EuRBPDB

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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
27517624Downregulation of microRNA-199b predicts unfavorable prognosis and emerges as a novel therapeutic target which contributes to PP2A inhibition in metastatic colorectal cancer.Oncotarget2017 Jun 20Crist??bal Idoi: 10.18632/oncotarget.11174.
24621013Proteomics identified overexpression of SET oncogene product and possible therapeutic utility of protein phosphatase 2A in alveolar soft part sarcoma.J Proteome Res2014 May 2Kubota Ddoi: 10.1021/pr400929h
27383536MicroRNA-125b Suppresses Ovarian Cancer Progression via Suppression of the Epithelial-Mesenchymal Transition Pathway by Targeting the SET Protein.Cell Physiol Biochem2016Ying Xdoi: 10.1159/000445642
16286244The tumor suppressor PP2A is functionally inactivated in blast crisis CML through the inhibitory activity of the BCR/ABL-regulated SET protein.Cancer Cell2005 NovNeviani P-
25388166Deregulation of the PP2A inhibitor SET shows promising therapeutic implications and determines poor clinical outcome in patients with metastatic colorectal cancer.Clin Cancer Res2015 Jan 15Crist??bal Idoi: 10.1158/1078-0432.CCR-14-0724
25234598Stable SET knockdown in breast cell carcinoma inhibits cell migration and invasion.Biochem Biophys Res Commun2014 Oct 10Li Jdoi: 10.1016/j.bbrc.2014.09.013
26563471Inhibition of Pten deficient Castration Resistant Prostate Cancer by Targeting of the SET - PP2A Signaling axis.Sci Rep2015 Nov 13Hu Xdoi: 10.1038/srep15182.
26234767PP2A inhibition as a novel therapeutic target in castration-resistant prostate cancer.Tumour Biol2015 AugGonz??lez-Alonso Pdoi: 10.1007/s13277-015-3849-5
22739068SET protein accumulates in HNSCC and contributes to cell survival: antioxidant defense, Akt phosphorylation and AVOs acidification.Oral Oncol2012 NovLeopoldino AMdoi: 10.1016/j.oraloncology.2012.05.014
15930275PCOTH, a novel gene overexpressed in prostate cancers, promotes prostate cancer cell growth through phosphorylation of oncoprotein TAF-Ibeta/SET.Cancer Res2005 Jun 1Anazawa Y-
24025258Targeting inhibitor 2 of protein phosphatase 2A as a therapeutic strategy for prostate cancer treatment.Cancer Biol Ther2013 Oct 1Mukhopadhyay Adoi: 10.4161/cbt.25943
27035430Construction of SET overexpression vector and its effects on the proliferation and apoptosis of 293T cells.Mol Med Rep2016 MayWang Ydoi: 10.3892/mmr.2016.5049
28356029Oncogenic Role of SET/I2PP2A for Gynecologic Cancers.Curr Drug Targets2017Jiang SWdoi: 10.2174/1389450118666170328114506.

