EuRBPDB

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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
23258480Argonaute2 promotes tumor metastasis by way of up-regulating focal adhesion kinase expression in hepatocellular carcinoma.Hepatology2013 MayCheng Ndoi: 10.1002/hep.26202.
20146808Argonaute proteins: potential biomarkers for human colon cancer.BMC Cancer2010 Feb 10Li Ldoi: 10.1186/1471-2407-10-38.
23201202Overexpression of human Argonaute2 inhibits cell and tumor growth.Biochim Biophys Acta2013 MarZhang X-
18981691[Antineovascular gene therapy by Ago2 knockdown].Yakugaku Zasshi2008 NovHatanaka K-
24935600Increased argonaute 2 expression in gliomas and its association with tumor progression and poor prognosis.Asian Pac J Cancer Prev2014Feng B-
18787018Argonaute-2 expression is regulated by epidermal growth factor receptor and mitogen-activated protein kinase signaling and correlates with a transformed phenotype in breast cancer cells.Endocrinology2009 JanAdams BDdoi: 10.1210/en.2008-0984
22025453Expression levels of the microRNA maturing microprocessor complex component DGCR8 and the RNA-induced silencing complex (RISC) components argonaute-1, argonaute-2, PACT, TARBP1, and TARBP2 in epithelial skin cancer.Mol Carcinog2012 NovSand Mdoi: 10.1002/mc.20861
25135428Down-regulation of Dicer and Ago2 is associated with cell proliferation and apoptosis in prostate cancer.Tumour Biol2014 NovBian XJdoi: 10.1007/s13277-014-2462-3
24805183Loss of miR-100 enhances migration, invasion, epithelial-mesenchymal transition and stemness properties in prostate cancer cells through targeting Argonaute 2.Int J Oncol2014 JulWang Mdoi: 10.3892/ijo.2014.2413
20198652Somatic mutations and losses of expression of microRNA regulation-related genes AGO2 and TNRC6A in gastric and colorectal cancers.J Pathol2010 JunKim MSdoi: 10.1002/path.2683.
19723326mRNA expression profiles show differential regulatory effects of microRNAs between estrogen receptor-positive and estrogen receptor-negative breast cancer.Genome Biol2009Cheng Cdoi: 10.1186/gb-2009-10-9-r90
28954383Long non-coding RNA CASC7 inhibits the proliferation and migration of colon cancer cells via inhibiting microRNA-21.Biomed Pharmacother2017 NovZhang Zdoi: 10.1016/j.biopha.2017.09.052
29017520The nuclear receptor ERβ engages AGO2 in regulation of gene transcription, RNA splicing and RISC loading.Genome Biol2017 Oct 6Tarallo Rdoi: 10.1186/s13059-017-1321-0.
30476917Nuclear Translocation of Argonaute 2 in Cytokine-Induced Senescence.Cell Physiol Biochem2018Rentschler Mdoi: 10.1159/000495490

