EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
29436693	Yap regulates gastric cancer survival and migration via SIRT1/Mfn2/mitophagy.	Oncol Rep	2018 Apr	Yan H	doi: 10.3892/or.2018.6252
28176801	MFN2 suppresses cancer progression through inhibition of mTORC2/Akt signaling.	Sci Rep	2017 Feb 8	Xu K	doi: 10.1038/srep41718.
20803103	Anti-tumour efficacy of mitofusin-2 in urinary bladder carcinoma.	Med Oncol	2011 Dec	Jin B	doi: 10.1007/s12032-010-9662-5
24503793	Frequent losses of heterozygosity in the mitofusin 2 gene in hepatocellular carcinoma: their relationship to clinicopathological features.	Tumori	2013 Nov-Dec	Qu L	doi: 10.1700/1390.15458.
21190094	Pro-apoptotic and anti-proliferative effects of mitofusin-2 via Bax signaling in hepatocellular carcinoma cells.	Med Oncol	2012 Mar	Wang W	doi: 10.1007/s12032-010-9779-6
20936726	[Clinical significance of heterozygosity loss at Mfn2 gene in hepatocellular carcinoma].	Zhejiang Da Xue Xue Bao Yi Xue Ban	2010 Sep	Qu L	-
26446920	Sonic Hedgehog Signaling Drives Mitochondrial Fragmentation by Suppressing Mitofusins in Cerebellar Granule Neuron Precursors and Medulloblastoma.	Mol Cancer Res	2016 Jan	Malhotra A	doi: 10.1158/1541-7786.MCR-15-0278
20804729	Mitofusin-2 is a novel direct target of p53.	Biochem Biophys Res Commun	2010 Oct 1	Wang W	doi: 10.1016/j.bbrc.2010.08.108
29749475	miR-125a induces apoptosis, metabolism disorder and migrationimpairment in pancreatic cancer cells by targeting Mfn2-related mitochondrial fission.	Int J Oncol	2018 Jul	Pan L	doi: 10.3892/ijo.2018.4380
26888829	Mitochondrial Reprogramming Regulates Breast Cancer Progression.	Clin Cancer Res	2016 Jul 1	Kannan A	doi: 10.1158/1078-0432.CCR-15-2456
23906296	Cell-cycle arrest at G2/M and proliferation inhibition by adenovirus-expressed mitofusin-2 gene in human colorectal cancer cell lines.	Neoplasma	2013	Cheng X	doi: 10.4149/neo_2013_080.
23588792	Estrogen receptor β inhibits estradiol-induced proliferation and migration of MCF-7 cells through regulation of mitofusin 2.	Int J Oncol	2013 Jun	Ma L	doi: 10.3892/ijo.2013.1903
20654126	[Over expression of hyperplasia suppressor gene inhibits the malignant phenotype of breast cancer cell].	Zhonghua Bing Li Xue Za Zhi	2010 Apr	Zhang Y	-
20514460	HSG provides antitumor efficacy on hepatocellular carcinoma both in vitro and in vivo.	Oncol Rep	2010 Jul	Wang W	-
27364555	Metabolic Stress-Induced Phosphorylation of KAP1 Ser473 Blocks Mitochondrial Fusion in Breast Cancer Cells.	Cancer Res	2016 Sep 1	Cheng CT	doi: 10.1158/0008-5472.CAN-15-2921
29848692	Mitofusin-2 Expression Is Implicated in Cervical Cancer Pathogenesis.	Anticancer Res	2018 Jun	Ahn SY	doi: 10.21873/anticanres.12610.