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
BLCAchr91286947073'UTRNA0.66
BLCAchr9128693728Missense_MutationnovelD208Y0.1
BLCAchr9128691855Splice_Regionnovel0.28
BLCAchr9128693790Missense_MutationnovelN228K0.16
BRCAchr9128691169Splice_SitenovelX38_splice0.32
BRCAchr9128692693SilentnovelE115E0.04
BRCAchr91286956973'UTRnovel0.2
BRCAchr91286963393'UTRnovel0.13
CESCchr91286948413'UTRnovel0.24
CESCchr9128691857Splice_SiteNAX57_splice0.3
CESCchr91286948943'UTRnovel0.24
CESCchr91286956293'UTRnovel0.74
CESCchr9128691957Missense_MutationnovelK90N0.28
CESCchr91286962283'UTRnovel0.28
CHOLchr91286954463'UTRnovel0.42
CHOLchr91286954483'UTRnovel0.39
COADchr9128691916Missense_MutationNAR77C0.41
COADchr9128693678Missense_MutationNAS191N0.41
COADchr9128689611Intronnovel0.6
COADchr9128693927Missense_MutationNAG245E0.25
COADchr9128691960Frame_Shift_DelNAP92Qfs*50.32
COADchr9128692958Missense_MutationNAE170K0.22
COADchr9128691947Missense_MutationnovelL87S0.08
COADchr9128692958Nonsense_MutationNAE170*0.25
COADchr9128693663Missense_Mutationrs150832256T186M0.48
ESCAchr91286954653'UTRnovel0.17
ESCAchr9128683929Missense_MutationnovelQ12E0.27
ESCAchr91286956183'UTRnovel0.22
ESCAchr91286958503'UTRnovel0.17
ESCAchr9128693663Missense_Mutationrs150832256T186M0.44
ESCAchr91286958073'UTRnovel0.41
ESCAchr9128692924SilentnovelL158L0.15
ESCAchr91286949803'UTRnovel0.15
HNSCchr9128693921Missense_MutationnovelG243A0.16
LGGchr9128694640Splice_SitenovelX284_splice0.08
LUADchr9128691905Missense_MutationnovelY73C0.5
LUSCchr9128694010Missense_MutationnovelD273Y0.56
MESOchr9128691880Missense_MutationnovelE65K0.43
OVchr9128694650Nonsense_MutationnovelG287*0.05
PAADchr9128692757Missense_MutationnovelI137L0.14
PRADchr9128692757Missense_MutationnovelI137V0.25
SARCchr9128691880Missense_MutationnovelE65K0.51
SKCMchr9128693682SilentNAR192R0.07
SKCMchr9128692935Frame_Shift_InsnovelD163*0.21
SKCMchr9128692922SilentNAL158L0.39
SKCMchr9128692884Missense_MutationNAP145L0.13
STADchr9128693645Missense_MutationNAT180M0.27
STADchr9128692755Missense_MutationNAR136T0.43
STADchr9128692976Missense_MutationnovelG176R0.25
STADchr9128693654Missense_Mutationrs142648600S183L0.3
STADchr9128692700Missense_MutationNAH118Y0.15
UCECchr9128691179Missense_MutationNAQ41P0.2
UCECchr91286838945'UTRnovel0.35
UCECchr9128691916Missense_MutationNAR77C0.35
UCECchr91286954743'UTRnovel0.21
UCECchr9128692760Missense_MutationnovelD138Y0.42
UCECchr9128683909Missense_MutationnovelR5H0.41
UCECchr91286963843'UTRrs5773995880.51
UCECchr91286948833'UTRnovel0.1
UCECchr9128691186Missense_MutationNAE43D0.45
UCECchr91286946963'UTRnovel0.19
UCECchr9128692702SilentnovelH118H0.06
UCECchr9128692727Nonsense_MutationnovelE127*0.2
UCECchr9128691929Missense_MutationnovelF81Y0.38
UCECchr91286955603'UTRnovel0.24
UCECchr91286953593'UTRnovel0.15
UCECchr91286957743'UTRnovel0.14
UCECchr91286963383'UTRnovel0.19
UCECchr9128691983Missense_MutationNAF99C0.24
UCECchr91286950253'UTRnovel0.2
UCECchr9128692904Missense_MutationnovelL152I0.28
UCECchr91286948833'UTRnovel0.42
UCECchr91286963863'UTRnovel0.45
UCECchr9128691882Missense_MutationNAE65D0.28
UCECchr91286948833'UTRnovel0.38
UCECchr91286951613'UTRnovel0.38
UCECchr91286963503'UTRnovel0.37
UCECchr91286947593'UTRnovel0.44
UCECchr9128692958Missense_MutationNAE170K0.33
UCECchr91286962213'UTRnovel0.31
UCECchr9128691952Missense_MutationnovelA89T0.43
UCECchr9128693706Missense_MutationnovelE200D0.32
UCECchr91286950913'UTRnovel0.24
UCECchr91286955443'UTRnovel0.21
UCECchr91286838345'UTRnovel0.37
UCECchr9128693650Missense_MutationnovelR182C0.38
UCECchr91286950453'UTRnovel0.2
UCECchr9128693980Missense_MutationNAE263K0.43
UCECchr9128683987Missense_MutationNAA31V0.19
UCECchr91286963863'UTRnovel0.58
UCECchr91286951633'UTRrs7626300440.26
UCECchr91286963863'UTRnovel0.21
UCECchr91286956303'UTRnovel0.19
UCECchr9128692661Splice_SitenovelX105_splice0.12
UCECchr9128692958Missense_MutationNAE170K0.16
UCECchr91286963863'UTRnovel0.82
UCECchr9128691218Missense_MutationnovelE54A0.28
UCECchr91286949413'UTRnovel0.33
UCECchr91286957773'UTRnovel0.15
UCECchr9128693657Missense_MutationNAS184I0.26
UCECchr9128692948SilentnovelS166S0.24
UCECchr91286955103'UTRnovel0.05

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
LAMLDEL0.00520.24147
LGGAMP0.06040.21332
LIHCDEL0.25140.12467
PRADAMP0.08130.059049
THCADEL0.04010.24038
THYMDEL0.01630.022012
UCSDEL0.57140.089783

