EuRBPDB

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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
26478675Aberrant expression of peroxiredoxin 1 and its clinical implications in liver cancer.World J Gastroenterol2015 Oct 14Sun YLdoi: 10.3748/wjg.v21.i38.10840.
23971998MicroRNA-510 promotes cell and tumor growth by targeting peroxiredoxin1 in breast cancer.Breast Cancer Res2013Guo QJ-
21980378Proteomic analysis of ovarian cancer proximal fluids: validation of elevated peroxiredoxin 1 in patient peripheral circulation.PLoS One2011Hoskins ERdoi: 10.1371/journal.pone.0025056
27503926SIRT2 Deacetylates and Inhibits the Peroxidase Activity of Peroxiredoxin-1 to Sensitize Breast Cancer Cells to Oxidant Stress-Inducing Agents.Cancer Res2016 Sep 15Fiskus Wdoi: 10.1158/0008-5472.CAN-16-0126
29673884Peroxiredoxin 1 promoted tumor metastasis and angiogenesis in colorectal cancer.Pathol Res Pract2018 MayLi HXdoi: 10.1016/j.prp.2018.03.026
30886505MicroRNA-596 acts as a tumor suppressor in gastric cancer and is upregulated by promotor demethylation.World J Gastroenterol2019 Mar 14Zhang Zdoi: 10.3748/wjg.v25.i10.1224.
26170166The sulfiredoxin-peroxiredoxin (Srx-Prx) axis in cell signal transduction and cancer development.Cancer Lett2015 Oct 1Mishra Mdoi: 10.1016/j.canlet.2015.07.002
24297309Diagnostic and prognostic significance of peroxiredoxin 1 expression in human hepatocellular carcinoma.Med Oncol2014 JanSun QKdoi: 10.1007/s12032-013-0786-2
23914992Proteomic analysis of non-small cell lung cancer tissue interstitial fluids.World J Surg Oncol2013 Aug 5Li Sdoi: 10.1186/1477-7819-11-173.
26636537Dimeric peroxiredoxins are druggable targets in human Burkitt lymphoma.Oncotarget2016 Jan 12Trzeciecka Adoi: 10.18632/oncotarget.6435.
21343392Peroxiredoxin 1 controls prostate cancer growth through Toll-like receptor 4-dependent regulation of tumor vasculature.Cancer Res2011 Mar 1Riddell JRdoi: 10.1158/0008-5472.CAN-10-3674
29656298High Expression of Peroxiredoxin 1 Is Associated with Epithelial-Mesenchymal Transition Marker and Poor Prognosis in Gastric Cancer.Med Sci Monit2018 Apr 15Yu W-
14703116Preferential elevation of Prx I and Trx expression in lung cancer cells following hypoxia and in human lung cancer tissues.Cell Biol Toxicol2003 OctKim HJ-
23615915Prx1 modulates the chemosensitivity of lung cancer to docetaxel through suppression of FOXO1-induced apoptosis.Int J Oncol2013 JulHwang KEdoi: 10.3892/ijo.2013.1918
22215146Polymorphisms of peroxiredoxin 1, 2 and 6 are not associated with esophageal cancer.J Cancer Res Clin Oncol2012 AprZhang Bdoi: 10.1007/s00432-011-1119-5
18549262Proteomic expression analysis of surgical human colorectal cancer tissues: up-regulation of PSB7, PRDX1, and SRP9 and hypoxic adaptation in cancer.J Proteome Res2008 JulRho JHdoi: 10.1021/pr8000892
25162226Induction of peroxiredoxin 1 by hypoxia regulates heme oxygenase-1 via NF-??B in oral cancer.PLoS One2014 Aug 27Zhang Mdoi: 10.1371/journal.pone.0105994
23113308Expression of peroxiredoxin 1, 2, 3, and 6 genes in cancer cells during drug resistance formation.Bull Exp Biol Med2012 OctKalinina EV-
17606720Elevated peroxiredoxin 1, but not NF-E2-related factor 2, is an independent prognostic factor for disease recurrence and reduced survival in stage I non-small cell lung cancer.Clin Cancer Res2007 Jul 1Kim JH-
23277276Proteomics in HepG2 hepatocarcinoma cells with stably silenced expression of PRDX1.J Proteomics2013 Feb 21Aguilar-Melero Pdoi: 10.1016/j.jprot.2012.12.005
20631257Selective association of peroxiredoxin 1 with genomic DNA and COX-2 upstream promoter elements in estrogen receptor negative breast cancer cells.Mol Biol Cell2010 Sep 1Wang Xdoi: 10.1091/mbc.E10-02-0160
26689287PRX1 knockdown potentiates vitamin K3 toxicity in cancer cells: a potential new therapeutic perspective for an old drug.J Exp Clin Cancer Res2015 Dec 21He Tdoi: 10.1186/s13046-015-0270-2.
22537621Peroxiredoxins and tropomyosins as plasma biomarkers for lung cancer and asbestos exposure.Lung Cancer2012 AugRostila Adoi: 10.1016/j.lungcan.2012.03.024
16278420Histone deacetylase inhibitor FK228 activates tumor suppressor Prdx1 with apoptosis induction in esophageal cancer cells.Clin Cancer Res2005 Nov 1Hoshino I-
23065574ILK and PRDX1 are prognostic markers in squamous cell/adenosquamous carcinomas and adenocarcinoma of gallbladder.Tumour Biol2013 FebLi Jdoi: 10.1007/s13277-012-0557-2
19902980Proteomic identification of overexpressed PRDX 1 and its clinical implications in ovarian carcinoma.J Proteome Res2010 JanChung KHdoi: 10.1021/pr900811x.
25011585Peroxiredoxin-1 protects estrogen receptor α from oxidative stress-induced suppression and is a protein biomarker of favorable prognosis in breast cancer.Breast Cancer Res2014 Jul 10O'Leary PCdoi: 10.1186/bcr3691.
27388124Peroxiredoxin 1 interacts with and blocks the redox factor APE1 from activating interleukin-8 expression.Sci Rep2016 Jul 8Nassour Hdoi: 10.1038/srep29389.

