EuRBPDB

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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
21702043Phosphorylation of vasodilator-stimulated phosphoprotein Ser239 suppresses filopodia and invadopodia in colon cancer.Int J Cancer2012 Jun 1Zuzga DSdoi: 10.1002/ijc.26257
19081821Lysophosphatidic acid (LPA)-induced vasodilator-stimulated phosphoprotein mediates lamellipodia formation to initiate motility in PC-3 prostate cancer cells.Mol Oncol2008 JunHasegawa Ydoi: 10.1016/j.molonc.2008.03.009.
25051011TNF-α mediated increase of HIF-1α inhibits VASP expression, which reduces alveolar-capillary barrier function during acute lung injury (ALI).PLoS One2014 Jul 22Tang Mdoi: 10.1371/journal.pone.0102967
20802179Focal adhesion assembly in myofibroblasts fosters a microenvironment that promotes tumor growth.Am J Pathol2010 OctKang Ndoi: 10.2353/ajpath.2010.100187
23685951Matrine inhibits the adhesion and migration of BCG823 gastric cancer cells by affecting the structure and function of the vasodilator-stimulated phosphoprotein (VASP).Acta Pharmacol Sin2013 AugZhang JWdoi: 10.1038/aps.2013.15
25543053Serine phosphorylation of vasodilator-stimulated phosphoprotein (VASP) regulates colon cancer cell survival and apoptosis.Life Sci2015 Feb 15Ali Mdoi: 10.1016/j.lfs.2014.12.018
26336132The phosphorylation status of VASP at serine 322 can be predictive for aggressiveness of invasive ductal carcinoma.Oncotarget2015 Oct 6Dppler Hdoi: 10.18632/oncotarget.4965.
22320863HIF-1α acts downstream of TNF-α to inhibit vasodilator-stimulated phosphoprotein expression and modulates the adhesion and proliferation of breast cancer cells.DNA Cell Biol2012 JunSu Kdoi: 10.1089/dna.2011.1563
18813837Positive regulation of migration and invasion by vasodilator-stimulated phosphoprotein via Rac1 pathway in human breast cancer cells.Oncol Rep2008 OctHan G-
19115233Loss of profilin-1 expression enhances breast cancer cell motility by Ena/VASP proteins.J Cell Physiol2009 MayBae YHdoi: 10.1002/jcp.21677.
29460479Label-Free Quantitative Phosphoproteomics Reveals Regulation of Vasodilator-Stimulated Phosphoprotein upon Stathmin-1 Silencing in a Pair of Isogenic Colorectal Cancer Cell Lines.Proteomics2018 AprTan HTdoi: 10.1002/pmic.201700242

