EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
26902425	High TDP43 expression is required for TRIM16-induced inhibition of cancer cell growth and correlated with good prognosis of neuroblastoma and breast cancer patients.	Cancer Lett	2016 May 1	Kim PY	doi: 10.1016/j.canlet.2016.02.021
26265046	Regulation of MALAT1 expression by TDP43 controls the migration and invasion of non-small cell lung cancer cells invitro.	Biochem Biophys Res Commun	2015 Sep 18	Guo F	doi: 10.1016/j.bbrc.2015.08.027
29581274	Loss of TDP43 inhibits progression of triple-negative breast cancer in coordination with SRSF3.	Proc Natl Acad Sci U S A	2018 Apr 10	Ke H	doi: 10.1073/pnas.1714573115

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
BLCA	chr1	11016937	Missense_Mutation	novel	L111R	0.08	RRM_1
BLCA	chr1	11022629	Missense_Mutation	NA	S407C	0.18
BLCA	chr1	11018738	Silent	novel	K136K	0.68
BLCA	chr1	11016877	Nonsense_Mutation	novel	S91*	0.28	RRM_1
BLCA	chr1	11018743	Missense_Mutation	NA	D138A	0.04
BRCA	chr1	11022371	Missense_Mutation	NA	A321V	0.23
CESC	chr1	11024832	3'UTR	novel		0.11
CESC	chr1	11013786	Missense_Mutation	NA	S20L	0.24
CESC	chr1	11025007	3'UTR	novel		0.38
CESC	chr1	11023378	3'UTR	novel		0.56
CESC	chr1	11018854	Missense_Mutation	novel	C175Y	0.25
CESC	chr1	11025000	3'UTR	novel		0.15
COAD	chr1	11023279	3'UTR	novel		0.14
COAD	chr1	11023370	3'UTR	novel		0.47
COAD	chr1	11020527	Silent	rs138201492	Y214Y	0.38
COAD	chr1	11016918	Missense_Mutation	NA	D105N	0.35	RRM_1
COAD	chr1	11016918	Missense_Mutation	NA	D105N	0.42	RRM_1
COAD	chr1	11020527	Silent	rs138201492	Y214Y	0.31
COAD	chr1	11022586	Missense_Mutation	novel	S393P	0.31
COAD	chr1	11013751	Silent	rs72870030	T8T	0.41
ESCA	chr1	11025341	3'UTR	novel		0.4
ESCA	chr1	11020563	Silent	novel	F226F	0.16
GBM	chr1	11016939	Missense_Mutation	novel	P112S	0.07	RRM_1
GBM	chr1	11022743	3'UTR	novel		0.39
HNSC	chr1	11020441	Missense_Mutation	novel	E186Q	0.13
HNSC	chr1	11013716	Splice_Region	novel		0.5
HNSC	chr1	11016900	Missense_Mutation	novel	A99T	0.25	RRM_1
HNSC	chr1	11016969	Missense_Mutation	novel	E122K	0.2	RRM_1
HNSC	chr1	11018761	Nonsense_Mutation	novel	S144*	0.12
HNSC	chr1	11022319	Missense_Mutation	novel	G304S	0.1
HNSC	chr1	11020478	Missense_Mutation	novel	C198Y	0.21
HNSC	chr1	11022148	Missense_Mutation	novel	D247N	0.1
LAML	chr1	11013898	Silent	novel	V57V	0.21
LAML	chr1	11022658	3'UTR	novel		0.03
LAML	chr1	11022659	3'UTR	novel		0.03
LIHC	chr1	11022926	3'UTR	novel		0.5
LIHC	chr1	11022977	3'UTR	novel		0.52
LUAD	chr1	11022340	Missense_Mutation	novel	M311L	0.06
LUAD	chr1	11018796	Missense_Mutation	NA	E156K	0.17
LUSC	chr1	11020563	Missense_Mutation	novel	F226L	0.29
LUSC	chr1	11013851	Missense_Mutation	novel	R42C	0.16
LUSC	chr1	11016950	Silent	NA	T115T	0.17
LUSC	chr1	11022769	3'UTR	novel		0.28
LUSC	chr1	11022629	Missense_Mutation	NA	S407C	0.07
OV	chr1	11018788	Missense_Mutation	NA	T153M	0.49
OV	chr1	11013952	Silent	NA	V75V	0.29
OV	chr1	11018799	Missense_Mutation	NA	T157A	0.34
OV	chr1	11022395	Missense_Mutation	NA	A329V	0.14
OV	chr1	11020474	Frame_Shift_Ins	novel	*R197Qfs8**	0.09
OV	chr1	11020475	Frame_Shift_Ins	novel	*C198Lfs10**	0.08
OV	chr1	11022207	Frame_Shift_Ins	novel	N267*	0.1
OV	chr1	11022209	Nonsense_Mutation	novel	*N267_R268insCYSLSF**	0.09
OV	chr1	11022142	Nonsense_Mutation	NA	G245*	0.34
PAAD	chr1	11022132	Silent	novel	Q241Q	0.11
READ	chr1	11020576	Missense_Mutation	novel	F231L	0.12
READ	chr1	11023461	3'UTR	novel		0.17
READ	chr1	11022834	3'UTR	novel		0.39
SKCM	chr1	11018856	Nonsense_Mutation	novel	K176*	0.11
SKCM	chr1	11016877	Missense_Mutation	NA	S91L	0.46	RRM_1
SKCM	chr1	11016994	Missense_Mutation	novel	V130A	0.13
SKCM	chr1	11016944	Missense_Mutation	novel	W113C	0.28	RRM_1
STAD	chr1	11013743	Missense_Mutation	novel	R6W	0.31
STAD	chr1	11022129	Silent	rs765175133	A240A	0.44
STAD	chr1	11022510	Silent	rs377531374	F367F	0.28
STAD	chr1	11022510	Silent	rs377531374	F367F	0.25
STAD	chr1	11013903	Missense_Mutation	NA	G59E	0.24
STAD	chr1	11022587	Missense_Mutation	rs80356743	S393L	0.24
STAD	chr1	11016872	Silent	NA	D89D	0.19
STAD	chr1	11018817	Missense_Mutation	NA	S163P	0.24
UCEC	chr1	11020476	Silent	novel	R197R	0.09
UCEC	chr1	11023806	3'UTR	novel		0.39
UCEC	chr1	11024507	3'UTR	novel		0.39
UCEC	chr1	11022742	3'UTR	novel		0.45
UCEC	chr1	11023988	3'UTR	novel		0.57
UCEC	chr1	11024100	3'UTR	novel		0.55
UCEC	chr1	11024898	3'UTR	novel		0.34
UCEC	chr1	11016962	Silent	rs749962069	D119D	0.24
UCEC	chr1	11024981	3'UTR	novel		0.33
UCEC	chr1	11016916	Missense_Mutation	novel	S104F	0.44	RRM_1
UCEC	chr1	11023640	3'UTR	novel		0.45
UCEC	chr1	11013717	Splice_Region	novel		0.17
UCEC	chr1	11016954	Missense_Mutation	NA	E117K	0.23	RRM_1
UCEC	chr1	11020474	Missense_Mutation	NA	R197C	0.38
UCEC	chr1	11023350	3'UTR	novel		0.49
UCEC	chr1	11022469	Frame_Shift_Ins	novel	*N355Kfs18**	0.45
UCEC	chr1	11024963	3'UTR	novel		0.48
UCEC	chr1	11016888	Nonsense_Mutation	novel	K95*	0.47	RRM_1
UCEC	chr1	11016851	Silent	novel	K82K	0.35
UCEC	chr1	11023417	3'UTR	novel		0.33
UCEC	chr1	11025043	3'UTR	novel		0.56
UCEC	chr1	11022560	Frame_Shift_Ins	novel	*W385Lfs14**	0.03
UCEC	chr1	11023111	3'UTR	novel		0.27
UCEC	chr1	11020475	Missense_Mutation	novel	R197H	0.47
UCEC	chr1	11022212	Missense_Mutation	novel	R268I	0.46
UCEC	chr1	11016954	Missense_Mutation	NA	E117K	0.57	RRM_1
UCEC	chr1	11024739	3'UTR	novel		0.29
UCEC	chr1	11025105	3'UTR	novel		0.16
UCEC	chr1	11016954	Missense_Mutation	NA	E117K	0.39	RRM_1
UCEC	chr1	11016887	Silent	novel	V94V	0.28
UCEC	chr1	11016977	Missense_Mutation	novel	F124L	0.35
UCEC	chr1	11025072	3'UTR	novel		0.33
UCEC	chr1	11025238	3'UTR	novel		0.25
UCEC	chr1	11022712	3'UTR	novel		0.25
UCEC	chr1	11023243	3'UTR	novel		0.21
UCEC	chr1	11024490	3'UTR	novel		0.3
UCEC	chr1	11025245	3'UTR	novel		0.19
UCEC	chr1	11023698	3'UTR	novel		0.39
UCEC	chr1	11023022	3'UTR	novel		0.24
UCEC	chr1	11013720	5'UTR	novel		0.49
UCEC	chr1	11023297	3'UTR	novel		0.4
UCEC	chr1	11024679	3'UTR	novel		0.43
UCEC	chr1	11022682	3'UTR	novel		0.45
UCEC	chr1	11022371	Missense_Mutation	NA	A321G	0.17
UCEC	chr1	11017008	Splice_Site	novel	X134_splice	0.06
UCEC	chr1	11024037	3'UTR	novel		0.11
UCEC	chr1	11022128	Missense_Mutation	NA	A240V	0.44
UCEC	chr1	11022596	Frame_Shift_Ins	novel	*F397Yfs8**	0.06
UCEC	chr1	11020527	Silent	rs138201492	Y214Y	0.25
UCEC	chr1	11023622	3'UTR	novel		0.28
UCEC	chr1	11024216	3'UTR	novel		0.46
UCEC	chr1	11022980	3'UTR	novel		0.35
UCEC	chr1	11022254	Missense_Mutation	novel	G282D	0.32
UCEC	chr1	11022703	3'UTR	novel		0.4
UCEC	chr1	11023354	3'UTR	novel		0.5
UCEC	chr1	11022936	3'UTR	novel		0.4

