EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
29624814	eIF2β, a subunit of translation-initiation factor EIF2, is a potential therapeutic target for non-small cell lung cancer.	Cancer Sci	2018 Jun	Tanaka I	doi: 10.1111/cas.13602

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
BLCA	chr20	34096713	Silent	rs766502344	V209V	0.19
BLCA	chr20	34089875	Missense_Mutation	rs767028331	S286L	0.13	eIF-5_eIF-2B
BRCA	chr20	34097479	Missense_Mutation	NA	I157M	0.26
BRCA	chr20	34089645	3'UTR	novel		0.19
BRCA	chr20	34089783	Missense_Mutation	NA	G317C	0.15
BRCA	chr20	34090561	Missense_Mutation	NA	R261K	0.17	eIF-5_eIF-2B
CESC	chr20	34098510	Missense_Mutation	NA	E141Q	0.38
CESC	chr20	34089759	Nonsense_Mutation	NA	R325*	0.28
CESC	chr20	34093688	Missense_Mutation	novel	E243K	0.25	eIF-5_eIF-2B
COAD	chr20	34105443	Nonsense_Mutation	NA	E40*	0.42
COAD	chr20	34103522	Missense_Mutation	NA	K79N	0.07
COAD	chr20	34112102	Silent	NA	G3G	0.07
COAD	chr20	34096770	Missense_Mutation	NA	K190N	0.13
DLBC	chr20	34103534	Silent	novel	F75F	0.34
DLBC	chr20	34089878	Missense_Mutation	NA	R285Q	0.41	eIF-5_eIF-2B
ESCA	chr20	34089343	3'UTR	novel		0.37
GBM	chr20	34098602	Missense_Mutation	novel	P110Q	0.07
GBM	chr20	34089743	Missense_Mutation	novel	A330V	0.21
HNSC	chr20	34097470	Silent	novel	S160S	0.17
HNSC	chr20	34089758	Missense_Mutation	NA	R325Q	0.39
HNSC	chr20	34097505	Nonsense_Mutation	novel	E149*	0.14
HNSC	chr20	34089759	Nonsense_Mutation	NA	R325*	0.23
HNSC	chr20	34098533	Missense_Mutation	novel	F133S	0.19
KIRC	chr20	34112110	Translation_Start_Site	NA	M1?	0.33
KIRC	chr20	34112111	5'UTR	novel		0.33
LAML	chr20	34089797	Missense_Mutation	novel	A312G	0.13
LIHC	chr20	34096597	Splice_Site	novel	X224_splice	0.04
LUAD	chr20	34089762	Missense_Mutation	novel	K324E	0.16
LUAD	chr20	34089783	Missense_Mutation	NA	G317S	0.16
LUSC	chr20	34089778	Missense_Mutation	NA	F318L	0.13
LUSC	chr20	34089759	Nonsense_Mutation	NA	R325*	0.37
LUSC	chr20	34089791	Frame_Shift_Del	novel	*I314Qfs19**	0.12
OV	chr20	34089702	3'UTR	novel		0.24
OV	chr20	34089846	Missense_Mutation	NA	R296G	0.08	eIF-5_eIF-2B
OV	chr20	34105489	Missense_Mutation	NA	M24I	0.14
READ	chr20	34096695	Missense_Mutation	NA	K215N	0.05	eIF-5_eIF-2B
SARC	chr20	34098616	Silent	novel	S105S	0.22
SKCM	chr20	34105370	Missense_Mutation	novel	K64R	0.32
STAD	chr20	34096712	Missense_Mutation	rs760616209	V210I	0.34	eIF-5_eIF-2B
STAD	chr20	34089878	Missense_Mutation	NA	R285Q	0.29	eIF-5_eIF-2B
STAD	chr20	34105419	Missense_Mutation	novel	P48S	0.23
STAD	chr20	34089871	Silent	NA	P287P	0.22
THCA	chr20	34089758	Missense_Mutation	NA	R325P	0.35
UCEC	chr20	34096770	Missense_Mutation	NA	K190N	0.3
UCEC	chr20	34105374	Missense_Mutation	novel	K63E	0.05
UCEC	chr20	34088633	3'UTR	novel		0.53
UCEC	chr20	34089241	3'UTR	novel		0.53
UCEC	chr20	34093724	Missense_Mutation	NA	R231C	0.41	eIF-5_eIF-2B
UCEC	chr20	34105546	Splice_Site	NA	X6_splice	0.15
UCEC	chr20	34096703	Missense_Mutation	NA	G213R	0.5	eIF-5_eIF-2B
UCEC	chr20	34105498	Missense_Mutation	novel	K21N	0.06
UCEC	chr20	34089056	3'UTR	novel		0.1
UCEC	chr20	34096770	Missense_Mutation	NA	K190N	0.06
UCEC	chr20	34098538	Silent	novel	V131V	0.49
UCEC	chr20	34089679	3'UTR	novel		0.37
UCEC	chr20	34096794	Silent	rs758044179	R182R	0.22
UCEC	chr20	34098566	Missense_Mutation	novel	G122D	0.37
UCEC	chr20	34088395	3'UTR	novel		0.45
UCEC	chr20	34096713	Silent	rs766502344	V209V	0.57
UCEC	chr20	34089693	3'UTR	rs751116125		0.38
UCEC	chr20	34112167	5'UTR	novel		0.5
UCEC	chr20	34089032	3'UTR	novel		0.33
UCEC	chr20	34088383	3'UTR	novel		0.29
UCEC	chr20	34097479	Silent	novel	I157I	0.16
UCEC	chr20	34105501	Silent	rs769053843	K20K	0.15
UCEC	chr20	34112257	5'UTR	novel		0.51
UCEC	chr20	34089550	3'UTR	novel		0.75
UCEC	chr20	34103539	Missense_Mutation	novel	N74H	0.35
UCEC	chr20	34088319	3'UTR	novel		0.38
UCEC	chr20	34089455	3'UTR	novel		0.42
UCEC	chr20	34089846	Missense_Mutation	NA	R296G	0.44	eIF-5_eIF-2B
UCEC	chr20	34096695	Missense_Mutation	NA	K215N	0.24	eIF-5_eIF-2B
UCEC	chr20	34096727	Missense_Mutation	novel	K205Q	0.17	eIF-5_eIF-2B
UCEC	chr20	34088383	3'UTR	novel		0.35
UCEC	chr20	34089638	3'UTR	novel		0.35
UCEC	chr20	34105546	Splice_Site	NA	X6_splice	0.4
UCEC	chr20	34096770	Missense_Mutation	NA	K190N	0.23
UCEC	chr20	34096796	Nonsense_Mutation	NA	R182*	0.38
UCEC	chr20	34088353	3'UTR	novel		0.44
UCEC	chr20	34112249	5'UTR	novel		0.49
UCEC	chr20	34088612	3'UTR	novel		0.43
UCEC	chr20	34089491	3'UTR	novel		0.35
UCS	chr20	34089862	Silent	novel	I290I	0.05

