EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
26478675	Aberrant expression of peroxiredoxin 1 and its clinical implications in liver cancer.	World J Gastroenterol	2015 Oct 14	Sun YL	doi: 10.3748/wjg.v21.i38.10840.
23971998	MicroRNA-510 promotes cell and tumor growth by targeting peroxiredoxin1 in breast cancer.	Breast Cancer Res	2013	Guo QJ	-
21980378	Proteomic analysis of ovarian cancer proximal fluids: validation of elevated peroxiredoxin 1 in patient peripheral circulation.	PLoS One	2011	Hoskins ER	doi: 10.1371/journal.pone.0025056
27503926	SIRT2 Deacetylates and Inhibits the Peroxidase Activity of Peroxiredoxin-1 to Sensitize Breast Cancer Cells to Oxidant Stress-Inducing Agents.	Cancer Res	2016 Sep 15	Fiskus W	doi: 10.1158/0008-5472.CAN-16-0126
29673884	Peroxiredoxin 1 promoted tumor metastasis and angiogenesis in colorectal cancer.	Pathol Res Pract	2018 May	Li HX	doi: 10.1016/j.prp.2018.03.026
30886505	MicroRNA-596 acts as a tumor suppressor in gastric cancer and is upregulated by promotor demethylation.	World J Gastroenterol	2019 Mar 14	Zhang Z	doi: 10.3748/wjg.v25.i10.1224.
26170166	The sulfiredoxin-peroxiredoxin (Srx-Prx) axis in cell signal transduction and cancer development.	Cancer Lett	2015 Oct 1	Mishra M	doi: 10.1016/j.canlet.2015.07.002
24297309	Diagnostic and prognostic significance of peroxiredoxin 1 expression in human hepatocellular carcinoma.	Med Oncol	2014 Jan	Sun QK	doi: 10.1007/s12032-013-0786-2
23914992	Proteomic analysis of non-small cell lung cancer tissue interstitial fluids.	World J Surg Oncol	2013 Aug 5	Li S	doi: 10.1186/1477-7819-11-173.
26636537	Dimeric peroxiredoxins are druggable targets in human Burkitt lymphoma.	Oncotarget	2016 Jan 12	Trzeciecka A	doi: 10.18632/oncotarget.6435.
21343392	Peroxiredoxin 1 controls prostate cancer growth through Toll-like receptor 4-dependent regulation of tumor vasculature.	Cancer Res	2011 Mar 1	Riddell JR	doi: 10.1158/0008-5472.CAN-10-3674
29656298	High Expression of Peroxiredoxin 1 Is Associated with Epithelial-Mesenchymal Transition Marker and Poor Prognosis in Gastric Cancer.	Med Sci Monit	2018 Apr 15	Yu W	-
14703116	Preferential elevation of Prx I and Trx expression in lung cancer cells following hypoxia and in human lung cancer tissues.	Cell Biol Toxicol	2003 Oct	Kim HJ	-
23615915	Prx1 modulates the chemosensitivity of lung cancer to docetaxel through suppression of FOXO1-induced apoptosis.	Int J Oncol	2013 Jul	Hwang KE	doi: 10.3892/ijo.2013.1918
22215146	Polymorphisms of peroxiredoxin 1, 2 and 6 are not associated with esophageal cancer.	J Cancer Res Clin Oncol	2012 Apr	Zhang B	doi: 10.1007/s00432-011-1119-5
18549262	Proteomic expression analysis of surgical human colorectal cancer tissues: up-regulation of PSB7, PRDX1, and SRP9 and hypoxic adaptation in cancer.	J Proteome Res	2008 Jul	Rho JH	doi: 10.1021/pr8000892
25162226	Induction of peroxiredoxin 1 by hypoxia regulates heme oxygenase-1 via NF-??B in oral cancer.	PLoS One	2014 Aug 27	Zhang M	doi: 10.1371/journal.pone.0105994
23113308	Expression of peroxiredoxin 1, 2, 3, and 6 genes in cancer cells during drug resistance formation.	Bull Exp Biol Med	2012 Oct	Kalinina EV	-
17606720	Elevated peroxiredoxin 1, but not NF-E2-related factor 2, is an independent prognostic factor for disease recurrence and reduced survival in stage I non-small cell lung cancer.	Clin Cancer Res	2007 Jul 1	Kim JH	-
23277276	Proteomics in HepG2 hepatocarcinoma cells with stably silenced expression of PRDX1.	J Proteomics	2013 Feb 21	Aguilar-Melero P	doi: 10.1016/j.jprot.2012.12.005
20631257	Selective association of peroxiredoxin 1 with genomic DNA and COX-2 upstream promoter elements in estrogen receptor negative breast cancer cells.	Mol Biol Cell	2010 Sep 1	Wang X	doi: 10.1091/mbc.E10-02-0160
26689287	PRX1 knockdown potentiates vitamin K3 toxicity in cancer cells: a potential new therapeutic perspective for an old drug.	J Exp Clin Cancer Res	2015 Dec 21	He T	doi: 10.1186/s13046-015-0270-2.
22537621	Peroxiredoxins and tropomyosins as plasma biomarkers for lung cancer and asbestos exposure.	Lung Cancer	2012 Aug	Rostila A	doi: 10.1016/j.lungcan.2012.03.024
16278420	Histone deacetylase inhibitor FK228 activates tumor suppressor Prdx1 with apoptosis induction in esophageal cancer cells.	Clin Cancer Res	2005 Nov 1	Hoshino I	-
23065574	ILK and PRDX1 are prognostic markers in squamous cell/adenosquamous carcinomas and adenocarcinoma of gallbladder.	Tumour Biol	2013 Feb	Li J	doi: 10.1007/s13277-012-0557-2
19902980	Proteomic identification of overexpressed PRDX 1 and its clinical implications in ovarian carcinoma.	J Proteome Res	2010 Jan	Chung KH	doi: 10.1021/pr900811x.
25011585	Peroxiredoxin-1 protects estrogen receptor α from oxidative stress-induced suppression and is a protein biomarker of favorable prognosis in breast cancer.	Breast Cancer Res	2014 Jul 10	O'Leary PC	doi: 10.1186/bcr3691.
27388124	Peroxiredoxin 1 interacts with and blocks the redox factor APE1 from activating interleukin-8 expression.	Sci Rep	2016 Jul 8	Nassour H	doi: 10.1038/srep29389.

