EuRBPDB

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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
17127713Overexpression of iron regulatory protein 1 suppresses growth of tumor xenografts.Carcinogenesis2007 AprChen G-
24909164SIRT3 regulates cellular iron metabolism and cancer growth by repressing iron regulatory protein 1.Oncogene2015 Apr 16Jeong SMdoi: 10.1038/onc.2014.124
26755275Circulating Metabolites and Survival Among Patients With Pancreatic Cancer.J Natl Cancer Inst2016 Jan 11Yuan Cdoi: 10.1093/jnci/djv409

Differential Expression

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
ACCchr932430446Missense_MutationnovelS533Y0.12
BLCAchr932408533Missense_MutationnovelD96H0.47
BLCAchr932448893Splice_Regionrs7580615240.41
BLCAchr932450099Missense_MutationNAK886N0.3
BLCAchr932425901Missense_MutationnovelD418N0.19
BLCAchr932421008Silentrs750587886I317I0.23
BLCAchr932431750SilentnovelL586L0.41
BLCAchr932430449Missense_MutationnovelG534E0.18
BLCAchr932407328SilentnovelV55V0.53
BLCAchr932436263Missense_MutationnovelE705Q0.37Aconitase
BRCAchr932418456Silentrs139223145L201L0.09
BRCAchr932427429Nonsense_MutationnovelQ493*0.34
BRCAchr932419094Missense_MutationnovelL239F0.08
BRCAchr932425978Silentrs112535632P443P0.74
BRCAchr932431801SilentNAY603Y0.3
CESCchr932419139Missense_MutationNAL254V0.13
CESCchr932418335Missense_MutationNAS161F0.18
CESCchr932423399Missense_MutationnovelQ351E0.5
CESCchr932423412Missense_MutationnovelF355S0.38
COADchr932405521Silentrs772130307F5F0.31
COADchr932405563Missense_Mutationrs376599072K19N0.21
COADchr9324503003'UTRnovel0.21
COADchr932436390Missense_MutationNAG747E0.3Aconitase
COADchr932423347Frame_Shift_InsNAY336Ifs*130.32
COADchr932424624Missense_MutationNAS383P0.26
COADchr932434574Frame_Shift_DelNAP659Lfs*40.24
COADchr932418471Silentrs371235086S206S0.4
COADchr9324055035'UTRnovel0.18
COADchr932434661Missense_MutationNAA687T0.1
COADchr932449014Missense_MutationNAT830I0.19
COADchr932423349Missense_MutationNAK334T0.13
COADchr932405521Silentrs772130307F5F0.16
COADchr932418192Missense_MutationnovelL157V0.03
COADchr932418180Nonsense_Mutationrs142015075R153*0.22
DLBCchr932430459Missense_MutationnovelN537K0.04
GBMchr932430544Missense_MutationnovelI566F0.07
GBMchr932430437Missense_MutationNAG530V0.45
GBMchr932429464Missense_MutationnovelS510R0.05
GBMchr932405522Missense_Mutationrs201900147A6T0.39
GBMchr932431733Missense_MutationnovelG581R0.05
GBMchr932419134Missense_MutationnovelH252P0.3
GBMchr932419042Silentrs199543469V221V0.21
HNSCchr932418478Missense_MutationnovelT209A0.24
HNSCchr932420931Missense_MutationnovelD292N0.06
HNSCchr932448902Frame_Shift_DelnovelA794Pfs*200.6Aconitase
HNSCchr932407407Missense_MutationnovelR82C0.22
HNSCchr932407280Missense_MutationnovelI39M0.13
HNSCchr932423394Missense_MutationnovelP349L0.12
HNSCchr932436285Missense_Mutationrs376485136R712H0.26Aconitase
HNSCchr932423411Missense_MutationnovelF355V0.06
KIRCchr932434669SilentNAN689N0.2
KIRCchr932408578Missense_MutationNAP111T0.18
KIRCchr932433774Missense_MutationnovelL633Q0.39
KIRCchr932425991Missense_MutationNAG448R0.26
KIRPchr932448944Missense_MutationNAN807Y0.39Aconitase
LAMLchr932448987Missense_MutationnovelG821V0.1
LAMLchr932423365SilentnovelA339A0.07
LAMLchr932433752Missense_MutationnovelL626I0.06
LGGchr932408518Missense_MutationnovelV91M0.07
LIHCchr932450105SilentnovelA888A0.47
LIHCchr932424549Missense_Mutationrs774323213V358I0.06
LIHCchr932431731Missense_MutationnovelK580R0.47
LIHCchr932430522SilentnovelI558I0.47
LIHCchr932418352Missense_MutationNAM167V0.16
LUADchr932407430Splice_SiteNAX89_splice0.14
LUADchr932430488Missense_Mutationrs551232686R547Q0.27
LUADchr932424651Missense_MutationNAC392S0.26
LUADchr932436256SilentnovelT702T0.12
LUADchr932436254Missense_MutationNAT702S0.19Aconitase
LUADchr932407430Splice_SiteNAX89_splice0.09
LUADchr932434698Missense_MutationnovelR699K0.06Aconitase
LUADchr932421017SilentNAL320L0.1
LUSCchr932436271Missense_MutationnovelN707K0.05Aconitase
LUSCchr932431750SilentnovelL586L0.24
LUSCchr932448967Missense_MutationNAI814M0.36Aconitase
LUSCchr932436335SilentnovelL729L0.28
LUSCchr932408524Missense_Mutationrs758468204A93T0.12
OVchr932418433Nonsense_MutationnovelG194*0.03
OVchr932448992Missense_MutationnovelN823H0.51
OVchr932448959Missense_MutationnovelG812C0.03Aconitase
OVchr932407297Missense_MutationnovelA45E0.03
OVchr932418166Missense_MutationnovelE148V0.16
OVchr932418167Nonsense_MutationnovelR149Afs*90.14
PRADchr932427364Missense_MutationNAL471P0.19
PRADchr932408560Missense_MutationnovelK105E0.11
PRADchr932440539Silentrs183113769Y774Y0.35
READchr932407370Silentrs751872663T69T0.4
READchr932431756Frame_Shift_InsNAI589Nfs*50.41
