EuRBPDB

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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
22526154DJ-1, a novel biomarker and a selected target gene for overcoming chemoresistance in pancreatic cancer.J Cancer Res Clin Oncol2012 SepChen Ydoi: 10.1007/s00432-012-1205-3
29147911DJ-1 as a Therapeutic Target Against Cancer.Adv Exp Med Biol2017Cao Jdoi: 10.1007/978-981-10-6583-5_13.
20150646Prognostic significance of nuclear DJ-1 expression in astrocytoma.Anticancer Res2010 JanMiyajima Y-
22404125High levels of DJ-1 protein in nipple fluid of patients with breast cancer.Cancer Sci2012 JunOda Mdoi: 10.1111/j.1349-7006.2012.02267.x
22968650Macrophage migration inhibitory factor and DJ-1 in gastric cancer: differences between high-incidence and low-incidence areas.Br J Cancer2012 Oct 23Shimwell NJdoi: 10.1038/bjc.2012.405
26334622Diagnostic and prognostic value of serum thioredoxin and DJ-1 in non-small cell lung carcinoma patients.Tumour Biol2016 FebFan Jdoi: 10.1007/s13277-015-3994-x
28653888DJ-1 as a potential biomarker for the early diagnosis in lung cancer patients.Tumour Biol2017 JunHan Bdoi: 10.1177/1010428317714625.
28580701Identification of DJ-1 as a contributor to multidrug resistance in human small-cell lung cancer using proteomic analysis.Int J Exp Pathol2017 AprGao Hdoi: 10.1111/iep.12221
26245297Status of the Parkinson's disease gene family expression in non-small-cell lung cancer.World J Surg Oncol2015 Aug 7Liu QXdoi: 10.1186/s12957-015-0646-y.
21943684Nuclear factor erythroid-derived 2-like 2 (Nrf2) and DJ1 are prognostic factors in lung cancer.Hum Pathol2012 AprMerikallio Hdoi: 10.1016/j.humpath.2011.05.024
23592371DJ-1 protein expression as a predictor of pathological complete remission after neoadjuvant chemotherapy in breast cancer patients.Breast Cancer Res Treat2013 MayKawate Tdoi: 10.1007/s10549-013-2523-0
17015834DJ-1, a cancer- and Parkinson's disease-associated protein, stabilizes the antioxidant transcriptional master regulator Nrf2.Proc Natl Acad Sci U S A2006 Oct 10Clements CM-
26125099Pleural effusion levels of DJ-1 are increased in elderly lung cancer patients with malignant pleural effusions.Redox Rep2015Vavougios Gdoi: 10.1179/1351000215Y.0000000023
24614826DJ-1 in endometrial cancer: a possible biomarker to improve differential diagnosis between subtypes.Int J Gynecol Cancer2014 MayMorelli Mdoi: 10.1097/IGC.0000000000000102.
24207095DJ-1 and androgen receptor immunohistochemical expression in prostatic carcinoma: a possible role in carcinogenesis.J Egypt Natl Canc Inst2013 DecOsman WMdoi: 10.1016/j.jnci.2013.08.001
24504364DJ-1 upregulates breast cancer cell invasion by repressing KLF17 expression.Br J Cancer2014 Mar 4Ismail IAdoi: 10.1038/bjc.2014.40
24681255DJ-1 mediates the resistance of cancer cells to dihydroartemisinin through reactive oxygen species removal.Free Radic Biol Med2014 JunZhu Hdoi: 10.1016/j.freeradbiomed.2014.03.026
21670963DJ-1 may contribute to metastasis of non-small cell lung cancer.Mol Biol Rep2012 MarBai Jdoi: 10.1007/s11033-011-1024-7
15766664DJ-1, a novel regulator of the tumor suppressor PTEN.Cancer Cell2005 MarKim RH-
26261582Role of DJ-1 siRNA in reverse sensitivity of breast cancer cells to chemotherapy and its possible mechanism.Int J Clin Exp Pathol2015 Jun 1Zhang GQ-
23727824Expression of DJ-1 in endometrial cancer: close correlation with clinicopathological features and apoptosis.Int J Gynecol Cancer2013 JulShu Kdoi: 10.1097/IGC.0b013e3182959182.
25867058High levels of DJ-1 protein and isoelectric point 6.3 isoform in sera of breast cancer patients.Cancer Sci2015 JulKawate Tdoi: 10.1111/cas.12673
25892179DJ-1-induced phosphatase and tensin homologue downregulation is associated with proliferative and invasive activity of laryngeal cancer cells.Mol Med Rep2015 AugZhu XLdoi: 10.3892/mmr.2015.3617
27664330Exosomal proteins as prostate cancer biomarkers in urine: From mass spectrometry discovery to immunoassay-based validation.Eur J Pharm Sci2017 Feb 15Wang Ldoi: 10.1016/j.ejps.2016.09.023
28618925DJ-1 is a reliable serum biomarker for discriminating high-risk endometrial cancer.Tumour Biol2017 JunDi Cello Adoi: 10.1177/1010428317705746.
27611333Regulation of Reactive Oxygen Species and the Antioxidant Protein DJ-1 in Mastocytosis.PLoS One2016 Sep 9Kim DKdoi: 10.1371/journal.pone.0162831
27582551Novel association of DJ-1 with HER3 potentiates HER3 activation and signaling in cancer.Oncotarget2016 Oct 4Zhang Sdoi: 10.18632/oncotarget.11613.
29147902Expression of DJ-1 in Cancer Cells: Its Correlation with Clinical Significance.Adv Exp Med Biol2017Kawate Tdoi: 10.1007/978-981-10-6583-5_4.
28374920The clinical significance of DJ-1 and HE4 in patients with endometrial cancer.J Clin Lab Anal2018 JanBenati Mdoi: 10.1002/jcla.22223
28963699NRG-1 Stimulates Serum DJ-1 Increase in Breast Cancers.Pathol Oncol Res2019 JanWang Ydoi: 10.1007/s12253-017-0326-z
30536064DJ-1 Alters Epirubicin-induced Apoptosis via Modulating Epirubicinactivated Autophagy in Human Gastric Cancer Cells.Curr Med Sci2018 DecPan XKdoi: 10.1007/s11596-018-1978-y
30894531Reversible histone glycation is associated with disease-related changes in chromatin architecture.Nat Commun2019 Mar 20Zheng Qdoi: 10.1038/s41467-019-09192-z.