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
CESC	DEL	0.1085	0.00029523
CHOL	DEL	0.7778	3.3987e-23
DLBC	DEL	0.1042	0.011841
HNSC	DEL	0.1398	7.0766e-07
KIRC	DEL	0.1439	2.3538e-09
KIRP	DEL	0.1736	1.462e-09
LUAD	DEL	0.1434	0.0024765
LUSC	DEL	0.3653	2.5882e-07
MESO	DEL	0.3333	2.434e-07
READ	DEL	0.3939	2.1758e-10
TGCT	DEL	0.18	0.00046313
UCS	DEL	0.3036	0.0051125

Survival Analysis

Cancer	P-value	Q-value
THYM	0.0025	Kaplan-Meier Survival Analysis
SARC	0.00017	Kaplan-Meier Survival Analysis
ACC	0.00029	Kaplan-Meier Survival Analysis
UCS	0.019	Kaplan-Meier Survival Analysis
SKCM	0.02	Kaplan-Meier Survival Analysis
LUSC	0.011	Kaplan-Meier Survival Analysis
BRCA	0.014	Kaplan-Meier Survival Analysis
KIRP	0.023	Kaplan-Meier Survival Analysis
BLCA	0.031	Kaplan-Meier Survival Analysis
CESC	0.0002	Kaplan-Meier Survival Analysis
READ	0.045	Kaplan-Meier Survival Analysis
KICH	0.0081	Kaplan-Meier Survival Analysis
UCEC	0.037	Kaplan-Meier Survival Analysis
LIHC	0.00011	Kaplan-Meier Survival Analysis
DLBC	0.0066	Kaplan-Meier Survival Analysis
LGG	0.00019	Kaplan-Meier Survival Analysis
OV	0.027	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBDs

RBPome

PRI

Literatures

Expression

Transcripts

Gene Model

GWAS

PPI

Paralog

Ortholog

Gene Ontology

Description

Ensembl ID: ENSG00000120948 (Gene tree)
Gene ID: 23435
Gene Symbol: TARDBP
Alias: TDP-43|ALS10
Full Name: TAR DNA binding protein
Gene Type: protein_coding
Specie: Homo_sapiens
Strand: Plus strand
Length: 14,077 bases
Position: chr1:11,012,344-11,026,420
Accession: 11571
Summary: HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator Tat is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. The protein encoded by this gene is a transcriptional repressor that binds to chromosomally integrated TAR DNA and represses HIV-1 transcription. In addition, this protein regulates alternate splicing of the CFTR gene. A similar pseudogene is present on chromosome 20. [provided by RefSeq, Jul 2008]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000481206	RRM_1	PF00076.22	6.7e-29	1	2
ENSP00000481206	RRM_1	PF00076.22	6.7e-29	2	2
ENSP00000479219	RRM_1	PF00076.22	8.3e-29	1	2
ENSP00000479219	RRM_1	PF00076.22	8.3e-29	2	2
ENSP00000497327	RRM_1	PF00076.22	1.9e-28	1	2
ENSP00000497327	RRM_1	PF00076.22	1.9e-28	2	2
ENSP00000313129	RRM_1	PF00076.22	2.4e-28	1	2
ENSP00000313129	RRM_1	PF00076.22	2.4e-28	2	2
ENSP00000486989	RRM_1	PF00076.22	2.5e-28	1	2
ENSP00000486989	RRM_1	PF00076.22	2.5e-28	2	2
ENSP00000482191	RRM_1	PF00076.22	2.6e-28	1	2
ENSP00000482191	RRM_1	PF00076.22	2.6e-28	2	2
ENSP00000484722	RRM_1	PF00076.22	2.7e-28	1	2
ENSP00000484722	RRM_1	PF00076.22	2.7e-28	2	2
ENSP00000240185	RRM_1	PF00076.22	6.5e-28	1	2
ENSP00000240185	RRM_1	PF00076.22	6.5e-28	2	2
ENSP00000491203	RRM_1	PF00076.22	6.5e-28	1	2
ENSP00000491203	RRM_1	PF00076.22	6.5e-28	2	2
ENSP00000466842	RRM_1	PF00076.22	1e-26	1	2
ENSP00000466842	RRM_1	PF00076.22	1e-26	2	2
ENSP00000465240	RRM_1	PF00076.22	6.4e-15	1	1
ENSP00000480690	RRM_1	PF00076.22	9.2e-15	1	1
ENSP00000482559	RRM_1	PF00076.22	3.2e-11	1	1
ENSP00000491085	RRM_1	PF00076.22	5.4e-06	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	NascentRICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	PolyT & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	polyT & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
27453046	Comprehensive Identification of RNA-Binding Domains in Human Cells	PolyT & Hela	2016 Aug 18	Castello A	DOI: 10.1016/j.molcel.2016.06.029
30352994	Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome capture	RIC & Jurkat	2018 Oct 23	Perez-Perri JI	DOI:10.1038/s41467-018-06557-8