SARCchr932407430Splice_SiteNAX89_splice0.43
SARCchr932418331Missense_MutationnovelG160S0.19
SARCchr932440488Missense_MutationnovelE757D0.13Aconitase
SKCMchr9324055065'UTRnovel0.29
SKCMchr932407276Missense_Mutationrs537741206S38L0.19
SKCMchr932430511Missense_MutationnovelP555S0.81
SKCMchr932419076Nonsense_MutationNAQ233*0.53
SKCMchr932405521Silentrs772130307F5F0.19
SKCMchr932419042Silentrs199543469V221V0.38
SKCMchr932449073Nonsense_MutationNAQ850*0.67
SKCMchr932407276Missense_Mutationrs537741206S38L0.81
SKCMchr932430470Missense_Mutationrs752397721R541Q0.18
SKCMchr932431823Missense_MutationNAE611K0.27
SKCMchr932424654Missense_MutationnovelL393F0.49
SKCMchr932448915Missense_MutationNAA797V0.46Aconitase
SKCMchr9324501703'UTRnovel0.83
SKCMchr932419036Splice_Siters747105232X220_splice0.58
STADchr9324501163'UTRnovel0.41
STADchr932431793Missense_Mutationrs757678488R601C0.16
STADchr932421000Frame_Shift_InsnovelS316*0.32
STADchr932450069Silentrs754642961N876N0.07
STADchr932407349SilentnovelN62N0.05
STADchr932427425SilentnovelL491L0.28
STADchr932418457Missense_MutationNAV202M0.23
STADchr932436324Missense_MutationNAA725V0.18Aconitase
STADchr9324501293'UTRnovel0.35
STADchr932418457Missense_MutationNAV202M0.04
STADchr932423342Missense_MutationNAY332H0.06
STADchr932430506Missense_MutationNAS553F0.45
UCECchr932418181Missense_Mutationrs199823143R153Q0.49
UCECchr932433768Missense_MutationNAD631G0.25
UCECchr932427385Missense_MutationnovelV478A0.16
UCECchr9324501493'UTRrs3723299500.21
UCECchr932424624Missense_MutationNAS383A0.26
UCECchr932430553Missense_Mutationrs776806842D569N0.1
UCECchr932449012SilentNAL829L0.19
UCECchr932418146Missense_MutationNAK141N0.36
UCECchr9324503103'UTRnovel0.8
UCECchr9324501643'UTRrs5773585480.41
UCECchr932425909SilentNAT420T0.36
UCECchr932424556Missense_MutationNAE360G0.39
UCECchr932436284Missense_Mutationrs764953534R712C0.32Aconitase
UCECchr932425977Missense_Mutationrs776431987P443L0.51
UCECchr932430553Missense_Mutationrs776806842D569N0.32
UCECchr932427338Silentrs376893104N462N0.33
UCECchr932450070Missense_Mutationrs764702759G877R0.33
UCECchr932425858Silentrs748250321Q403Q0.52
UCECchr932418474Silentrs772171891H207H0.41
UCECchr932407317Nonsense_MutationNAE52*0.23
UCECchr932423381Missense_MutationNAD345Y0.11
UCECchr932436332Missense_Mutationrs748369667R728C0.16Aconitase
UCECchr932450094Missense_Mutationrs112153542R885C0.34
UCECchr932448916Silentrs776083510A797A0.38
UCECchr9324502543'UTRnovel0.1
UCECchr932431736Nonsense_MutationNAQ582*0.11
UCECchr932434563Missense_MutationnovelL654S0.08
UCECchr9324503103'UTRnovel0.38
UCECchr932407319Frame_Shift_InsnovelL54Ffs*80.25
UCECchr932430431Missense_MutationnovelA528V0.35
UCECchr932418494Missense_MutationnovelL214S0.32
UCECchr932419049Missense_MutationNAI224V0.53
UCECchr932425991Missense_MutationNAG448R0.13
UCECchr932430503Missense_MutationNAA552V0.19
UCECchr932423330Nonsense_MutationnovelE328*0.33
UCECchr932418169Missense_MutationnovelR149I0.33
UCECchr932433760SilentnovelT628T0.29
UCECchr932418355Missense_Mutationrs41305321R168W0.3
UCECchr932431828SilentnovelV612V0.4
UCECchr932436298Silentrs777247934D716D0.34
UCECchr932407379Missense_MutationnovelK72N0.43
UCECchr9324502773'UTRnovel0.13
UCECchr932429451Frame_Shift_InsnovelI507Kfs*170.04
UCECchr932420966Silentrs370738336Y303Y0.31
UCECchr932429453In_Frame_InsnovelI507delinsKL0.05
UCECchr932429454In_Frame_InsnovelI507_G508insHLPGSCHSP0.05
UCECchr932431828Frame_Shift_InsnovelY613Rfs*100.08
UCECchr932427402Nonsense_MutationnovelE484*0.11
UCECchr932449035Missense_MutationnovelI837T0.2
UCECchr932433798Missense_Mutationrs770368084T641M0.44
UCECchr932430553Missense_Mutationrs776806842D569N0.39
UCECchr932440539Silentrs183113769Y774Y0.36
UCECchr932407331Missense_MutationnovelK56N0.17
UCECchr932450103Missense_MutationnovelA888T0.21
UCECchr932405569SilentNAF21F0.36
UCECchr932423331Frame_Shift_DelnovelK329Nfs*20.18
UCECchr932433798Missense_Mutationrs770368084T641M0.3
UCECchr932429453Frame_Shift_InsnovelI507Kfs*240.07
UCECchr932429453Frame_Shift_InsnovelI507Kfs*240.04
UCECchr932436334SilentNAR728R0.12
UCECchr932423396Missense_MutationNAS350P0.11
UCECchr932419042Silentrs199543469V221V0.28
UCECchr932423379Missense_Mutationrs773392518R344Q0.5
UCECchr932408620Missense_MutationnovelD125Y0.41
UCECchr932429453In_Frame_InsnovelI507delinsKL0.03
UCECchr932429454Frame_Shift_InsnovelG508Hfs*130.03
UCECchr932407277Silentrs754861122S38S0.25
UCECchr932418356Missense_Mutationrs774234584R168Q0.17
UCECchr932421017SilentnovelL320L0.22
UCECchr932436327Missense_MutationnovelN726S0.39Aconitase
UCECchr932424623SilentnovelV382V0.08
UCECchr932421025Missense_MutationnovelT323I0.37