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
BLCAchr17969402Missense_MutationnovelE84K0.45
BLCAchr17962831Missense_MutationnovelE16K0.16
BLCAchr17965365SilentnovelV44V0.24
BRCAchr17977658Missense_MutationnovelT110N0.28
BRCAchr17971179Intronnovel0.57
CESCchr179850923'UTRrs3750818480.43
CESCchr179850803'UTRnovel0.27
CESCchr17984957Missense_MutationnovelP158H0.19
CESCchr17970917SilentNAL92L0.14
CESCchr17971104Intronnovel0.38
COADchr179850673'UTRnovel0.36
COADchr17965416Frame_Shift_DelNAE64Rfs*250.24
COADchr17965416Frame_Shift_DelNAE64Rfs*250.37
COADchr17965376Missense_Mutationrs145727915R48H0.28
COADchr17971141Intronnovel0.63
COADchr17965415Frame_Shift_Insrs759703272E64Rfs*50.15
GBMchr179851223'UTRnovel0.06
GBMchr17977740Splice_SitenovelX137_splice0.29
GBMchr17984997SilentnovelA171A0.11
HNSCchr17962843Missense_MutationnovelV20I0.77
HNSCchr17965404SilentnovelS57S0.1
LGGchr17977707SilentnovelH126H0.06
PRADchr17965393Missense_MutationNAP54A0.25
PRADchr17984867Intronnovel0.08
SKCMchr17965374SilentNAS47S0.37
SKCMchr179627745'UTRnovel0.32
SKCMchr179851583'UTRnovel0.86
STADchr17965335Silentrs374236728T34T0.18
THCAchr179850593'UTRnovel0.06
THCAchr179850613'UTRnovel0.04
THCAchr179850883'UTRnovel0.13
THCAchr179850903'UTRnovel0.05
UCECchr17962808Missense_MutationnovelV8A0.36
UCECchr17965416Frame_Shift_DelNAE64Rfs*250.28
UCECchr17970895Missense_MutationnovelS85Y0.38
UCECchr17984979Silentrs768890106A165A0.28
UCECchr17971064Intronnovel0.3
UCECchr17970933Missense_Mutationrs182164240R98W0.25
UCECchr17984978Missense_Mutationrs371514726A165V0.3
UCECchr17962841Missense_Mutationrs758016497T19M0.19
UCECchr17971085Intronnovel0.04
UCECchr17977684Missense_MutationnovelF119V0.34
UCECchr179850853'UTRnovel0.39
UCECchr17965338SilentnovelV35V0.39
UCECchr17971085Intronnovel0.08
UCECchr17971085Intronnovel0.07
UCECchr17984917Missense_Mutationrs768782230R145C0.82
UVMchr17971029Intronnovel0.24