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
BLCA	chr1	11996180	Silent	novel	V112V	0.23
BLCA	chr1	12005749	Missense_Mutation	NA	Q512E	0.21
BLCA	chr1	12001779	Silent	rs747677218	L327L	0.18
BLCA	chr1	12001834	Missense_Mutation	novel	E346Q	0.22
BLCA	chr1	12002044	Silent	novel	Q367Q	0.27
BLCA	chr1	11997303	Missense_Mutation	NA	N161D	0.93	MMR_HSR1
BLCA	chr1	12001514	Silent	NA	L310L	0.18
BLCA	chr1	12001823	Missense_Mutation	novel	E342V	0.06
BLCA	chr1	11989310	Missense_Mutation	novel	A48S	0.09
BLCA	chr1	12002093	Missense_Mutation	NA	R384G	0.21
BRCA	chr1	12005857	Missense_Mutation	rs373368672	G548R	0.14
BRCA	chr1	12004517	Silent	NA	T432T	0.15
BRCA	chr1	12007076	Silent	novel	R632R	0.09
BRCA	chr1	12001998	Missense_Mutation	NA	S352Y	0.5
BRCA	chr1	12011546	Missense_Mutation	novel	Y752F	0.06
BRCA	chr1	12005821	Missense_Mutation	novel	D536H	0.14
BRCA	chr1	11997359	Silent	novel	V179V	0.17
CESC	chr1	12011675	3'UTR	novel		0.44
CESC	chr1	12005743	Missense_Mutation	rs146092040	R510W	0.22
CESC	chr1	11992689	Missense_Mutation	rs119103268	R104W	0.31	MMR_HSR1
CESC	chr1	11989322	Missense_Mutation	NA	E52K	0.34
COAD	chr1	12013205	3'UTR	novel		0.25
COAD	chr1	11992679	Frame_Shift_Del	NA	*F102Lfs11**	0.41	MMR_HSR1
COAD	chr1	12007180	Missense_Mutation	NA	E667A	0.26
COAD	chr1	11999095	Missense_Mutation	novel	E272D	0.47
COAD	chr1	12013287	3'UTR	novel		0.11
COAD	chr1	12007116	Missense_Mutation	rs754683866	V646I	0.31
COAD	chr1	11996314	Missense_Mutation	NA	A157V	0.37	MMR_HSR1
COAD	chr1	11992679	Frame_Shift_Del	NA	*F102Lfs11**	0.25	MMR_HSR1
COAD	chr1	12013226	3'UTR	novel		0.2
COAD	chr1	12011628	3'UTR	novel		0.42
COAD	chr1	11992679	Frame_Shift_Del	NA	*F102Lfs11**	0.1	MMR_HSR1
COAD	chr1	12007156	Missense_Mutation	novel	R659M	0.18
COAD	chr1	12001497	Missense_Mutation	novel	S305P	0.12
COAD	chr1	11992679	Frame_Shift_Del	NA	*F102Lfs11**	0.27	MMR_HSR1
COAD	chr1	11996210	Silent	novel	L122L	0.12
COAD	chr1	11989254	Missense_Mutation	novel	L29P	0.1
ESCA	chr1	12001777	Missense_Mutation	novel	L327V	0.08
ESCA	chr1	12002058	Missense_Mutation	novel	V372D	0.28
ESCA	chr1	12004000	Missense_Mutation	novel	C390Y	0.23
ESCA	chr1	12013226	3'UTR	novel		0.64
ESCA	chr1	11996215	Missense_Mutation	novel	S124C	0.63	MMR_HSR1
GBM	chr1	11997355	Missense_Mutation	novel	L178P	0.16	MMR_HSR1
GBM	chr1	12001465	Missense_Mutation	rs371982971	R294Q	0.56
GBM	chr1	12011589	3'UTR	rs763630899		0.19
HNSC	chr1	11996289	Missense_Mutation	rs754016178	E149K	0.1	MMR_HSR1
HNSC	chr1	12002056	Silent	rs766570486	A371A	0.34
HNSC	chr1	12004921	Missense_Mutation	novel	M497V	0.58
HNSC	chr1	12001454	Silent	rs368302487	G290G	0.1
HNSC	chr1	12007090	Missense_Mutation	novel	S637F	0.03
HNSC	chr1	12007091	Silent	novel	S637S	0.03
HNSC	chr1	12007168	Missense_Mutation	rs766735605	R663L	0.25
HNSC	chr1	12004099	Missense_Mutation	rs8192303	T423M	0.48
KIRP	chr1	12001491	Frame_Shift_Del	novel	*F303Cfs4**	0.63
KIRP	chr1	11992609	Frame_Shift_Del	novel	*D77Gfs13**	0.36
KIRP	chr1	11992657	Missense_Mutation	novel	A93V	0.19
LAML	chr1	12005853	Silent	novel	S546S	0.11
LGG	chr1	12011526	Silent	NA	L745L	0.38
LGG	chr1	11996187	Missense_Mutation	novel	A115T	0.44	MMR_HSR1
LIHC	chr1	12009650	Missense_Mutation	NA	L710V	0.14
LUAD	chr1	12005833	Missense_Mutation	NA	D540H	0.21
LUAD	chr1	11998849	Missense_Mutation	NA	A227T	0.48	MMR_HSR1
LUAD	chr1	12009725	Splice_Region	NA	R735R	0.11
LUAD	chr1	11999004	Missense_Mutation	novel	H242L	0.15	MMR_HSR1
LUAD	chr1	12006536	Splice_Site	novel	X573_splice	0.26
LUAD	chr1	12001470	Nonsense_Mutation	NA	Q296*	0.2
LUAD	chr1	11989213	Missense_Mutation	novel	K15N	0.22
LUAD	chr1	12004868	Missense_Mutation	novel	S479C	0.28
LUAD	chr1	12011625	3'UTR	novel		0.33
LUSC	chr1	12006630	Missense_Mutation	novel	M603I	0.36
LUSC	chr1	12011524	Missense_Mutation	novel	L745F	0.38
LUSC	chr1	11996253	Nonsense_Mutation	novel	E137*	0.33	MMR_HSR1
LUSC	chr1	12011589	3'UTR	novel		0.09
OV	chr1	11996230	Missense_Mutation	novel	T129S	0.15	MMR_HSR1
OV	chr1	12005909	Missense_Mutation	novel	A565G	0.12
OV	chr1	12005781	Silent	novel	F522F	0.16
OV	chr1	12005786	Missense_Mutation	novel	L524R	0.2
OV	chr1	12005905	Missense_Mutation	rs545454816	R564W	0.19
OV	chr1	12001772	Missense_Mutation	novel	G325A	0.04
OV	chr1	12007057	Missense_Mutation	NA	W626L	0.15
OV	chr1	12002048	Missense_Mutation	novel	A369S	0.1
OV	chr1	11989241	Missense_Mutation	novel	N25D	0.03
OV	chr1	12005878	Missense_Mutation	novel	R555W	0.09
OV	chr1	12005770	Missense_Mutation	novel	R519S	0.03
OV	chr1	12004021	Missense_Mutation	rs778219078	R397Q	0.75
PAAD	chr1	11992639	Missense_Mutation	novel	G87D	0.18
PRAD	chr1	11992649	Silent	NA	E90E	0.24
PRAD	chr1	11998880	Splice_Site	NA	X236_splice	0.11
PRAD	chr1	11998828	Missense_Mutation	novel	A220S	0.11	MMR_HSR1
PRAD	chr1	11989188	Missense_Mutation	novel	R7Q	0.57
READ	chr1	12005841	Silent	NA	E542E	0.53
SKCM	chr1	12011659	3'UTR	novel		0.15
SKCM	chr1	12006648	Silent	rs138724074	S609S	0.55
SKCM	chr1	11997419	Splice_Region	NA	D199D	0.2
SKCM	chr1	12006552	Silent	NA	I577I	0.18
SKCM	chr1	12002032	Silent	NA	V363V	0.11
STAD	chr1	12001773	Silent	rs141475476	G325G	0.2
STAD	chr1	12007115	Silent	rs752881611	Y645Y	0.38
STAD	chr1	11992648	Missense_Mutation	NA	E90G	0.21
STAD	chr1	12001483	Missense_Mutation	NA	R300H	0.24
STAD	chr1	11997390	Missense_Mutation	novel	L190I	0.06	MMR_HSR1
STAD	chr1	11999082	Missense_Mutation	NA	E268A	0.24
STAD	chr1	12011600	3'UTR	rs369206304		0.12
STAD	chr1	12002060	Nonsense_Mutation	NA	R373*	0.24
STAD	chr1	11999055	Missense_Mutation	rs755065651	R259H	0.06
STAD	chr1	12009709	Missense_Mutation	NA	S729R	0.06
STAD	chr1	11989163	Splice_Site	NA		0.09
STAD	chr1	11998796	Missense_Mutation	NA	L209P	0.14	MMR_HSR1
STAD	chr1	11997337	Missense_Mutation	NA	Q172R	0.09	MMR_HSR1
STAD	chr1	12005906	Missense_Mutation	rs746213217	R564Q	0.26
STAD	chr1	11992687	Missense_Mutation	NA	G103V	0.15	MMR_HSR1
THCA	chr1	11997303	Missense_Mutation	NA	N161D	0.08	MMR_HSR1
UCEC	chr1	12005826	Silent	novel	F537F	0.08
UCEC	chr1	12006566	Missense_Mutation	novel	A582V	0.3
UCEC	chr1	12007231	Missense_Mutation	NA	C684Y	0.09
UCEC	chr1	11992595	Silent	novel	E72E	0.38
UCEC	chr1	12004020	Missense_Mutation	rs758948968	R397W	0.43
UCEC	chr1	12009651	Missense_Mutation	NA	L710P	0.42
UCEC	chr1	12001522	Missense_Mutation	novel	R313K	0.17
UCEC	chr1	12006581	Missense_Mutation	novel	P587L	0.14
UCEC	chr1	12013467	3'UTR	novel		0.26
UCEC	chr1	11996294	Frame_Shift_Del	NA	*S151Qfs10**	0.39	MMR_HSR1
UCEC	chr1	11996193	Missense_Mutation	NA	L117I	0.21	MMR_HSR1
UCEC	chr1	11997379	Missense_Mutation	NA	S186Y	0.19	MMR_HSR1
UCEC	chr1	12004083	Nonsense_Mutation	NA	R418*	0.23
UCEC	chr1	12006694	Splice_Site	novel	X624_splice	0.17
UCEC	chr1	12011579	3'UTR	rs369188276		0.12
UCEC	chr1	12011654	3'UTR	novel		0.23
UCEC	chr1	11996223	Missense_Mutation	NA	G127S	0.42	MMR_HSR1
UCEC	chr1	12013263	3'UTR	novel		0.48
UCEC	chr1	11998879	Splice_Site	novel	X236_splice	0.47
UCEC	chr1	12007115	Silent	rs752881611	Y645Y	0.19
UCEC	chr1	12011589	3'UTR	rs763630899		0.23
UCEC	chr1	11992678	Frame_Shift_Ins	rs777012596	*G103Wfs41**	0.26	MMR_HSR1
UCEC	chr1	12006662	Missense_Mutation	novel	T614N	0.38
UCEC	chr1	11989244	Missense_Mutation	novel	A26T	0.27
UCEC	chr1	11996244	Missense_Mutation	novel	L134M	0.36	MMR_HSR1
UCEC	chr1	12011583	3'UTR	novel		0.36
UCEC	chr1	12007110	Missense_Mutation	novel	L644I	0.55
UCEC	chr1	12006653	Missense_Mutation	NA	T611I	0.32
UCEC	chr1	12011833	3'UTR	novel		0.53
UCEC	chr1	12013263	3'UTR	novel		0.18
UCEC	chr1	12006544	Missense_Mutation	rs786204244	R575C	0.42
UCEC	chr1	11992679	Frame_Shift_Del	NA	*F102Lfs11**	0.22	MMR_HSR1
UCEC	chr1	12002055	Missense_Mutation	rs201675158	A371V	0.22
UCEC	chr1	12005785	Missense_Mutation	novel	L524I	0.28
UCEC	chr1	12013350	3'UTR	novel		0.15
UCEC	chr1	12001475	Silent	rs11554508	A297A	0.32
UCEC	chr1	12011588	3'UTR	rs762707869		0.4
UCEC	chr1	12001780	Missense_Mutation	novel	A328T	0.33
UCEC	chr1	12004084	Missense_Mutation	rs766998571	R418Q	0.51
UCEC	chr1	11989202	Missense_Mutation	rs367715413	V12I	0.23
UCEC	chr1	12001479	Missense_Mutation	novel	D299Y	0.33
UCEC	chr1	12002030	Missense_Mutation	novel	V363I	0.27
UCEC	chr1	12013319	3'UTR	novel		0.39
UCEC	chr1	11999078	Missense_Mutation	novel	P267S	0.31
UCEC	chr1	12004527	Missense_Mutation	NA	E436K	0.35
UCEC	chr1	12004559	Silent	rs376300393	D446D	0.41
UCEC	chr1	11999018	Missense_Mutation	rs369948853	R247C	0.24	MMR_HSR1

