EuRBPDB

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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Differential Expression

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
ACCchr2057611776Silentrs370372910H275H0.19
BLCAchr2057611790Missense_MutationNAE271Q0.17
BLCAchr2057614969SilentnovelV140V0.06
BLCAchr2057616398SilentnovelV35V0.24
BLCAchr2057613260Missense_MutationnovelQ191H0.28
BLCAchr2057604580Missense_MutationnovelG428A0.06
BLCAchr2057604728Frame_Shift_DelnovelD370Rfs*380.14
BLCAchr2057604635Missense_MutationnovelE410Q0.36
BRCAchr2057604702SilentnovelP387P0.09
BRCAchr20576044473'UTRnovel0.26
BRCAchr2057604742Missense_MutationNAR374I0.3
BRCAchr2057613318Missense_MutationnovelR172K0.09
CESCchr2057616416SilentNAV29V0.46
CESCchr20576042733'UTRrs5766208780.43
CESCchr2057611903Missense_MutationnovelS233L0.39
COADchr2057611874Missense_MutationNAG243R0.13
COADchr2057614965Nonsense_Mutationrs754746401R142*0.33
COADchr2057610337Missense_Mutationrs147660947S302L0.14
COADchr2057615034Missense_MutationnovelD119Y0.23
COADchr2057613331Splice_SitenovelX168_splice0.26
COADchr2057615016Missense_MutationnovelA125T0.26
COADchr2057610288Silentrs146958594A318A0.13
COADchr2057614997Missense_MutationnovelA131V0.33
COADchr2057613068Intronnovel0.39
COADchr2057610336Silentrs374383138S302S0.33
COADchr2057604587Nonsense_MutationNAG426*0.58
COADchr2057611857SilentNAP248P0.11
COADchr2057604755Missense_MutationNAD370N0.34
COADchr2057611813Missense_MutationNAR263L0.1
COADchr20576045043'UTRnovel0.32
COADchr2057614977Missense_MutationnovelK138E0.18
COADchr2057613069Intronnovel0.33
DLBCchr2057620267Missense_MutationnovelR10K0.4
ESCAchr2057613049Intronnovel0.13
ESCAchr2057604761Missense_Mutationrs762891234P368S0.49
GBMchr2057613253Missense_MutationnovelP194A0.06
GBMchr2057613243Nonsense_MutationnovelW197*0.19
GBMchr20576044843'UTRnovel0.19
GBMchr2057604767Missense_Mutationrs141295310R366C0.36
GBMchr2057613320SilentnovelG171G0.12
GBMchr2057616346Missense_MutationNAK53Q0.35z-alpha
GBMchr2057615533Missense_MutationNAP103S0.3
HNSCchr2057613331Splice_SitenovelX168_splice0.41
HNSCchr2057614909SilentnovelK160K0.31
HNSCchr2057616277Missense_MutationnovelE76K0.29
HNSCchr2057614890Missense_MutationnovelP167S0.33
HNSCchr2057614984Missense_MutationnovelR135S0.42
KICHchr2057610249Silentrs186925447D331D0.46
KIRCchr2057610199Missense_Mutationrs752942618G348D0.37
KIRCchr20576203245'UTRnovel0.44
KIRPchr2057620273Missense_Mutationrs762116149P8L0.03
LIHCchr2057604573SilentNA*430*0.24
LIHCchr2057613261Missense_MutationnovelQ191L0.21
LUADchr2057616290SilentNAT71T0.11
LUADchr2057613176SilentNAV219V0.87
LUADchr2057604619Missense_Mutationrs764079652V415A0.35
LUADchr2057611779SilentnovelL274L0.11
LUADchr2057611752SilentNAA283A0.54
LUADchr2057613212Missense_MutationnovelQ207H0.05
LUADchr2057616261Missense_MutationnovelL81Q0.31
LUADchr2057610255SilentnovelL329L0.12
LUADchr2057604598Missense_MutationnovelG422E0.09
LUADchr20576044263'UTRnovel0.14
LUADchr2057611769Missense_MutationnovelP278S0.87
LUSCchr20576045193'UTRnovel0.19
LUSCchr2057616433Missense_MutationnovelE24Q0.07z-alpha
LUSCchr2057604677Missense_MutationnovelL396M0.35
LUSCchr2057604605Missense_MutationnovelH420Y0.33
LUSCchr2057613179SilentnovelT218T0.24
LUSCchr2057611837Missense_MutationnovelH255L0.19
LUSCchr2057610280Missense_MutationNAR321K0.57
LUSCchr2057611839SilentNAI254I0.24
LUSCchr2057615530Missense_MutationNAQ104E0.19
LUSCchr2057610175Missense_Mutationrs77921447G356V0.3
LUSCchr2057615544Missense_MutationnovelE99G0.38
LUSCchr2057613143Intronnovel0.37
LUSCchr20576044343'UTRnovel0.6
LUSCchr2057604598Missense_MutationnovelG422A0.3
LUSCchr2057614984SilentnovelR135R0.28
OVchr2057610327SilentnovelA305A0.32
OVchr2057616290SilentNAT71T0.1
OVchr2057613210Missense_MutationNAI208T0.37
OVchr2057613212Missense_MutationnovelQ207H0.04
OVchr2057610309SilentnovelG311G0.07
OVchr2057604627SilentNAS412S0.21
OVchr2057615004Missense_Mutationrs141977359A129T0.35
OVchr2057614945Missense_MutationNAK148N0.35