Differential Expression

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
BLCAchr8140547620SilentnovelV532V0.19
BLCAchr8140562502Missense_MutationnovelE157K0.22
BLCAchr8140539433Frame_Shift_DelnovelA686Pfs*90.19
BLCAchr8140539424Nonsense_MutationNAE689*0.07
BLCAchr8140541260SilentnovelV646V0.27
BLCAchr8140551422Silentrs559356764A428A0.15
BLCAchr8140572862Missense_MutationnovelG96S0.14
BLCAchr8140572812Missense_MutationnovelK112N0.12
BLCAchr8140544254Missense_MutationnovelH600Y0.4
BLCAchr8140549208Silentrs779866243A498A0.14
BLCAchr8140562598Missense_MutationnovelD125N0.19
BLCAchr8140558538Missense_MutationNAM275I0.21
BLCAchr8140551392SilentNAR438R0.16
BLCAchr8140557206SilentNAT303T0.43
BRCAchr8140557184Missense_MutationNAY311H0.41
BRCAchr8140539365Missense_MutationnovelQ708H0.73
BRCAchr8140539340Missense_MutationNAC717S0.27
BRCAchr8140539324Missense_MutationNAE722V0.13
BRCAchr8140551328Missense_MutationNAR460C0.14
BRCAchr8140556210Missense_MutationNAT368S0.22
BRCAchr8140560415Missense_MutationNAS205F0.24
BRCAchr81405319533'UTRnovel0.47
BRCAchr8140539349Missense_MutationNAR714W0.33
BRCAchr81405320163'UTRnovel0.11
CESCchr8140532581Nonsense_MutationNAW769*0.44PAZ
CESCchr8140555915Missense_MutationNAS417Y0.28
CESCchr8140562616SilentNAL119L0.24
CESCchr81405315393'UTRnovel0.31
CESCchr81405317833'UTRrs7604304340.4
CESCchr8140562512Silentrs746068311S153S0.33
CESCchr8140547596Silentrs751224339L540L0.29
CESCchr8140562476SilentnovelV165V0.46
CESCchr8140549241SilentNAG487G0.15
CESCchr8140572857Missense_MutationnovelR97S0.56
CHOLchr8140556248Frame_Shift_DelnovelK355Nfs*20.4
COADchr8140555897Missense_MutationnovelR423K0.43
COADchr8140555900Frame_Shift_DelnovelG422Afs*460.4
COADchr8140556248Frame_Shift_DelnovelK355Nfs*20.21
COADchr8140557206SilentNAT303T0.43
COADchr8140549209Missense_MutationnovelA498V0.07
COADchr8140535501SilentNAF746F0.47
COADchr8140585289SilentNAP15P0.39
COADchr8140559516Silentrs767782553A223A0.37
COADchr8140539426Missense_MutationnovelR688H0.16
COADchr8140585119Missense_MutationnovelR72M0.1
COADchr8140539428Frame_Shift_InsNAR688Pfs*20.33
COADchr8140562482Silentrs76003517D163D0.23
COADchr8140541228Missense_MutationNAT657M0.3
COADchr8140549237Missense_MutationNAP489S0.38
COADchr8140532418Splice_Regionrs777138988D823D0.39
COADchr8140558539Missense_MutationNAM275T0.11
COADchr8140549218Missense_MutationNAA495V0.15
COADchr8140544289Missense_MutationnovelQ588R0.11
COADchr8140551417Missense_MutationNAP430L0.38
COADchr81405319503'UTRnovel0.32
ESCAchr8140585293Missense_Mutationrs201542441P14L0.6
ESCAchr8140557220Missense_MutationnovelE299K0.31
GBMchr8140547607Missense_MutationnovelD537Y0.22
GBMchr8140555998Missense_MutationnovelN389K0.16
GBMchr8140557106Missense_MutationnovelT337S1
GBMchr8140585198Missense_MutationnovelE46K0.09
GBMchr8140560408SilentNAR207R0.36
GBMchr8140559454Missense_MutationnovelE244G0.09
GBMchr8140547563Silentrs529772374N551N0.4
GBMchr8140572837Frame_Shift_InsnovelM104Sfs*540.15
GBMchr8140549198Missense_MutationnovelE502K0.15
GBMchr8140535477SilentnovelA754A0.13
GBMchr81405319323'UTRnovel0.71
HNSCchr8140551368Silentrs142051728I446I0.38
HNSCchr8140547566Missense_MutationnovelK550N0.26
HNSCchr8140541324Missense_MutationNAY625C0.15
HNSCchr8140555985Missense_MutationnovelV394I0.11
HNSCchr8140558498Missense_Mutationrs752866847A289S0.44
HNSCchr8140549278Missense_MutationnovelR475K0.15
HNSCchr8140560473Missense_Mutationrs764154303E186K0.39
HNSCchr8140562617Silentrs377556379T118T0.17
HNSCchr8140532598Silentrs746273496S763S0.31
KIRCchr8140539319Splice_SiteNAX723_splice0.29
KIRCchr8140555970Missense_MutationNAI399V0.11
KIRCchr8140535489SilentNAL750L0.47
KIRCchr8140549252Missense_MutationNAP484A0.2
KIRCchr8140549253Missense_MutationNAM483I0.19
KIRCchr8140549114Missense_MutationNAA530T0.13
KIRPchr8140547597Missense_MutationNAL540P0.34
LGGchr8140585289Silentrs141930048P15P0.36
LGGchr8140541250Missense_MutationnovelL650I0.31
LIHCchr8140585232Silentrs781495805S34S0.25
LIHCchr8140549272Missense_MutationnovelI477N0.68
LUADchr8140557146SilentNAP323P0.08
LUADchr8140544242Missense_MutationNAG604R0.06
LUADchr8140549212Missense_MutationNAG497A0.09
LUADchr8140539421Missense_MutationNAA690T0.22
LUADchr8140547518Missense_MutationnovelK566N0.08
LUADchr8140539348Missense_MutationnovelR714L0.09
LUADchr8140532059SilentNAT855T0.19
LUADchr8140560487Missense_MutationNAF181S0.11
LUADchr8140539370Missense_MutationNAV707M0.23
LUADchr8140572914Missense_MutationNAM78I0.07
LUADchr8140585211Missense_MutationNAQ41H0.17
LUADchr8140557205Missense_MutationNAV304M0.15
LUADchr8140557123Missense_MutationnovelG331V0.15
LUADchr8140557231Missense_MutationnovelP295L0.48
LUADchr8140535487Missense_MutationNAC751F0.11PAZ
LUSCchr8140572833SilentNAP105P0.42
LUSCchr81405319933'UTRnovel0.45
LUSCchr8140532570Missense_Mutationrs777477236R773C0.13PAZ
LUSCchr81405319863'UTRnovel0.17
LUSCchr8140547501Frame_Shift_DelnovelG572Efs*30.39
LUSCchr8140562491SilentnovelQ160Q0.07
LUSCchr8140549142SilentNAV520V0.2
LUSCchr8140572934Splice_SiteNAX72_splice0.3
OVchr8140557095SilentnovelP340P0.14
OVchr8140556226Missense_MutationnovelT363S0.09
OVchr8140547476SilentnovelP580P0.07
OVchr8140539335SilentnovelT718T0.05
OVchr8140557094SilentnovelL341L0.2
OVchr8140547525Missense_MutationnovelC564S0.35
PAADchr8140539407Nonsense_MutationnovelE695Tfs*110.09
PRADchr8140541338SilentnovelA620A0.36
PRADchr8140557149SilentNAY322Y0.04
PRADchr8140562539Silentrs149363419H144H0.3
PRADchr8140560443Nonsense_MutationnovelR196*0.13
READchr8140555934Missense_MutationNAR411W0.17
READchr8140539385Missense_MutationnovelI702L0.23
READchr8140547625Missense_MutationnovelE531K0.17
SARCchr8140535519SilentnovelI740I0.17
SARCchr8140539374Silentrs2977471I705I0.33
SARCchr81405315713'UTRnovel0.46
SKCMchr8140532134SilentNAT830T0.14
SKCMchr8140562583Missense_MutationnovelV130M0.39
SKCMchr8140562584SilentnovelK129K0.39
SKCMchr8140532133Missense_MutationNAS831P0.25
SKCMchr8140560415Missense_MutationNAS205F0.59
SKCMchr8140555991Missense_MutationNAP392S0.08
SKCMchr8140572926Silentrs779523436I74I0.47
SKCMchr8140532570Missense_Mutationrs777477236R773C0.31PAZ
SKCMchr8140541334Missense_MutationNAP622S0.48
SKCMchr8140558490Silentrs759640414H291H0.21