RNA-binding sites

Click here to download all RNA binding sites

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
28980860	behavior of proteins involved in amyotrophic lateral sclerosis and frontotemporal lobar degeneration.	Autophagy	2017	Uversky VN	doi: 10.1080/15548627.2017.1384889
27226551	Developmentally Regulated RNA-binding Protein 1 (Drb1)/RNA-binding Motif Protein 45 (RBM45), a Nuclear-Cytoplasmic Trafficking Protein, Forms TAR DNA-binding Protein 43 (TDP-43)-mediated Cytoplasmic Aggregates.	J Biol Chem	2016 Jul 15	Mashiko T	doi: 10.1074/jbc.M115.712232
27033831	Mechanisms of FUS mutations in familial amyotrophic lateral sclerosis.	Brain Res	2016 Sep 15	Shang Y	doi: 10.1016/j.brainres.2016.03.036
28090150	M1 and M2 Functional Imprinting of Primary Microglia: Role of P2X7 Activation and miR-125b.	Mediators Inflamm	2016	Parisi C	doi: 10.1155/2016/2989548
23474849	RNA dysfunction and aggrephagy at the centre of an amyotrophic lateral sclerosis/frontotemporal dementia disease continuum.	Brain	2013 May	Thomas M	doi: 10.1093/brain/awt030
26510133	Transcriptomic Changes Due to Cytoplasmic TDP-43 Expression Reveal Dysregulation of Histone Transcripts and Nuclear Chromatin.	PLoS One	2015 Oct 28	Amlie-Wolf A	doi: 10.1371/journal.pone.0141836
22028183	RNA-binding proteins in neurodegenerative disease: TDP-43 and beyond.	Wiley Interdiscip Rev RNA	2012 Mar-Apr	Hanson KA	doi: 10.1002/wrna.111
24113842	TDP-43 regulates the microprocessor complex activity during in vitro neuronal differentiation.	Mol Neurobiol	2013 Dec	Di Carlo V	doi: 10.1007/s12035-013-8564-x
23975767	catRAPID omics: a web server for large-scale prediction of protein-RNA interactions.	Bioinformatics	2013 Nov 15	Agostini F	doi: 10.1093/bioinformatics/btt495
23804749	RNA binding mediates neurotoxicity in the transgenic Drosophila model of TDP-43 proteinopathy.	Hum Mol Genet	2013 Nov 15	Ihara R	doi: 10.1093/hmg/ddt296
28167528	Heat Shock-induced Phosphorylation of TAR DNA-binding Protein 43 (TDP-43) by MAPK/ERK Kinase Regulates TDP-43 Function.	J Biol Chem	2017 Mar 24	Li W	doi: 10.1074/jbc.M116.753913
26838063	A molecular mechanism realizing sequence-specific recognition of nucleic acids by TDP-43.	Sci Rep	2016 Feb 3	Furukawa Y	doi: 10.1038/srep20576.
26672899	Analysis of RNA metabolism in peripheral WBCs of TDP-43 KI mice identifies novel biomarkers of ALS.	Neurosci Res	2016 May	Hasegawa M	doi: 10.1016/j.neures.2015.11.009
26525917	MTHFSD and DDX58 are novel RNA-binding proteins abnormally regulated in amyotrophic lateral sclerosis.	Brain	2016 Jan	MacNair L	doi: 10.1093/brain/awv308
28600885	Immunolocalization of TAR DNA-binding protein of 43kDa (TDP-43) in mouse seminiferous epithelium.	Mol Reprod Dev	2017 Aug	Osuru HP	doi: 10.1002/mrd.22851
31132467	Cytoplasmic functions of TDP-43 and FUS and their role in ALS.	Semin Cell Dev Biol	2019 Jun 4	Birsa N	doi: 10.1016/j.semcdb.2019.05.023
31345270	Mice deficient in the C-terminal domain of TAR DNA-binding protein 43 develop age-dependent motor dysfunction associated with impaired Notch1-Akt signaling pathway.	Acta Neuropathol Commun	2019 Jul 25	Nishino K	doi: 10.1186/s40478-019-0776-5.
17481916	TDP43 is a human low molecular weight neurofilament (hNFL) mRNA-binding protein.	Mol Cell Neurosci	2007 Jun	Strong MJ	-
22079416	Neurodegeneration the RNA way.	Prog Neurobiol	2012 May	Renoux AJ	doi: 10.1016/j.pneurobio.2011.10.006
23280309	RNA-mediated toxicity in neurodegenerative disease.	Mol Cell Neurosci	2013 Sep	Belzil VV	doi: 10.1016/j.mcn.2012.12.006
21358643	Long pre-mRNA depletion and RNA missplicing contribute to neuronal vulnerability from loss of TDP-43.	Nat Neurosci	2011 Apr	Polymenidou M	doi: 10.1038/nn.2779
20736350	Altered distributions of Gemini of coiled bodies and mitochondria in motor neurons of TDP-43 transgenic mice.	Proc Natl Acad Sci U S A	2010 Sep 14	Shan X	doi: 10.1073/pnas.1003459107
20660762	Deletion of TDP-43 down-regulates Tbc1d1, a gene linked to obesity, and alters body fat metabolism.	Proc Natl Acad Sci U S A	2010 Sep 14	Chiang PM	doi: 10.1073/pnas.1002176107
28072389	Suppression of C9orf72 RNA repeat-induced neurotoxicity by the ALS-associated RNA-binding protein Zfp106.	Elife	2017 Jan 10	Celona B	doi: 10.7554/eLife.19032.
26614389	TDP-43 functions within a network of hnRNP proteins to inhibit the production of a truncated human SORT1 receptor.	Hum Mol Genet	2016 Feb 1	Mohagheghi F	doi: 10.1093/hmg/ddv491
26056265	Amelioration of toxicity in neuronal models of amyotrophic lateral sclerosis by hUPF1.	Proc Natl Acad Sci U S A	2015 Jun 23	Barmada SJ	doi: 10.1073/pnas.1509744112
29916022	Mechanisms Associated with TDP-43 Neurotoxicity in ALS/FTLD.	Adv Neurobiol	2018	Shenouda M	doi: 10.1007/978-3-319-89689-2_9.
22444279	Misregulated RNA processing in amyotrophic lateral sclerosis.	Brain Res	2012 Jun 26	Polymenidou M	doi: 10.1016/j.brainres.2012.02.059
24507191	Axonal transport of TDP-43 mRNA granules is impaired by ALS-causing mutations.	Neuron	2014 Feb 5	Alami NH	doi: 10.1016/j.neuron.2013.12.018.
24464995	The crystal structure of TDP-43 RRM1-DNA complex reveals the specific recognition for UG- and TG-rich nucleic acids.	Nucleic Acids Res	2014 Apr	Kuo PH	doi: 10.1093/nar/gkt1407
27838743	Intrinsic disorder in proteins involved in amyotrophic lateral sclerosis.	Cell Mol Life Sci	2017 Apr	Santamaria N	doi: 10.1007/s00018-016-2416-6
18396105	TARDBP mutations in amyotrophic lateral sclerosis with TDP-43 neuropathology: a genetic and histopathological analysis.	Lancet Neurol	2008 May	Van Deerlin VM	doi: 10.1016/S1474-4422(08)70071-1
