EuRBPDB

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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
29474458Positive cytoplasmic UCHL5 tumor expression in gastric cancer is linked to improved prognosis.PLoS One2018 Feb 23Arpalahti Ldoi: 10.1371/journal.pone.0193125
28681694UCHL5 expression associates with improved survival in lymph-node-positive rectal cancer.Tumour Biol2017 JulArpalahti Ldoi: 10.1177/1010428317716078.
25123264High expression of UCH37 is significantly associated with poor prognosis in human epithelial ovarian cancer.Tumour Biol2014 NovWang Ldoi: 10.1007/s13277-014-2446-3

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
BLCAchr11930599615'Flanknovel0.15
BLCAchr1193022958Missense_MutationnovelE272K0.48
BLCAchr1193051797Nonsense_MutationNAE33*0.19
BLCAchr1193059231SilentNAL10L0.23
BLCAchr11930595135'Flanknovel0.47
BLCAchr1193051802Missense_MutationnovelQ31P0.17
BRCAchr1193023853Silentrs769820397Q241Q0.05
BRCAchr1193029610SilentnovelL98L0.19
BRCAchr1193029403Missense_MutationNAH140R0.14
BRCAchr1193023018Missense_MutationNAQ252E0.22
CESCchr11930598985'Flanknovel0.14
CESCchr1193029577SilentnovelE109E0.29
CESCchr1193020425Intronnovel0.24
CESCchr11930599925'Flanknovel0.08
CESCchr11930599265'Flanknovel0.18
CESCchr11930162533'UTRnovel0.05
COADchr11930163323'UTRnovel0.05
COADchr1193018643Intronnovel0.28
COADchr1193049775Nonsense_MutationNAR73*0.56
COADchr11930595085'Flanknovel0.32
COADchr1193020418Intronnovel0.21
COADchr11930596755'Flanknovel0.07
COADchr11930593215'UTRrs7680180380.33
COADchr1193029393Silentrs375167412F143F0.28
COADchr1193049774Missense_MutationNAR73Q0.28
COADchr1193029411Frame_Shift_InsnovelQ138Lfs*160.08
ESCAchr11930163243'UTRnovel0.24
ESCAchr1193029650Missense_MutationnovelN85S0.3
GBMchr1193016372Missense_MutationnovelK323N0.35
HNSCchr11930599785'Flanknovel0.21
HNSCchr11930598795'Flanknovel0.44
HNSCchr11930593785'UTRnovel0.13
HNSCchr1193029638Missense_MutationnovelA89G0.16
HNSCchr11930162483'UTRrs1841326250.14
HNSCchr1193059195Missense_MutationnovelI22M0.65
HNSCchr1193016367Missense_MutationnovelA325G0.11
LIHCchr1193023947Splice_SiteNAX210_splice0.35
LUADchr1193018768Intronnovel0.25
LUADchr1193029535SilentNAA123A0.53
LUADchr11930594775'UTRnovel0.39
LUADchr11930599615'Flanknovel0.09
LUADchr1193029387Splice_SitenovelX145_splice0.1
LUADchr1193029193Missense_MutationnovelG184E0.77
LUADchr1193029579Frame_Shift_DelnovelE109Rfs*170.21
LUADchr11930597795'Flanknovel0.4
LUADchr1193023021Missense_MutationNAD251N0.05
LUADchr1193029239Missense_Mutationrs139595729V169L0.28
LUADchr11930594075'UTRnovel0.17
LUADchr1193016368Missense_MutationNAA325S0.23
LUSCchr11930594865'UTRnovel0.24
LUSCchr11930593885'UTRnovel0.23
LUSCchr1193059253Missense_MutationNAG3V0.23
LUSCchr1193023884Missense_MutationnovelY231F0.1