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
CESC	DEL	0.1119	0.00029523
CHOL	DEL	0.8056	3.3987e-23
DLBC	DEL	0.0833	0.011841
HNSC	DEL	0.1379	7.0766e-07
KIRC	DEL	0.1439	2.3538e-09
KIRP	DEL	0.1736	1.462e-09
LUAD	DEL	0.1434	0.0024765
LUSC	DEL	0.3633	2.5882e-07
MESO	DEL	0.3333	2.434e-07
READ	DEL	0.3879	2.1758e-10
TGCT	DEL	0.18	0.00046313
UCS	DEL	0.2857	0.0051125

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.0001	Kaplan-Meier Survival Analysis
SARC	0.038	Kaplan-Meier Survival Analysis
MESO	0.015	Kaplan-Meier Survival Analysis
KIRP	0.0028	Kaplan-Meier Survival Analysis
LAML	0.018	Kaplan-Meier Survival Analysis
KICH	0.032	Kaplan-Meier Survival Analysis
UCEC	0.048	Kaplan-Meier Survival Analysis
LGG	0.012	Kaplan-Meier Survival Analysis
LUAD	0.044	Kaplan-Meier Survival Analysis
OV	0.022	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBDs

Expression

Transcripts

Gene Model

Pathway

Phenotype

GWAS

PPI

Ortholog

Gene Ontology

Description

Ensembl ID: ENSG00000116688 (Gene tree)
Gene ID: 9927
Gene Symbol: MFN2
Alias: CPRP1|KIAA0214|MARF|CMT2A2
Full Name: mitofusin 2
Gene Type: protein_coding
Specie: Homo_sapiens
Strand: Plus strand
Length: 33,335 bases
Position: chr1:11,980,181-12,013,515
Accession: 16877
Summary: This gene encodes a mitochondrial membrane protein that participates in mitochondrial fusion and contributes to the maintenance and operation of the mitochondrial network. This protein is involved in the regulation of vascular smooth muscle cell proliferation, and it may play a role in the pathophysiology of obesity. Mutations in this gene cause Charcot-Marie-Tooth disease type 2A2, and hereditary motor and sensory neuropathy VI, which are both disorders of the peripheral nervous system. Defects in this gene have also been associated with early-onset stroke. Two transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000235329	MMR_HSR1	PF01926.23	7.8e-07	1	1
ENSP00000416338	MMR_HSR1	PF01926.23	7.8e-07	1	1

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000444836	MFN2-203	4531	-	ENSP00000416338	757 (aa)	-	O95140
ENST00000490079	MFN2-205	445	-	-	- (aa)	-	-
ENST00000497302	MFN2-206	645	-	-	- (aa)	-	-
ENST00000235329	MFN2-201	4539	XM_005263543	ENSP00000235329	757 (aa)	XP_005263600	O95140
ENST00000412236	MFN2-202	489	-	ENSP00000412023	98 (aa)	-	Q5JXC5
ENST00000484391	MFN2-204	294	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000116688's gene model file

Pathway

Pathway ID	Pathway Name	Source
hsa04137	Mitophagy - animal	KEGG
hsa04621	NOD-like receptor signaling pathway	KEGG

Phenotype

ensgID	Trait	pValue	Pubmed ID
ENSG00000116688	Myocardial Infarction	8.9703528E-004	-
ENSG00000116688	Platelet Count	1E-8	22139419
ENSG00000116688	Dermatitis, Atopic	1E-6	25574825

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000116688	rs6686734	1	12008884	?	Inflammatory skin disease	25574825			EFO_0000274
ENSG00000116688	rs2336384	1	11986006	G	Platelet count	22139419	[1.42-2.92] 10^9/l increase	2.172	EFO_0004309
ENSG00000116688	rs4240897	1	11982698	?	Tuberculosis	29036319	[1.20-1.33]	1.27	Orphanet_3389
ENSG00000116688	rs730123	1	12010235	?	Plasma homocysteine levels	30339177	[0.013-0.026] ?mol/L increase	0.01915	EFO_0004578

