EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
17628721	Cloning, genomic organization, and tissue-specific expression of the RASL11B gene.	Biochim Biophys Acta	2007 Jul-Aug	Stolle K	-

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
BLCA	chr4	52865365	Missense_Mutation	novel	Q103E	0.42	MMR_HSR1
BLCA	chr4	52864552	Nonsense_Mutation	novel	Q92*	0.38	MMR_HSR1
BLCA	chr4	52862502	5'UTR	novel		0.11
BLCA	chr4	52864480	Missense_Mutation	novel	N68H	0.45	MMR_HSR1
BLCA	chr4	52862541	Missense_Mutation	NA	E12K	0.21
BLCA	chr4	52864541	Missense_Mutation	novel	T88I	0.05	MMR_HSR1
BRCA	chr4	52865539	Missense_Mutation	NA	Q161E	0.44
BRCA	chr4	52865433	Silent	NA	S125S	0.26
BRCA	chr4	52863303	Missense_Mutation	novel	G60S	0.07	MMR_HSR1
COAD	chr4	52863320	Silent	novel	N65N	0.2
COAD	chr4	52865372	Missense_Mutation	NA	N105T	0.16	MMR_HSR1
COAD	chr4	52865702	Missense_Mutation	novel	R215K	0.21
COAD	chr4	52863294	Nonsense_Mutation	rs777475073	R57*	0.42	MMR_HSR1
HNSC	chr4	52865774	Missense_Mutation	novel	S239Y	0.27
LGG	chr4	52865603	Missense_Mutation	novel	S182Y	0.04
LUAD	chr4	52865436	Silent	rs771325908	Y126Y	0.13
LUAD	chr4	52864534	Missense_Mutation	NA	Q86E	0.15	MMR_HSR1
LUAD	chr4	52862464	5'UTR	novel		0.48
LUAD	chr4	52865592	Missense_Mutation	NA	F178L	0.2
LUAD	chr4	52862482	5'UTR	novel		0.43
LUSC	chr4	52862600	Silent	novel	R31R	0.54
LUSC	chr4	52862601	Missense_Mutation	novel	R32G	0.53
LUSC	chr4	52862549	Silent	NA	P14P	0.15
OV	chr4	52862516	Silent	novel	L3L	0.49
OV	chr4	52865395	Missense_Mutation	novel	A113S	0.04	MMR_HSR1
OV	chr4	52865596	Missense_Mutation	novel	E180Q	0.05
OV	chr4	52865930	3'UTR	novel		0.57
PAAD	chr4	52865627	Missense_Mutation	novel	V190A	0.17
PAAD	chr4	52865767	Missense_Mutation	novel	A237S	0.16
SKCM	chr4	52865824	3'UTR	novel		0.41
STAD	chr4	52862456	5'UTR	novel		0.3
STAD	chr4	52862636	Silent	NA	G43G	0.38
STAD	chr4	52862485	5'UTR	novel		0.17
STAD	chr4	52862567	Silent	novel	A20A	0.25
STAD	chr4	52862628	Missense_Mutation	NA	A41T	0.28	MMR_HSR1
STAD	chr4	52865441	Missense_Mutation	NA	L128H	0.22	MMR_HSR1
STAD	chr4	52862493	5'UTR	rs527975465		0.2
UCEC	chr4	52863315	Silent	novel	R64R	0.26
UCEC	chr4	52865937	3'UTR	novel		0.22
UCEC	chr4	52866822	3'UTR	novel		0.4
UCEC	chr4	52865384	Missense_Mutation	rs760740865	R109H	0.39	MMR_HSR1
UCEC	chr4	52865699	Missense_Mutation	rs759146855	R214Q	0.37
UCEC	chr4	52864491	Silent	novel	T71T	0.26
UCEC	chr4	52866822	3'UTR	novel		0.4
UCEC	chr4	52865343	Silent	novel	E95E	0.59
UCEC	chr4	52865489	Missense_Mutation	rs370329858	R144Q	0.24	MMR_HSR1
UCEC	chr4	52866499	3'UTR	novel		0.75
UCEC	chr4	52864522	Missense_Mutation	rs765474300	A82T	0.2	MMR_HSR1
UCEC	chr4	52865367	Missense_Mutation	novel	Q103H	0.15	MMR_HSR1
UCEC	chr4	52865343	Silent	novel	E95E	0.38
UCEC	chr4	52866778	3'UTR	novel		0.29

