EuRBPDB

  • Home
  • Cancer
  • Family
  • Species
  • RBPredictor
  • Search
  • Download
  • Submit
  • Help
  • Contact
TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
27819670HSP110 promotes colorectal cancer growth through STAT3 activation.Oncogene2017 Apr 20Berthenet Kdoi: 10.1038/onc.2016.403
19476517Expression of heat shock protein 105 and 70 in malignant melanoma and benign melanocytic nevi.J Cutan Pathol2009 MayPark HSdoi: 10.1111/j.1600-0560.2008.01085.x
24512910Patients with colorectal tumors with microsatellite instability and large deletions in HSP110 T17 have improved response to 5-fluorouracil?Cbased chemotherapy.Gastroenterology2014 FebCollura A-
29204054Nuclear heat shock protein 110 expression is associated with poor prognosis and hyperthermo-chemotherapy resistance in gastric cancer patients with peritoneal metastasis.World J Gastroenterol2017 Nov 14Kimura Adoi: 10.3748/wjg.v23.i42.7541.

Differential Expression

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
BLCAchr1331151625Missense_MutationnovelN216S0.53
BLCAchr1331155552Missense_Mutationrs775598360D90N0.32
BLCAchr1331138457Missense_MutationnovelL774F0.1
BLCAchr1331152898Missense_MutationNAQ161H0.3
BLCAchr1331154663Silentrs111995920L133L0.24
BLCAchr1331149992Missense_MutationnovelN367Y0.03
BLCAchr1331151165Missense_Mutationrs143448335F230L0.08
BLCAchr1331151160Missense_MutationnovelG232A0.16
BLCAchr1331137449Missense_MutationnovelP816A0.22
BRCAchr1331148058Missense_MutationNAP427S0.33
BRCAchr1331140301Missense_MutationNAM621I0.34
BRCAchr13311373173'UTRnovel0.28
BRCAchr1331145733Missense_MutationNAD472H0.25
BRCAchr1331150020Missense_MutationNAF357L0.16
CESCchr1331151660SilentNAG204G0.17
CESCchr13311622825'Flanknovel0.56
CESCchr1331150061Missense_MutationNAA344T0.32
CESCchr1331138423Missense_MutationnovelI785T0.07
CESCchr1331143847Missense_MutationNAS554C0.29
COADchr1331137340Missense_Mutationrs771770114S852Y0.43
COADchr1331148462Missense_MutationnovelA386T0.52
COADchr1331138876Missense_MutationnovelR705W0.09
COADchr1331151116Nonsense_MutationnovelE247*0.4
COADchr1331161571SilentnovelV4V0.25
COADchr1331145699Missense_Mutationrs765642778R483Q0.34
COADchr13311370193'UTRnovel0.21
COADchr1331158837Frame_Shift_DelNAN45Ifs*430.23
COADchr1331148404Missense_MutationNAI405N0.18
COADchr1331151147Silentrs146776431F236F0.34
COADchr1331158837Frame_Shift_DelNAN45Ifs*430.45
COADchr1331161518Frame_Shift_DelNAG22Afs*660.43
ESCAchr1331155532Frame_Shift_InsnovelN96Kfs*130.27
ESCAchr1331147990SilentnovelP449P0.13
GBMchr1331148473Missense_MutationnovelI382K0.38
GBMchr13311370933'UTRrs7727806290.25
GBMchr1331137340Missense_MutationNAS852F0.23