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000116688's network

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy	Species
ENSG00000116688	MFN2	80	41.026	ENSAPOG00000022283	-	98	67.178	Acanthochromis_polyacanthus
ENSG00000116688	MFN2	96	64.865	ENSAPOG00000019846	mfn1b	98	65.309	Acanthochromis_polyacanthus
ENSG00000116688	MFN2	99	77.441	ENSAPOG00000017591	mfn2	99	77.968	Acanthochromis_polyacanthus
ENSG00000116688	MFN2	97	65.765	ENSAMEG00000010816	MFN1	96	65.765	Ailuropoda_melanoleuca
ENSG00000116688	MFN2	100	97.959	ENSAMEG00000010033	MFN2	98	96.974	Ailuropoda_melanoleuca
ENSG00000116688	MFN2	97	81.030	ENSACIG00000013827	mfn2	100	81.030	Amphilophus_citrinellus
ENSG00000116688	MFN2	86	64.795	ENSACIG00000012823	mfn1b	99	64.795	Amphilophus_citrinellus
ENSG00000116688	MFN2	99	83.820	ENSAOCG00000007392	mfn2	99	83.820	Amphiprion_ocellaris
ENSG00000116688	MFN2	96	65.116	ENSAOCG00000008499	mfn1b	99	65.116	Amphiprion_ocellaris
ENSG00000116688	MFN2	99	83.820	ENSAPEG00000014888	mfn2	99	83.820	Amphiprion_percula
ENSG00000116688	MFN2	96	64.865	ENSAPEG00000005600	mfn1b	97	64.865	Amphiprion_percula
ENSG00000116688	MFN2	92	55.091	ENSAPEG00000002172	-	97	55.804	Amphiprion_percula
ENSG00000116688	MFN2	97	55.450	ENSATEG00000004500	-	99	55.450	Anabas_testudineus
ENSG00000116688	MFN2	97	65.217	ENSATEG00000009967	mfn1b	99	65.217	Anabas_testudineus
ENSG00000116688	MFN2	100	81.662	ENSATEG00000024839	mfn2	100	81.662	Anabas_testudineus
ENSG00000116688	MFN2	98	66.935	ENSAPLG00000012500	MFN1	100	66.935	Anas_platyrhynchos
ENSG00000116688	MFN2	98	90.701	ENSAPLG00000012438	MFN2	100	90.701	Anas_platyrhynchos
ENSG00000116688	MFN2	97	65.761	ENSACAG00000004702	MFN1	99	65.761	Anolis_carolinensis
ENSG00000116688	MFN2	100	99.207	ENSANAG00000025746	MFN2	100	99.207	Aotus_nancymaae
ENSG00000116688	MFN2	97	63.194	ENSANAG00000032522	MFN1	99	63.194	Aotus_nancymaae
ENSG00000116688	MFN2	97	55.177	ENSACLG00000017694	-	99	55.177	Astatotilapia_calliptera
ENSG00000116688	MFN2	96	64.169	ENSACLG00000019301	mfn1b	99	64.169	Astatotilapia_calliptera
ENSG00000116688	MFN2	100	82.082	ENSACLG00000004451	mfn2	100	82.082	Astatotilapia_calliptera
ENSG00000116688	MFN2	99	83.600	ENSAMXG00000014050	mfn2	97	83.600	Astyanax_mexicanus
ENSG00000116688	MFN2	97	58.254	ENSAMXG00000037049	-	99	58.254	Astyanax_mexicanus
ENSG00000116688	MFN2	97	64.973	ENSAMXG00000020170	mfn1b	99	64.973	Astyanax_mexicanus
ENSG00000116688	MFN2	100	97.959	ENSBTAG00000005314	MFN2	100	96.830	Bos_taurus
ENSG00000116688	MFN2	97	66.081	ENSBTAG00000010485	MFN1	99	66.081	Bos_taurus
ENSG00000116688	MFN2	98	35.686	WBGene00001509	fzo-1	96	35.686	Caenorhabditis_elegans
ENSG00000116688	MFN2	94	63.510	ENSCJAG00000013155	MFN1	99	63.510	Callithrix_jacchus
ENSG00000116688	MFN2	100	98.980	ENSCJAG00000013494	MFN2	99	99.470	Callithrix_jacchus
ENSG00000116688	MFN2	100	97.959	ENSCAFG00000016472	MFN2	100	97.358	Canis_familiaris
ENSG00000116688	MFN2	99	65.046	ENSCAFG00000011308	MFN1	99	66.035	Canis_familiaris
ENSG00000116688	MFN2	100	97.959	ENSCAFG00020009106	MFN2	100	97.226	Canis_lupus_dingo
ENSG00000116688	MFN2	97	66.035	ENSCAFG00020023114	MFN1	99	66.035	Canis_lupus_dingo
ENSG00000116688	MFN2	100	97.959	ENSCHIG00000016424	MFN2	100	96.301	Capra_hircus
ENSG00000116688	MFN2	99	65.113	ENSCHIG00000021326	MFN1	99	66.081	Capra_hircus
ENSG00000116688	MFN2	100	97.094	ENSTSYG00000004567	MFN2	100	97.094	Carlito_syrichta
ENSG00000116688	MFN2	97	66.035	ENSTSYG00000002404	MFN1	99	66.035	Carlito_syrichta
ENSG00000116688	MFN2	100	96.939	ENSCAPG00000006585	MFN2	100	96.565	Cavia_aperea
ENSG00000116688	MFN2	100	96.939	ENSCPOG00000006834	MFN2	100	96.565	Cavia_porcellus
ENSG00000116688	MFN2	97	64.547	ENSCPOG00000033188	MFN1	100	64.547	Cavia_porcellus
ENSG00000116688	MFN2	100	99.472	ENSCCAG00000026866	MFN2	100	99.472	Cebus_capucinus
ENSG00000116688	MFN2	97	63.194	ENSCCAG00000021450	MFN1	99	63.194	Cebus_capucinus
ENSG00000116688	MFN2	97	64.276	ENSCATG00000033458	MFN1	99	64.276	Cercocebus_atys
ENSG00000116688	MFN2	100	99.604	ENSCATG00000029203	MFN2	100	99.604	Cercocebus_atys
ENSG00000116688	MFN2	100	96.939	ENSCLAG00000009293	MFN2	100	96.697	Chinchilla_lanigera
ENSG00000116688	MFN2	97	64.276	ENSCSAG00000012988	MFN1	99	64.276	Chlorocebus_sabaeus
ENSG00000116688	MFN2	100	99.604	ENSCSAG00000000806	MFN2	100	99.604	Chlorocebus_sabaeus
ENSG00000116688	MFN2	97	67.027	ENSCPBG00000026929	MFN1	100	67.027	Chrysemys_picta_bellii
ENSG00000116688	MFN2	100	92.602	ENSCPBG00000021952	MFN2	100	92.602	Chrysemys_picta_bellii
ENSG00000116688	MFN2	99	51.706	ENSCING00000006787	-	99	51.706	Ciona_intestinalis
ENSG00000116688	MFN2	97	51.915	ENSCSAVG00000010593	-	99	52.048	Ciona_savignyi
ENSG00000116688	MFN2	89	65.676	ENSCANG00000034448	MFN1	96	65.676	Colobus_angolensis_palliatus
ENSG00000116688	MFN2	100	97.959	ENSCANG00000029188	MFN2	100	99.225	Colobus_angolensis_palliatus
ENSG00000116688	MFN2	100	96.939	ENSCGRG00001012340	Mfn2	100	96.037	Cricetulus_griseus_chok1gshd
ENSG00000116688	MFN2	97	65.041	ENSCGRG00001022585	-	99	65.223	Cricetulus_griseus_chok1gshd
ENSG00000116688	MFN2	100	96.939	ENSCGRG00000017227	Mfn2	100	96.037	Cricetulus_griseus_crigri
ENSG00000116688	MFN2	97	65.176	ENSCGRG00000014684	Mfn1	99	65.359	Cricetulus_griseus_crigri
ENSG00000116688	MFN2	100	82.718	ENSCSEG00000004648	mfn2	100	82.718	Cynoglossus_semilaevis
