EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
23612256	Alu-related transcript of TJP2 gene as a marker for colorectal cancer.	Gene	2013 Jul 25	Kim YJ	doi: 10.1016/j.gene.2013.04.006
23605953	Regulation of membrane-type 1 matrix metalloproteinase expression by zonula occludens-2 in human lung cancer cells.	Clin Exp Metastasis	2013 Oct	Luczka E	doi: 10.1007/s10585-013-9583-8
22671599	ZO-2, a tight junction scaffold protein involved in the regulation of cell proliferation and apoptosis.	Ann N Y Acad Sci	2012 Jun	Gonzalez-Mariscal L	doi: 10.1111/j.1749-6632.2012.06537.x.

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
ACC	chr9	69216458	Silent	novel	L78L	0.45
ACC	chr9	69174267	5'UTR	novel		0.11
ACC	chr9	69246688	Splice_Site	novel	X856_splice	1
BLCA	chr9	69251070	Missense_Mutation	novel	F1009L	0.4
BLCA	chr9	69229230	Silent	NA	P500P	0.54
BLCA	chr9	69240088	Missense_Mutation	novel	S836Y	0.59
BLCA	chr9	69227827	Missense_Mutation	novel	D425H	0.47
BLCA	chr9	69227777	Missense_Mutation	novel	I408T	0.21
BLCA	chr9	69246577	Intron	novel		0.57
BLCA	chr9	69251299	Missense_Mutation	rs774499739	E1086K	0.2
BLCA	chr9	69229237	Nonsense_Mutation	NA	E503*	0.65
BLCA	chr9	69216372	Missense_Mutation	rs749225630	G50R	0.17
BLCA	chr9	69218268	Missense_Mutation	novel	R84T	0.67
BLCA	chr9	69221018	Missense_Mutation	novel	R158S	0.25
BLCA	chr9	69220954	Missense_Mutation	novel	D137G	0.07
BLCA	chr9	69221341	Missense_Mutation	novel	S266T	0.75
BRCA	chr9	69248283	Intron	rs768278655		0.18
BRCA	chr9	69212554	Missense_Mutation	NA	G23C	0.11
BRCA	chr9	69237054	Silent	novel	L699L	0.19
BRCA	chr9	69237955	Missense_Mutation	novel	D753Y	0.18
BRCA	chr9	69216396	Missense_Mutation	NA	E58Q	0.27
BRCA	chr9	69240105	Missense_Mutation	NA	Q842E	0.51
CESC	chr9	69248203	Silent	rs369972534	S953S	0.24
CESC	chr9	69252818	Missense_Mutation	NA	E1109K	0.39
CESC	chr9	69229189	Missense_Mutation	NA	Q487E	0.4
CESC	chr9	69246775	Missense_Mutation	novel	W884C	0.09
CESC	chr9	69174430	Missense_Mutation	NA	R20C	0.39
CESC	chr9	69174207	5'UTR	novel		0.29
CESC	chr9	69221316	Missense_Mutation	novel	D258N	0.33
CESC	chr9	69246755	Nonsense_Mutation	NA	Q878*	0.23
CESC	chr9	69251203	Missense_Mutation	rs57728054	T1054A	0.23
CESC	chr9	69216379	Missense_Mutation	NA	R52T	0.41
CESC	chr9	69240102	Missense_Mutation	NA	D841H	0.35
CESC	chr9	69249460	Missense_Mutation	novel	P989L	0.32
COAD	chr9	69248350	Intron	novel		0.34
COAD	chr9	69246614	Intron	novel		0.19
COAD	chr9	69226155	Missense_Mutation	novel	D397V	0.05
COAD	chr9	69240013	Frame_Shift_Del	rs776869985	*F813Sfs12**	0.23
COAD	chr9	69174351	5'UTR	novel		0.22
COAD	chr9	69237022	Missense_Mutation	rs779161706	R689C	0.28