GBMchr1331148043Missense_MutationnovelL432F0.31
GBMchr1331139002Missense_Mutationrs548315411M696L0.32
HNSCchr1331137510Silentrs749769750T795T0.52
HNSCchr1331137418Missense_MutationnovelE826G0.28
HNSCchr1331150975Missense_MutationnovelD294H0.05
HNSCchr13311370563'UTRnovel0.22
HNSCchr1331148014SilentnovelE441E0.09
HNSCchr1331148011SilentnovelL442L0.23
HNSCchr1331154714SilentnovelQ116Q0.31
HNSCchr1331138891Missense_MutationnovelT700S0.54
HNSCchr1331137500Missense_MutationnovelV799F0.28
KIRCchr1331155568Missense_MutationNAK84N0.24
KIRCchr1331138538Missense_MutationNAE747K0.09
KIRPchr1331148044Frame_Shift_DelnovelL432Sfs*40.16
KIRPchr13311370043'UTRnovel0.08
KIRPchr1331154715Missense_MutationnovelQ116R0.49
LAMLchr1331143802Missense_MutationnovelD569G0.06
LAMLchr1331143840SilentnovelP556P0.08
LGGchr13311372743'UTRnovel0.43
LGGchr1331150991Silentrs144091980I288I0.29
LIHCchr1331141159Nonsense_MutationNAL606*0.5
LIHCchr1331149967Missense_MutationnovelG375V0.82
LIHCchr13311616425'UTRnovel0.41
LUADchr1331138894Missense_MutationnovelG699S0.5
LUADchr1331150084Missense_MutationNAS336I0.58
LUADchr1331138874SilentnovelR705R0.25
LUADchr1331138531Missense_MutationnovelK749T0.4
LUADchr1331145596SilentNAL517L0.11
LUADchr1331138858Missense_MutationnovelE711K0.33
LUADchr1331152891Missense_MutationnovelG164R0.07
LUADchr1331155561SilentnovelL87L0.13
LUADchr1331138864Missense_MutationNAA709T0.08
LUADchr1331137329Missense_MutationNAD856Y0.15
LUADchr1331161523SilentnovelA20A0.33
LUADchr1331161577Silentrs758077929S2S0.11
LUADchr1331138451Nonsense_MutationnovelQ776*0.15
LUADchr1331151024Missense_MutationNAM277I0.42
LUADchr1331138515SilentnovelS754S0.16
LUADchr1331150011Missense_MutationNAK360N0.18
LUSCchr13311371143'UTRnovel0.27
LUSCchr1331137502Missense_MutationnovelP798L0.45
LUSCchr13311372953'UTRnovel0.28
LUSCchr1331148378Missense_MutationnovelE414K0.13
LUSCchr1331154474Intronnovel0.38
LUSCchr1331140248Missense_MutationnovelE639G0.63
LUSCchr13311371413'UTRnovel0.11
OVchr1331152861Missense_MutationNAM174L0.24
OVchr1331139091Missense_MutationnovelL666W0.18
OVchr13311616235'UTRnovel0.08
OVchr1331151069SilentnovelA262A0.15
OVchr13311369413'UTRnovel0.32
PAADchr1331150104Missense_MutationnovelH329Q0.05
PRADchr1331152934SilentnovelT149T0.22
PRADchr1331161563Missense_MutationnovelD7G0.06
READchr1331151686Missense_MutationNAR196W0.12
READchr1331154585Intronnovel0.09
READchr1331152879SilentnovelL168L0.09
READchr1331137486Silentrs200201980P803P0.3
SARCchr1331151727Missense_MutationnovelG182E0.22
SARCchr1331151728Missense_MutationnovelG182R0.22
SARCchr13311620745'Flanknovel0.25
SKCMchr1331137330Missense_MutationNAM855I0.1
SKCMchr1331148464Missense_Mutationrs748889774P385L0.32
