EuRBPDB

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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
25174799MicroRNA-645, up-regulated in human adencarcinoma of gastric esophageal junction, inhibits apoptosis by targeting tumor suppressor IFIT2.BMC Cancer2014 Aug 29Feng Xdoi: 10.1186/1471-2407-14-633.
21190939The interferon stimulated gene 54 promotes apoptosis.J Biol Chem2011 Mar 4Stawowczyk Mdoi: 10.1074/jbc.M110.207068
28367102Inhibition of Proteasome Activity Induces Aggregation of IFIT2 in the Centrosome and Enhances IFIT2-Induced Cell Apoptosis.Int J Biol Sci2017 Feb 25Chen Ldoi: 10.7150/ijbs.17236

Differential Expression

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
BLCAchr10893019665'UTRnovel0.29
BLCAchr1089302126Translation_Start_SiteNAM1?0.26
BLCAchr1089306614Missense_MutationNAH220Y0.12
BLCAchr1089307097Nonsense_MutationNAQ381*0.65
BLCAchr10893020565'UTRnovel0.54
BLCAchr1089306935Missense_Mutationrs763699307D327N0.1
BLCAchr1089306065Frame_Shift_DelnovelV38Yfs*230.66
BRCAchr1089306245Frame_Shift_InsnovelN99Kfs*270.3
BRCAchr1089306550SilentNAL198L0.25
BRCAchr1089307310Missense_MutationnovelD452H0.44
BRCAchr1089306513Nonsense_MutationnovelD186_N187ins*0.17
BRCAchr1089306542Missense_MutationNAD196N0.3
CESCchr1089307169Missense_MutationNAS405A0.59
CESCchr1089306686Missense_MutationNAP244S0.31
CESCchr10893021065'UTRnovel0.21
COADchr1089307220Nonsense_Mutationrs773031617R422*0.2
COADchr1089307206Missense_MutationnovelK417T0.29
COADchr1089306707Missense_Mutationrs537050168R251C0.28
COADchr1089306767Nonsense_Mutationrs770640915K271*0.45
COADchr1089306857Missense_MutationnovelL301V0.17
COADchr1089306153Frame_Shift_DelnovelN67Tfs*140.28
COADchr1089306767Frame_Shift_DelNAK272Rfs*30.12
COADchr1089306155Missense_MutationNAN67H0.23
COADchr1089306767Frame_Shift_DelNAK272Rfs*30.28
GBMchr1089307164Missense_MutationNAQ403L0.43
GBMchr1089306311Missense_MutationnovelK119Q0.15
GBMchr1089307042SilentnovelS362S0.43
GBMchr1089306781Missense_MutationnovelE275D0.07
GBMchr1089306832SilentnovelR292R0.11
HNSCchr1089307202Missense_MutationnovelQ416K0.24
HNSCchr10893020765'UTRnovel0.2
HNSCchr1089306694SilentnovelV246V0.27
KIRCchr1089306000Missense_MutationNAQ15P0.16
KIRCchr1089306911Missense_MutationNAA319S0.22
KIRPchr1089305996Missense_Mutationrs777976445R14W0.39
LAMLchr1089306128Missense_MutationnovelA58P0.08
LGGchr1089306505Nonsense_MutationnovelY183*0.3
LGGchr1089306593Missense_MutationNAV213I0.34
LGGchr1089306893Missense_Mutationrs774089331L313M0.38
LIHCchr1089306684Missense_MutationNAA243V0.09
LIHCchr1089306722Missense_MutationnovelF256I0.11
LUADchr10893073843'UTRnovel0.34
LUADchr10893020755'UTRnovel0.33
LUADchr1089306623Missense_Mutationrs370009481R223C0.14
LUADchr1089306155Missense_MutationNAN67H0.16
LUSCchr1089306708Missense_MutationNAR251H0.09
LUSCchr1089306248Missense_MutationNAG98R0.17
MESOchr1089306293Missense_Mutationrs769134303V113I0.44
OVchr1089306548Missense_MutationNAL198V0.43
OVchr1089306148Missense_MutationnovelK64N0.05
PRADchr1089307181Missense_MutationnovelE409K0.33
PRADchr1089306782Missense_MutationnovelY276N0.18
PRADchr1089306686Missense_MutationNAP244S0.39
PRADchr1089307013Missense_MutationnovelA353T0.09
READchr1089306772Missense_MutationnovelK272N0.1