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
CESCDEL0.11530.00029523
CHOLDEL0.77783.3987e-23
DLBCDEL0.14580.011841
GBMDEL0.21492.9271e-58
HNSCDEL0.13987.0766e-07
KIRCDEL0.14582.3538e-09
KIRPDEL0.17711.462e-09
LUADDEL0.14340.0024765
LUSCDEL0.35332.5882e-07
MESODEL0.35632.434e-07
READDEL0.38182.1758e-10
TGCTDEL0.18670.00046313
UCSDEL0.30360.0051125

Survival Analysis
CancerP-value Q-value
KIRC0.00013

Kaplan-Meier Survival Analysis

MESO0.0077

Kaplan-Meier Survival Analysis

ACC0.0061

Kaplan-Meier Survival Analysis

ESCA0.031

Kaplan-Meier Survival Analysis

KIRP0.0047

Kaplan-Meier Survival Analysis

PCPG0.03

Kaplan-Meier Survival Analysis

LAML0.00016

Kaplan-Meier Survival Analysis

KICH0.021

Kaplan-Meier Survival Analysis

UVM0.0015

Kaplan-Meier Survival Analysis

Drugs

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Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBPome
  • Literatures
  • Expression
  • Transcripts
  • Gene Model
  • Pathways
  • Phenotypes
  • GWAS
  • PPI
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000116288 (Gene tree)
Gene ID
11315
Gene Symbol
PARK7
Alias
DJ-1|DJ1|GATD2
Full Name
Parkinsonism associated deglycase
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Plus strand
Length
31,215 bases
Position
chr1:7,954,291-7,985,505
Accession
16369
RBP type
non-canonical RBP
Summary
The product of this gene belongs to the peptidase C56 family of proteins. It acts as a positive regulator of androgen receptor-dependent transcription. It may also function as a redox-sensitive chaperone, as a sensor for oxidative stress, and it apparently protects neurons against oxidative stress and cell death. Defects in this gene are the cause of autosomal recessive early-onset Parkinson disease 7. Two transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008]
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & HEK2932019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
29431736Capturing the interactome of newly transcribed RNAPolyT-RICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
29431736Capturing the interactome of newly transcribed RNARICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & MCF10A2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
27453046Comprehensive Identification of RNA-Binding Domains in Human CellsRIC & Hela2016 Aug 18Castello ADOI: 10.1016/j.molcel.2016.06.029

