| 28980860 | behavior of proteins involved in amyotrophic lateral sclerosis and frontotemporal lobar degeneration. | Autophagy | 2017 | Uversky VN | doi: 10.1080/15548627.2017.1384889 |
| 27226551 | Developmentally Regulated RNA-binding Protein 1 (Drb1)/RNA-binding Motif Protein 45 (RBM45), a Nuclear-Cytoplasmic Trafficking Protein, Forms TAR DNA-binding Protein 43 (TDP-43)-mediated Cytoplasmic Aggregates. | J Biol Chem | 2016 Jul 15 | Mashiko T | doi: 10.1074/jbc.M115.712232 |
| 27033831 | Mechanisms of FUS mutations in familial amyotrophic lateral sclerosis. | Brain Res | 2016 Sep 15 | Shang Y | doi: 10.1016/j.brainres.2016.03.036 |
| 28090150 | M1 and M2 Functional Imprinting of Primary Microglia: Role of P2X7 Activation and miR-125b. | Mediators Inflamm | 2016 | Parisi C | doi: 10.1155/2016/2989548 |
| 23474849 | RNA dysfunction and aggrephagy at the centre of an amyotrophic lateral sclerosis/frontotemporal dementia disease continuum. | Brain | 2013 May | Thomas M | doi: 10.1093/brain/awt030 |
| 26510133 | Transcriptomic Changes Due to Cytoplasmic TDP-43 Expression Reveal Dysregulation of Histone Transcripts and Nuclear Chromatin. | PLoS One | 2015 Oct 28 | Amlie-Wolf A | doi: 10.1371/journal.pone.0141836 |
| 22028183 | RNA-binding proteins in neurodegenerative disease: TDP-43 and beyond. | Wiley Interdiscip Rev RNA | 2012 Mar-Apr | Hanson KA | doi: 10.1002/wrna.111 |
| 24113842 | TDP-43 regulates the microprocessor complex activity during in vitro neuronal differentiation. | Mol Neurobiol | 2013 Dec | Di Carlo V | doi: 10.1007/s12035-013-8564-x |
| 23975767 | catRAPID omics: a web server for large-scale prediction of protein-RNA interactions. | Bioinformatics | 2013 Nov 15 | Agostini F | doi: 10.1093/bioinformatics/btt495 |
| 23804749 | RNA binding mediates neurotoxicity in the transgenic Drosophila model of TDP-43 proteinopathy. | Hum Mol Genet | 2013 Nov 15 | Ihara R | doi: 10.1093/hmg/ddt296 |
| 28167528 | Heat Shock-induced Phosphorylation of TAR DNA-binding Protein 43 (TDP-43) by MAPK/ERK Kinase Regulates TDP-43 Function. | J Biol Chem | 2017 Mar 24 | Li W | doi: 10.1074/jbc.M116.753913 |
| 26838063 | A molecular mechanism realizing sequence-specific recognition of nucleic acids by TDP-43. | Sci Rep | 2016 Feb 3 | Furukawa Y | doi: 10.1038/srep20576. |
| 26672899 | Analysis of RNA metabolism in peripheral WBCs of TDP-43 KI mice identifies novel biomarkers of ALS. | Neurosci Res | 2016 May | Hasegawa M | doi: 10.1016/j.neures.2015.11.009 |
| 26525917 | MTHFSD and DDX58 are novel RNA-binding proteins abnormally regulated in amyotrophic lateral sclerosis. | Brain | 2016 Jan | MacNair L | doi: 10.1093/brain/awv308 |
| 28600885 | Immunolocalization of TAR DNA-binding protein of 43kDa (TDP-43) in mouse seminiferous epithelium. | Mol Reprod Dev | 2017 Aug | Osuru HP | doi: 10.1002/mrd.22851 |
| 31132467 | Cytoplasmic functions of TDP-43 and FUS and their role in ALS. | Semin Cell Dev Biol | 2019 Jun 4 | Birsa N | doi: 10.1016/j.semcdb.2019.05.023 |
| 31345270 | Mice deficient in the C-terminal domain of TAR DNA-binding protein 43 develop age-dependent motor dysfunction associated with impaired Notch1-Akt signaling pathway. | Acta Neuropathol Commun | 2019 Jul 25 | Nishino K | doi: 10.1186/s40478-019-0776-5. |
| 17481916 | TDP43 is a human low molecular weight neurofilament (hNFL) mRNA-binding protein. | Mol Cell Neurosci | 2007 Jun | Strong MJ | - |
| 22079416 | Neurodegeneration the RNA way. | Prog Neurobiol | 2012 May | Renoux AJ | doi: 10.1016/j.pneurobio.2011.10.006 |
| 23280309 | RNA-mediated toxicity in neurodegenerative disease. | Mol Cell Neurosci | 2013 Sep | Belzil VV | doi: 10.1016/j.mcn.2012.12.006 |
| 21358643 | Long pre-mRNA depletion and RNA missplicing contribute to neuronal vulnerability from loss of TDP-43. | Nat Neurosci | 2011 Apr | Polymenidou M | doi: 10.1038/nn.2779 |
| 20736350 | Altered distributions of Gemini of coiled bodies and mitochondria in motor neurons of TDP-43 transgenic mice. | Proc Natl Acad Sci U S A | 2010 Sep 14 | Shan X | doi: 10.1073/pnas.1003459107 |
| 20660762 | Deletion of TDP-43 down-regulates Tbc1d1, a gene linked to obesity, and alters body fat metabolism. | Proc Natl Acad Sci U S A | 2010 Sep 14 | Chiang PM | doi: 10.1073/pnas.1002176107 |
| 28072389 | Suppression of C9orf72 RNA repeat-induced neurotoxicity by the ALS-associated RNA-binding protein Zfp106. | Elife | 2017 Jan 10 | Celona B | doi: 10.7554/eLife.19032. |
| 26614389 | TDP-43 functions within a network of hnRNP proteins to inhibit the production of a truncated human SORT1 receptor. | Hum Mol Genet | 2016 Feb 1 | Mohagheghi F | doi: 10.1093/hmg/ddv491 |
| 26056265 | Amelioration of toxicity in neuronal models of amyotrophic lateral sclerosis by hUPF1. | Proc Natl Acad Sci U S A | 2015 Jun 23 | Barmada SJ | doi: 10.1073/pnas.1509744112 |
| 29916022 | Mechanisms Associated with TDP-43 Neurotoxicity in ALS/FTLD. | Adv Neurobiol | 2018 | Shenouda M | doi: 10.1007/978-3-319-89689-2_9. |
| 22444279 | Misregulated RNA processing in amyotrophic lateral sclerosis. | Brain Res | 2012 Jun 26 | Polymenidou M | doi: 10.1016/j.brainres.2012.02.059 |
| 24507191 | Axonal transport of TDP-43 mRNA granules is impaired by ALS-causing mutations. | Neuron | 2014 Feb 5 | Alami NH | doi: 10.1016/j.neuron.2013.12.018. |
| 24464995 | The crystal structure of TDP-43 RRM1-DNA complex reveals the specific recognition for UG- and TG-rich nucleic acids. | Nucleic Acids Res | 2014 Apr | Kuo PH | doi: 10.1093/nar/gkt1407 |
| 27838743 | Intrinsic disorder in proteins involved in amyotrophic lateral sclerosis. | Cell Mol Life Sci | 2017 Apr | Santamaria N | doi: 10.1007/s00018-016-2416-6 |
| 18396105 | TARDBP mutations in amyotrophic lateral sclerosis with TDP-43 neuropathology: a genetic and histopathological analysis. | Lancet Neurol | 2008 May | Van Deerlin VM | doi: 10.1016/S1474-4422(08)70071-1 |
| 23118342 | Muscleblind, BSF and TBPH are mislocalized in the muscle sarcomere of a Drosophila myotonic dystrophy model. | Dis Model Mech | 2013 Jan | Llamusi B | doi: 10.1242/dmm.009563 |
| 23041957 | How do the RNA-binding proteins TDP-43 and FUS relate to amyotrophic lateral sclerosis and frontotemporal degeneration, and to each other? | Curr Opin Neurol | 2012 Dec | Baloh RH | doi: 10.1097/WCO.0b013e32835a269b. |
| 22934129 | Widespread binding of FUS along nascent RNA regulates alternative splicing in the brain. | Sci Rep | 2012 | Rogelj B | doi: 10.1038/srep00603 |
| 22127299 | Gains or losses: molecular mechanisms of TDP43-mediated neurodegeneration. | Nat Rev Neurosci | 2011 Nov 30 | Lee EB | doi: 10.1038/nrn3121. |
| 21956718 | Conjoint pathologic cascades mediated by ALS/FTLD-U linked RNA-binding proteins TDP-43 and FUS. | Neurology | 2011 Oct 25 | Ito D | doi: 10.1212/WNL.0b013e3182343365 |
| 21487023 | A Drosophila model of FUS-related neurodegeneration reveals genetic interaction between FUS and TDP-43. | Hum Mol Genet | 2011 Jul 1 | Lanson NA Jr | doi: 10.1093/hmg/ddr150 |
| 21412718 | RNA-binding proteins and RNA metabolism: a new scenario in the pathogenesis of Amyotrophic lateral sclerosis. | Arch Ital Biol | 2011 Mar | Colombrita C | doi: 10.4449/aib.v149i1.1261. |
| 23172908 | Reduction of polyglutamine toxicity by TDP-43, FUS and progranulin in Huntington's disease models. | Hum Mol Genet | 2013 Feb 15 | Tauffenberger A | doi: 10.1093/hmg/dds485 |
| 23196570 | [Conjoint pathological cascades mediated by RNA-binding proteins, TDP-43, FUS and ataxin-2]. | Rinsho Shinkeigaku | 2012 | Ito D | - |
| 20519548 | TDP-43 mediates degeneration in a novel Drosophila model of disease caused by mutations in VCP/p97. | J Neurosci | 2010 Jun 2 | Ritson GP | doi: 10.1523/JNEUROSCI.5894-09.2010. |
| 24920338 | TDP-43 suppresses CGG repeat-induced neurotoxicity through interactions with HnRNP A2/B1. | Hum Mol Genet | 2014 Oct 1 | He F | doi: 10.1093/hmg/ddu216 |
| 24799714 | Drosophila Valosin-Containing Protein is required for dendrite pruning through a regulatory role in mRNA metabolism. | Proc Natl Acad Sci U S A | 2014 May 20 | Rumpf S | doi: 10.1073/pnas.1406898111 |