COAD	chr9	69240120	Frame_Shift_Del	NA	*T849Rfs12**	0.32
COAD	chr9	69228072	Missense_Mutation	rs149386335	P471S	0.21
COAD	chr9	69221234	Silent	novel	G230G	0.06
COAD	chr9	69251281	Missense_Mutation	NA	G1080C	0.22
COAD	chr9	69246577	Intron	novel		0.3
COAD	chr9	69238787	Nonsense_Mutation	novel	Q785*	0.11
COAD	chr9	69221074	Frame_Shift_Del	novel	*R179Vfs132**	0.16
COAD	chr9	69221364	Missense_Mutation	novel	R274C	0.07
COAD	chr9	69227789	Missense_Mutation	rs748959984	R412Q	0.16
COAD	chr9	69225360	Missense_Mutation	novel	L337M	0.21
COAD	chr9	69254328	Missense_Mutation	novel	R1176H	0.36
COAD	chr9	69237001	Missense_Mutation	rs760622082	R682W	0.48
COAD	chr9	69236091	Missense_Mutation	novel	C615Y	0.4
COAD	chr9	69237893	Missense_Mutation	NA	P732H	0.25
COAD	chr9	69218258	Nonsense_Mutation	NA	E81*	0.13
COAD	chr9	69234498	Missense_Mutation	NA	E577D	0.3
COAD	chr9	69220920	Missense_Mutation	rs756272179	A126T	0.31
COAD	chr9	69249403	Missense_Mutation	rs150494393	R970Q	0.38
COAD	chr9	69246653	Intron	novel		0.33
COAD	chr9	69248150	Nonsense_Mutation	novel	E936*	0.05
COAD	chr9	69216459	Missense_Mutation	novel	L79I	0.16
COAD	chr9	69212597	Frame_Shift_Del	NA	*K38Rfs105**	0.44
COAD	chr9	69228107	Frame_Shift_Del	novel	*P484Qfs30**	0.18
COAD	chr9	69228108	Missense_Mutation	novel	P483T	0.18
COAD	chr9	69238742	Missense_Mutation	NA	S770T	0.39
COAD	chr9	69218360	Splice_Site	NA	X114_splice	0.6
COAD	chr9	69227812	Missense_Mutation	rs199761505	R420C	0.25
DLBC	chr9	69221194	Missense_Mutation	novel	R217H	0.16
ESCA	chr9	69221097	Missense_Mutation	novel	R185W	0.17
ESCA	chr9	69151741	5'UTR	novel		0.27
GBM	chr9	69236972	Missense_Mutation	novel	Q672L	0.13
GBM	chr9	69216459	Missense_Mutation	novel	L79F	0.22
GBM	chr9	69225402	Missense_Mutation	NA	L351I	0.14
GBM	chr9	69225342	Nonsense_Mutation	novel	E331*	0.34
GBM	chr9	69230132	Missense_Mutation	rs758151558	R524Q	0.54
HNSC	chr9	69236195	Missense_Mutation	novel	I650F	0.13
HNSC	chr9	69230157	Silent	novel	G532G	0.38
HNSC	chr9	69251239	Nonsense_Mutation	novel	E1066*	0.3
HNSC	chr9	69254448	3'UTR	novel		0.9
HNSC	chr9	69220953	Missense_Mutation	novel	D137Y	0.19
HNSC	chr9	69220953	Missense_Mutation	novel	D137N	0.25
HNSC	chr9	69230202	Missense_Mutation	novel	E547D	0.42
KIRC	chr9	69227863	Frame_Shift_Ins	novel	*R438Kfs23**	0.18
KIRP	chr9	69240101	Missense_Mutation	rs748208246	F840L	0.19
KIRP	chr9	69254368	Frame_Shift_Ins	novel	*L1190Ffs5**	0.3
LGG	chr9	69218346	Missense_Mutation	NA	K110R	0.37
LIHC	chr9	69254389	3'UTR	rs769076413		0.4
LIHC	chr9	69225356	Silent	NA	T335T	0.39
LIHC	chr9	69254532	3'UTR	novel		0.5
LUAD	chr9	69220921	Missense_Mutation	novel	A126E	0.12
LUAD	chr9	69237890	Missense_Mutation	novel	R731T	0.08
