EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
28298474	Tumor protein D52 expression is post-transcriptionally regulated by T-cell intercellular antigen (TIA) 1 and TIA-related protein via mRNA stability.	Biochem J	2017 May 4	Motohashi H	doi: 10.1042/BCJ20160942.
12949814	Increased TIA-1 gene expression in the tumor microenvironment after locoregional administration of tumor necrosis factor-alpha to patients with soft tissue limb sarcoma.	Int J Cancer	2003 Nov 1	Mocellin S	-
28257633	miR-19a promotes colorectal cancer proliferation and migration by targeting TIA1.	Mol Cancer	2017 Mar 4	Liu Y	doi: 10.1186/s12943-017-0625-8.
29496454	Potential use of TIA-1, MFF, microRNA-200a-3p, and microRNA-27 as a novel marker for hepatocellular carcinoma.	Biochem Biophys Res Commun	2018 Mar 18	Tak H	doi: 10.1016/j.bbrc.2018.02.189
21179245	TIA-1 cytotoxic granule-associated RNA binding protein improves the prognostic performance of CD8 in mismatch repair-proficient colorectal cancer.	PLoS One	2010 Dec 10	Zlobec I	doi: 10.1371/journal.pone.0014282.
25224594	Alternative splicing of TIA-1 in human colon cancer regulates VEGF isoform expression, angiogenesis, tumour growth and bevacizumab resistance.	Mol Oncol	2015 Jan	Hamdollah Zadeh MA	doi: 10.1016/j.molonc.2014.07.017
28174264	Hippo signaling promotes JNK-dependent cell migration.	Proc Natl Acad Sci U S A	2017 Feb 21	Ma X	doi: 10.1073/pnas.1621359114

