EuRBPDB

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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
29749494Downregulation of RPN2 induces apoptosis and inhibits migration and invasion in colon carcinoma.Oncol Rep2018 JulBi Cdoi: 10.3892/or.2018.6434
23959174Ribophorin II regulates breast tumor initiation and metastasis through the functional suppression of GSK3β.Sci Rep2013Takahashi RUdoi: 10.1038/srep02474.
25595901Prognostic and therapeutic impact of RPN2-mediated tumor malignancy in non-small-cell lung cancer.Oncotarget2015 Feb 20Fujita Y-
24884960RPN2-mediated glycosylation of tetraspanin CD63 regulates breast cancer cell malignancy.Mol Cancer2014 May 31Tominaga Ndoi: 10.1186/1476-4598-13-134.
18724378RPN2 gene confers docetaxel resistance in breast cancer.Nat Med2008 SepHonma Kdoi: 10.1038/nm.1858.

Differential Expression

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
ACCchr2037210094SilentnovelV305V0.19
BLCAchr2037230003Missense_MutationnovelE509K0.58
BLCAchr2037207278SilentnovelQ232Q0.16
BLCAchr2037236704SilentNAV626V0.11
BLCAchr2037232366Nonsense_MutationnovelS551*0.4
BLCAchr2037238417IntronNA0.42
BLCAchr2037230013Missense_Mutationrs151311325S512L0.23
BLCAchr2037234080Missense_MutationnovelH580Y0.8
BRCAchr2037230057Nonsense_MutationNAQ527*0.27
BRCAchr2037210161Missense_MutationnovelV328L0.13
CESCchr20372413993'UTRrs7477542000.5
CESCchr2037203884Splice_SitenovelX160_splice0.38
COADchr20372415423'UTRnovel0.35
COADchr2037204794Frame_Shift_DelnovelG196Afs*410.12
COADchr20372414003'UTRnovel0.42
COADchr2037238405Intronnovel0.28
COADchr2037225745Silentrs752016809F414F0.16
COADchr2037184332Missense_Mutationrs146095088V56M0.22
COADchr2037184291Missense_MutationNAD42G0.39
COADchr20372413993'UTRrs7477542000.71
ESCAchr20372413473'UTRnovel0.29
ESCAchr2037199099Missense_MutationnovelE118V0.45
ESCAchr2037236596Missense_MutationnovelM590I0.33
ESCAchr20372413993'UTRrs7477542000.47
GBMchr2037236665Silentrs201803454T613T0.47
GBMchr2037234021Missense_MutationnovelW560L0.04
GBMchr2037207407SilentNAP275P0.24
HNSCchr2037199169SilentnovelS141S0.04
HNSCchr2037210142Missense_MutationnovelQ321H0.28
HNSCchr2037228603Silentrs200454814A451A0.22
HNSCchr2037199104Missense_MutationnovelS120T0.22
HNSCchr2037199105Nonsense_MutationnovelS120*0.22
HNSCchr2037228694In_Frame_DelnovelY482_T489del0.17
HNSCchr2037199202SilentnovelL152L0.35
KIRCchr2037213836Missense_MutationNAD355Y0.26
KIRCchr2037203929Missense_MutationNAA175G0.06
KIRPchr2037236585Missense_MutationnovelL587M0.31
LAMLchr2037207297Missense_Mutationrs373475376A239T0.08
LGGchr2037184179Splice_SitenovelX5_splice0.32
LIHCchr2037232323Frame_Shift_DelnovelT539Pfs*100.41
LIHCchr2037238405Intronnovel0.32
LIHCchr2037184238SilentnovelT24T0.19
LIHCchr2037199147Missense_MutationnovelG134D0.04
LUADchr2037198490Nonsense_MutationNAE101*0.09
LUADchr2037232370SilentNAP552P0.14
LUADchr2037184235SilentnovelL23L0.09
LUADchr2037184289SilentnovelL41L0.3
LUADchr2037199123Missense_MutationnovelY126C0.68
LUADchr2037198404Missense_MutationNAC72Y0.08
LUADchr2037203904Missense_MutationNAT167A0.24
LUSCchr2037238400Intronnovel0.18
LUSCchr2037228686Missense_MutationnovelY479F0.31
LUSCchr2037225718SilentnovelT405T0.36
OVchr2037203955In_Frame_InsnovelI184delinsKL0.04
OVchr2037203956In_Frame_InsnovelI184_E185insLGSRNLP0.02
OVchr2037234043Silentrs757241492V567V0.32
OVchr2037236627Missense_MutationnovelQ601E0.03
OVchr2037234069Missense_Mutationrs755601800T576M0.18
OVchr2037230042Missense_MutationNAP522T0.3
OVchr2037207399Missense_MutationnovelV273F0.19