Differential Expression

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
BLCAchr145511385Missense_MutationNAD182N0.36
BLCAchr145515788Missense_MutationNAF42L0.55
BLCAchr145511377Missense_Mutationrs765714807I184M0.31
BLCAchr145514939Nonsense_MutationnovelS106*0.39
BLCAchr145515788Missense_MutationNAF42L0.43
BRCAchr145514899Frame_Shift_InsnovelL119Ffs*40.44
BRCAchr145519016Missense_MutationNAH10Y0.17
BRCAchr145518982Missense_MutationNAM21T0.23
CESCchr145511377Missense_Mutationrs765714807I184M0.49
CESCchr145514625SilentNAI132I0.4
CESCchr145518989Missense_MutationnovelA19T0.41
CHOLchr145519006Frame_Shift_DelnovelH10Pfs*610.3
COADchr145515727Missense_MutationNAA63T0.23
COADchr145511349Missense_MutationnovelY194H0.28
COADchr145515794SilentnovelV40V0.11
ESCAchr145514635Missense_MutationnovelG129D0.44
ESCAchr145511358Missense_MutationnovelS191R0.64
KIRCchr145519001Missense_MutationNAF15L0.18
LGGchr145511415Splice_SitenovelX172_splice0.1
LGGchr145515808Splice_SitenovelX36_splice0.47
LIHCchr145511365SilentNAV188V0.41
LUADchr145515663Missense_MutationNAH84P0.14
LUADchr145515737Silentrs760500844F59F0.27
LUADchr145515780Missense_MutationnovelP45L0.19
LUADchr145515804Splice_SitenovelX36_splice0.05
LUADchr145511377Missense_Mutationrs765714807I184M0.2
LUADchr145515714Missense_MutationnovelK67R0.18
LUSCchr145514974SilentNAQ94Q0.35
LUSCchr145515729Missense_MutationNAR62T0.28
PAADchr145511374Missense_MutationnovelK185N0.17
PRADchr145514980Missense_MutationnovelK92N0.34
READchr145515721Nonsense_Mutationrs771022045E65*0.41
SKCMchr145511381Frame_Shift_InsnovelT183Nfs*50.15
SKCMchr145514540Nonsense_MutationNAQ161*0.56
SKCMchr145514603Missense_Mutationrs767893863R140W0.32
SKCMchr1455190485'UTRnovel0.14
SKCMchr145514934Missense_MutationNAP108S0.14
STADchr145511352Nonsense_MutationNAE193*0.28
THCAchr145518946Missense_MutationNAD33G0.06
UCECchr145514926SilentNAR110R0.23
UCECchr145514962SilentNAG98G0.35
UCECchr145515721Nonsense_Mutationrs771022045E65*0.23
UCECchr145518962Missense_MutationnovelD28Y0.31
UCECchr145514932Silentrs765244504P108P0.39
UCECchr145515747Missense_MutationnovelI56T0.46
UCECchr145515721Nonsense_Mutationrs771022045E65*0.07
UCECchr145515721Nonsense_Mutationrs771022045E65*0.19
UCECchr145514878SilentnovelS126S0.25
UCECchr145515702Missense_MutationnovelC71Y0.23

