EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
26140362	Role and regulation of coordinately expressed de novo purine biosynthetic enzymes PPAT and PAICS in lung cancer.	Oncotarget	2015 Sep 15	Goswami MT	-

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr4	56459582	3'UTR	rs746939298		0.11
BLCA	chr4	56452022	Missense_Mutation	novel	E308K	0.2
BLCA	chr4	56441687	Missense_Mutation	novel	Y14C	0.5
BLCA	chr4	56448519	Missense_Mutation	novel	M165I	0.25
BLCA	chr4	56436261	Splice_Site	novel		0.43
BRCA	chr4	56453641	Missense_Mutation	novel	R331G	0.18
BRCA	chr4	56448544	Missense_Mutation	NA	E174Q	0.14
BRCA	chr4	56436272	5'UTR	novel		0.5
BRCA	chr4	56441750	Missense_Mutation	rs775711628	S35F	0.39
BRCA	chr4	56448552	Silent	NA	L176L	0.25
BRCA	chr4	56446861	Nonsense_Mutation	novel	*E127_L128insWEEL**	0.04
BRCA	chr4	56448725	Missense_Mutation	NA	D197H	0.26
CESC	chr4	56446785	Missense_Mutation	NA	R102K	0.42
CESC	chr4	56441709	Silent	novel	V21V	0.37
CESC	chr4	56436136	Intron	novel		0.6
COAD	chr4	56436195	Intron	novel		0.57
COAD	chr4	56436205	Intron	novel		0.31
COAD	chr4	56436177	Intron	novel		0.18
COAD	chr4	56451982	Silent	NA	P294P	0.44
COAD	chr4	56451977	Missense_Mutation	NA	I293V	0.36
COAD	chr4	56441713	Missense_Mutation	rs773166026	E23K	0.08
COAD	chr4	56448538	Missense_Mutation	NA	I172V	0.32
COAD	chr4	56436188	Intron	rs373567251		0.88
KIRC	chr4	56452051	Frame_Shift_Ins	novel	*G318Kfs25**	0.08
LGG	chr4	56459427	Missense_Mutation	novel	Q389H	0.16
LIHC	chr4	56446805	Missense_Mutation	NA	L109F	0.43
LIHC	chr4	56459472	Silent	novel	A404A	0.33
LIHC	chr4	56446698	Missense_Mutation	novel	I73S	0.27
LIHC	chr4	56436251	Intron	novel		0.43
LUAD	chr4	56448549	Missense_Mutation	NA	I175M	0.38
LUAD	chr4	56435797	5'UTR	novel		0.24
LUSC	chr4	56459582	3'UTR	rs746939298		0.35
LUSC	chr4	56448563	Nonsense_Mutation	novel	W180*	0.38
PAAD	chr4	56459374	Missense_Mutation	novel	L372I	0.14
PAAD	chr4	56459390	Missense_Mutation	novel	V377A	0.13
READ	chr4	56451948	Missense_Mutation	NA	K283T	0.27
READ	chr4	56451992	Nonsense_Mutation	rs772673782	R298*	0.33
SARC	chr4	56435911	5'UTR	novel		0.38
SKCM	chr4	56446805	Missense_Mutation	NA	L109F	0.25
SKCM	chr4	56459394	Silent	NA	L378L	0.23
SKCM	chr4	56451952	Silent	NA	I284I	0.2
STAD	chr4	56452006	Silent	rs776423311	A302A	0.27
STAD	chr4	56459567	3'UTR	rs773503084		0.14
UCEC	chr4	56459524	Nonsense_Mutation	NA	E422*	0.32
UCEC	chr4	56448801	Missense_Mutation	rs761243513	R222Q	0.44
UCEC	chr4	56448522	Silent	novel	S166S	0.38
UCEC	chr4	56441853	Missense_Mutation	novel	Q69H	0.41
UCEC	chr4	56448800	Nonsense_Mutation	NA	R222*	0.37
UCEC	chr4	56448579	Silent	novel	C185C	0.22
UCEC	chr4	56453653	Silent	novel	L335L	0.47
UCEC	chr4	56453719	Missense_Mutation	NA	W357G	0.33
UCEC	chr4	56448800	Nonsense_Mutation	NA	R222*	0.44
UCEC	chr4	56451992	Nonsense_Mutation	rs772673782	R298*	0.36
UCEC	chr4	56446790	Missense_Mutation	novel	A104T	0.38
UCEC	chr4	56453746	Missense_Mutation	novel	L366I	0.43
UCEC	chr4	56441713	Missense_Mutation	rs773166026	E23K	0.48
UCEC	chr4	56441664	Splice_Region	novel	V6V	0.19
UCEC	chr4	56450625	Missense_Mutation	novel	R232W	0.14
UCEC	chr4	56448434	Missense_Mutation	novel	D137G	0.43
UCEC	chr4	56459554	3'UTR	novel		0.32
UCEC	chr4	56446817	Missense_Mutation	novel	P113S	0.45