LUAD	chr9	69236142	Missense_Mutation	rs757972142	R632Q	0.29
LUAD	chr9	69236173	Silent	novel	L642L	0.28
LUAD	chr9	69237023	Missense_Mutation	NA	R689H	0.18
LUAD	chr9	69248111	Missense_Mutation	NA	E923K	0.51
LUAD	chr9	69254288	Nonsense_Mutation	NA	E1163*	0.24
LUSC	chr9	69251337	Missense_Mutation	novel	Q1098H	0.34
LUSC	chr9	69221199	Silent	rs750631073	R219R	0.13
LUSC	chr9	69240074	Silent	novel	T831T	0.22
LUSC	chr9	69251212	Missense_Mutation	novel	P1057S	0.36
LUSC	chr9	69227986	Missense_Mutation	novel	R442T	0.29
LUSC	chr9	69237001	Missense_Mutation	novel	R682G	0.57
LUSC	chr9	69248043	Missense_Mutation	rs773962012	R900H	0.12
LUSC	chr9	69221444	Missense_Mutation	novel	R300S	0.36
LUSC	chr9	69249388	Missense_Mutation	rs747689606	P965L	0.47
LUSC	chr9	69221332	Frame_Shift_Del	novel	*A264Pfs47**	0.83
LUSC	chr9	69248136	Missense_Mutation	NA	A931V	0.36
LUSC	chr9	69225346	Missense_Mutation	novel	M332T	0.56
OV	chr9	69226038	Missense_Mutation	NA	T358I	0.46
OV	chr9	69251132	Frame_Shift_Ins	novel	*S1031Dfs21**	0.05
OV	chr9	69237002	Missense_Mutation	novel	R682P	0.51
OV	chr9	69254303	Frame_Shift_Ins	novel	*Q1168Hfs48**	0.05
PAAD	chr9	69216409	Missense_Mutation	rs138241615	T62M	0.13
PAAD	chr9	69236171	Missense_Mutation	novel	L642M	0.18
PAAD	chr9	69246768	Missense_Mutation	NA	A882V	0.18
PAAD	chr9	69248134	Silent	NA	G930G	0.26
PAAD	chr9	69254327	Missense_Mutation	NA	R1176C	0.23
PRAD	chr9	69236166	Missense_Mutation	novel	G640D	0.06
PRAD	chr9	69246768	Missense_Mutation	NA	A882V	0.19
PRAD	chr9	69229198	Missense_Mutation	NA	A490P	0.04
PRAD	chr9	69226173	Missense_Mutation	NA	E403G	0.19
PRAD	chr9	69221007	Missense_Mutation	novel	Y155H	0.5
READ	chr9	69226050	Missense_Mutation	NA	S362Y	0.36
SARC	chr9	69254215	Frame_Shift_Ins	novel	E1141*	0.2
SARC	chr9	69252839	Missense_Mutation	novel	D1116N	0.11
SARC	chr9	69221265	Missense_Mutation	rs768090367	R241C	0.22
SARC	chr9	69229204	Missense_Mutation	rs267602261	P492S	0.41
SARC	chr9	69174367	5'UTR	novel		0.58
SARC	chr9	69251273	Missense_Mutation	novel	S1077L	0.36
SKCM	chr9	69251182	Missense_Mutation	rs148629740	R1047W	0.29
SKCM	chr9	69218290	Silent	novel	T91T	0.23
SKCM	chr9	69228028	Missense_Mutation	NA	P456L	0.32
SKCM	chr9	69225314	Silent	novel	L321L	0.59
SKCM	chr9	69220904	Silent	novel	R120R	0.75
SKCM	chr9	69218350	Silent	NA	V111V	0.35
SKCM	chr9	69249403	Missense_Mutation	rs150494393	R970Q	0.29
SKCM	chr9	69227800	Missense_Mutation	NA	P416S	0.35
SKCM	chr9	69230192	Missense_Mutation	NA	A544G	0.35
SKCM	chr9	69254350	Silent	novel	A1183A	0.26
SKCM	chr9	69254351	Nonsense_Mutation	rs756017678	R1184*	0.26
SKCM	chr9	69248018	Missense_Mutation	NA	G892R	0.26
SKCM	chr9	69246759	Missense_Mutation	NA	Q879L	0.17