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
HNSC	AMP	0.3295	5.7791e-06
LAML	DEL	0.0105	0.14746
READ	AMP	0.8667	1.9519e-21

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.0074	Kaplan-Meier Survival Analysis
SARC	0.00023	Kaplan-Meier Survival Analysis
MESO	0.0097	Kaplan-Meier Survival Analysis
ACC	0.0041	Kaplan-Meier Survival Analysis
HNSC	0.0066	Kaplan-Meier Survival Analysis
SKCM	0.048	Kaplan-Meier Survival Analysis
BRCA	0.028	Kaplan-Meier Survival Analysis
ESCA	0.047	Kaplan-Meier Survival Analysis
KIRP	0.0001	Kaplan-Meier Survival Analysis
PAAD	0.0025	Kaplan-Meier Survival Analysis
READ	0.03	Kaplan-Meier Survival Analysis
KICH	0.02	Kaplan-Meier Survival Analysis
UCEC	0.00049	Kaplan-Meier Survival Analysis
LIHC	0.00011	Kaplan-Meier Survival Analysis
LGG	0.032	Kaplan-Meier Survival Analysis
LUAD	0.0086	Kaplan-Meier Survival Analysis
UVM	0.029	Kaplan-Meier Survival Analysis
OV	0.01	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathway

GWAS

PPI

Ortholog

Gene Ontology

Description

Ensembl ID: ENSG00000125977 (Gene tree)
Gene ID: 8894
Gene Symbol: EIF2S2
Alias: EIF2beta|PPP1R67|EIF2
Full Name: eukaryotic translation initiation factor 2 subunit beta
Gene Type: protein_coding
Specie: Homo_sapiens
Strand: Minus strand
Length: 24,035 bases
Position: chr20:34,088,298-34,112,332
Accession: 3266
Summary: Eukaryotic translation initiation factor 2 (EIF-2) functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA and binding to a 40S ribosomal subunit. EIF-2 is composed of three subunits, alpha, beta, and gamma, with the protein encoded by this gene representing the beta subunit. The beta subunit catalyzes the exchange of GDP for GTP, which recycles the EIF-2 complex for another round of initiation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000364119	eIF-5_eIF-2B	PF01873.17	8.8e-41	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	PolyT & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	polyT & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
27453046	Comprehensive Identification of RNA-Binding Domains in Human Cells	PolyT & Hela	2016 Aug 18	Castello A	DOI: 10.1016/j.molcel.2016.06.029

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
10769173	Conserved sequences in the beta subunit of archaeal and eukaryal translation initiation factor 2 (eIF2), absent from eIF5, mediate interaction with eIF2gamma.	Biochem J	2000 May 1	Thompson GM	-