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
LAMLDEL0.00520.24147
TGCTDEL0.327.3329e-05
THCADEL0.02610.24038
THYMDEL0.02440.022012

Survival Analysis
CancerP-value Q-value
THYM0.019

Kaplan-Meier Survival Analysis

KIRC0.00011

Kaplan-Meier Survival Analysis

MESO0.0095

Kaplan-Meier Survival Analysis

UCS0.0068

Kaplan-Meier Survival Analysis

HNSC0.035

Kaplan-Meier Survival Analysis

LIHC0.013

Kaplan-Meier Survival Analysis

DLBC0.021

Kaplan-Meier Survival Analysis

LGG0.00011

Kaplan-Meier Survival Analysis

LUAD0.05

Kaplan-Meier Survival Analysis

UVM0.035

Kaplan-Meier Survival Analysis

Drugs

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Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBDs
  • RBPome
  • Literatures
  • Expression
  • Transcripts
  • Gene Model
  • Pathways
  • Phenotypes
  • GWAS
  • PPI
  • Paralogs
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000122729 (Gene tree)
Gene ID
48
Gene Symbol
ACO1
Alias
IRP1|IREBP|IREB1
Full Name
aconitase 1
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Plus strand
Length
70,167 bases
Position
chr9:32,384,603-32,454,769
Accession
117
RBP type
canonical RBP
Summary
The protein encoded by this gene is a bifunctional, cytosolic protein that functions as an essential enzyme in the TCA cycle and interacts with mRNA to control the levels of iron inside cells. When cellular iron levels are high, this protein binds to a 4Fe-4S cluster and functions as an aconitase. Aconitases are iron-sulfur proteins that function to catalyze the conversion of citrate to isocitrate. When cellular iron levels are low, the protein binds to iron-responsive elements (IREs), which are stem-loop structures found in the 5' UTR of ferritin mRNA, and in the 3' UTR of transferrin receptor mRNA. When the protein binds to IRE, it results in repression of translation of ferritin mRNA, and inhibition of degradation of the otherwise rapidly degraded transferrin receptor mRNA. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Alternative splicing results in multiple transcript variants [provided by RefSeq, Jan 2014]
RNA binding domains(RBDs)
Protein IDDomain Pfam IDE-value Domain number Total number
ENSP00000309477AconitasePF00330.201.8e-18011
ENSP00000369255AconitasePF00330.201.8e-18011
ENSP00000438733AconitasePF00330.201.8e-18011
ENSP00000309477Aconitase_CPF00694.196.1e-4611
ENSP00000369255Aconitase_CPF00694.196.1e-4611
ENSP00000438733Aconitase_CPF00694.196.1e-4611
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
29431736Capturing the interactome of newly transcribed RNAPolyT-RICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & U2OS2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
9988751Hypoxia post-translationally activates iron-regulatory protein 2.J Biol Chem1999 Feb 19Hanson ES-
8961933Expression and biochemical characterization of iron regulatory proteins 1 and 2 in Saccharomyces cerevisiae.Biochemistry1996 Dec 10Phillips JD-
7665579Iron regulates the intracellular degradation of iron regulatory protein 2 by the proteasome.J Biol Chem1995 Sep 15Guo B-
12855587Effects of iron regulatory protein regulation on iron homeostasis during hypoxia.Blood2003 Nov 1Schneider BD-
10704227Nitrogen monoxide activates iron regulatory protein 1 RNA-binding activity by two possible mechanisms: effect on the [4Fe-4S] cluster and iron mobilization from cells.Biochemistry2000 Mar 14Wardrop SL-
25120486The IRP/IRE system in vivo: insights from mouse models.Front Pharmacol2014 Jul 28Wilkinson Ndoi: 10.3389/fphar.2014.00176
23935819Novel 5' untranslated region directed blockers of iron-regulatory protein-1 dependent amyloid precursor protein translation: implications for down syndrome and Alzheimer's disease.PLoS One2013 Jul 31Bandyopadhyay Sdoi: 10.1371/journal.pone.0065978
24728987Rapid kinetics of iron responsive element (IRE) RNA/iron regulatory protein 1 and IRE-RNA/eIF4F complexes respond differently to metal ions.Nucleic Acids Res2014 JunKhan MAdoi: 10.1093/nar/gku248
8633068Differences in the RNA binding sites of iron regulatory proteins and potential target diversity.Proc Natl Acad Sci U S A1996 Apr 30Butt J-
9516462Regulation of iron regulatory protein 1 during hypoxia and hypoxia/reoxygenation.J Biol Chem1998 Mar 27Hanson ES-
16914832Preliminary demonstration of an allelic association of the IREB2 gene with Alzheimer's disease.J Alzheimers Dis2006 AugCoon KD-
12429122Structured RNA upstream of insect cap distal iron responsive elements enhances iron regulatory protein-mediated control of translation.Insect Biochem Mol Biol2002 DecNichol H-
11238861Mitochondrial aconitase binds to the 3' untranslated region of the mouse hepatitis virus genome.J Virol2001 AprNanda SK-
8710843Molecular control of vertebrate iron metabolism: mRNA-based regulatory circuits operated by iron, nitric oxide, and oxidative stress.Proc Natl Acad Sci U S A1996 Aug 6Hentze MW-
7890603Translational repressor activity is equivalent and is quantitatively predicted by in vitro RNA binding for two iron-responsive element-binding proteins, IRP1 and IRP2.J Biol Chem1995 Mar 10Kim HY-
12572672Role of nitric oxide in cellular iron metabolism.Biometals2003 MarKim S-
12547230Nitric oxide-mediated modulation of iron regulatory proteins: implication for cellular iron homeostasis.Blood Cells Mol Dis2002 Nov-DecKim S-
10816424Oxalomalate, a competitive inhibitor of aconitase, modulates the RNA-binding activity of iron-regulatory proteins.Biochem J2000 Jun 1Festa M-
10692416Effects of interferon-gamma and lipopolysaccharide on macrophage iron metabolism are mediated by nitric oxide-induced degradation of iron regulatory protein 2.J Biol Chem2000 Mar 3Kim S-