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
SARC	AMP	0.2451	0.13735

Survival Analysis

Cancer	P-value	Q-value
HNSC	0.031	Kaplan-Meier Survival Analysis
KIRP	0.00028	Kaplan-Meier Survival Analysis
LGG	0.0077	Kaplan-Meier Survival Analysis
THCA	0.0016	Kaplan-Meier Survival Analysis
UVM	0.00039	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBDs

Expression

Transcripts

Gene Model

Phenotype

PPI

Ortholog

Gene Ontology

Description

Ensembl ID: ENSG00000128045 (Gene tree)
Gene ID: 65997
Gene Symbol: RASL11B
Alias: -
Full Name: RAS like family 11 member B
Gene Type: protein_coding
Specie: Homo_sapiens
Strand: Plus strand
Length: 4,546 bases
Position: chr4:52,862,290-52,866,835
Accession: 23804
Summary: RASL11B is a member of the small GTPase protein family with a high degree of similarity to RAS (see HRAS, MIM 190020) proteins.[supplied by OMIM, Nov 2008]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000248706	MMR_HSR1	PF01926.23	3.3e-07	1	1

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000248706	RASL11B-201	1995	-	ENSP00000248706	248 (aa)	-	Q9BPW5
ENST00000505041	RASL11B-202	1733	-	-	- (aa)	-	-
ENST00000515677	RASL11B-203	661	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000128045's gene model file

Phenotype

ensgID	Trait	pValue	Pubmed ID
ENSG00000128045	Platelet Function Tests	1.4958800E-005	-