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
BLCA	chr2	70212713	3'UTR	novel		0.15
BLCA	chr2	70248421	Missense_Mutation	novel	E4K	0.39	RRM_1
BRCA	chr2	70211753	3'UTR	novel		0.2
BRCA	chr2	70214463	Missense_Mutation	novel	G307V	0.19
BRCA	chr2	70227814	Missense_Mutation	NA	H107Y	0.29
BRCA	chr2	70215394	Missense_Mutation	NA	D289H	0.19
BRCA	chr2	70212821	Missense_Mutation	NA	W353C	0.4
BRCA	chr2	70229103	Intron	novel		0.13
BRCA	chr2	70229283	Frame_Shift_Ins	novel	*S86Rfs11**	0.03
BRCA	chr2	70229285	Nonsense_Mutation	novel	S86*	0.02
CESC	chr2	70227794	Silent	novel	L113L	0.32
CESC	chr2	70211665	3'UTR	novel		0.34
CESC	chr2	70227734	Splice_Site	NA	X133_splice	0.46
CHOL	chr2	70212317	3'UTR	novel		0.28
COAD	chr2	70216919	Nonsense_Mutation	novel	R184*	0.13
COAD	chr2	70216750	Intron	novel		0.38
COAD	chr2	70236173	Missense_Mutation	novel	Y10C	0.41	RRM_1
COAD	chr2	70216907	Missense_Mutation	rs756853891	A188T	0.41
COAD	chr2	70216242	Nonsense_Mutation	NA	R244*	0.44
ESCA	chr2	70215471	Missense_Mutation	novel	A263V	0.38
ESCA	chr2	70212137	3'UTR	novel		0.16
ESCA	chr2	70216789	Intron	rs749416525		0.14
GBM	chr2	70212502	3'UTR	novel		0.59
GBM	chr2	70248418	Missense_Mutation	novel	M5V	0.25	RRM_1
GBM	chr2	70216262	Missense_Mutation	novel	F237C	0.25
GBM	chr2	70230819	Frame_Shift_Del	novel	*H54Mfs10**	0.33
HNSC	chr2	70224555	Nonsense_Mutation	novel	W158*	0.24
HNSC	chr2	70216868	Intron	novel		0.15
KIRC	chr2	70214406	Missense_Mutation	NA	G326A	0.32
KIRP	chr2	70229189	Intron	novel		0.5
LGG	chr2	70212657	3'UTR	novel		0.06
LGG	chr2	70227824	Splice_Site	novel	X104_splice	0.38
LIHC	chr2	70216747	Intron	novel		0.29
LIHC	chr2	70229031	Intron	novel		0.08
LUAD	chr2	70212633	3'UTR	novel		0.07
LUAD	chr2	70224617	Silent	NA	V137V	0.15
LUAD	chr2	70216873	Intron	novel		0.03
LUAD	chr2	70227767	Silent	NA	I122I	0.14
LUAD	chr2	70230835	Missense_Mutation	rs370430518	Y48C	0.06	RRM_1
LUSC	chr2	70224557	Missense_Mutation	novel	K157N	0.15
LUSC	chr2	70227750	Missense_Mutation	novel	P128L	0.18
LUSC	chr2	70230788	Missense_Mutation	NA	A64P	0.24
LUSC	chr2	70236138	Missense_Mutation	novel	L22V	0.15	RRM_1
LUSC	chr2	70224603	Missense_Mutation	rs372738231	A142V	0.35
LUSC	chr2	70214394	Missense_Mutation	NA	P330L	0.29
LUSC	chr2	70216241	Missense_Mutation	rs777224522	R244Q	0.48
LUSC	chr2	70229220	Intron	novel		0.15
LUSC	chr2	70229290	Missense_Mutation	NA	P84R	0.06
OV	chr2	70229001	Intron	novel		0.13
OV	chr2	70216808	Intron	rs776382911		0.03
PRAD	chr2	70212744	Missense_Mutation	rs774014016	R379Q	0.21
PRAD	chr2	70236148	Silent	novel	V18V	0.31
READ	chr2	70216855	Intron	NA		0.48
READ	chr2	70216209	Missense_Mutation	NA	R255W	0.46
SARC	chr2	70216807	Intron	rs770780884		0.82
SARC	chr2	70214485	Frame_Shift_Del	novel	*I300Lfs89**	0.89
SKCM	chr2	70214413	Missense_Mutation	novel	P324S	0.22
SKCM	chr2	70229291	Missense_Mutation	novel	P84S	0.2
SKCM	chr2	70216908	Silent	rs533863358	P187P	0.22
SKCM	chr2	70229162	Intron	novel		0.31
SKCM	chr2	70224563	Frame_Shift_Ins	novel	*N156Qfs6**	0.41
SKCM	chr2	70230837	Silent	NA	P47P	0.41
SKCM	chr2	70229012	Intron	novel		0.16
SKCM	chr2	70224622	Nonsense_Mutation	NA	R136*	0.33
SKCM	chr2	70229130	Intron	novel		0.2
SKCM	chr2	70216432	Nonsense_Mutation	novel	Y217*	0.1
SKCM	chr2	70212687	3'UTR	novel		0.18
SKCM	chr2	70227735	Missense_Mutation	rs375191972	S133L	0.63
SKCM	chr2	70227815	Silent	rs770120862	F106F	0.4
STAD	chr2	70227735	Missense_Mutation	rs375191972	S133L	0.37
STAD	chr2	70214370	Missense_Mutation	NA	A338V	0.33
STAD	chr2	70214419	Missense_Mutation	NA	Y322H	0.24
STAD	chr2	70216882	Splice_Region	novel		0.36
STAD	chr2	70227759	Missense_Mutation	NA	A125V	0.22
STAD	chr2	70212714	3'UTR	novel		0.18
STAD	chr2	70216936	Missense_Mutation	novel	R178K	0.06
STAD	chr2	70216854	Intron	novel		0.21
STAD	chr2	70212534	3'UTR	novel		0.28
STAD	chr2	70227734	Splice_Site	NA	X133_splice	0.29
UCEC	chr2	70215419	Silent	novel	K280K	0.38
UCEC	chr2	70227735	Nonsense_Mutation	novel	S133*	0.1
UCEC	chr2	70236168	Missense_Mutation	NA	G12S	0.22	RRM_1
UCEC	chr2	70212709	3'UTR	novel		0.12
UCEC	chr2	70216205	Splice_Region	novel		0.39
UCEC	chr2	70229254	Intron	novel		0.46
UCEC	chr2	70230814	Missense_Mutation	novel	E55G	0.3
UCEC	chr2	70216965	Silent	NA	G168G	0.33
UCEC	chr2	70248411	Missense_Mutation	novel	K7T	0.5	RRM_1
UCEC	chr2	70211674	3'UTR	novel		0.35
UCEC	chr2	70216281	Missense_Mutation	rs752346516	R231C	0.4
UCEC	chr2	70212244	3'UTR	novel		0.29
UCEC	chr2	70212436	3'UTR	novel		0.44
UCEC	chr2	70216746	Intron	novel		0.36
UCEC	chr2	70230808	Missense_Mutation	rs778629190	R57H	0.37
UCEC	chr2	70229201	Intron	novel		0.4
UCEC	chr2	70248444	5'UTR	novel		0.45
UCEC	chr2	70212545	3'UTR	novel		0.5
UCEC	chr2	70248496	5'UTR	novel		0.23
UCEC	chr2	70229083	Missense_Mutation	NA	V96I	0.33
UCEC	chr2	70212010	3'UTR	novel		0.35
UCEC	chr2	70212677	3'UTR	novel		0.22
UCEC	chr2	70228988	Intron	novel		0.43
UCEC	chr2	70212233	3'UTR	novel		0.09
UCEC	chr2	70236091	Missense_Mutation	NA	K37N	0.23	RRM_1
UCEC	chr2	70216909	Missense_Mutation	novel	P187H	0.12
UCEC	chr2	70229199	Intron	novel		0.1
UCEC	chr2	70248497	5'UTR	novel		0.29
UCEC	chr2	70211696	3'UTR	novel		0.5
UCEC	chr2	70212195	3'UTR	novel		0.46
UCEC	chr2	70212235	3'UTR	novel		0.15
UCEC	chr2	70229085	Missense_Mutation	novel	T95I	0.38
UCS	chr2	70214360	Missense_Mutation	novel	Q341H	0.4

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
KIRP	DEL	0.0278	0.08832
PAAD	DEL	0.0489	0.2014
READ	DEL	0.0667	0.19022

Survival Analysis

Cancer	P-value	Q-value
THYM	0.0019	Kaplan-Meier Survival Analysis
KIRC	0.0001	Kaplan-Meier Survival Analysis
SARC	0.03	Kaplan-Meier Survival Analysis
ACC	0.00011	Kaplan-Meier Survival Analysis
HNSC	0.0014	Kaplan-Meier Survival Analysis
SKCM	0.00024	Kaplan-Meier Survival Analysis
PRAD	0.038	Kaplan-Meier Survival Analysis
BLCA	0.0001	Kaplan-Meier Survival Analysis
LAML	0.0082	Kaplan-Meier Survival Analysis
GBM	0.0013	Kaplan-Meier Survival Analysis
LIHC	0.0047	Kaplan-Meier Survival Analysis
LGG	0.0045	Kaplan-Meier Survival Analysis
LUAD	0.0086	Kaplan-Meier Survival Analysis
UVM	0.014	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBDs