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
LUAD	AMP	0.1027	0.060325
MESO	DEL	0.3218	0.075661
SARC	AMP	0.1984	0.13735
TGCT	AMP	0.1267	4.2593e-09

Survival Analysis

Cancer	P-value	Q-value
THYM	0.032	Kaplan-Meier Survival Analysis
SARC	0.00017	Kaplan-Meier Survival Analysis
MESO	0.01	Kaplan-Meier Survival Analysis
HNSC	0.011	Kaplan-Meier Survival Analysis
SKCM	0.00089	Kaplan-Meier Survival Analysis
BRCA	0.0047	Kaplan-Meier Survival Analysis
KIRP	0.0001	Kaplan-Meier Survival Analysis
COAD	0.039	Kaplan-Meier Survival Analysis
PAAD	0.0017	Kaplan-Meier Survival Analysis
CESC	0.033	Kaplan-Meier Survival Analysis
READ	0.011	Kaplan-Meier Survival Analysis
KICH	0.0022	Kaplan-Meier Survival Analysis
UCEC	0.045	Kaplan-Meier Survival Analysis
LIHC	0.00049	Kaplan-Meier Survival Analysis
LGG	0.0001	Kaplan-Meier Survival Analysis
CHOL	0.046	Kaplan-Meier Survival Analysis
THCA	0.016	Kaplan-Meier Survival Analysis
LUAD	0.0003	Kaplan-Meier Survival Analysis
OV	0.0019	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

PPI

Gene Ontology

Description

Ensembl ID: ENSG00000128050 (Gene tree)
Gene ID: 10606
Gene Symbol: PAICS
Alias: ADE2H1|AIRC|PAIS
Full Name: phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 28,839 bases
Position: chr4:56,435,741-56,464,579
Accession: 8587
RBP type: non-canonical RBP
Summary: This gene encodes a bifunctional enzyme containing phosphoribosylaminoimidazole carboxylase activity in its N-terminal region and phosphoribosylaminoimidazole succinocarboxamide synthetase in its C-terminal region. It catalyzes steps 6 and 7 of purine biosynthesis. The gene is closely linked and divergently transcribed with a locus that encodes an enzyme in the same pathway, and transcription of the two genes is coordinately regulated. The human genome contains several pseudogenes of this gene. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
25547032	Identification of putative interactions between swine and human influenza A virus nucleoprotein and human host proteins.	Virol J	2014 Dec 30	Generous A	doi: 10.1186/s12985-014-0228-6.

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000505164	PAICS-204	1514	-	ENSP00000424053	413 (aa)	-	E9PBS1
ENST00000399688	PAICS-202	3297	-	ENSP00000382595	432 (aa)	-	P22234
ENST00000264221	PAICS-201	3339	XM_011534366	ENSP00000264221	425 (aa)	XP_011532668	P22234
ENST00000512576	PAICS-207	6480	-	ENSP00000421096	425 (aa)	-	P22234
ENST00000514888	PAICS-208	3340	-	ENSP00000424907	333 (aa)	-	D6RF62
ENST00000504188	PAICS-203	491	-	-	- (aa)	-	-
ENST00000510584	PAICS-206	557	-	-	- (aa)	-	-
ENST00000508554	PAICS-205	698	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000128050's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa00230	Purine metabolism	KEGG
hsa01100	Metabolic pathways	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000128050	Monocytes	9.9310000E-006	-

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000128050's network

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0004638	phosphoribosylaminoimidazole carboxylase activity	-	IEA	Function
GO:0004639	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity	-	IEA	Function
GO:0005515	protein binding	16189514.19060904.25416956.26871637.	IPI	Function
GO:0005524	ATP binding	-	IEA	Function
GO:0005737	cytoplasm	25468996.	IDA	Component
GO:0005829	cytosol	21873635.	IBA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0006189	'de novo' IMP biosynthetic process	-	IEA	Process
GO:0009113	purine nucleobase biosynthetic process	2253271.	TAS	Process
GO:0009168	purine ribonucleoside monophosphate biosynthetic process	-	TAS	Process
GO:0016020	membrane	19946888.	HDA	Component
GO:0042802	identical protein binding	16169070.16189514.21988832.25416956.	IPI	Function
GO:0043727	5-amino-4-imidazole carboxylate lyase activity	-	IEA	Function
GO:0045296	cadherin binding	25468996.	HDA	Function
GO:0070062	extracellular exosome	20458337.23533145.	HDA	Component

EuRBPDB

Note: to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

PPI

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.