EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr1	109621097	Silent	novel	R28R	0.37
BLCA	chr1	109628250	Silent	novel	L470L	0.52
BLCA	chr1	109630337	Silent	rs368213563	P750P	0.16
BLCA	chr1	109630287	Missense_Mutation	novel	P734A	0.05
BLCA	chr1	109630288	Missense_Mutation	rs761542502	P734L	0.05
BLCA	chr1	109629337	Missense_Mutation	novel	F624C	0.51
BLCA	chr1	109621123	In_Frame_Del	novel	P38_R42del	0.21
BLCA	chr1	109625775	Missense_Mutation	novel	Q166H	0.15
BLCA	chr1	109629453	Missense_Mutation	novel	T663S	0.04
BLCA	chr1	109626730	Missense_Mutation	novel	P233Q	0.43
BLCA	chr1	109629823	Silent	rs772396309	L684L	0.3
BRCA	chr1	109620076	5'Flank	novel		0.11
BRCA	chr1	109628492	Silent	NA	I522I	0.17
BRCA	chr1	109625674	Missense_Mutation	rs781032788	R133C	0.4
BRCA	chr1	109626396	Missense_Mutation	novel	R221Q	0.12
BRCA	chr1	109628168	Missense_Mutation	novel	E443G	0.11
BRCA	chr1	109625718	In_Frame_Del	novel	E149_P152del	0.67
CESC	chr1	109625700	Silent	novel	R141R	0.37
CESC	chr1	109626832	Missense_Mutation	rs764075553	R267H	0.3
CESC	chr1	109631816	3'UTR	novel		0.45
CESC	chr1	109621202	Silent	novel	G63G	0.22
CESC	chr1	109627793	Missense_Mutation	rs776868175	R378W	0.47
CESC	chr1	109628276	Missense_Mutation	NA	A479V	0.23
CESC	chr1	109630683	Missense_Mutation	NA	E774Q	0.3
CESC	chr1	109629823	Silent	novel	L684L	0.23
COAD	chr1	109629421	Missense_Mutation	novel	D652A	0.14
COAD	chr1	109621052	Silent	novel	S13S	0.24
COAD	chr1	109626346	Frame_Shift_Del	NA	*G205Vfs158**	0.18
COAD	chr1	109628217	Silent	NA	V459V	0.51
COAD	chr1	109629396	Silent	novel	L644L	0.27
COAD	chr1	109631231	3'UTR	novel		0.28
COAD	chr1	109625308	Missense_Mutation	rs202115880	R87W	0.26
COAD	chr1	109625623	Intron	rs771719443		0.41
COAD	chr1	109630351	Missense_Mutation	NA	R755H	0.36
COAD	chr1	109625616	Intron	rs755176761		0.4
COAD	chr1	109629217	Silent	novel	L614L	0.34
COAD	chr1	109629898	Silent	rs369921795	H709H	0.1
COAD	chr1	109630709	Silent	rs367822022	I782I	0.34
COAD	chr1	109631215	3'UTR	rs186513447		0.09
COAD	chr1	109627188	Frame_Shift_Del	NA	*P300Lfs63**	0.43
COAD	chr1	109628150	Missense_Mutation	NA	A437E	0.43
COAD	chr1	109630246	Missense_Mutation	NA	Q720R	0.38
COAD	chr1	109629912	Missense_Mutation	NA	R714H	0.26
COAD	chr1	109628261	Missense_Mutation	NA	T474M	0.28
COAD	chr1	109627188	Frame_Shift_Del	NA	*P300Lfs63**	0.14
COAD	chr1	109627873	Silent	novel	V404V	0.1
COAD	chr1	109625654	Splice_Region	rs770280481		0.26
COAD	chr1	109628204	Missense_Mutation	rs751131036	T455M	0.31
COAD	chr1	109626220	Silent	rs763135190	S192S	0.42
COAD	chr1	109628748	Missense_Mutation	rs774595273	V559I	0.61