23118342	Muscleblind, BSF and TBPH are mislocalized in the muscle sarcomere of a Drosophila myotonic dystrophy model.	Dis Model Mech	2013 Jan	Llamusi B	doi: 10.1242/dmm.009563
23041957	How do the RNA-binding proteins TDP-43 and FUS relate to amyotrophic lateral sclerosis and frontotemporal degeneration, and to each other?	Curr Opin Neurol	2012 Dec	Baloh RH	doi: 10.1097/WCO.0b013e32835a269b.
22934129	Widespread binding of FUS along nascent RNA regulates alternative splicing in the brain.	Sci Rep	2012	Rogelj B	doi: 10.1038/srep00603
22127299	Gains or losses: molecular mechanisms of TDP43-mediated neurodegeneration.	Nat Rev Neurosci	2011 Nov 30	Lee EB	doi: 10.1038/nrn3121.
21956718	Conjoint pathologic cascades mediated by ALS/FTLD-U linked RNA-binding proteins TDP-43 and FUS.	Neurology	2011 Oct 25	Ito D	doi: 10.1212/WNL.0b013e3182343365
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28421535	MicroRNA Metabolism and Dysregulation in Amyotrophic Lateral Sclerosis.	Mol Neurobiol	2018 Mar	Rinchetti P	doi: 10.1007/s12035-017-0537-z
29279008	Comparative analysis of thermal unfolding simulations of RNA recognition motifs (RRMs) of TAR DNA-binding protein 43 (TDP-43).	J Biomol Struct Dyn	2019 Jan	Prakash A	doi: 10.1080/07391102.2017.1422026
29499929	Inhibition of TDP43-Mediated SNHG12-miR-195-SOX5 Feedback Loop Impeded Malignant Biological Behaviors of Glioma Cells.	Mol Ther Nucleic Acids	2018 Mar 2	Liu X	doi: 10.1016/j.omtn.2017.12.001
29577934	Selective Spatiotemporal Vulnerability of Central Nervous System Neurons to Pathologic TAR DNA-Binding Protein 43 in Aged Transgenic Mice.	Am J Pathol	2018 Jun	van Hummel A	doi: 10.1016/j.ajpath.2018.03.002
30774737	Molecular Mechanisms of Neurodegeneration Related to C9orf72 Hexanucleotide Repeat Expansion.	Behav Neurol	2019 Jan 15	Babic Leko M	doi: 10.1155/2019/2909168
7745706	Cloning and characterization of a novel cellular protein, TDP-43, that binds to human immunodeficiency virus type 1 TAR DNA sequence motifs.	J Virol	1995 Jun	Ou SH	-
11285240	Nuclear factor TDP-43 and SR proteins promote in vitro and in vivo CFTR exon 9 skipping.	EMBO J	2001 Apr 2	Buratti E	-
19539030	TDP-43 localizes in mRNA transcription and processing sites in mammalian neurons.	J Struct Biol	2009 Sep	Casafont I	doi: 10.1016/j.jsb.2009.06.006
19383787	Aberrant cleavage of TDP-43 enhances aggregation and cellular toxicity.	Proc Natl Acad Sci U S A	2009 May 5	Zhang YJ	doi: 10.1073/pnas.0900688106
22323604	TDP-43 promotes microRNA biogenesis as a component of the Drosha and Dicer complexes.	Proc Natl Acad Sci U S A	2012 Feb 28	Kawahara Y	doi: 10.1073/pnas.1112427109
21681666	TDP-43 autoregulation: implications for disease.	J Mol Neurosci	2011 Nov	Budini M	doi: 10.1007/s12031-011-9573-8
21173160	TDP-43 is directed to stress granules by sorbitol, a novel physiological osmotic and oxidative stressor.	Mol Cell Biol	2011 Mar	Dewey CM	doi: 10.1128/MCB.01279-10
20948999	Tar DNA binding protein-43 (TDP-43) associates with stress granules: analysis of cultured cells and pathological brain tissue.	PLoS One	2010 Oct 11	Liu-Yesucevitz L	doi: 10.1371/journal.pone.0013250.
20888804	Progranulin deficiency leads to enhanced cell vulnerability and TDP-43 translocation in primary neuronal cultures.	Brain Res	2010 Dec 17	Guo A	doi: 10.1016/j.brainres.2010.09.099
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26915990	TDP-43 binds and transports G-quadruplex-containing mRNAs into neurites for local translation.	Genes Cells	2016 May	Ishiguro A	doi: 10.1111/gtc.12352
26751167	CUL2-mediated clearance of misfolded TDP-43 is paradoxically affected by VHL in oligodendrocytes in ALS.	Sci Rep	2016 Jan 11	Uchida T	doi: 10.1038/srep19118.
27164932	Comparative interactomics analysis of different ALS-associated proteins identifies converging molecular pathways.	Acta Neuropathol	2016 Aug	Blokhuis AM	doi: 10.1007/s00401-016-1575-8
26219309	Rapamycin alleviates pathogenesis of a new Drosophila model of ALS-TDP.	J Neurogenet	2015	Cheng CW	doi: 10.3109/01677063.2015.1077832
26064939	Novel Mechanisms of Spinal Cord Plasticity in a Mouse Model of Motoneuron Disease.	Biomed Res Int	2015	Gulino R	doi: 10.1155/2015/654637
25845943	InSAC: A novel sub-nuclear body essential for Interleukin-6 and -10 RNA processing and stability.	BMB Rep	2015 May	Lee S	-
28466273	TDP-43 and Cytoskeletal Proteins in ALS.	Mol Neurobiol	2018 Apr	Oberstadt M	doi: 10.1007/s12035-017-0543-1
28472174	Augmented quantal release of acetylcholine at the vertebrate neuromuscular junction following tdp-43 depletion.	PLoS One	2017 May 4	Dzieciolowska S	doi: 10.1371/journal.pone.0177005
28497562	Different aggregation states of a nuclear localization signal-tagged 25-kDa C-terminal fragment of TAR RNA/DNA-binding protein 43kDa.	Genes Cells	2017 Jun	Kitamura A	doi: 10.1111/gtc.12495
28531192	Overexpression of the essential Sis1 chaperone reduces TDP-43 effects on toxicity and proteolysis.	PLoS Genet	2017 May 22	Park SK	doi: 10.1371/journal.pgen.1006805
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30770445	Motor neuron disease-associated loss of nuclear TDP-43 is linked to DNA double-strand break repair defects.	Proc Natl Acad Sci U S A	2019 Feb 15	Mitra J	doi: 10.1073/pnas.1818415116
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31259382	localizes to atherosclerotic lesions of human carotid and main cerebral arteries.	Histol Histopathol	2019 Jul 1:18140	Umahara T	doi: 10.14670/HH-18-140