SKCMchr8140532453Missense_MutationNAR812W0.68
SKCMchr8140549247SilentNAI485I0.48
SKCMchr8140585280SilentNAI18I0.59
SKCMchr8140562459Missense_MutationNAS171F0.48
SKCMchr8140532482Missense_MutationNAP802R0.5
SKCMchr8140562458SilentNAS171S0.23
SKCMchr8140585156Missense_MutationNAD60N0.09
SKCMchr8140532432In_Frame_DelnovelA810_V818del0.21
SKCMchr8140544282SilentnovelP590P0.06
SKCMchr8140555991Missense_MutationNAP392S0.32
SKCMchr8140562595Missense_Mutationrs756399814R126C0.51
SKCMchr8140547496Missense_MutationnovelV574L0.21
SKCMchr8140535501SilentNAF746F0.26
SKCMchr8140557096Missense_MutationNAP340L0.2
SKCMchr81405320153'UTRnovel0.32
SKCMchr8140556195Missense_MutationnovelP373L0.37
SKCMchr8140585214SilentNAL40L0.45
STADchr8140557105Missense_MutationNAT337S0.25
STADchr8140551393Missense_MutationNAR438Q0.23
STADchr8140551331Frame_Shift_DelNAQ459Sfs*90.27
STADchr8140560477Silentrs144947708A184A0.2
STADchr8140551328Missense_MutationNAR460C0.06
STADchr8140555944Silentrs747025316D407D0.2
STADchr8140551344Silentrs749725024A454A0.2
STADchr8140541356Splice_RegionnovelV614V0.26
STADchr8140532471Missense_MutationNAA806T0.12
STADchr8140585232Silentrs781495805S34S0.2
STADchr8140532107SilentnovelH839H0.22
STADchr8140555904Missense_MutationNAG421R0.15
STADchr8140585234Missense_MutationnovelS34P0.31
STADchr8140532577Silentrs751186251D770D0.12
STADchr8140549125Missense_Mutationrs760059271T526M0.13
STADchr8140551331Frame_Shift_DelNAQ459Sfs*90.07
STADchr8140551338Silentrs267601798F456F0.16
STADchr8140535501SilentNAF746F0.19
STADchr8140539346Missense_MutationNAL715F0.35
STADchr8140557171Missense_MutationNAR315M0.18
STADchr8140549210Frame_Shift_DelnovelA498Rfs*110.11
STADchr81405319603'UTRrs5488853510.2
STADchr8140541197SilentnovelY667Y0.33
STADchr8140555905Silentrs560546827Y420Y0.11
STADchr8140541319Missense_MutationNAA627T0.22
STADchr8140547593Frame_Shift_DelnovelM542Wfs*80.08
STADchr8140560473Missense_Mutationrs764154303E186K0.2
TGCTchr8140551394SilentnovelR438R0.06
THCAchr8140539395Silentrs761378470Y698Y0.09
THYMchr8140562527SilentnovelS148S0.35
THYMchr81405315463'UTRnovel0.35
UCECchr8140544301Missense_MutationnovelP584L0.45
UCECchr8140535501SilentNAF746F0.04
UCECchr8140572828Missense_Mutationrs773613021P107L0.39
UCECchr8140544296Missense_MutationnovelV586M0.41
UCECchr8140551310Missense_MutationnovelH466N0.2
UCECchr8140535501SilentNAF746F0.25
UCECchr8140560392Frame_Shift_DelnovelM213*0.32
UCECchr8140544245Frame_Shift_Insrs748399150A603Rfs*710.51
UCECchr8140547602Silentrs369817043T538T0.3
UCECchr8140551331Frame_Shift_DelNAQ459Sfs*90.44
UCECchr8140557145Frame_Shift_DelnovelH324Tfs*330.18
UCECchr8140532577Silentrs751186251D770D0.59
UCECchr8140532517Silentrs766096530Y790Y0.41
UCECchr8140560468SilentnovelG187G0.51
UCECchr8140539322Missense_MutationnovelR723W0.48PAZ
UCECchr8140555934Missense_MutationNAR411W0.3
UCECchr81405319453'UTRnovel0.3
UCECchr8140558546Missense_MutationnovelG273W0.41
UCECchr8140560501Frame_Shift_DelnovelV177Wfs*370.48
UCECchr8140559400Missense_MutationnovelI262S0.16
UCECchr8140556193Missense_MutationNAD374N0.39
UCECchr8140572872Silentrs371401188P92P0.27
UCECchr8140532511SilentNAR792R0.15
UCECchr8140560480SilentNAT183T0.24
UCECchr8140572926Silentrs779523436I74I0.49
UCECchr8140544212Splice_SitenovelX613_splice0.46
UCECchr81405317293'UTRnovel0.36
UCECchr8140551367Missense_MutationnovelE447K0.65
UCECchr8140572828Missense_Mutationrs773613021P107L0.23
UCECchr8140549237Missense_MutationNAP489S0.32
UCECchr8140532578Missense_MutationnovelD770G0.3PAZ
UCECchr8140556267Missense_MutationnovelG349E0.47
UCECchr8140560443Nonsense_MutationnovelR196*0.14
UCECchr8140557154Missense_MutationnovelR321C0.34
UCECchr8140559493Missense_MutationNAI231T0.3
UCECchr8140585182Missense_MutationnovelK51I0.44
UCECchr8140556243Missense_MutationnovelT357M0.36
UCECchr81405319883'UTRnovel0.42
UCECchr8140532484Silentrs774507490A801A0.51
UCECchr8140549218Missense_MutationNAA495V0.74
UCECchr8140541257Silentrs749601049R647R0.36
UCECchr8140544245Frame_Shift_Insrs748399150A603Rfs*710.48
UCECchr8140532421SilentnovelH822H0.14
UCECchr81405320263'UTRnovel0.35
UCECchr81405313013'UTRnovel0.44
UCECchr8140585199Silentrs202232727F45F0.54
UCECchr8140559392Splice_Regionnovel0.27
UCECchr8140549218Missense_MutationNAA495V0.39
UCECchr81405317673'UTRnovel0.22
UCECchr8140544245Frame_Shift_Insrs748399150A603Rfs*710.33
UCECchr8140585283Frame_Shift_DelnovelI18Sfs*1210.42
UCECchr8140541190Missense_MutationnovelG670S0.39
UCECchr8140562545SilentnovelA142A0.27
UCECchr8140558573Splice_SitenovelX264_splice0.38
UCECchr8140535501SilentNAF746F0.39
UCECchr8140541195Missense_MutationnovelR668H0.34
UCECchr81405318113'UTRnovel0.27
UCECchr8140549231Missense_MutationnovelF491I0.43
UCECchr8140556240Missense_MutationnovelD358G0.43
UCECchr81405319143'UTRnovel0.32
UCECchr8140541309Missense_MutationnovelR630H0.31
UCECchr8140539335SilentnovelT718T0.12
UCECchr8140572890Silentrs367630912I86I0.31
UCECchr8140585199Silentrs202232727F45F0.19
UCECchr8140544245Frame_Shift_Insrs748399150A603Rfs*710.39
UCECchr81405314913'UTRrs7962225200.44
UCECchr81405320263'UTRnovel0.18
UCECchr8140532513Missense_MutationNAR792C0.18
UCECchr8140551330Frame_Shift_InsNAQ459Pfs*2150.4
UCECchr8140560477Silentrs144947708A184A0.43
UCECchr81405313203'UTRnovel0.5
UCECchr8140549209Frame_Shift_InsnovelA498Gfs*1760.53
UCECchr8140532418Splice_Regionrs777138988D823D0.24
UCECchr8140535501SilentNAF746F0.49
UCECchr8140572890Silentrs367630912I86I0.49
UCECchr8140549210Frame_Shift_DelnovelA498Rfs*110.43
UCECchr8140541209SilentnovelR663R0.32
UCECchr8140541309Missense_MutationnovelR630H0.49
UCECchr8140549164Missense_Mutationrs758618443A513V0.64
UCECchr8140532065SilentNAL853L0.15
UCECchr8140544282SilentnovelP590P0.23
UCECchr8140547549Missense_MutationnovelT556M0.26
UCECchr8140557215SilentnovelS300S0.2
UCECchr8140559506Missense_MutationnovelA227T0.42
UCECchr8140541234Missense_MutationnovelK655T0.33
UCECchr8140544246Frame_Shift_Delrs779015608A603Pfs*920.47
UCECchr8140532569Missense_MutationNAR773H0.37PAZ
UCECchr8140557206SilentNAT303T0.25
UCECchr8140549237Missense_MutationNAP489S0.28
UCECchr8140555944Silentrs747025316D407D0.38
UCSchr8140535501SilentNAF746F0.06