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000374980	EIF2S2-201	2656	XM_017028118	ENSP00000364119	333 (aa)	XP_016883607	P20042

Gene Model

Click here to download ENSG00000125977's gene model file

Pathway

Pathway ID	Pathway Name	Source
hsa03013	RNA transport	KEGG

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000125977	rs6142096	20	34098852	A	Body mass index	30108127	[NR] unit increase	0.014	EFO_0004340

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000125977's network

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy	Species
ENSG00000125977	EIF2S2	100	80.952	ENSAPOG00000016596	eif2s2	100	81.250	Acanthochromis_polyacanthus
ENSG00000125977	EIF2S2	99	97.281	ENSAMEG00000009071	EIF2S2	99	97.281	Ailuropoda_melanoleuca
ENSG00000125977	EIF2S2	99	73.054	ENSACIG00000023655	eif2s2	96	73.653	Amphilophus_citrinellus
ENSG00000125977	EIF2S2	100	80.299	ENSAOCG00000019466	eif2s2	100	81.493	Amphiprion_ocellaris
ENSG00000125977	EIF2S2	100	80.299	ENSAPEG00000013128	eif2s2	100	81.493	Amphiprion_percula
ENSG00000125977	EIF2S2	100	79.104	ENSATEG00000010706	eif2s2	100	80.299	Anabas_testudineus
ENSG00000125977	EIF2S2	99	94.545	ENSAPLG00000013245	EIF2S2	99	94.545	Anas_platyrhynchos
ENSG00000125977	EIF2S2	100	93.114	ENSACAG00000009041	EIF2S2	100	92.216	Anolis_carolinensis
ENSG00000125977	EIF2S2	100	99.099	ENSANAG00000022839	EIF2S2	100	99.099	Aotus_nancymaae
ENSG00000125977	EIF2S2	100	80.000	ENSACLG00000021293	eif2s2	100	80.597	Astatotilapia_calliptera
ENSG00000125977	EIF2S2	100	78.274	ENSAMXG00000040852	eif2s2	100	77.976	Astyanax_mexicanus
ENSG00000125977	EIF2S2	100	75.224	ENSAMXG00000034753	-	100	74.925	Astyanax_mexicanus
ENSG00000125977	EIF2S2	100	96.997	ENSBTAG00000005969	EIF2S2	100	96.997	Bos_taurus
ENSG00000125977	EIF2S2	100	99.099	ENSCJAG00000018334	EIF2S2	100	99.099	Callithrix_jacchus
ENSG00000125977	EIF2S2	100	96.997	ENSCAFG00000007498	EIF2S2	100	96.997	Canis_familiaris
ENSG00000125977	EIF2S2	100	96.997	ENSCAFG00020005078	EIF2S2	96	96.997	Canis_lupus_dingo
ENSG00000125977	EIF2S2	100	96.697	ENSCHIG00000011707	-	100	96.697	Capra_hircus
ENSG00000125977	EIF2S2	100	96.096	ENSCHIG00000026317	-	98	96.096	Capra_hircus
ENSG00000125977	EIF2S2	100	98.498	ENSTSYG00000006525	EIF2S2	100	98.498	Carlito_syrichta
ENSG00000125977	EIF2S2	100	97.898	ENSCPOG00000040226	EIF2S2	100	97.898	Cavia_porcellus
ENSG00000125977	EIF2S2	100	99.099	ENSCCAG00000035446	-	100	99.099	Cebus_capucinus
ENSG00000125977	EIF2S2	100	87.126	ENSCCAG00000025886	-	100	87.425	Cebus_capucinus
ENSG00000125977	EIF2S2	98	79.268	ENSCATG00000031390	-	100	79.268	Cercocebus_atys
ENSG00000125977	EIF2S2	100	99.399	ENSCATG00000044082	-	100	99.399	Cercocebus_atys
ENSG00000125977	EIF2S2	91	77.152	ENSCLAG00000003063	-	100	77.483	Chinchilla_lanigera
ENSG00000125977	EIF2S2	100	97.297	ENSCLAG00000017263	-	100	97.297	Chinchilla_lanigera
ENSG00000125977	EIF2S2	100	69.069	ENSCLAG00000004266	-	100	69.069	Chinchilla_lanigera
ENSG00000125977	EIF2S2	100	96.997	ENSCHOG00000006521	EIF2S2	100	96.997	Choloepus_hoffmanni
ENSG00000125977	EIF2S2	100	95.808	ENSCPBG00000019159	EIF2S2	100	95.808	Chrysemys_picta_bellii
ENSG00000125977	EIF2S2	59	66.667	ENSCSAVG00000011706	-	90	47.866	Ciona_savignyi