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000315091	TARDBP-202	1835	-	ENSP00000313129	295 (aa)	-	B1AKP7
ENST00000477447	TARDBP-208	409	-	ENSP00000465888	65 (aa)	-	K7EL26
ENST00000639599	TARDBP-231	1283	-	ENSP00000492196	295 (aa)	-	B1AKP7
ENST00000613864	TARDBP-215	584	-	-	- (aa)	-	-
ENST00000619555	TARDBP-221	682	-	ENSP00000479978	138 (aa)	-	A0A087WW61
ENST00000480464	TARDBP-209	790	-	-	- (aa)	-	-
ENST00000473869	TARDBP-206	1946	-	ENSP00000432132	298 (aa)	-	G3V162
ENST00000614494	TARDBP-216	515	-	ENSP00000482754	78 (aa)	-	A0A087WZM1
ENST00000618606	TARDBP-220	584	-	-	- (aa)	-	-
ENST00000639083	TARDBP-230	2269	-	ENSP00000491203	414 (aa)	-	Q13148
ENST00000616545	TARDBP-217	920	-	ENSP00000484722	301 (aa)	-	A0A087X260
ENST00000476201	TARDBP-207	929	-	ENSP00000466842	275 (aa)	-	K7EN94
ENST00000473118	TARDBP-205	701	-	ENSP00000465240	201 (aa)	-	K7EJM5
ENST00000638264	TARDBP-229	774	-	ENSP00000491085	258 (aa)	-	A0A1W2PNU8
ENST00000496840	TARDBP-210	692	-	ENSP00000467020	16 (aa)	-	K7ENM9
ENST00000617757	TARDBP-219	434	-	-	- (aa)	-	-
ENST00000610369	TARDBP-211	563	-	ENSP00000482559	127 (aa)	-	A0A087WZC9
ENST00000439080	TARDBP-203	1388	-	ENSP00000404666	84 (aa)	-	A0A0A0MSV7
ENST00000622057	TARDBP-227	706	-	ENSP00000481206	200 (aa)	-	A0A087WXQ5
ENST00000240185	TARDBP-201	5367	XM_017000863	ENSP00000240185	414 (aa)	XP_016856352	Q13148
ENST00000620632	TARDBP-223	706	-	ENSP00000480771	149 (aa)	-	A0A087WX67
ENST00000621790	TARDBP-226	1008	-	ENSP00000482191	304 (aa)	-	A0A087WYY0
ENST00000611008	TARDBP-212	929	-	-	- (aa)	-	-
ENST00000649624	TARDBP-232	810	-	ENSP00000497327	269 (aa)	-	A0A0A0N0M3
ENST00000613177	TARDBP-214	379	-	-	- (aa)	-	-
ENST00000620505	TARDBP-222	657	-	ENSP00000479758	115 (aa)	-	A0A087WVX6
ENST00000629725	TARDBP-228	1031	-	ENSP00000486989	298 (aa)	-	G3V162
ENST00000472476	TARDBP-204	1001	-	ENSP00000465080	80 (aa)	-	K7EJ99
ENST00000611963	TARDBP-213	739	-	ENSP00000481330	175 (aa)	-	A0A087WXV3
ENST00000621715	TARDBP-225	816	-	ENSP00000480690	243 (aa)	-	A0A087WX29
ENST00000617172	TARDBP-218	980	-	ENSP00000479219	212 (aa)	-	A0A087WV68
ENST00000621573	TARDBP-224	992	-	ENSP00000477852	35 (aa)	-	A0A087WTG4

Gene Model

Click here to download 's gene model file

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000120948	rs34247753	1	11014942	C	Male-pattern baldness	28196072	NR unit increase	0.0482657	Orphanet_79364

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000120948's network

Paralog

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy
ENSG00000120948	TARDBP	77	38.194	ENSG00000138668	HNRNPD	99	43.363
ENSG00000120948	TARDBP	77	30.556	ENSG00000066044	ELAVL1	59	30.556
ENSG00000120948	TARDBP	80	34.921	ENSG00000170144	HNRNPA3	91	30.699
ENSG00000120948	TARDBP	92	31.507	ENSG00000153944	MSI2	88	31.507
ENSG00000120948	TARDBP	77	32.075	ENSG00000152795	HNRNPDL	61	34.746
ENSG00000120948	TARDBP	85	31.073	ENSG00000197451	HNRNPAB	75	30.275
ENSG00000120948	TARDBP	63	42.593	ENSG00000135486	HNRNPA1	96	37.615
ENSG00000120948	TARDBP	91	30.208	ENSG00000122566	HNRNPA2B1	77	32.886
ENSG00000120948	TARDBP	53	31.579	ENSG00000107105	ELAVL2	88	31.579
ENSG00000120948	TARDBP	94	32.184	ENSG00000071626	DAZAP1	55	33.862
ENSG00000120948	TARDBP	82	32.026	ENSG00000139675	HNRNPA1L2	60	32.812

