Nov 11Denli AM-
20116247MicroRNA function is globally suppressed in mouse oocytes and early embryos.Curr Biol2010 Feb 9Suh Ndoi: 10.1016/j.cub.2009.12.044
19759829Genomic analysis suggests that mRNA destabilization by the microprocessor is specialized for the auto-regulation of Dgcr8.PLoS One2009 Sep 11Shenoy Adoi: 10.1371/journal.pone.0006971.
19383765Post-transcriptional control of DGCR8 expression by the Microprocessor.RNA2009 JunTriboulet Rdoi: 10.1261/rna.1591709
19301657Protein components of the microRNA pathway and human diseases.Methods Mol Biol2009Perron MPdoi: 10.1007/978-1-60327-547-7_18.
19223442Genome-wide identification of targets of the drosha-pasha/DGCR8 complex.RNA2009 AprKadener Sdoi: 10.1261/rna.1319309
19047376A Drosophila pasha mutant distinguishes the canonical microRNA and mirtron pathways.Mol Cell Biol2009 FebMartin Rdoi: 10.1128/MCB.01524-08
18684997Frequency and fate of microRNA editing in human brain.Nucleic Acids Res2008 SepKawahara Ydoi: 10.1093/nar/gkn479
18469815Altered brain microRNA biogenesis contributes to phenotypic deficits in a 22q11-deletion mouse model.Nat Genet2008 JunStark KLdoi: 10.1038/ng.138
17259983DGCR8 is essential for microRNA biogenesis and silencing of embryonic stem cell self-renewal.Nat Genet2007 MarWang Y-
22752847Backbone 1HN, 13C, and 1N resonance assignments of the tandem RNA-binding domains of human DGCR8.Biomol NMR Assign2013 OctRoth BMdoi: 10.1007/s12104-012-9406-x
22511778DiGeorge syndrome critical region 8 (DGCR8) protein-mediated microRNA biogenesis is essential for vascular smooth muscle cell development in mice.J Biol Chem2012 Jun 1Chen Zdoi: 10.1074/jbc.M112.351791
22308374Ferric, not ferrous, heme activates RNA-binding protein DGCR8 for primary microRNA processing.Proc Natl Acad Sci U S A2012 Feb 7Barr Idoi: 10.1073/pnas.1114514109
22222205Histone deacetylase 1 enhances microRNA processing via deacetylation of DGCR8.EMBO Rep2012 Feb 1Wada Tdoi: 10.1038/embor.2011.247.
22138056Dgcr8 controls neural crest cells survival in cardiovascular development.Dev Biol2012 Feb 1Chapnik Edoi: 10.1016/j.ydbio.2011.11.008
22025453Expression levels of the microRNA maturing microprocessor complex component DGCR8 and the RNA-induced silencing complex (RISC) components argonaute-1, argonaute-2, PACT, TARBP1, and TARBP2 in epithelial skin cancer.Mol Carcinog2012 NovSand Mdoi: 10.1002/mc.20861
21755473Autoregulatory mechanisms controlling the microprocessor.Adv Exp Med Biol2011Triboulet R-
21627030Autoregulatory mechanisms controlling the Microprocessor.Adv Exp Med Biol2010Triboulet R-
21466685Monoallelic deletion of the microRNA biogenesis gene Dgcr8 produces deficits in the development of excitatory synaptic transmission in the prefrontal cortex.Neural Dev2011 Apr 5Schofield CMdoi: 10.1186/1749-8104-6-11.
21273303A microRNA expression signature of osteoclastogenesis.Blood2011 Mar 31Sugatani Tdoi: 10.1182/blood-2010-10-311415
20655853MD simulations of the dsRBP DGCR8 reveal correlated motions that may aid pri-miRNA binding.Biophys J2010 Jul 7Wostenberg Cdoi: 10.1016/j.bpj.2010.04.010.
20558544DGCR8 recognizes primary transcripts of microRNAs through highly cooperative binding and formation of higher-order structures.RNA2010 AugFaller Mdoi: 10.1261/rna.2111310
20506313Structure of the dimerization domain of DiGeorge critical region 8.Protein Sci2010 JulSenturia Rdoi: 10.1002/pro.414.