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
11223268Molecular cloning of human and mouse DJ-1 genes and identification of Sp1-dependent activation of the human DJ-1 promoter.Gene2001 Jan 24Taira T-
15935068DJ-1 is present in a large molecular complex in human brain tissue and interacts with alpha-synuclein.J Neurochem2005 JunMeulener MC-
14654946Up-regulated expression of the MAT-8 gene in prostate cancer and its siRNA-mediated inhibition of expression induces a decrease in proliferation of human prostate carcinoma cells.Int J Oncol2004 JanGrzmil M-
14583493Proteomic profiling drug-induced apoptosis in non-small cell lung carcinoma: identification of RS/DJ-1 and RhoGDIalpha.Cancer Res2003 Oct 15MacKeigan JP-
18626009RNA binding activity of the recessive parkinsonism protein DJ-1 supports involvement in multiple cellular pathways.Proc Natl Acad Sci U S A2008 Jul 22van der Brug MPdoi: 10.1073/pnas.0708518105
29675578The Parkinson's Disease-Linked Protein DJ-1 Associates with Cytoplasmic mRNP Granules During Stress and Neurodegeneration.Mol Neurobiol2019 JanRepici Mdoi: 10.1007/s12035-018-1084-y
15790595The Parkinson's disease-associated DJ-1 protein is a transcriptional co-activator that protects against neuronal apoptosis.Hum Mol Genet2005 May 1Xu J-
21368136Multiple coregulatory control of tyrosine hydroxylase gene transcription.Proc Natl Acad Sci U S A2011 Mar 8Reddy SDdoi: 10.1073/pnas.1101193108
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000377488PARK7-202783-ENSP00000366708189 (aa)-Q99497
ENST00000497113PARK7-210670--- (aa)--
ENST00000469225PARK7-207711-ENSP00000466756160 (aa)-K7EN27
ENST00000493373PARK7-208624-ENSP00000465404189 (aa)-Q99497
ENST00000493678PARK7-2091088-ENSP00000418770189 (aa)-Q99497
ENST00000338639PARK7-201949-ENSP00000340278189 (aa)-Q99497
ENST00000377493PARK7-204795-ENSP00000466242169 (aa)-K7ELW0
ENST00000460192PARK7-205567--- (aa)--
ENST00000377491PARK7-203977XM_005263424ENSP00000366711189 (aa)XP_005263481Q99497
ENST00000465354PARK7-206949--- (aa)--
Gene Model
Click here to download ENSG00000116288's gene model file
Pathways
Pathway IDPathway NameSource
hsa05012Parkinson diseaseKEGG
Phenotypes
ensgIDTraitpValuePubmed ID
ENSG00000116288Colitis, Ulcerative6E-1426192919
ENSG00000116288Colitis, Ulcerative5E-921297633
ENSG00000116288Crohn Disease5E-926192919
ENSG00000116288Inflammatory Bowel Diseases1E-1228067908
ENSG00000116288Stroke2E-724262325
ENSG00000116288Colitis, Ulcerative4E-928067908
ENSG00000116288Inflammatory Bowel Diseases1E-1523128233
ENSG00000116288Celiac Disease9E-820190752
ENSG00000116288Crohn Disease3E-628067908
GWAS
ensgIDSNPChromosomePositionSNP-risk TraitPubmedID95% CIOr or BEAT EFO ID
ENSG00000116288rs16180217982766?Ischemic stroke24262325[1.08-1.16]1.1111EFO_0000712
ENSG00000116288rs376660617962137CUlcerative colitis261929191.143554EFO_0000729
ENSG00000116288rs376660617962137ACrohn's disease261929191.1060587EFO_0000384
ENSG00000116288rs1752380217961680?Tonsillectomy28928442[0.033-0.076] unit increase0.0545EFO_0007924
ENSG00000116288rs376660617962137?Crohn's disease28067908EFO_0000384
ENSG00000116288rs376660617962137?Ulcerative colitis28067908EFO_0000729
ENSG00000116288rs376660617962137?Inflammatory bowel disease28067908EFO_0003767
ENSG00000116288rs3567566617961913GUlcerative colitis21297633[1.02-1.15]1.08EFO_0000729
ENSG00000116288rs3567566617961913GInflammatory bowel disease23128233[1.07-1.156]1.112EFO_0003767
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000116288's network