Survival Analysis
CancerP-value Q-value
THYM0.0057

Kaplan-Meier Survival Analysis

KIRC0.0029

Kaplan-Meier Survival Analysis

SARC0.0019

Kaplan-Meier Survival Analysis

MESO0.00017

Kaplan-Meier Survival Analysis

ACC0.0001

Kaplan-Meier Survival Analysis

HNSC0.0042

Kaplan-Meier Survival Analysis

PAAD0.027

Kaplan-Meier Survival Analysis

BLCA0.049

Kaplan-Meier Survival Analysis

LIHC0.0001

Kaplan-Meier Survival Analysis

DLBC0.044

Kaplan-Meier Survival Analysis

LUAD0.0023

Kaplan-Meier Survival Analysis

Drugs

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Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBPome
  • Expression
  • Transcripts
  • Gene Model
  • Phenotypes
  • PPI
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000119335 (Gene tree)
Gene ID
6418
Gene Symbol
SET
Alias
PHAPII|2PP2A|IPP2A2|TAF-IBETA|IGAAD|TAF-I
Full Name
SET nuclear proto-oncogene
Gene Type
protein_coding
Species
Homo_sapiens
Status
putative
Strand
Plus strand
Length
12,977 bases
Position
chr9:128,683,424-128,696,400
Accession
10760
RBP type
non-canonical RBP
Summary
The protein encoded by this gene inhibits acetylation of nucleosomes, especially histone H4, by histone acetylases (HAT). This inhibition is most likely accomplished by masking histone lysines from being acetylated, and the consequence is to silence HAT-dependent transcription. The encoded protein is part of a complex localized to the endoplasmic reticulum but is found in the nucleus and inhibits apoptosis following attack by cytotoxic T lymphocytes. This protein can also enhance DNA replication of the adenovirus genome. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & HEK2932019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & HEK2932018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & MCF10A2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & U2OS2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000372686SET-2021029-ENSP00000361771265 (aa)-Q01105
ENST00000372688SET-203801-ENSP00000361773266 (aa)-A0A0C4DFV9
ENST00000372692SET-2042850XM_017015013ENSP00000361777290 (aa)XP_016870502Q01105
ENST00000466009SET-207597--- (aa)--
ENST00000322030SET-2012915XM_017015016ENSP00000318012277 (aa)XP_016870505Q01105
ENST00000409104SET-205962-ENSP00000387321268 (aa)-Q01105
ENST00000480536SET-210388--- (aa)--
ENST00000477806SET-208957--- (aa)--
ENST00000485056SET-211483--- (aa)--
ENST00000454747SET-206235-ENSP0000041080632 (aa)-B2REB7
ENST00000480217SET-209509--- (aa)--
Gene Model
Click here to download ENSG00000119335's gene model file
Phenotypes
ensgIDTraitpValuePubmed ID
ENSG00000119335Macular Degeneration5.41248E-6-
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000119335's network

* RBP PPI network refers to all genes directly bind to RBP
Orthologs identified by RBPome
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000119335SET10097.834ENSMUSG00000054766Set10097.834Mus_musculus
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0003677DNA binding-IEAFunction
GO:0004864protein phosphatase inhibitor activity8626647.TASFunction
GO:0005515protein binding11909973.16189514.17245428.17318177.19343227.20195357.21988832.23195690.24983498.25416956.IPIFunction
GO:0005634nucleus16791210.HDAComponent
GO:0005634nucleus11555662.IDAComponent
GO:0005634nucleus18374643.TASComponent
GO:0005654nucleoplasm-IDAComponent
GO:0005654nucleoplasm-TASComponent
GO:0005737cytoplasm11909973.12524539.IDAComponent
GO:0005783endoplasmic reticulum11555662.12524539.IDAComponent
GO:0005811lipid droplet-IDAComponent
GO:0005829cytosol-IEAComponent
GO:0006260DNA replication7753797.TASProcess
GO:0006334nucleosome assembly-IEAProcess
GO:0006337nucleosome disassembly11555662.TASProcess
GO:0016032viral process-IEAProcess
GO:0019888protein phosphatase regulator activity11555662.TASFunction
GO:0032515negative regulation of phosphoprotein phosphatase activity-IEAProcess
GO:0032991protein-containing complex11909973.IDAComponent
GO:0035067negative regulation of histone acetylation11555662.TASProcess
GO:0042393histone binding11555662.TASFunction
GO:0043488regulation of mRNA stability-TASProcess
GO:0043524negative regulation of neuron apoptotic process18374643.IGIProcess
GO:0045892negative regulation of transcription, DNA-templated19343227.IDAProcess
GO:0048471perinuclear region of cytoplasm11555662.12524539.IDAComponent
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