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy	Species
ENSG00000120948	TARDBP	99	86.250	ENSAPOG00000012879	tardbpl	97	80.277	Acanthochromis_polyacanthus
ENSG00000120948	TARDBP	99	86.869	ENSAPOG00000002526	tardbp	99	73.301	Acanthochromis_polyacanthus
ENSG00000120948	TARDBP	100	99.005	ENSAMEG00000009476	TARDBP	100	97.585	Ailuropoda_melanoleuca
ENSG00000120948	TARDBP	100	70.149	ENSAMEG00000008772	-	100	69.888	Ailuropoda_melanoleuca
ENSG00000120948	TARDBP	99	86.869	ENSACIG00000009109	tardbp	99	72.816	Amphilophus_citrinellus
ENSG00000120948	TARDBP	100	82.673	ENSACIG00000003327	tardbpl	100	69.431	Amphilophus_citrinellus
ENSG00000120948	TARDBP	99	86.250	ENSAOCG00000020211	tardbpl	97	79.931	Amphiprion_ocellaris
ENSG00000120948	TARDBP	99	86.869	ENSAOCG00000002631	tardbp	99	72.816	Amphiprion_ocellaris
ENSG00000120948	TARDBP	99	86.250	ENSAPEG00000018093	tardbpl	97	79.931	Amphiprion_percula
ENSG00000120948	TARDBP	99	86.869	ENSAPEG00000002615	tardbp	99	72.816	Amphiprion_percula
ENSG00000120948	TARDBP	100	84.653	ENSATEG00000017658	tardbpl	98	79.110	Anabas_testudineus
ENSG00000120948	TARDBP	99	86.869	ENSATEG00000024840	tardbp	99	72.816	Anabas_testudineus
ENSG00000120948	TARDBP	99	98.734	ENSAPLG00000006001	TARDBP	100	94.928	Anas_platyrhynchos
ENSG00000120948	TARDBP	96	81.347	ENSANAG00000027281	-	99	84.878	Aotus_nancymaae
ENSG00000120948	TARDBP	100	99.005	ENSANAG00000035249	-	100	98.792	Aotus_nancymaae
ENSG00000120948	TARDBP	99	86.869	ENSACLG00000013961	tardbp	99	72.816	Astatotilapia_calliptera
ENSG00000120948	TARDBP	100	81.683	ENSACLG00000025494	tardbpl	97	77.509	Astatotilapia_calliptera
ENSG00000120948	TARDBP	99	87.500	ENSAMXG00000030795	tardbpl	95	80.623	Astyanax_mexicanus
ENSG00000120948	TARDBP	99	85.000	ENSAMXG00000039549	tardbp	99	69.305	Astyanax_mexicanus
ENSG00000120948	TARDBP	99	100.000	ENSBTAG00000003697	TARDBP	100	97.585	Bos_taurus
ENSG00000120948	TARDBP	99	39.823	WBGene00006514	tdp-1	73	38.816	Caenorhabditis_elegans
ENSG00000120948	TARDBP	100	99.005	ENSCJAG00000002381	TARDBP	100	98.792	Callithrix_jacchus
ENSG00000120948	TARDBP	100	99.005	ENSCAFG00000016759	TARDBP	100	97.826	Canis_familiaris
ENSG00000120948	TARDBP	100	99.005	ENSCAFG00020002258	-	100	97.826	Canis_lupus_dingo
ENSG00000120948	TARDBP	97	100.000	ENSCAFG00020013548	-	100	76.952	Canis_lupus_dingo
ENSG00000120948	TARDBP	99	100.000	ENSCHIG00000026090	TARDBP	100	97.585	Capra_hircus
ENSG00000120948	TARDBP	99	100.000	ENSTSYG00000004077	TARDBP	100	97.101	Carlito_syrichta
ENSG00000120948	TARDBP	100	99.005	ENSCAPG00000015189	TARDBP	100	97.585	Cavia_aperea
ENSG00000120948	TARDBP	100	99.005	ENSCPOG00000011619	TARDBP	100	97.585	Cavia_porcellus
ENSG00000120948	TARDBP	100	99.005	ENSCCAG00000025859	-	100	98.792	Cebus_capucinus
ENSG00000120948	TARDBP	97	88.235	ENSCCAG00000034419	-	97	79.184	Cebus_capucinus
ENSG00000120948	TARDBP	99	96.491	ENSCCAG00000010279	-	100	85.956	Cebus_capucinus
ENSG00000120948	TARDBP	97	97.059	ENSCATG00000029126	-	100	72.705	Cercocebus_atys
ENSG00000120948	TARDBP	99	100.000	ENSCATG00000031367	TARDBP	100	95.894	Cercocebus_atys
ENSG00000120948	TARDBP	100	99.005	ENSCLAG00000014547	TARDBP	100	97.368	Chinchilla_lanigera
ENSG00000120948	TARDBP	100	99.517	ENSCSAG00000019136	-	100	99.517	Chlorocebus_sabaeus
ENSG00000120948	TARDBP	100	100.000	ENSCSAG00000000785	-	100	99.758	Chlorocebus_sabaeus
ENSG00000120948	TARDBP	99	100.000	ENSCHOG00000013276	-	98	80.165	Choloepus_hoffmanni
ENSG00000120948	TARDBP	100	99.005	ENSCPBG00000022012	TARDBP	100	96.135	Chrysemys_picta_bellii
ENSG00000120948	TARDBP	95	59.459	ENSCING00000000050	tardbp	62	57.091	Ciona_intestinalis
ENSG00000120948	TARDBP	97	53.947	ENSCSAVG00000008831	-	65	55.088	Ciona_savignyi
ENSG00000120948	TARDBP	100	100.000	ENSCANG00000030022	TARDBP	100	100.000	Colobus_angolensis_palliatus
ENSG00000120948	TARDBP	99	77.889	ENSCANG00000023420	-	91	66.586	Colobus_angolensis_palliatus
ENSG00000120948	TARDBP	99	93.671	ENSCGRG00001015454	-	100	68.116	Cricetulus_griseus_chok1gshd
ENSG00000120948	TARDBP	100	99.005	ENSCGRG00001010684	-	100	96.382	Cricetulus_griseus_chok1gshd
ENSG00000120948	TARDBP	100	99.005	ENSCGRG00000007923	-	100	96.309	Cricetulus_griseus_crigri
ENSG00000120948	TARDBP	99	93.671	ENSCGRG00000002018	-	100	68.116	Cricetulus_griseus_crigri
ENSG00000120948	TARDBP	99	85.000	ENSCSEG00000005274	tardbpl	93	80.427	Cynoglossus_semilaevis
ENSG00000120948	TARDBP	99	83.838	ENSCSEG00000021744	tardbp	99	69.417	Cynoglossus_semilaevis
ENSG00000120948	TARDBP	99	86.364	ENSCVAG00000006178	tardbp	99	74.515	Cyprinodon_variegatus
ENSG00000120948	TARDBP	99	86.250	ENSCVAG00000016647	tardbpl	98	80.623	Cyprinodon_variegatus
ENSG00000120948	TARDBP	99	85.000	ENSDARG00000040031	tardbp	99	69.585	Danio_rerio
ENSG00000120948	TARDBP	99	86.364	ENSDARG00000004452	tardbpl	95	81.164	Danio_rerio
ENSG00000120948	TARDBP	100	98.507	ENSDNOG00000008531	TARDBP	100	96.860	Dasypus_novemcinctus
ENSG00000120948	TARDBP	99	100.000	ENSDORG00000007465	Tardbp	100	96.618	Dipodomys_ordii
ENSG00000120948	TARDBP	86	73.134	FBgn0025790	TBPH	86	57.093	Drosophila_melanogaster
ENSG00000120948	TARDBP	87	67.647	FBgn0036496	CG7804	84	54.074	Drosophila_melanogaster