ENSG00000116688	MFN2	97	62.450	ENSCSEG00000013502	mfn1b	98	62.450	Cynoglossus_semilaevis
ENSG00000116688	MFN2	96	63.144	ENSCVAG00000007548	mfn1b	97	63.415	Cyprinodon_variegatus
ENSG00000116688	MFN2	98	81.696	ENSCVAG00000011379	mfn2	97	81.696	Cyprinodon_variegatus
ENSG00000116688	MFN2	80	39.744	ENSCVAG00000003530	-	94	60.131	Cyprinodon_variegatus
ENSG00000116688	MFN2	100	82.959	ENSDARG00000079504	mfn2	100	82.959	Danio_rerio
ENSG00000116688	MFN2	80	44.872	ENSDARG00000011884	MFN1	95	64.734	Danio_rerio
ENSG00000116688	MFN2	97	64.295	ENSDARG00000079219	mfn1b	99	71.091	Danio_rerio
ENSG00000116688	MFN2	97	65.223	ENSDNOG00000000527	MFN1	99	65.223	Dasypus_novemcinctus
ENSG00000116688	MFN2	100	96.939	ENSDNOG00000012602	MFN2	100	96.565	Dasypus_novemcinctus
ENSG00000116688	MFN2	97	65.265	ENSDORG00000016388	Mfn1	99	65.265	Dipodomys_ordii
ENSG00000116688	MFN2	96	34.730	FBgn0011596	fzo	98	34.487	Drosophila_melanogaster
ENSG00000116688	MFN2	97	47.200	FBgn0029870	Marf	92	46.950	Drosophila_melanogaster
ENSG00000116688	MFN2	75	71.150	ENSETEG00000015404	MFN1	78	71.150	Echinops_telfairi
ENSG00000116688	MFN2	97	65.765	ENSEASG00005016871	MFN1	99	65.765	Equus_asinus_asinus
ENSG00000116688	MFN2	100	97.959	ENSEASG00005016485	MFN2	100	97.226	Equus_asinus_asinus
ENSG00000116688	MFN2	97	66.035	ENSECAG00000018551	MFN1	99	66.035	Equus_caballus
ENSG00000116688	MFN2	100	96.962	ENSECAG00000016296	MFN2	100	96.962	Equus_caballus
ENSG00000116688	MFN2	92	65.571	ENSEEUG00000001400	MFN1	99	65.571	Erinaceus_europaeus
ENSG00000116688	MFN2	100	78.571	ENSELUG00000005449	mfn2	100	78.232	Esox_lucius
ENSG00000116688	MFN2	97	62.803	ENSELUG00000004472	mfn1b	99	63.686	Esox_lucius
ENSG00000116688	MFN2	97	57.162	ENSELUG00000016789	MFN1	99	57.162	Esox_lucius
ENSG00000116688	MFN2	100	97.959	ENSFCAG00000000076	MFN2	100	97.094	Felis_catus
ENSG00000116688	MFN2	97	65.629	ENSFCAG00000028181	MFN1	99	65.629	Felis_catus
ENSG00000116688	MFN2	100	91.149	ENSFALG00000010006	MFN2	100	91.149	Ficedula_albicollis
ENSG00000116688	MFN2	97	65.676	ENSFALG00000008386	MFN1	100	65.676	Ficedula_albicollis
ENSG00000116688	MFN2	100	97.959	ENSFDAG00000016534	MFN2	100	94.882	Fukomys_damarensis
ENSG00000116688	MFN2	80	56.410	ENSFDAG00000007656	-	100	74.583	Fukomys_damarensis
ENSG00000116688	MFN2	100	80.871	ENSFHEG00000011338	mfn2	100	80.871	Fundulus_heteroclitus
ENSG00000116688	MFN2	96	63.329	ENSFHEG00000007621	mfn1b	99	64.894	Fundulus_heteroclitus
ENSG00000116688	MFN2	97	62.988	ENSGMOG00000017233	mfn1b	98	63.686	Gadus_morhua
ENSG00000116688	MFN2	100	83.245	ENSGMOG00000003331	mfn2	100	83.245	Gadus_morhua
ENSG00000116688	MFN2	96	54.595	ENSGMOG00000002749	-	99	54.422	Gadus_morhua
ENSG00000116688	MFN2	98	91.544	ENSGALG00000004523	MFN2	98	91.544	Gallus_gallus
ENSG00000116688	MFN2	97	67.162	ENSGALG00000041873	MFN1	100	67.162	Gallus_gallus
ENSG00000116688	MFN2	98	80.754	ENSGAFG00000014901	mfn2	98	80.754	Gambusia_affinis
ENSG00000116688	MFN2	96	63.636	ENSGAFG00000013361	mfn1b	97	63.636	Gambusia_affinis
ENSG00000116688	MFN2	97	54.939	ENSGACG00000001587	-	93	65.946	Gasterosteus_aculeatus
ENSG00000116688	MFN2	100	82.982	ENSGACG00000012833	mfn2	100	82.982	Gasterosteus_aculeatus
ENSG00000116688	MFN2	96	64.578	ENSGACG00000009857	mfn1b	97	64.578	Gasterosteus_aculeatus
ENSG00000116688	MFN2	100	93.131	ENSGAGG00000016388	MFN2	100	93.131	Gopherus_agassizii
ENSG00000116688	MFN2	97	67.028	ENSGAGG00000016465	MFN1	99	67.028	Gopherus_agassizii
ENSG00000116688	MFN2	97	63.415	ENSGGOG00000009357	MFN1	99	63.735	Gorilla_gorilla
ENSG00000116688	MFN2	100	99.736	ENSGGOG00000005237	MFN2	100	99.736	Gorilla_gorilla
ENSG00000116688	MFN2	100	82.082	ENSHBUG00000004438	mfn2	100	82.082	Haplochromis_burtoni
ENSG00000116688	MFN2	97	63.784	ENSHBUG00000022434	mfn1b	99	63.784	Haplochromis_burtoni
ENSG00000116688	MFN2	100	96.939	ENSHGLG00000011663	MFN2	100	96.565	Heterocephalus_glaber_female
ENSG00000116688	MFN2	97	65.761	ENSHGLG00000012515	MFN1	99	65.761	Heterocephalus_glaber_female
ENSG00000116688	MFN2	100	96.939	ENSHGLG00100012457	MFN2	100	96.433	Heterocephalus_glaber_male
ENSG00000116688	MFN2	97	65.761	ENSHGLG00100011812	MFN1	99	65.761	Heterocephalus_glaber_male
ENSG00000116688	MFN2	96	63.194	ENSHCOG00000018858	mfn1b	97	63.194	Hippocampus_comes
ENSG00000116688	MFN2	100	81.794	ENSHCOG00000013229	mfn2	100	81.794	Hippocampus_comes
ENSG00000116688	MFN2	100	82.959	ENSIPUG00000020537	mfn2	100	82.959	Ictalurus_punctatus
ENSG00000116688	MFN2	97	64.219	ENSIPUG00000021322	mfn1b	99	64.352	Ictalurus_punctatus
ENSG00000116688	MFN2	97	65.900	ENSSTOG00000005167	MFN1	99	65.900	Ictidomys_tridecemlineatus
ENSG00000116688	MFN2	100	97.959	ENSSTOG00000005705	MFN2	100	97.226	Ictidomys_tridecemlineatus
ENSG00000116688	MFN2	97	65.088	ENSJJAG00000019731	Mfn1	99	65.088	Jaculus_jaculus
ENSG00000116688	MFN2	100	97.959	ENSJJAG00000012023	Mfn2	100	95.905	Jaculus_jaculus
ENSG00000116688	MFN2	96	65.494	ENSKMAG00000022004	mfn1b	97	65.494	Kryptolebias_marmoratus
ENSG00000116688	MFN2	80	84.615	ENSKMAG00000013699	-	92	80.421	Kryptolebias_marmoratus
ENSG00000116688	MFN2	97	53.061	ENSLBEG00000013155	-	96	66.964	Labrus_bergylta
ENSG00000116688	MFN2	87	65.309	ENSLBEG00000027183	-	99	65.309	Labrus_bergylta
ENSG00000116688	MFN2	100	84.037	ENSLBEG00000012337	mfn2	100	84.037	Labrus_bergylta
ENSG00000116688	MFN2	96	62.873	ENSLACG00000015275	MFN1	99	64.106	Latimeria_chalumnae
ENSG00000116688	MFN2	100	85.073	ENSLACG00000005172	MFN2	100	85.073	Latimeria_chalumnae