SKCM	chr9	69234502	Missense_Mutation	rs539919973	P579S	0.1
SKCM	chr9	69248261	Intron	novel		0.31
SKCM	chr9	69234502	Missense_Mutation	rs539919973	P579S	0.4
SKCM	chr9	69236185	Silent	NA	L646L	0.33
SKCM	chr9	69237909	Silent	novel	G737G	0.32
SKCM	chr9	69237910	Missense_Mutation	novel	P738S	0.33
SKCM	chr9	69254358	Missense_Mutation	rs201144827	R1186Q	0.24
STAD	chr9	69225379	Missense_Mutation	rs763855572	N343S	0.33
STAD	chr9	69221176	Missense_Mutation	NA	R211H	0.21
STAD	chr9	69216439	Missense_Mutation	NA	G72D	0.1
STAD	chr9	69216437	Silent	rs780781603	P71P	0.37
STAD	chr9	69234445	Missense_Mutation	NA	T560A	0.28
STAD	chr9	69238769	Missense_Mutation	rs145368713	V779M	0.21
STAD	chr9	69221295	Nonsense_Mutation	NA	R251*	0.27
STAD	chr9	69212581	Missense_Mutation	rs776190114	Y32H	0.1
STAD	chr9	69248192	Frame_Shift_Del	novel	*T950Cfs7**	0.11
STAD	chr9	69237911	Missense_Mutation	NA	P738R	0.53
STAD	chr9	69240042	Missense_Mutation	NA	V821I	0.38
STAD	chr9	69254301	Missense_Mutation	rs370985421	R1167H	0.1
STAD	chr9	69216385	Missense_Mutation	NA	N54T	0.24
STAD	chr9	69251364	Missense_Mutation	NA	R1107S	0.24
STAD	chr9	69212551	Missense_Mutation	NA	P22T	0.18
STAD	chr9	69248135	Missense_Mutation	rs139276234	A931T	0.22
STAD	chr9	69240013	Frame_Shift_Del	rs776869985	*F813Sfs12**	0.17
UCEC	chr9	69226161	Missense_Mutation	novel	D399A	0.38
UCEC	chr9	69234543	Silent	rs17852440	A592A	0.18
UCEC	chr9	69252864	Missense_Mutation	rs376663560	T1124M	0.35
UCEC	chr9	69229219	Missense_Mutation	rs202036469	R497C	0.34
UCEC	chr9	69239947	Missense_Mutation	novel	A789V	0.42
UCEC	chr9	69174382	Nonsense_Mutation	NA	R4*	0.45
UCEC	chr9	69221436	Missense_Mutation	NA	E298K	0.55
UCEC	chr9	69251105	Missense_Mutation	novel	A1021V	0.15
UCEC	chr9	69227812	Missense_Mutation	rs199761505	R420C	0.24
UCEC	chr9	69237064	Silent	novel	R703R	0.41
UCEC	chr9	69252875	Missense_Mutation	novel	D1128Y	0.39
UCEC	chr9	69246721	Missense_Mutation	novel	S866R	0.47
UCEC	chr9	69248431	Intron	novel		0.23
UCEC	chr9	69174303	5'UTR	novel		0.42
UCEC	chr9	69251334	Missense_Mutation	novel	M1097I	0.43
UCEC	chr9	69228077	Missense_Mutation	novel	E472D	0.07
UCEC	chr9	69246696	Missense_Mutation	NA	I858T	0.29
UCEC	chr9	69248119	Silent	rs374453976	T925T	0.39
UCEC	chr9	69252817	Splice_Region	rs780660433	I1108I	0.21
UCEC	chr9	69251109	Silent	novel	V1022V	0.42
UCEC	chr9	69236175	Missense_Mutation	novel	G643D	0.11
UCEC	chr9	69225390	Nonsense_Mutation	NA	G347*	0.53
UCEC	chr9	69238724	Missense_Mutation	NA	D764N	0.33
UCEC	chr9	69240090	Nonsense_Mutation	rs746830415	R837*	0.36
UCEC	chr9	69254327	Missense_Mutation	NA	R1176C	0.15
UCEC	chr9	69225387	Missense_Mutation	rs765212887	E346K	0.22
UCEC	chr9	69246750	Missense_Mutation	novel	Q876R	0.29