| 24013423 | Recruitment into stress granules prevents irreversible aggregation of FUS protein mislocalized to the cytoplasm. | Cell Cycle | 2013 Oct 1 | Shelkovnikova TA | doi: 10.4161/cc.26241 |
| 23431168 | Reactive astrocytes secrete lcn2 to promote neuron death. | Proc Natl Acad Sci U S A | 2013 Mar 5 | Bi F | doi: 10.1073/pnas.1218497110 |
| 28265061 | Amyotrophic lateral sclerosis-linked mutations increase the viscosity of liquid-like TDP-43 RNP granules in neurons. | Proc Natl Acad Sci U S A | 2017 Mar 21 | Gopal PP | doi: 10.1073/pnas.1614462114 |
| 27123980 | USP7 and TDP-43: Pleiotropic Regulation of Cryptochrome Protein Stability Paces the Oscillation of the Mammalian Circadian Clock. | PLoS One | 2016 Apr 28 | Hirano A | doi: 10.1371/journal.pone.0154263 |
| 28301478 | Retrotransposon activation contributes to neurodegeneration in a Drosophila TDP-43 model of ALS. | PLoS Genet | 2017 Mar 16 | Krug L | doi: 10.1371/journal.pgen.1006635 |
| 27368346 | Mislocated FUS is sufficient for gain-of-toxic-function amyotrophic lateral sclerosis phenotypes in mice. | Brain | 2016 Sep | Shiihashi G | doi: 10.1093/brain/aww161 |
| 27015757 | Physiological functions and pathobiology of TDP-43 and FUS/TLS proteins. | J Neurochem | 2016 Aug | Ratti A | doi: 10.1111/jnc.13625 |
| 26735904 | ALS-Causing Mutations Significantly Perturb the Self-Assembly and Interaction with Nucleic Acid of the Intrinsically Disordered Prion-Like Domain of TDP-43. | PLoS Biol | 2016 Jan 6 | Lim L | doi: 10.1371/journal.pbio.1002338 |
| 28510586 | Truncation of the TAR DNA-binding protein 43 is not a prerequisite for cytoplasmic relocalization, and is suppressed by caspase inhibition and by introduction of the A90V sequence variant. | PLoS One | 2017 May 16 | Wobst HJ | doi: 10.1371/journal.pone.0177181 |
| 28687523 | TDP-43 in the spectrum of MND-FTLD pathologies. | Mol Cell Neurosci | 2017 Sep | Heyburn L | doi: 10.1016/j.mcn.2017.07.001 |
| 29142232 | TDP-43 misexpression causes defects in dendritic growth. | Sci Rep | 2017 Nov 15 | Herzog JJ | doi: 10.1038/s41598-017-15914-4. |
| 29618024 | A novel long non-coding RNA Myolinc regulates myogenesis through TDP-43 and Filip1. | J Mol Cell Biol | 2018 Apr 1 | Militello G | doi: 10.1093/jmcb/mjy025. |
| 29779213 | Differential toxicity of TAR DNA-binding protein 43 isoforms depends on their submitochondrial localization in neuronal cells. | J Neurochem | 2018 Sep | Salvatori I | doi: 10.1111/jnc.14465 |
| 30367664 | Formation of Toxic Oligomeric Assemblies of RNA-binding Protein: Musashi in Alzheimer's disease. | Acta Neuropathol Commun | 2018 Oct 26 | Sengupta U | doi: 10.1186/s40478-018-0615-0. |
| 30397173 | Deletion of a specific exon in the voltage-gated calcium channel gene cacophony disrupts locomotion in Drosophila larvae. | J Exp Biol | 2019 Jan 1 | Lembke KM | doi: 10.1242/jeb.191106. |
| 30486313 | Perturbations in Traffic: Aberrant Nucleocytoplasmic Transport at the Heart of Neurodegeneration. | Cells | 2018 Nov 26 | Fahrenkrog B | doi: 10.3390/cells7120232. |
| 30520513 | TDP-43 accelerates deadenylation of target mRNAs by recruiting Caf1 deadenylase. | FEBS Lett | 2019 Feb | Fukushima M | doi: 10.1002/1873-3468.13310 |
| 30742696 | TDP-43 proteinopathy in Theiler's murine encephalomyelitis virus infection. | PLoS Pathog | 2019 Feb 11 | Masaki K | doi: 10.1371/journal.ppat.1007574 |
| 30824544 | Detection of TAR DNA-binding protein 43 (TDP-43) oligomers as initial intermediate species during aggregate formation. | J Biol Chem | 2019 Apr 26 | French RL | doi: 10.1074/jbc.RA118.005889 |
| 31042469 | Loss of Nuclear TDP-43 Is Associated with Decondensation of LINE Retrotransposons. | Cell Rep | 2019 Apr 30 | Liu EY | doi: 10.1016/j.celrep.2019.04.003. |
| 31229690 | TDP-43 knockdown causes innate immune activation via protein kinase R in astrocytes. | Neurobiol Dis | 2019 Jun 20:104514 | LaRocca TJ | doi: 10.1016/j.nbd.2019.104514 |
| 31355778 | TDP-43 regulates early-phase insulin secretion via CaV1.2-mediated exocytosis in islets. | J Clin Invest | 2019 Jul 29 | Araki K | doi: 10.1172/JCI124481 |
| 23134510 | Identification of RNA bound to the TDP-43 ribonucleoprotein complex in the adult mouse brain. | Amyotroph Lateral Scler Frontotemporal Degener | 2013 May | Narayanan RK | doi: 10.3109/21678421.2012.734520 |
| 20020773 | Global analysis of TDP-43 interacting proteins reveals strong association with RNA splicing and translation machinery. | J Proteome Res | 2010 Feb 5 | Freibaum BD | doi: 10.1021/pr901076y. |
| 18957508 | Structural determinants of the cellular localization and shuttling of TDP-43. | J Cell Sci | 2008 Nov 15 | Ayala YM | doi: 10.1242/jcs.038950 |
| 22870402 | Comparison of parallel high-throughput RNA sequencing between knockout of TDP-43 and its overexpression reveals primarily nonreciprocal and nonoverlapping gene expression changes in the central nervous system of Drosophila. | G3 (Bethesda) | 2012 Jul | Hazelett DJ | doi: 10.1534/g3.112.002998 |
| 22608070 | Rodent models of TDP-43: recent advances. | Brain Res | 2012 Jun 26 | Tsao W | doi: 10.1016/j.brainres.2012.04.031 |
| 23301088 | RNA-Seq profiling of spinal cord motor neurons from a presymptomatic SOD1 ALS mouse. | PLoS One | 2013 | Bandyopadhyay U | doi: 10.1371/journal.pone.0053575 |
| 22065782 | A yeast functional screen predicts new candidate ALS disease genes. | Proc Natl Acad Sci U S A | 2011 Dec 27 | Couthouis J | doi: 10.1073/pnas.1109434108 |
| 21826788 | Expression of a Musashi-like gene in sexual and asexual development of the colonial chordate Botryllus schlosseri and phylogenetic analysis of the protein group. | J Exp Zool B Mol Dev Evol | 2011 Dec 15 | Gasparini F | doi: 10.1002/jez.b.21431 |
| 21421050 | RNA targets of TDP-43 identified by UV-CLIP are deregulated in ALS. | Mol Cell Neurosci | 2011 Jul | Xiao S | doi: 10.1016/j.mcn.2011.02.013 |
| 21051541 | Identification of neuronal RNA targets of TDP-43-containing ribonucleoprotein complexes. | J Biol Chem | 2011 Jan 14 | Sephton CF | doi: 10.1074/jbc.M110.190884 |
| 20864052 | TDP-43 and FUS in amyotrophic lateral sclerosis and frontotemporal dementia. | Lancet Neurol | 2010 Oct | Mackenzie IR | doi: 10.1016/S1474-4422(10)70195-2. |
| 20349096 | RNA processing pathways in amyotrophic lateral sclerosis. | Neurogenetics | 2010 Jul | van Blitterswijk M | doi: 10.1007/s10048-010-0239-4 |
| 25503099 | [FEBS Open Bio 4 (2014) 1-10]. | FEBS Open Bio | 2014 Nov 22 | Honda D | doi: 10.1016/j.fob.2014.11.007 |
| 25338097 | Presynaptic localization of Smn and hnRNP R in axon terminals of embryonic and postnatal mouse motoneurons. | PLoS One | 2014 Oct 22 | Dombert B | doi: 10.1371/journal.pone.0110846 |
| 24719334 | The RNA-binding protein TDP-43 selectively disrupts microRNA-1/206 incorporation into the RNA-induced silencing complex. | J Biol Chem | 2014 May 16 | King IN | doi: 10.1074/jbc.M114.561902 |
| 24507183 | TDP-43 in ALS: stay on target almost there. | Neuron | 2014 Feb 5 | Jovicic A | doi: 10.1016/j.neuron.2014.01.034. |
| 24319651 | The ALS/FTLD-related RNA-binding proteins TDP-43 and FUS have common downstream RNA targets in cortical neurons. | FEBS Open Bio | 2013 Nov 20 | Honda D | doi: 10.1016/j.fob.2013.11.001 |
| 23471911 | Motor neurons and glia exhibit specific individualized responses to TDP-43 expression in a Drosophila model of amyotrophic lateral sclerosis. | Dis Model Mech | 2013 May | Estes PS | doi: 10.1242/dmm.010710 |
| 23840699 | Kinase Inhibitor Screening Identifies Cyclin-Dependent Kinases and Glycogen Synthase Kinase 3 as Potential Modulators of TDP-43 Cytosolic Accumulation during Cell Stress. | PLoS One | 2013 Jun 26 | Moujalled D | doi: 10.1371/journal.pone.0067433 |
| 27600654 | Pathogenesis of FUS-associated ALS and FTD: insights from rodent models. | Acta Neuropathol Commun | 2016 Sep 6 | Nolan M | doi: 10.1186/s40478-016-0358-8. |
| 27545621 | ALS Mutations Disrupt Phase Separation Mediated by -and-alpha;-Helical Structure in the TDP-43 Low-Complexity C-Terminal Domain. | Structure | 2016 Sep 6 | Conicella AE | doi: 10.1016/j.str.2016.07.007 |