14726953Genetic ablations of iron regulatory proteins 1 and 2 reveal why iron regulatory protein 2 dominates iron homeostasis.EMBO J2004 Jan 28Meyron-Holtz EG-
19021541Iron and the translation of the amyloid precursor protein (APP) and ferritin mRNAs: riboregulation against neural oxidative damage in Alzheimer's disease.Biochem Soc Trans2008 DecRogers JTdoi: 10.1042/BST0361282.
25548934Electrophoretic mobility shift assay (EMSA) for the study of RNA-protein interactions: the IRE/IRP example.J Vis Exp2014 Dec 3Fillebeen Cdoi: 10.3791/52230.
10545118Identification of RNA-binding surfaces in iron regulatory protein-1.EMBO J1999 Nov 1Kaldy P-
7544791Differential modulation of the RNA-binding proteins IRP-1 and IRP-2 in response to iron. IRP-2 inactivation requires translation of another protein.J Biol Chem1995 Sep 1Henderson BR-
7489724Requirements for iron-regulated degradation of the RNA binding protein, iron regulatory protein 2.EMBO J1995 Nov 1Iwai K-
10095770Iron regulatory protein as an endogenous sensor of iron in rat intestinal mucosa. Possible implications for the regulation of iron absorption.Eur J Biochem1999 MarSchumann K-
10070739An atypical iron-responsive element (IRE) within crayfish ferritin mRNA and an iron regulatory protein 1 (IRP1)-like protein from crayfish hepatopancreas.Insect Biochem Mol Biol1999 JanHuang TS-
10037708Inactivation of both RNA binding and aconitase activities of iron regulatory protein-1 by quinone-induced oxidative stress.J Biol Chem1999 Mar 5Gehring NH-
9867873Thioredoxin activation of iron regulatory proteins. Redox regulation of RNA binding after exposure to nitric oxide.J Biol Chem1999 Jan 1Oliveira L-
9868172Iron regulatory proteins, iron responsive elements and iron homeostasis.J Nutr1998 DecEisenstein RS-
9660175Iron-regulatory protein-1 (IRP-1) is highly conserved in two invertebrate species--characterization of IRP-1 homologues in Drosophila melanogaster and Caenorhabditis elegans.Eur J Biochem1998 Jun 1Muckenthaler M-
9545264Converse modulation of IRP1 and IRP2 by immunological stimuli in murine RAW 264.7 macrophages.J Biol Chem1998 Apr 17Bouton C-
9482759Dietary iron intake rapidly influences iron regulatory proteins, ferritin subunits and mitochondrial aconitase in rat liver.J Nutr1998 MarChen OS-
9380695Iron regulatory protein 1 is not required for the modulation of ferritin and transferrin receptor expression by iron in a murine pro-B lymphocyte cell line.Proc Natl Acad Sci U S A1997 Sep 30Schalinske KL-
9242665Redox modulation of iron regulatory proteins by peroxynitrite.J Biol Chem1997 Aug 8Bouton C-
9115286Resistance to the antitumor agent gallium nitrate in human leukemic cells is associated with decreased gallium/iron uptake, increased activity of iron regulatory protein-1, and decreased ferritin production.J Biol Chem1997 May 2Chitambar CR-
9092514Differences in the regulation of iron regulatory protein-1 (IRP-1) by extra- and intracellular oxidative stress.J Biol Chem1997 Apr 11Pantopoulos K-
9092825The iron-sulfur cluster of iron regulatory protein 1 modulates the accessibility of RNA binding and phosphorylation sites.Biochemistry1997 Apr 1Schalinske KL-
10440237Regulation of the iron regulatory proteins by reactive nitrogen and oxygen species.Gene Expr1999Hanson ES-
9039823Dietary iron intake modulates the activity of iron regulatory proteins and the abundance of ferritin and mitochondrial aconitase in rat liver.J Nutr1997 FebChen OS-
8994263Interaction between iron-regulatory proteins and their RNA target sequences, iron-responsive elements.Prog Mol Subcell Biol1997Henderson BR-
8977218Pathways for the regulation of macrophage iron metabolism by the anti-inflammatory cytokines IL-4 and IL-13.J Immunol1997 Jan 1Weiss G-
8874195Nitric oxide alters the expression of gamma-globin, H-ferritin, and transferrin receptor in human K562 cells at the posttranscriptional level.Blood1996 Oct 15Domachowske JB-
10419470Human cytoplasmic aconitase (Iron regulatory protein 1) is converted into its [3Fe-4S] form by hydrogen peroxide in vitro but is not activated for iron-responsive element binding.J Biol Chem1999 Jul 30Brazzolotto X-
8706708Conservation of aconitase residues revealed by multiple sequence analysis. Implications for structure/function relationships.Eur J Biochem1996 Jul 1Frishman D-
8617762Iron regulatory proteins 1 and 2 bind distinct sets of RNA target sequences.J Biol Chem1996 Mar 1Henderson BR-
8639920Differential regulation of IRP1 and IRP2 by nitric oxide in rat hepatoma cells.Blood1996 Apr 1Phillips JD-
10329709Ligand-induced structural alterations in human iron regulatory protein-1 revealed by protein footprinting.J Biol Chem1999 May 21Gegout V-
7622457Characterization and expression of iron regulatory protein 2 (IRP2). Presence of multiple IRP2 transcripts regulated by intracellular iron levels.J Biol Chem1995 Jul 14Guo B-
16923907Bacillus subtilis aconitase is required for efficient late-sporulation gene expression.J Bacteriol2006 SepSerio AW-
12972424Compartment-specific protection of iron-sulfur proteins by superoxide dismutase.J Biol Chem2003 Nov 28Missirlis F-
12746546Iron regulatory proteins as NO signal transducers.Sci STKE2003 May 13Bouton C-
12592010A high-capacity RNA affinity column for the purification of human IRP1 and IRP2 overexpressed in Pichia pastoris.RNA2003 MarAllerson CR-
12581865Interactions between doxorubicin and the human iron regulatory system.Biochim Biophys Acta2003 Feb 17Brazzolotto X-
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16511314Crystallization and preliminary X-ray diffraction analysis of iron regulatory protein 1 in complex with ferritin IRE RNA.Acta Crystallogr Sect F Struct Biol Cryst Commun2006 Mar 1Selezneva AI-