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr1	45511385	Missense_Mutation	NA	D182N	0.36
BLCA	chr1	45515788	Missense_Mutation	NA	F42L	0.55
BLCA	chr1	45511377	Missense_Mutation	rs765714807	I184M	0.31
BLCA	chr1	45514939	Nonsense_Mutation	novel	S106*	0.39
BLCA	chr1	45515788	Missense_Mutation	NA	F42L	0.43
BRCA	chr1	45514899	Frame_Shift_Ins	novel	*L119Ffs4**	0.44
BRCA	chr1	45519016	Missense_Mutation	NA	H10Y	0.17
BRCA	chr1	45518982	Missense_Mutation	NA	M21T	0.23
CESC	chr1	45511377	Missense_Mutation	rs765714807	I184M	0.49
CESC	chr1	45514625	Silent	NA	I132I	0.4
CESC	chr1	45518989	Missense_Mutation	novel	A19T	0.41
CHOL	chr1	45519006	Frame_Shift_Del	novel	*H10Pfs61**	0.3
COAD	chr1	45515727	Missense_Mutation	NA	A63T	0.23
COAD	chr1	45511349	Missense_Mutation	novel	Y194H	0.28
COAD	chr1	45515794	Silent	novel	V40V	0.11
ESCA	chr1	45514635	Missense_Mutation	novel	G129D	0.44
ESCA	chr1	45511358	Missense_Mutation	novel	S191R	0.64
KIRC	chr1	45519001	Missense_Mutation	NA	F15L	0.18
LGG	chr1	45511415	Splice_Site	novel	X172_splice	0.1
LGG	chr1	45515808	Splice_Site	novel	X36_splice	0.47
LIHC	chr1	45511365	Silent	NA	V188V	0.41
LUAD	chr1	45515663	Missense_Mutation	NA	H84P	0.14
LUAD	chr1	45515737	Silent	rs760500844	F59F	0.27
LUAD	chr1	45515780	Missense_Mutation	novel	P45L	0.19
LUAD	chr1	45515804	Splice_Site	novel	X36_splice	0.05
LUAD	chr1	45511377	Missense_Mutation	rs765714807	I184M	0.2
LUAD	chr1	45515714	Missense_Mutation	novel	K67R	0.18
LUSC	chr1	45514974	Silent	NA	Q94Q	0.35
LUSC	chr1	45515729	Missense_Mutation	NA	R62T	0.28
PAAD	chr1	45511374	Missense_Mutation	novel	K185N	0.17
PRAD	chr1	45514980	Missense_Mutation	novel	K92N	0.34
READ	chr1	45515721	Nonsense_Mutation	rs771022045	E65*	0.41
SKCM	chr1	45511381	Frame_Shift_Ins	novel	*T183Nfs5**	0.15
SKCM	chr1	45514540	Nonsense_Mutation	NA	Q161*	0.56
SKCM	chr1	45514603	Missense_Mutation	rs767893863	R140W	0.32
SKCM	chr1	45519048	5'UTR	novel		0.14
SKCM	chr1	45514934	Missense_Mutation	NA	P108S	0.14
STAD	chr1	45511352	Nonsense_Mutation	NA	E193*	0.28
THCA	chr1	45518946	Missense_Mutation	NA	D33G	0.06
UCEC	chr1	45514926	Silent	NA	R110R	0.23
UCEC	chr1	45514962	Silent	NA	G98G	0.35
UCEC	chr1	45515721	Nonsense_Mutation	rs771022045	E65*	0.23
UCEC	chr1	45518962	Missense_Mutation	novel	D28Y	0.31
UCEC	chr1	45514932	Silent	rs765244504	P108P	0.39
UCEC	chr1	45515747	Missense_Mutation	novel	I56T	0.46
UCEC	chr1	45515721	Nonsense_Mutation	rs771022045	E65*	0.07
UCEC	chr1	45515721	Nonsense_Mutation	rs771022045	E65*	0.19
UCEC	chr1	45514878	Silent	novel	S126S	0.25
UCEC	chr1	45515702	Missense_Mutation	novel	C71Y	0.23