COAD	chr1	109621082	Frame_Shift_Del	novel	*A25Rfs162**	0.31
COAD	chr1	109625384	Missense_Mutation	novel	P112L	0.06
COAD	chr1	109630271	Silent	NA	I728I	0.36
COAD	chr1	109625752	Missense_Mutation	NA	R159W	0.21
COAD	chr1	109627791	Missense_Mutation	rs747822677	R377H	0.23
COAD	chr1	109628709	Missense_Mutation	NA	R546C	0.24
COAD	chr1	109628778	Missense_Mutation	NA	R569C	0.21
DLBC	chr1	109628406	Missense_Mutation	novel	Y494N	0.43
DLBC	chr1	109626403	Silent	novel	T223T	0.31
ESCA	chr1	109620820	5'UTR	novel		0.24
ESCA	chr1	109621195	Missense_Mutation	novel	G61D	0.43
ESCA	chr1	109629889	Frame_Shift_Del	novel	*N706Kfs71**	0.24
GBM	chr1	109620219	5'Flank	novel		0.1
GBM	chr1	109629486	Missense_Mutation	rs756745194	R674C	0.03
GBM	chr1	109621039	Missense_Mutation	novel	F9C	0.46
GBM	chr1	109620165	5'Flank	novel		0.19
HNSC	chr1	109620205	5'Flank	novel		0.43
HNSC	chr1	109627793	Silent	novel	R378R	0.26
HNSC	chr1	109625709	Silent	rs139217835	P144P	0.31
KICH	chr1	109626158	Splice_Site	novel	X172_splice	0.48
KIRC	chr1	109627443	Missense_Mutation	novel	E346V	0.45
KIRP	chr1	109628194	Missense_Mutation	NA	R452G	0.48
KIRP	chr1	109625674	Missense_Mutation	rs781032788	R133C	0.06
LGG	chr1	109628209	Missense_Mutation	rs373128067	R457W	0.37
LGG	chr1	109626176	Missense_Mutation	NA	L178V	0.2
LIHC	chr1	109630970	Missense_Mutation	novel	Y820N	0.25
LIHC	chr1	109628426	Silent	rs772949801	S500S	0.11
LIHC	chr1	109626183	Missense_Mutation	NA	R180Q	0.04
LUAD	chr1	109625678	Nonsense_Mutation	NA	S134*	0.11
LUAD	chr1	109629344	Silent	rs116415979	S626S	0.18
LUAD	chr1	109625670	Missense_Mutation	NA	F131L	0.17
LUAD	chr1	109626338	Nonsense_Mutation	NA	E202*	0.13
LUAD	chr1	109621048	Missense_Mutation	NA	R12Q	0.24
LUAD	chr1	109630271	Silent	NA	I728I	0.34
LUAD	chr1	109621024	Missense_Mutation	novel	R4L	0.46
LUAD	chr1	109625420	Missense_Mutation	NA	K124M	0.25
LUAD	chr1	109628135	Missense_Mutation	novel	R432L	0.25
LUSC	chr1	109625364	Silent	novel	A105A	0.18
LUSC	chr1	109625686	Missense_Mutation	novel	E137K	0.17
LUSC	chr1	109626340	Missense_Mutation	novel	E202D	0.23
LUSC	chr1	109630327	Missense_Mutation	novel	N747S	0.31
LUSC	chr1	109627481	Missense_Mutation	rs553822688	V359I	0.17
OV	chr1	109626335	Missense_Mutation	NA	G201C	0.65
OV	chr1	109620218	5'Flank	novel		0.07
OV	chr1	109626343	Silent	novel	G203G	0.11
OV	chr1	109628125	Missense_Mutation	NA	H429Y	0.41
PAAD	chr1	109630337	Silent	rs368213563	P750P	0.19
PRAD	chr1	109629140	Missense_Mutation	NA	N589D	0.36
READ	chr1	109628714	Silent	rs777419165	S547S	0.39
SARC	chr1	109631002	Silent	novel	I830I	0.31