12438312Cytosolic aconitase and ferritin are regulated by iron in Caenorhabditis elegans.J Biol Chem2003 Jan 31Gourley BL-
12196178Down-regulation of liver iron-regulatory protein 1 in haemochromatosis.Biochem Soc Trans2002 AugNeonaki M-
16479012Sodium nitroprusside promotes IRP2 degradation via an increase in intracellular iron and in the absence of S nitrosylation at C178.Mol Cell Biol2006 MarWang J-
12065670Impact of endogenous nitric oxide on microglial cell energy metabolism and labile iron pool.J Neurochem2002 MayChenais B-
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11969379Role of hypolipidemic drug clofibrate in altering iron regulatory proteins IRP1 and IRP2 activities and hepatic iron metabolism in rats fed a low-iron diet.Toxicol Appl Pharmacol2002 Apr 15Huang HL-
11807826Increased IRP1 and IRP2 RNA binding activity accompanies a reduction of the labile iron pool in HFE-expressing cells.J Cell Physiol2002 FebRoy CN-
16424901Iron-responsive degradation of iron-regulatory protein 1 does not require the Fe-S cluster.EMBO J2006 Feb 8Clarke SL-
11301321Intracellular chelation of iron by bipyridyl inhibits DNA virus replication: ribonucleotide reductase maturation as a probe of intracellular iron pools.J Biol Chem2001 Jun 29Romeo AM-
11054110Interferon-gamma and lipopolysaccharide regulate the expression of Nramp2 and increase the uptake of iron from low relative molecular mass complexes by macrophages.Eur J Biochem2000 NovWardrop SL-
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10978328Overexpression of H ferritin and up-regulation of iron regulatory protein genes during differentiation of 3T3-L1 pre-adipocytes.J Biol Chem2000 Nov 24Festa M-
10913165Coordinate transcriptional and translational regulation of ferritin in response to oxidative stress.Mol Cell Biol2000 AugTsuji Y-
10823926Down-regulation of iron regulatory protein 1 gene expression by nitric oxide.Proc Natl Acad Sci U S A2000 Jun 6Oliveira L-
16886906STAT5 proteins are involved in down-regulation of iron regulatory protein 1 gene expression by nitric oxide.Biochem J2006 Dec 1Starzynski RR-
16819431[The role of iron regulatory proteins (IRPs) in the regulation of systemic iron homeostasis: lessons from studies on IRP1 and IRP2 knock out mice].Postepy Hig Med Dosw (Online)2006Lipinski P-
16828896Induction of H-ferritin synthesis by oxalomalate is regulated at both the transcriptional and post-transcriptional levels.Biochim Biophys Acta2006 AugSantamaria R-
15629469Induction of iron regulatory protein 1 RNA-binding activity by nitric oxide is associated with a concomitant increase in the labile iron pool: implications for DNA damage.Biochem Biophys Res Commun2005 Feb 4Lipinski P-
15636585IRP1 Ser-711 is a phosphorylation site, critical for regulation of RNA-binding and aconitase activities.Biochem J2005 May 15Fillebeen C-
15615771Friedreich ataxia: the oxidative stress paradox.Hum Mol Genet2005 Feb 15Seznec H-
16787928RNA silencing of mitochondrial m-Nfs1 reduces Fe-S enzyme activity both in mitochondria and cytosol of mammalian cells.J Biol Chem2006 Sep 1Fosset C-
15271519Zinc and cadmium specifically interfere with RNA-binding activity of human iron regulatory protein 1.J Inorg Biochem2004 AugMartelli A-
15158359Differential effects on cellular iron metabolism of the physiologically relevant diatomic effector molecules, NO and CO, that bind iron.Biochim Biophys Acta2004 May 28Watts RN-
15110995Induction of ferritin expression by oxalomalate.Biochim Biophys Acta2004 May 3Santamaria R-
16737972Alcohol metabolism-mediated oxidative stress down-regulates hepcidin transcription and leads to increased duodenal iron transporter expression.J Biol Chem2006 Aug 11Harrison-Findik DD-
14705945Blotting analysis of native IRP1: a novel approach to distinguish the different forms of IRP1 in cells and tissues.Biochemistry2004 Jan 13Campanella A-
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17760563Human iron regulatory protein 2 is easily cleaved in its specific domain: consequences for the haem binding properties of the protein.Biochem J2007 Dec 15Dycke C-
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Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000309951ACO1-2017466XM_011517888ENSP00000309477889 (aa)XP_011516190P21399
ENST00000541043ACO1-2033618-ENSP00000438733889 (aa)-P21399
ENST00000379923ACO1-2023601XM_005251476ENSP00000369255889 (aa)XP_005251533P21399
Gene Model
Click here to download ENSG00000122729's gene model file
Pathways
Pathway IDPathway NameSource
hsa00020Citrate cycle (TCA cycle)KEGG
hsa00630Glyoxylate and dicarboxylate metabolismKEGG
hsa01100Metabolic pathwaysKEGG
hsa01200Carbon metabolismKEGG
hsa012102-Oxocarboxylic acid metabolismKEGG
hsa01230Biosynthesis of amino acidsKEGG
Phenotypes
ensgIDTraitpValuePubmed ID
ENSG00000122729Myocardial Infarction3.8807257E-004-
ENSG00000122729Myocardial Infarction4.3904345E-004-
ENSG00000122729Myocardial Infarction3.7377826E-005-
ENSG00000122729Heart Failure4.3032748E-004-
ENSG00000122729Coronary Artery Disease4.6210000E-005-
ENSG00000122729Psoriasis4E-925574825
ENSG00000122729Asthma4E-622561531
ENSG00000122729Immunoglobulins5E-623382691
GWAS
ensgIDSNPChromosomePositionSNP-risk TraitPubmedID95% CIOr or BEAT EFO ID
ENSG00000122729rs4878497932432976?Inflammatory skin disease25574825EFO_0000676
ENSG00000122729rs7032871932422692TIgG glycosylation23382691[0.09-0.226] unit increase0.1579EFO_0005193
ENSG00000122729rs10970976932433528?Asthma22561531[1.16-1.43]1.28EFO_0000270
ENSG00000122729rs77802813932436905ABlood protein levels30072576[0.085-0.219] unit decrease0.152EFO_0007937
ENSG00000122729rs10970975932431933?Red blood cell count30595370EFO_0004305
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000122729's network