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
DLBC	DEL	0.0833	0.011841
TGCT	DEL	0.16	0.00046313

Survival Analysis

Cancer	P-value	Q-value
KIRP	0.032	Kaplan-Meier Survival Analysis
PAAD	0.025	Kaplan-Meier Survival Analysis
BLCA	0.00075	Kaplan-Meier Survival Analysis
LAML	0.028	Kaplan-Meier Survival Analysis
LIHC	0.0001	Kaplan-Meier Survival Analysis
DLBC	0.05	Kaplan-Meier Survival Analysis
LGG	0.00011	Kaplan-Meier Survival Analysis
OV	0.038	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000117450 (Gene tree)
Gene ID: 5052
Gene Symbol: PRDX1
Alias: NKEFA|PAGA
Full Name: peroxiredoxin 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 12,013 bases
Position: chr1:45,511,035-45,523,047
Accession: 9352
RBP type: non-canonical RBP
Summary: This gene encodes a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. The encoded protein may play an antioxidant protective role in cells, and may contribute to the antiviral activity of CD8(+) T-cells. This protein may have a proliferative effect and play a role in cancer development or progression. Four transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jan 2011]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	NascentRICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RIC & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
27453046	Comprehensive Identification of RNA-Binding Domains in Human Cells	RIC & Hela	2016 Aug 18	Castello A	DOI: 10.1016/j.molcel.2016.06.029
30352994	Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome capture	RIC & Jurkat	2018 Oct 23	Perez-Perri JI	DOI:10.1038/s41467-018-06557-8