SARC	chr1	109620877	5'UTR	novel		0.15
SKCM	chr1	109621016	Translation_Start_Site	NA	M1?	0.26
SKCM	chr1	109627897	Silent	novel	I412I	0.36
SKCM	chr1	109621104	Silent	NA	L31L	0.26
SKCM	chr1	109625733	Silent	NA	P152P	0.2
SKCM	chr1	109630332	Silent	novel	L749L	0.55
SKCM	chr1	109630367	Silent	novel	S760S	0.41
SKCM	chr1	109625359	Missense_Mutation	novel	P104S	0.46
SKCM	chr1	109625360	Missense_Mutation	NA	P104L	0.48
SKCM	chr1	109627180	Missense_Mutation	NA	P296S	0.41
SKCM	chr1	109629394	Missense_Mutation	novel	P643L	0.24
SKCM	chr1	109621037	Silent	NA	L8L	0.17
SKCM	chr1	109628105	Missense_Mutation	NA	S422L	0.34
SKCM	chr1	109628425	Missense_Mutation	novel	S500F	0.11
SKCM	chr1	109628426	Silent	rs772949801	S500S	0.11
SKCM	chr1	109620237	5'Flank	rs376645140		0.7
SKCM	chr1	109621037	Silent	NA	L8L	0.32
SKCM	chr1	109628175	Silent	rs562274293	I445I	0.17
SKCM	chr1	109625382	Silent	NA	F111F	0.22
SKCM	chr1	109625343	Silent	novel	A98A	0.36
SKCM	chr1	109629223	Silent	novel	L616L	0.25
SKCM	chr1	109625698	Missense_Mutation	NA	R141C	0.13
SKCM	chr1	109627453	Silent	NA	Y349Y	0.2
SKCM	chr1	109626199	Silent	NA	F185F	0.31
SKCM	chr1	109630975	Silent	novel	T821T	0.21
SKCM	chr1	109626400	Silent	NA	V222V	0.18
SKCM	chr1	109621023	Missense_Mutation	NA	R4C	0.87
STAD	chr1	109631028	Missense_Mutation	NA	R839H	0.22
STAD	chr1	109628706	Missense_Mutation	NA	G545R	0.24
STAD	chr1	109625622	Intron	novel		0.24
STAD	chr1	109631024	Missense_Mutation	NA	I838V	0.09
STAD	chr1	109627860	Missense_Mutation	novel	A400V	0.22
STAD	chr1	109629345	Missense_Mutation	NA	V627M	0.1
STAD	chr1	109628210	Missense_Mutation	rs754312171	R457Q	0.23
STAD	chr1	109625395	Missense_Mutation	rs751988000	R116C	0.17
STAD	chr1	109625363	Frame_Shift_Del	novel	*C107Afs80**	0.22
STAD	chr1	109626182	Missense_Mutation	rs765794204	R180W	0.31
STAD	chr1	109627188	Frame_Shift_Del	NA	*P300Lfs63**	0.39
STAD	chr1	109628739	Missense_Mutation	rs116156816	R556C	0.22
STAD	chr1	109625395	Missense_Mutation	rs751988000	R116C	0.28
STAD	chr1	109626768	Missense_Mutation	novel	R246W	0.06
STAD	chr1	109629442	Missense_Mutation	novel	Y659C	0.11
STAD	chr1	109629912	Missense_Mutation	NA	R714H	0.23
STAD	chr1	109629406	Missense_Mutation	rs376516473	A647V	0.28
THCA	chr1	109629212	Nonsense_Mutation	novel	E613*	0.2
THCA	chr1	109628085	Splice_Region	rs780496887	V415V	0.07
THCA	chr1	109628141	Missense_Mutation	NA	I434T	0.17
UCEC	chr1	109625614	Intron	novel		0.21
UCEC	chr1	109625358	Silent	novel	G103G	0.28
UCEC	chr1	109625396	Missense_Mutation	rs749976113	R116H	0.34
UCEC	chr1	109628429	Silent	novel	V501V	0.11
UCEC	chr1	109625394	Silent	novel	L115L	0.52