SKCMchr1331141186Missense_MutationNAP597L0.21
SKCMchr1331148424SilentNAV398V0.07
SKCMchr1331143806Missense_MutationNAP568S0.14
SKCMchr1331148025Missense_MutationNAG438R0.45
SKCMchr1331143918Missense_MutationnovelN530K0.38
SKCMchr1331137441SilentNAG818G0.4
SKCMchr13311372963'UTRnovel0.26
SKCMchr1331138837Missense_MutationnovelE718K0.5
SKCMchr13311372963'UTRnovel0.58
SKCMchr1331137340Missense_MutationNAS852F0.12
SKCMchr1331155609Missense_MutationnovelH71Y0.07
SKCMchr1331148467Missense_MutationNAS384F0.25
STADchr1331139062Silentrs527818681L676L0.08
STADchr1331150961Silentrs749589942S298S0.11
STADchr1331155627Missense_MutationNAS65T0.25
STADchr1331138516Missense_MutationNAS754Y0.27
STADchr1331150050SilentnovelI347I0.37
STADchr1331143867SilentNAD547D0.3
STADchr1331137518Missense_MutationNAN793D0.13
STADchr1331151654SilentNAS206S0.47
STADchr1331143861Silentrs752487587Q549Q0.06
STADchr1331141186Missense_MutationNAP597L0.15
STADchr1331141190SilentnovelL596L0.3
STADchr1331155553Silentrs575501640Y89Y0.39
STADchr1331145694Missense_MutationNAN485D0.18
STADchr1331137487Missense_MutationNAP803L0.35
STADchr1331158817Missense_MutationNAA52T0.28
THCAchr1331151089Missense_MutationNAA256S0.35
THCAchr1331154579IntronNA0.26
UCECchr1331145666Missense_Mutationrs765918581T494M0.15
UCECchr1331151147Silentrs146776431F236F0.33
UCECchr1331145628Nonsense_MutationNAE507*0.35
UCECchr1331139084SilentnovelL668L0.41
UCECchr1331141244Frame_Shift_Insrs763056145V578Sfs*20.44
UCECchr1331145764SilentnovelR461R0.38
UCECchr1331137340Missense_Mutationrs771770114S852Y0.31
UCECchr1331150991Silentrs144091980I288I0.35
UCECchr1331137473Missense_MutationnovelE808K0.49
UCECchr1331150948Missense_MutationnovelR303G0.4
UCECchr1331137486Silentrs200201980P803P0.3
UCECchr1331151147Silentrs146776431F236F0.36
UCECchr1331141131Missense_MutationnovelI615M0.36
UCECchr13311620535'Flanknovel0.11
UCECchr1331138443SilentnovelP778P0.46
UCECchr1331141237Missense_MutationnovelQ580R0.36
UCECchr1331151671Missense_MutationnovelV201I0.45
UCECchr13311620645'Flanknovel0.46
UCECchr13311372083'UTRnovel0.14
UCECchr1331137486Silentrs200201980P803P0.25
UCECchr1331141151Missense_MutationnovelD609Y0.36
UCECchr1331151618SilentnovelG218G0.43
UCECchr1331138560Missense_MutationNAK739N0.3
UCECchr1331148444Missense_MutationNAF392V0.12
UCECchr1331151074Nonsense_MutationNAR261*0.14
UCECchr1331154689SilentNAL125L0.18
UCECchr1331152947Missense_MutationnovelP145L0.21
UCECchr1331151074Nonsense_MutationNAR261*0.32
UCECchr1331150979Missense_MutationnovelM292I0.29
UCECchr1331137470Frame_Shift_InsnovelS809Nfs*300.05
UCECchr1331138875Missense_MutationNAR705Q0.4
UCECchr13311371823'UTRnovel0.29
UCECchr1331151147Silentrs146776431F236F0.5