25176654The RNA-binding protein DDX1 promotes primary microRNA maturation and inhibits ovarian tumor progression.Cell Rep2014 Sep 11Han Cdoi: 10.1016/j.celrep.2014.07.058
24449907Processing of microRNA primary transcripts requires heme in mammalian cells.Proc Natl Acad Sci U S A2014 Feb 4Weitz SHdoi: 10.1073/pnas.1309915111
24239349Phosphorylation of DGCR8 increases its intracellular stability and induces a progrowth miRNA profile.Cell Rep2013 Nov 27Herbert KMdoi: 10.1016/j.celrep.2013.10.017
24166303Primary microRNA processing assay reconstituted using recombinant Drosha and DGCR8.Methods Mol Biol2014Barr Idoi: 10.1007/978-1-62703-703-7_5.
23863141Cellular functions of the microprocessor.Biochem Soc Trans2013 AugMacias Sdoi: 10.1042/BST20130011.
27546061Analysis of Heme Iron Coordination in DGCR8: The Heme-Binding Component of the Microprocessor Complex.Biochemistry2016 Sep 13Girvan HMdoi: 10.1021/acs.biochem.6b00204
26683315A heterotrimer model of the complete Microprocessor complex revealed by single-molecule subunit counting.RNA2016 FebHerbert KMdoi: 10.1261/rna.054684.115
26833131Deficiency in DGCR8-dependent canonical microRNAs causes infertility due to multiple abnormalities during uterine development in mice.Sci Rep2016 Feb 2Kim YSdoi: 10.1038/srep20242.
26804549Upregulation of the double-stranded RNA binding protein DGCR8 in invasive ductal breast carcinoma.Gene2016 May 1Fardmanesh Hdoi: 10.1016/j.gene.2016.01.033
26126715The kinase ABL phosphorylates the microprocessor subunit DGCR8 to stimulate primary microRNA processing in response to DNA damage.Sci Signal2015 Jun 30Tu CCdoi: 10.1126/scisignal.aaa4468.
26091172Cobalt(III) Protoporphyrin Activates the DGCR8 Protein and Can Compensate microRNA Processing Deficiency.Chem Biol2015 Jun 18Barr Idoi: 10.1016/j.chembiol.2015.05.015.
25851436Deformability in the cleavage site of primary microRNA is not sensed by the double-stranded RNA binding domains in the microprocessor component DGCR8.Proteins2015 JunQuarles KAdoi: 10.1002/prot.24810
25823356Silencing the double-stranded RNA binding protein DGCR8 inhibits ovarian cancer cell proliferation, migration, and invasion.Pharm Res2015 MarGuo Y-
25799998N6-methyladenosine marks primary microRNAs for processing.Nature2015 Mar 26Alarcon CRdoi: 10.1038/nature14281
27766492CO and NO bind to Fe(II) DiGeorge critical region 8 heme but do not restore primary microRNA processing activity.J Biol Inorg Chem2016 DecHines JP-
28846091NEAT1 scaffolds RNA-binding proteins and the Microprocessor to globally enhance pri-miRNA processing.Nat Struct Mol Biol2017 OctJiang Ldoi: 10.1038/nsmb.3455
29042235Splicing factors as regulators of miRNA biogenesis - links to human disease.Semin Cell Dev Biol2018 JulRatnadiwakara Mdoi: 10.1016/j.semcdb.2017.10.008
29362439Deletion of DGCR8 in VSMCs of adult mice results in loss of vascular reactivity, reduced blood pressure and neointima formation.Sci Rep2018 Jan 23Zou Ydoi: 10.1038/s41598-018-19660-z.
31039132HPV shapes tumor transcriptome by globally modifying the pool of RNA binding protein-binding motif.Aging (Albany NY)2019 Apr 29Wu Ydoi: 10.18632/aging.101927.