RBPome

PRI

Literatures

Expression

Transcripts

Gene Model

GWAS

PPI

Paralog

Ortholog

Gene Ontology

Description

Ensembl ID: ENSG00000116001 (Gene tree)
Gene ID: 7072
Gene Symbol: TIA1
Alias: N
Full Name: TIA1 cytotoxic granule associated RNA binding protein
Gene Type: protein_coding
Specie: Homo_sapiens
Strand: Minus strand
Length: 39,264 bases
Position: chr2:70,209,444-70,248,707
Accession: 11802
Summary: The product encoded by this gene is a member of a RNA-binding protein family and possesses nucleolytic activity against cytotoxic lymphocyte (CTL) target cells. It has been suggested that this protein may be involved in the induction of apoptosis as it preferentially recognizes poly(A) homopolymers and induces DNA fragmentation in CTL targets. The major granule-associated species is a 15-kDa protein that is thought to be derived from the carboxyl terminus of the 40-kDa product by proteolytic processing. Alternative splicing resulting in different isoforms has been found for this gene. [provided by RefSeq, May 2017]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000404023	RRM_1	PF00076.22	2.5e-67	1	3
ENSP00000404023	RRM_1	PF00076.22	2.5e-67	2	3
ENSP00000404023	RRM_1	PF00076.22	2.5e-67	3	3
ENSP00000282574	RRM_1	PF00076.22	2.8e-67	1	3
ENSP00000282574	RRM_1	PF00076.22	2.8e-67	2	3
ENSP00000282574	RRM_1	PF00076.22	2.8e-67	3	3
ENSP00000401371	RRM_1	PF00076.22	2.8e-67	1	3
ENSP00000401371	RRM_1	PF00076.22	2.8e-67	2	3
ENSP00000401371	RRM_1	PF00076.22	2.8e-67	3	3
ENSP00000399567	RRM_1	PF00076.22	4.7e-58	1	3
ENSP00000399567	RRM_1	PF00076.22	4.7e-58	2	3
ENSP00000399567	RRM_1	PF00076.22	4.7e-58	3	3
ENSP00000413751	RRM_1	PF00076.22	7e-48	1	2
ENSP00000413751	RRM_1	PF00076.22	7e-48	2	2
ENSP00000354838	RRM_1	PF00076.22	1e-39	1	2
ENSP00000354838	RRM_1	PF00076.22	1e-39	2	2
ENSP00000402263	RRM_1	PF00076.22	3.2e-13	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	PolyT & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	polyT & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
27453046	Comprehensive Identification of RNA-Binding Domains in Human Cells	PolyT & Hela	2016 Aug 18	Castello A	DOI: 10.1016/j.molcel.2016.06.029
30352994	Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome capture	RIC & Jurkat	2018 Oct 23	Perez-Perri JI	DOI:10.1038/s41467-018-06557-8