UCECchr1331151732SilentnovelN180N0.16
UCECchr1331139102Missense_MutationnovelH662Q0.22
UCECchr1331145664Missense_MutationnovelA495T0.41
UCECchr1331148073Nonsense_MutationnovelR422*0.53
UCECchr13311619955'Flanknovel0.53
UCECchr1331147962Frame_Shift_DelnovelI459*0.12
UCECchr1331140197Missense_Mutationrs757280330F656C0.35
UCECchr1331138877SilentnovelV704V0.23
UCECchr13311367293'UTRnovel0.46
UCECchr1331145684Missense_MutationnovelG488D0.32
UCECchr13311621525'Flanknovel0.5
UCECchr1331150991Silentrs144091980I288I0.53
UCECchr1331151685Missense_MutationnovelR196Q0.41
UCECchr1331154533Intronnovel0.5
UCECchr13311620285'Flanknovel0.55
UCECchr1331148447Nonsense_MutationnovelE391*0.29
UCECchr1331140267Nonsense_MutationnovelD633Ifs*20.05
UCECchr1331151005Missense_MutationNAL284F0.36
UCECchr1331138892SilentnovelG699G0.17
UCECchr13311372833'UTRnovel0.33
UCECchr1331140197Missense_Mutationrs757280330F656C0.44
UCECchr1331150950Missense_MutationnovelN302S0.56
UCECchr1331151686Missense_MutationNAR196W0.67
UCECchr1331145713SilentnovelV478V0.08
UCECchr1331139050Missense_MutationnovelG680R0.22
UCECchr1331148471Missense_MutationnovelL383F0.41
UCECchr13311371003'UTRnovel0.38
UCECchr1331138521Missense_MutationnovelE752D0.42
UCECchr1331138845Frame_Shift_InsnovelM715Nfs*30.33
UCECchr1331141216Missense_MutationnovelP587L0.46
UCECchr1331150126Missense_MutationnovelY322C0.28
UCECchr13311371753'UTRnovel0.29
UCECchr1331139104Missense_MutationnovelH662N0.75
UCECchr1331137486Silentrs200201980P803P0.47
UCECchr1331148447Nonsense_MutationnovelE391*0.37
UCECchr1331150991Silentrs144091980I288I0.41
UCECchr1331140196Missense_MutationNAF656L0.35
UCECchr1331150969Missense_MutationnovelD296Y0.12
UCECchr13311371183'UTRnovel0.17
UCECchr1331148030Missense_MutationnovelR436I0.34
UCECchr1331151064Missense_MutationnovelL264P0.25
UCECchr1331151686Missense_MutationNAR196W0.36
UCECchr1331147962Frame_Shift_DelnovelI459*0.21
UCECchr1331151061Missense_MutationnovelR265H0.06
UCECchr13311370193'UTRnovel0.33
UCECchr1331155572Missense_MutationNAE83V0.05
UCECchr13311371773'UTRnovel0.46
UCECchr1331139095Missense_MutationNAF665V0.39
UCECchr1331145629SilentnovelN506N0.07
UCECchr1331137486Silentrs200201980P803P0.41
UCECchr1331143818Nonsense_MutationNAE564*0.2
UCECchr1331151074Nonsense_MutationNAR261*0.34
UCECchr13311372023'UTRnovel0.32
UCECchr1331151639SilentnovelS211S0.39
UCECchr1331150086SilentnovelV335V0.23
UCECchr1331161552Nonsense_MutationnovelQ11*0.57
UCECchr1331148419Missense_MutationnovelF400S0.31
UCECchr1331151686Missense_MutationNAR196W0.38
UCECchr1331152921Nonsense_MutationNAR154*0.26
UCSchr1331139099Missense_MutationnovelQ663H0.27
UCSchr1331140199Missense_MutationnovelK655N0.33