* RBP PPI network refers to all genes directly bind to RBP
Orthologs identified by RBPome
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000116288PARK710091.534ENSMUSG00000028964Park710095.238Mus_musculus
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0000785chromatin16731528.IDAComponent
GO:0001047core promoter binding15790595.ICFunction
GO:0001933negative regulation of protein phosphorylation15983381.IGIProcess
GO:0002866positive regulation of acute inflammatory response to antigenic stimulus-ISSProcess
GO:0003690double-stranded DNA binding22683601.IDAFunction
GO:0003697single-stranded DNA binding22683601.IDAFunction
GO:0003713transcription coactivator activity15790595.IGIFunction
GO:0003713transcription coactivator activity16731528.TASFunction
GO:0003729mRNA binding18626009.IDAFunction
GO:0005102signaling receptor binding21785459.IPIFunction
GO:0005507copper ion binding23792957.IDAFunction
GO:0005515protein binding11477070.15790595.15983381.16632486.17510388.19229105.19822128.20127688.21097510.21785459.22683601.23743200.24899725.24947010.25416956.IPIFunction
GO:0005634nucleus21630459.HDAComponent
GO:0005634nucleus21873635.IBAComponent
GO:0005634nucleus11477070.12446870.14662519.15790595.15983381.18711745.19822128.22683601.IDAComponent
GO:0005654nucleoplasm-TASComponent
GO:0005737cytoplasm12446870.15983381.17510388.18711745.19822128.IDAComponent
GO:0005739mitochondrion15790595.15944198.18711745.19229105.19822128.23743200.IDAComponent
GO:0005739mitochondrion21785459.IMPComponent
GO:0005747mitochondrial respiratory chain complex I19822128.IDAComponent
GO:0005758mitochondrial intermembrane space-IEAComponent
GO:0005759mitochondrial matrix-IEAComponent
GO:0005783endoplasmic reticulum-IEAComponent
GO:0005829cytosol21873635.IBAComponent
GO:0005829cytosol14662519.15944198.19229105.22683601.IDAComponent
GO:0005829cytosol21785459.IMPComponent
GO:0005886plasma membrane-IEAComponent
GO:0005913cell-cell adherens junction25468996.HDAComponent
GO:0006281DNA repair28596309.IDAProcess
GO:0006469negative regulation of protein kinase activity15983381.IGIProcess
GO:0006508proteolysis-IEAProcess
GO:0006517protein deglycosylation25416785.IDAProcess
GO:0006517protein deglycosylation27903648.IDAProcess
GO:0006517protein deglycosylation26995087.IMPProcess
GO:0006914autophagy-IEAProcess
GO:0006954inflammatory response-IEAProcess
GO:0007005mitochondrion organization-ISSProcess
GO:0007265Ras protein signal transduction14662519.TASProcess
GO:0007338single fertilization-IEAProcess
GO:0008134transcription factor binding21097510.IPIFunction
GO:0008233peptidase activity20304780.IDAFunction
GO:0008344adult locomotory behavior-IEAProcess
GO:0009438methylglyoxal metabolic process22523093.IDAProcess
GO:0009438methylglyoxal metabolic process27903648.IDAProcess
GO:0010273detoxification of copper ion23792957.IMPProcess
GO:0010628positive regulation of gene expression24252804.TASProcess
GO:0010629negative regulation of gene expression22683601.IDAProcess
GO:0016532superoxide dismutase copper chaperone activity24567322.IDAFunction
GO:0016605PML body22683601.IDAComponent
GO:0016684oxidoreductase activity, acting on peroxide as acceptor24567322.IDAFunction
GO:0018323enzyme active site formation via L-cysteine sulfinic acid-IEAProcess
GO:0019249lactate biosynthetic process22523093.IDAProcess
GO:0019899enzyme binding19703902.19822128.23743200.IPIFunction
GO:0019900kinase binding19229105.IPIFunction
GO:0019955cytokine binding21097510.IPIFunction
GO:0030073insulin secretion-ISSProcess
GO:0030424axon-ISSComponent
GO:0031397negative regulation of protein ubiquitination17015834.24899725.IDAProcess
GO:0032091negative regulation of protein binding11477070.16731528.17015834.24899725.IDAProcess
GO:0032091negative regulation of protein binding15983381.IGIProcess
GO:0032091negative regulation of protein binding21785459.IMPProcess