RNA-binding sites

Click here to download all RNA binding sites

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
28980860	behavior of proteins involved in amyotrophic lateral sclerosis and frontotemporal lobar degeneration.	Autophagy	2017	Uversky VN	doi: 10.1080/15548627.2017.1384889
22115364	Alternative splicing of the neurofibromatosis typeI pre-mRNA.	Biosci Rep	2012 Apr 1	Barron VA	doi: 10.1042/BSR20110060.
10613902	RNA-binding proteins TIA-1 and TIAR link the phosphorylation of eIF-2 alpha to the assembly of mammalian stress granules.	J Cell Biol	1999 Dec 27	Kedersha NL	-
19605462	NMR solution structure of HP0827 (O25501_HELPY) from Helicobacter pylori: model of the possible RNA-binding site.	J Biochem	2009 Nov	Jang SB	doi: 10.1093/jb/mvp105
22175897	Revising the historical collection of epithelioid cell-rich lymphomas of the Kiel Lymph Node Registry: what is Lennert's lymphoma nowadays?	Histopathology	2011 Dec	Hartmann S	doi: 10.1111/j.1365-2559.2011.04069.x.
25108040	Pathological stress granules in Alzheimer's disease.	Brain Res	2014 Oct 10	Ash PE	doi: 10.1016/j.brainres.2014.05.052
30126736	Subcutaneous panniculitis-like T-cell lymphoma: Clinical features, therapeutic approach, and outcome in a case series of 16 patients.	J Am Acad Dermatol	2018 Nov	Lopez-Lerma I	doi: 10.1016/j.jaad.2018.05.1243
12885872	Regulation of cyclooxygenase-2 expression by the translational silencer TIA-1.	J Exp Med	2003 Aug 4	Dixon DA	-
18562690	JunD represses transcription and translation of the tight junction protein zona occludens-1 modulating intestinal epithelial barrier function.	Mol Biol Cell	2008 Sep	Chen J	doi: 10.1091/mbc.E08-02-0175
22619362	Frequent gain and loss of intronic splicing regulatory elements during the evolution of vertebrates.	Genome Biol Evol	2012	Voelker RB	doi: 10.1093/gbe/evs051
30367664	Formation of Toxic Oligomeric Assemblies of RNA-binding Protein: Musashi in Alzheimer's disease.	Acta Neuropathol Commun	2018 Oct 26	Sengupta U	doi: 10.1186/s40478-018-0615-0.
8871565	Structure, tissue distribution and genomic organization of the murine RRM-type RNA binding proteins TIA-1 and TIAR.	Nucleic Acids Res	1996 Oct 1	Beck AR	-
8570616	Characterization of GMP-17, a granule membrane protein that moves to the plasma membrane of natural killer cells following target cell recognition.	Proc Natl Acad Sci U S A	1996 Jan 23	Medley QG	-
8576255	Individual RNA recognition motifs of TIA-1 and TIAR have different RNA binding specificities.	J Biol Chem	1996 Feb 2	Dember LM	-
16527256	Identification of FUSE-binding proteins as interacting partners of TIA proteins.	Biochem Biophys Res Commun	2006 Apr 28	Rothe F	-
12414941	Cell proteins TIA-1 and TIAR interact with the 3' stem-loop of the West Nile virus complementary minus-strand RNA and facilitate virus replication.	J Virol	2002 Dec	Li W	-
16278295	Identification of the sequence determinants mediating the nucleo-cytoplasmic shuttling of TIAR and TIA-1 RNA-binding proteins.	J Cell Sci	2005 Dec 1	Zhang T	-
14662769	Identification of RNA-binding proteins in RAW 264.7 cells that recognize a lipopolysaccharide-responsive element in the 3-untranslated region of the murine cyclooxygenase-2 mRNA.	J Biol Chem	2004 Feb 27	Cok SJ	-
19709424	Depletion of T-cell intracellular antigen proteins promotes cell proliferation.	Genome Biol	2009	Reyes R	doi: 10.1186/gb-2009-10-8-r87
18490444	MKP-1 mRNA stabilization and translational control by RNA-binding proteins HuR and NF90.	Mol Cell Biol	2008 Jul	Kuwano Y	doi: 10.1128/MCB.00165-08
17488725	Two isoforms of the T-cell intracellular antigen 1 (TIA-1) splicing factor display distinct splicing regulation activities. Control of TIA-1 isoform ratio by TIA-1-related protein.	J Biol Chem	2007 Jul 6	Izquierdo JM	-
20596534	Impaired embryonic development in mice overexpressing the RNA-binding protein TIAR.	PLoS One	2010 Jun 28	Kharraz Y	doi: 10.1371/journal.pone.0011352.
20477871	The splicing factor ASF/SF2 is associated with TIA-1-related/TIA-1-containing ribonucleoproteic complexes and contributes to post-transcriptional repression of gene expression.	FEBS J	2010 Jun	Delestienne N	doi: 10.1111/j.1742-4658.2010.07664.x
24824036	The binding of TIA-1 to RNA C-rich sequences is driven by its C-terminal RRM domain.	RNA Biol	2014	Cruz-Gallardo I	-
24682828	Structure, dynamics and RNA binding of the multi-domain splicing factor TIA-1.	Nucleic Acids Res	2014 May	Wang I	doi: 10.1093/nar/gku193
23902765	RNA binding of T-cell intracellular antigen-1 (TIA-1) C-terminal RNA recognition motif is modified by pH conditions.	J Biol Chem	2013 Sep 6	Cruz-Gallardo I	doi: 10.1074/jbc.M113.489070
26981431	Genome-wide analysis of TIAR RNA ligands in mouse macrophages before and after LPS stimulation.	Genom Data	2016 Feb 8	Kharraz Y	doi: 10.1016/j.gdata.2016.02.007
28904350	Tia1 dependent regulation of mRNA subcellular location and translation controls p53 expression in B cells.	Nat Commun	2017 Sep 13	Diaz-Munoz MD	doi: 10.1038/s41467-017-00454-2.
1934064	A polyadenylate binding protein localized to the granules of cytolytic lymphocytes induces DNA fragmentation in target cells.	Cell	1991 Nov 1	Tian Q	-
11121440	Dynamic shuttling of TIA-1 accompanies the recruitment of mRNA to mammalian stress granules.	J Cell Biol	2000 Dec 11	Kedersha N	-
16775137	Dendritic localization of the translational repressor Pumilio 2 and its contribution to dendritic stress granules.	J Neurosci	2006 Jun 14	Vessey JP	-
18927617	Hepatic transcriptome analysis of hepatitis C virus infection in chimpanzees defines unique gene expression patterns associated with viral clearance.	PLoS One	2008	Nanda S	doi: 10.1371/journal.pone.0003442
18005751	Inhibition of cytoplasmic mRNA stress granule formation by a viral proteinase.	Cell Host Microbe	2007 Nov 15	White JP	-
21654213	Alternative splicing in spinal muscular atrophy underscores the role of an intron definition model.	RNA Biol	2011 Jul-Aug	Singh NN	doi: 10.4161/rna.8.4.16224
30327138	Transcriptome meta-analysis identifies immune signature comprising of RNA binding proteins in ulcerative colitis patients.	Cell Immunol	2018 Dec	Naz S	doi: 10.1016/j.cellimm.2018.09.003
7533298	The RNA-binding protein TIAR is translocated from the nucleus to the cytoplasm during Fas-mediated apoptotic cell death.	Proc Natl Acad Sci U S A	1995 Feb 28	Taupin JL	-
7544399	Fas-activated serine/threonine kinase (FAST) phosphorylates TIA-1 during Fas-mediated apoptosis.	J Exp Med	1995 Sep 1	Tian Q	-
7512092	Expression of perforin, granzyme A and TIA-1 by human uterine CD56+ NK cells implies they are activated and capable of effector functions.	Hum Reprod	1993 Dec	King A	-