UCEC	chr1	109631077	Silent	rs373514741	T855T	0.39
UCEC	chr1	109631900	3'UTR	novel		0.48
UCEC	chr1	109625709	Silent	rs139217835	P144P	0.2
UCEC	chr1	109628651	Missense_Mutation	NA	M526I	0.2
UCEC	chr1	109631325	3'UTR	novel		0.18
UCEC	chr1	109626354	Missense_Mutation	NA	R207Q	0.52
UCEC	chr1	109627508	Missense_Mutation	NA	N368D	0.44
UCEC	chr1	109630778	Silent	novel	S805S	0.33
UCEC	chr1	109627312	Missense_Mutation	NA	E340K	0.25
UCEC	chr1	109631205	3'UTR	novel		0.08
UCEC	chr1	109627852	Silent	novel	E397E	0.29
UCEC	chr1	109632007	3'UTR	rs761631843		0.51
UCEC	chr1	109620066	5'Flank	novel		0.38
UCEC	chr1	109626724	Splice_Site	novel	X232_splice	0.27
UCEC	chr1	109631786	3'UTR	novel		0.27
UCEC	chr1	109628713	Missense_Mutation	rs772196474	S547L	0.38
UCEC	chr1	109629911	Missense_Mutation	NA	R714C	0.4
UCEC	chr1	109630349	Silent	novel	S754S	0.38
UCEC	chr1	109628759	Silent	rs201301109	R562R	0.33
UCEC	chr1	109630278	Missense_Mutation	NA	A731T	0.43
UCEC	chr1	109628709	Missense_Mutation	NA	R546C	0.27
UCEC	chr1	109627265	Missense_Mutation	rs749468757	R324H	0.33
UCEC	chr1	109631044	Silent	novel	Y844Y	0.38
UCEC	chr1	109628396	Missense_Mutation	novel	F490L	0.67
UCEC	chr1	109628276	Missense_Mutation	NA	A479V	0.08
UCEC	chr1	109626352	Missense_Mutation	NA	D206E	0.35
UCEC	chr1	109629486	Missense_Mutation	rs756745194	R674C	0.1
UCEC	chr1	109627188	Frame_Shift_Del	NA	*P300Lfs63**	0.33
UCEC	chr1	109629324	Splice_Region	novel		0.53
UCEC	chr1	109620251	5'Flank	novel		0.3
UCEC	chr1	109625319	Frame_Shift_Del	novel	*A92Pfs95**	0.32
UCEC	chr1	109625392	Silent	novel	L115L	0.5
UCEC	chr1	109626893	Silent	rs778185309	P287P	0.37
UCEC	chr1	109631043	Missense_Mutation	NA	Y844C	0.32
UCEC	chr1	109627859	Missense_Mutation	NA	A400T	0.38
UCEC	chr1	109625355	Silent	rs775613960	P102P	0.3
UCEC	chr1	109620120	5'Flank	rs554931328		0.55
UCEC	chr1	109620761	5'UTR	novel		0.07
UCEC	chr1	109631860	3'UTR	novel		0.45
UCEC	chr1	109628212	Nonsense_Mutation	novel	E458*	0.39
UCEC	chr1	109629167	Missense_Mutation	novel	F598L	0.15
UCEC	chr1	109630337	Silent	rs368213563	P750P	0.2
UCEC	chr1	109626874	Missense_Mutation	novel	R281Q	0.49
UCEC	chr1	109629117	Missense_Mutation	novel	Y581C	0.35
UCEC	chr1	109620117	5'Flank	novel		0.35
UCEC	chr1	109620978	5'UTR	novel		0.14
UCEC	chr1	109627177	Frame_Shift_Ins	novel	*V297Gfs12**	0.41
UCEC	chr1	109628775	Missense_Mutation	novel	V568M	0.11
UCEC	chr1	109631029	Silent	rs768281624	R839R	0.35
UCEC	chr1	109631121	Missense_Mutation	novel	A870V	0.4
UCEC	chr1	109632007	3'UTR	rs761631843		0.32
UCS	chr1	109621018	Missense_Mutation	novel	R2I	0.5