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
DLBCAMP0.250.018626
KIRCAMP0.12120.15559
SARCAMP0.26070.18425
SKCMAMP0.4552.8957e-05
TGCTAMP0.55330.13696
UVMAMP0.73758.8879e-13

Survival Analysis
CancerP-value Q-value
THYM0.014

Kaplan-Meier Survival Analysis

SARC0.0004

Kaplan-Meier Survival Analysis

MESO0.00037

Kaplan-Meier Survival Analysis

ACC0.00011

Kaplan-Meier Survival Analysis

BRCA0.025

Kaplan-Meier Survival Analysis

KIRP0.00039

Kaplan-Meier Survival Analysis

CESC0.0065

Kaplan-Meier Survival Analysis

KICH0.016

Kaplan-Meier Survival Analysis

UCEC0.00012

Kaplan-Meier Survival Analysis

LIHC0.0021

Kaplan-Meier Survival Analysis

LGG0.00021

Kaplan-Meier Survival Analysis

CHOL0.0091

Kaplan-Meier Survival Analysis

UVM0.016

Kaplan-Meier Survival Analysis

Drugs

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Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBDs
  • RBPome
  • Literatures
  • Expression
  • Transcripts
  • Gene Model
  • Phenotypes
  • GWAS
  • PPI
  • Paralogs
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000123908 (Gene tree)
Gene ID
27161
Gene Symbol
AGO2
Alias
hAGO2|Q10|LINC00980|EIF2C2|CASC7
Full Name
argonaute RISC catalytic component 2
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Minus strand
Length
122,171 bases
Position
chr8:140,520,156-140,642,326
Accession
3263
RBP type
canonical RBP
Summary
This gene encodes a member of the Argonaute family of proteins which play a role in RNA interference. The encoded protein is highly basic, and contains a PAZ domain and a PIWI domain. It may interact with dicer1 and play a role in short-interfering-RNA-mediated gene silencing. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]
RNA binding domains(RBDs)
Protein IDDomain Pfam IDE-value Domain number Total number
ENSP00000430176PAZPF02170.223.3e-2611
ENSP00000220592PAZPF02170.223.6e-2611
ENSP00000220592PiwiPF02171.178.8e-11511
ENSP00000430176PiwiPF02171.178.6e-9312
ENSP00000430176PiwiPF02171.178.6e-9322
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
22681889The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts4SURIC & HEK2932012 MayBaltz AGDOI: 10.1016/j.molcel.2012.05.021
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & HEK2932019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & HEK2932018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
29431736Capturing the interactome of newly transcribed RNARIC & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
22658674Insights into RNA biology from an atlas of mammalian mRNA-binding proteinsRIC & Hela2012 May 31Castello ADOI: 10.1016/j.cell.2012.04.031
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & Hela2018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & MCF72018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & U2OS2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30352994Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome captureRIC & Jurkat2018 Oct 23Perez-Perri JIDOI:10.1038/s41467-018-06557-8