15574589The Drosha-DGCR8 complex in primary microRNA processing.Genes Dev2004 Dec 15Han J-
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000407755DGCR8-2034129-ENSP00000384726740 (aa)-Q8WYQ5
ENST00000351989DGCR8-2014514XM_006724268ENSP00000263209773 (aa)XP_006724331Q8WYQ5
ENST00000495826DGCR8-2094695--- (aa)--
ENST00000485802DGCR8-206555--- (aa)--
ENST00000491892DGCR8-207630--- (aa)--
ENST00000498171DGCR8-2103661--- (aa)--
ENST00000495351DGCR8-208508--- (aa)--
ENST00000475941DGCR8-2052669--- (aa)--
ENST00000383024DGCR8-2024419-ENSP00000372488740 (aa)-Q8WYQ5
ENST00000457069DGCR8-204770-ENSP00000409625125 (aa)-C9JSD5
Gene Model
Click here to download ENSG00000128191's gene model file
GWAS
ensgIDSNPChromosomePositionSNP-risk TraitPubmedID95% CIOr or BEAT EFO ID
ENSG00000128191rs1123675332220104310GSelf-reported math ability30038396[0.0088-0.0186] unit decrease0.0137EFO_0004875
ENSG00000128191rs16402992220110836?Serum metabolite levels23093944[NR] unit increase0.02459EFO_0005653
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000128191's network

* RBP PPI network refers to all genes directly bind to RBP
Orthologs
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000128191DGCR810096.378ENSAMEG00000011732DGCR810096.378Ailuropoda_melanoleuca
ENSG00000128191DGCR89571.974ENSACIG00000020103dgcr810069.811Amphilophus_citrinellus
ENSG00000128191DGCR89572.523ENSAOCG00000009444dgcr810070.328Amphiprion_ocellaris
ENSG00000128191DGCR89572.391ENSAPEG00000004916dgcr810070.202Amphiprion_percula
ENSG00000128191DGCR89572.526ENSATEG00000015435dgcr810070.588Anabas_testudineus
ENSG00000128191DGCR810084.407ENSAPLG00000004281DGCR810084.407Anas_platyrhynchos
ENSG00000128191DGCR810082.732ENSACAG00000008031DGCR810082.732Anolis_carolinensis
ENSG00000128191DGCR810099.224ENSANAG00000013710DGCR810099.224Aotus_nancymaae
ENSG00000128191DGCR89571.859ENSACLG00000019757dgcr810071.505Astatotilapia_calliptera
ENSG00000128191DGCR89573.067ENSAMXG00000017429dgcr89673.325Astyanax_mexicanus
ENSG00000128191DGCR810090.686ENSBTAG00000019869DGCR810091.462Bos_taurus
ENSG00000128191DGCR810099.612ENSCJAG00000010780DGCR810099.612Callithrix_jacchus
ENSG00000128191DGCR810096.378ENSCAFG00000014196DGCR810096.378Canis_familiaris
ENSG00000128191DGCR810096.378ENSCAFG00020007769DGCR810096.378Canis_lupus_dingo
ENSG00000128191DGCR810090.686ENSCHIG00000019845DGCR810090.815Capra_hircus
ENSG00000128191DGCR810097.542ENSTSYG00000027809DGCR810097.542Carlito_syrichta
ENSG00000128191DGCR810091.200ENSCAPG00000007081DGCR8100100.000Cavia_aperea
ENSG00000128191DGCR810095.990ENSCPOG00000002952DGCR810096.424Cavia_porcellus
ENSG00000128191DGCR8100100.000ENSCCAG00000036620DGCR810099.612Cebus_capucinus
ENSG00000128191DGCR8100100.000ENSCATG00000030676DGCR810099.871Cercocebus_atys
ENSG00000128191DGCR810096.248ENSCLAG00000013910DGCR810096.248Chinchilla_lanigera
ENSG00000128191DGCR8100100.000ENSCSAG00000011993DGCR810099.871Chlorocebus_sabaeus
ENSG00000128191DGCR810083.742ENSCPBG00000016973DGCR810083.742Chrysemys_picta_bellii
ENSG00000128191DGCR8100100.000ENSCANG00000029485DGCR810099.871Colobus_angolensis_palliatus
ENSG00000128191DGCR810095.602ENSCGRG00001000935-10095.602Cricetulus_griseus_chok1gshd
ENSG00000128191DGCR810095.602ENSCGRG00000005319-10095.602Cricetulus_griseus_crigri
ENSG00000128191DGCR89571.429ENSCSEG00000011546dgcr810069.472Cynoglossus_semilaevis