OVchr20576043183'UTRnovel0.08
PAADchr2057611793Missense_MutationnovelN270H0.14
PRADchr2057610336Silentrs374383138S302S0.06
READchr2057610264Silentrs143130163S326S0.06
READchr2057604767Missense_Mutationrs141295310R366C0.16
READchr2057615018Missense_MutationNAR124M0.1
READchr2057610307Missense_MutationNAT312N0.16
SARCchr2057616373Missense_Mutationrs772926217E44K0.16z-alpha
SARCchr2057611768Missense_MutationnovelP278Q0.07
SKCMchr2057610168SilentnovelG358G0.34
SKCMchr2057614964Missense_Mutationrs751395998R142Q0.44
SKCMchr2057604602Missense_MutationNAE421K0.32
SKCMchr2057611731SilentNAP290P0.59
SKCMchr2057610301Missense_MutationnovelP314L0.56
SKCMchr2057615558SilentNAA94A0.27
SKCMchr2057610170Missense_MutationNAG358R0.24
SKCMchr2057610171Silentrs745740982E357E0.24
SKCMchr2057615001Nonsense_MutationnovelQ130*0.16
SKCMchr2057615002SilentnovelA129A0.16
SKCMchr20576203585'UTRnovel0.4
SKCMchr2057615513Splice_RegionnovelR109R0.34
SKCMchr2057616368SilentNAL45L0.26
SKCMchr2057616407SilentNAA32A0.14
SKCMchr2057604764Missense_Mutationrs751287186R367C0.1
SKCMchr2057604687SilentNAL392L0.06
SKCMchr2057616426Missense_MutationNAG26D0.13z-alpha
SKCMchr2057616311SilentnovelA64A0.48
SKCMchr20576045203'UTRnovel0.48
SKCMchr2057613126Intronnovel0.52
SKCMchr2057615005Silentrs774963938I128I0.48
SKCMchr2057616318Missense_Mutationrs368022689S62F0.33
SKCMchr2057616344Missense_MutationnovelK53N0.45z-alpha
SKCMchr2057614900SilentNAT163T0.72
SKCMchr2057604727Missense_Mutationrs748618471R379Q0.34
SKCMchr2057615058Missense_Mutationrs764212417E111K0.29
SKCMchr2057613122Intronnovel0.23
SKCMchr2057616363Missense_MutationNAQ47R0.41z-alpha
SKCMchr2057616394Missense_MutationnovelE37K0.33z-alpha
STADchr2057613114Intronnovel0.11
STADchr2057604758Missense_Mutationrs765287829A369T0.32
STADchr2057615515Missense_Mutationrs746334067R109W0.11
STADchr2057614964Missense_Mutationrs751395998R142Q0.37
STADchr2057614932Frame_Shift_InsnovelL153Sfs*50.21
STADchr2057613182SilentnovelQ217Q0.24
STADchr20576044833'UTRnovel0.17
STADchr2057614965Nonsense_Mutationrs754746401R142*0.26
STADchr20576045293'UTRnovel0.24
UCECchr20576203515'UTRnovel0.38
UCECchr2057613203Silentrs368487372H210H0.35
UCECchr2057616280Missense_MutationNAG75C0.49
UCECchr2057611754Missense_MutationnovelA283T0.52
UCECchr2057616296Silentrs765740931G69G0.4
UCECchr20576204695'UTRnovel0.24
UCECchr2057615061Splice_SiteNAX110_splice0.16
UCECchr2057613113Intronrs1848610140.46
UCECchr2057615535Missense_MutationnovelG102D0.47
UCECchr2057613203Silentrs368487372H210H0.38
UCECchr2057616329SilentnovelV58V0.06
UCECchr2057620269SilentNAG9G0.19
UCECchr2057604654SilentnovelN403N0.15
UCECchr2057613269Missense_MutationNAM188I0.41
UCECchr2057616452Missense_MutationnovelR17S0.47z-alpha
UCECchr20576204445'UTRnovel0.31
UCECchr20576045043'UTRnovel0.56
UCECchr2057611829Nonsense_MutationNAQ258*0.14
UCECchr2057610265Nonsense_Mutationrs148258013S326*0.39
UCECchr2057613143Intronnovel0.25
UCECchr2057616312Missense_MutationnovelA64V0.2
UCECchr20576203865'UTRnovel0.29
UCECchr2057604766Missense_Mutationrs754610408R366H0.31
UCECchr20576044713'UTRnovel0.37
UCECchr2057613242Nonsense_MutationNAW197*0.3
UCECchr20576043873'UTRnovel0.39
UCECchr2057610280Missense_MutationnovelR321I0.54
UCECchr2057613273Missense_MutationnovelN187S0.5
UCECchr2057616383SilentnovelA40A0.4
UCECchr2057610325Missense_MutationnovelR306I0.2
UCECchr2057615534SilentnovelG102G0.42
UCECchr20576045253'UTRnovel0.46
UCECchr2057610244Missense_MutationnovelT333I0.41
UCECchr20576043963'UTRnovel0.42
UCECchr2057604758Missense_Mutationrs765287829A369T0.29
UCECchr20576045603'UTRrs3767910220.32
UCECchr20576203225'UTRnovel0.21
UCECchr2057611840Missense_MutationnovelI254T0.43
UCECchr20576203625'UTRnovel0.21
UCECchr2057614976Missense_MutationnovelK138T0.5
UCECchr20576044323'UTRnovel0.17
UCECchr2057610265Missense_Mutationrs148258013S326L0.36
UCECchr2057613133Intronnovel0.31
UCECchr20576203195'UTRrs3720431190.33
UCECchr2057610280Missense_MutationnovelR321I0.45