* RBP PPI network refers to all genes directly bind to RBP
Paralogs
Ensembl IDGene SymbolCoverageIdentiy ParalogGene SymbolCoverageIdentiy
ENSG00000122729ACO19953.918ENSG00000136381IREB210064.103
Orthologs
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000122729ACO110082.002ENSAPOG00000008670aco19982.002Acanthochromis_polyacanthus
ENSG00000122729ACO110093.258ENSAMEG00000003746ACO110093.258Ailuropoda_melanoleuca
ENSG00000122729ACO110082.340ENSACIG00000014377aco19982.340Amphilophus_citrinellus
ENSG00000122729ACO110082.002ENSAOCG00000007699aco19982.002Amphiprion_ocellaris
ENSG00000122729ACO110082.115ENSAPEG00000014370aco19982.115Amphiprion_percula
ENSG00000122729ACO19983.333ENSATEG00000000560aco19983.333Anabas_testudineus
ENSG00000122729ACO19987.725ENSAPLG00000015490ACO19987.725Anas_platyrhynchos
ENSG00000122729ACO19786.512ENSACAG00000001541ACO19986.512Anolis_carolinensis
ENSG00000122729ACO19996.622ENSANAG00000003359ACO19996.622Aotus_nancymaae
ENSG00000122729ACO110081.777ENSACLG00000007755aco19981.777Astatotilapia_calliptera
ENSG00000122729ACO19982.545ENSAMXG00000002499aco19982.545Astyanax_mexicanus
ENSG00000122729ACO110094.263ENSBTAG00000000555ACO110094.263Bos_taurus
ENSG00000122729ACO110097.188ENSCJAG00000007687ACO110097.188Callithrix_jacchus
ENSG00000122729ACO110093.146ENSCAFG00000001786ACO19993.146Canis_familiaris
ENSG00000122729ACO110093.251ENSCAFG00020014553ACO110093.251Canis_lupus_dingo
ENSG00000122729ACO110094.038ENSCHIG00000007667ACO110094.038Capra_hircus
ENSG00000122729ACO110096.063ENSTSYG00000004179ACO19996.063Carlito_syrichta
ENSG00000122729ACO110074.016ENSCAPG00000007254ACO110074.016Cavia_aperea
ENSG00000122729ACO110092.913ENSCPOG00000003768ACO110092.913Cavia_porcellus
ENSG00000122729ACO110096.625ENSCCAG00000022465ACO110096.625Cebus_capucinus
ENSG00000122729ACO110098.425ENSCATG00000045333ACO110098.425Cercocebus_atys
ENSG00000122729ACO110092.238ENSCLAG00000002487ACO110092.238Chinchilla_lanigera
ENSG00000122729ACO110098.313ENSCSAG00000009824ACO19998.313Chlorocebus_sabaeus
ENSG00000122729ACO19076.831ENSCHOG00000008996ACO19076.831Choloepus_hoffmanni
ENSG00000122729ACO19988.626ENSCPBG00000008077ACO19988.626Chrysemys_picta_bellii
ENSG00000122729ACO110098.425ENSCANG00000014847ACO110098.425Colobus_angolensis_palliatus
ENSG00000122729ACO110094.601ENSCGRG00001024337Aco110094.601Cricetulus_griseus_chok1gshd
ENSG00000122729ACO110093.363ENSCGRG00000004877-10093.363Cricetulus_griseus_crigri
ENSG00000122729ACO19978.153ENSCSEG00000018262aco19978.153Cynoglossus_semilaevis
ENSG00000122729ACO19976.351ENSCVAG00000020264aco19976.351Cyprinodon_variegatus
ENSG00000122729ACO110082.340ENSDARG00000026376aco19982.340Danio_rerio
ENSG00000122729ACO110094.263ENSDNOG00000003951ACO110094.263Dasypus_novemcinctus
ENSG00000122729ACO110093.926ENSDORG00000014246Aco110093.926Dipodomys_ordii
ENSG00000122729ACO18672.487ENSETEG00000012415-8572.487Echinops_telfairi
ENSG00000122729ACO19958.855ENSEBUG00000015441aco19758.855Eptatretus_burgeri
ENSG00000122729ACO110095.388ENSEASG00005004602ACO110095.388Equus_asinus_asinus
ENSG00000122729ACO110095.276ENSECAG00000014846ACO110095.276Equus_caballus
ENSG00000122729ACO110082.452ENSEEUG00000015174ACO110082.452Erinaceus_europaeus
ENSG00000122729ACO110081.215ENSELUG00000016812aco19781.215Esox_lucius
ENSG00000122729ACO110094.038ENSFCAG00000001293ACO110094.038Felis_catus
ENSG00000122729ACO19987.162ENSFALG00000001167ACO19987.162Ficedula_albicollis
ENSG00000122729ACO110094.376ENSFDAG00000016058ACO110094.376Fukomys_damarensis
ENSG00000122729ACO19982.525ENSFHEG00000005619aco19982.525Fundulus_heteroclitus
ENSG00000122729ACO19978.805ENSGMOG00000005514aco19978.805Gadus_morhua
ENSG00000122729ACO19987.613ENSGALG00000002162ACO19987.613Gallus_gallus
ENSG00000122729ACO19981.511ENSGACG00000001637aco19981.511Gasterosteus_aculeatus
ENSG00000122729ACO19988.063ENSGAGG00000023315ACO19988.063Gopherus_agassizii
ENSG00000122729ACO110099.775ENSGGOG00000016306ACO110099.775Gorilla_gorilla
ENSG00000122729ACO110081.890ENSHBUG00000008952aco19981.890Haplochromis_burtoni
ENSG00000122729ACO110094.601ENSHGLG00000018922Aco110094.601Heterocephalus_glaber_female
ENSG00000122729ACO110094.601ENSHGLG00100000149Aco110094.601Heterocephalus_glaber_male
ENSG00000122729ACO19978.941ENSHCOG00000015881aco19978.941Hippocampus_comes