GO:0032148activation of protein kinase B activity22492997.ICProcess
GO:0032435negative regulation of proteasomal ubiquitin-dependent protein catabolic process17015834.IDAProcess
GO:0032757positive regulation of interleukin-8 production21097510.IDAProcess
GO:0033138positive regulation of peptidyl-serine phosphorylation22492997.IMPProcess
GO:0033234negative regulation of protein sumoylation16731528.IDAProcess
GO:0033864positive regulation of NAD(P)H oxidase activity-ISSProcess
GO:0034599cellular response to oxidative stress15983381.19703902.20969476.22683601.IDAProcess
GO:0034599cellular response to oxidative stress24899725.IMPProcess
GO:0036470tyrosine 3-monooxygenase activator activity19703902.IDAFunction
GO:0036471cellular response to glyoxal22523093.IDAProcess
GO:0036478L-dopa decarboxylase activator activity19703902.IDAFunction
GO:0036524protein deglycase activity21873635.IBAFunction
GO:0036524protein deglycase activity25416785.IDAFunction
GO:0036526peptidyl-cysteine deglycation25416785.IDAProcess
GO:0036527peptidyl-arginine deglycation25416785.IDAProcess
GO:0036528peptidyl-lysine deglycation25416785.IDAProcess
GO:0036529protein deglycation, glyoxal removal21873635.IBAProcess
GO:0036529protein deglycation, glyoxal removal25416785.IDAProcess
GO:0036530protein deglycation, methylglyoxal removal25416785.IDAProcess
GO:0036530protein deglycation, methylglyoxal removal27903648.IDAProcess
GO:0036531glutathione deglycation25416785.IDAProcess
GO:0042593glucose homeostasis-ISSProcess
GO:0042743hydrogen peroxide metabolic process20969476.24567322.IDAProcess
GO:0042802identical protein binding15502874.15983381.24947010.IPIFunction
GO:0042803protein homodimerization activity18711745.24144264.24567322.IDAFunction
GO:0043066negative regulation of apoptotic process22523093.IDAProcess
GO:0043523regulation of neuron apoptotic process18711745.20304780.IDAProcess
GO:0043524negative regulation of neuron apoptotic process22511790.IDAProcess
GO:0044297cell body-IEAComponent
GO:0044388small protein activating enzyme binding15983381.IPIFunction
GO:0044390ubiquitin-like protein conjugating enzyme binding15983381.IPIFunction
GO:0045121membrane raft-IEAComponent
GO:0045296cadherin binding25468996.HDAFunction
GO:0045340mercury ion binding23792957.IDAFunction
GO:0045560regulation of TRAIL receptor biosynthetic process21785459.IMPProcess
GO:0045944positive regulation of transcription by RNA polymerase II21097510.IDAProcess
GO:0045944positive regulation of transcription by RNA polymerase II15790595.17015834.IGIProcess
GO:0045944positive regulation of transcription by RNA polymerase II16731528.19703902.22492997.IMPProcess
GO:0046295glycolate biosynthetic process22523093.IDAProcess
GO:0046826negative regulation of protein export from nucleus15983381.IGIProcess
GO:0048471perinuclear region of cytoplasm25468996.IDAComponent
GO:0050681androgen receptor binding17510388.IPIFunction
GO:0050727regulation of inflammatory response-ISSProcess
GO:0050787detoxification of mercury ion23792957.IMPProcess
GO:0050821protein stabilization24947010.IDAProcess
GO:0050821protein stabilization17015834.19229105.IMPProcess
GO:0051091positive regulation of DNA-binding transcription factor activity17015834.IMPProcess
GO:0051091positive regulation of DNA-binding transcription factor activity22492997.TASProcess
GO:0051444negative regulation of ubiquitin-protein transferase activity24899725.IDAProcess
GO:0051583dopamine uptake involved in synaptic transmission-IEAProcess
GO:0051881regulation of mitochondrial membrane potential23743200.IMPProcess
GO:0051897positive regulation of protein kinase B signaling22492997.ICProcess
GO:0051899membrane depolarization-IEAProcess
GO:0051920peroxiredoxin activity-IEAFunction
GO:0060081membrane hyperpolarization-IEAProcess
GO:0060548negative regulation of cell death14749723.IDAProcess
GO:0060765regulation of androgen receptor signaling pathway11477070.IDAProcess