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
BRCA	DEL	0.2435	5.7821e-10
CESC	DEL	0.0949	0.01281
COAD	DEL	0.2217	0.00038973
DLBC	DEL	0.1042	0.0017831
LUAD	DEL	0.2364	2.5961e-13
MESO	DEL	0.3793	5.9874e-12
READ	DEL	0.2788	0.013822
SKCM	DEL	0.1798	9.7877e-07
STAD	DEL	0.1633	0.0040659
TGCT	AMP	0.1867	0.088103

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.0001	Kaplan-Meier Survival Analysis
STAD	0.035	Kaplan-Meier Survival Analysis
SARC	0.00034	Kaplan-Meier Survival Analysis
PAAD	0.004	Kaplan-Meier Survival Analysis
READ	0.028	Kaplan-Meier Survival Analysis
UCEC	0.001	Kaplan-Meier Survival Analysis
LIHC	0.011	Kaplan-Meier Survival Analysis
THCA	0.027	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000116337 (Gene tree)
Gene ID: 271
Gene Symbol: AMPD2
Alias: SPG63
Full Name: adenosine monophosphate deaminase 2
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 15,952 bases
Position: chr1:109,616,104-109,632,055
Accession: 469
RBP type: non-canonical RBP
Summary: The protein encoded by this gene is important in purine metabolism by converting AMP to IMP. The encoded protein, which acts as a homotetramer, is one of three AMP deaminases found in mammals. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000528958	AMPD2-220	714	-	-	- (aa)	-	-
ENST00000527846	AMPD2-216	585	-	ENSP00000431904	195 (aa)	-	H0YCL9
ENST00000529299	AMPD2-221	583	-	-	- (aa)	-	-
ENST00000467071	AMPD2-207	556	-	-	- (aa)	-	-
ENST00000531203	AMPD2-222	575	-	ENSP00000431975	87 (aa)	-	E9PIJ1
ENST00000369840	AMPD2-204	3130	-	ENSP00000358855	861 (aa)	-	H0Y360
ENST00000469039	AMPD2-208	513	-	ENSP00000436303	1 (aa)	-	UPI0000055EF8
ENST00000476688	AMPD2-210	1111	-	ENSP00000437025	231 (aa)	-	H0YF16
ENST00000526301	AMPD2-215	2354	-	-	- (aa)	-	-
ENST00000534144	AMPD2-226	544	-	-	- (aa)	-	-
ENST00000459643	AMPD2-206	550	-	-	- (aa)	-	-
ENST00000531734	AMPD2-223	572	-	ENSP00000433739	103 (aa)	-	E9PJF6
ENST00000474459	AMPD2-209	814	-	ENSP00000432344	1 (aa)	-	UPI0000055EF8
ENST00000532851	AMPD2-224	865	-	-	- (aa)	-	-
ENST00000393688	AMPD2-205	3217	-	ENSP00000377292	760 (aa)	-	Q01433
ENST00000528270	AMPD2-217	588	-	ENSP00000434891	83 (aa)	-	H0YE32
ENST00000486282	AMPD2-212	582	-	-	- (aa)	-	-
ENST00000256578	AMPD2-201	3899	-	ENSP00000256578	879 (aa)	-	Q01433
ENST00000528667	AMPD2-219	3134	-	ENSP00000436541	879 (aa)	-	Q01433
ENST00000524975	AMPD2-213	678	-	-	- (aa)	-	-
ENST00000528454	AMPD2-218	2728	-	ENSP00000437164	761 (aa)	-	Q01433
ENST00000533132	AMPD2-225	717	-	-	- (aa)	-	-
ENST00000525415	AMPD2-214	580	-	-	- (aa)	-	-
ENST00000479919	AMPD2-211	690	-	-	- (aa)	-	-
ENST00000358729	AMPD2-203	2838	XM_024446431	ENSP00000351573	804 (aa)	XP_024302199	Q01433
ENST00000342115	AMPD2-202	3728	-	ENSP00000345498	798 (aa)	-	Q01433

Gene Model

Click here to download ENSG00000116337's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa00230	Purine metabolism	KEGG
hsa01100	Metabolic pathways	KEGG

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000116337's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000116337	AMPD2	89	53.086	YML035C	AMD1	76	52.648	Saccharomyces_cerevisiae

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003876	AMP deaminase activity	21873635.	IBA	Function
GO:0003876	AMP deaminase activity	23911318.	IGI	Function
GO:0003876	AMP deaminase activity	8764830.	NAS	Function
GO:0005515	protein binding	21044950.25416956.	IPI	Function
GO:0005829	cytosol	21873635.	IBA	Component
GO:0005829	cytosol	-	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0006188	IMP biosynthetic process	21873635.	IBA	Process
GO:0006188	IMP biosynthetic process	23911318.	IGI	Process
GO:0032264	IMP salvage	-	IEA	Process
GO:0043101	purine-containing compound salvage	-	TAS	Process
GO:0046033	AMP metabolic process	21873635.	IBA	Process
GO:0046872	metal ion binding	-	IEA	Function
GO:0052652	cyclic purine nucleotide metabolic process	23911318.	IMP	Process
GO:0097009	energy homeostasis	23911318.	IGI	Process

EuRBPDB

Note: to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

PPI

Orthologs

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.