ENSG00000125977	EIF2S2	100	99.700	ENSCANG00000034909	-	100	99.700	Colobus_angolensis_palliatus
ENSG00000125977	EIF2S2	100	73.273	ENSCANG00000039168	-	100	73.273	Colobus_angolensis_palliatus
ENSG00000125977	EIF2S2	100	97.898	ENSCGRG00001001614	-	100	97.898	Cricetulus_griseus_chok1gshd
ENSG00000125977	EIF2S2	99	72.590	ENSCGRG00001019733	-	99	72.590	Cricetulus_griseus_chok1gshd
ENSG00000125977	EIF2S2	96	69.018	ENSCGRG00001018890	-	96	69.018	Cricetulus_griseus_chok1gshd
ENSG00000125977	EIF2S2	100	97.898	ENSCGRG00000017568	-	100	97.898	Cricetulus_griseus_crigri
ENSG00000125977	EIF2S2	93	78.778	ENSCGRG00000000744	-	99	78.778	Cricetulus_griseus_crigri
ENSG00000125977	EIF2S2	99	78.012	ENSCGRG00000008333	-	99	78.012	Cricetulus_griseus_crigri
ENSG00000125977	EIF2S2	96	69.018	ENSCGRG00000000784	-	96	69.018	Cricetulus_griseus_crigri
ENSG00000125977	EIF2S2	100	79.941	ENSCSEG00000019767	eif2s2	100	81.711	Cynoglossus_semilaevis
ENSG00000125977	EIF2S2	100	77.910	ENSCVAG00000001869	eif2s2	100	79.822	Cyprinodon_variegatus
ENSG00000125977	EIF2S2	100	78.078	ENSDARG00000053047	eif2s2	100	77.477	Danio_rerio
ENSG00000125977	EIF2S2	98	97.866	ENSDNOG00000047014	-	100	97.866	Dasypus_novemcinctus
ENSG00000125977	EIF2S2	100	74.474	ENSDNOG00000038247	-	100	74.474	Dasypus_novemcinctus
ENSG00000125977	EIF2S2	100	97.598	ENSDORG00000001920	Eif2s2	100	97.598	Dipodomys_ordii
ENSG00000125977	EIF2S2	50	81.818	FBgn0004926	eIF2beta	97	54.896	Drosophila_melanogaster
ENSG00000125977	EIF2S2	100	86.787	ENSETEG00000007060	-	100	87.988	Echinops_telfairi
ENSG00000125977	EIF2S2	100	93.093	ENSETEG00000001922	-	100	93.093	Echinops_telfairi
ENSG00000125977	EIF2S2	75	76.190	ENSETEG00000014821	-	100	75.397	Echinops_telfairi
ENSG00000125977	EIF2S2	56	87.701	ENSEBUG00000014146	eif2s2	100	64.286	Eptatretus_burgeri
ENSG00000125977	EIF2S2	100	97.297	ENSEASG00005008498	EIF2S2	100	97.297	Equus_asinus_asinus
ENSG00000125977	EIF2S2	100	97.297	ENSECAG00000030296	-	100	97.297	Equus_caballus
ENSG00000125977	EIF2S2	100	98.498	ENSECAG00000039017	EIF2S2	100	98.498	Equus_caballus
ENSG00000125977	EIF2S2	100	98.498	ENSECAG00000034606	EIF2S2	100	98.498	Equus_caballus
ENSG00000125977	EIF2S2	100	98.498	ENSECAG00000040547	EIF2S2	100	98.498	Equus_caballus
ENSG00000125977	EIF2S2	79	100.000	ENSEEUG00000005408	EIF2S2	79	100.000	Erinaceus_europaeus
ENSG00000125977	EIF2S2	100	78.869	ENSELUG00000011070	eif2s2	86	78.869	Esox_lucius
ENSG00000125977	EIF2S2	100	97.598	ENSFCAG00000026834	EIF2S2	100	97.598	Felis_catus
ENSG00000125977	EIF2S2	99	93.694	ENSFALG00000010608	EIF2S2	100	92.857	Ficedula_albicollis
ENSG00000125977	EIF2S2	100	97.297	ENSFDAG00000007455	EIF2S2	100	97.297	Fukomys_damarensis
ENSG00000125977	EIF2S2	100	79.403	ENSFHEG00000023125	eif2s2	100	80.597	Fundulus_heteroclitus
ENSG00000125977	EIF2S2	82	65.818	ENSGMOG00000006116	EIF2S2	100	65.818	Gadus_morhua
ENSG00000125977	EIF2S2	100	94.311	ENSGALG00000033196	EIF2S2	100	94.311	Gallus_gallus
ENSG00000125977	EIF2S2	98	78.248	ENSGAFG00000019089	eif2s2	86	79.456	Gambusia_affinis
ENSG00000125977	EIF2S2	82	76.364	ENSGACG00000006117	EIF2S2	100	77.818	Gasterosteus_aculeatus