OVchr2037228595In_Frame_InsnovelF449delinsYHRI0.07
PRADchr2037204795Missense_MutationnovelG195E0.05
PRADchr2037204887Missense_MutationnovelP226S0.1
READchr2037228621Silentrs747878354N457N0.35
READchr2037199113Missense_MutationNAT123A0.31
SARCchr2037198431Missense_MutationnovelP81L0.29
SARCchr2037230039Missense_MutationnovelT521A0.21
SKCMchr2037184196SilentnovelF10F0.39
SKCMchr2037210154SilentNAF325F0.41
SKCMchr2037213817SilentnovelF348F0.31
SKCMchr2037232325SilentNAP537P0.18
SKCMchr2037207285Nonsense_MutationNAQ235*0.22
SKCMchr2037184258Missense_MutationNAK31R0.14
SKCMchr2037225733SilentNAS410S0.38
SKCMchr2037184200SilentNAL12L0.13
SKCMchr2037236650SilentNAI608I0.54
SKCMchr2037223890Missense_Mutationrs138101348I369F0.13
SKCMchr2037199197Missense_Mutationrs147803642R151C0.23
SKCMchr2037204778SilentNAA189A0.49
SKCMchr2037199158Missense_MutationNAP138S0.44
SKCMchr2037204892SilentNAS227S0.34
SKCMchr2037228691Missense_MutationnovelL481F0.3
STADchr2037234064SilentNAP574P0.06
STADchr2037223881Missense_MutationNAR366G0.19
STADchr2037207385Missense_MutationNAH268R0.12
STADchr2037228559Nonsense_MutationNAR437*0.15
STADchr2037229989Missense_Mutationrs139589912K504R0.13
STADchr2037228629Missense_MutationNAK460T0.09
STADchr20372413993'UTRnovel0.32
STADchr2037234028SilentnovelR562R0.11
STADchr2037184293Missense_Mutationrs201593369R43C0.09
STADchr2037230014Silentrs557396469S512S0.23
STADchr2037228711SilentNAD487D0.13
UCECchr2037203941Missense_MutationnovelS179I0.43
UCECchr20372413873'UTRnovel0.19
UCECchr20372413993'UTRrs7477542000.5
UCECchr2037207333Missense_MutationNAE251K0.31
UCECchr20372415053'UTRnovel0.07
UCECchr2037228554Missense_MutationNAF435S0.55
UCECchr2037210125Missense_Mutationrs778793118R316G0.37
UCECchr2037213865Missense_MutationnovelE364D0.38
UCECchr2037234031SilentnovelI563I0.2
UCECchr2037213824Missense_Mutationrs114711297E351K0.17
UCECchr2037210067SilentnovelL296L0.21
UCECchr2037225745Silentrs752016809F414F0.47
UCECchr2037229984SilentnovelV502V0.43
UCECchr2037238406Intronrs3753910190.38
UCECchr2037232314Missense_MutationnovelE534Q0.21
UCECchr2037232370Silentrs368527026P552P0.38
UCECchr2037200480Intronnovel0.34
UCECchr2037213773SilentnovelL334L0.51
UCECchr2037184237Missense_Mutationrs755181709T24M0.36
UCECchr2037184196SilentnovelF10F0.46
UCECchr20372415573'UTRnovel0.19
UCECchr20372413993'UTRrs7477542000.56
UCECchr20372413993'UTRrs7477542000.37
UCECchr2037210069Missense_MutationnovelS297Y0.38
UCECchr2037213824Missense_Mutationrs114711297E351K0.45
UCECchr2037204866Missense_Mutationrs778332605M219V0.27
UCECchr20372414443'UTRnovel0.34
UCECchr2037238409Intronnovel0.21
UCECchr2037184286Silentrs762745360S40S0.54
UCECchr2037213793Missense_MutationnovelK340N0.38
UCECchr2037199118SilentnovelQ124Q0.54
UCECchr2037207403Missense_MutationNAV274E0.39
UCECchr2037204793Silentrs368565035L194L0.2
UCECchr2037213793Missense_MutationnovelK340N0.08
UCECchr2037228607Missense_MutationnovelP453S0.33
UCECchr2037184359Missense_MutationnovelV65M0.34
UCECchr2037204879Missense_MutationnovelG223E0.36
UCECchr2037204838SilentnovelA209A0.44
UCECchr2037228714SilentNAA488A0.57
UCECchr20372413993'UTRrs7477542000.38
UCECchr2037232392Splice_SitenovelX559_splice0.18
UCECchr20372413993'UTRnovel0.36
UCECchr2037198400Missense_MutationNAA71S0.28
UCECchr2037230047SilentnovelK523K0.33
UCECchr2037198431Missense_MutationnovelP81L0.38
UCSchr2037234027Missense_MutationnovelR562L0.11

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
LAMLDEL0.02090.14746
READAMP0.87277.719e-21