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
DLBCDEL0.08330.011841
TGCTDEL0.160.00046313

Survival Analysis
CancerP-value Q-value
KIRP0.032

Kaplan-Meier Survival Analysis

PAAD0.025

Kaplan-Meier Survival Analysis

BLCA0.00075

Kaplan-Meier Survival Analysis

LAML0.028

Kaplan-Meier Survival Analysis

LIHC0.0001

Kaplan-Meier Survival Analysis

DLBC0.05

Kaplan-Meier Survival Analysis

LGG0.00011

Kaplan-Meier Survival Analysis

OV0.038

Kaplan-Meier Survival Analysis

Drugs

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Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBPome
  • Literatures
  • Expression
  • Transcripts
  • Gene Model
  • Pathways
  • Phenotypes
  • GWAS
  • PPI
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000117450 (Gene tree)
Gene ID
5052
Gene Symbol
PRDX1
Alias
NKEFA|PAGA
Full Name
peroxiredoxin 1
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Minus strand
Length
12,013 bases
Position
chr1:45,511,035-45,523,047
Accession
9352
RBP type
non-canonical RBP
Summary
This gene encodes a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. The encoded protein may play an antioxidant protective role in cells, and may contribute to the antiviral activity of CD8(+) T-cells. This protein may have a proliferative effect and play a role in cancer development or progression. Four transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jan 2011]
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
22681889The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts4SURIC & HEK2932012 MayBaltz AGDOI: 10.1016/j.molcel.2012.05.021
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & HEK2932018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
29431736Capturing the interactome of newly transcribed RNANascentRICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
29431736Capturing the interactome of newly transcribed RNAPolyT-RICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
29431736Capturing the interactome of newly transcribed RNARIC & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
29431736Capturing the interactome of newly transcribed RNARICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
22658674Insights into RNA biology from an atlas of mammalian mRNA-binding proteinsRIC & Hela2012 May 31Castello ADOI: 10.1016/j.cell.2012.04.031
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & Hela2018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & MCF72018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
27453046Comprehensive Identification of RNA-Binding Domains in Human CellsRIC & Hela2016 Aug 18Castello ADOI: 10.1016/j.molcel.2016.06.029
30352994Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome captureRIC & Jurkat2018 Oct 23Perez-Perri JIDOI:10.1038/s41467-018-06557-8