ENSG00000128191DGCR89571.410ENSCVAG00000008664dgcr810069.270Cyprinodon_variegatus
ENSG00000128191DGCR89572.680ENSDARG00000035564dgcr810070.625Danio_rerio
ENSG00000128191DGCR810094.567ENSDNOG00000010345DGCR810094.567Dasypus_novemcinctus
ENSG00000128191DGCR810095.860ENSDORG00000028551-10095.860Dipodomys_ordii
ENSG00000128191DGCR87237.415FBgn0039861pasha8540.600Drosophila_melanogaster
ENSG00000128191DGCR810088.000ENSETEG00000015987-6887.917Echinops_telfairi
ENSG00000128191DGCR87645.763ENSEBUG00000011988dgcr88545.991Eptatretus_burgeri
ENSG00000128191DGCR810095.731ENSEASG00005010521DGCR810095.731Equus_asinus_asinus
ENSG00000128191DGCR810095.472ENSECAG00000009295DGCR810095.472Equus_caballus
ENSG00000128191DGCR887100.000ENSEEUG00000011818DGCR891100.000Erinaceus_europaeus
ENSG00000128191DGCR810071.156ENSELUG00000006969dgcr810071.156Esox_lucius
ENSG00000128191DGCR810096.766ENSFCAG00000006801DGCR810097.082Felis_catus
ENSG00000128191DGCR810083.634ENSFALG00000008149DGCR810083.634Ficedula_albicollis
ENSG00000128191DGCR810096.636ENSFDAG00000008236DGCR810096.636Fukomys_damarensis
ENSG00000128191DGCR89572.259ENSFHEG00000007016dgcr810069.949Fundulus_heteroclitus
ENSG00000128191DGCR89572.886ENSGMOG00000007715dgcr810070.844Gadus_morhua
ENSG00000128191DGCR810084.149ENSGALG00000033126DGCR810084.149Gallus_gallus
ENSG00000128191DGCR89570.312ENSGAFG00000006516dgcr810068.820Gambusia_affinis
ENSG00000128191DGCR89573.628ENSGACG00000012975dgcr810071.355Gasterosteus_aculeatus
ENSG00000128191DGCR810084.129ENSGAGG00000024260DGCR810084.129Gopherus_agassizii
ENSG00000128191DGCR8100100.000ENSGGOG00000000780DGCR810099.871Gorilla_gorilla
ENSG00000128191DGCR89571.859ENSHBUG00000008555dgcr810069.712Haplochromis_burtoni
ENSG00000128191DGCR810096.248ENSHGLG00000016999DGCR810096.248Heterocephalus_glaber_female
ENSG00000128191DGCR810096.248ENSHGLG00100014468DGCR810096.248Heterocephalus_glaber_male
ENSG00000128191DGCR810068.447ENSHCOG00000003315dgcr810068.447Hippocampus_comes
ENSG00000128191DGCR89573.077ENSIPUG00000016755DGCR89673.077Ictalurus_punctatus
ENSG00000128191DGCR810096.378ENSSTOG00000023936DGCR810096.378Ictidomys_tridecemlineatus
ENSG00000128191DGCR810095.602ENSJJAG00000014171-10095.602Jaculus_jaculus
ENSG00000128191DGCR89573.031ENSKMAG00000009087dgcr810070.791Kryptolebias_marmoratus
ENSG00000128191DGCR89570.855ENSLBEG00000025152dgcr810069.183Labrus_bergylta
ENSG00000128191DGCR89577.570ENSLACG00000017462DGCR89877.763Latimeria_chalumnae
ENSG00000128191DGCR810075.441ENSLOCG00000002491dgcr810075.441Lepisosteus_oculatus
ENSG00000128191DGCR810096.248ENSLAFG00000013724DGCR810096.248Loxodonta_africana
ENSG00000128191DGCR8100100.000ENSMFAG00000033708DGCR810099.741Macaca_fascicularis
ENSG00000128191DGCR8100100.000ENSMMUG00000020098DGCR810099.741Macaca_mulatta
ENSG00000128191DGCR8100100.000ENSMNEG00000009733DGCR810099.871Macaca_nemestrina
ENSG00000128191DGCR8100100.000ENSMLEG00000030324DGCR810099.871Mandrillus_leucophaeus
ENSG00000128191DGCR89571.566ENSMAMG00000020856dgcr810069.594Mastacembelus_armatus
ENSG00000128191DGCR89571.859ENSMZEG00005018646dgcr810069.712Maylandia_zebra
ENSG00000128191DGCR810077.320ENSMGAG00000001534DGCR810077.320Meleagris_gallopavo
ENSG00000128191DGCR810095.343ENSMAUG00000000517-10095.343Mesocricetus_auratus
ENSG00000128191DGCR810097.930ENSMICG00000030145DGCR810097.930Microcebus_murinus
