EuRBPDB

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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
26140362Role and regulation of coordinately expressed de novo purine biosynthetic enzymes PPAT and PAICS in lung cancer.Oncotarget2015 Sep 15Goswami MT-

Differential Expression

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
BLCAchr4564595823'UTRrs7469392980.11
BLCAchr456452022Missense_MutationnovelE308K0.2
BLCAchr456441687Missense_MutationnovelY14C0.5
BLCAchr456448519Missense_MutationnovelM165I0.25
BLCAchr456436261Splice_Sitenovel0.43
BRCAchr456453641Missense_MutationnovelR331G0.18
BRCAchr456448544Missense_MutationNAE174Q0.14
BRCAchr4564362725'UTRnovel0.5
BRCAchr456441750Missense_Mutationrs775711628S35F0.39
BRCAchr456448552SilentNAL176L0.25
BRCAchr456446861Nonsense_MutationnovelE127_L128insWEE*L0.04
BRCAchr456448725Missense_MutationNAD197H0.26
CESCchr456446785Missense_MutationNAR102K0.42
CESCchr456441709SilentnovelV21V0.37
CESCchr456436136Intronnovel0.6
COADchr456436195Intronnovel0.57
COADchr456436205Intronnovel0.31
COADchr456436177Intronnovel0.18
COADchr456451982SilentNAP294P0.44
COADchr456451977Missense_MutationNAI293V0.36
COADchr456441713Missense_Mutationrs773166026E23K0.08
COADchr456448538Missense_MutationNAI172V0.32
COADchr456436188Intronrs3735672510.88
KIRCchr456452051Frame_Shift_InsnovelG318Kfs*250.08
LGGchr456459427Missense_MutationnovelQ389H0.16
LIHCchr456446805Missense_MutationNAL109F0.43
LIHCchr456459472SilentnovelA404A0.33
LIHCchr456446698Missense_MutationnovelI73S0.27
LIHCchr456436251Intronnovel0.43
LUADchr456448549Missense_MutationNAI175M0.38
LUADchr4564357975'UTRnovel0.24
LUSCchr4564595823'UTRrs7469392980.35
LUSCchr456448563Nonsense_MutationnovelW180*0.38
PAADchr456459374Missense_MutationnovelL372I0.14
PAADchr456459390Missense_MutationnovelV377A0.13
READchr456451948Missense_MutationNAK283T0.27
READchr456451992Nonsense_Mutationrs772673782R298*0.33
SARCchr4564359115'UTRnovel0.38
SKCMchr456446805Missense_MutationNAL109F0.25
SKCMchr456459394SilentNAL378L0.23
SKCMchr456451952SilentNAI284I0.2
STADchr456452006Silentrs776423311A302A0.27
STADchr4564595673'UTRrs7735030840.14
UCECchr456459524Nonsense_MutationNAE422*0.32
UCECchr456448801Missense_Mutationrs761243513R222Q0.44
UCECchr456448522SilentnovelS166S0.38
UCECchr456441853Missense_MutationnovelQ69H0.41
UCECchr456448800Nonsense_MutationNAR222*0.37
UCECchr456448579SilentnovelC185C0.22
UCECchr456453653SilentnovelL335L0.47
UCECchr456453719Missense_MutationNAW357G0.33
UCECchr456448800Nonsense_MutationNAR222*0.44
UCECchr456451992Nonsense_Mutationrs772673782R298*0.36
UCECchr456446790Missense_MutationnovelA104T0.38
UCECchr456453746Missense_MutationnovelL366I0.43
UCECchr456441713Missense_Mutationrs773166026E23K0.48
UCECchr456441664Splice_RegionnovelV6V0.19
UCECchr456450625Missense_MutationnovelR232W0.14
UCECchr456448434Missense_MutationnovelD137G0.43
UCECchr4564595543'UTRnovel0.32
UCECchr456446817Missense_MutationnovelP113S0.45

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
LUADAMP0.10270.060325
MESODEL0.32180.075661
SARCAMP0.19840.13735
TGCTAMP0.12674.2593e-09