| 27151080 | Gene-specific mitochondria dysfunctions in human TARDBP and C9ORF72 fibroblasts. | Acta Neuropathol Commun | 2016 May 5 | Onesto E | doi: 10.1186/s40478-016-0316-5. |
| 26514432 | From transcriptomic to protein level changes in TDP-43 and FUS loss-of-function cell models. | Biochim Biophys Acta | 2015 Dec | Colombrita C | doi: 10.1016/j.bbagrm.2015.10.015 |
| 26493020 | Replication study of MATR3 in familial and sporadic amyotrophic lateral sclerosis. | Neurobiol Aging | 2016 Jan | Leblond CS | doi: 10.1016/j.neurobiolaging.2015.09.013 |
| 26102026 | A phosphomimetic mutant TDP-43 (S409/410E) induces Drosha instability and cytotoxicity in Neuro 2A cells. | Biochem Biophys Res Commun | 2015 Aug 14 | Kim KY | doi: 10.1016/j.bbrc.2015.06.125 |
| 28384473 | SCA31 Flies Perform in a Balancing Act between RAN Translation and RNA-Binding Proteins. | Neuron | 2017 Apr 5 | Jackson GR | doi: 10.1016/j.neuron.2017.03.030. |
| 28549443 | Quantitative analysis of cryptic splicing associated with TDP-43 depletion. | BMC Med Genomics | 2017 May 26 | Humphrey J | doi: 10.1186/s12920-017-0274-1. |
| 28663553 | Functional and dynamic polymerization of the ALS-linked protein TDP-43 antagonizes its pathologic aggregation. | Nat Commun | 2017 Jun 29 | Afroz T | doi: 10.1038/s41467-017-00062-0. |
| 28705014 | Mutation in the RRM2 domain of TDP-43 in Amyotrophic Lateral Sclerosis with rapid progression associated with ubiquitin positive aggregates in cultured motor neurons. | Amyotroph Lateral Scler Frontotemporal Degener | 2018 Feb | Maurel C | doi: 10.1080/21678421.2017.1349152 |
| 28854702 | Splicing factors act as genetic modulators of TDP-43 production in a new autoregulatory TDP-43 Drosophila model. | Hum Mol Genet | 2017 Sep 1 | Pons M | doi: 10.1093/hmg/ddx229. |
| 28860970 | Failure to Deliver and Translate-New Insights into RNA Dysregulation in ALS. | Front Cell Neurosci | 2017 Aug 17 | Coyne AN | doi: 10.3389/fncel.2017.00243 |
| 29097807 | TDP-43 accelerates age-dependent degeneration of interneurons. | Sci Rep | 2017 Nov 2 | Tsuiji H | doi: 10.1038/s41598-017-14966-w. |
| 29395044 | TDP43 and RNA instability in amyotrophic lateral sclerosis. | Brain Res | 2018 Aug 15 | Weskamp K | doi: 10.1016/j.brainres.2018.01.015 |
| 29728455 | Microtubules as platforms for probing liquid-liquid phase separation in cells - application to RNA-binding proteins. | J Cell Sci | 2018 Jun 11 | Maucuer A | doi: 10.1242/jcs.214692. |
| 30643292 | ALS-implicated protein TDP-43 sustains levels of STMN2, a mediator of motor neuron growth and repair. | Nat Neurosci | 2019 Feb | Klim JR | doi: 10.1038/s41593-018-0300-4 |
| 30742796 | RNA as a key factor in driving or preventing self-assembly of the TAR DNA-binding protein 43. | J Mol Biol | 2019 Apr 5 | Zacco E | doi: 10.1016/j.jmb.2019.01.028 |
| 31018129 | An Intramolecular Salt Bridge Linking TDP43 RNA Binding, Protein Stability, and TDP43-Dependent Neurodegeneration. | Cell Rep | 2019 Apr 23 | Flores BN | doi: 10.1016/j.celrep.2019.03.093. |
| 31068973 | Suppression of Conditional TDP-43 Transgene Expression Differentially Affects Early Cognitive and Social Phenotypes in TDP-43 Mice. | Front Genet | 2019 Apr 24 | Silva PR | doi: 10.3389/fgene.2019.00369 |
| 31262091 | NMR Fragment-Based Screening against Tandem RNA Recognition Motifs of TDP-43. | Int J Mol Sci | 2019 Jun 30 | Nshogoza G | doi: 10.3390/ijms20133230. |
| 31272829 | Small-Molecule Modulation of TDP-43 Recruitment to Stress Granules Prevents Persistent TDP-43 Accumulation in ALS/FTD. | Neuron | 2019 Jun 18 | Fang MY | doi: 10.1016/j.neuron.2019.05.048 |
| 19965769 | Antagonistic factors control the unproductive splicing of SC35 terminal intron. | Nucleic Acids Res | 2010 Mar | Dreumont N | doi: 10.1093/nar/gkp1086 |
| 22872699 | High-content RNAi screening identifies the Type 1 inositol triphosphate receptor as a modifier of TDP-43 localization and neurotoxicity. | Hum Mol Genet | 2012 Nov 15 | Kim SH | doi: 10.1093/hmg/dds321 |
| 22674575 | Cdc37/Hsp90 protein complex disruption triggers an autophagic clearance cascade for TDP-43 protein. | J Biol Chem | 2012 Jul 13 | Jinwal UK | doi: 10.1074/jbc.M112.367268 |
| 21358640 | Characterizing the RNA targets and position-dependent splicing regulation by TDP-43. | Nat Neurosci | 2011 Apr | Tollervey JR | doi: 10.1038/nn.2778 |
| 21131904 | TDP-43 regulates its mRNA levels through a negative feedback loop. | EMBO J | 2011 Jan 19 | Ayala YM | doi: 10.1038/emboj.2010.310 |
| 20720006 | Amyotrophic lateral sclerosis-associated proteins TDP-43 and FUS/TLS function in a common biochemical complex to co-regulate HDAC6 mRNA. | J Biol Chem | 2010 Oct 29 | Kim SH | doi: 10.1074/jbc.M110.154831 |
| 20624952 | ALS-associated mutations in TDP-43 increase its stability and promote TDP-43 complexes with FUS/TLS. | Proc Natl Acad Sci U S A | 2010 Jul 27 | Ling SC | doi: 10.1073/pnas.1008227107 |
| 25256353 | Activation of AMP-activated protein kinase -and-alpha;1 mediates mislocalization of TDP-43 in amyotrophic lateral sclerosis. | Hum Mol Genet | 2015 Feb 1 | Liu YJ | doi: 10.1093/hmg/ddu497 |
| 24647938 | ALS-linked mutations enlarge TDP-43-enriched neuronal RNA granules in the dendritic arbor. | J Neurosci | 2014 Mar 19 | Liu-Yesucevitz L | doi: 10.1523/JNEUROSCI.2350-13.2014. |
| 24649927 | Targeting TDP-43 in neurodegenerative diseases. | Expert Opin Ther Targets | 2014 Jun | Budini M | doi: 10.1517/14728222.2014.896905 |
| 27632209 | Mutation Frequency of the Major Frontotemporal Dementia Genes, MAPT, GRN and C9ORF72 in a Turkish Cohort of Dementia Patients. | PLoS One | 2016 Sep 15 | Guven G | doi: 10.1371/journal.pone.0162592 |
| 23962724 | Prion-like nuclear aggregation of TDP-43 during heat shock is regulated by HSP40/70 chaperones. | Hum Mol Genet | 2014 Jan 1 | Udan-Johns M | doi: 10.1093/hmg/ddt408 |
| 23835137 | The long non-coding RNA nuclear-enriched abundant transcript 1_2 induces paraspeckle formation in the motor neuron during the early phase of amyotrophic lateral sclerosis. | Mol Brain | 2013 Jul 8 | Nishimoto Y | doi: 10.1186/1756-6606-6-31. |
| 23644307 | Protein aggregates and regional disease spread in ALS is reminiscent of prion-like pathogenesis. | Neurol India | 2013 Mar-Apr | Verma A | doi: 10.4103/0028-3886.111109. |
| 26518462 | An age-related reduction of brain TBPH/TDP-43 levels precedes the onset of locomotion defects in a Drosophila ALS model. | Neuroscience | 2015 Dec 17 | Cragnaz L | doi: 10.1016/j.neuroscience.2015.10.037 |
| 28278534 | Transcription and Splicing Factor TDP-43: Role in Regulation of Gene Expression in Testis. | Semin Reprod Med | 2017 Mar | Reddi PP | doi: 10.1055/s-0037-1599088 |
| 25987361 | An optimized InCell Western screening technique identifies hexachlorophene as a novel potent TDP43 targeting drug. | J Biotechnol | 2015 Aug 10 | Narayan M | doi: 10.1016/j.jbiotec.2015.04.012 |
| 30087231 | Disruption by SaCas9 Endonuclease of HERV-Kenv, a Retroviral Gene with Oncogenic and Neuropathogenic Potential, Inhibits Molecules Involved in Cancer and Amyotrophic Lateral Sclerosis. | Viruses | 2018 Aug 7 | Ibba G | doi: 10.3390/v10080412. |
| 30541625 | Identification of TCERG1 as a new genetic modulator of TDP-43 production in Drosophila. | Acta Neuropathol Commun | 2018 Dec 12 | Pons M | doi: 10.1186/s40478-018-0639-5. |
| 11470789 | Characterization and functional implications of the RNA binding properties of nuclear factor TDP-43, a novel splicing regulator of CFTR exon 9. | J Biol Chem | 2001 Sep 28 | Buratti E | - |
| 14667816 | Structural diversity and functional implications of the eukaryotic TDP gene family. | Genomics | 2004 Jan | Wang HY | - |
| 20133711 | TDP-43 transgenic mice develop spastic paralysis and neuronal inclusions characteristic of ALS and frontotemporal lobar degeneration. | Proc Natl Acad Sci U S A | 2010 Feb 23 | Wils H | doi: 10.1073/pnas.0912417107 |
| 20040602 | TDP-43 is a developmentally regulated protein essential for early embryonic development. | J Biol Chem | 2010 Feb 26 | Sephton CF | doi: 10.1074/jbc.M109.061846 |
| 23104007 | Inhibition of RNA lariat debranching enzyme suppresses TDP-43 toxicity in ALS disease models. | Nat Genet | 2012 Dec | Armakola M | doi: 10.1038/ng.2434 |