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
PRADAMP0.05490.07085
SARCAMP0.3230.033553
SKCMAMP0.44960.058021

Survival Analysis
CancerP-value Q-value
THYM0.0019

Kaplan-Meier Survival Analysis

KIRC0.0001

Kaplan-Meier Survival Analysis

SARC0.011

Kaplan-Meier Survival Analysis

MESO0.0035

Kaplan-Meier Survival Analysis

HNSC0.00057

Kaplan-Meier Survival Analysis

LUSC0.042

Kaplan-Meier Survival Analysis

BRCA0.033

Kaplan-Meier Survival Analysis

LAML0.0089

Kaplan-Meier Survival Analysis

LIHC0.031

Kaplan-Meier Survival Analysis

LGG0.0001

Kaplan-Meier Survival Analysis

LUAD0.031

Kaplan-Meier Survival Analysis

UVM0.00083

Kaplan-Meier Survival Analysis

OV0.0033

Kaplan-Meier Survival Analysis

Drugs

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Input Drug :


Input Cell Line :


Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBDs
  • Literatures
  • Expression
  • Transcripts
  • Gene Model
  • Pathways
  • Phenotypes
  • GWAS
  • PPI
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000124256 (Gene tree)
Gene ID
81030
Gene Symbol
ZBP1
Alias
dJ718J7.3|DLM1|DLM-1|DAI|C20orf183
Full Name
Z-DNA binding protein 1
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Minus strand
Length
16,731 bases
Position
chr20:57,603,846-57,620,576
Accession
16176
RBP type
canonical RBP
Summary
This gene encodes a Z-DNA binding protein. The encoded protein plays a role in the innate immune response by binding to foreign DNA and inducing type-I interferon production. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]
RNA binding domains(RBDs)
Protein IDDomain Pfam IDE-value Domain number Total number
ENSP00000440552z-alphaPF02295.171.3e-1312
ENSP00000440552z-alphaPF02295.171.3e-1322
ENSP00000360215z-alphaPF02295.177.2e-1311