LUSCchr11930594725'UTRnovel0.16
LUSCchr1193022928Nonsense_MutationnovelK282*0.15
LUSCchr1193049852Splice_SiteNAX47_splice0.32
LUSCchr11930594195'UTRnovel0.33
LUSCchr1193029386Splice_SiteNAX145_splice0.2
LUSCchr1193023867In_Frame_DelnovelA236del0.21
LUSCchr11930162883'UTRnovel0.79
MESOchr1193049852Splice_SiteNAX47_splice0.44
OVchr11930594535'UTRnovel0.32
OVchr11930592705'UTRnovel0.57
PAADchr11930161483'UTRnovel0.18
READchr1193029393Silentrs375167412F143F0.25
READchr11930159683'UTRnovel0.8
READchr1193016377Missense_Mutationrs146351256A322T0.21
READchr11930599465'Flanknovel0.5
SARCchr11930161243'UTRnovel0.38
SKCMchr11930162833'UTRnovel0.21
SKCMchr1193029277Missense_MutationNAS156L0.26
SKCMchr1193049776SilentNAS72S0.15
SKCMchr11930163053'UTRnovel0.69
STADchr11930599195'Flanknovel0.18
STADchr1193049774Missense_MutationNAR73Q0.1
UCECchr11930161283'UTRnovel0.15
UCECchr1193028087Missense_MutationnovelQ209H0.21
UCECchr11930599625'Flanknovel0.3
UCECchr1193029558Nonsense_MutationNAE116*0.3
UCECchr1193051811Missense_Mutationrs770894191R28Q0.3
UCECchr1193049818Nonsense_MutationNAW58*0.14
UCECchr1193029285SilentnovelT153T0.29
UCECchr11930160203'UTRnovel0.44
UCECchr11930162103'UTRnovel0.27
UCECchr1193049764Silentrs200634415T76T0.28
UCECchr11930595165'Flanknovel0.23
UCECchr11930594335'UTRnovel0.25
UCECchr1193023926Missense_MutationnovelR217Q0.1
UCECchr1193016370Missense_MutationnovelK324T0.38
UCECchr1193020336Intronnovel0.28
UCECchr11930595075'Flanknovel0.19
UCECchr1193023876Frame_Shift_DelnovelQ233Dfs*200.11
UCECchr1193022992SilentNAI260I0.23
UCECchr1193029413Nonsense_MutationnovelR137*0.24
UCECchr1193028145Missense_MutationnovelA190V0.37
UCECchr1193018571Intronnovel0.38
UCECchr1193021114Missense_MutationnovelI310L0.24
UCECchr11930597325'Flanknovel0.36
UCECchr1193029544SilentnovelS120S0.4
UCECchr11930593455'UTRnovel0.27
UCECchr11930598115'Flanknovel0.2
UCECchr11930594235'UTRnovel0.09
UCECchr11930161793'UTRnovel0.31
UCECchr11930592635'UTRnovel0.38
UCECchr1193049840Missense_MutationnovelG51E0.5
UCECchr1193022960Missense_MutationNAI271T0.33
UCECchr1193022933Missense_MutationNAR280I0.25
UCECchr1193029197Nonsense_MutationnovelE183*0.09
UCECchr1193022942Missense_MutationnovelK277T0.08
UCECchr1193051771Missense_MutationnovelE41D0.16
UCECchr1193018612Intronnovel0.25
UCECchr11930599505'Flanknovel0.22
UCECchr11930597995'Flanknovel0.26
UCECchr11930599225'Flankrs3732913620.39
UCECchr1193022971Frame_Shift_InsnovelN267Kfs*60.36
UCECchr1193023922SilentNAF218F0.55
UCECchr1193018605Intronnovel0.62
UCECchr1193023905Missense_MutationnovelV224A0.27
UCECchr1193021111Missense_MutationnovelP311S0.09
UCECchr1193029285SilentnovelT153T0.64
UCECchr11930162483'UTRrs1841326250.39
UCECchr11930599025'Flanknovel0.38
UCSchr1193023926Missense_MutationnovelR217Q0.31