| 19864664 | A novel TARDBP mutation in an Australian amyotrophic lateral sclerosis kindred. | J Neurol Neurosurg Psychiatry | 2009 Nov | Williams KL | doi: 10.1136/jnnp.2008.163261. |
| 19808791 | Mutations in TDP-43 link glycine-rich domain functions to amyotrophic lateral sclerosis. | Hum Mol Genet | 2009 Oct 15 | Pesiridis GS | doi: 10.1093/hmg/ddp303. |
| 19833869 | TDP-43 mutant transgenic mice develop features of ALS and frontotemporal lobar degeneration. | Proc Natl Acad Sci U S A | 2009 Nov 3 | Wegorzewska I | doi: 10.1073/pnas.0908767106 |
| 19781077 | Frontotemporal dementia and amyotrophic lateral sclerosis-associated disease protein TDP-43 promotes dendritic branching. | Mol Brain | 2009 Sep 25 | Lu Y | doi: 10.1186/1756-6606-2-30. |
| 23042786 | The FTD/ALS-associated RNA-binding protein TDP-43 regulates the robustness of neuronal specification through microRNA-9a in Drosophila. | Hum Mol Genet | 2013 Jan 15 | Li Z | doi: 10.1093/hmg/dds420 |
| 23048034 | Roles of ataxin-2 in pathological cascades mediated by TAR DNA-binding protein 43 (TDP-43) and Fused in Sarcoma (FUS). | J Biol Chem | 2012 Nov 30 | Nihei Y | doi: 10.1074/jbc.M112.398099 |
| 23060966 | Synaptic activity regulated mRNA-silencing foci for the fine tuning of local protein synthesis at the synapse. | Commun Integr Biol | 2012 Jul 1 | Pascual ML | doi: 10.4161/cib.20257. |
| 19303844 | Rethinking ALS: the FUS about TDP-43. | Cell | 2009 Mar 20 | Lagier-Tourenne C | doi: 10.1016/j.cell.2009.03.006. |
| 19174564 | Structural insights into TDP-43 in nucleic-acid binding and domain interactions. | Nucleic Acids Res | 2009 Apr | Kuo PH | doi: 10.1093/nar/gkp013 |
| 22993125 | The RNA-binding motif 45 (RBM45) protein accumulates in inclusion bodies in amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration with TDP-43 inclusions (FTLD-TDP) patients. | Acta Neuropathol | 2012 Nov | Collins M | doi: 10.1007/s00401-012-1045-x |
| 18703504 | TDP-43 overexpression enhances exon 7 inclusion during the survival of motor neuron pre-mRNA splicing. | J Biol Chem | 2008 Oct 24 | Bose JK | doi: 10.1074/jbc.M805376200 |
| 22932872 | Autophagy activators rescue and alleviate pathogenesis of a mouse model with proteinopathies of the TAR DNA-binding protein 43. | Proc Natl Acad Sci U S A | 2012 Sep 11 | Wang IF | doi: 10.1073/pnas.1206362109 |
| 18223198 | Variations in the progranulin gene affect global gene expression in frontotemporal lobar degeneration. | Hum Mol Genet | 2008 May 15 | Chen-Plotkin AS | doi: 10.1093/hmg/ddn023 |
| 18088371 | TDP-43, the signature protein of FTLD-U, is a neuronal activity-responsive factor. | J Neurochem | 2008 May | Wang IF | - |
| 22900096 | Alteration of POLDIP3 splicing associated with loss of function of TDP-43 in tissues affected with ALS. | PLoS One | 2012 | Shiga A | doi: 10.1371/journal.pone.0043120 |
| 22848727 | Methylene blue protects against TDP-43 and FUS neuronal toxicity in C. elegans and D. rerio. | PLoS One | 2012 | Vaccaro A | doi: 10.1371/journal.pone.0042117 |
| 22855830 | Autoregulation of TDP-43 mRNA levels involves interplay between transcription, splicing, and alternative polyA site selection. | Genes Dev | 2012 Aug 1 | Avendano-Vazquez SE | doi: 10.1101/gad.194829.112. |
| 22835933 | The N-terminus of TDP-43 promotes its oligomerization and enhances DNA binding affinity. | Biochem Biophys Res Commun | 2012 Aug 24 | Chang CK | doi: 10.1016/j.bbrc.2012.07.071 |
| 22792076 | TDP-1/TDP-43 regulates stress signaling and age-dependent proteotoxicity in Caenorhabditis elegans. | PLoS Genet | 2012 Jul | Vaccaro A | doi: 10.1371/journal.pgen.1002806 |
| 22761693 | Coaggregation of RNA-binding proteins in a model of TDP-43 proteinopathy with selective RGG motif methylation and a role for RRM1 ubiquitination. | PLoS One | 2012 | Dammer EB | doi: 10.1371/journal.pone.0038658 |
| 22764223 | ALS-associated ataxin 2 polyQ expansions enhance stress-induced caspase 3 activation and increase TDP-43 pathological modifications. | J Neurosci | 2012 Jul 4 | Hart MP | doi: 10.1523/JNEUROSCI.0996-12.2012. |
| 22641816 | The ALS disease protein TDP-43 is actively transported in motor neuron axons and regulates axon outgrowth. | Hum Mol Genet | 2012 Aug 15 | Fallini C | doi: 10.1093/hmg/dds205 |
| 22454397 | Evaluating the role of the FUS/TLS-related gene EWSR1 in amyotrophic lateral sclerosis. | Hum Mol Genet | 2012 Jul 1 | Couthouis J | doi: 10.1093/hmg/dds116 |
| 22427648 | TDP-43 and FUS RNA-binding proteins bind distinct sets of cytoplasmic messenger RNAs and differently regulate their post-transcriptional fate in motoneuron-like cells. | J Biol Chem | 2012 May 4 | Colombrita C | doi: 10.1074/jbc.M111.333450 |
| 22405725 | TDP-43 aggregation in neurodegeneration: are stress granules the key? | Brain Res | 2012 Jun 26 | Dewey CM | doi: 10.1016/j.brainres.2012.02.032 |
| 22416763 | Quantitative analysis of the detergent-insoluble brain proteome in frontotemporal lobar degeneration using SILAC internal standards. | J Proteome Res | 2012 May 4 | Seyfried NT | doi: 10.1021/pr2010814 |
| 22363618 | Mutant TDP-43 and FUS cause age-dependent paralysis and neurodegeneration in C. elegans. | PLoS One | 2012 | Vaccaro A | doi: 10.1371/journal.pone.0031321 |
| 22327514 | Common variants near TARDBP and EGR2 are associated with susceptibility to Ewing sarcoma. | Nat Genet | 2012 Feb 12 | Postel-Vinay S | doi: 10.1038/ng.1085. |
| 22052911 | Regulation of autophagy by neuropathological protein TDP-43. | J Biol Chem | 2011 Dec 30 | Bose JK | doi: 10.1074/jbc.M111.237115 |
| 21878116 | TDP-43 knockdown impairs neurite outgrowth dependent on its target histone deacetylase 6. | Mol Neurodegener | 2011 Aug 30 | Fiesel FC | doi: 10.1186/1750-1326-6-64. |
| 21847013 | RNA-binding proteins with prion-like domains in ALS and FTLD-U. | Prion | 2011 Jul-Sep | Gitler AD | doi: 10.4161/pri.5.3.17230 |
| 21813273 | Understanding the role of TDP-43 and FUS/TLS in ALS and beyond. | Curr Opin Neurobiol | 2011 Dec | Da Cruz S | doi: 10.1016/j.conb.2011.05.029 |
| 21829392 | FUS and TARDBP but not SOD1 interact in genetic models of amyotrophic lateral sclerosis. | PLoS Genet | 2011 Aug | Kabashi E | doi: 10.1371/journal.pgen.1002214 |
| 21777389 | TDP-43 and FUS/TLS: cellular functions and implications for neurodegeneration. | FEBS J | 2011 Oct | Fiesel FC | doi: 10.1111/j.1742-4658.2011.08258.x |
| 21673800 | Neuronal function and dysfunction of Drosophila dTDP. | PLoS One | 2011 | Lin MJ | doi: 10.1371/journal.pone.0020371 |
| 21626001 | [Motor neuron diseases]. | Nervenarzt | 2011 Jun | Petri S | doi: 10.1007/s00115-010-2967-y. |
| 21540991 | State of the art and the dark side of amyotrophic lateral sclerosis. | World J Biol Chem | 2010 May 26 | Musaro A | doi: 10.4331/wjbc.v1.i5.62. |
| 21541367 | Molecular determinants and genetic modifiers of aggregation and toxicity for the ALS disease protein FUS/TLS. | PLoS Biol | 2011 Apr | Sun Z | doi: 10.1371/journal.pbio.1000614 |
| 21441568 | Wild-type and A315T mutant TDP-43 exert differential neurotoxicity in a Drosophila model of ALS. | Hum Mol Genet | 2011 Jun 15 | Estes PS | doi: 10.1093/hmg/ddr124 |
| 21452073 | FUS/TLS forms cytoplasmic aggregates, inhibits cell growth and interacts with TDP-43 in a yeast model of amyotrophic lateral sclerosis. | Protein Cell | 2011 Mar | Kryndushkin D | doi: 10.1007/s13238-011-1525-0 |
| 21412434 | TDP-43 regulates Drosophila neuromuscular junctions growth by modulating Futsch/MAP1B levels and synaptic microtubules organization. | PLoS One | 2011 Mar 11 | Godena VK | doi: 10.1371/journal.pone.0017808. |
| 21252238 | TDP-43 is a transcriptional repressor: the testis-specific mouse acrv1 gene is a TDP-43 target in vivo. | J Biol Chem | 2011 Apr 1 | Lalmansingh AS | doi: 10.1074/jbc.M110.166587 |
| 21135580 | Implications of the prion-related Q/N domains in TDP-43 and FUS. | Prion | 2011 Jan-Mar | Udan M | - |
| 21124004 | TDP-43-based animal models of neurodegeneration: new insights into ALS pathology and pathophysiology. | Neurodegener Dis | 2011 | Wegorzewska I | doi: 10.1159/000321547 |