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
19625255Binding and cleavage specificities of human Argonaute2.J Biol Chem2009 Sep 18Lima WFdoi: 10.1074/jbc.M109.010835
23897118MicroRNA-146a and RBM4 form a negative feed-forward loop that disrupts cytokine mRNA translation following TLR4 responses in human THP-1 monocytes.Immunol Cell Biol2013 SepBrudecki Ldoi: 10.1038/icb.2013.37
16424907The role of PACT in the RNA silencing pathway.EMBO J2006 Feb 8Lee Y-
19801630RNA-binding motif protein 4 translocates to cytoplasmic granules and suppresses translation via argonaute2 during muscle cell differentiation.J Biol Chem2009 Dec 11Lin JCdoi: 10.1074/jbc.M109.032946
21262214The Bin3 RNA methyltransferase is required for repression of caudal translation in the Drosophila embryo.Dev Biol2011 Apr 1Singh Ndoi: 10.1016/j.ydbio.2011.01.017
23531496Multiple sensors ensure guide strand selection in human RNAi pathways.RNA2013 MayNoland CLdoi: 10.1261/rna.037424.112
25998849Processing Body Formation Limits Proinflammatory Cytokine Synthesis in Endotoxin-Tolerant Monocytes and Murine Septic Macrophages.J Innate Immun2015McClure Cdoi: 10.1159/000381915
31289130Sequestration of microRNA-mediated target repression by the Ago2-associated RNA binding protein FAM120A.RNA2019 Jul 9Kelly TJdoi: 10.1261/rna.071621.119
29017520The nuclear receptor ERβ engages AGO2 in regulation of gene transcription, RNA splicing and RISC loading.Genome Biol2017 Oct 6Tarallo Rdoi: 10.1186/s13059-017-1321-0.
29694981CircRNA-Cdr1as Exerts Anti-Oncogenic Functions in Bladder Cancer by Sponging MicroRNA-135a.Cell Physiol Biochem2018Li Pdoi: 10.1159/000489208
19820710Structural insights into RNA processing by the human RISC-loading complex.Nat Struct Mol Biol2009 NovWang HWdoi: 10.1038/nsmb.1673
19422693Characterization of the TRBP domain required for dicer interaction and function in RNA interference.BMC Mol Biol2009 May 7Daniels SMdoi: 10.1186/1471-2199-10-38.
17360756Small interfering RNAs against the TAR RNA binding protein, TRBP, a Dicer cofactor, inhibit human immunodeficiency virus type 1 long terminal repeat expression and viral production.J Virol2007 MayChristensen HS-
21951848MicroRNA-binding is required for recruitment of human Argonaute 2 to stress granules and P-bodies.Biochem Biophys Res Commun2011 Oct 14Pare JMdoi: 10.1016/j.bbrc.2011.09.068
24663241Identifying mRNA sequence elements for target recognition by human Argonaute proteins.Genome Res2014 MayLi Jdoi: 10.1101/gr.162230.113
23824327Remodeling of Ago2-mRNA interactions upon cellular stress reflects miRNA complementarity and correlates with altered translation rates.Genes Dev2013 Jul 15Karginov FVdoi: 10.1101/gad.215939.113
26311052Long non-coding RNA MALAT1 modulates radiosensitivity of HR-HPV+ cervical cancer via sponging miR-145.Tumour Biol2016 FebLu Hdoi: 10.1007/s13277-015-3946-5
27582469Parent-of-origin effects of A1CF and AGO2 on testicular germ-cell tumors, testicular abnormalities, and fertilization bias.Proc Natl Acad Sci U S A2016 Sep 13Carouge Ddoi: 10.1073/pnas.1604773113
27343009Clinical relevance of circulating cell-free microRNAs in ovarian cancer.Mol Cancer2016 Jun 24Nakamura Kdoi: 10.1186/s12943-016-0536-0.
16271387Human RISC couples microRNA biogenesis and posttranscriptional gene silencing.Cell2005 Nov 18Gregory RI-
19808937Expanded RNA-binding activities of mammalian Argonaute 2.Nucleic Acids Res2009 DecTan GSdoi: 10.1093/nar/gkp812.
22961479Expression of microRNA machinery proteins in different types of chronic rhinosinusitis.Laryngoscope2012 DecZhang YNdoi: 10.1002/lary.23517
22841487LincRNA-p21 suppresses target mRNA translation.Mol Cell2012 Aug 24Yoon JHdoi: 10.1016/j.molcel.2012.06.027
22314808Horizontal transfer of microRNAs: molecular mechanisms and clinical applications.Protein Cell2012 JanChen Xdoi: 10.1007/s13238-012-2003-z
23303783Combinatorial mRNA binding by AUF1 and Argonaute 2 controls decay of selected target mRNAs.Nucleic Acids Res2013 Feb 1Wu Xdoi: 10.1093/nar/gks1453
22059153Extracellular/circulating microRNAs and their potential role in cardiovascular disease.Am J Cardiovasc Dis2011 Jul 30Zhu H-
22025453Expression levels of the microRNA maturing microprocessor complex component DGCR8 and the RNA-induced silencing complex (RISC) components argonaute-1, argonaute-2, PACT, TARBP1, and TARBP2 in epithelial skin cancer.Mol Carcinog2012 NovSand Mdoi: 10.1002/mc.20861
22026461Small molecule inhibition of RISC loading.ACS Chem Biol2012 Feb 17Tan GSdoi: 10.1021/cb200253h
21562054MicroRNA-146a regulates both transcription silencing and translation disruption of TNF-α during TLR4-induced gene reprogramming.J Leukoc Biol2011 SepEl Gazzar Mdoi: 10.1189/jlb.0211074
21245036Loqs-PD and R2D2 define independent pathways for RISC generation in Drosophila.Nucleic Acids Res2011 MayHartig JVdoi: 10.1093/nar/gkq1324
21256150Identification and functional characterization of Dicer2 and five single VWC domain proteins of Litopenaeus vannamei.Dev Comp Immunol2011 JunChen YHdoi: 10.1016/j.dci.2011.01.010
25645911Anti-tumoral effects of miR-3189-3p in glioblastoma.J Biol Chem2015 Mar 27Jeansonne Ddoi: 10.1074/jbc.M114.633081
24837588Argonaute-2 promotes miR-18a entry in human brain endothelial cells.J Am Heart Assoc2014 May 16Ferreira Rdoi: 10.1161/JAHA.114.000968.
24662483Ago2 facilitates Rad51 recruitment and DNA double-strand break repair by homologous recombination.Cell Res2014 MayGao Mdoi: 10.1038/cr.2014.36
24563462Trans-activation response (TAR) RNA-binding protein 2 is a novel modulator of transient receptor potential canonical 4 (TRPC4) protein.J Biol Chem2014 Apr 4Zimmermann Jdoi: 10.1074/jbc.M114.557066
24391810siRNA machinery in whitefly (Bemisia tabaci).PLoS One2013 Dec 31Upadhyay SKdoi: 10.1371/journal.pone.0083692
24141778Ribosomal proteins L5 and L11 co-operatively inactivate c-Myc via RNA-induced silencing complex.Oncogene2014 Oct 9Liao JMdoi: 10.1038/onc.2013.430
23902134MicroRNA-specific argonaute 2 protein inhibitors.ACS Chem Biol2013 Oct 18Schmidt MFdoi: 10.1021/cb400246k
23511973The rough endoplasmatic reticulum is a central nucleation site of siRNA-mediated RNA silencing.EMBO J2013 Apr 17Stalder Ldoi: 10.1038/emboj.2013.52
26935291Role of Alix in miRNA packaging during extracellular vesicle biogenesis.Int J Mol Med2016 AprIavello Adoi: 10.3892/ijmm.2016.2488
25918241Argonaute 2 Binds Directly to tRNA Genes and Promotes Gene Repression in cis.Mol Cell Biol2015 JulWoolnough JL-
27924489Kinetic Analysis of Target RNA Binding and Slicing by Human Argonaute 2 Protein.Methods Mol Biol2017Willkomm S-
27478153The miRNA biogenesis factors, p72/DDX17 and KHSRP regulate the protein level of Ago2 in human cells.Biochim Biophys Acta2016 OctConnerty Pdoi: 10.1016/j.bbagrm.2016.07.013
27387838Structure-Guided Control of siRNA Off-Target Effects.J Am Chem Soc2016 Jul 20Suter SRdoi: 10.1021/jacs.6b06137
26832224Transcriptional silencing of long noncoding RNA GNG12-AS1 uncouples its transcriptional and product-related functions.Nat Commun2016 Feb 2Stojic Ldoi: 10.1038/ncomms10406.
26451954HuR and Ago2 Bind the Internal Ribosome Entry Site of Enterovirus 71 and Promote Virus Translation and Replication.PLoS One2015 Oct 9Lin JYdoi: 10.1371/journal.pone.0140291
26379499Oligodendroglial Argonaute protein Ago2 associates with molecules of the Mbp mRNA localization machinery and is a downstream target of Fyn kinase.Front Cell Neurosci2015 Aug 25Muller Cdoi: 10.3389/fncel.2015.00328
26002194Life-long norepinephrine transporter (NET) knock-out leads to the increase in the NET mRNA in brain regions rich in norepinephrine terminals.Eur Neuropsychopharmacol2015 AugSolich Jdoi: 10.1016/j.euroneuro.2015.04.019
28634830The microRNA effector RNA-induced silencing complex in hidradenitis suppurativa: a significant dysregulation within active inflammatory lesions.Arch Dermatol Res2017 SepHessam Sdoi: 10.1007/s00403-017-1752-1
29396181Argonaute 2 Is Required for Extra-embryonic Endoderm Differentiation of Mouse Embryonic Stem Cells.Stem Cell Reports2018 Feb 13Ngondo RPdoi: 10.1016/j.stemcr.2017.12.023
29499134FUS Regulates Activity of MicroRNA-Mediated Gene Silencing.Mol Cell2018 Mar 1Zhang Tdoi: 10.1016/j.molcel.2018.02.001.
29704631CircRNF13 regulates the invasion and metastasis in lung adenocarcinoma by targeting miR-93-5p.Gene2018 Sep 10Wang Ldoi: 10.1016/j.gene.2018.04.069
30348590Control of hepatic gluconeogenesis by Argonaute2.Mol Metab2018 DecYan Xdoi: 10.1016/j.molmet.2018.10.003
30567739Serine 195 phosphorylation in the RNA-binding protein Rbm38 increases p63 expression by modulating Rbm38's interaction with the Ago2-miR203 complex.J Biol Chem2019 Feb 15Zhang Ydoi: 10.1074/jbc.RA118.005779