ENSG00000125977	EIF2S2	100	94.311	ENSGAGG00000016270	EIF2S2	100	94.311	Gopherus_agassizii
ENSG00000125977	EIF2S2	100	89.790	ENSGGOG00000024168	-	100	89.489	Gorilla_gorilla
ENSG00000125977	EIF2S2	100	98.498	ENSGGOG00000026007	-	100	98.498	Gorilla_gorilla
ENSG00000125977	EIF2S2	100	75.375	ENSGGOG00000040789	-	100	75.676	Gorilla_gorilla
ENSG00000125977	EIF2S2	98	100.000	ENSGGOG00000015546	-	100	100.000	Gorilla_gorilla
ENSG00000125977	EIF2S2	100	80.299	ENSHBUG00000011308	eif2s2	100	80.896	Haplochromis_burtoni
ENSG00000125977	EIF2S2	64	87.383	ENSHGLG00000015944	-	100	87.383	Heterocephalus_glaber_female
ENSG00000125977	EIF2S2	100	97.297	ENSHGLG00000015490	EIF2S2	100	97.297	Heterocephalus_glaber_female
ENSG00000125977	EIF2S2	98	85.061	ENSHGLG00000010650	-	92	85.366	Heterocephalus_glaber_female
ENSG00000125977	EIF2S2	100	79.279	ENSHGLG00000018132	-	100	79.279	Heterocephalus_glaber_female
ENSG00000125977	EIF2S2	100	85.285	ENSHGLG00000008578	-	100	85.285	Heterocephalus_glaber_female
ENSG00000125977	EIF2S2	64	87.383	ENSHGLG00100009758	-	100	87.383	Heterocephalus_glaber_male
ENSG00000125977	EIF2S2	64	83.645	ENSHGLG00100014683	-	100	83.645	Heterocephalus_glaber_male
ENSG00000125977	EIF2S2	100	85.285	ENSHGLG00100016407	-	100	85.285	Heterocephalus_glaber_male
ENSG00000125977	EIF2S2	98	85.061	ENSHGLG00100006888	-	92	85.366	Heterocephalus_glaber_male
ENSG00000125977	EIF2S2	100	97.297	ENSHGLG00100005508	EIF2S2	100	97.297	Heterocephalus_glaber_male
ENSG00000125977	EIF2S2	100	82.335	ENSHCOG00000002747	eif2s2	100	83.533	Hippocampus_comes
ENSG00000125977	EIF2S2	100	79.880	ENSIPUG00000012763	eif2s2	100	79.880	Ictalurus_punctatus
ENSG00000125977	EIF2S2	100	98.198	ENSSTOG00000008821	EIF2S2	100	98.198	Ictidomys_tridecemlineatus
ENSG00000125977	EIF2S2	100	97.297	ENSJJAG00000014081	Eif2s2	100	97.297	Jaculus_jaculus
ENSG00000125977	EIF2S2	100	79.167	ENSKMAG00000011963	eif2s2	100	79.762	Kryptolebias_marmoratus
ENSG00000125977	EIF2S2	100	80.000	ENSLBEG00000007307	eif2s2	100	80.597	Labrus_bergylta
ENSG00000125977	EIF2S2	100	83.284	ENSLACG00000010054	EIF2S2	100	83.881	Latimeria_chalumnae
ENSG00000125977	EIF2S2	100	80.473	ENSLOCG00000007205	eif2s2	100	81.065	Lepisosteus_oculatus
ENSG00000125977	EIF2S2	100	96.396	ENSLAFG00000016639	EIF2S2	100	96.396	Loxodonta_africana
ENSG00000125977	EIF2S2	100	99.700	ENSMFAG00000037155	EIF2S2	100	99.700	Macaca_fascicularis
ENSG00000125977	EIF2S2	98	70.245	ENSMFAG00000000300	-	99	70.245	Macaca_fascicularis
ENSG00000125977	EIF2S2	100	69.670	ENSMFAG00000036151	-	100	69.369	Macaca_fascicularis
ENSG00000125977	EIF2S2	98	81.098	ENSMFAG00000035778	-	100	81.098	Macaca_fascicularis
ENSG00000125977	EIF2S2	100	99.700	ENSMMUG00000018095	EIF2S2	100	99.700	Macaca_mulatta
ENSG00000125977	EIF2S2	100	69.670	ENSMMUG00000047825	-	100	69.369	Macaca_mulatta
ENSG00000125977	EIF2S2	100	99.700	ENSMNEG00000029852	EIF2S2	100	99.700	Macaca_nemestrina
ENSG00000125977	EIF2S2	98	99.695	ENSMLEG00000039854	EIF2S2	100	99.695	Mandrillus_leucophaeus
ENSG00000125977	EIF2S2	100	80.597	ENSMAMG00000017178	eif2s2	100	81.791	Mastacembelus_armatus
ENSG00000125977	EIF2S2	100	80.000	ENSMZEG00005020654	eif2s2	100	80.597	Maylandia_zebra