| 21031599 | PRO-MINE: A bioinformatics repository and analytical tool for TARDBP mutations. | Hum Mutat | 2011 Jan | Pinto S | doi: 10.1002/humu.21393. |
| 23200923 | The RRM domain of human fused in sarcoma protein reveals a non-canonical nucleic acid binding site. | Biochim Biophys Acta | 2013 Feb | Liu X | doi: 10.1016/j.bbadis.2012.11.012 |
| 20806063 | TDP-43-mediated neuron loss in vivo requires RNA-binding activity. | PLoS One | 2010 Aug 18 | Voigt A | doi: 10.1371/journal.pone.0012247. |
| 20660618 | Elevated expression of TDP-43 in the forebrain of mice is sufficient to cause neurological and pathological phenotypes mimicking FTLD-U. | J Exp Med | 2010 Aug 2 | Tsai KJ | doi: 10.1084/jem.20092164 |
| 20530643 | Neurotoxic effects of TDP-43 overexpression in C. elegans. | Hum Mol Genet | 2010 Aug 15 | Ash PE | doi: 10.1093/hmg/ddq230 |
| 20406182 | Protein aggregation and defective RNA metabolism as mechanisms for motor neuron damage. | CNS Neurol Disord Drug Targets | 2010 Jul | Ticozzi N | - |
| 20356930 | Prion-like disorders: blurring the divide between transmissibility and infectivity. | J Cell Sci | 2010 Apr 15 | Cushman M | doi: 10.1242/jcs.051672. |
| 25602706 | TDP-43 regulates -and-beta;-adducin (Add2) transcript stability. | RNA Biol | 2014 | Costessi L | doi: 10.1080/15476286.2014.996081. |
| 25556531 | An acetylation switch controls TDP-43 function and aggregation propensity. | Nat Commun | 2015 Jan 5 | Cohen TJ | doi: 10.1038/ncomms6845. |
| 25429138 | Futsch/MAP1B mRNA is a translational target of TDP-43 and is neuroprotective in a Drosophila model of amyotrophic lateral sclerosis. | J Neurosci | 2014 Nov 26 | Coyne AN | doi: 10.1523/JNEUROSCI.2526-14.2014. |
| 25442115 | Functional complementation in Drosophila to predict the pathogenicity of TARDBP variants: evidence for a loss-of-function mechanism. | Neurobiol Aging | 2015 Feb | Vanden Broeck L | doi: 10.1016/j.neurobiolaging.2014.09.001 |
| 25391662 | TDP-1, the Caenorhabditis elegans ortholog of TDP-43, limits the accumulation of double-stranded RNA. | EMBO J | 2014 Dec 17 | Saldi TK | doi: 10.15252/embj.201488740 |
| 25375143 | Analysis of nuclear export sequence regions of FUS-Related RNA-binding proteins in essential tremor. | PLoS One | 2014 Nov 6 | Lorenzo-Betancor O | doi: 10.1371/journal.pone.0111989 |
| 25155018 | Early retinal neurodegeneration and impaired Ran-mediated nuclear import of TDP-43 in progranulin-deficient FTLD. | J Exp Med | 2014 Sep 22 | Ward ME | doi: 10.1084/jem.20140214 |
| 25158920 | Genetic analysis of matrin 3 gene in French amyotrophic lateral sclerosis patients and frontotemporal lobar degeneration with amyotrophic lateral sclerosis patients. | Neurobiol Aging | 2014 Dec | Millecamps S | doi: 10.1016/j.neurobiolaging.2014.07.016 |
| 25002991 | Yeast genetic screen reveals novel therapeutic strategy for ALS. | Rare Dis | 2013 Mar 27 | Figley MD | doi: 10.4161/rdis.24420 |
| 24981865 | HDAC6 is a Bruchpilot deacetylase that facilitates neurotransmitter release. | Cell Rep | 2014 Jul 10 | Miskiewicz K | doi: 10.1016/j.celrep.2014.05.051 |
| 24926617 | p53-directed translational control can shape and expand the universe of p53 target genes. | Cell Death Differ | 2014 Oct | Zaccara S | doi: 10.1038/cdd.2014.79 |
| 24785678 | Curcumin abolishes mutant TDP-43 induced excitability in a motoneuron-like cellular model of ALS. | Neuroscience | 2014 Jul 11 | Dong H | doi: 10.1016/j.neuroscience.2014.04.032 |
| 24686783 | Mutations in the Matrin 3 gene cause familial amyotrophic lateral sclerosis. | Nat Neurosci | 2014 May | Johnson JO | doi: 10.1038/nn.3688 |
| 24658850 | RNA-binding proteins in neurological diseases. | Sci China Life Sci | 2014 Apr | Zhou H | - |
| 24363135 | Progressive hemiparesis (Mills syndrome) with aphasia in amyotrophic lateral sclerosis. | Neurology | 2014 Feb 4 | Baumer D | doi: 10.1212/WNL.0000000000000090 |
| 24275199 | Motor neuron expression of the voltage-gated calcium channel cacophony restores locomotion defects in a Drosophila, TDP-43 loss of function model of ALS. | Brain Res | 2014 Oct 10 | Chang JC | doi: 10.1016/j.brainres.2013.11.019 |
| 24240615 | Molecular basis of UG-rich RNA recognition by the human splicing factor TDP-43. | Nat Struct Mol Biol | 2013 Dec | Lukavsky PJ | doi: 10.1038/nsmb.2698 |
| 24256250 | The role of TDP-43 in the pathogenesis of ALS and FTLD. | Biochem Soc Trans | 2013 Dec | Baralle M | doi: 10.1042/BST20130186. |
| 24262168 | Investigating FUS variation in Parkinson's disease. | Parkinsonism Relat Disord | 2014 Jan | Labbe C | doi: 10.1016/S1353-8020(13)70035-X. |
| 24085347 | Amyotrophic lateral sclerosis: an update on recent genetic insights. | J Neurol | 2013 Nov | Iguchi Y | doi: 10.1007/s00415-013-7112-y |
| 24090760 | The clinical and pathological phenotypes of frontotemporal dementia with C9ORF72 mutations. | J Neurol Sci | 2013 Dec 15 | Liu Y | doi: 10.1016/j.jns.2013.09.013 |
| 24019256 | A high-content screen identifies novel compounds that inhibit stress-induced TDP-43 cellular aggregation and associated cytotoxicity. | J Biomol Screen | 2014 Jan | Boyd JD | doi: 10.1177/1087057113501553 |
| 23967244 | TDP-43, an ALS linked protein, regulates fat deposition and glucose homeostasis. | PLoS One | 2013 Aug 13 | Stallings NR | doi: 10.1371/journal.pone.0071793 |
| 23840565 | RNP2 of RNA recognition motif 1 plays a central role in the aberrant modification of TDP-43. | PLoS One | 2013 Jun 28 | Takagi S | doi: 10.1371/journal.pone.0066966 |
| 23721326 | Similar dose-dependence of motor neuron cell death caused by wild type human TDP-43 and mutants with ALS-associated amino acid substitutions. | J Biomed Sci | 2013 May 30 | Wu LS | doi: 10.1186/1423-0127-20-33. |
| 23737961 | Inhibition of TDP-43 aggregation by nucleic acid binding. | PLoS One | 2013 May 30 | Huang YC | doi: 10.1371/journal.pone.0064002 |
| 23629963 | Stress granules as crucibles of ALS pathogenesis. | J Cell Biol | 2013 Apr 29 | Li YR | doi: 10.1083/jcb.201302044. |
| 23587065 | Stress granules in neurodegeneration--lessons learnt from TAR DNA binding protein of 43 kDa and fused in sarcoma. | FEBS J | 2013 Sep | Bentmann E | doi: 10.1111/febs.12287 |
| 23468938 | Identification of genetic modifiers of TDP-43 neurotoxicity in Drosophila. | PLoS One | 2013 | Zhan L | doi: 10.1371/journal.pone.0057214 |
| 28343865 | Regulatory Role of RNA Chaperone TDP-43 for RNA Misfolding and Repeat-Associated Translation in SCA31. | Neuron | 2017 Apr 5 | Ishiguro T | doi: 10.1016/j.neuron.2017.02.046 |
| 25239623 | Hu antigen R (HuR) is a positive regulator of the RNA-binding proteins TDP-43 and FUS/TLS: implications for amyotrophic lateral sclerosis. | J Biol Chem | 2014 Nov 14 | Lu L | doi: 10.1074/jbc.M114.573246 |
| 26507309 | Lack of association between TDP-43 pathology and tau mis-splicing in Alzheimer's disease. | Neurobiol Aging | 2016 Jan | Niblock M | doi: 10.1016/j.neurobiolaging.2015.09.022 |
| 28334913 | TDP-43 mutations causing amyotrophic lateral sclerosis are associated with altered expression of RNA-binding protein hnRNP K and affect the Nrf2 antioxidant pathway. | Hum Mol Genet | 2017 May 1 | Moujalled D | doi: 10.1093/hmg/ddx093. |
| 27999880 | [Pathomechanisms and clinical aspects of frontotemporal lobar degeneration]. | Nervenarzt | 2017 Feb | Burger K | doi: 10.1007/s00115-016-0259-x. |
| 26883171 | Structural analysis of disease-related TDP-43 D169G mutation: linking enhanced stability and caspase cleavage efficiency to protein accumulation. | Sci Rep | 2016 Feb 17 | Chiang CH | doi: 10.1038/srep21581. |
| 27030292 | Two mutations G335D and Q343R within the amyloidogenic core region of TDP-43 influence its aggregation and inclusion formation. | Sci Rep | 2016 Mar 31 | Jiang LL | doi: 10.1038/srep23928. |
| 26757674 | Interaction of RNA with a C-terminal fragment of the amyotrophic lateral sclerosis-associated TDP43 reduces cytotoxicity. | Sci Rep | 2016 Jan 13 | Kitamura A | doi: 10.1038/srep19230. |
| 26728149 | Pur-alpha regulates cytoplasmic stress granule dynamics and ameliorates FUS toxicity. | Acta Neuropathol | 2016 Apr | Daigle JG | doi: 10.1007/s00401-015-1530-0 |