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
ACCchr1945521345Missense_MutationnovelA123T0.55
BLCAchr1945523668SilentnovelE282E0.26
BLCAchr1945517957Missense_MutationnovelG69D0.22
BRCAchr1945524601Missense_Mutationrs374049612E330K0.05
BRCAchr1945521319Splice_Regionnovel0.25
BRCAchr19455261983'UTRnovel0.2
BRCAchr1945517750SilentnovelQ31Q0.09
BRCAchr1945523860Missense_MutationnovelR298T0.13
CESCchr1945524654SilentNAV347V0.6
CESCchr1945524618SilentnovelT335T0.13
CESCchr1945517761Missense_Mutationrs571015875R35H0.18
CESCchr1945522757Missense_MutationNAE254K0.17
CHOLchr1945524601Nonsense_MutationnovelE330*0.06
COADchr19455262203'UTRnovel0.38
COADchr19455262033'UTRnovel0.37
COADchr1945523878Splice_SitenovelX304_splice0.18
COADchr1945522219Splice_SitenovelX160_splice0.42
COADchr1945522772Missense_MutationNAG259R0.1
COADchr1945521330Frame_Shift_DelnovelP119Lfs*340.18
COADchr1945525990Missense_MutationnovelE364D0.08
COADchr1945522354Frame_Shift_DelNAA167Lfs*1010.36
ESCAchr1945522542SilentnovelA227A0.5
GBMchr1945524616Missense_MutationNAT335A0.06
GBMchr1945517823Missense_MutationnovelP56T0.58
GBMchr1945524116Missense_MutationnovelW310C0.13
HNSCchr1945517799Missense_MutationNAR48C0.09
HNSCchr1945524141Missense_MutationnovelR319W0.5
KIRCchr1945521350SilentNAL124L0.38
KIRPchr19455262583'UTRnovel0.48
LIHCchr1945518085Missense_MutationNAA112S0.38
LUADchr1945517982SilentnovelP77P0.17
LUADchr1945525989Missense_MutationnovelE364G0.12
LUSCchr1945523873Missense_MutationnovelQ302H0.14
LUSCchr1945517998Missense_MutationnovelR83G0.21
LUSCchr1945517766Missense_MutationNAQ37K0.31
LUSCchr1945517752Missense_MutationNAA32V0.44
LUSCchr1945517753Silentrs777159219A32A0.41
LUSCchr1945525988Missense_MutationnovelE364Q0.15
OVchr1945523666Nonsense_MutationnovelE282*0.07
OVchr1945525971Frame_Shift_InsnovelE358Dfs*210.1
OVchr1945517787Missense_Mutationrs777492777A44T0.21
SARCchr19455265613'UTRnovel0.07
SARCchr1945524106Missense_Mutationrs371283026R307Q0.38
SKCMchr1945518022Missense_MutationNAL91F0.25
SKCMchr19455262063'UTRnovel0.65
STADchr1945517722Missense_Mutationrs749426631R22Q0.21
STADchr1945524106Missense_Mutationrs371283026R307Q0.29
STADchr1945524108SilentNAR308R0.29
STADchr19455261993'UTRnovel0.3
THYMchr19455268543'UTRnovel0.48
UCECchr1945517761Missense_Mutationrs571015875R35H0.3
UCECchr1945523656SilentnovelT278T0.48
UCECchr1945522760Missense_MutationnovelS255G0.2
UCECchr19455261973'UTRnovel0.29
UCECchr1945522204SilentnovelR155R0.32
UCECchr19455265633'UTRnovel0.44
UCECchr19455263203'UTRnovel0.54
UCECchr1945517741Silentrs373932046T28T0.55
UCECchr1945522543Missense_Mutationrs760633493A228T0.53
UCECchr19455261853'UTRnovel0.56
UCECchr1945517978Frame_Shift_DelnovelN78Tfs*330.47
UCECchr19455264983'UTRnovel0.36
UCECchr19455268363'UTRnovel0.93
UCECchr19455266493'UTRnovel0.24
UCECchr1945522766Nonsense_MutationNAR257*0.39
UCECchr1945524121Missense_Mutationrs759805062K312T0.3
UCECchr19455263083'UTRnovel0.48
UCECchr1945522353Frame_Shift_InsNAA167Rfs*880.29
UCECchr1945521364Missense_MutationNAV129A0.54
UCECchr1945522723Missense_MutationnovelE242D0.33
UCECchr1945522795Missense_MutationnovelE266D0.36
UCECchr1945518031Missense_Mutationrs529146911G94S0.36
UCECchr1945522786SilentnovelL263L0.28

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
CESCDEL0.07460.027508
KIRPDEL0.04510.054726
READDEL0.06670.23023
TGCTDEL0.28670.0046229
UCSDEL0.19640.12448