1326761	Identification and functional characterization of a TIA-1-related nucleolysin.	Proc Natl Acad Sci U S A	1992 Sep 15	Kawakami A	-
8759725	Expression of the CTL-associated protein TIA-1 during murine embryogenesis.	J Immunol	1996 Aug 15	Lowin B	-
8396236	The developmentally-regulated Drosophila gene rox8 encodes an RRM-type RNA binding protein structurally related to human TIA-1-type nucleolysins.	Nucleic Acids Res	1993 Aug 11	Brand S	-
8176212	Intron-exon organization and chromosomal localization of the human TIA-1 gene.	J Immunol	1994 May 15	Kawakami A	-
7890163	Novel Drosophila melanogaster genes encoding RRM-type RNA-binding proteins identified by a degenerate PCR strategy.	Gene	1995 Mar 10	Brand SF	-
16581801	Translational control of cytochrome c by RNA-binding proteins TIA-1 and HuR.	Mol Cell Biol	2006 Apr	Kawai T	-
12949814	Increased TIA-1 gene expression in the tumor microenvironment after locoregional administration of tumor necrosis factor-alpha to patients with soft tissue limb sarcoma.	Int J Cancer	2003 Nov 1	Mocellin S	-
12533540	TIA-1 or TIAR is required for DT40 cell viability.	J Biol Chem	2003 Mar 21	Le Guiner C	-
12440953	AU-rich element-mediated translational control: complexity and multiple activities of trans-activating factors.	Biochem Soc Trans	2002 Nov	Zhang T	-
12380690	Visibly stressed: the role of eIF2, TIA-1, and stress granules in protein translation.	Cell Stress Chaperones	2002 Apr	Anderson P	-
12140254	Stressful initiations.	J Cell Sci	2002 Aug 15	Anderson P	-
11809833	Evidence that ternary complex (eIF2-GTP-tRNA(i)(Met))-deficient preinitiation complexes are core constituents of mammalian stress granules.	Mol Biol Cell	2002 Jan	Kedersha N	-
11359930	Accumulation of mutant huntingtin fragments in aggresome-like inclusion bodies as a result of insufficient protein degradation.	Mol Biol Cell	2001 May	Waelter S	-
10936786	Intra-tumoral cytolytic cells: pattern of distribution in B-cell non Hodgkin s lymphoma.	Pathol Oncol Res	2000	Perambakam S	-
10938105	The RNA-binding protein TIA-1 is a novel mammalian splicing regulator acting through intron sequences adjacent to a 5' splice site.	Mol Cell Biol	2000 Sep	Del Gatto-Konczak F	-
16890199	Control of the ATP synthase beta subunit expression by RNA-binding proteins TIA-1, TIAR, and HuR.	Biochem Biophys Res Commun	2006 Sep 22	Izquierdo JM	-
16221671	Mammalian Smaug is a translational repressor that forms cytoplasmic foci similar to stress granules.	J Biol Chem	2005 Dec 30	Baez MV	-
16227602	Identification and functional outcome of mRNAs associated with RNA-binding protein TIA-1.	Mol Cell Biol	2005 Nov	Lopez de Silanes I	-
15371533	Stress granule assembly is mediated by prion-like aggregation of TIA-1.	Mol Biol Cell	2004 Dec	Gilks N	-
14597390	De novo gene expression and antisense inhibition in cultured cells of BmTRN-1, cloned from the midgut of the silkworm, Bombyx mori, which is homologous with mammalian TIA-1/R.	Gene	2003 Nov 27	Kotani E	-
23401021	Welander distal myopathy is caused by a mutation in the RNA-binding protein TIA1.	Ann Neurol	2013 Apr	Hackman P	doi: 10.1002/ana.23831
23077311	Induction of stress granule-like structures in vesicular stomatitis virus-infected cells.	J Virol	2013 Jan	Dinh PX	doi: 10.1128/JVI.02305-12
19819975	Characterization of conserved tandem donor sites and intronic motifs required for alternative splicing in corticosteroid receptor genes.	Endocrinology	2009 Nov	Rivers C	doi: 10.1210/en.2009-0346
19386911	Cross-seeding fibrillation of Q/N-rich proteins offers new pathomechanism of polyglutamine diseases.	J Neurosci	2009 Apr 22	Furukawa Y	doi: 10.1523/JNEUROSCI.0783-09.2009.
19318808	Primary cutaneous peripheral T-cell lymphoma with aberrant coexpression of CD20: case report and review of the literature.	Am J Dermatopathol	2009 Apr	Balmer NN	doi: 10.1097/DAD.0b013e31818cc039.
19270389	Molecular characterization of a TIA-1-like RNA-binding protein in cells derived from the fall armyworm Spodoptera frugiperda (Lepidoptera: Noctuidae).	Biosci Biotechnol Biochem	2009 Mar 23	Muto S	-
18456862	A systematic analysis of intronic sequences downstream of 5' splice sites reveals a widespread role for U-rich motifs and TIA1/TIAL1 proteins in alternative splicing regulation.	Genome Res	2008 Aug	Aznarez I	doi: 10.1101/gr.073155.107
17580305	Nuclear protein TIA-1 regulates COL2A1 alternative splicing and interacts with precursor mRNA and genomic DNA.	J Biol Chem	2007 Aug 17	McAlinden A	-
17466948	The RNA-binding protein PTB exerts translational control on 3'-untranslated region of the mRNA for the ATP synthase beta-subunit.	Biochem Biophys Res Commun	2007 Jun 15	Reyes R	-
17209421	[Stress granules: RNP-containing cytoplasmic bodies springing up under stress. The structure and mechanism of organization].	Mol Biol (Mosk)	2006 Nov-Dec	Ivanov PA	-
17074806	Apigenin prevents UVB-induced cyclooxygenase 2 expression: coupled mRNA stabilization and translational inhibition.	Mol Cell Biol	2007 Jan	Tong X	-
22154808	Three RNA recognition motifs participate in RNA recognition and structural organization by the pro-apoptotic factor TIA-1.	J Mol Biol	2012 Jan 27	Bauer WJ	doi: 10.1016/j.jmb.2011.11.040
21957303	Poliovirus unlinks TIA1 aggregation and mRNA stress granule formation.	J Virol	2011 Dec	White JP	doi: 10.1128/JVI.05888-11
21846467	A structural insight into the C-terminal RNA recognition motifs of T-cell intracellular antigen-1 protein.	FEBS Lett	2011 Oct 3	Aroca A	doi: 10.1016/j.febslet.2011.07.037
21347286	RNA binding protein CUGBP2/CELF2 mediates curcumin-induced mitotic catastrophe of pancreatic cancer cells.	PLoS One	2011 Feb 11	Subramaniam D	doi: 10.1371/journal.pone.0016958.
21261285	Large favorable enthalpy changes drive specific RNA recognition by RNA recognition motif proteins.	Biochemistry	2011 Mar 8	McLaughlin KJ	doi: 10.1021/bi102057m
21179245	TIA-1 cytotoxic granule-associated RNA binding protein improves the prognostic performance of CD8 in mismatch repair-proficient colorectal cancer.	PLoS One	2010 Dec 10	Zlobec I	doi: 10.1371/journal.pone.0014282.
23213403	Wnt signalling antagonizes stress granule assembly through a Dishevelled-dependent mechanism.	Biol Open	2012 Feb 15	Sahoo PK	doi: 10.1242/bio.2011023
20453113	mRNA escape from stress granule sequestration is dictated by localization to the endoplasmic reticulum.	FASEB J	2010 Sep	Unsworth H	doi: 10.1096/fj.09-151142
25519906	Post-transcriptional regulation of programmed cell death 4 (PDCD4) mRNA by the RNA-binding proteins human antigen R (HuR) and T-cell intracellular antigen 1 (TIA1).	J Biol Chem	2015 Feb 6	Wigington CP	doi: 10.1074/jbc.M114.631937