ENSG00000128191DGCR810095.602ENSMOCG00000014743-10095.602Microtus_ochrogaster
ENSG00000128191DGCR89572.644ENSMMOG00000014823dgcr810070.588Mola_mola
ENSG00000128191DGCR810082.239ENSMODG00000010334DGCR810082.239Monodelphis_domestica
ENSG00000128191DGCR89572.237ENSMALG00000015163dgcr810069.937Monopterus_albus
ENSG00000128191DGCR810095.213MGP_CAROLIEiJ_G0020542-10095.213Mus_caroli
ENSG00000128191DGCR810095.343ENSMUSG00000022718Dgcr810095.343Mus_musculus
ENSG00000128191DGCR810095.213MGP_PahariEiJ_G0016247-10095.213Mus_pahari
ENSG00000128191DGCR810091.591MGP_SPRETEiJ_G0021437-10091.591Mus_spretus
ENSG00000128191DGCR89896.552ENSMPUG00000004005DGCR810096.552Mustela_putorius_furo
ENSG00000128191DGCR810094.049ENSMLUG00000017533DGCR810094.049Myotis_lucifugus
ENSG00000128191DGCR810095.860ENSNGAG00000003283-10095.860Nannospalax_galili
ENSG00000128191DGCR89571.990ENSNBRG00000002412dgcr810069.837Neolamprologus_brichardi
ENSG00000128191DGCR8100100.000ENSNLEG00000005643DGCR810099.741Nomascus_leucogenys
ENSG00000128191DGCR810073.643ENSMEUG00000001041DGCR810073.643Notamacropus_eugenii
ENSG00000128191DGCR810092.755ENSOPRG00000008457DGCR810092.755Ochotona_princeps
ENSG00000128191DGCR810095.731ENSODEG00000016402DGCR810095.731Octodon_degus
ENSG00000128191DGCR89573.727ENSONIG00000011072dgcr810069.462Oreochromis_niloticus
ENSG00000128191DGCR810095.084ENSOCUG00000003612DGCR810095.084Oryctolagus_cuniculus
ENSG00000128191DGCR89570.806ENSORLG00000015160dgcr810068.813Oryzias_latipes
ENSG00000128191DGCR89571.258ENSORLG00020022168dgcr810069.241Oryzias_latipes_hni
ENSG00000128191DGCR89571.164ENSORLG00015012766dgcr810069.153Oryzias_latipes_hsok
ENSG00000128191DGCR89570.696ENSOMEG00000019137dgcr810068.719Oryzias_melastigma
ENSG00000128191DGCR810097.413ENSOGAG00000004851DGCR810097.413Otolemur_garnettii
ENSG00000128191DGCR810088.114ENSOARG00000018063DGCR810088.889Ovis_aries
ENSG00000128191DGCR8100100.000ENSPPAG00000039507DGCR8100100.000Pan_paniscus
ENSG00000128191DGCR810096.636ENSPPRG00000018958DGCR810096.636Panthera_pardus
ENSG00000128191DGCR810096.507ENSPTIG00000010980DGCR810096.507Panthera_tigris_altaica
ENSG00000128191DGCR8100100.000ENSPTRG00000014073DGCR8100100.000Pan_troglodytes
ENSG00000128191DGCR8100100.000ENSPANG00000019987DGCR810099.741Papio_anubis
ENSG00000128191DGCR89574.502ENSPKIG00000010338dgcr810072.370Paramormyrops_kingsleyae
ENSG00000128191DGCR810082.968ENSPSIG00000002300-10082.968Pelodiscus_sinensis
ENSG00000128191DGCR89572.405ENSPMGG00000021200dgcr810070.226Periophthalmus_magnuspinnatus
ENSG00000128191DGCR810095.472ENSPEMG00000018266-10095.472Peromyscus_maniculatus_bairdii
ENSG00000128191DGCR810082.558ENSPCIG00000027728DGCR810082.558Phascolarctos_cinereus
ENSG00000128191DGCR89570.665ENSPFOG00000010796dgcr810068.539Poecilia_formosa
ENSG00000128191DGCR89570.366ENSPLAG00000002812dgcr810068.290Poecilia_latipinna
ENSG00000128191DGCR89570.757ENSPMEG00000024459dgcr810068.664Poecilia_mexicana
ENSG00000128191DGCR89570.312ENSPREG00000018877dgcr810068.618Poecilia_reticulata
ENSG00000128191DGCR8100100.000ENSPPYG00000011591DGCR810099.871Pongo_abelii
ENSG00000128191DGCR810090.400ENSPCAG00000015976DGCR810090.298Procavia_capensis
ENSG00000128191DGCR810098.400ENSPCOG00000025377DGCR810098.318Propithecus_coquereli
ENSG00000128191DGCR810091.200ENSPVAG00000015694DGCR810085.770Pteropus_vampyrus
ENSG00000128191DGCR89571.859ENSPNYG00000004486dgcr810069.712Pundamilia_nyererei