UCEC	chr9	69248112	Missense_Mutation	novel	E923G	0.27
UCEC	chr9	69248464	Intron	novel		0.36
UCEC	chr9	69226038	Missense_Mutation	novel	T358N	0.34
UCEC	chr9	69248042	Missense_Mutation	rs374830612	R900C	0.44
UCEC	chr9	69246657	Intron	novel		0.32
UCEC	chr9	69236057	Missense_Mutation	novel	G604W	0.08
UCEC	chr9	69251335	Nonsense_Mutation	novel	Q1098*	0.51
UCEC	chr9	69221022	Missense_Mutation	rs755935175	R160W	0.33
UCEC	chr9	69220999	Missense_Mutation	novel	R152Q	0.67
UCEC	chr9	69238757	Missense_Mutation	rs147994200	R775W	0.61
UCEC	chr9	69251079	Silent	novel	S1012S	0.52
UCEC	chr9	69251316	Missense_Mutation	novel	K1091N	0.13
UCEC	chr9	69212556	Silent	NA	G23G	0.11
UCEC	chr9	69252897	Missense_Mutation	rs760371356	T1135M	0.34
UCEC	chr9	69174343	5'UTR	novel		0.4
UCEC	chr9	69237131	Missense_Mutation	rs369608760	R725Q	0.45
UCEC	chr9	69246684	Splice_Region	novel		0.38
UCEC	chr9	69251131	Missense_Mutation	novel	A1030T	0.13
UCEC	chr9	69254649	3'UTR	novel		0.31
UCEC	chr9	69248290	Intron	novel		0.44
UCEC	chr9	69239956	Missense_Mutation	NA	D792G	0.27
UCEC	chr9	69237032	Missense_Mutation	NA	R692M	0.35
UCEC	chr9	69248134	Silent	NA	G930G	0.08
UCEC	chr9	69248457	Intron	novel		0.17
UCEC	chr9	69151672	5'UTR	novel		0.33
UCEC	chr9	69212601	Missense_Mutation	novel	K38N	0.24
UCEC	chr9	69174228	5'UTR	novel		0.39
UCEC	chr9	69225386	Silent	rs144213955	H345H	0.43
UCEC	chr9	69248133	Missense_Mutation	rs552732939	G930D	0.08
UCEC	chr9	69236129	Missense_Mutation	novel	G628W	0.45
UCEC	chr9	69234544	Missense_Mutation	rs765819513	D593N	0.37
UCEC	chr9	69251070	Missense_Mutation	novel	F1009L	0.31
UCEC	chr9	69229220	Missense_Mutation	rs532438219	R497H	0.16
UCEC	chr9	69246573	Intron	novel		0.27
UCEC	chr9	69218359	Missense_Mutation	NA	I114M	0.5
UCEC	chr9	69254734	3'UTR	novel		0.22
UCEC	chr9	69216338	Splice_Site	NA	X39_splice	0.46
UCEC	chr9	69227869	Missense_Mutation	NA	P439S	0.3
UCEC	chr9	69252901	Splice_Site	NA	X1136_splice	0.39
UCEC	chr9	69254335	Silent	NA	Y1178Y	0.32
UCEC	chr9	69226038	Missense_Mutation	NA	T358I	0.37
UCEC	chr9	69236041	Silent	novel	I598I	0.34
UCEC	chr9	69237932	Frame_Shift_Del	novel	*K746Nfs31**	0.21
UCEC	chr9	69237907	Missense_Mutation	rs139314808	G737S	0.34
UCEC	chr9	69221176	Missense_Mutation	NA	R211H	0.32
UCEC	chr9	69225402	Missense_Mutation	NA	L351I	0.44
UCEC	chr9	69227979	Splice_Site	novel	X440_splice	0.39
UCEC	chr9	69252820	Missense_Mutation	novel	E1109D	0.43
UCEC	chr9	69225335	Silent	novel	F328F	0.3
UCEC	chr9	69234469	Missense_Mutation	NA	R568W	0.35
UCEC	chr9	69251079	Silent	novel	S1012S	0.2
UCEC	chr9	69254498	3'UTR	rs757235477		0.19
UCEC	chr9	69174316	5'UTR	novel		0.49
UCEC	chr9	69236217	Missense_Mutation	novel	G657V	0.45