31324449High-Throughput Analysis Reveals Rules for Target RNA Binding and Cleavage by AGO2.Mol Cell2019 Jul 16Becker WRdoi: 10.1016/j.molcel.2019.06.012
23405269MicroRNA-122 dependent binding of Ago2 protein to hepatitis C virus RNA is associated with enhanced RNA stability and translation stimulation.PLoS One2013Conrad KDdoi: 10.1371/journal.pone.0056272
23999091Promoter RNA links transcriptional regulation of inflammatory pathway genes.Nucleic Acids Res2013 DecMatsui Mdoi: 10.1093/nar/gkt777
27472220Correction: microRNA-122 Dependent Binding of Ago2 Protein to Hepatitis C Virus RNA Is Associated with Enhanced RNA Stability and Translation Stimulation.PLoS One2016 Jul 29Conrad KDdoi: 10.1371/journal.pone.0160132
24719423hnRNP L and NF90 interact with hepatitis C virus 5'-terminal untranslated RNA and promote efficient replication.J Virol2014 JulLi Ydoi: 10.1128/JVI.00225-14
26507454miR-346 and miR-138 competitively regulate hTERT in GRSF1- and AGO2-dependent manners, respectively.Sci Rep2015 Oct 28Song Gdoi: 10.1038/srep15793.
26084291miRNA-337-3p suppresses neuroblastoma progression by repressing the transcription of matrix metalloproteinase 14.Oncotarget2015 Sep 8Xiang X-
16287716Slicer function of Drosophila Argonautes and its involvement in RISC formation.Genes Dev2005 Dec 1Miyoshi K-
16301602Small interfering RNAs containing full 2'-O-methylribonucleotide-modified sense strands display Argonaute2/eIF2C2-dependent activity.RNA2006 JanKraynack BA-
23085987Wig1 prevents cellular senescence by regulating p21 mRNA decay through control of RISC recruitment.EMBO J2012 Nov 14Kim BCdoi: 10.1038/emboj.2012.286
18591665Coexpression of Argonaute-2 enhances RNA interference toward perfect match binding sites.Proc Natl Acad Sci U S A2008 Jul 8Diederichs Sdoi: 10.1073/pnas.0800803105
18267968Functional dissection of siRNA sequence by systematic DNA substitution: modified siRNA with a DNA seed arm is a powerful tool for mammalian gene silencing with significantly reduced off-target effect.Nucleic Acids Res2008 AprUi-Tei Kdoi: 10.1093/nar/gkn042
22363633Small RNAs targeting transcription start site induce heparanase silencing through interference with transcription initiation in human cancer cells.PLoS One2012Jiang Gdoi: 10.1371/journal.pone.0031379
22184245Murine cytomegalovirus encodes a miR-27 inhibitor disguised as a target.Proc Natl Acad Sci U S A2012 Jan 3Libri Vdoi: 10.1073/pnas.1114204109
21945804miRNA Expression profile after status epilepticus and hippocampal neuroprotection by targeting miR-132.Am J Pathol2011 NovJimenez-Mateos EMdoi: 10.1016/j.ajpath.2011.07.036
21122261Autoantibodies to a miRNA-binding protein Argonaute2 (Su antigen) in patients with hepatitis C virus infection.Clin Exp Rheumatol2010 Nov-DecVazquez-Del Mercado M-
20976148The microRNA and messengerRNA profile of the RNA-induced silencing complex in human primary astrocyte and astrocytoma cells.PLoS One2010 Oct 18Moser JJdoi: 10.1371/journal.pone.0013445.
25635512Structure-based design of novel chemical modification of the 3'-overhang for optimization of short interfering RNA performance.Biochemistry2015 Feb 10Xu Ldoi: 10.1021/bi500602z
24389009Transcriptome-wide discovery of microRNA binding sites in human brain.Neuron2014 Jan 22Boudreau RLdoi: 10.1016/j.neuron.2013.10.062
24152142Short interfering RNA guide strand modifiers from computational screening.J Am Chem Soc2013 Nov 13Onizuka Kdoi: 10.1021/ja4079754
24101500Minimal mechanistic model of siRNA-dependent target RNA slicing by recombinant human Argonaute 2 protein.Proc Natl Acad Sci U S A2013 Oct 29Deerberg Adoi: 10.1073/pnas.1217838110
24009507Functional specialization of the small interfering RNA pathway in response to virus infection.PLoS Pathog2013Marques JTdoi: 10.1371/journal.ppat.1003579
23616647Modulation of GB virus B RNA abundance by microRNA-122: dependence on and escape from microRNA-122 restriction.J Virol2013 JulSagan SMdoi: 10.1128/JVI.00378-13
23535175Role of Rck-Pat1b binding in assembly of processing-bodies.RNA Biol2013 AprOzgur Sdoi: 10.4161/rna.24086
23471483Nucleolin mediates microRNA-directed CSF-1 mRNA deadenylation but increases translation of CSF-1 mRNA.Mol Cell Proteomics2013 JunWoo HHdoi: 10.1074/mcp.M112.025288
26188511SUMOylation of Argonaute-2 regulates RNA interference activity.Biochem Biophys Res Commun2015 Sep 4Josa-Prado Fdoi: 10.1016/j.bbrc.2015.07.073
26712743Novel Insights into Guide RNA 5'-Nucleoside/Tide Binding by Human Argonaute 2.Int J Mol Sci2015 Dec 24Kalia Mdoi: 10.3390/ijms17010022.
27288410Human Argonaute 2 Is Tethered to Ribosomal RNA through MicroRNA Interactions.J Biol Chem2016 Aug 19Atwood BLdoi: 10.1074/jbc.M116.725051
27924485Small Molecules Targeting the miRNA-Binding Domain of Argonaute 2: From Computer-Aided Molecular Design to RNA Immunoprecipitation.Methods Mol Biol2017Bellissimo T-
27418678Elucidation of transcriptome-wide microRNA binding sites in human cardiac tissues by Ago2 HITS-CLIP.Nucleic Acids Res2016 Sep 6Spengler RMdoi: 10.1093/nar/gkw640
28008821Cooperative enhancement of translation by two adjacent microRNA-122/Argonaute 2 complexes binding to the 5' untranslated region of hepatitis C virus RNA.J Gen Virol2017 FebNieder-Rohrmann Adoi: 10.1099/jgv.0.000697
26784517Recombinant hTRBP and hPACT Modulate hAgo2-Catalyzed siRNA-Mediated Target RNA Cleavage In Vitro.PLoS One2016 Jan 19Willkomm Sdoi: 10.1371/journal.pone.0146814
26355083Requirement for Host RNA-Silencing Components and the Virus-Silencing Suppressor when Second-Site Mutations Compensate for Structural Defects in the 3' Untranslated Region.J Virol2015 NovChattopadhyay Mdoi: 10.1128/JVI.01566-15
26359634Water-mediated recognition of t1-adenosine anchors Argonaute2 to microRNA targets.Elife2015 Sep 11Schirle NTdoi: 10.7554/eLife.07646.
26253535AUF1 promotes let-7b loading on Argonaute 2.Genes Dev2015 Aug 1Yoon JHdoi: 10.1101/gad.263749.115.
28369725RNA Polymerase I Inhibition with CX-5461 as a Novel Therapeutic Strategy to Target MYC in Multiple Myeloma.Br J Haematol2017 AprLee HCdoi: 10.1111/bjh.14525.
29511611miR-322-5p targets IGF-1 and is suppressed in the heart of rats with pulmonary hypertension.FEBS Open Bio2018 Jan 24Connolly Mdoi: 10.1002/2211-5463.12369
30997501TNRC6 proteins modulate hepatitis C virus replication by spatially regulating the binding of miR-122/Ago2 complexes to viral RNA.Nucleic Acids Res2019 Jul 9Li Ydoi: 10.1093/nar/gkz278.
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000523609AGO2-2093050-ENSP0000043016473 (aa)-E5RGG9
ENST00000517293AGO2-202422--- (aa)--
ENST00000518019AGO2-203421--- (aa)--
ENST00000520412AGO2-206614--- (aa)--
ENST00000519347AGO2-204309--- (aa)--
ENST00000519980AGO2-2053141-ENSP00000430176825 (aa)-Q9UKV8
ENST00000524328AGO2-210316-ENSP0000043105636 (aa)-E5RJY2
ENST00000520628AGO2-207350--- (aa)--
ENST00000521325AGO2-208683--- (aa)--
ENST00000220592AGO2-20114581XM_011516965ENSP00000220592859 (aa)XP_011515267Q9UKV8
Gene Model
Click here to download ENSG00000123908's gene model file
Phenotypes
ensgIDTraitpValuePubmed ID
ENSG00000123908Glucose8E-623400010
ENSG00000123908Hydrochlorothiazide8E-623400010
GWAS
ensgIDSNPChromosomePositionSNP-risk TraitPubmedID95% CIOr or BEAT EFO ID
ENSG00000123908rs29447558140564095AThiazide-induced adverse metabolic effects in hypertensive patients23400010[5.31-13.59] mg/dL decrease9.45EFO_0005202|EFO_0004465
ENSG00000123908rs29774648140535094TCognitive performance30038396[0.014-0.028] unit increase0.0209EFO_0008354
ENSG00000123908rs29774648140535094TEducational attainment (MTAG)30038396[0.0078-0.0144] unit increase0.0111EFO_0004784
ENSG00000123908rs29447728140538320CSelf-reported math ability (MTAG)30038396[0.0095-0.0185] unit decrease0.014EFO_0004875
ENSG00000123908rs29774648140535094THighest math class taken (MTAG)30038396[0.0099-0.0181] unit increase0.014EFO_0004875
ENSG00000123908rs19621048140625230TExperiencing mood swings29500382z score decrease6.42EFO_0008475
ENSG00000123908rs29774648140535094TCognitive performance (MTAG)30038396[0.015-0.026] unit increase0.0208EFO_0008354
ENSG00000123908rs29774648140535094TEducational attainment (years of education)30038396[0.0067-0.0137] unit increase0.0102EFO_0004784
ENSG00000123908rs117830238140629163?Hypothyroidism30595370EFO_0004705
ENSG00000123908rs65781258140618442?Mean corpuscular hemoglobin30595370EFO_0004527
ENSG00000123908rs19621048140625230?Neuroticism30595370EFO_0007660
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000123908's network