READchr1089302126Translation_Start_SiteNAM1?0.41
READchr1089306466Missense_MutationNAK170N0.41
READchr1089307141Missense_MutationnovelF395L0.38
SKCMchr1089306328Nonsense_MutationnovelC124*0.07
SKCMchr1089306439Missense_MutationNAF161L0.1
SKCMchr1089306366Missense_MutationNAE137G0.32
SKCMchr1089306778Missense_MutationNAL274F0.1
SKCMchr10893021235'UTRnovel0.77
SKCMchr1089306546Missense_MutationNAP197L0.36
SKCMchr1089306350Missense_Mutationrs759821795R132G0.2
SKCMchr1089306685Silentrs190103711A243A0.26
SKCMchr1089306686Missense_MutationNAP244S0.27
STADchr1089306426Missense_Mutationrs773713688A157V0.2
STADchr1089307146Missense_MutationNAE397A0.18
STADchr1089306501Missense_MutationNAS182I0.12
STADchr1089306707Missense_Mutationrs537050168R251C0.35
STADchr1089306657Missense_MutationNAK234R0.15
STADchr1089306293Missense_Mutationrs769134303V113I0.23
STADchr1089306946SilentNAN330N0.06
STADchr1089306989Missense_MutationNAA345T0.34
STADchr1089307074Missense_MutationnovelL373P0.35
THCAchr10893073943'UTRnovel0.12
UCECchr1089306604SilentnovelA216A0.43
UCECchr1089307018Missense_MutationnovelE354D0.14
UCECchr1089306480Frame_Shift_InsnovelS176Ifs*220.12
UCECchr1089307224Missense_MutationnovelL423H0.26
UCECchr10893073973'UTRnovel0.3
UCECchr1089306383Missense_MutationnovelG143R0.37
UCECchr1089307220Nonsense_Mutationrs773031617R422*0.52
UCECchr1089307292Missense_Mutationrs148978582M446V0.19
UCECchr1089306466Missense_MutationNAK170N0.48
UCECchr1089307138Missense_MutationNAH394Q0.34
UCECchr1089306679Silentrs765899784E241E0.34
UCECchr1089306096Missense_Mutationrs373422979R47H0.11
UCECchr1089306426Missense_Mutationrs773713688A157V0.52
UCECchr1089306025Missense_MutationnovelN23K0.28
UCECchr1089307212Missense_MutationnovelA419V0.47
UCECchr1089307340Missense_MutationnovelL462I0.48
UCECchr1089306673SilentnovelA239A0.42
UCECchr1089307128In_Frame_InsnovelA391_I392insSSTN0.08
UCECchr1089306743Missense_MutationnovelP263S0.1
UCECchr1089306959Missense_Mutationrs368019671R335C0.23
UCECchr1089306335Missense_MutationnovelF127L0.32
UCECchr1089306536Missense_Mutationrs144300435A194T0.42
UCECchr1089306977Missense_MutationnovelA341P0.36
UCECchr1089306056Missense_MutationnovelF34V0.41
UCECchr1089306753Missense_Mutationrs370750247A266V0.24
UCECchr1089307220Nonsense_Mutationrs773031617R422*0.27
UCECchr1089306426Missense_Mutationrs773713688A157V0.34
UCECchr1089306896Missense_MutationnovelE314K0.33
UCECchr1089307114SilentnovelK386K0.3
UCECchr1089306699Frame_Shift_InsnovelV249Ffs*150.18
UCECchr1089305974Missense_MutationNAK6N0.45
UCECchr1089307173Missense_MutationNAR406M0.1
UCECchr1089306441In_Frame_InsnovelE162_K163insFT0.15
UCECchr1089306387Missense_MutationnovelW144L0.21
UCECchr1089306761Missense_MutationnovelL269M0.21
UCECchr1089306838Missense_MutationnovelK294N0.46
UCECchr1089306912Missense_MutationnovelA319V0.37
UCECchr1089306911Missense_Mutationrs775027680A319T0.36
UCSchr1089306053Missense_MutationnovelD33Y0.34

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
ACCDEL0.11110.19593
CHOLDEL0.16670.048655
DLBCDEL0.1250.00048456
ESCADEL0.26090.00081373
MESODEL0.25290.00015289
PAADDEL0.1250.169
READDEL0.25450.014135
THCADEL0.0220.011063
THYMDEL0.03250.10563
UCSDEL0.30360.1218