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
CHOL	DEL	0.4722	0.067545
LAML	DEL	0.0262	0.24147
PCPG	DEL	0.0679	0.13351
THCA	DEL	0.0401	0.24038
THYM	DEL	0.0163	0.022012
UCEC	DEL	0.2134	0.027215
UCS	DEL	0.5893	0.089783

Survival Analysis

Cancer	P-value	Q-value
STAD	0.038	Kaplan-Meier Survival Analysis
HNSC	0.04	Kaplan-Meier Survival Analysis
SKCM	0.025	Kaplan-Meier Survival Analysis
KIRP	0.021	Kaplan-Meier Survival Analysis
PAAD	0.00094	Kaplan-Meier Survival Analysis
LAML	0.023	Kaplan-Meier Survival Analysis
LGG	0.0001	Kaplan-Meier Survival Analysis
CHOL	0.02	Kaplan-Meier Survival Analysis
THCA	0.0096	Kaplan-Meier Survival Analysis
OV	0.05	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000119139 (Gene tree)
Gene ID: 9414
Gene Symbol: TJP2
Alias: ZO-2|X104|ZO2|DFNA51
Full Name: tight junction protein 2
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 153,352 bases
Position: chr9:69,121,264-69,274,615
Accession: 11828
RBP type: non-canonical RBP
Summary: This gene encodes a zonula occluden that is a member of the membrane-associated guanylate kinase homolog family. The encoded protein functions as a component of the tight junction barrier in epithelial and endothelial cells and is necessary for proper assembly of tight junctions. Mutations in this gene have been identified in patients with hypercholanemia, and genomic duplication of a 270 kb region including this gene causes autosomal dominant deafness-51. Alternatively spliced transcripts encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000606364	TJP2-210	591	-	ENSP00000475926	134 (aa)	-	U3KQJ2
ENST00000636438	TJP2-212	4689	-	ENSP00000489860	1249 (aa)	-	A0A1B0GTW1
ENST00000648153	TJP2-217	573	-	-	- (aa)	-	-
ENST00000649927	TJP2-225	3374	-	-	- (aa)	-	-
ENST00000648204	TJP2-218	4725	-	ENSP00000497941	1190 (aa)	-	UPI0000141800
ENST00000636247	TJP2-211	3725	-	-	- (aa)	-	-
ENST00000648087	TJP2-216	5085	-	-	- (aa)	-	-
ENST00000348208	TJP2-201	4055	-	ENSP00000345893	1043 (aa)	-	Q9UDY2
ENST00000539225	TJP2-209	3838	-	ENSP00000438262	1221 (aa)	-	Q9UDY2
ENST00000650353	TJP2-230	3282	-	-	- (aa)	-	-
ENST00000649943	TJP2-227	5672	-	ENSP00000497539	1099 (aa)	-	-
ENST00000498204	TJP2-207	4685	-	-	- (aa)	-	-
ENST00000377259	TJP2-203	588	-	-	- (aa)	-	-
ENST00000535702	TJP2-208	3984	-	ENSP00000442090	1157 (aa)	-	Q9UDY2
ENST00000643713	TJP2-213	490	-	ENSP00000494704	5 (aa)	-	UPI000D1943BE
ENST00000648460	TJP2-220	611	-	-	- (aa)	-	-
ENST00000413932	TJP2-204	822	-	-	- (aa)	-	-
ENST00000648402	TJP2-219	1483	-	ENSP00000497596	134 (aa)	-	UPI00038BB0BE
ENST00000423935	TJP2-205	869	-	ENSP00000402941	161 (aa)	-	B1AN86
ENST00000650460	TJP2-232	2851	-	ENSP00000497787	621 (aa)	-	-
ENST00000649134	TJP2-223	3964	XM_017015328	ENSP00000498068	1047 (aa)	XP_016870817	UPI0007DC57BD
ENST00000650084	TJP2-228	4389	XM_005252314	ENSP00000497861	1191 (aa)	XP_005252371	-
ENST00000649114	TJP2-222	5344	-	ENSP00000497328	989 (aa)	-	-
ENST00000650522	TJP2-233	3774	-	-	- (aa)	-	-
ENST00000650378	TJP2-231	629	-	-	- (aa)	-	-
ENST00000649939	TJP2-226	597	-	ENSP00000498043	156 (aa)	-	-
ENST00000650333	TJP2-229	3612	-	ENSP00000496791	1128 (aa)	-	-
ENST00000649783	TJP2-224	4264	-	-	- (aa)	-	-
ENST00000648042	TJP2-215	2771	-	ENSP00000497059	652 (aa)	-	-
ENST00000647986	TJP2-214	2868	-	ENSP00000496877	851 (aa)	-	-
ENST00000648862	TJP2-221	464	-	-	- (aa)	-	-
ENST00000453658	TJP2-206	4129	XM_011519204	ENSP00000392178	1020 (aa)	XP_011517506	Q9UDY2
ENST00000377245	TJP2-202	4503	XM_011519206	ENSP00000366453	1190 (aa)	XP_011517508	Q9UDY2