| 26891106 | Huntington's Disease Protein Huntingtin Associates with its own mRNA. | J Huntingtons Dis | 2016 | Culver BP | doi: 10.3233/JHD-150177. |
| 27681424 | PTBP1 and PTBP2 Repress Nonconserved Cryptic Exons. | Cell Rep | 2016 Sep 27 | Ling JP | doi: 10.1016/j.celrep.2016.08.071. |
| 27465358 | Lentiviral vector-mediated overexpression of mutant ataxin-7 recapitulates SCA7 pathology and promotes accumulation of the FUS/TLS and MBNL1 RNA-binding proteins. | Mol Neurodegener | 2016 Jul 28 | Alves S | doi: 10.1186/s13024-016-0123-2. |
| 27317832 | Structural insights into the multi-determinant aggregation of TDP-43 in motor neuron-like cells. | Neurobiol Dis | 2016 Oct | Bozzo F | doi: 10.1016/j.nbd.2016.06.006 |
| 26938019 | Altered mRNP granule dynamics in FTLD pathogenesis. | J Neurochem | 2016 Aug | Bowden HA | doi: 10.1111/jnc.13601 |
| 26902497 | TBPH/TDP-43 modulates translation of Drosophila futsch mRNA through an UG-rich sequence within its 5'UTR. | Brain Res | 2016 Sep 15 | Romano M | doi: 10.1016/j.brainres.2016.02.022 |
| 26293199 | Distinct partitioning of ALS associated TDP-43, FUS and SOD1 mutants into cellular inclusions. | Sci Rep | 2015 Aug 21 | Farrawell NE | doi: 10.1038/srep13416. |
| 26250685 | TDP-43 repression of nonconserved cryptic exons is compromised in ALS-FTD. | Science | 2015 Aug 7 | Ling JP | doi: 10.1126/science.aab0983. |
| 26220395 | Long noncoding RNAs in TDP-43 and FUS/TLS-related frontotemporal lobar degeneration (FTLD). | Neurobiol Dis | 2015 Oct | Lourenco GF | doi: 10.1016/j.nbd.2015.07.011 |
| 26160665 | The prion-like RNA-processing protein HNRPDL forms inherently toxic amyloid-like inclusion bodies in bacteria. | Microb Cell Fact | 2015 Jul 11 | Navarro S | doi: 10.1186/s12934-015-0284-7. |
| 26099433 | TDP-35 sequesters TDP-43 into cytoplasmic inclusions through binding with RNA. | FEBS Lett | 2015 Jul 8 | Che MX | doi: 10.1016/j.febslet.2015.06.009 |
| 24870760 | Staurosporine induced apoptosis rapidly downregulates TDP- 43 in glioma cells. | Asian Pac J Cancer Prev | 2014 | Nan YN | - |
| 26047658 | The function of RNA-binding proteins at the synapse: implications for neurodegeneration. | Cell Mol Life Sci | 2015 Oct | Sephton CF | doi: 10.1007/s00018-015-1943-x |
| 28405022 | Therapeutic reduction of ataxin-2 extends lifespan and reduces pathology in TDP-43 mice. | Nature | 2017 Apr 20 | Becker LA | doi: 10.1038/nature22038 |
| 27810362 | Imbalance of mitochondrial dynamics in Drosophila models of amyotrophic lateral sclerosis. | Biochem Biophys Res Commun | 2016 Dec 9 | Altanbyek V | doi: 10.1016/j.bbrc.2016.10.134 |
| 28622300 | The ALS-linked E102Q mutation in Sigma receptor-1 leads to ER stress-mediated defects in protein homeostasis and dysregulation of RNA-binding proteins. | Cell Death Differ | 2017 Oct | Dreser A | doi: 10.1038/cdd.2017.88 |
| 28669544 | TDP-43 Depletion in Microglia Promotes Amyloid Clearance but Also Induces Synapse Loss. | Neuron | 2017 Jul 19 | Paolicelli RC | doi: 10.1016/j.neuron.2017.05.037 |
| 28831750 | Imbalanced expression of polycistronic miRNA in acute myeloid leukemia. | Int J Hematol | 2017 Dec | Kotaki R | doi: 10.1007/s12185-017-2314-1 |
| 27150074 | Oxidative stress and mitochondrial damage in the pathogenesis of ALS: New perspectives. | Neurosci Lett | 2017 Jan 1 | Bozzo F | doi: 10.1016/j.neulet.2016.04.065 |
| 28837687 | The spliceosome-associated protein Mfap1 binds to VCP in Drosophila. | PLoS One | 2017 Aug 24 | Rode S | doi: 10.1371/journal.pone.0183733 |
| 28847811 | Restoration of Motor Defects Caused by Loss of Drosophila TDP-43 by Expression of the Voltage-Gated Calcium Channel, Cacophony, in Central Neurons. | J Neurosci | 2017 Sep 27 | Lembke KM | doi: 10.1523/JNEUROSCI.0554-17.2017 |
| 27871485 | Unusual Processing Generates SPA LncRNAs that Sequester Multiple RNA Binding Proteins. | Mol Cell | 2016 Nov 3 | Wu H | doi: 10.1016/j.molcel.2016.10.007 |
| 28969660 | Novel miR-b2122 regulates several ALS-related RNA-binding proteins. | Mol Brain | 2017 Oct 2 | Hawley ZCE | doi: 10.1186/s13041-017-0326-7. |
| 28978466 | Post-transcriptional Inhibition of Hsc70-4/HSPA8 Expression Leads to Synaptic Vesicle Cycling Defects in Multiple Models of ALS. | Cell Rep | 2017 Oct 3 | Coyne AN | doi: 10.1016/j.celrep.2017.09.028. |
| 29070802 | Split GFP technologies to structurally characterize and quantify functional biomolecular interactions of FTD-related proteins. | Sci Rep | 2017 Oct 25 | Foglieni C | doi: 10.1038/s41598-017-14459-w. |
| 28062558 | Biological Spectrum of Amyotrophic Lateral Sclerosis Prions. | Cold Spring Harb Perspect Med | 2017 Nov 1 | Polymenidou M | doi: 10.1101/cshperspect.a024133. |
| 29162978 | Exploring the Interaction of Drosophila TDP-43 and the Type II Voltage-Gated Calcium Channel, Cacophony, in Regulating Motor Function and Behavior. | J Exp Neurosci | 2017 Nov 15 | Lembke KM | doi: 10.1177/1179069517740892 |
| 29191947 | A proteomic network approach across the ALS-FTD disease spectrum resolves clinical phenotypes and genetic vulnerability in human brain. | EMBO Mol Med | 2018 Jan | Umoh ME | doi: 10.15252/emmm.201708202. |
| 29203801 | De novo design of RNA-binding proteins with a prion-like domain related to ALS/FTD proteinopathies. | Sci Rep | 2017 Dec 4 | Mitsuhashi K | doi: 10.1038/s41598-017-17209-0. |
| 29233983 | Endocytosis regulates TDP-43 toxicity and turnover. | Nat Commun | 2017 Dec 12 | Liu G | doi: 10.1038/s41467-017-02017-x. |
| 29243911 | Neurodegenerative Disease Proteinopathies Are Connected to Distinct Histone Post-translational Modification Landscapes. | ACS Chem Neurosci | 2018 Apr 18 | Chen K | doi: 10.1021/acschemneuro.7b00297 |
| 29308690 | Overexpression of a conserved HSP40 chaperone reduces toxicity of several neurodegenerative disease proteins. | Prion | 2018 Jan 2 | Park SK | doi: 10.1080/19336896.2017.1423185 |
| 29431050 | TDP-43 post-translational modifications in health and disease. | Expert Opin Ther Targets | 2018 Mar | Buratti E | doi: 10.1080/14728222.2018.1439923 |
| 29438978 | A single N-terminal phosphomimic disrupts TDP-43 polymerization, phase separation, and RNA splicing. | EMBO J | 2018 Mar 1 | Wang A | doi: 10.15252/embj.201797452 |
| 29474575 | TDP-43 controls lysosomal pathways thereby determining its own clearance and cytotoxicity. | Hum Mol Genet | 2018 May 1 | Leibiger C | doi: 10.1093/hmg/ddy066. |
| 29545601 | TDP43 nuclear export and neurodegeneration in models of amyotrophic lateral sclerosis and frontotemporal dementia. | Sci Rep | 2018 Mar 15 | Archbold HC | doi: 10.1038/s41598-018-22858-w. |
| 29562314 | TDP-43 regulates the alternative splicing of hnRNP A1 to yield an aggregation-prone variant in amyotrophic lateral sclerosis. | Brain | 2018 May 1 | Deshaies JE | doi: 10.1093/brain/awy062. |
| 29650702 | RNA buffers the phase separation behavior of prion-like RNA binding proteins. | Science | 2018 May 25 | Maharana S | doi: 10.1126/science.aar7366 |
| 29728564 | Nuclear egress of TDP-43 and FUS occurs independently of Exportin-1/CRM1. | Sci Rep | 2018 May 4 | Ederle H | doi: 10.1038/s41598-018-25007-5. |
| 29728608 | Active nuclear import and passive nuclear export are the primary determinants of TDP-43 localization. | Sci Rep | 2018 May 4 | Pinarbasi ES | doi: 10.1038/s41598-018-25008-4. |
| 29764981 | Mice with endogenous TDP-43 mutations exhibit gain of splicing function and characteristics of amyotrophic lateral sclerosis. | EMBO J | 2018 Jun 1 | Fratta P | doi: 10.15252/embj.201798684 |
| 29866003 | The Effect of Single and Double Acetylation of Lysine Residues on Structural and Dynamical Features of Human Splicing Factor TDP-43 - A Statistical Ensemble Analysis. | Comb Chem High Throughput Screen | 2018 | Makhouri FR | doi: 10.2174/1386207321666180604125334. |
| 29872735 | Analysis of the substrate recognition state of TDP-43 to single-stranded DNA using fluorescence correlation spectroscopy. | Biochem Biophys Rep | 2018 Apr 12 | Kitamura A | doi: 10.1016/j.bbrep.2018.03.009 |