25461769	TIA1 interacts with annexin A7 in regulating vascular endothelial cell autophagy.	Int J Biochem Cell Biol	2014 Dec	Huang S	doi: 10.1016/j.biocel.2014.10.015
25013173	Free mRNA in excess upon polysome dissociation is a scaffold for protein multimerization to form stress granules.	Nucleic Acids Res	2014 Jul	Bounedjah O	doi: 10.1093/nar/gku582
24879147	Identification of a novel MTOR activator and discovery of a competing endogenous RNA regulating autophagy in vascular endothelial cells.	Autophagy	2014 Jun	Ge D	doi: 10.4161/auto.28363.
27160897	Interaction of tau with the RNA-Binding Protein TIA1 Regulates tau Pathophysiology and Toxicity.	Cell Rep	2016 May 17	Vanderweyde T	doi: 10.1016/j.celrep.2016.04.045
24696465	The stress granule component TIA-1 binds tick-borne encephalitis virus RNA and is recruited to perinuclear sites of viral replication to inhibit viral translation.	J Virol	2014 Jun	Albornoz A	doi: 10.1128/JVI.03736-13
24627160	Oxygen sufficiency controls TOP mRNA translation via the TSC-Rheb-mTOR pathway in a 4E-BP-independent manner.	J Mol Cell Biol	2014 Jun	Miloslavski R	doi: 10.1093/jmcb/mju008
24590458	The involvement of mRNA processing factors TIA-1, TIAR, and PABP-1 during mammalian hibernation.	Cell Stress Chaperones	2014 Nov	Tessier SN	doi: 10.1007/s12192-014-0505-8
24566137	HuR and TIA1/TIAL1 are involved in regulation of alternative splicing of SIRT1 pre-mRNA.	Int J Mol Sci	2014 Feb 20	Zhao W	doi: 10.3390/ijms15022946.
27371730	Long Noncoding RNA MALAT1 Promotes Aggressive Pancreatic Cancer Proliferation and Metastasis via the Stimulation of Autophagy.	Mol Cancer Ther	2016 Sep	Li L	doi: 10.1158/1535-7163.MCT-16-0008
28221306	Whole Exome Sequencing Identifies Atypical Welander Distal Myopathy in Patient.	J Clin Neuromuscul Dis	2017 Mar	Gass J	doi: 10.1097/CND.0000000000000164.
26958940	Tumor-promoting function and prognostic significance of the RNA-binding protein T-cell intracellular antigen-1 in esophageal squamous cell carcinoma.	Oncotarget	2016 Mar 29	Hamada J	doi: 10.18632/oncotarget.7937.
26865701	The Stress Granule RNA-Binding Protein TIAR-1 Protects Female Germ Cells from Heat Shock in Caenorhabditis elegans.	G3 (Bethesda)	2016 Apr 7	Huelgas-Morales G	doi: 10.1534/g3.115.026815.
25797890	Active immunosurveillance in the tumor microenvironment of colorectal cancer is associated with low frequency tumor budding and improved outcome.	Transl Res	2015 Aug	Koelzer VH	doi: 10.1016/j.trsl.2015.02.008
29273772	Reducing the RNA binding protein TIA1 protects against tau-mediated neurodegeneration in vivo.	Nat Neurosci	2018 Jan	Apicco DJ	doi: 10.1038/s41593-017-0022-z
29298433	TIA-1 Self-Multimerization, Phase Separation, and Recruitment into Stress Granules Are Dynamically Regulated by Zn2.	Cell Rep	2018 Jan 2	Rayman JB	doi: 10.1016/j.celrep.2017.12.036.
29337236	Maintenance of the Innate Seizure Threshold by Cyclooxygenase-2 is Not Influenced by the Translational Silencer, T-cell Intracellular Antigen-1.	Neuroscience	2018 Mar 1	Gong Y	doi: 10.1016/j.neuroscience.2018.01.004
29370934	Mutation analysis of the TIA1 gene in Chinese patients with amyotrophic lateral sclerosis and frontotemporal dementia.	Neurobiol Aging	2018 Apr	Yuan Z	doi: 10.1016/j.neurobiolaging.2017.12.017
29429924	The TIA1 RNA-Binding Protein Family Regulates EIF2AK2-Mediated Stress Response and Cell Cycle Progression.	Mol Cell	2018 Feb 15	Meyer C	doi: 10.1016/j.molcel.2018.01.011.
29621237	Amino acid starvation sensing dampens IL-1β production by activating riboclustering and autophagy.	PLoS Biol	2018 Apr 5	Battu S	doi: 10.1371/journal.pbio.2005317
29891946	Cellular stress alters 3'UTR landscape through alternative polyadenylation and isoform-specific degradation.	Nat Commun	2018 Jun 11	Zheng D	doi: 10.1038/s41467-018-04730-7.
30157547	RNA-Binding Proteins in Amyotrophic Lateral Sclerosis.	Mol Cells	2018 Sep 30	Zhao M	doi: 10.14348/molcells.2018.0243
30348840	A Heterologous Cell Model for Studying the Role of T-Cell Intracellular Antigen 1 in Welander Distal Myopathy.	Mol Cell Biol	2018 Dec 11	Carrascoso I	doi: 10.1128/MCB.00299-18
30533021	Transcriptome-wide analysis links the short-term expression of the b isoforms of TIA proteins to protective proteostasis-mediated cell quiescence response.	PLoS One	2018 Dec 11	Carrascoso I	doi: 10.1371/journal.pone.0208526
30865887	Genetic Perturbation of TIA1 Reveals a Physiological Role in Fear Memory.	Cell Rep	2019 Mar 12	Rayman JB	doi: 10.1016/j.celrep.2019.02.048.
31138677	New roles for the de-ubiquitylating enzyme OTUD4 in an RNA-protein network and RNA granules.	J Cell Sci	2019 Jun 17	Das R	doi: 10.1242/jcs.229252.
31332267	USP10 is a critical factor for Tau-positive stress granule formation in neuronal cells.	Sci Rep	2019 Jul 22	Piatnitskaia S	doi: 10.1038/s41598-019-47033-7.
27749929	Rabies Virus Infection Induces the Formation of Stress Granules Closely Connected to the Viral Factories.	PLoS Pathog	2016 Oct 17	Nikolic J	doi: 10.1371/journal.ppat.1005942
18768985	Mutation of mapped TIA-1/TIAR binding sites in the 3' terminal stem-loop of West Nile virus minus-strand RNA in an infectious clone negatively affects genomic RNA amplification.	J Virol	2008 Nov	Emara MM	doi: 10.1128/JVI.00991-08
22855484	Hepatitis C virus (HCV) induces formation of stress granules whose proteins regulate HCV RNA replication and virus assembly and egress.	J Virol	2012 Oct	Garaigorta U	-
17599736	Effects of infliximab therapy on gene expression levels of tumor necrosis factor alpha, tristetraprolin, T cell intracellular antigen 1, and Hu antigen R in patients with rheumatoid arthritis.	Arthritis Rheum	2007 Jul	Sugihara M	-
14966131	An intronic polypyrimidine-rich element downstream of the donor site modulates cystic fibrosis transmembrane conductance regulator exon 9 alternative splicing.	J Biol Chem	2004 Apr 23	Zuccato E	-
18753794	Cellular protein TIA-1 regulates the expression of HBV surface antigen by binding the HBV posttranscriptional regulatory element.	Intervirology	2008	Tang H	doi: 10.1159/000151632
18439994	Large P body-like RNPs form in C. elegans oocytes in response to arrested ovulation, heat shock, osmotic stress, and anoxia and are regulated by the major sperm protein pathway.	Dev Biol	2008 Jun 1	Jud MC	doi: 10.1016/j.ydbio.2008.02.059
28298474	Tumor protein D52 expression is post-transcriptionally regulated by T-cell intercellular antigen (TIA) 1 and TIA-related protein via mRNA stability.	Biochem J	2017 May 4	Motohashi H	doi: 10.1042/BCJ20160942.
30641480	RNA granules associated with SAMD9-mediated poxvirus restriction are similar to antiviral granules in composition but do not require TIA1 for poxvirus restriction.	Virology	2019 Mar	Meng X	doi: 10.1016/j.virol.2019.01.007