ENSG00000125977	EIF2S2	100	93.413	ENSMGAG00000002174	EIF2S2	100	93.413	Meleagris_gallopavo
ENSG00000125977	EIF2S2	100	98.198	ENSMAUG00000009771	Eif2s2	100	98.198	Mesocricetus_auratus
ENSG00000125977	EIF2S2	100	80.781	ENSMAUG00000008252	-	100	80.480	Mesocricetus_auratus
ENSG00000125977	EIF2S2	97	83.642	ENSMICG00000028840	-	100	83.642	Microcebus_murinus
ENSG00000125977	EIF2S2	100	97.898	ENSMICG00000006944	EIF2S2	100	97.898	Microcebus_murinus
ENSG00000125977	EIF2S2	100	97.898	ENSMOCG00000012809	Eif2s2	100	97.898	Microtus_ochrogaster
ENSG00000125977	EIF2S2	64	90.654	ENSMMOG00000015243	eif2s2	93	93.467	Mola_mola
ENSG00000125977	EIF2S2	100	97.898	ENSMODG00000002805	EIF2S2	100	97.898	Monodelphis_domestica
ENSG00000125977	EIF2S2	100	81.493	ENSMALG00000003653	eif2s2	100	82.090	Monopterus_albus
ENSG00000125977	EIF2S2	100	96.396	MGP_CAROLIEiJ_G0024521	Eif2s2	100	96.396	Mus_caroli
ENSG00000125977	EIF2S2	100	95.495	ENSMUSG00000074656	Eif2s2	100	95.495	Mus_musculus
ENSG00000125977	EIF2S2	100	96.396	MGP_PahariEiJ_G0025965	Eif2s2	100	96.396	Mus_pahari
ENSG00000125977	EIF2S2	100	95.495	MGP_SPRETEiJ_G0025443	Eif2s2	100	95.495	Mus_spretus
ENSG00000125977	EIF2S2	100	98.198	ENSMPUG00000017819	EIF2S2	100	98.198	Mustela_putorius_furo
ENSG00000125977	EIF2S2	100	97.297	ENSMLUG00000005335	EIF2S2	100	97.297	Myotis_lucifugus
ENSG00000125977	EIF2S2	100	98.198	ENSNGAG00000004708	Eif2s2	100	98.198	Nannospalax_galili
ENSG00000125977	EIF2S2	100	80.000	ENSNBRG00000001888	eif2s2	100	80.597	Neolamprologus_brichardi
ENSG00000125977	EIF2S2	100	70.270	ENSNLEG00000036008	-	100	69.970	Nomascus_leucogenys
ENSG00000125977	EIF2S2	87	92.784	ENSNLEG00000011139	-	100	92.784	Nomascus_leucogenys
ENSG00000125977	EIF2S2	100	89.790	ENSNLEG00000010034	EIF2S2	100	89.790	Nomascus_leucogenys
ENSG00000125977	EIF2S2	100	81.081	ENSMEUG00000016056	EIF2S2	100	81.081	Notamacropus_eugenii
ENSG00000125977	EIF2S2	100	98.198	ENSOPRG00000008437	EIF2S2	100	98.198	Ochotona_princeps
ENSG00000125977	EIF2S2	100	92.216	ENSODEG00000012151	-	100	92.216	Octodon_degus
ENSG00000125977	EIF2S2	100	92.239	ENSODEG00000017001	-	100	92.239	Octodon_degus
ENSG00000125977	EIF2S2	100	79.403	ENSONIG00000001927	eif2s2	100	80.000	Oreochromis_niloticus
ENSG00000125977	EIF2S2	100	91.617	ENSOANG00000012907	EIF2S2	100	91.317	Ornithorhynchus_anatinus
ENSG00000125977	EIF2S2	100	97.898	ENSOCUG00000000481	EIF2S2	100	97.898	Oryctolagus_cuniculus
ENSG00000125977	EIF2S2	100	75.148	ENSORLG00000003548	eif2s2	100	78.338	Oryzias_latipes
ENSG00000125977	EIF2S2	98	74.775	ENSORLG00020017474	eif2s2	99	77.711	Oryzias_latipes_hni
ENSG00000125977	EIF2S2	100	75.148	ENSORLG00015009368	eif2s2	100	78.042	Oryzias_latipes_hsok
ENSG00000125977	EIF2S2	100	76.558	ENSOMEG00000005972	eif2s2	100	77.581	Oryzias_melastigma
ENSG00000125977	EIF2S2	90	95.017	ENSOGAG00000032096	-	100	94.684	Otolemur_garnettii
ENSG00000125977	EIF2S2	100	91.291	ENSOGAG00000001417	-	100	91.291	Otolemur_garnettii
ENSG00000125977	EIF2S2	100	95.796	ENSOARG00000009171	EIF2S2	100	95.796	Ovis_aries
ENSG00000125977	EIF2S2	100	94.895	ENSPPAG00000043449	EIF2S2	100	100.000	Pan_paniscus
ENSG00000125977	EIF2S2	100	81.682	ENSPPAG00000033361	-	100	81.381	Pan_paniscus