Survival Analysis
CancerP-value Q-value
KIRC0.0067

Kaplan-Meier Survival Analysis

SARC0.00085

Kaplan-Meier Survival Analysis

MESO0.0073

Kaplan-Meier Survival Analysis

ACC0.048

Kaplan-Meier Survival Analysis

HNSC0.0005

Kaplan-Meier Survival Analysis

LUSC0.03

Kaplan-Meier Survival Analysis

BRCA0.046

Kaplan-Meier Survival Analysis

COAD0.02

Kaplan-Meier Survival Analysis

BLCA0.00078

Kaplan-Meier Survival Analysis

CESC0.039

Kaplan-Meier Survival Analysis

KICH0.016

Kaplan-Meier Survival Analysis

GBM0.045

Kaplan-Meier Survival Analysis

LIHC0.0001

Kaplan-Meier Survival Analysis

CHOL0.044

Kaplan-Meier Survival Analysis

UVM0.00084

Kaplan-Meier Survival Analysis

Drugs

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Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBPome
  • Expression
  • Transcripts
  • Gene Model
  • Pathways
  • Phenotypes
  • GWAS
  • PPI
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000118705 (Gene tree)
Gene ID
6185
Gene Symbol
RPN2
Alias
SWP1|RPNII|RIBIIR|RPN-II
Full Name
ribophorin II
Gene Type
protein_coding
Species
Homo_sapiens
Status
putative
Strand
Plus strand
Length
63,214 bases
Position
chr20:37,178,410-37,241,623
Accession
10382
RBP type
non-canonical RBP
Summary
This gene encodes a type I integral membrane protein found only in the rough endoplasmic reticulum. The encoded protein is part of an N-oligosaccharyl transferase complex that links high mannose oligosaccharides to asparagine residues found in the Asn-X-Ser/Thr consensus motif of nascent polypeptide chains. This protein is similar in sequence to the yeast oligosaccharyl transferase subunit SWP1. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & HEK2932018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & Hela2018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & MCF72018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000462163RPN2-207712-ENSP00000435563162 (aa)-F2Z3K5
ENST00000373632RPN2-2031073-ENSP00000362735344 (aa)-Q5JYR7
ENST00000373622RPN2-2022348XM_006723851ENSP00000362724615 (aa)XP_006723914P04844
ENST00000237530RPN2-2012515XM_006723852ENSP00000237530631 (aa)XP_006723915P04844
ENST00000456400RPN2-206453-ENSP00000399404147 (aa)-H0Y5M1
ENST00000470352RPN2-208511--- (aa)--
ENST00000456102RPN2-205791-ENSP00000399137166 (aa)-Q5JYR4
ENST00000437329RPN2-204520-ENSP00000409580138 (aa)-Q5JYR3
Gene Model
Click here to download ENSG00000118705's gene model file
Pathways
Pathway IDPathway NameSource
hsa00510N-Glycan biosynthesisKEGG
hsa01100Metabolic pathwaysKEGG
hsa04141Protein processing in endoplasmic reticulumKEGG
Phenotypes
ensgIDTraitpValuePubmed ID
ENSG00000118705Hippocampus6E-619668339
GWAS
ensgIDSNPChromosomePositionSNP-risk TraitPubmedID95% CIOr or BEAT EFO ID
ENSG00000118705rs60318822037181380?Hippocampal atrophy19668339EFO_0005039
ENSG00000118705rs744179472037181711?Initial pursuit acceleration in psychotic disorders29064472EFO_0000692|EFO_0008434|EFO_0000289|EFO_0005411
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000118705's network

* RBP PPI network refers to all genes directly bind to RBP
Orthologs identified by RBPome
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000118705RPN210036.471FBgn0034277OstDelta9833.488Drosophila_melanogaster
ENSG00000118705RPN210092.846ENSMUSG00000027642Rpn210092.846Mus_musculus
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0000421autophagosome membrane-IEAComponent
GO:0004579dolichyl-diphosphooligosaccharide-protein glycotransferase activity21873635.IBAFunction
GO:0004579dolichyl-diphosphooligosaccharide-protein glycotransferase activity15835887.NASFunction
GO:0005515protein binding24965446.29290612.IPIFunction
GO:0005789endoplasmic reticulum membrane-TASComponent
GO:0005791rough endoplasmic reticulum-IEAComponent
GO:0006464cellular protein modification process10660554.TASProcess
GO:0006487protein N-linked glycosylation21873635.IBAProcess
GO:0007568aging-IEAProcess
GO:0008250oligosaccharyltransferase complex15835887.TASComponent
GO:0016020membrane19946888.HDAComponent
GO:0016021integral component of membrane-IEAComponent
GO:0018279protein N-linked glycosylation via asparagine15835887.NASProcess
GO:0018279protein N-linked glycosylation via asparagine-TASProcess
GO:0042493response to drug-IEAProcess
GO:0043022ribosome binding-IEAFunction
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