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000128045's network

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy	Species
ENSG00000128045	RASL11B	100	92.742	ENSAMEG00000008116	RASL11B	100	92.742	Ailuropoda_melanoleuca
ENSG00000128045	RASL11B	100	58.527	ENSACIG00000023481	rasl11b	100	59.690	Amphilophus_citrinellus
ENSG00000128045	RASL11B	100	59.144	ENSAOCG00000005269	rasl11b	100	59.144	Amphiprion_ocellaris
ENSG00000128045	RASL11B	100	59.144	ENSAPEG00000015415	rasl11b	100	59.144	Amphiprion_percula
ENSG00000128045	RASL11B	90	79.279	ENSACAG00000005848	RASL11B	91	79.279	Anolis_carolinensis
ENSG00000128045	RASL11B	85	99.057	ENSANAG00000030414	RASL11B	100	99.057	Aotus_nancymaae
ENSG00000128045	RASL11B	100	60.311	ENSACLG00000016163	rasl11b	100	61.479	Astatotilapia_calliptera
ENSG00000128045	RASL11B	100	65.116	ENSAMXG00000042814	rasl11b	100	65.116	Astyanax_mexicanus
ENSG00000128045	RASL11B	100	95.968	ENSBTAG00000020647	RASL11B	100	95.968	Bos_taurus
ENSG00000128045	RASL11B	100	97.984	ENSCJAG00000018548	RASL11B	100	97.984	Callithrix_jacchus
ENSG00000128045	RASL11B	81	90.196	ENSCAFG00000002019	RASL11B	98	93.627	Canis_familiaris
ENSG00000128045	RASL11B	100	92.063	ENSCAFG00020001800	RASL11B	100	94.841	Canis_lupus_dingo
ENSG00000128045	RASL11B	100	94.758	ENSCHIG00000024365	RASL11B	100	94.758	Capra_hircus
ENSG00000128045	RASL11B	100	81.452	ENSTSYG00000028064	RASL11B	100	81.452	Carlito_syrichta
ENSG00000128045	RASL11B	100	97.581	ENSCCAG00000037560	RASL11B	100	97.581	Cebus_capucinus
ENSG00000128045	RASL11B	100	98.387	ENSCATG00000035296	RASL11B	100	98.387	Cercocebus_atys
ENSG00000128045	RASL11B	100	98.387	ENSCSAG00000004968	RASL11B	100	98.387	Chlorocebus_sabaeus
ENSG00000128045	RASL11B	100	83.534	ENSCPBG00000025014	RASL11B	100	83.534	Chrysemys_picta_bellii
ENSG00000128045	RASL11B	100	98.790	ENSCANG00000031790	RASL11B	100	98.790	Colobus_angolensis_palliatus
ENSG00000128045	RASL11B	100	95.161	ENSCGRG00001011283	Rasl11b	100	95.161	Cricetulus_griseus_chok1gshd
ENSG00000128045	RASL11B	100	95.161	ENSCGRG00000014793	-	100	95.161	Cricetulus_griseus_crigri
ENSG00000128045	RASL11B	100	57.198	ENSCSEG00000020208	rasl11b	100	57.198	Cynoglossus_semilaevis
ENSG00000128045	RASL11B	100	64.314	ENSDARG00000015611	rasl11b	100	64.314	Danio_rerio
ENSG00000128045	RASL11B	88	96.347	ENSDORG00000030008	Rasl11b	100	96.347	Dipodomys_ordii
ENSG00000128045	RASL11B	100	91.129	ENSETEG00000005614	RASL11B	100	93.145	Echinops_telfairi
ENSG00000128045	RASL11B	100	95.161	ENSEASG00005019943	RASL11B	100	95.161	Equus_asinus_asinus
ENSG00000128045	RASL11B	100	95.565	ENSECAG00000003789	RASL11B	100	95.565	Equus_caballus
ENSG00000128045	RASL11B	100	95.565	ENSEEUG00000000023	RASL11B	100	95.565	Erinaceus_europaeus
ENSG00000128045	RASL11B	100	95.565	ENSFCAG00000045595	RASL11B	100	95.565	Felis_catus
ENSG00000128045	RASL11B	88	94.064	ENSFDAG00000003278	RASL11B	99	94.064	Fukomys_damarensis
ENSG00000128045	RASL11B	100	58.366	ENSFHEG00000019106	rasl11b	100	59.144	Fundulus_heteroclitus
ENSG00000128045	RASL11B	100	79.032	ENSGALG00000013948	RASL11B	100	79.032	Gallus_gallus
ENSG00000128045	RASL11B	100	58.984	ENSGAFG00000019285	rasl11b	100	60.156	Gambusia_affinis
ENSG00000128045	RASL11B	100	83.133	ENSGAGG00000007636	RASL11B	100	83.133	Gopherus_agassizii
ENSG00000128045	RASL11B	100	100.000	ENSGGOG00000012197	RASL11B	100	100.000	Gorilla_gorilla