ENSG00000122729ACO110082.002ENSIPUG00000020088ACO19982.002Ictalurus_punctatus
ENSG00000122729ACO110095.051ENSSTOG00000006942ACO19995.051Ictidomys_tridecemlineatus
ENSG00000122729ACO110094.263ENSJJAG00000013824Aco110094.263Jaculus_jaculus
ENSG00000122729ACO19981.172ENSKMAG00000015759aco19981.172Kryptolebias_marmoratus
ENSG00000122729ACO110078.202ENSLBEG00000013866aco19978.202Labrus_bergylta
ENSG00000122729ACO17573.145ENSLACG00000000936ACO19973.294Latimeria_chalumnae
ENSG00000122729ACO19984.442ENSLOCG00000011082aco19984.442Lepisosteus_oculatus
ENSG00000122729ACO110093.026ENSLAFG00000013470ACO110093.026Loxodonta_africana
ENSG00000122729ACO110098.875ENSMFAG00000001702ACO110098.875Macaca_fascicularis
ENSG00000122729ACO110098.988ENSMMUG00000008196ACO110098.988Macaca_mulatta
ENSG00000122729ACO110098.763ENSMNEG00000045040ACO110098.763Macaca_nemestrina
ENSG00000122729ACO110098.763ENSMLEG00000005636ACO110098.763Mandrillus_leucophaeus
ENSG00000122729ACO110083.127ENSMAMG00000002915aco19983.127Mastacembelus_armatus
ENSG00000122729ACO19978.387ENSMZEG00005012733aco19978.387Maylandia_zebra
ENSG00000122729ACO19971.987ENSMGAG00000008851ACO19971.987Meleagris_gallopavo
ENSG00000122729ACO110094.038ENSMAUG00000021408Aco110094.038Mesocricetus_auratus
ENSG00000122729ACO110095.051ENSMICG00000006540ACO110095.051Microcebus_murinus
ENSG00000122729ACO110094.038ENSMOCG00000015393Aco110094.038Microtus_ochrogaster
ENSG00000122729ACO110081.102ENSMMOG00000020282aco19981.102Mola_mola
ENSG00000122729ACO110090.889ENSMODG00000004463ACO110090.889Monodelphis_domestica
ENSG00000122729ACO110082.340ENSMALG00000019764aco19982.340Monopterus_albus
ENSG00000122729ACO110093.813MGP_CAROLIEiJ_G0025892Aco110093.813Mus_caroli
ENSG00000122729ACO110093.363ENSMUSG00000028405Aco110093.363Mus_musculus
ENSG00000122729ACO110093.701MGP_PahariEiJ_G0024015Aco110093.701Mus_pahari
ENSG00000122729ACO110093.476MGP_SPRETEiJ_G0026841Aco110093.476Mus_spretus
ENSG00000122729ACO110093.701ENSMPUG00000004340ACO110093.701Mustela_putorius_furo
ENSG00000122729ACO110093.026ENSMLUG00000003029ACO110093.026Myotis_lucifugus
ENSG00000122729ACO110094.826ENSNGAG00000005703Aco110094.826Nannospalax_galili
ENSG00000122729ACO110064.206ENSNBRG00000008973aco19964.206Neolamprologus_brichardi
ENSG00000122729ACO110098.988ENSNLEG00000003409ACO110098.988Nomascus_leucogenys
ENSG00000122729ACO19083.144ENSMEUG00000014756ACO19083.144Notamacropus_eugenii
ENSG00000122729ACO110089.876ENSOPRG00000016791ACO110089.876Ochotona_princeps
ENSG00000122729ACO110091.901ENSODEG00000001240-10091.901Octodon_degus
ENSG00000122729ACO110089.314ENSODEG00000015432-10089.314Octodon_degus
ENSG00000122729ACO110081.890ENSONIG00000019869aco19981.890Oreochromis_niloticus
ENSG00000122729ACO18190.456ENSOANG00000012132ACO110090.456Ornithorhynchus_anatinus
ENSG00000122729ACO110092.881ENSOCUG00000015960ACO110092.881Oryctolagus_cuniculus
ENSG00000122729ACO19981.757ENSORLG00000020656aco19981.757Oryzias_latipes
ENSG00000122729ACO19981.532ENSORLG00020010991aco19981.532Oryzias_latipes_hni
ENSG00000122729ACO19981.644ENSORLG00015011785aco19981.644Oryzias_latipes_hsok
ENSG00000122729ACO19980.339ENSOMEG00000000660aco19980.339Oryzias_melastigma
ENSG00000122729ACO110094.938ENSOGAG00000010522ACO110094.938Otolemur_garnettii
ENSG00000122729ACO110094.038ENSOARG00000014707ACO19894.038Ovis_aries
ENSG00000122729ACO110099.888ENSPPAG00000033498ACO110099.888Pan_paniscus
ENSG00000122729ACO110093.926ENSPPRG00000009875ACO110093.926Panthera_pardus
ENSG00000122729ACO110093.813ENSPTIG00000016606ACO19893.813Panthera_tigris_altaica
ENSG00000122729ACO110099.888ENSPTRG00000020843ACO110099.888Pan_troglodytes
ENSG00000122729ACO110098.763ENSPANG00000025270ACO110098.763Papio_anubis
ENSG00000122729ACO110080.877ENSPKIG00000023168aco19980.877Paramormyrops_kingsleyae
ENSG00000122729ACO19988.401ENSPSIG00000008030ACO19988.401Pelodiscus_sinensis
ENSG00000122729ACO19982.320ENSPMGG00000020708aco19982.320Periophthalmus_magnuspinnatus
ENSG00000122729ACO110094.151ENSPEMG00000018464Aco110094.151Peromyscus_maniculatus_bairdii
ENSG00000122729ACO110089.764ENSPCIG00000029321ACO110089.764Phascolarctos_cinereus
ENSG00000122729ACO19981.377ENSPFOG00000013405aco19881.807Poecilia_formosa
ENSG00000122729ACO19082.581ENSPLAG00000023422aco19782.581Poecilia_latipinna
ENSG00000122729ACO19082.500ENSPMEG00000011800aco19882.500Poecilia_mexicana