ENSG00000120948	TARDBP	99	96.491	ENSETEG00000004358	TARDBP	100	96.108	Echinops_telfairi
ENSG00000120948	TARDBP	95	64.865	ENSEBUG00000000353	-	84	45.625	Eptatretus_burgeri
ENSG00000120948	TARDBP	97	81.250	ENSEBUG00000015638	tardbpl	84	58.099	Eptatretus_burgeri
ENSG00000120948	TARDBP	94	65.753	ENSEBUG00000007562	-	88	56.098	Eptatretus_burgeri
ENSG00000120948	TARDBP	100	99.005	ENSEASG00005019017	TARDBP	100	97.585	Equus_asinus_asinus
ENSG00000120948	TARDBP	100	99.005	ENSECAG00000008338	TARDBP	100	97.585	Equus_caballus
ENSG00000120948	TARDBP	99	99.123	ENSEEUG00000003755	TARDBP	100	97.101	Erinaceus_europaeus
ENSG00000120948	TARDBP	99	86.869	ENSELUG00000009090	tardbp	99	72.573	Esox_lucius
ENSG00000120948	TARDBP	99	87.500	ENSELUG00000013252	tardbpl	95	79.110	Esox_lucius
ENSG00000120948	TARDBP	92	81.944	ENSFCAG00000040067	-	97	83.237	Felis_catus
ENSG00000120948	TARDBP	100	99.005	ENSFCAG00000000050	TARDBP	100	97.585	Felis_catus
ENSG00000120948	TARDBP	100	98.010	ENSFALG00000007199	TARDBP	99	93.961	Ficedula_albicollis
ENSG00000120948	TARDBP	100	99.005	ENSFDAG00000004675	TARDBP	100	97.585	Fukomys_damarensis
ENSG00000120948	TARDBP	99	86.364	ENSFHEG00000019998	tardbp	99	72.816	Fundulus_heteroclitus
ENSG00000120948	TARDBP	99	86.250	ENSFHEG00000010145	tardbpl	97	80.623	Fundulus_heteroclitus
ENSG00000120948	TARDBP	100	85.185	ENSGMOG00000016367	tardbp	99	69.617	Gadus_morhua
ENSG00000120948	TARDBP	99	86.250	ENSGMOG00000000526	tardbpl	91	84.133	Gadus_morhua
ENSG00000120948	TARDBP	100	98.010	ENSGALG00000002906	TARDBP	100	95.411	Gallus_gallus
ENSG00000120948	TARDBP	99	86.250	ENSGAFG00000019234	tardbpl	100	69.596	Gambusia_affinis
ENSG00000120948	TARDBP	99	86.364	ENSGAFG00000011052	tardbp	99	72.816	Gambusia_affinis
ENSG00000120948	TARDBP	99	85.354	ENSGACG00000012164	tardbp	99	73.544	Gasterosteus_aculeatus
ENSG00000120948	TARDBP	100	84.653	ENSGACG00000007124	tardbpl	97	80.277	Gasterosteus_aculeatus
ENSG00000120948	TARDBP	100	99.005	ENSGAGG00000009283	TARDBP	100	95.894	Gopherus_agassizii
ENSG00000120948	TARDBP	97	82.895	ENSGGOG00000042352	-	100	63.123	Gorilla_gorilla
ENSG00000120948	TARDBP	97	100.000	ENSGGOG00000028580	-	100	73.864	Gorilla_gorilla
ENSG00000120948	TARDBP	99	100.000	ENSGGOG00000015357	-	82	100.000	Gorilla_gorilla
ENSG00000120948	TARDBP	99	86.869	ENSHBUG00000002328	tardbp	99	72.816	Haplochromis_burtoni
ENSG00000120948	TARDBP	100	81.683	ENSHBUG00000020551	tardbpl	97	77.509	Haplochromis_burtoni
ENSG00000120948	TARDBP	99	81.013	ENSHGLG00000008540	-	100	87.970	Heterocephalus_glaber_female
ENSG00000120948	TARDBP	100	98.507	ENSHGLG00000018967	TARDBP	100	97.585	Heterocephalus_glaber_female
ENSG00000120948	TARDBP	100	98.507	ENSHGLG00100014781	TARDBP	100	97.585	Heterocephalus_glaber_male
ENSG00000120948	TARDBP	100	87.562	ENSHGLG00100006769	-	100	86.715	Heterocephalus_glaber_male
ENSG00000120948	TARDBP	100	85.644	ENSHCOG00000015858	tardbpl	99	80.969	Hippocampus_comes
ENSG00000120948	TARDBP	95	89.189	ENSHCOG00000002224	tardbp	99	71.325	Hippocampus_comes
ENSG00000120948	TARDBP	99	85.222	ENSIPUG00000004992	tardbp	95	80.969	Ictalurus_punctatus
ENSG00000120948	TARDBP	99	83.085	ENSIPUG00000023818	TARDBP	99	68.675	Ictalurus_punctatus
ENSG00000120948	TARDBP	100	98.507	ENSSTOG00000008406	-	100	97.101	Ictidomys_tridecemlineatus
ENSG00000120948	TARDBP	99	99.123	ENSSTOG00000021089	-	100	92.271	Ictidomys_tridecemlineatus
ENSG00000120948	TARDBP	99	100.000	ENSJJAG00000014196	-	100	95.932	Jaculus_jaculus
ENSG00000120948	TARDBP	100	84.158	ENSKMAG00000015796	tardbpl	97	79.585	Kryptolebias_marmoratus
ENSG00000120948	TARDBP	99	86.869	ENSKMAG00000005913	tardbp	86	73.301	Kryptolebias_marmoratus
ENSG00000120948	TARDBP	99	86.364	ENSLBEG00000022827	tardbp	97	81.695	Labrus_bergylta
ENSG00000120948	TARDBP	99	85.000	ENSLBEG00000021801	tardbpl	98	78.498	Labrus_bergylta
ENSG00000120948	TARDBP	100	90.547	ENSLACG00000017101	TARDBP	100	81.687	Latimeria_chalumnae
ENSG00000120948	TARDBP	99	90.909	ENSLOCG00000006604	tardbpl	99	78.935	Lepisosteus_oculatus
ENSG00000120948	TARDBP	100	99.005	ENSLAFG00000014421	TARDBP	100	97.585	Loxodonta_africana
ENSG00000120948	TARDBP	99	84.810	ENSMFAG00000000832	-	100	84.772	Macaca_fascicularis
ENSG00000120948	TARDBP	100	100.000	ENSMFAG00000002750	TARDBP	100	100.000	Macaca_fascicularis
ENSG00000120948	TARDBP	100	100.000	ENSMMUG00000007456	TARDBP	100	100.000	Macaca_mulatta
ENSG00000120948	TARDBP	100	84.080	ENSMMUG00000003940	-	99	82.353	Macaca_mulatta
ENSG00000120948	TARDBP	99	90.351	ENSMNEG00000025649	-	100	76.570	Macaca_nemestrina
ENSG00000120948	TARDBP	100	100.000	ENSMNEG00000030163	TARDBP	100	100.000	Macaca_nemestrina
ENSG00000120948	TARDBP	100	99.661	ENSMLEG00000041791	TARDBP	100	99.661	Mandrillus_leucophaeus
ENSG00000120948	TARDBP	99	86.250	ENSMAMG00000009233	tardbpl	97	78.893	Mastacembelus_armatus
ENSG00000120948	TARDBP	99	86.869	ENSMAMG00000016626	tardbp	99	72.816	Mastacembelus_armatus
ENSG00000120948	TARDBP	99	86.869	ENSMZEG00005014992	tardbp	99	72.816	Maylandia_zebra
ENSG00000120948	TARDBP	100	81.683	ENSMZEG00005013608	tardbpl	97	77.509	Maylandia_zebra