ENSG00000128191DGCR89573.446ENSPNAG00000016504dgcr89674.413Pygocentrus_nattereri
ENSG00000128191DGCR810094.567ENSRNOG00000001886Dgcr810094.567Rattus_norvegicus
ENSG00000128191DGCR8100100.000ENSRBIG00000015201DGCR810099.871Rhinopithecus_bieti
ENSG00000128191DGCR8100100.000ENSRROG00000029948DGCR810099.871Rhinopithecus_roxellana
ENSG00000128191DGCR810099.741ENSSBOG00000022975DGCR810099.741Saimiri_boliviensis_boliviensis
ENSG00000128191DGCR810082.558ENSSHAG00000002274DGCR810082.558Sarcophilus_harrisii
ENSG00000128191DGCR89574.572ENSSFOG00015017499dgcr810072.682Scleropages_formosus
ENSG00000128191DGCR89573.936ENSSMAG00000019677dgcr810071.665Scophthalmus_maximus
ENSG00000128191DGCR89573.553ENSSDUG00000002478dgcr810071.447Seriola_dumerili
ENSG00000128191DGCR89573.553ENSSLDG00000015762dgcr810071.447Seriola_lalandi_dorsalis
ENSG00000128191DGCR810095.343ENSSARG00000009292DGCR810095.343Sorex_araneus
ENSG00000128191DGCR810082.429ENSSPUG00000014967DGCR810082.429Sphenodon_punctatus
ENSG00000128191DGCR89572.895ENSSPAG00000009666dgcr810070.692Stegastes_partitus
ENSG00000128191DGCR810093.661ENSSSCG00000010135DGCR810093.661Sus_scrofa
ENSG00000128191DGCR89571.728ENSTRUG00000013594dgcr810069.587Takifugu_rubripes
ENSG00000128191DGCR89573.138ENSTNIG00000016762dgcr810071.029Tetraodon_nigroviridis
ENSG00000128191DGCR810090.400ENSTBEG00000007196DGCR810078.913Tupaia_belangeri
ENSG00000128191DGCR810090.168ENSTTRG00000008121DGCR810090.168Tursiops_truncatus
ENSG00000128191DGCR810096.378ENSUAMG00000010847DGCR810096.378Ursus_americanus
ENSG00000128191DGCR810096.378ENSUMAG00000007398DGCR810096.378Ursus_maritimus
ENSG00000128191DGCR810096.507ENSVVUG00000025413DGCR810096.507Vulpes_vulpes
ENSG00000128191DGCR89579.512ENSXETG00000006320dgcr810077.477Xenopus_tropicalis
ENSG00000128191DGCR89570.052ENSXCOG00000015141dgcr810067.995Xiphophorus_couchianus
ENSG00000128191DGCR89570.221ENSXMAG00000002426dgcr810068.284Xiphophorus_maculatus
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0003725double-stranded RNA binding21873635.IBAFunction
GO:0003725double-stranded RNA binding17704815.IDAFunction
GO:0004525ribonuclease III activity21873635.IBAFunction
GO:0004525ribonuclease III activity15574589.IDAFunction
GO:0005515protein binding15574589.19626115.22222205.22796965.23602568.23995758.24581491.25416956.26321680.26496610.IPIFunction
GO:0005634nucleus15574589.IDAComponent
GO:0005654nucleoplasm-TASComponent
GO:0005730nucleolus-IEAComponent
GO:0005737cytoplasm-IDAComponent
GO:0010586miRNA metabolic process-TASProcess
GO:0020037heme binding21873635.IBAFunction
GO:0020037heme binding24449907.24910438.IDAFunction
GO:0031053primary miRNA processing21873635.IBAProcess
GO:0031053primary miRNA processing15531877.15574589.24449907.24910438.IDAProcess
GO:0042802identical protein binding15574589.17159994.IPIFunction
GO:0042803protein homodimerization activity15574589.IDAFunction
GO:0046872metal ion binding-IEAFunction
GO:0070877microprocessor complex21873635.IBAComponent
GO:0070877microprocessor complex15574589.IDAComponent
GO:0070878primary miRNA binding21873635.IBAFunction
GO:0070878primary miRNA binding24910438.IDAFunction
GO:0090502RNA phosphodiester bond hydrolysis, endonucleolytic-IEAProcess
To top

Copyright © , Bioinformatics Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, China. All Rights Reserved.

Any comment and suggestion, please contact us