Survival Analysis
CancerP-value Q-value
THYM0.032

Kaplan-Meier Survival Analysis

SARC0.00017

Kaplan-Meier Survival Analysis

MESO0.01

Kaplan-Meier Survival Analysis

HNSC0.011

Kaplan-Meier Survival Analysis

SKCM0.00089

Kaplan-Meier Survival Analysis

BRCA0.0047

Kaplan-Meier Survival Analysis

KIRP0.0001

Kaplan-Meier Survival Analysis

COAD0.039

Kaplan-Meier Survival Analysis

PAAD0.0017

Kaplan-Meier Survival Analysis

CESC0.033

Kaplan-Meier Survival Analysis

READ0.011

Kaplan-Meier Survival Analysis

KICH0.0022

Kaplan-Meier Survival Analysis

UCEC0.045

Kaplan-Meier Survival Analysis

LIHC0.00049

Kaplan-Meier Survival Analysis

LGG0.0001

Kaplan-Meier Survival Analysis

CHOL0.046

Kaplan-Meier Survival Analysis

THCA0.016

Kaplan-Meier Survival Analysis

LUAD0.0003

Kaplan-Meier Survival Analysis

OV0.0019

Kaplan-Meier Survival Analysis

Drugs

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Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBPome
  • Literatures
  • Expression
  • Transcripts
  • Gene Model
  • Pathways
  • Phenotypes
  • PPI
  • Gene Ontology
Description
Ensembl ID
ENSG00000128050 (Gene tree)
Gene ID
10606
Gene Symbol
PAICS
Alias
ADE2H1|AIRC|PAIS
Full Name
phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Plus strand
Length
28,839 bases
Position
chr4:56,435,741-56,464,579
Accession
8587
RBP type
non-canonical RBP
Summary
This gene encodes a bifunctional enzyme containing phosphoribosylaminoimidazole carboxylase activity in its N-terminal region and phosphoribosylaminoimidazole succinocarboxamide synthetase in its C-terminal region. It catalyzes steps 6 and 7 of purine biosynthesis. The gene is closely linked and divergently transcribed with a locus that encodes an enzyme in the same pathway, and transcription of the two genes is coordinately regulated. The human genome contains several pseudogenes of this gene. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & HEK2932019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & HEK2932018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
29431736Capturing the interactome of newly transcribed RNAPolyT-RICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
29431736Capturing the interactome of newly transcribed RNARICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & MCF10A2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & MCF72018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & U2OS2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
25547032Identification of putative interactions between swine and human influenza A virus nucleoprotein and human host proteins.Virol J2014 Dec 30Generous Adoi: 10.1186/s12985-014-0228-6.
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000505164PAICS-2041514-ENSP00000424053413 (aa)-E9PBS1
ENST00000399688PAICS-2023297-ENSP00000382595432 (aa)-P22234
ENST00000264221PAICS-2013339XM_011534366ENSP00000264221425 (aa)XP_011532668P22234
ENST00000512576PAICS-2076480-ENSP00000421096425 (aa)-P22234
ENST00000514888PAICS-2083340-ENSP00000424907333 (aa)-D6RF62
ENST00000504188PAICS-203491--- (aa)--
ENST00000510584PAICS-206557--- (aa)--
ENST00000508554PAICS-205698--- (aa)--
Gene Model
Click here to download ENSG00000128050's gene model file
Pathways
Pathway IDPathway NameSource
hsa00230Purine metabolismKEGG
hsa01100Metabolic pathwaysKEGG
Phenotypes
ensgIDTraitpValuePubmed ID
ENSG00000128050Monocytes9.9310000E-006-
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000128050's network

* RBP PPI network refers to all genes directly bind to RBP
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0004638phosphoribosylaminoimidazole carboxylase activity-IEAFunction
GO:0004639phosphoribosylaminoimidazolesuccinocarboxamide synthase activity-IEAFunction
GO:0005515protein binding16189514.19060904.25416956.26871637.IPIFunction
GO:0005524ATP binding-IEAFunction
GO:0005737cytoplasm25468996.IDAComponent
GO:0005829cytosol21873635.IBAComponent
GO:0005829cytosol-TASComponent
GO:0006189'de novo' IMP biosynthetic process-IEAProcess
GO:0009113purine nucleobase biosynthetic process2253271.TASProcess
GO:0009168purine ribonucleoside monophosphate biosynthetic process-TASProcess
GO:0016020membrane19946888.HDAComponent
GO:0042802identical protein binding16169070.16189514.21988832.25416956.IPIFunction
GO:00437275-amino-4-imidazole carboxylate lyase activity-IEAFunction
GO:0045296cadherin binding25468996.HDAFunction
GO:0070062extracellular exosome20458337.23533145.HDAComponent
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