GO:0070062extracellular exosome19056867.19199708.20458337.23533145.HDAComponent
GO:0070301cellular response to hydrogen peroxide14749723.IDAProcess
GO:0070491repressing transcription factor binding15790595.16731528.IPIFunction
GO:0090073positive regulation of protein homodimerization activity24947010.IDAProcess
GO:0097110scaffold protein binding21785459.IPIFunction
GO:0098793presynapse-IEAComponent
GO:0098869cellular oxidant detoxification-IEAProcess
GO:0106044guanine deglycation28596309.IDAProcess
GO:0106045guanine deglycation, methylglyoxal removal28596309.IDAProcess
GO:0106046guanine deglycation, glyoxal removal21873635.IBAProcess
GO:0106046guanine deglycation, glyoxal removal28596309.IDAProcess
GO:1900182positive regulation of protein localization to nucleus21097510.IDAProcess
GO:1900182positive regulation of protein localization to nucleus22492997.IMPProcess
GO:1901215negative regulation of neuron death22683601.IDAProcess
GO:1901671positive regulation of superoxide dismutase activity24567322.IDAProcess
GO:1901984negative regulation of protein acetylation22683601.IDAProcess
GO:1902177positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway-IEAProcess
GO:1902236negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway14652021.IGIProcess
GO:1902903regulation of supramolecular fiber organization23626584.TASProcess
GO:1902958positive regulation of mitochondrial electron transport, NADH to ubiquinone19822128.IMPProcess
GO:1903073negative regulation of death-inducing signaling complex assembly21785459.ICProcess
GO:1903094negative regulation of protein K48-linked deubiquitination21097510.IDAProcess
GO:1903122negative regulation of TRAIL-activated apoptotic signaling pathway21785459.IMPProcess
GO:1903135cupric ion binding24567322.IDAFunction
GO:1903136cuprous ion binding24144264.24567322.IDAFunction
GO:1903168positive regulation of pyrroline-5-carboxylate reductase activity23743200.IDAProcess
GO:1903178positive regulation of tyrosine 3-monooxygenase activity19703902.IDAProcess
GO:1903181positive regulation of dopamine biosynthetic process16731528.ICProcess
GO:1903181positive regulation of dopamine biosynthetic process19703902.IDAProcess
GO:1903189glyoxal metabolic process22523093.IDAProcess
GO:1903197positive regulation of L-dopa biosynthetic process16731528.IMPProcess
GO:1903200positive regulation of L-dopa decarboxylase activity19703902.IDAProcess
GO:1903202negative regulation of oxidative stress-induced cell death16632486.IDAProcess
GO:1903206negative regulation of hydrogen peroxide-induced cell death22492997.23743200.IMPProcess
GO:1903208negative regulation of hydrogen peroxide-induced neuron death15983381.24947010.IDAProcess
GO:1903377negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway15790595.IDAProcess
GO:1903384negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway14652021.IGIProcess
GO:1903427negative regulation of reactive oxygen species biosynthetic process-ISSProcess
GO:1903428positive regulation of reactive oxygen species biosynthetic process-IEAProcess
GO:1903599positive regulation of autophagy of mitochondrion24531622.NASProcess
GO:1905259negative regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway14752510.IDAProcess
GO:1990381ubiquitin-specific protease binding21097510.IPIFunction
GO:2000157negative regulation of ubiquitin-specific protease activity21097510.IDAProcess
GO:2000277positive regulation of oxidative phosphorylation uncoupler activity-IEAProcess
GO:2000679positive regulation of transcription regulatory region DNA binding22492997.IMPProcess
GO:2000825positive regulation of androgen receptor activity17510388.IMPProcess
GO:2001237negative regulation of extrinsic apoptotic signaling pathway21785459.IMPProcess
GO:2001268negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway21785459.IMPProcess
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