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
28716805Sensing of viral and endogenous RNA by ZBP1/DAI induces necroptosis.EMBO J2017 Sep 1Maelfait Jdoi: 10.15252/embj.201796476
20456414Nucleic acid sensing receptors in systemic lupus erythematosus: development of novel DNA- and/or RNA-like analogues for treating lupus.Clin Exp Immunol2010 AugLenert Pdoi: 10.1111/j.1365-2249.2010.04176.x
11842111Complex regulation of the human gene for the Z-DNA binding protein DLM-1.Nucleic Acids Res2002 Feb 15Rothenburg S-
16990255ZBP1 subcellular localization and association with stress granules is controlled by its Z-DNA binding domains.Nucleic Acids Res2006Deigendesch N-
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000395822ZBP1-2022073-ENSP00000379167354 (aa)-Q9H171
ENST00000461547ZBP1-2054213--- (aa)--
ENST00000480037ZBP1-2061737--- (aa)--
ENST00000538947ZBP1-207589--- (aa)--
ENST00000546110ZBP1-209558--- (aa)--
ENST00000432548ZBP1-203573--- (aa)--
ENST00000453793ZBP1-204357-ENSP00000404620119 (aa)-H0Y6D1
ENST00000371173ZBP1-2012195XM_011529057ENSP00000360215429 (aa)XP_011527359Q9H171
ENST00000541799ZBP1-2081041XM_017028086ENSP00000440552248 (aa)XP_016883575Q9H171
Gene Model
Click here to download ENSG00000124256's gene model file
Pathways
Pathway IDPathway NameSource
hsa04217NecroptosisKEGG
hsa04623Cytosolic DNA-sensing pathwayKEGG
Phenotypes
ensgIDTraitpValuePubmed ID
ENSG00000124256Body Fat Distribution6.1800000E-005-
ENSG00000124256Body Fat Distribution3.4780000E-005-
ENSG00000124256Coronary Disease8.0190000E-005-
ENSG00000124256Hippocampus2E-619668339
GWAS
ensgIDSNPChromosomePositionSNP-risk TraitPubmedID95% CIOr or BEAT EFO ID
ENSG00000124256rs20731452057615578?Hippocampal atrophy19668339EFO_0005039
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000124256's network