ENSG00000122729ACO19981.194ENSPREG00000021791aco19981.194Poecilia_reticulata
ENSG00000122729ACO110099.100ENSPPYG00000019150ACO19599.100Pongo_abelii
ENSG00000122729ACO17891.509ENSPCAG00000013222ACO19191.509Procavia_capensis
ENSG00000122729ACO18995.190ENSPCOG00000021198ACO110095.190Propithecus_coquereli
ENSG00000122729ACO19687.850ENSPVAG00000002372ACO19987.850Pteropus_vampyrus
ENSG00000122729ACO110081.890ENSPNYG00000009425aco19981.890Pundamilia_nyererei
ENSG00000122729ACO110083.015ENSPNAG00000017918aco110083.015Pygocentrus_nattereri
ENSG00000122729ACO110093.363ENSRNOG00000005849Aco110093.363Rattus_norvegicus
ENSG00000122729ACO110098.425ENSRBIG00000034592ACO110098.425Rhinopithecus_bieti
ENSG00000122729ACO110098.538ENSRROG00000042672ACO110098.538Rhinopithecus_roxellana
ENSG00000122729ACO110097.075ENSSBOG00000026008ACO110097.075Saimiri_boliviensis_boliviensis
ENSG00000122729ACO110090.225ENSSHAG00000008924ACO110090.225Sarcophilus_harrisii
ENSG00000122729ACO19982.864ENSSFOG00015018941aco19982.864Scleropages_formosus
ENSG00000122729ACO17583.284ENSSMAG00000018908aco18083.284Scophthalmus_maximus
ENSG00000122729ACO19982.770ENSSDUG00000002984aco19982.770Seriola_dumerili
ENSG00000122729ACO19982.883ENSSLDG00000013952aco19982.883Seriola_lalandi_dorsalis
ENSG00000122729ACO19690.070ENSSARG00000008437ACO110090.070Sorex_araneus
ENSG00000122729ACO19986.584ENSSPUG00000002916ACO19986.584Sphenodon_punctatus
ENSG00000122729ACO110082.340ENSSPAG00000019147aco19982.340Stegastes_partitus
ENSG00000122729ACO110095.051ENSSSCG00000023807ACO110095.051Sus_scrofa
ENSG00000122729ACO19986.937ENSTGUG00000001505ACO19986.937Taeniopygia_guttata
ENSG00000122729ACO19981.582ENSTRUG00000006888aco19981.695Takifugu_rubripes
ENSG00000122729ACO19979.571ENSTNIG00000005288aco19979.571Tetraodon_nigroviridis
ENSG00000122729ACO110091.114ENSTBEG00000012369ACO110091.114Tupaia_belangeri
ENSG00000122729ACO110094.826ENSTTRG00000016991ACO19994.826Tursiops_truncatus
ENSG00000122729ACO110093.701ENSUAMG00000020699ACO110093.701Ursus_americanus
ENSG00000122729ACO110093.701ENSUMAG00000005807ACO110093.701Ursus_maritimus
ENSG00000122729ACO19694.249ENSVPAG00000009876ACO110094.249Vicugna_pacos
ENSG00000122729ACO110093.251ENSVVUG00000021152ACO19193.251Vulpes_vulpes
ENSG00000122729ACO19985.281ENSXETG00000009184aco19985.281Xenopus_tropicalis
ENSG00000122729ACO15082.086ENSXCOG00000005638aco19682.086Xiphophorus_couchianus
ENSG00000122729ACO19981.419ENSXMAG00000023603aco19981.419Xiphophorus_maculatus
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0003723RNA binding1946430.IDAFunction
GO:0003723RNA binding1903202.NASFunction
GO:0003994aconitate hydratase activity21873635.IBAFunction
GO:0003994aconitate hydratase activity1946430.8041788.IDAFunction
GO:0003994aconitate hydratase activity1281544.IMPFunction
GO:0005515protein binding19762596.19762597.23414517.IPIFunction
GO:0005737cytoplasm1281544.IMPComponent
GO:0005737cytoplasm1738601.NASComponent
GO:0005739mitochondrion21873635.IBAComponent
GO:0005739mitochondrion-IDAComponent
GO:0005783endoplasmic reticulum16144863.IDAComponent
GO:0005794Golgi apparatus16144863.IDAComponent
GO:0005829cytosol21873635.IBAComponent
GO:0005829cytosol16527810.IDAComponent
GO:0005829cytosol-TASComponent
GO:0006099tricarboxylic acid cycle21873635.IBAProcess
GO:0006101citrate metabolic process21873635.IBAProcess
GO:0006101citrate metabolic process8041788.16527810.IDAProcess
GO:0006101citrate metabolic process1281544.IMPProcess
GO:0006417regulation of translation-IEAProcess
GO:0006879cellular iron ion homeostasis-TASProcess
GO:0009791post-embryonic development-IEAProcess
GO:0010040response to iron(II) ion8041788.IDAProcess
GO:0030350iron-responsive element binding8041788.IDAFunction
GO:0030350iron-responsive element binding1281544.23891004.IMPFunction
GO:0046872metal ion binding-IEAFunction
GO:0050892intestinal absorption-IEAProcess
GO:00515383 iron, 4 sulfur cluster binding21873635.IBAFunction
GO:00515383 iron, 4 sulfur cluster binding1281544.IMPFunction
GO:00515394 iron, 4 sulfur cluster binding21873635.IBAFunction
GO:00515394 iron, 4 sulfur cluster binding16407072.IDAFunction
GO:00515394 iron, 4 sulfur cluster binding1281544.IMPFunction
GO:0070062extracellular exosome19056867.23533145.HDAComponent
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