ENSG00000128045	RASL11B	100	93.952	ENSHGLG00000018686	-	100	93.952	Heterocephalus_glaber_female
ENSG00000128045	RASL11B	100	93.952	ENSHGLG00100012272	RASL11B	100	93.952	Heterocephalus_glaber_male
ENSG00000128045	RASL11B	100	61.961	ENSIPUG00000009956	rasl11b	100	61.961	Ictalurus_punctatus
ENSG00000128045	RASL11B	100	95.968	ENSSTOG00000027610	RASL11B	100	95.968	Ictidomys_tridecemlineatus
ENSG00000128045	RASL11B	100	91.935	ENSJJAG00000022168	Rasl11b	100	93.145	Jaculus_jaculus
ENSG00000128045	RASL11B	100	56.705	ENSLBEG00000020868	rasl11b	100	57.471	Labrus_bergylta
ENSG00000128045	RASL11B	100	67.742	ENSLOCG00000014119	rasl11b	99	67.742	Lepisosteus_oculatus
ENSG00000128045	RASL11B	99	95.951	ENSLAFG00000008178	RASL11B	99	95.951	Loxodonta_africana
ENSG00000128045	RASL11B	100	98.387	ENSMFAG00000037233	RASL11B	100	98.387	Macaca_fascicularis
ENSG00000128045	RASL11B	100	98.387	ENSMMUG00000037547	RASL11B	100	98.387	Macaca_mulatta
ENSG00000128045	RASL11B	100	98.387	ENSMNEG00000034500	RASL11B	100	98.387	Macaca_nemestrina
ENSG00000128045	RASL11B	83	99.034	ENSMLEG00000029372	RASL11B	100	99.034	Mandrillus_leucophaeus
ENSG00000128045	RASL11B	100	60.484	ENSMAMG00000014747	rasl11b	100	60.484	Mastacembelus_armatus
ENSG00000128045	RASL11B	100	59.922	ENSMZEG00005020278	rasl11b	100	61.089	Maylandia_zebra
ENSG00000128045	RASL11B	100	77.823	ENSMGAG00000011909	RASL11B	100	77.823	Meleagris_gallopavo
ENSG00000128045	RASL11B	100	93.952	ENSMAUG00000003048	Rasl11b	100	93.952	Mesocricetus_auratus
ENSG00000128045	RASL11B	100	93.548	ENSMICG00000042188	RASL11B	100	93.548	Microcebus_murinus
ENSG00000128045	RASL11B	100	93.952	ENSMOCG00000022471	Rasl11b	100	93.952	Microtus_ochrogaster
ENSG00000128045	RASL11B	100	56.048	ENSMMOG00000006390	rasl11b	94	56.048	Mola_mola
ENSG00000128045	RASL11B	100	87.402	ENSMODG00000020648	RASL11B	100	88.189	Monodelphis_domestica
ENSG00000128045	RASL11B	100	57.588	ENSMALG00000013062	rasl11b	100	57.977	Monopterus_albus
ENSG00000128045	RASL11B	100	93.952	MGP_CAROLIEiJ_G0027302	Rasl11b	100	93.952	Mus_caroli
ENSG00000128045	RASL11B	100	94.355	ENSMUSG00000049907	Rasl11b	100	94.355	Mus_musculus
ENSG00000128045	RASL11B	100	93.952	MGP_PahariEiJ_G0017083	Rasl11b	100	93.952	Mus_pahari
ENSG00000128045	RASL11B	100	94.758	MGP_SPRETEiJ_G0028297	Rasl11b	100	94.758	Mus_spretus
ENSG00000128045	RASL11B	100	93.976	ENSMPUG00000005791	RASL11B	100	93.976	Mustela_putorius_furo
ENSG00000128045	RASL11B	100	94.758	ENSNGAG00000009169	Rasl11b	100	94.758	Nannospalax_galili
ENSG00000128045	RASL11B	100	60.311	ENSNBRG00000003915	rasl11b	100	61.479	Neolamprologus_brichardi
ENSG00000128045	RASL11B	100	98.790	ENSNLEG00000008176	RASL11B	100	98.790	Nomascus_leucogenys
ENSG00000128045	RASL11B	100	87.402	ENSMEUG00000013835	RASL11B	100	88.189	Notamacropus_eugenii
ENSG00000128045	RASL11B	100	92.742	ENSODEG00000010294	RASL11B	100	92.742	Octodon_degus
ENSG00000128045	RASL11B	100	59.533	ENSONIG00000003031	rasl11b	100	61.089	Oreochromis_niloticus
ENSG00000128045	RASL11B	100	91.935	ENSOCUG00000000719	RASL11B	100	91.935	Oryctolagus_cuniculus
ENSG00000128045	RASL11B	100	91.600	ENSOGAG00000009539	RASL11B	100	93.600	Otolemur_garnettii
ENSG00000128045	RASL11B	100	94.758	ENSOARG00000018640	RASL11B	100	94.758	Ovis_aries
ENSG00000128045	RASL11B	100	100.000	ENSPPAG00000031269	RASL11B	100	100.000	Pan_paniscus
ENSG00000128045	RASL11B	100	95.565	ENSPPRG00000023266	RASL11B	100	95.565	Panthera_pardus