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000474699	TIA1-209	686	-	-	- (aa)	-	-
ENST00000468787	TIA1-208	525	-	-	- (aa)	-	-
ENST00000474809	TIA1-210	915	-	ENSP00000430969	144 (aa)	-	E5RGV5
ENST00000482876	TIA1-214	562	-	-	- (aa)	-	-
ENST00000477044	TIA1-211	904	-	ENSP00000427794	161 (aa)	-	E5RG67
ENST00000484065	TIA1-215	350	-	-	- (aa)	-	-
ENST00000495774	TIA1-217	533	-	-	- (aa)	-	-
ENST00000481650	TIA1-213	549	-	-	- (aa)	-	-
ENST00000361692	TIA1-202	543	-	ENSP00000354838	152 (aa)	-	H7BY49
ENST00000445587	TIA1-206	1440	-	ENSP00000399567	285 (aa)	-	C9JTN7
ENST00000433529	TIA1-205	4647	XM_005264528	ENSP00000401371	386 (aa)	XP_005264585	P31483
ENST00000454815	TIA1-207	911	-	ENSP00000402263	114 (aa)	-	F8WE16
ENST00000497672	TIA1-220	346	-	-	- (aa)	-	-
ENST00000496452	TIA1-219	853	-	-	- (aa)	-	-
ENST00000282574	TIA1-201	3823	-	ENSP00000282574	385 (aa)	-	F8W8I6
ENST00000415783	TIA1-203	4633	XM_005264531	ENSP00000404023	375 (aa)	XP_005264588	P31483
ENST00000486392	TIA1-216	514	-	-	- (aa)	-	-
ENST00000416149	TIA1-204	821	-	ENSP00000413751	214 (aa)	-	P31483
ENST00000496096	TIA1-218	511	-	-	- (aa)	-	-
ENST00000477415	TIA1-212	510	-	-	- (aa)	-	-