ENSG00000116688	MFN2	100	84.148	ENSLOCG00000005375	mfn2	100	84.148	Lepisosteus_oculatus
ENSG00000116688	MFN2	86	66.161	ENSLOCG00000001195	mfn1b	99	66.161	Lepisosteus_oculatus
ENSG00000116688	MFN2	97	64.276	ENSLAFG00000008856	MFN1	99	64.276	Loxodonta_africana
ENSG00000116688	MFN2	100	97.959	ENSLAFG00000000377	MFN2	100	97.094	Loxodonta_africana
ENSG00000116688	MFN2	100	99.604	ENSMFAG00000045034	MFN2	100	99.604	Macaca_fascicularis
ENSG00000116688	MFN2	97	64.276	ENSMFAG00000003857	MFN1	99	64.276	Macaca_fascicularis
ENSG00000116688	MFN2	100	99.604	ENSMMUG00000023449	MFN2	100	99.604	Macaca_mulatta
ENSG00000116688	MFN2	90	65.396	ENSMMUG00000004079	MFN1	99	65.396	Macaca_mulatta
ENSG00000116688	MFN2	100	99.339	ENSMNEG00000044766	MFN2	100	99.339	Macaca_nemestrina
ENSG00000116688	MFN2	97	64.276	ENSMLEG00000033980	MFN1	99	64.276	Mandrillus_leucophaeus
ENSG00000116688	MFN2	96	63.186	ENSMAMG00000005965	mfn1b	98	63.186	Mastacembelus_armatus
ENSG00000116688	MFN2	97	56.403	ENSMAMG00000018955	-	99	66.403	Mastacembelus_armatus
ENSG00000116688	MFN2	100	82.718	ENSMAMG00000008508	mfn2	100	82.718	Mastacembelus_armatus
ENSG00000116688	MFN2	96	63.784	ENSMZEG00005002022	mfn1b	97	63.784	Maylandia_zebra
ENSG00000116688	MFN2	100	82.082	ENSMZEG00005018589	mfn2	100	82.082	Maylandia_zebra
ENSG00000116688	MFN2	100	91.413	ENSMGAG00000006053	MFN2	100	91.413	Meleagris_gallopavo
ENSG00000116688	MFN2	100	96.939	ENSMAUG00000008664	Mfn2	100	95.641	Mesocricetus_auratus
ENSG00000116688	MFN2	97	64.905	ENSMAUG00000010778	Mfn1	99	65.088	Mesocricetus_auratus
ENSG00000116688	MFN2	97	65.395	ENSMICG00000049257	MFN1	99	65.395	Microcebus_murinus
ENSG00000116688	MFN2	100	97.959	ENSMICG00000002730	MFN2	100	97.490	Microcebus_murinus
ENSG00000116688	MFN2	97	66.035	ENSMOCG00000019248	Mfn1	99	66.035	Microtus_ochrogaster
ENSG00000116688	MFN2	100	96.939	ENSMOCG00000018675	Mfn2	100	96.433	Microtus_ochrogaster
ENSG00000116688	MFN2	96	63.711	ENSMMOG00000019533	mfn1b	98	63.711	Mola_mola
ENSG00000116688	MFN2	97	83.582	ENSMMOG00000017522	mfn2	100	83.582	Mola_mola
ENSG00000116688	MFN2	97	66.081	ENSMODG00000021304	MFN1	99	66.081	Monodelphis_domestica
ENSG00000116688	MFN2	100	92.338	ENSMODG00000010801	MFN2	100	92.338	Monodelphis_domestica
ENSG00000116688	MFN2	97	64.402	ENSMALG00000017449	mfn1b	99	64.402	Monopterus_albus
ENSG00000116688	MFN2	100	82.850	ENSMALG00000000047	mfn2	100	82.850	Monopterus_albus
ENSG00000116688	MFN2	100	95.918	MGP_CAROLIEiJ_G0026785	Mfn2	100	95.244	Mus_caroli
ENSG00000116688	MFN2	80	52.564	MGP_CAROLIEiJ_G0024918	-	100	72.917	Mus_caroli
ENSG00000116688	MFN2	97	65.765	ENSMUSG00000027668	Mfn1	100	73.750	Mus_musculus
ENSG00000116688	MFN2	100	95.918	ENSMUSG00000029020	Mfn2	100	94.980	Mus_musculus
ENSG00000116688	MFN2	100	95.918	MGP_PahariEiJ_G0029133	Mfn2	100	94.980	Mus_pahari
ENSG00000116688	MFN2	97	65.223	MGP_PahariEiJ_G0026363	Mfn1	100	73.750	Mus_pahari
ENSG00000116688	MFN2	97	65.765	MGP_SPRETEiJ_G0025852	Mfn1	100	73.750	Mus_spretus
ENSG00000116688	MFN2	100	95.918	MGP_SPRETEiJ_G0027778	Mfn2	100	95.244	Mus_spretus
ENSG00000116688	MFN2	100	97.959	ENSMPUG00000016388	MFN2	100	96.565	Mustela_putorius_furo
ENSG00000116688	MFN2	97	66.035	ENSMPUG00000017210	MFN1	99	66.035	Mustela_putorius_furo
ENSG00000116688	MFN2	97	65.629	ENSMLUG00000007603	MFN1	96	65.629	Myotis_lucifugus
ENSG00000116688	MFN2	100	95.773	ENSMLUG00000012698	MFN2	100	95.773	Myotis_lucifugus
ENSG00000116688	MFN2	97	64.946	ENSNGAG00000022452	Mfn1	99	64.993	Nannospalax_galili
ENSG00000116688	MFN2	100	96.169	ENSNGAG00000014552	Mfn2	100	96.169	Nannospalax_galili
ENSG00000116688	MFN2	96	63.784	ENSNBRG00000017365	mfn1b	97	63.784	Neolamprologus_brichardi
ENSG00000116688	MFN2	100	82.345	ENSNBRG00000021503	mfn2	100	82.345	Neolamprologus_brichardi
ENSG00000116688	MFN2	100	98.980	ENSNLEG00000009751	MFN2	100	93.395	Nomascus_leucogenys
ENSG00000116688	MFN2	89	60.324	ENSOPRG00000008074	MFN1	100	60.324	Ochotona_princeps
ENSG00000116688	MFN2	100	95.918	ENSOPRG00000006806	MFN2	100	94.055	Ochotona_princeps
ENSG00000116688	MFN2	100	96.939	ENSODEG00000015359	MFN2	100	96.565	Octodon_degus
ENSG00000116688	MFN2	97	65.536	ENSODEG00000002887	MFN1	99	65.536	Octodon_degus
ENSG00000116688	MFN2	96	63.919	ENSONIG00000001659	mfn1b	97	63.919	Oreochromis_niloticus
ENSG00000116688	MFN2	98	53.662	ENSONIG00000014073	-	99	54.410	Oreochromis_niloticus
ENSG00000116688	MFN2	92	67.239	ENSOANG00000004694	MFN1	98	67.239	Ornithorhynchus_anatinus
ENSG00000116688	MFN2	100	86.735	ENSOANG00000001700	MFN2	99	85.972	Ornithorhynchus_anatinus
ENSG00000116688	MFN2	100	96.939	ENSOCUG00000007972	MFN2	100	92.277	Oryctolagus_cuniculus
ENSG00000116688	MFN2	97	65.359	ENSOCUG00000000928	MFN1	98	65.359	Oryctolagus_cuniculus
ENSG00000116688	MFN2	80	34.615	ENSORLG00000007178	-	96	65.625	Oryzias_latipes
ENSG00000116688	MFN2	96	63.451	ENSORLG00000005858	mfn1b	97	63.451	Oryzias_latipes
ENSG00000116688	MFN2	100	81.506	ENSORLG00000025366	mfn2	100	81.506	Oryzias_latipes
ENSG00000116688	MFN2	96	63.772	ENSORLG00020021330	mfn1b	97	63.772	Oryzias_latipes_hni
ENSG00000116688	MFN2	80	37.179	ENSORLG00020016388	-	96	66.250	Oryzias_latipes_hni
ENSG00000116688	MFN2	100	81.374	ENSORLG00020001841	mfn2	100	81.374	Oryzias_latipes_hni
ENSG00000116688	MFN2	80	33.333	ENSORLG00015013590	-	96	65.312	Oryzias_latipes_hsok