ENSG00000125977	EIF2S2	100	97.598	ENSPPRG00000015102	EIF2S2	100	97.598	Panthera_pardus
ENSG00000125977	EIF2S2	98	97.561	ENSPTIG00000022041	EIF2S2	100	97.561	Panthera_tigris_altaica
ENSG00000125977	EIF2S2	100	78.679	ENSPTRG00000042999	-	100	78.378	Pan_troglodytes
ENSG00000125977	EIF2S2	100	100.000	ENSPTRG00000013412	EIF2S2	100	100.000	Pan_troglodytes
ENSG00000125977	EIF2S2	100	99.700	ENSPANG00000000615	EIF2S2	100	99.700	Papio_anubis
ENSG00000125977	EIF2S2	100	77.910	ENSPKIG00000007195	-	100	77.612	Paramormyrops_kingsleyae
ENSG00000125977	EIF2S2	100	75.749	ENSPKIG00000004837	eif2s2	100	74.850	Paramormyrops_kingsleyae
ENSG00000125977	EIF2S2	98	94.833	ENSPSIG00000017812	EIF2S2	100	94.833	Pelodiscus_sinensis
ENSG00000125977	EIF2S2	99	82.388	ENSPMGG00000014961	eif2s2	99	82.388	Periophthalmus_magnuspinnatus
ENSG00000125977	EIF2S2	98	85.152	ENSPEMG00000023172	Eif2s2	98	84.195	Peromyscus_maniculatus_bairdii
ENSG00000125977	EIF2S2	100	65.130	ENSPMAG00000006179	eif2s2	100	65.130	Petromyzon_marinus
ENSG00000125977	EIF2S2	100	96.697	ENSPCIG00000011155	EIF2S2	100	96.697	Phascolarctos_cinereus
ENSG00000125977	EIF2S2	100	79.762	ENSPFOG00000006517	eif2s2	100	80.952	Poecilia_formosa
ENSG00000125977	EIF2S2	100	79.762	ENSPLAG00000009078	eif2s2	100	80.952	Poecilia_latipinna
ENSG00000125977	EIF2S2	100	79.762	ENSPMEG00000006021	eif2s2	100	80.952	Poecilia_mexicana
ENSG00000125977	EIF2S2	100	79.167	ENSPREG00000001071	eif2s2	100	80.357	Poecilia_reticulata
ENSG00000125977	EIF2S2	100	89.489	ENSPPYG00000002485	-	100	89.489	Pongo_abelii
ENSG00000125977	EIF2S2	100	100.000	ENSPPYG00000010933	EIF2S2	100	100.000	Pongo_abelii
ENSG00000125977	EIF2S2	100	97.598	ENSPCAG00000016890	EIF2S2	100	97.598	Procavia_capensis
ENSG00000125977	EIF2S2	100	97.297	ENSPCOG00000023384	EIF2S2	100	97.297	Propithecus_coquereli
ENSG00000125977	EIF2S2	100	98.198	ENSPVAG00000015828	EIF2S2	100	98.198	Pteropus_vampyrus
ENSG00000125977	EIF2S2	100	80.000	ENSPNYG00000011241	eif2s2	100	80.597	Pundamilia_nyererei
ENSG00000125977	EIF2S2	100	70.833	ENSPNAG00000011834	eif2s2	100	70.833	Pygocentrus_nattereri
ENSG00000125977	EIF2S2	100	76.418	ENSPNAG00000021187	EIF2S2	100	76.418	Pygocentrus_nattereri
ENSG00000125977	EIF2S2	100	96.697	ENSRNOG00000017447	Eif2s2	100	96.697	Rattus_norvegicus
ENSG00000125977	EIF2S2	100	88.024	ENSRBIG00000042624	-	100	88.024	Rhinopithecus_bieti
ENSG00000125977	EIF2S2	100	91.892	ENSRBIG00000024939	-	100	91.892	Rhinopithecus_bieti
ENSG00000125977	EIF2S2	100	74.702	ENSRBIG00000044133	-	100	74.405	Rhinopithecus_bieti
ENSG00000125977	EIF2S2	97	70.988	ENSRBIG00000041510	-	99	70.370	Rhinopithecus_bieti
ENSG00000125977	EIF2S2	100	90.691	ENSRROG00000029916	-	100	90.691	Rhinopithecus_roxellana
ENSG00000125977	EIF2S2	100	79.880	ENSRROG00000042642	-	100	79.880	Rhinopithecus_roxellana
ENSG00000125977	EIF2S2	98	69.207	ENSRROG00000036519	-	100	69.207	Rhinopithecus_roxellana
ENSG00000125977	EIF2S2	100	74.702	ENSRROG00000032159	-	100	74.405	Rhinopithecus_roxellana
ENSG00000125977	EIF2S2	100	99.399	ENSRROG00000041315	-	100	99.399	Rhinopithecus_roxellana
ENSG00000125977	EIF2S2	68	46.581	YPL237W	-	81	46.218	Saccharomyces_cerevisiae