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
21159870Peroxiredoxin 1 is required for efficient transcription and replication of measles virus.J Virol2011 MarWatanabe Adoi: 10.1128/JVI.01796-10
31158443Peroxiredoxin 1 post-transcriptionally regulates snoRNA expression.Free Radic Biol Med2019 May 31Kim EKdoi: 10.1016/j.freeradbiomed.2019.05.030
22877757RNA-binding properties and RNA chaperone activity of human peroxiredoxin 1.Biochem Biophys Res Commun2012 Sep 7Kim JHdoi: 10.1016/j.bbrc.2012.07.142
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000262746PRDX1-2011234-ENSP00000262746199 (aa)-Q06830
ENST00000483583PRDX1-206530--- (aa)--
ENST00000447184PRDX1-205606-ENSP00000407034171 (aa)-A0A0A0MSI0
ENST00000424390PRDX1-204795-ENSP00000389047171 (aa)-A0A0A0MSI0
ENST00000319248PRDX1-2021021-ENSP00000361152199 (aa)-Q06830
ENST00000372079PRDX1-203609-ENSP0000036115097 (aa)-A0A0A0MRQ5
Gene Model
Click here to download ENSG00000117450's gene model file
Pathways
Pathway IDPathway NameSource
hsa04146PeroxisomeKEGG
Phenotypes
ensgIDTraitpValuePubmed ID
ENSG00000117450Language Tests7.4473000E-005-
ENSG00000117450Homocysteine2E-923824729
GWAS
ensgIDSNPChromosomePositionSNP-risk TraitPubmedID95% CIOr or BEAT EFO ID
ENSG00000117450rs4660306145513003THomocysteine levels23824729[0.03-0.057] unit increase0.0435EFO_0004578
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000117450's network

* RBP PPI network refers to all genes directly bind to RBP
Orthologs identified by RBPome
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000117450PRDX110095.477ENSMUSG00000028691Prdx110095.935Mus_musculus
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0001501skeletal system development8089076.TASProcess
GO:0001895retina homeostasis23580065.HEPProcess
GO:0003723RNA binding22658674.22681889.HDAFunction
GO:0004601peroxidase activity11986303.IDAFunction
GO:0004601peroxidase activity-TASFunction
GO:0005515protein binding15105503.17909037.18172504.19369943.21044950.21969592.23386615.IPIFunction
GO:0005615extracellular space22664934.23580065.HDAComponent
GO:0005634nucleus21630459.HDAComponent
GO:0005634nucleus17603937.IDAComponent
GO:0005737cytoplasm21873635.IBAComponent
GO:0005737cytoplasm17603937.IDAComponent
GO:0005829cytosol21873635.IBAComponent
GO:0005829cytosol-TASComponent
GO:0006979response to oxidative stress21873635.IBAProcess
GO:0008283cell proliferation-IEAProcess
GO:0008379thioredoxin peroxidase activity21873635.IBAFunction
GO:0008379thioredoxin peroxidase activity18606987.IDAFunction
GO:0019430removal of superoxide radicals21873635.IBAProcess
GO:0030101natural killer cell activation8462106.IDAProcess
GO:0032872regulation of stress-activated MAPK cascade-IEAProcess
GO:0034101erythrocyte homeostasis-IEAProcess
GO:0034599cellular response to oxidative stress-TASProcess
GO:0042267natural killer cell mediated cytotoxicity-IEAProcess
GO:0042470melanosome-IEAComponent
GO:0042744hydrogen peroxide catabolic process21873635.IBAProcess
GO:0042744hydrogen peroxide catabolic process11986303.18606987.IDAProcess
GO:0042802identical protein binding-IEAFunction
GO:0045296cadherin binding25468996.HDAFunction
GO:0045321leukocyte activation21873635.IBAProcess
GO:0045454cell redox homeostasis21873635.IBAProcess
GO:0055114oxidation-reduction process-IEAProcess
GO:0070062extracellular exosome19199708.20458337.23533145.HDAComponent
GO:1901222regulation of NIK/NF-kappaB signaling-IEAProcess
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