Survival Analysis
CancerP-value Q-value
THYM0.0096

Kaplan-Meier Survival Analysis

STAD0.026

Kaplan-Meier Survival Analysis

SARC0.0097

Kaplan-Meier Survival Analysis

MESO0.0012

Kaplan-Meier Survival Analysis

SKCM0.0001

Kaplan-Meier Survival Analysis

TGCT0.031

Kaplan-Meier Survival Analysis

PAAD0.00041

Kaplan-Meier Survival Analysis

LAML0.0081

Kaplan-Meier Survival Analysis

GBM0.034

Kaplan-Meier Survival Analysis

CHOL0.043

Kaplan-Meier Survival Analysis

THCA0.013

Kaplan-Meier Survival Analysis

Drugs

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Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBPome
  • Literatures
  • Expression
  • Transcripts
  • Gene Model
  • Phenotypes
  • GWAS
  • PPI
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000119922 (Gene tree)
Gene ID
3433
Gene Symbol
IFIT2
Alias
IFI-54|ISG-54K|cig42|GARG-39|IFI54|G10P2
Full Name
interferon induced protein with tetratricopeptide repeats 2
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Plus strand
Length
25,583 bases
Position
chr10:89,283,694-89,309,276
Accession
5409
RBP type
non-canonical RBP
Summary
(Interferon Induced Protein With Tetratricopeptide Repeats 2) is a Protein Coding gene. Among its related pathways are Immune response IFN alpha/beta signaling pathway and Type II interferon signaling (IFNG). An important paralog of this gene is IFIT3.
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
22658674Insights into RNA biology from an atlas of mammalian mRNA-binding proteinsRIC & Hela2012 May 31Castello ADOI: 10.1016/j.cell.2012.04.031
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & Hela2018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
22825553Crystal structure of ISG54 reveals a novel RNA binding structure and potential functional mechanisms.Cell Res2012 SepYang Zdoi: 10.1038/cr.2012.111
28637751Ifit2 Is a Restriction Factor in Rabies Virus Pathogenicity.J Virol2017 Aug 10Davis BMdoi: 10.1128/JVI.00889-17
11533154Activation of interferon response factor-3 in human cells infected with herpes simplex virus type 1 or human cytomegalovirus.J Virol2001 OctPreston CM-
15194680Histone deacetylase activity is required to recruit RNA polymerase II to the promoters of selected interferon-stimulated early response genes.J Biol Chem2004 Sep 24Sakamoto S-
29554348IFIT3 and IFIT2/3 promote IFIT1-mediated translation inhibition by enhancing binding to non-self RNA.Nucleic Acids Res2018 Jun 1Fleith RCdoi: 10.1093/nar/gky191.
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000638108IFIT2-2033703-ENSP00000490935472 (aa)-P09913
ENST00000611722IFIT2-2023038-ENSP00000484770483 (aa)-A0A087X279
ENST00000371826IFIT2-2013489-ENSP00000360891472 (aa)-P09913
Gene Model
Click here to download ENSG00000119922's gene model file
Phenotypes
ensgIDTraitpValuePubmed ID
ENSG00000119922Proteins3.7480000E-005-
GWAS
ensgIDSNPChromosomePositionSNP-risk TraitPubmedID95% CIOr or BEAT EFO ID
ENSG00000119922rs49344701089307681CBlood protein levels29875488[0.15-0.27] unit increase0.21EFO_0007937
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000119922's network

* RBP PPI network refers to all genes directly bind to RBP
Orthologs identified by RBPome
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000119922IFIT29746.237ENSG00000152778IFIT59646.237Homo_sapiens
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0003723RNA binding22658674.HDAFunction
GO:0005515protein binding19416887.21190939.21642987.IPIFunction
GO:0005737cytoplasm21190939.IDAComponent
GO:0005783endoplasmic reticulum21190939.IDAComponent
GO:0005829cytosol21873635.IBAComponent
GO:0005829cytosol-TASComponent
GO:0008637apoptotic mitochondrial changes21190939.TASProcess
GO:0009615response to virus19416887.IDAProcess
GO:0009615response to virus21642987.IMPProcess
GO:0032091negative regulation of protein binding19416887.IDAProcess
GO:0035457cellular response to interferon-alpha-IEAProcess
GO:0043065positive regulation of apoptotic process21190939.IDAProcess
GO:0051607defense response to virus21873635.IBAProcess
GO:0060337type I interferon signaling pathway-TASProcess
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