* RBP PPI network refers to all genes directly bind to RBP
Paralogs
Ensembl IDGene SymbolCoverageIdentiy ParalogGene SymbolCoverageIdentiy
ENSG00000123908AGO210083.333ENSG00000092847AGO110084.802
ENSG00000123908AGO29979.745ENSG00000126070AGO310085.623
ENSG00000123908AGO29978.372ENSG00000134698AGO49979.034
Orthologs
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000123908AGO29893.445ENSAPOG00000017586ago29693.445Acanthochromis_polyacanthus
ENSG00000123908AGO2100100.000ENSAMEG00000005019AGO210099.301Ailuropoda_melanoleuca
ENSG00000123908AGO28193.669ENSACIG00000001179ago29693.669Amphilophus_citrinellus
ENSG00000123908AGO29893.921ENSAOCG00000015307ago29693.921Amphiprion_ocellaris
ENSG00000123908AGO29893.921ENSAPEG00000018425ago29693.921Amphiprion_percula
ENSG00000123908AGO210090.992ENSATEG00000000529ago29693.921Anabas_testudineus
ENSG00000123908AGO2100100.000ENSAPLG00000010465AGO29998.946Anas_platyrhynchos
ENSG00000123908AGO2100100.000ENSACAG00000000167AGO29998.485Anolis_carolinensis
ENSG00000123908AGO2100100.000ENSANAG00000027399AGO210099.767Aotus_nancymaae
ENSG00000123908AGO28094.606ENSACLG00000024684ago29894.606Astatotilapia_calliptera
ENSG00000123908AGO29992.941ENSAMXG00000014587ago29893.564Astyanax_mexicanus
ENSG00000123908AGO2100100.000ENSBTAG00000001579AGO210099.884Bos_taurus
ENSG00000123908AGO29866.783WBGene00000106alg-29666.901Caenorhabditis_elegans
ENSG00000123908AGO29867.431WBGene00000105alg-18767.431Caenorhabditis_elegans
ENSG00000123908AGO2100100.000ENSCJAG00000004132AGO210099.884Callithrix_jacchus
ENSG00000123908AGO2100100.000ENSCAFG00000001196AGO210099.877Canis_familiaris
ENSG00000123908AGO2100100.000ENSCAFG00020014198AGO29999.765Canis_lupus_dingo
ENSG00000123908AGO2100100.000ENSCHIG00000010156AGO210099.884Capra_hircus
ENSG00000123908AGO2100100.000ENSTSYG00000007281AGO210099.756Carlito_syrichta
ENSG00000123908AGO2100100.000ENSCAPG00000013707AGO29884.460Cavia_aperea
ENSG00000123908AGO2100100.000ENSCPOG00000010428AGO29999.883Cavia_porcellus
ENSG00000123908AGO2100100.000ENSCCAG00000035031AGO210099.883Cebus_capucinus
ENSG00000123908AGO29996.400ENSCATG00000038820AGO210096.400Cercocebus_atys
ENSG00000123908AGO2100100.000ENSCLAG00000001381AGO210099.418Chinchilla_lanigera
ENSG00000123908AGO2100100.000ENSCSAG00000009574AGO29599.766Chlorocebus_sabaeus
ENSG00000123908AGO267100.000ENSCHOG00000008938-8484.633Choloepus_hoffmanni
ENSG00000123908AGO2100100.000ENSCPBG00000019183AGO210097.821Chrysemys_picta_bellii
ENSG00000123908AGO29772.353ENSCING00000007310-9872.353Ciona_intestinalis
ENSG00000123908AGO29773.113ENSCSAVG00000005282-9979.104Ciona_savignyi
ENSG00000123908AGO29996.014ENSCANG00000030899AGO29996.014Colobus_angolensis_palliatus
ENSG00000123908AGO2100100.000ENSCGRG00001013557Ago210099.070Cricetulus_griseus_chok1gshd
ENSG00000123908AGO2100100.000ENSCGRG00000002120Ago210099.178Cricetulus_griseus_crigri
ENSG00000123908AGO29893.445ENSCSEG00000012273ago29693.445Cynoglossus_semilaevis
ENSG00000123908AGO29892.968ENSCVAG00000008763ago210092.539Cyprinodon_variegatus
ENSG00000123908AGO29992.281ENSDARG00000061268ago29693.222Danio_rerio
ENSG00000123908AGO29297.595ENSDNOG00000033433AGO210097.595Dasypus_novemcinctus
ENSG00000123908AGO2100100.000ENSDORG00000011242Ago29999.296Dipodomys_ordii
ENSG00000123908AGO29973.533FBgn0262739AGO19074.443Drosophila_melanogaster
ENSG00000123908AGO28086.192ENSEBUG00000006807-10086.192Eptatretus_burgeri
ENSG00000123908AGO29486.757ENSEBUG00000011986-10086.757Eptatretus_burgeri
ENSG00000123908AGO28188.905ENSEBUG00000014654ago210088.905Eptatretus_burgeri
ENSG00000123908AGO29357.263ENSEBUG00000014681ago29957.263Eptatretus_burgeri
ENSG00000123908AGO28086.172ENSEBUG00000008202-9986.172Eptatretus_burgeri
ENSG00000123908AGO2100100.000ENSEASG00005021922AGO2100100.000Equus_asinus_asinus
ENSG00000123908AGO2100100.000ENSECAG00000006078AGO210099.651Equus_caballus
ENSG00000123908AGO2100100.000ENSEEUG00000008564-7498.951Erinaceus_europaeus
ENSG00000123908AGO29892.857ENSELUG00000019378ago29692.857Esox_lucius
ENSG00000123908AGO2100100.000ENSFCAG00000002782AGO210099.651Felis_catus
ENSG00000123908AGO2100100.000ENSFALG00000002838AGO29998.945Ficedula_albicollis
ENSG00000123908AGO2100100.000ENSFDAG00000004759AGO210099.883Fukomys_damarensis
ENSG00000123908AGO29493.432ENSFHEG00000016080ago29693.432Fundulus_heteroclitus
ENSG00000123908AGO29892.729ENSGMOG00000013651ago29892.518Gadus_morhua
ENSG00000123908AGO2100100.000ENSGALG00000040957AGO210098.264Gallus_gallus
ENSG00000123908AGO210091.600ENSGAFG00000018026ago29793.683Gambusia_affinis
ENSG00000123908AGO210091.686ENSGACG00000006796ago29893.564Gasterosteus_aculeatus
ENSG00000123908AGO2100100.000ENSGAGG00000003914AGO210099.489Gopherus_agassizii
ENSG00000123908AGO2100100.000ENSGGOG00000011412AGO210099.883Gorilla_gorilla
ENSG00000123908AGO210092.782ENSHBUG00000018515ago29894.606Haplochromis_burtoni
ENSG00000123908AGO2100100.000ENSHGLG00000005548AGO29999.883Heterocephalus_glaber_female
ENSG00000123908AGO2100100.000ENSHGLG00100000694-9889.074Heterocephalus_glaber_male
ENSG00000123908AGO2100100.000ENSHGLG00100015994-9999.648Heterocephalus_glaber_male
ENSG00000123908AGO29893.921ENSHCOG00000006200ago29893.921Hippocampus_comes
ENSG00000123908AGO210091.967ENSIPUG00000001018ago29893.103Ictalurus_punctatus
ENSG00000123908AGO2100100.000ENSSTOG00000008113AGO210099.648Ictidomys_tridecemlineatus
ENSG00000123908AGO2100100.000ENSJJAG00000018712Ago210098.843Jaculus_jaculus
ENSG00000123908AGO210092.200ENSKMAG00000019999ago29893.445Kryptolebias_marmoratus
ENSG00000123908AGO29893.445ENSLBEG00000005112ago29693.445Labrus_bergylta
ENSG00000123908AGO210091.667ENSLACG00000001277-9888.507Latimeria_chalumnae
ENSG00000123908AGO29893.325ENSLOCG00000007766ago29793.325Lepisosteus_oculatus
ENSG00000123908AGO2100100.000ENSLAFG00000012905AGO29999.648Loxodonta_africana
ENSG00000123908AGO2100100.000ENSMFAG00000015384AGO210099.883Macaca_fascicularis
ENSG00000123908AGO2100100.000ENSMMUG00000008045AGO29999.650Macaca_mulatta
ENSG00000123908AGO2100100.000ENSMNEG00000019904AGO29999.766Macaca_nemestrina
ENSG00000123908AGO2100100.000ENSMLEG00000038874AGO210099.878Mandrillus_leucophaeus
ENSG00000123908AGO210090.992ENSMAMG00000008662ago29991.548Mastacembelus_armatus
ENSG00000123908AGO29893.921ENSMZEG00005008998ago29894.606Maylandia_zebra
ENSG00000123908AGO2100100.000ENSMGAG00000012942AGO29998.944Meleagris_gallopavo
ENSG00000123908AGO2100100.000ENSMAUG00000007785Ago29991.080Mesocricetus_auratus
ENSG00000123908AGO2100100.000ENSMICG00000004427AGO210099.651Microcebus_murinus
ENSG00000123908AGO2100100.000ENSMOCG00000000300Ago210099.531Microtus_ochrogaster
ENSG00000123908AGO29790.822ENSMMOG00000020165ago210090.822Mola_mola
ENSG00000123908AGO2100100.000ENSMODG00000000748AGO210098.724Monodelphis_domestica
ENSG00000123908AGO210092.549ENSMALG00000020610ago210092.549Monopterus_albus
ENSG00000123908AGO2100100.000MGP_CAROLIEiJ_G0019861Ago210099.186Mus_caroli
ENSG00000123908AGO2100100.000ENSMUSG00000036698Ago210099.186Mus_musculus
ENSG00000123908AGO2100100.000MGP_PahariEiJ_G0019867Ago210098.953Mus_pahari
ENSG00000123908AGO2100100.000MGP_SPRETEiJ_G0020759Ago210099.177Mus_spretus
ENSG00000123908AGO2100100.000ENSMPUG00000001930AGO29999.882Mustela_putorius_furo
ENSG00000123908AGO26687.456ENSMLUG00000004552-10087.346Myotis_lucifugus
ENSG00000123908AGO2100100.000ENSNGAG00000014556Ago29999.412Nannospalax_galili
ENSG00000123908AGO29893.921ENSNBRG00000006100ago29693.921Neolamprologus_brichardi
ENSG00000123908AGO2100100.000ENSNLEG00000001461AGO29894.626Nomascus_leucogenys
ENSG00000123908AGO28790.476ENSMEUG00000001395AGO28698.039Notamacropus_eugenii
ENSG00000123908AGO29987.192ENSOPRG00000008795-10087.192Ochotona_princeps
ENSG00000123908AGO2100100.000ENSODEG00000014145AGO210099.883Octodon_degus
ENSG00000123908AGO210091.379ENSONIG00000010747ago29693.921Oreochromis_niloticus
ENSG00000123908AGO2100100.000ENSOANG00000007125AGO29999.180Ornithorhynchus_anatinus
ENSG00000123908AGO2100100.000ENSOCUG00000006066AGO210097.773Oryctolagus_cuniculus
ENSG00000123908AGO210091.967ENSORLG00000004615ago29893.325Oryzias_latipes
ENSG00000123908AGO210091.967ENSORLG00020003449ago29893.325Oryzias_latipes_hni
ENSG00000123908AGO210091.967ENSORLG00015015319ago29893.325Oryzias_latipes_hsok
ENSG00000123908AGO210092.084ENSOMEG00000017751ago29893.445Oryzias_melastigma
ENSG00000123908AGO2100100.000ENSOGAG00000007933AGO210099.883Otolemur_garnettii
ENSG00000123908AGO2100100.000ENSOARG00000003763AGO210098.246Ovis_aries
ENSG00000123908AGO2100100.000ENSPPAG00000037787AGO2100100.000Pan_paniscus