ENSG00000120948	TARDBP	100	98.010	ENSMGAG00000004637	TARDBP	100	95.411	Meleagris_gallopavo
ENSG00000120948	TARDBP	99	100.000	ENSMAUG00000018057	Tardbp	100	95.973	Mesocricetus_auratus
ENSG00000120948	TARDBP	99	100.000	ENSMICG00000003838	TARDBP	100	95.652	Microcebus_murinus
ENSG00000120948	TARDBP	100	99.005	ENSMOCG00000003562	Tardbp	100	96.309	Microtus_ochrogaster
ENSG00000120948	TARDBP	99	86.364	ENSMMOG00000011034	tardbp	99	72.816	Mola_mola
ENSG00000120948	TARDBP	99	85.000	ENSMMOG00000009189	tardbpl	100	70.024	Mola_mola
ENSG00000120948	TARDBP	100	99.005	ENSMODG00000011233	-	100	97.315	Monodelphis_domestica
ENSG00000120948	TARDBP	99	83.544	ENSMODG00000000892	-	100	73.966	Monodelphis_domestica
ENSG00000120948	TARDBP	99	87.374	ENSMALG00000001764	tardbp	99	73.058	Monopterus_albus
ENSG00000120948	TARDBP	100	84.158	ENSMALG00000021161	tardbpl	97	78.893	Monopterus_albus
ENSG00000120948	TARDBP	100	99.177	MGP_CAROLIEiJ_G0026805	Tardbp	100	99.329	Mus_caroli
ENSG00000120948	TARDBP	100	99.177	ENSMUSG00000041459	Tardbp	100	99.329	Mus_musculus
ENSG00000120948	TARDBP	99	100.000	MGP_PahariEiJ_G0029153	Tardbp	100	98.765	Mus_pahari
ENSG00000120948	TARDBP	100	99.177	MGP_SPRETEiJ_G0027798	Tardbp	100	99.329	Mus_spretus
ENSG00000120948	TARDBP	100	99.005	ENSMPUG00000016443	TARDBP	100	97.315	Mustela_putorius_furo
ENSG00000120948	TARDBP	100	99.005	ENSMLUG00000004263	TARDBP	100	97.101	Myotis_lucifugus
ENSG00000120948	TARDBP	100	77.114	ENSNGAG00000011442	-	97	73.219	Nannospalax_galili
ENSG00000120948	TARDBP	100	99.005	ENSNGAG00000023416	-	100	97.288	Nannospalax_galili
ENSG00000120948	TARDBP	100	81.683	ENSNBRG00000006706	tardbpl	97	77.509	Neolamprologus_brichardi
ENSG00000120948	TARDBP	99	85.572	ENSNBRG00000019066	tardbp	99	72.289	Neolamprologus_brichardi
ENSG00000120948	TARDBP	96	97.333	ENSNLEG00000026620	-	92	94.574	Nomascus_leucogenys
ENSG00000120948	TARDBP	99	94.937	ENSNLEG00000027732	-	90	72.890	Nomascus_leucogenys
ENSG00000120948	TARDBP	100	100.000	ENSNLEG00000009512	TARDBP	100	100.000	Nomascus_leucogenys
ENSG00000120948	TARDBP	100	99.005	ENSMEUG00000006548	TARDBP	100	97.368	Notamacropus_eugenii
ENSG00000120948	TARDBP	100	97.512	ENSOPRG00000006352	TARDBP	100	96.860	Ochotona_princeps
ENSG00000120948	TARDBP	99	91.139	ENSODEG00000002855	-	100	70.433	Octodon_degus
ENSG00000120948	TARDBP	99	77.215	ENSODEG00000006114	-	95	66.496	Octodon_degus
ENSG00000120948	TARDBP	99	100.000	ENSODEG00000013739	-	100	100.000	Octodon_degus
ENSG00000120948	TARDBP	100	82.178	ENSONIG00000002332	tardbpl	97	77.855	Oreochromis_niloticus
ENSG00000120948	TARDBP	99	84.729	ENSONIG00000004027	tardbp	99	71.942	Oreochromis_niloticus
ENSG00000120948	TARDBP	100	99.005	ENSOANG00000013320	TARDBP	100	97.585	Ornithorhynchus_anatinus
ENSG00000120948	TARDBP	92	90.278	ENSOCUG00000004049	-	100	90.521	Oryctolagus_cuniculus
ENSG00000120948	TARDBP	99	86.869	ENSORLG00000003593	tardbp	99	73.301	Oryzias_latipes
ENSG00000120948	TARDBP	99	86.250	ENSORLG00000005188	tardbpl	97	80.690	Oryzias_latipes
ENSG00000120948	TARDBP	99	86.869	ENSORLG00020021206	tardbp	99	73.544	Oryzias_latipes_hni
ENSG00000120948	TARDBP	99	86.250	ENSORLG00020013159	tardbpl	97	80.690	Oryzias_latipes_hni
ENSG00000120948	TARDBP	99	86.869	ENSORLG00015017343	tardbp	99	72.816	Oryzias_latipes_hsok
ENSG00000120948	TARDBP	99	86.250	ENSORLG00015005048	tardbpl	97	80.690	Oryzias_latipes_hsok
ENSG00000120948	TARDBP	99	86.869	ENSOMEG00000000997	tardbp	99	73.058	Oryzias_melastigma
ENSG00000120948	TARDBP	99	86.250	ENSOMEG00000003102	tardbpl	97	80.345	Oryzias_melastigma
ENSG00000120948	TARDBP	99	100.000	ENSOGAG00000016721	TARDBP	100	87.500	Otolemur_garnettii
ENSG00000120948	TARDBP	94	74.615	ENSOARG00000020974	-	100	66.522	Ovis_aries
ENSG00000120948	TARDBP	99	98.246	ENSOARG00000010657	-	100	96.418	Ovis_aries
ENSG00000120948	TARDBP	99	100.000	ENSOARG00000004268	-	100	96.386	Ovis_aries
ENSG00000120948	TARDBP	97	100.000	ENSPPAG00000024941	-	100	76.154	Pan_paniscus
ENSG00000120948	TARDBP	100	100.000	ENSPPAG00000039086	TARDBP	100	100.000	Pan_paniscus
ENSG00000120948	TARDBP	100	99.005	ENSPPRG00000003255	TARDBP	100	97.585	Panthera_pardus
ENSG00000120948	TARDBP	100	80.100	ENSPTIG00000014945	-	99	76.042	Panthera_tigris_altaica
ENSG00000120948	TARDBP	100	99.005	ENSPTIG00000011396	TARDBP	100	97.585	Panthera_tigris_altaica
ENSG00000120948	TARDBP	100	100.000	ENSPTRG00000048576	-	100	100.000	Pan_troglodytes
ENSG00000120948	TARDBP	88	95.714	ENSPTRG00000052781	-	98	83.936	Pan_troglodytes
ENSG00000120948	TARDBP	100	100.000	ENSPTRG00000000136	TARDBP	100	100.000	Pan_troglodytes
ENSG00000120948	TARDBP	97	100.000	ENSPTRG00000049552	-	100	75.000	Pan_troglodytes
ENSG00000120948	TARDBP	100	100.000	ENSPANG00000017459	TARDBP	100	100.000	Papio_anubis
ENSG00000120948	TARDBP	99	89.394	ENSPKIG00000012179	tardbp	99	76.029	Paramormyrops_kingsleyae
ENSG00000120948	TARDBP	100

EuRBPDB

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Cell lines and drugs in GSE70138 or GSE92742

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Cell lines and drugs in GSE70138 or GSE92742

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