Survival Analysis
CancerP-value Q-value
THYM0.023

Kaplan-Meier Survival Analysis

KIRC0.0029

Kaplan-Meier Survival Analysis

SARC0.003

Kaplan-Meier Survival Analysis

MESO0.0002

Kaplan-Meier Survival Analysis

ACC0.027

Kaplan-Meier Survival Analysis

UCS0.018

Kaplan-Meier Survival Analysis

HNSC0.029

Kaplan-Meier Survival Analysis

LUSC0.017

Kaplan-Meier Survival Analysis

COAD0.034

Kaplan-Meier Survival Analysis

PAAD0.0044

Kaplan-Meier Survival Analysis

BLCA0.014

Kaplan-Meier Survival Analysis

LAML0.013

Kaplan-Meier Survival Analysis

GBM0.013

Kaplan-Meier Survival Analysis

LIHC0.00013

Kaplan-Meier Survival Analysis

DLBC0.039

Kaplan-Meier Survival Analysis

LGG0.00011

Kaplan-Meier Survival Analysis

LUAD0.02

Kaplan-Meier Survival Analysis

UVM0.0087

Kaplan-Meier Survival Analysis

OV0.026

Kaplan-Meier Survival Analysis

Drugs

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Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBPome
  • Literatures
  • Expression
  • Transcripts
  • Gene Model
  • Pathways
  • Phenotypes
  • PPI
  • Gene Ontology
Description
Ensembl ID
ENSG00000125753 (Gene tree)
Gene ID
7408
Gene Symbol
VASP
Alias
N
Full Name
vasodilator stimulated phosphoprotein
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Plus strand
Length
20,411 bases
Position
chr19:45,506,579-45,526,989
Accession
12652
RBP type
non-canonical RBP
Summary
Vasodilator-stimulated phosphoprotein (VASP) is a member of the Ena-VASP protein family. Ena-VASP family members contain an EHV1 N-terminal domain that binds proteins containing E/DFPPPPXD/E motifs and targets Ena-VASP proteins to focal adhesions. In the mid-region of the protein, family members have a proline-rich domain that binds SH3 and WW domain-containing proteins. Their C-terminal EVH2 domain mediates tetramerization and binds both G and F actin. VASP is associated with filamentous actin formation and likely plays a widespread role in cell adhesion and motility. VASP may also be involved in the intracellular signaling pathways that regulate integrin-extracellular matrix interactions. VASP is regulated by the cyclic nucleotide-dependent kinases PKA and PKG. [provided by RefSeq, Jul 2008]
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & MCF10A2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & U2OS2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
16531412Migfilin interacts with vasodilator-stimulated phosphoprotein (VASP) and regulates VASP localization to cell-matrix adhesions and migration.J Biol Chem2006 May 5Zhang Y-
22395610Dimensional and temporal controls of three-dimensional cell migration by zyxin and binding partners.Nat Commun2012 Mar 6Fraley SIdoi: 10.1038/ncomms1711.
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000590603VASP-210388-ENSP0000046777335 (aa)-K7EQD0
ENST00000586014VASP-2021725-ENSP00000467005103 (aa)-K7ENL7
ENST00000592139VASP-211424-ENSP0000046474246 (aa)-K7EIG8
ENST00000587444VASP-204240--- (aa)--
ENST00000590459VASP-209405--- (aa)--
ENST00000588482VASP-207804-ENSP00000466319183 (aa)-K7EM16
ENST00000588463VASP-206655--- (aa)--
ENST00000589627VASP-208696-ENSP0000046706159 (aa)-K7ENR7
ENST00000588273VASP-205318--- (aa)--
ENST00000245932VASP-2012305XM_005259199ENSP00000245932380 (aa)XP_005259256P50552
ENST00000586619VASP-203655--- (aa)--
Gene Model
Click here to download ENSG00000125753's gene model file
Pathways
Pathway IDPathway NameSource
hsa04015Rap1 signaling pathwayKEGG
hsa04022cGMP-PKG signaling pathwayKEGG
hsa04510Focal adhesionKEGG
hsa04530Tight junctionKEGG
hsa04611Platelet activationKEGG
hsa04666Fc gamma R-mediated phagocytosisKEGG
hsa04670Leukocyte transendothelial migrationKEGG
Phenotypes
ensgIDTraitpValuePubmed ID
ENSG00000125753Blood Pressure4.2400762E-005-
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000125753's network

* RBP PPI network refers to all genes directly bind to RBP
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0001843neural tube closure-IEAProcess
GO:0003779actin binding-IEAFunction
GO:0005515protein binding8836115.16189514.16631741.16940418.17599063.20195357.21423205.21911467.23153535.24076653.25416956.IPIFunction
GO:0005522profilin binding17914456.IPIFunction
GO:0005829cytosol-IDAComponent
GO:0005829cytosol-TASComponent
GO:0005886plasma membrane-IDAComponent
GO:0005923bicellular tight junction-IEAComponent
GO:0005925focal adhesion21423176.HDAComponent
GO:0005925focal adhesion-IDAComponent
GO:0007411axon guidance-TASProcess
GO:0008154actin polymerization or depolymerization-IEAProcess
GO:0015629actin cytoskeleton7828592.TASComponent
GO:0017124SH3 domain binding-IEAFunction
GO:0030838positive regulation of actin filament polymerization23153535.IDAProcess
GO:0031258lamellipodium membrane-IEAComponent
GO:0031527filopodium membrane-IEAComponent
GO:0034329cell junction assembly-TASProcess
GO:0045296cadherin binding25468996.HDAFunction
GO:0051289protein homotetramerization-IEAProcess
GO:0070062extracellular exosome19056867.20458337.HDAComponent
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