ENSG00000116688	MFN2	96	64.043	ENSORLG00015018483	mfn1b	97	64.043	Oryzias_latipes_hsok
ENSG00000116688	MFN2	100	81.638	ENSORLG00015014785	mfn2	100	81.638	Oryzias_latipes_hsok
ENSG00000116688	MFN2	96	64.586	ENSOMEG00000014303	mfn1b	97	64.586	Oryzias_melastigma
ENSG00000116688	MFN2	76	37.838	ENSOMEG00000002180	-	89	66.149	Oryzias_melastigma
ENSG00000116688	MFN2	97	82.904	ENSOMEG00000023507	mfn2	100	82.904	Oryzias_melastigma
ENSG00000116688	MFN2	97	65.765	ENSOGAG00000000876	MFN1	99	65.765	Otolemur_garnettii
ENSG00000116688	MFN2	100	98.980	ENSOGAG00000005353	MFN2	100	97.490	Otolemur_garnettii
ENSG00000116688	MFN2	100	97.959	ENSOARG00000017763	MFN2	99	96.301	Ovis_aries
ENSG00000116688	MFN2	93	66.241	ENSOARG00000020701	MFN1	99	66.241	Ovis_aries
ENSG00000116688	MFN2	97	63.415	ENSPPAG00000043805	MFN1	99	63.735	Pan_paniscus
ENSG00000116688	MFN2	100	99.736	ENSPPAG00000028131	MFN2	100	99.736	Pan_paniscus
ENSG00000116688	MFN2	97	65.447	ENSPPRG00000001517	MFN1	99	65.765	Panthera_pardus
ENSG00000116688	MFN2	100	97.959	ENSPPRG00000007167	MFN2	100	97.094	Panthera_pardus
ENSG00000116688	MFN2	100	97.959	ENSPTIG00000020008	MFN2	100	97.094	Panthera_tigris_altaica
ENSG00000116688	MFN2	97	65.312	ENSPTIG00000008839	MFN1	99	65.629	Panthera_tigris_altaica
ENSG00000116688	MFN2	100	99.736	ENSPTRG00000000159	MFN2	100	99.736	Pan_troglodytes
ENSG00000116688	MFN2	100	99.211	ENSPANG00000024241	MFN2	100	99.211	Papio_anubis
ENSG00000116688	MFN2	97	64.141	ENSPANG00000018156	MFN1	96	64.141	Papio_anubis
ENSG00000116688	MFN2	97	64.586	ENSPKIG00000012717	mfn1b	99	64.586	Paramormyrops_kingsleyae
ENSG00000116688	MFN2	100	83.355	ENSPKIG00000013870	mfn2	100	83.355	Paramormyrops_kingsleyae
ENSG00000116688	MFN2	97	67.703	ENSPSIG00000013354	MFN1	98	67.703	Pelodiscus_sinensis
ENSG00000116688	MFN2	100	92.602	ENSPSIG00000010668	MFN2	100	92.602	Pelodiscus_sinensis
ENSG00000116688	MFN2	97	82.609	ENSPMGG00000017953	mfn2	99	82.609	Periophthalmus_magnuspinnatus
ENSG00000116688	MFN2	94	60.918	ENSPMGG00000012943	mfn1b	99	60.918	Periophthalmus_magnuspinnatus
ENSG00000116688	MFN2	97	65.900	ENSPEMG00000010348	Mfn1	99	65.900	Peromyscus_maniculatus_bairdii
ENSG00000116688	MFN2	100	96.939	ENSPEMG00000020166	Mfn2	100	96.433	Peromyscus_maniculatus_bairdii
ENSG00000116688	MFN2	97	66.622	ENSPCIG00000006771	MFN1	100	66.622	Phascolarctos_cinereus
ENSG00000116688	MFN2	100	91.413	ENSPCIG00000030255	MFN2	100	91.413	Phascolarctos_cinereus
ENSG00000116688	MFN2	96	63.859	ENSPFOG00000024230	mfn1b	97	63.859	Poecilia_formosa
ENSG00000116688	MFN2	93	52.624	ENSPFOG00000010519	-	99	52.624	Poecilia_formosa
ENSG00000116688	MFN2	100	79.815	ENSPFOG00000017078	mfn2	100	79.815	Poecilia_formosa
ENSG00000116688	MFN2	96	63.723	ENSPLAG00000003794	mfn1b	97	63.723	Poecilia_latipinna
ENSG00000116688	MFN2	100	73.737	ENSPLAG00000019259	mfn2	100	74.457	Poecilia_latipinna
ENSG00000116688	MFN2	96	63.995	ENSPMEG00000012626	mfn1b	97	63.995	Poecilia_mexicana
ENSG00000116688	MFN2	96	64.130	ENSPREG00000014938	mfn1b	95	73.438	Poecilia_reticulata
ENSG00000116688	MFN2	100	79.947	ENSPREG00000008521	mfn2	100	79.947	Poecilia_reticulata
ENSG00000116688	MFN2	97	63.279	ENSPPYG00000014318	MFN1	99	63.599	Pongo_abelii
ENSG00000116688	MFN2	97	62.313	ENSPCOG00000018204	MFN1	99	62.742	Propithecus_coquereli
ENSG00000116688	MFN2	100	98.980	ENSPCOG00000010547	MFN2	100	97.622	Propithecus_coquereli
ENSG00000116688	MFN2	97	66.035	ENSPVAG00000010800	MFN1	99	66.035	Pteropus_vampyrus
ENSG00000116688	MFN2	100	91.953	ENSPVAG00000001521	MFN2	100	91.953	Pteropus_vampyrus
ENSG00000116688	MFN2	96	63.587	ENSPNYG00000005303	mfn1b	97	63.587	Pundamilia_nyererei
ENSG00000116688	MFN2	97	82.927	ENSPNYG00000024126	mfn2	100	82.927	Pundamilia_nyererei
ENSG00000116688	MFN2	97	58.799	ENSPNAG00000001904	-	99	58.799	Pygocentrus_nattereri
ENSG00000116688	MFN2	100	84.280	ENSPNAG00000027163	mfn2	100	84.280	Pygocentrus_nattereri
ENSG00000116688	MFN2	96	66.035	ENSPNAG00000007467	mfn1b	99	66.035	Pygocentrus_nattereri
ENSG00000116688	MFN2	97	64.547	ENSRNOG00000011057	Mfn1	99	66.365	Rattus_norvegicus
ENSG00000116688	MFN2	100	95.918	ENSRNOG00000046424	Mfn2	100	95.509	Rattus_norvegicus
ENSG00000116688	MFN2	100	95.918	ENSRNOG00000046447	LOC100911485	100	94.619	Rattus_norvegicus
ENSG00000116688	MFN2	100	99.472	ENSRBIG00000044225	MFN2	100	99.472	Rhinopithecus_bieti
ENSG00000116688	MFN2	89	63.088	ENSRBIG00000035520	MFN1	94	63.088	Rhinopithecus_bieti
ENSG00000116688	MFN2	100	98.980	ENSRROG00000032834	MFN2	100	92.734	Rhinopithecus_roxellana
ENSG00000116688	MFN2	94	74.847	ENSRROG00000015013	MFN1	99	74.847	Rhinopithecus_roxellana
ENSG00000116688	MFN2	92	63.714	ENSSBOG00000034184	MFN1	96	63.714	Saimiri_boliviensis_boliviensis
ENSG00000116688	MFN2	100	99.339	ENSSBOG00000032019	MFN2	100	99.339	Saimiri_boliviensis_boliviensis
ENSG00000116688	MFN2	100	64.967	ENSSHAG00000016834	MFN1	100	64.967	Sarcophilus_harrisii
ENSG00000116688	MFN2	100	83.487	ENSSFOG00015010453	mfn2	100	83.487	Scleropages_formosus
ENSG00000116688	MFN2	97	64.682	ENSSFOG00015017937	mfn1b	99	64.682	Scleropages_formosus
ENSG00000116688	MFN2	97	60.354	ENSSFOG00015015604	MFN1	93	69.325	Scleropages_formosus
ENSG00000116688	MFN2	100	82.586	ENSSMAG00000003167	mfn2	100	82.586	Scophthalmus_maximus
ENSG00000116688	MFN2	96	63.686	ENSSMAG00000002898	mfn1b	97	63.686	Scophthalmus_maximus
ENSG00000116688	MFN2	97	65.034	ENSSDUG00000003272	mfn1b	99	65.034	Seriola_dumerili