| 29881994 | Transcriptome-pathology correlation identifies interplay between TDP-43 and the expression of its kinase CK1E in sporadic ALS. | Acta Neuropathol | 2018 Sep | Krach F | doi: 10.1007/s00401-018-1870-7 |
| 29941967 | Accumulation of poly(A) RNA in nuclear granules enriched in Sam68 in motor neurons from the SMNdelta7 mouse model of SMA. | Sci Rep | 2018 Jun 25 | Narcis JO | doi: 10.1038/s41598-018-27821-3. |
| 29954341 | TDP-43 as a potential biomarker for amyotrophic lateral sclerosis: a systematic review and meta-analysis. | BMC Neurol | 2018 Jun 28 | Majumder V | doi: 10.1186/s12883-018-1091-7. |
| 30003873 | Unexpected similarities between C9ORF72 and sporadic forms of ALS/FTD suggest a common disease mechanism. | Elife | 2018 Jul 13 | Conlon EG | doi: 10.7554/eLife.37754. |
| 30030424 | Abnormal RNA stability in amyotrophic lateral sclerosis. | Nat Commun | 2018 Jul 20 | Tank EM | doi: 10.1038/s41467-018-05049-z. |
| 30128653 | Memory Decline and Its Reversal in Aging and Neurodegeneration Involve miR-183/96/182 Biogenesis. | Mol Neurobiol | 2019 May | Jawaid A | doi: 10.1007/s12035-018-1314-3 |
| 30099725 | Molecular chaperone HSP70 prevents formation of inclusion bodies of the 25-kDa C-terminal fragment of TDP-43 by preventing aggregate accumulation. | Cell Stress Chaperones | 2018 Nov | Kitamura A | doi: 10.1007/s12192-018-0930-1 |
| 30157547 | RNA-Binding Proteins in Amyotrophic Lateral Sclerosis. | Mol Cells | 2018 Sep 30 | Zhao M | doi: 10.14348/molcells.2018.0243 |
| 30237395 | Distinct multilevel misregulations of Parkin and PINK1 revealed in cell and animal models of TDP-43 proteinopathy. | Cell Death Dis | 2018 Sep 20 | Sun X | doi: 10.1038/s41419-018-1022-y. |
| 30290270 | Single-copy expression of an amyotrophic lateral sclerosis-linked TDP-43 mutation (M337V) in BAC transgenic mice leads to altered stress granule dynamics and progressive motor dysfunction. | Neurobiol Dis | 2019 Jan | Gordon D | doi: 10.1016/j.nbd.2018.09.024 |
| 30355151 | RNA Binding Proteins and the Pathogenesis of Frontotemporal Lobar Degeneration. | Annu Rev Pathol | 2019 Jan 24 | Hofmann JW | doi: 10.1146/annurev-pathmechdis-012418-012955 |
| 30356856 | The RNA-Recognition Motifs of TAR DNA-Binding Protein 43 May Play a Role in the Aberrant Self-Assembly of the Protein. | Front Mol Neurosci | 2018 Oct 9 | Zacco E | doi: 10.3389/fnmol.2018.00372 |
| 30357366 | TDP-43 enhances translation of specific mRNAs linked to neurodegenerative disease. | Nucleic Acids Res | 2019 Jan 10 | Neelagandan N | doi: 10.1093/nar/gky972. |
| 30464263 | TDP-43 and RNA form amyloid-like myo-granules in regenerating muscle. | Nature | 2018 Nov | Vogler TO | doi: 10.1038/s41586-018-0665-2 |
| 30618614 | Transcriptomic Analysis of Zebrafish TDP-43 Transgenic Lines. | Front Mol Neurosci | 2018 Dec 13 | Lissouba A | doi: 10.3389/fnmol.2018.00463 |
| 30660504 | Therapeutic Dissolution of Aberrant Phases by Nuclear-Import Receptors. | Trends Cell Biol | 2019 Apr | Guo L | doi: 10.1016/j.tcb.2018.12.004 |
| 30692134 | Abnormal TDP-43 function impairs activity-dependent BDNF secretion, synaptic plasticity, and cognitive behavior through altered Sortilin splicing. | EMBO J | 2019 Mar 1 | Tann JY | doi: 10.15252/embj.2018100989 |
| 30694439 | 1H, 15N and 13C backbone assignment of apo TDP-43 RNA recognition motifs. | Biomol NMR Assign | 2019 Apr | Scott DD | doi: 10.1007/s12104-018-09870-x |
| 30728452 | PARylation regulates stress granule dynamics, phase separation, and neurotoxicity of disease-related RNA-binding proteins. | Cell Res | 2019 Mar | Duan Y | doi: 10.1038/s41422-019-0141-z |
| 30826182 | RNA Binding Antagonizes Neurotoxic Phase Transitions of TDP-43. | Neuron | 2019 Apr 17 | Mann JR | doi: 10.1016/j.neuron.2019.01.048 |
| 30948513 | Phase separation of RNA-binding proteins in physiology and disease: An introduction to the JBC Reviews thematic series. | J Biol Chem | 2019 May 3 | Shorter J | doi: 10.1074/jbc.REV119.007944 |
| 30992467 | RNA recognition motifs of disease-linked RNA-binding proteins contribute to amyloid formation. | Sci Rep | 2019 Apr 16 | Agrawal S | doi: 10.1038/s41598-019-42367-8. |
| 31019288 | N-terminal sequences in matrin 3 mediate phase separation into droplet-like structures that recruit TDP43 variants lacking RNA binding elements. | Lab Invest | 2019 Jul | Gallego-Iradi MC | doi: 10.1038/s41374-019-0260-7 |
| 31019368 | Myo-granules Connect Physiology and Pathophysiology. | J Exp Neurosci | 2019 Apr 12 | Cutler AA | doi: 10.1177/1179069519842157 |
| 31031584 | The Pathobiology of TDP-43 C-Terminal Fragments in ALS and FTLD. | Front Neurosci | 2019 Apr 11 | Berning BA | doi: 10.3389/fnins.2019.00335 |
| 31062657 | TDP-43 is Required for Mammary Gland Repopulation and Proliferation of Mammary Epithelial Cells. | Stem Cells Dev | 2019 Jul 15 | Zhao L | doi: 10.1089/scd.2019.0011 |
| 31118120 | Structural Transition, Function and Dysfunction of TDP-43 in Neurodegenerative Diseases. | Chimia (Aarau) | 2019 May 29 | Afroz T | doi: 10.2533/chimia.2019.380. |
| 31186504 | Regulation of the Hepatitis B virus replication and gene expression by the multi-functional protein TARDBP. | Sci Rep | 2019 Jun 11 | Makokha GN | doi: 10.1038/s41598-019-44934-5. |
| 31252669 | Extracellular RNAs as Biomarkers of Sporadic Amyotrophic Lateral Sclerosis and Other Neurodegenerative Diseases. | Int J Mol Sci | 2019 Jun 27 | Hosaka T | doi: 10.3390/ijms20133148. |
| 31316455 | The Role of TDP-43 in Military-Relevant TBI and Chronic Neurodegeneration. | Front Neurol | 2019 Jun 27 | Heyburn L | doi: 10.3389/fneur.2019.00680 |
| 30837838 | Molecular Mechanisms of TDP-43 Misfolding and Pathology in Amyotrophic Lateral Sclerosis. | Front Mol Neurosci | 2019 Feb 14 | Prasad A | doi: 10.3389/fnmol.2019.00025 |
| 23264567 | Neurodegenerative diseases: quantitative predictions of protein-RNA interactions. | RNA | 2013 Feb | Cirillo D | doi: 10.1261/rna.034777.112 |
| 24355598 | The molecular link between inefficient GluA2 Q/R site-RNA editing and TDP-43 pathology in motor neurons of sporadic amyotrophic lateral sclerosis patients. | Brain Res | 2014 Oct 10 | Yamashita T | doi: 10.1016/j.brainres.2013.12.011 |
| 29944911 | Cell death cascade and molecular therapy in ADAR2-deficient motor neurons of ALS. | Neurosci Res | 2019 Jul | Yamashita T | doi: 10.1016/j.neures.2018.06.004 |
| 21881207 | The ALS-associated proteins FUS and TDP-43 function together to affect Drosophila locomotion and life span. | J Clin Invest | 2011 Oct | Wang JW | doi: 10.1172/JCI57883 |
| 28952053 | TDP-43 regulates cancer-associated microRNAs. | Protein Cell | 2018 Oct | Chen X | doi: 10.1007/s13238-017-0480-9 |
| 29513014 | RNA and Protein Interactors with TDP-43 in Human Spinal-Cord Lysates in Amyotrophic Lateral Sclerosis. | J Proteome Res | 2018 Apr 6 | Volkening K | doi: 10.1021/acs.jproteome.8b00126 |
| 24698978 | Distinct pathways leading to TDP-43-induced cellular dysfunctions. | Hum Mol Genet | 2014 Aug 15 | Yamashita M | doi: 10.1093/hmg/ddu152 |
| 28330421 | The proteinopathy of D169G and K263E mutants at the RNA Recognition Motif (RRM) domain of tar DNA-binding protein (tdp43) causing neurological disorders: A computational study. | J Biomol Struct Dyn | 2018 Mar | Bhandare VV | doi: 10.1080/07391102.2017.1310670 |
| 15479789 | Nuclear heat shock response and novel nuclear domain 10 reorganization in respiratory syncytial virus-infected a549 cells identified by high-resolution two-dimensional gel electrophoresis. | J Virol | 2004 Nov | Brasier AR | - |
| 19815002 | Tar DNA binding protein of 43 kDa (TDP-43), 14-3-3 proteins and copper/zinc superoxide dismutase (SOD1) interact to modulate NFL mRNA stability. Implications for altered RNA processing in amyotrophic lateral sclerosis (ALS). | Brain Res | 2009 Dec 11 | Volkening K | doi: 10.1016/j.brainres.2009.09.105 |
| 17981595 | Multiple roles of TDP-43 in gene expression, splicing regulation, and human disease. | Front Biosci | 2008 Jan 1 | Buratti E | - |
| 22718532 | Asparaginyl endopeptidase cleaves TDP-43 in brain. | Proteomics | 2012 Aug | Herskowitz JH | doi: 10.1002/pmic.201200006. |