* RBP PPI network refers to all genes directly bind to RBP
Orthologs
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000124256ZBP19062.054ENSAMEG00000012704-10057.552Ailuropoda_melanoleuca
ENSG00000124256ZBP19981.882ENSANAG00000038003ZBP110082.258Aotus_nancymaae
ENSG00000124256ZBP110080.653ENSCJAG00000019094ZBP110080.653Callithrix_jacchus
ENSG00000124256ZBP19256.710ENSCAFG00000023783ZBP19850.233Canis_familiaris
ENSG00000124256ZBP19852.225ENSCAFG00020022005ZBP19552.225Canis_lupus_dingo
ENSG00000124256ZBP19156.388ENSCHIG00000006747-8654.617Capra_hircus
ENSG00000124256ZBP19454.831ENSCPOG00000008569ZBP19854.831Cavia_porcellus
ENSG00000124256ZBP110079.720ENSCCAG00000009469ZBP19979.720Cebus_capucinus
ENSG00000124256ZBP19889.048ENSCATG00000013143ZBP110089.048Cercocebus_atys
ENSG00000124256ZBP19556.057ENSCLAG00000012154ZBP19955.582Chinchilla_lanigera
ENSG00000124256ZBP19234.874ENSCPBG00000023941ZBP18230.376Chrysemys_picta_bellii
ENSG00000124256ZBP110089.548ENSCANG00000035951ZBP110089.548Colobus_angolensis_palliatus
ENSG00000124256ZBP19648.821ENSCGRG00001015544Zbp19648.585Cricetulus_griseus_chok1gshd
ENSG00000124256ZBP19648.471ENSCGRG00000002294Zbp19548.235Cricetulus_griseus_crigri
ENSG00000124256ZBP19356.436ENSDNOG00000002438-9054.455Dasypus_novemcinctus
ENSG00000124256ZBP19454.390ENSEASG00005023257ZBP19654.390Equus_asinus_asinus
ENSG00000124256ZBP19454.146ENSECAG00000017185ZBP19654.146Equus_caballus
ENSG00000124256ZBP19148.230ENSEEUG00000002058-9946.647Erinaceus_europaeus
ENSG00000124256ZBP18862.844ENSFCAG00000000420-9562.844Felis_catus
ENSG00000124256ZBP110097.902ENSGGOG00000011001ZBP110097.902Gorilla_gorilla
ENSG00000124256ZBP19888.810ENSMFAG00000030920ZBP110088.810Macaca_fascicularis
ENSG00000124256ZBP19888.571ENSMMUG00000022588ZBP110088.571Macaca_mulatta
ENSG00000124256ZBP19888.571ENSMNEG00000043957ZBP110088.571Macaca_nemestrina
ENSG00000124256ZBP110084.382ENSMLEG00000031509ZBP110084.382Mandrillus_leucophaeus
ENSG00000124256ZBP19550.204ENSMAUG00000001095Zbp19941.084Mesocricetus_auratus
ENSG00000124256ZBP19459.829ENSMICG00000046613ZBP110050.339Microcebus_murinus
ENSG00000124256ZBP19848.284ENSMOCG00000019061Zbp19848.284Microtus_ochrogaster
ENSG00000124256ZBP19646.667MGP_CAROLIEiJ_G0024748Zbp19646.667Mus_caroli
ENSG00000124256ZBP19647.017ENSMUSG00000027514Zbp19547.017Mus_musculus
ENSG00000124256ZBP19050.649MGP_PahariEiJ_G0026189-8547.712Mus_pahari
ENSG00000124256ZBP19646.778MGP_SPRETEiJ_G0025668Zbp19546.778Mus_spretus
ENSG00000124256ZBP19753.302ENSMPUG00000006670-9453.302Mustela_putorius_furo
ENSG00000124256ZBP19050.222ENSMLUG00000017020-9747.059Myotis_lucifugus
ENSG00000124256ZBP19651.415ENSNGAG00000023407Zbp19653.066Nannospalax_galili
ENSG00000124256ZBP110091.142ENSNLEG00000007069ZBP110091.142Nomascus_leucogenys
ENSG00000124256ZBP19060.352ENSOGAG00000014671ZBP110055.990Otolemur_garnettii
ENSG00000124256ZBP19155.947ENSOARG00000017418-7655.685Ovis_aries
ENSG00000124256ZBP110097.436ENSPPAG00000037949ZBP110097.436Pan_paniscus
ENSG00000124256ZBP19260.870ENSPPRG00000011275-9860.776Panthera_pardus
ENSG00000124256ZBP19262.174ENSPTIG00000011495-9862.069Panthera_tigris_altaica
ENSG00000124256ZBP110097.902ENSPTRG00000013665ZBP110097.902Pan_troglodytes
ENSG00000124256ZBP19889.286ENSPANG00000023211ZBP110089.286Papio_anubis
ENSG00000124256ZBP19949.543ENSPEMG00000016060Zbp19948.970Peromyscus_maniculatus_bairdii
ENSG00000124256ZBP110094.406ENSPPYG00000011165ZBP110094.406Pongo_abelii
ENSG00000124256ZBP19761.205ENSPCOG00000027415ZBP19860.964Propithecus_coquereli
ENSG00000124256ZBP18857.339ENSPVAG00000014691-9654.201Pteropus_vampyrus
ENSG00000124256ZBP19746.604ENSRNOG00000006314Zbp19846.370Rattus_norvegicus
ENSG00000124256ZBP110089.744ENSRBIG00000044740ZBP110089.744Rhinopithecus_bieti
ENSG00000124256ZBP110089.277ENSRROG00000038526ZBP110089.277Rhinopithecus_roxellana
ENSG00000124256ZBP19980.378ENSSBOG00000032730ZBP19981.466Saimiri_boliviensis_boliviensis
ENSG00000124256ZBP19162.115ENSTBEG00000006578ZBP110060.218Tupaia_belangeri
ENSG00000124256ZBP19158.850ENSTTRG00000000687-9553.353Tursiops_truncatus
ENSG00000124256ZBP19061.607ENSUAMG00000019777ZBP18358.760Ursus_americanus
ENSG00000124256ZBP19954.167ENSUMAG00000002600ZBP19553.935Ursus_maritimus
ENSG00000124256ZBP19851.991ENSVVUG00000017189-9551.054Vulpes_vulpes
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0003677DNA binding21873635.IBAFunction
GO:0003677DNA binding17618271.IDAFunction
GO:0003692left-handed Z-DNA binding11842111.NASFunction
GO:0003723RNA binding-IEAFunction
GO:0003726double-stranded RNA adenosine deaminase activity-IEAFunction
GO:0005515protein binding19590578.IPIFunction
GO:0005634nucleus21873635.IBAComponent
GO:0005634nucleus19158679.IDAComponent
GO:0005737cytoplasm19158679.IDAComponent
GO:0005829cytosol17618271.IDAComponent
GO:0005829cytosol-TASComponent
GO:0008150biological_process-NDProcess
GO:0032479regulation of type I interferon production-TASProcess
GO:0032481positive regulation of type I interferon production-TASProcess
GO:0045087innate immune response-IEAProcess
GO:0060340positive regulation of type I interferon-mediated signaling pathway21873635.IBAProcess
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