ENSG00000128045	RASL11B	91	96.000	ENSPTIG00000018380	RASL11B	91	96.000	Panthera_tigris_altaica
ENSG00000128045	RASL11B	100	99.597	ENSPTRG00000016058	RASL11B	100	99.597	Pan_troglodytes
ENSG00000128045	RASL11B	100	98.387	ENSPANG00000024162	RASL11B	100	98.387	Papio_anubis
ENSG00000128045	RASL11B	100	60.241	ENSPKIG00000003511	rasl11b	100	60.241	Paramormyrops_kingsleyae
ENSG00000128045	RASL11B	100	59.144	ENSPMGG00000005269	rasl11b	100	59.144	Periophthalmus_magnuspinnatus
ENSG00000128045	RASL11B	100	87.402	ENSPCIG00000014777	RASL11B	100	88.189	Phascolarctos_cinereus
ENSG00000128045	RASL11B	100	60.236	ENSPLAG00000002398	rasl11b	100	60.236	Poecilia_latipinna
ENSG00000128045	RASL11B	100	60.236	ENSPMEG00000000230	rasl11b	100	60.236	Poecilia_mexicana
ENSG00000128045	RASL11B	100	58.755	ENSPREG00000019386	rasl11b	100	60.311	Poecilia_reticulata
ENSG00000128045	RASL11B	100	99.597	ENSPPYG00000014775	RASL11B	100	99.597	Pongo_abelii
ENSG00000128045	RASL11B	100	95.582	ENSPCAG00000008349	RASL11B	100	95.582	Procavia_capensis
ENSG00000128045	RASL11B	100	92.742	ENSPCOG00000019628	RASL11B	100	93.145	Propithecus_coquereli
ENSG00000128045	RASL11B	68	96.552	ENSPVAG00000000713	RASL11B	67	96.552	Pteropus_vampyrus
ENSG00000128045	RASL11B	100	60.700	ENSPNYG00000011286	rasl11b	100	61.479	Pundamilia_nyererei
ENSG00000128045	RASL11B	100	63.813	ENSPNAG00000001348	rasl11b	100	63.813	Pygocentrus_nattereri
ENSG00000128045	RASL11B	100	94.355	ENSRNOG00000002097	Rasl11b	100	94.355	Rattus_norvegicus
ENSG00000128045	RASL11B	100	98.387	ENSRBIG00000032651	RASL11B	100	98.387	Rhinopithecus_bieti
ENSG00000128045	RASL11B	100	98.387	ENSRROG00000029923	RASL11B	100	98.387	Rhinopithecus_roxellana
ENSG00000128045	RASL11B	100	97.177	ENSSBOG00000019612	RASL11B	100	97.177	Saimiri_boliviensis_boliviensis
ENSG00000128045	RASL11B	100	55.939	ENSSMAG00000014061	rasl11b	100	56.705	Scophthalmus_maximus
ENSG00000128045	RASL11B	100	58.915	ENSSDUG00000022959	rasl11b	100	58.915	Seriola_dumerili
ENSG00000128045	RASL11B	100	91.129	ENSSARG00000000017	RASL11B	100	91.129	Sorex_araneus
ENSG00000128045	RASL11B	100	81.526	ENSSPUG00000017298	RASL11B	100	81.526	Sphenodon_punctatus
ENSG00000128045	RASL11B	100	58.755	ENSSPAG00000014922	rasl11b	100	59.144	Stegastes_partitus
ENSG00000128045	RASL11B	100	94.758	ENSSSCG00000008835	RASL11B	100	94.758	Sus_scrofa
ENSG00000128045	RASL11B	100	59.846	ENSTRUG00000021970	rasl11b	100	59.846	Takifugu_rubripes
ENSG00000128045	RASL11B	98	92.593	ENSTBEG00000007199	RASL11B	100	92.593	Tupaia_belangeri
ENSG00000128045	RASL11B	100	92.771	ENSUAMG00000020617	RASL11B	100	92.771	Ursus_americanus
ENSG00000128045	RASL11B	100	73.790	ENSXETG00000011677	rasl11b	100	73.790	Xenopus_tropicalis
ENSG00000128045	RASL11B	100	59.289	ENSXMAG00000014332	rasl11b	100	60.236	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003924	GTPase activity	-	IEA	Function
GO:0005160	transforming growth factor beta receptor binding	-	IEA	Function
GO:0005525	GTP binding	-	IEA	Function
GO:0007165	signal transduction	-	IEA	Process
GO:0016020	membrane	-	IEA	Component
GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway	-	IEA	Process

EuRBPDB

Note: to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBDs

Expression

Transcripts

Gene Model

Phenotype

PPI

Ortholog

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.