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
BLCADEL0.06860.033566
DLBCDEL0.04170.0017831
KIRCAMP0.08520.059566
PAADAMP0.21740.085665
READAMP0.26060.14328
TGCTAMP0.340.088103
THCAAMP0.05010.075436

Survival Analysis
CancerP-value Q-value
KIRC0.00079

Kaplan-Meier Survival Analysis

SARC0.041

Kaplan-Meier Survival Analysis

ACC0.00024

Kaplan-Meier Survival Analysis

SKCM0.035

Kaplan-Meier Survival Analysis

KIRP0.00022

Kaplan-Meier Survival Analysis

COAD0.044

Kaplan-Meier Survival Analysis

PAAD0.011

Kaplan-Meier Survival Analysis

CESC0.0061

Kaplan-Meier Survival Analysis

LAML0.021

Kaplan-Meier Survival Analysis

KICH0.0062

Kaplan-Meier Survival Analysis

UCEC0.0054

Kaplan-Meier Survival Analysis

LIHC0.017

Kaplan-Meier Survival Analysis

LGG0.003

Kaplan-Meier Survival Analysis

THCA0.004

Kaplan-Meier Survival Analysis

LUAD0.0013

Kaplan-Meier Survival Analysis

OV0.0063

Kaplan-Meier Survival Analysis

Drugs

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Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBPome
  • PRI
  • Expression
  • Transcripts
  • Gene Model
  • Phenotypes
  • GWAS
  • PPI
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000116750 (Gene tree)
Gene ID
51377
Gene Symbol
UCHL5
Alias
UCH37|CGI-70|INO80R
Full Name
ubiquitin C-terminal hydrolase L5
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Minus strand
Length
47,858 bases
Position
chr1:193,012,250-193,060,107
Accession
19678
RBP type
non-canonical RBP
Summary
(Ubiquitin C-Terminal Hydrolase L5) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Transcriptional activity of SMAD2/SMAD3-SMAD4 heterotrimer. Gene Ontology (GO) annotations related to this gene include endopeptidase inhibitor activity. An important paralog of this gene is BAP1.
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
29431736Capturing the interactome of newly transcribed RNARICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
22658674Insights into RNA biology from an atlas of mammalian mRNA-binding proteinsRIC & Hela2012 May 31Castello ADOI: 10.1016/j.cell.2012.04.031
27453046Comprehensive Identification of RNA-Binding Domains in Human CellsRIC & Hela2016 Aug 18Castello ADOI: 10.1016/j.molcel.2016.06.029
Protein-RNA interaction(RNA-Binding Site)
Click here to download all RNA binding sites
Click here to download all RNA binding sites
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000443327UCHL5-211785-ENSP00000391153183 (aa)-H0Y4E0
ENST00000367450UCHL5-2031355XM_006711370ENSP00000356420368 (aa)XP_006711433Q5LJA9
ENST00000367451UCHL5-2041346XM_017001439ENSP00000356421355 (aa)XP_016856928Q5LJA5
ENST00000449480UCHL5-212784-ENSP00000402847115 (aa)-H0Y636
ENST00000483156UCHL5-213417--- (aa)--
ENST00000367454UCHL5-2051815-ENSP00000356424328 (aa)-Q9Y5K5
ENST00000367455UCHL5-2065327XM_017001436ENSP00000356425329 (aa)XP_016856925Q9Y5K5
ENST00000367449UCHL5-2021507XM_006711369ENSP00000356419316 (aa)XP_006711432Q9Y5K5
ENST00000367448UCHL5-2011534XM_005245246ENSP00000356418326 (aa)XP_005245303Q9Y5K5
ENST00000421683UCHL5-210834-ENSP00000389563258 (aa)-Q5LJB0
ENST00000417752UCHL5-208577-ENSP00000412265165 (aa)-Q5LJB1
ENST00000416915UCHL5-207411-ENSP0000039241699 (aa)-H0Y4K0
ENST00000420791UCHL5-2091329XM_017001443ENSP00000408720218 (aa)XP_016856932H0Y6Y4
Gene Model
Click here to download ENSG00000116750's gene model file
Phenotypes
ensgIDTraitpValuePubmed ID
ENSG00000116750Marijuana Abuse5E-621668797
GWAS
ensgIDSNPChromosomePositionSNP-risk TraitPubmedID95% CIOr or BEAT EFO ID
ENSG00000116750rs94275731193026083?Cannabis dependence21668797[1.71-3.82]2.56EFO_0007191
ENSG00000116750rs109213041193022653?Body mass index30595370EFO_0004340
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000116750's network

* RBP PPI network refers to all genes directly bind to RBP
Orthologs identified by RBPome
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000116750UCHL59946.965WBGene00006724ubh-49247.284Caenorhabditis_elegans
ENSG00000116750UCHL510061.830FBgn0011327Uch-L59960.241Drosophila_melanogaster
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0003723RNA binding22658674.HDAFunction
GO:0004843thiol-dependent ubiquitin-specific protease activity21873635.IBAFunction
GO:0004843thiol-dependent ubiquitin-specific protease activity18922472.IDAFunction
GO:0004866endopeptidase inhibitor activity18162577.IMPFunction
GO:0005515protein binding11163772.16990800.17139257.18922472.19490896.19615732.21303910.21516116.25416956.IPIFunction
GO:0005634nucleus18922472.IDAComponent
GO:0005654nucleoplasm-IDAComponent
GO:0005654nucleoplasm-TASComponent
GO:0005737cytoplasm21873635.IBAComponent
GO:0005739mitochondrion-IDAComponent
GO:0005829cytosol18922472.IDAComponent
GO:0005829cytosol-TASComponent
GO:0006281DNA repair-IEAProcess
GO:0006310DNA recombination-IEAProcess
GO:0006511ubiquitin-dependent protein catabolic process-IEAProcess
GO:0010951negative regulation of endopeptidase activity-IEAProcess
GO:0016579protein deubiquitination21873635.IBAProcess
GO:0016579protein deubiquitination18922472.IDAProcess
GO:0016579protein deubiquitination-TASProcess
GO:0021670lateral ventricle development-IEAProcess
GO:0030901midbrain development-IEAProcess
GO:0031011Ino80 complex21303910.IDAComponent
GO:0031011Ino80 complex18922472.IDAComponent
GO:0031597cytosolic proteasome complex-IEAComponent
GO:0032435negative regulation of proteasomal ubiquitin-dependent protein catabolic process23770237.IMPProcess
GO:0048853forebrain morphogenesis-IEAProcess
GO:0061136regulation of proteasomal protein catabolic process18162577.IMPProcess
GO:0070628proteasome binding18162577.18922472.IDAFunction
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