ENSG00000123908AGO2100100.000ENSPPRG00000002594AGO210099.756Panthera_pardus
ENSG00000123908AGO2100100.000ENSPTIG00000007438AGO29998.474Panthera_tigris_altaica
ENSG00000123908AGO2100100.000ENSPTRG00000020622AGO29999.766Pan_troglodytes
ENSG00000123908AGO2100100.000ENSPANG00000005604AGO210096.857Papio_anubis
ENSG00000123908AGO29892.610ENSPKIG00000001824ago210093.741Paramormyrops_kingsleyae
ENSG00000123908AGO2100100.000ENSPSIG00000004064AGO210096.980Pelodiscus_sinensis
ENSG00000123908AGO2100100.000ENSPEMG00000008137Ago210099.413Peromyscus_maniculatus_bairdii
ENSG00000123908AGO210066.667ENSPMAG00000008265-9962.000Petromyzon_marinus
ENSG00000123908AGO29272.727ENSPMAG00000008422-9479.062Petromyzon_marinus
ENSG00000123908AGO2100100.000ENSPCIG00000026513AGO210098.724Phascolarctos_cinereus
ENSG00000123908AGO210091.484ENSPFOG00000005321ago29793.445Poecilia_formosa
ENSG00000123908AGO210091.484ENSPLAG00000007911ago29793.445Poecilia_latipinna
ENSG00000123908AGO210091.369ENSPMEG00000007977ago29793.325Poecilia_mexicana
ENSG00000123908AGO210090.982ENSPREG00000002072ago29794.430Poecilia_reticulata
ENSG00000123908AGO28984.375ENSPPYG00000018908-10099.745Pongo_abelii
ENSG00000123908AGO2100100.000ENSPCAG00000002880AGO29994.194Procavia_capensis
ENSG00000123908AGO2100100.000ENSPCOG00000023047AGO210099.883Propithecus_coquereli
ENSG00000123908AGO210097.222ENSPVAG00000013238AGO210083.256Pteropus_vampyrus
ENSG00000123908AGO210092.782ENSPNYG00000019928ago29894.606Pundamilia_nyererei
ENSG00000123908AGO29992.649ENSPNAG00000029030ago29693.698Pygocentrus_nattereri
ENSG00000123908AGO2100100.000ENSRNOG00000008533Ago29799.296Rattus_norvegicus
ENSG00000123908AGO2100100.000ENSRBIG00000028225AGO210099.883Rhinopithecus_bieti
ENSG00000123908AGO2100100.000ENSRROG00000003162AGO29999.883Rhinopithecus_roxellana
ENSG00000123908AGO2100100.000ENSSBOG00000018934AGO210099.765Saimiri_boliviensis_boliviensis
ENSG00000123908AGO2100100.000ENSSHAG00000009593AGO210098.724Sarcophilus_harrisii
ENSG00000123908AGO29893.230ENSSFOG00015012817ago29793.230Scleropages_formosus
ENSG00000123908AGO29893.683ENSSMAG00000014089ago29793.683Scophthalmus_maximus
ENSG00000123908AGO29893.921ENSSDUG00000005726ago29693.921Seriola_dumerili
ENSG00000123908AGO29893.921ENSSLDG00000025582ago29993.921Seriola_lalandi_dorsalis
ENSG00000123908AGO28280.909ENSSARG00000007232-10073.092Sorex_araneus
ENSG00000123908AGO210098.721ENSSPUG00000006608AGO210098.721Sphenodon_punctatus
ENSG00000123908AGO29894.041ENSSPAG00000019543ago29694.041Stegastes_partitus
ENSG00000123908AGO2100100.000ENSSSCG00000005935AGO210099.767Sus_scrofa
ENSG00000123908AGO2100100.000ENSTGUG00000012652-9998.944Taeniopygia_guttata
ENSG00000123908AGO29689.601ENSTRUG00000007370ago29894.251Takifugu_rubripes
ENSG00000123908AGO29893.357ENSTNIG00000017760ago29893.683Tetraodon_nigroviridis
ENSG00000123908AGO268100.000ENSTBEG00000003401-84100.000Tupaia_belangeri
ENSG00000123908AGO2100100.000ENSTTRG00000002872AGO29999.647Tursiops_truncatus
ENSG00000123908AGO2100100.000ENSUAMG00000010074AGO210099.647Ursus_americanus
ENSG00000123908AGO2100100.000ENSUMAG00000019572AGO29993.911Ursus_maritimus
ENSG00000123908AGO2100100.000ENSVVUG00000014692AGO210099.877Vulpes_vulpes
ENSG00000123908AGO210095.309ENSXETG00000023755ago210095.309Xenopus_tropicalis
ENSG00000123908AGO29893.026ENSXCOG00000000634ago29693.445Xiphophorus_couchianus
ENSG00000123908AGO29893.026ENSXMAG00000000787ago29793.445Xiphophorus_maculatus
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0000340RNA 7-methylguanosine cap binding17524464.IDAFunction
GO:0000932P-body20616046.22915799.23125361.IDAComponent
GO:0000993RNA polymerase II complex binding25336585.IDAFunction
GO:0001047core promoter binding25336585.IMPFunction
GO:0003723RNA binding22658674.22681889.HDAFunction
GO:0003725double-stranded RNA binding19966796.IDAFunction
GO:0003727single-stranded RNA binding19966796.IDAFunction
GO:0003743translation initiation factor activity10534406.NASFunction
GO:0004521endoribonuclease activity18178619.IDAFunction
GO:0004521endoribonuclease activity-TASFunction
GO:0005515protein binding14749716.15766526.16289642.16424907.16699599.16756390.17400507.17507929.17531811.17891150.17932509.18178619.19167051.19324964.19383768.19716330.19801630.19820710.19838187.19955415.20616046.20671708.21525958.21840310.21858095.21903422.21981923.22366686.22484317.22915799.23085987.23090477.23125361.23361462.23409027.23622242.23636329.23661684.23741051.24043833.24550003.24726324.24862572.24981741.25336585.25446899.25697406.26496610.27157137.28546213.28877994.IPIFunction
GO:0005634nucleus25336585.ICComponent
GO:0005654nucleoplasm-IDAComponent
GO:0005654nucleoplasm-TASComponent
GO:0005737cytoplasm15260970.20014101.IDAComponent
GO:0005829cytosol-TASComponent
GO:0005844polysome17932509.IDAComponent
GO:0005845mRNA cap binding complex17524464.IDAComponent
GO:0005845mRNA cap binding complex23409027.IDAComponent
GO:0006412translation10534406.NASProcess
GO:0006413translational initiation-IEAProcess
GO:0007223Wnt signaling pathway, calcium modulating pathway-TASProcess
GO:0008022protein C-terminus binding19820710.IPIFunction
GO:0009791post-embryonic development-IEAProcess
GO:0010501RNA secondary structure unwinding19966796.IDAProcess
GO:0010501RNA secondary structure unwinding22795694.IMPProcess
GO:0010586miRNA metabolic process-TASProcess
GO:0010628positive regulation of gene expression-TASProcess
GO:0010629negative regulation of gene expression-TASProcess
GO:0016020membrane19946888.HDAComponent
GO:0016442RISC complex19701182.ICComponent
GO:0016442RISC complex15260970.19966796.20616046.IDAComponent
GO:0030054cell junction-IDAComponent
GO:0030422production of siRNA involved in RNA interference-TASProcess
GO:0030425dendrite-IEAComponent
GO:0031047gene silencing by RNA-ISSProcess
GO:0031054pre-miRNA processing16424907.17671087.18178619.19966796.IDAProcess
GO:0035068micro-ribonucleoprotein complex17531811.17671087.17932509.IDAComponent
GO:0035087siRNA loading onto RISC involved in RNA interference19701182.ICProcess
GO:0035087siRNA loading onto RISC involved in RNA interference19966796.IDAProcess
GO:0035194posttranscriptional gene silencing by RNA-TASProcess
GO:0035196production of miRNAs involved in gene silencing by miRNA19966796.23661684.IDAProcess
GO:0035197siRNA binding17495927.IDAFunction
GO:0035197siRNA binding15973356.19701182.IDAFunction
GO:0035198miRNA binding15260970.19966796.IDAFunction
GO:0035198miRNA binding19820710.TASFunction
GO:0035278miRNA mediated inhibition of translation17671087.19801630.IDAProcess
GO:0035278miRNA mediated inhibition of translation18771919.IMPProcess
GO:0035279mRNA cleavage involved in gene silencing by miRNA15260970.17524464.IDAProcess
GO:0035279mRNA cleavage involved in gene silencing by miRNA18771919.IMPProcess
GO:0035280miRNA loading onto RISC involved in gene silencing by miRNA18178619.19966796.IDAProcess
GO:0042985negative regulation of amyloid precursor protein biosynthetic process-ISSProcess
GO:0045766positive regulation of angiogenesis27208409.IDAProcess
GO:0045944positive regulation of transcription by RNA polymerase II25336585.IMPProcess
GO:0045947negative regulation of translational initiation17524464.19801630.IDAProcess
GO:0046872metal ion binding-IEAFunction
GO:0060213positive regulation of nuclear-transcribed mRNA poly(A) tail shortening-ISSProcess
GO:0060964regulation of gene silencing by miRNA-TASProcess
GO:0070062extracellular exosome28159509.IDAComponent
GO:0070551endoribonuclease activity, cleaving siRNA-paired mRNA15260970.17524464.IDAFunction
GO:0070578RISC-loading complex15973356.17531811.18178619.19820710.19966796.23661684.IDAComponent
GO:0090502RNA phosphodiester bond hydrolysis, endonucleolytic-IEAProcess
GO:0090624endoribonuclease activity, cleaving miRNA-paired mRNA15260970.IDAFunction
GO:0090624endoribonuclease activity, cleaving miRNA-paired mRNA22795694.IMPFunction
GO:0090625mRNA cleavage involved in gene silencing by siRNA15260970.IDAProcess
GO:0090625mRNA cleavage involved in gene silencing by siRNA22795694.IMPProcess
GO:0098808mRNA cap binding23409027.IPIFunction
GO:1900153positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay-ISSProcess
GO:1901165positive regulation of trophoblast cell migration27208409.IMPProcess
GO:1905618positive regulation of miRNA mediated inhibition of translation23409027.IDAProcess
GO:1990904ribonucleoprotein complex17932509.IDAComponent
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