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
21159870	Peroxiredoxin 1 is required for efficient transcription and replication of measles virus.	J Virol	2011 Mar	Watanabe A	doi: 10.1128/JVI.01796-10
31158443	Peroxiredoxin 1 post-transcriptionally regulates snoRNA expression.	Free Radic Biol Med	2019 May 31	Kim EK	doi: 10.1016/j.freeradbiomed.2019.05.030
22877757	RNA-binding properties and RNA chaperone activity of human peroxiredoxin 1.	Biochem Biophys Res Commun	2012 Sep 7	Kim JH	doi: 10.1016/j.bbrc.2012.07.142

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000262746	PRDX1-201	1234	-	ENSP00000262746	199 (aa)	-	Q06830
ENST00000483583	PRDX1-206	530	-	-	- (aa)	-	-
ENST00000447184	PRDX1-205	606	-	ENSP00000407034	171 (aa)	-	A0A0A0MSI0
ENST00000424390	PRDX1-204	795	-	ENSP00000389047	171 (aa)	-	A0A0A0MSI0
ENST00000319248	PRDX1-202	1021	-	ENSP00000361152	199 (aa)	-	Q06830
ENST00000372079	PRDX1-203	609	-	ENSP00000361150	97 (aa)	-	A0A0A0MRQ5

Gene Model

Click here to download ENSG00000117450's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa04146	Peroxisome	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000117450	Language Tests	7.4473000E-005	-
ENSG00000117450	Homocysteine	2E-9	23824729

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000117450	rs4660306	1	45513003	T	Homocysteine levels	23824729	[0.03-0.057] unit increase	0.0435	EFO_0004578

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000117450's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000117450	PRDX1	100	95.477	ENSMUSG00000028691	Prdx1	100	95.935	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0001501	skeletal system development	8089076.	TAS	Process
GO:0001895	retina homeostasis	23580065.	HEP	Process
GO:0003723	RNA binding	22658674.22681889.	HDA	Function
GO:0004601	peroxidase activity	11986303.	IDA	Function
GO:0004601	peroxidase activity	-	TAS	Function
GO:0005515	protein binding	15105503.17909037.18172504.19369943.21044950.21969592.23386615.	IPI	Function
GO:0005615	extracellular space	22664934.23580065.	HDA	Component
GO:0005634	nucleus	21630459.	HDA	Component
GO:0005634	nucleus	17603937.	IDA	Component
GO:0005737	cytoplasm	21873635.	IBA	Component
GO:0005737	cytoplasm	17603937.	IDA	Component
GO:0005829	cytosol	21873635.	IBA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0006979	response to oxidative stress	21873635.	IBA	Process
GO:0008283	cell proliferation	-	IEA	Process
GO:0008379	thioredoxin peroxidase activity	21873635.	IBA	Function
GO:0008379	thioredoxin peroxidase activity	18606987.	IDA	Function
GO:0019430	removal of superoxide radicals	21873635.	IBA	Process
GO:0030101	natural killer cell activation	8462106.	IDA	Process
GO:0032872	regulation of stress-activated MAPK cascade	-	IEA	Process
GO:0034101	erythrocyte homeostasis	-	IEA	Process
GO:0034599	cellular response to oxidative stress	-	TAS	Process
GO:0042267	natural killer cell mediated cytotoxicity	-	IEA	Process
GO:0042470	melanosome	-	IEA	Component
GO:0042744	hydrogen peroxide catabolic process	21873635.	IBA	Process
GO:0042744	hydrogen peroxide catabolic process	11986303.18606987.	IDA	Process
GO:0042802	identical protein binding	-	IEA	Function
GO:0045296	cadherin binding	25468996.	HDA	Function
GO:0045321	leukocyte activation	21873635.	IBA	Process
GO:0045454	cell redox homeostasis	21873635.	IBA	Process
GO:0055114	oxidation-reduction process	-	IEA	Process
GO:0070062	extracellular exosome	19199708.20458337.23533145.	HDA	Component
GO:1901222	regulation of NIK/NF-kappaB signaling	-	IEA	Process

EuRBPDB

Note: to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.