ENSG00000116688	MFN2	96	56.772	ENSSDUG00000005964	-	99	56.772	Seriola_dumerili
ENSG00000116688	MFN2	97	81.004	ENSSDUG00000000877	mfn2	100	81.004	Seriola_dumerili
ENSG00000116688	MFN2	96	65.390	ENSSLDG00000017886	mfn1b	98	65.390	Seriola_lalandi_dorsalis
ENSG00000116688	MFN2	97	84.261	ENSSLDG00000024687	mfn2	100	84.261	Seriola_lalandi_dorsalis
ENSG00000116688	MFN2	80	39.744	ENSSLDG00000006788	-	98	68.323	Seriola_lalandi_dorsalis
ENSG00000116688	MFN2	71	72.593	ENSSARG00000013749	MFN1	76	72.593	Sorex_araneus
ENSG00000116688	MFN2	100	90.092	ENSSPUG00000012621	MFN2	100	90.092	Sphenodon_punctatus
ENSG00000116688	MFN2	96	65.452	ENSSPAG00000002472	mfn1b	97	65.452	Stegastes_partitus
ENSG00000116688	MFN2	100	83.245	ENSSPAG00000009269	mfn2	100	83.245	Stegastes_partitus
ENSG00000116688	MFN2	97	55.299	ENSSPAG00000008354	-	99	55.299	Stegastes_partitus
ENSG00000116688	MFN2	100	97.959	ENSSSCG00000003434	MFN2	100	96.301	Sus_scrofa
ENSG00000116688	MFN2	97	66.171	ENSSSCG00000039285	MFN1	99	66.171	Sus_scrofa
ENSG00000116688	MFN2	97	66.486	ENSTGUG00000010693	MFN1	100	66.486	Taeniopygia_guttata
ENSG00000116688	MFN2	100	91.678	ENSTGUG00000002433	-	100	91.678	Taeniopygia_guttata
ENSG00000116688	MFN2	96	63.179	ENSTRUG00000017563	mfn1b	99	62.892	Takifugu_rubripes
ENSG00000116688	MFN2	96	63.194	ENSTNIG00000015548	mfn1b	98	63.194	Tetraodon_nigroviridis
ENSG00000116688	MFN2	100	83.113	ENSTNIG00000004357	mfn2	100	83.113	Tetraodon_nigroviridis
ENSG00000116688	MFN2	74	100.000	ENSTBEG00000003798	MFN2	80	100.000	Tupaia_belangeri
ENSG00000116688	MFN2	92	66.237	ENSTBEG00000003479	MFN1	99	66.571	Tupaia_belangeri
ENSG00000116688	MFN2	100	96.939	ENSTTRG00000003510	MFN2	100	96.565	Tursiops_truncatus
ENSG00000116688	MFN2	92	63.000	ENSTTRG00000001572	MFN1	99	63.000	Tursiops_truncatus
ENSG00000116688	MFN2	100	97.959	ENSUAMG00000010390	MFN2	100	97.094	Ursus_americanus
ENSG00000116688	MFN2	97	65.900	ENSUAMG00000007614	MFN1	99	65.900	Ursus_americanus
ENSG00000116688	MFN2	97	65.900	ENSUMAG00000007570	MFN1	99	65.900	Ursus_maritimus
ENSG00000116688	MFN2	100	97.959	ENSUMAG00000022141	MFN2	100	96.962	Ursus_maritimus
ENSG00000116688	MFN2	67	99.091	ENSVPAG00000002783	-	72	99.091	Vicugna_pacos
ENSG00000116688	MFN2	97	66.035	ENSVVUG00000004780	MFN1	99	66.035	Vulpes_vulpes
ENSG00000116688	MFN2	100	97.959	ENSVVUG00000028576	MFN2	100	97.358	Vulpes_vulpes
ENSG00000116688	MFN2	99	80.688	ENSXETG00000013049	mfn2	100	80.688	Xenopus_tropicalis
ENSG00000116688	MFN2	97	62.195	ENSXETG00000007258	mfn1	99	62.195	Xenopus_tropicalis
ENSG00000116688	MFN2	97	80.597	ENSXCOG00000002115	mfn2	100	80.597	Xiphophorus_couchianus
ENSG00000116688	MFN2	87	64.939	ENSXCOG00000002951	mfn1b	99	64.939	Xiphophorus_couchianus
ENSG00000116688	MFN2	98	80.754	ENSXMAG00000004637	mfn2	98	80.754	Xiphophorus_maculatus
ENSG00000116688	MFN2	80	39.744	ENSXMAG00000021517	-	93	65.528	Xiphophorus_maculatus
ENSG00000116688	MFN2	96	63.636	ENSXMAG00000018170	mfn1b	97	63.636	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0001825	blastocyst formation	-	IEA	Process
GO:0003924	GTPase activity	21873635.	IBA	Function
GO:0005515	protein binding	17121834.23620051.24282027.27059175.	IPI	Function
GO:0005525	GTP binding	-	IEA	Function
GO:0005739	mitochondrion	11181170.20871098.	IDA	Component
GO:0005741	mitochondrial outer membrane	-	TAS	Component
GO:0005829	cytosol	-	ISS	Component
GO:0006626	protein targeting to mitochondrion	11181170.	IDA	Process
GO:0006915	apoptotic process	-	IEA	Process
GO:0006986	response to unfolded protein	-	IEA	Process
GO:0007006	mitochondrial membrane organization	11181170.	IDA	Process
GO:0007050	cell cycle arrest	-	ISS	Process
GO:0007596	blood coagulation	-	TAS	Process
GO:0008053	mitochondrial fusion	21873635.	IBA	Process
GO:0008053	mitochondrial fusion	23921378.	IMP	Process
GO:0008053	mitochondrial fusion	-	ISS	Process
GO:0008053	mitochondrial fusion	11181170.	NAS	Process
GO:0015630	microtubule cytoskeleton	-	IEA	Component
GO:0016021	integral component of membrane	-	IEA	Component
GO:0016236	macroautophagy	-	TAS	Process
GO:0031306	intrinsic component of mitochondrial outer membrane	21873635.	IBA	Component
GO:0031306	intrinsic component of mitochondrial outer membrane	-	ISS	Component
GO:0031625	ubiquitin protein ligase binding	16936636.	IPI	Function
GO:0034497	protein localization to phagophore assembly site	23455425.	IDA	Process
GO:0046580	negative regulation of Ras protein signal transduction	15322553.	IDA	Process
GO:0048593	camera-type eye morphogenesis	-	IEA	Process
GO:0048662	negative regulation of smooth muscle cell proliferation	-	ISS	Process
GO:0051646	mitochondrion localization	21873635.	IBA	Process
GO:0051646	mitochondrion localization	11181170.	IDA	Process
GO:0061734	parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization	-	ISS	Process
GO:0120162	positive regulation of cold-induced thermogenesis	28539390.	ISS	Process
GO:1904707	positive regulation of vascular smooth muscle cell proliferation	27640178.	IMP	Process
GO:1905461	positive regulation of vascular associated smooth muscle cell apoptotic process	27640178.	IMP	Process

EuRBPDB

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Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBDs

Expression

Transcripts

Gene Model

Pathway

Phenotype

GWAS

PPI

Ortholog

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.