ENSG00000125977	EIF2S2	100	98.498	ENSSBOG00000020845	EIF2S2	100	98.498	Saimiri_boliviensis_boliviensis
ENSG00000125977	EIF2S2	99	96.970	ENSSHAG00000016875	EIF2S2	99	96.970	Sarcophilus_harrisii
ENSG00000125977	EIF2S2	100	81.138	ENSSFOG00015012298	eif2s2	100	81.138	Scleropages_formosus
ENSG00000125977	EIF2S2	100	77.313	ENSSFOG00015017437	-	100	77.313	Scleropages_formosus
ENSG00000125977	EIF2S2	100	79.403	ENSSMAG00000014875	eif2s2	100	80.597	Scophthalmus_maximus
ENSG00000125977	EIF2S2	100	76.418	ENSSDUG00000016126	eif2s2	100	76.418	Seriola_dumerili
ENSG00000125977	EIF2S2	100	80.000	ENSSLDG00000022805	eif2s2	100	81.194	Seriola_lalandi_dorsalis
ENSG00000125977	EIF2S2	98	88.379	ENSSARG00000002785	EIF2S2	100	88.379	Sorex_araneus
ENSG00000125977	EIF2S2	100	93.114	ENSSPUG00000006216	EIF2S2	100	93.114	Sphenodon_punctatus
ENSG00000125977	EIF2S2	100	80.896	ENSSPAG00000002535	eif2s2	100	82.090	Stegastes_partitus
ENSG00000125977	EIF2S2	100	98.498	ENSSSCG00000026617	EIF2S2	100	98.498	Sus_scrofa
ENSG00000125977	EIF2S2	98	93.939	ENSTGUG00000003689	EIF2S2	100	93.939	Taeniopygia_guttata
ENSG00000125977	EIF2S2	100	80.597	ENSTRUG00000002676	eif2s2	100	81.194	Takifugu_rubripes
ENSG00000125977	EIF2S2	100	80.357	ENSTNIG00000012013	eif2s2	100	80.952	Tetraodon_nigroviridis
ENSG00000125977	EIF2S2	99	87.538	ENSTBEG00000009970	EIF2S2	99	87.538	Tupaia_belangeri
ENSG00000125977	EIF2S2	98	89.939	ENSTTRG00000006594	EIF2S2	100	89.939	Tursiops_truncatus
ENSG00000125977	EIF2S2	100	98.198	ENSUAMG00000006994	EIF2S2	100	98.198	Ursus_americanus
ENSG00000125977	EIF2S2	98	98.171	ENSUMAG00000024105	EIF2S2	100	98.171	Ursus_maritimus
ENSG00000125977	EIF2S2	100	86.186	ENSVPAG00000000375	EIF2S2	100	86.186	Vicugna_pacos
ENSG00000125977	EIF2S2	100	96.697	ENSVVUG00000004519	-	96	96.697	Vulpes_vulpes
ENSG00000125977	EIF2S2	100	83.183	ENSVVUG00000026012	-	100	83.183	Vulpes_vulpes
ENSG00000125977	EIF2S2	77	96.512	ENSVVUG00000021772	-	96	96.512	Vulpes_vulpes
ENSG00000125977	EIF2S2	100	86.905	ENSXETG00000019507	eif2s2	100	85.714	Xenopus_tropicalis
ENSG00000125977	EIF2S2	100	79.464	ENSXCOG00000003237	eif2s2	100	80.655	Xiphophorus_couchianus
ENSG00000125977	EIF2S2	100	79.464	ENSXMAG00000019172	eif2s2	100	80.655	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0001701	in utero embryonic development	-	IEA	Process
GO:0002176	male germ cell proliferation	-	IEA	Process
GO:0003723	RNA binding	22658674.22681889.	HDA	Function
GO:0003743	translation initiation factor activity	16289705.	IDA	Function
GO:0005515	protein binding	11959995.16288713.16932749.25147208.	IPI	Function
GO:0005634	nucleus	12426392.	IDA	Component
GO:0005737	cytoplasm	12426392.	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0005850	eukaryotic translation initiation factor 2 complex	23063529.	IDA	Component
GO:0006413	translational initiation	-	TAS	Process
GO:0008135	translation factor activity, RNA binding	3044606.10805737.	TAS	Function
GO:0008584	male gonad development	-	IEA	Process
GO:0046872	metal ion binding	-	IEA	Function
GO:0055085	transmembrane transport	-	TAS	Process

EuRBPDB

Note: to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathway

GWAS

PPI

Ortholog

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.