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
KIRCDEL0.12120.031318
MESODEL0.42530.0010209
STADAMP0.31070.01734
THCADEL0.02810.011063

Survival Analysis
CancerP-value Q-value
SARC0.015

Kaplan-Meier Survival Analysis

MESO0.021

Kaplan-Meier Survival Analysis

HNSC0.00068

Kaplan-Meier Survival Analysis

BRCA0.022

Kaplan-Meier Survival Analysis

ESCA0.0041

Kaplan-Meier Survival Analysis

KIRP0.012

Kaplan-Meier Survival Analysis

LAML0.039

Kaplan-Meier Survival Analysis

LIHC0.00018

Kaplan-Meier Survival Analysis

UVM0.004

Kaplan-Meier Survival Analysis

Drugs

Select Dataset :


Input Drug :


Input Cell Line :


Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBPome
  • Literatures
  • Expression
  • Transcripts
  • Gene Model
  • Pathways
  • Phenotypes
  • PPI
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000120694 (Gene tree)
Gene ID
10808
Gene Symbol
HSPH1
Alias
HSP105B|KIAA0201|HSP105A|NY-CO-25
Full Name
heat shock protein family H (Hsp110) member 1
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Minus strand
Length
28,136 bases
Position
chr13:31,134,974-31,163,109
Accession
16969
RBP type
non-canonical RBP
Summary
This gene encodes a member of the heat shock protein 70 family of proteins. The encoded protein functions as a nucleotide exchange factor for the molecular chaperone heat shock cognate 71 kDa protein (Hsc70). In addition, this protein plays a distinct but related role as a holdase that inhibits the aggregation of misfolded proteins, including the cystic fibrosis transmembrane conductance regulator (CFTR) protein. Elevated expression of this protein has been observed in numerous human cancers. [provided by RefSeq, Mar 2017]
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & HEK2932019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & HEK2932018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
29431736Capturing the interactome of newly transcribed RNAPolyT-RICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
29431736Capturing the interactome of newly transcribed RNARICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & Hela2018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & MCF10A2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & MCF72018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & U2OS2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
27491955Control of the heat stress-induced alternative splicing of a subset of genes by hnRNP K.Genes Cells2016 SepYamamoto Kdoi: 10.1111/gtc.12400
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000435381HSPH1-203812-ENSP00000408991115 (aa)-Q5TBM3
ENST00000469538HSPH1-205333--- (aa)--
ENST00000380405HSPH1-2023480XM_017020363ENSP00000369768814 (aa)XP_016875852Q92598
ENST00000320027HSPH1-2015191XM_011534888ENSP00000318687858 (aa)XP_011533190Q92598
ENST00000629751HSPH1-2081034--- (aa)--
ENST00000445273HSPH1-2044987-ENSP00000396090782 (aa)-A0A0A0MSM0
ENST00000630972HSPH1-2093570XM_005266236ENSP00000487365860 (aa)XP_005266293Q92598
ENST00000602786HSPH1-2063488-ENSP00000473512115 (aa)-R4GN69
ENST00000626866HSPH1-2074381--- (aa)--
Gene Model
Click here to download ENSG00000120694's gene model file
Pathways
Pathway IDPathway NameSource
hsa04141Protein processing in endoplasmic reticulumKEGG
Phenotypes
ensgIDTraitpValuePubmed ID
ENSG00000120694Body Mass Index3.56503472795922E-517903300
ENSG00000120694Body Mass Index4.803246198537E-517903300
ENSG00000120694Body Mass Index1.51841421764942E-517903300
ENSG00000120694Body Mass Index2.05343470423003E-517903300
ENSG00000120694Body Weight5.60146183385957E-517903300
ENSG00000120694Body Weight5.27716206515372E-517903300
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000120694's network

* RBP PPI network refers to all genes directly bind to RBP
Orthologs identified by RBPome
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000120694HSPH110093.497ENSMUSG00000029657Hsph110098.000Mus_musculus
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0000774adenyl-nucleotide exchange factor activity24318877.IDAFunction
GO:0005515protein binding17024176.23349634.24318877.25036637.IPIFunction
GO:0005524ATP binding-IEAFunction
GO:0005576extracellular region12952910.TASComponent
GO:0005634nucleus21873635.IBAComponent
GO:0005654nucleoplasm-IDAComponent
GO:0005737cytoplasm9931472.IDAComponent
GO:0005829cytosol21873635.IBAComponent
GO:0005829cytosol21231916.IDAComponent
GO:0005829cytosol-TASComponent
GO:0005874microtubule-IEAComponent
GO:0006898receptor-mediated endocytosis-TASProcess
GO:0006986response to unfolded protein9931472.TASProcess
GO:0032991protein-containing complex23349634.IDAComponent
GO:0043014alpha-tubulin binding-IEAFunction
GO:0045345positive regulation of MHC class I biosynthetic process12952910.TASProcess
GO:0050790regulation of catalytic activity-IEAProcess
GO:0051085chaperone cofactor-dependent protein refolding-IEAProcess
GO:0051135positive regulation of NK T cell activation12952910.TASProcess
GO:0070062extracellular exosome20458337.HDAComponent
GO:0071682endocytic vesicle lumen-TASComponent
GO:1900034regulation of cellular response to heat-TASProcess
To top

Copyright © , Bioinformatics Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, China. All Rights Reserved.

Any comment and suggestion, please contact us