Gene Model

Click here to download ENSG00000119139's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa04530	Tight junction	KEGG
hsa05110	Vibrio cholerae infection	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000119139	Cholesterol	3.51876109508958E-5	17903299
ENSG00000119139	Cholesterol, LDL	7.6855409045791E-5	17903299
ENSG00000119139	Platelet Function Tests	8.7621739E-007	-
ENSG00000119139	Platelet Function Tests	5.7002085E-006	-
ENSG00000119139	Platelet Function Tests	1.5512040E-012	-
ENSG00000119139	Child Development Disorders, Pervasive	1.1942000E-005	-
ENSG00000119139	Child Development Disorders, Pervasive	1.9014000E-006	-
ENSG00000119139	Glioma	1.3870000E-005	-
ENSG00000119139	Adipose Tissue	4E-6	22044751
ENSG00000119139	Seasonal Affective Disorder	9E-6	25562672
ENSG00000119139	Myopia	7E-21	27182965
ENSG00000119139	Education	2E-9	27020472
ENSG00000119139	Refractive Errors	2E-9	27020472
ENSG00000119139	Refraction, Ocular	7E-9	23396134
ENSG00000119139	Education	2E-9	27020472
ENSG00000119139	Refractive Errors	2E-9	27020472

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000119139	rs11145488	9	69156023	A	Spherical equivalent (joint analysis main effects and education interaction)	27020472			EFO_0004784\|EFO_0007814
ENSG00000119139	rs11145488	9	69156023	A	Spherical equivalent (joint analysis main effects and education interaction)	27020472			EFO_0004784\|EFO_0007814
ENSG00000119139	rs11145465	9	69151677	A	Refractive error	23396134	[0.083-0.165] unit decrease	0.124	HP_0000539
ENSG00000119139	rs11145465	9	69151677	A	Spherical equivalent	29808027	[0.067-0.135] unit decrease	0.1012	EFO_0007814
ENSG00000119139	rs11145465	9	69151677	A	Spherical equivalent	29808027	[0.066-0.136] unit decrease	0.1011	EFO_0007814
ENSG00000119139	rs11145461	9	69151203	T	Myopia (age of diagnosis)	29808027	[0.05-0.083] unit decrease	0.0668	EFO_0004847\|HP_0000545
ENSG00000119139	rs11145465	9	69151677	A	Spherical equivalent or myopia (age of diagnosis)	29808027	[NR] z score decrease	9.546	EFO_0004847\|HP_0000545\|EFO_0007814
ENSG00000119139	rs1538583	9	69176631	?	Glomerular filtration rate in type 2 diabetes	29703844	[1.70-4.19] unit increase	2.95	EFO_0005208\|EFO_0001360
ENSG00000119139	rs2282335	9	69251016	A	Renal sinus fat	22044751	[0.098-0.244] unit increase	0.171	EFO_0004864
ENSG00000119139	rs11145488	9	69156023	?	Myopia	27182965	[1.07-1.11]	1.0869565	HP_0000545
ENSG00000119139	rs62567129	9	69174188	?	Macular thickness	30535121	[0.28-0.61] unit increase	0.4451	EFO_0008375

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000119139's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000119139	TJP2	100	93.284	ENSMUSG00000024812	Tjp2	100	85.774	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0004385	guanylate kinase activity	8824195.	TAS	Function
GO:0005515	protein binding	15975580.18823282.22665060.23885123.	IPI	Function
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005829	cytosol	-	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0005886	plasma membrane	-	IDA	Component
GO:0005886	plasma membrane	-	TAS	Component
GO:0005912	adherens junction	-	IEA	Component
GO:0005923	bicellular tight junction	22006950.23885123.	IDA	Component
GO:0019904	protein domain specific binding	23885123.	IPI	Function
GO:0030054	cell junction	-	IDA	Component
GO:0030674	protein binding, bridging	23885123.	IDA	Function
GO:0035329	hippo signaling	-	TAS	Process
GO:0045296	cadherin binding	25468996.	HDA	Function
GO:0046037	GMP metabolic process	-	IEA	Process
GO:0046710	GDP metabolic process	-	IEA	Process
GO:0050892	intestinal absorption	23885123.	IMP	Process
GO:0090557	establishment of endothelial intestinal barrier	23885123.	IMP	Process
GO:0090559	regulation of membrane permeability	23885123.	IMP	Process

EuRBPDB

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Description

RBPome

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

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Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.