| 22570068 | [Molecular link between inefficient GluA2 RNA editing and TDP-43 pathology in ALS motor neurons]. | Brain Nerve | 2012 May | Kwak S | - |
| 23300771 | Conserved acidic amino acid residues in a second RNA recognition motif regulate assembly and function of TDP-43. | PLoS One | 2012 | Shodai A | doi: 10.1371/journal.pone.0052776 |
| 21450909 | Aggregation of the 35-kDa fragment of TDP-43 causes formation of cytoplasmic inclusions and alteration of RNA processing. | FASEB J | 2011 Jul | Che MX | doi: 10.1096/fj.10-174482 |
| 20372915 | TDP-43 pathology in sporadic ALS occurs in motor neurons lacking the RNA editing enzyme ADAR2. | Acta Neuropathol | 2010 Jul | Aizawa H | doi: 10.1007/s00401-010-0678-x |
| 25171271 | Binding of TDP-43 to the 3'UTR of its cognate mRNA enhances its solubility. | Biochemistry | 2014 Sep 23 | Sun Y | doi: 10.1021/bi500617x |
| 24497641 | Folding of the RNA recognition motif (RRM) domains of the amyotrophic lateral sclerosis (ALS)-linked protein TDP-43 reveals an intermediate state. | J Biol Chem | 2014 Mar 21 | Mackness BC | doi: 10.1074/jbc.M113.542779 |
| 24323933 | [Neuropathology of TDP-43 proteinopathy]. | Brain Nerve | 2013 Dec | Akiyama H | - |
| 23867462 | Fused in sarcoma (FUS) protein lacking nuclear localization signal (NLS) and major RNA binding motifs triggers proteinopathy and severe motor phenotype in transgenic mice. | J Biol Chem | 2013 Aug 30 | Shelkovnikova TA | doi: 10.1074/jbc.M113.492017 |
| 23827811 | Transcriptome-wide analysis of TDP-43 binding small RNAs identifies miR-NID1 (miR-8485), a novel miRNA that represses NRXN1 expression. | Genomics | 2014 Jan | Fan Z | doi: 10.1016/j.ygeno.2013.06.006 |
| 23558684 | Aberrant assembly of RNA recognition motif 1 links to pathogenic conversion of TAR DNA-binding protein of 43 kDa (TDP-43). | J Biol Chem | 2013 May 24 | Shodai A | doi: 10.1074/jbc.M113.451849 |
| 25270903 | A new cellular model of pathological TDP-43: The neurotoxicity of stably expressed CTF25 of TDP-43 depends on the proteasome. | Neuroscience | 2014 Dec 5 | Liu Y | doi: 10.1016/j.neuroscience.2014.09.043 |
| 27535427 | Role of BMP receptor traffic in synaptic growth defects in an ALS model. | Mol Biol Cell | 2016 Oct 1 | Deshpande M | doi: 10.1091/mbc.E16-07-0519 |
| 28421535 | MicroRNA Metabolism and Dysregulation in Amyotrophic Lateral Sclerosis. | Mol Neurobiol | 2018 Mar | Rinchetti P | doi: 10.1007/s12035-017-0537-z |
| 29279008 | Comparative analysis of thermal unfolding simulations of RNA recognition motifs (RRMs) of TAR DNA-binding protein 43 (TDP-43). | J Biomol Struct Dyn | 2019 Jan | Prakash A | doi: 10.1080/07391102.2017.1422026 |
| 29499929 | Inhibition of TDP43-Mediated SNHG12-miR-195-SOX5 Feedback Loop Impeded Malignant Biological Behaviors of Glioma Cells. | Mol Ther Nucleic Acids | 2018 Mar 2 | Liu X | doi: 10.1016/j.omtn.2017.12.001 |
| 29577934 | Selective Spatiotemporal Vulnerability of Central Nervous System Neurons to Pathologic TAR DNA-Binding Protein 43 in Aged Transgenic Mice. | Am J Pathol | 2018 Jun | van Hummel A | doi: 10.1016/j.ajpath.2018.03.002 |
| 30774737 | Molecular Mechanisms of Neurodegeneration Related to C9orf72 Hexanucleotide Repeat Expansion. | Behav Neurol | 2019 Jan 15 | Babic Leko M | doi: 10.1155/2019/2909168 |
| 7745706 | Cloning and characterization of a novel cellular protein, TDP-43, that binds to human immunodeficiency virus type 1 TAR DNA sequence motifs. | J Virol | 1995 Jun | Ou SH | - |
| 11285240 | Nuclear factor TDP-43 and SR proteins promote in vitro and in vivo CFTR exon 9 skipping. | EMBO J | 2001 Apr 2 | Buratti E | - |
| 19539030 | TDP-43 localizes in mRNA transcription and processing sites in mammalian neurons. | J Struct Biol | 2009 Sep | Casafont I | doi: 10.1016/j.jsb.2009.06.006 |
| 19383787 | Aberrant cleavage of TDP-43 enhances aggregation and cellular toxicity. | Proc Natl Acad Sci U S A | 2009 May 5 | Zhang YJ | doi: 10.1073/pnas.0900688106 |
| 22323604 | TDP-43 promotes microRNA biogenesis as a component of the Drosha and Dicer complexes. | Proc Natl Acad Sci U S A | 2012 Feb 28 | Kawahara Y | doi: 10.1073/pnas.1112427109 |
| 21681666 | TDP-43 autoregulation: implications for disease. | J Mol Neurosci | 2011 Nov | Budini M | doi: 10.1007/s12031-011-9573-8 |
| 21173160 | TDP-43 is directed to stress granules by sorbitol, a novel physiological osmotic and oxidative stressor. | Mol Cell Biol | 2011 Mar | Dewey CM | doi: 10.1128/MCB.01279-10 |
| 20948999 | Tar DNA binding protein-43 (TDP-43) associates with stress granules: analysis of cultured cells and pathological brain tissue. | PLoS One | 2010 Oct 11 | Liu-Yesucevitz L | doi: 10.1371/journal.pone.0013250. |
| 20888804 | Progranulin deficiency leads to enhanced cell vulnerability and TDP-43 translocation in primary neuronal cultures. | Brain Res | 2010 Dec 17 | Guo A | doi: 10.1016/j.brainres.2010.09.099 |
| 20406185 | Neuronal death in amyotrophic lateral sclerosis (ALS): what can we learn from genetics? | CNS Neurol Disord Drug Targets | 2010 Jul | Sreedharan J | - |
| 24690345 | Novel monoclonal antibodies to normal and pathologically altered human TDP-43 proteins. | Acta Neuropathol Commun | 2014 Mar 31 | Kwong LK | doi: 10.1186/2051-5960-2-33. |
| 26915990 | TDP-43 binds and transports G-quadruplex-containing mRNAs into neurites for local translation. | Genes Cells | 2016 May | Ishiguro A | doi: 10.1111/gtc.12352 |
| 26751167 | CUL2-mediated clearance of misfolded TDP-43 is paradoxically affected by VHL in oligodendrocytes in ALS. | Sci Rep | 2016 Jan 11 | Uchida T | doi: 10.1038/srep19118. |
| 27164932 | Comparative interactomics analysis of different ALS-associated proteins identifies converging molecular pathways. | Acta Neuropathol | 2016 Aug | Blokhuis AM | doi: 10.1007/s00401-016-1575-8 |
| 26219309 | Rapamycin alleviates pathogenesis of a new Drosophila model of ALS-TDP. | J Neurogenet | 2015 | Cheng CW | doi: 10.3109/01677063.2015.1077832 |
| 26064939 | Novel Mechanisms of Spinal Cord Plasticity in a Mouse Model of Motoneuron Disease. | Biomed Res Int | 2015 | Gulino R | doi: 10.1155/2015/654637 |
| 25845943 | InSAC: A novel sub-nuclear body essential for Interleukin-6 and -10 RNA processing and stability. | BMB Rep | 2015 May | Lee S | - |
| 28466273 | TDP-43 and Cytoskeletal Proteins in ALS. | Mol Neurobiol | 2018 Apr | Oberstadt M | doi: 10.1007/s12035-017-0543-1 |
| 28472174 | Augmented quantal release of acetylcholine at the vertebrate neuromuscular junction following tdp-43 depletion. | PLoS One | 2017 May 4 | Dzieciolowska S | doi: 10.1371/journal.pone.0177005 |
| 28497562 | Different aggregation states of a nuclear localization signal-tagged 25-kDa C-terminal fragment of TAR RNA/DNA-binding protein 43kDa. | Genes Cells | 2017 Jun | Kitamura A | doi: 10.1111/gtc.12495 |
| 28531192 | Overexpression of the essential Sis1 chaperone reduces TDP-43 effects on toxicity and proteolysis. | PLoS Genet | 2017 May 22 | Park SK | doi: 10.1371/journal.pgen.1006805 |
| 28611593 | Autophagy and Its Impact on Neurodegenerative Diseases: New Roles for TDP-43 and C9orf72. | Front Mol Neurosci | 2017 May 30 | Budini M | doi: 10.3389/fnmol.2017.00170 |
| 29125873 | U6 snRNA expression prevents toxicity in TDP-43-knockdown cells. | PLoS One | 2017 Nov 10 | Yahara M | doi: 10.1371/journal.pone.0187813 |
| 30157956 | Nuclear poly(ADP-ribose) activity is a therapeutic target in amyotrophic lateral sclerosis. | Acta Neuropathol Commun | 2018 Aug 29 | McGurk L | doi: 10.1186/s40478-018-0586-1. |
| 30770445 | Motor neuron disease-associated loss of nuclear TDP-43 is linked to DNA double-strand break repair defects. | Proc Natl Acad Sci U S A | 2019 Feb 15 | Mitra J | doi: 10.1073/pnas.1818415116 |
| 31067307 | Amyotrophic lateral sclerosis-associated TDP-43 mutation Q331K prevents nuclear translocation of XRCC4-DNA ligase 4 complex and is linked to genome damage-mediated neuronal apoptosis. | Hum Mol Genet | 2019 Apr 1 | Guerrero EN | doi: 10.1093/hmg/ddz062 |
| 31259382 | localizes to atherosclerotic lesions of human carotid and main cerebral arteries. | Histol Histopathol | 2019 Jul 1:18140 | Umahara T | doi: 10.14670/HH-18-140 |