Gene Model

Click here to download 's gene model file

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000116001	rs2706770	2	70244767	A	Low density lipoprotein cholesterol levels	29507422	unit decrease	0.024	EFO_0004611
ENSG00000116001	rs2706770	2	70244767	A	Total cholesterol levels	29507422	unit decrease	0.022	EFO_0004574
ENSG00000116001	rs2706770	2	70244767	A	Total cholesterol levels	29507422	unit decrease	0.025	EFO_0004574

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000116001's network

Paralog

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy
ENSG00000116001	TIA1	88	31.034	ENSG00000135316	SYNCRIP	54	32.143
ENSG00000116001	TIA1	88	40.741	ENSG00000099622	CIRBP	99	40.506
ENSG00000116001	TIA1	85	31.081	ENSG00000173933	RBM4	98	30.625
ENSG00000116001	TIA1	83	35.443	ENSG00000048740	CELF2	56	35.443
ENSG00000116001	TIA1	85	30.380	ENSG00000173914	RBM4B	97	30.380
ENSG00000116001	TIA1	97	30.201	ENSG00000174740	PABPC5	93	33.333
ENSG00000116001	TIA1	90	90.511	ENSG00000151923	TIAL1	100	89.394
ENSG00000116001	TIA1	86	36.667	ENSG00000244395	RBMY1D	79	38.462
ENSG00000116001	TIA1	88	37.956	ENSG00000143368	SF3B4	71	35.938
ENSG00000116001	TIA1	88	40.426	ENSG00000101104	PABPC1L	78	39.286
ENSG00000116001	TIA1	88	31.469	ENSG00000179950	PUF60	65	30.168
ENSG00000116001	TIA1	88	35.766	ENSG00000090621	PABPC4	94	34.314
ENSG00000116001	TIA1	63	34.783	ENSG00000076053	RBM7	74	31.868
ENSG00000116001	TIA1	86	36.667	ENSG00000242875	RBMY1B	79	38.462
ENSG00000116001	TIA1	89	44.000	ENSG00000159409	CELF3	74	37.805
ENSG00000116001	TIA1	88	38.182	ENSG00000138668	HNRNPD	53	35.593
ENSG00000116001	TIA1	88	31.343	ENSG00000115053	NCL	90	31.325
ENSG00000116001	TIA1	89	40.816	ENSG00000196361	ELAVL3	90	37.179
ENSG00000116001	TIA1	85	39.286	ENSG00000131051	RBM39	63	33.333
ENSG00000116001	TIA1	90	33.094	ENSG00000254535	PABPC4L	97	31.361
ENSG00000116001	TIA1	86	35.897	ENSG00000162374	ELAVL4	94	35.897
ENSG00000116001	TIA1	86	36.667	ENSG00000234414	RBMY1A1	79	38.462
ENSG00000116001	TIA1	88	32.593	ENSG00000066044	ELAVL1	93	30.488
ENSG00000116001	TIA1	69	41.333	ENSG00000102317	RBM3	54	36.905
ENSG00000116001	TIA1	72	35.366	ENSG00000265241	RBM8A	79	35.714
ENSG00000116001	TIA1	86	35.443	ENSG00000140488	CELF6	80	35.443
ENSG00000116001	TIA1	97	32.450	ENSG00000186288	PABPC1L2A	97	30.808
ENSG00000116001	TIA1	97	32.450	ENSG00000184388	PABPC1L2B	97	30.808
ENSG00000116001	TIA1	88	42.553	ENSG00000070756	PABPC1	99	35.577
ENSG00000116001	TIA1	87	35.802	ENSG00000161082	CELF5	51	33.333
ENSG00000116001	TIA1	57	31.579	ENSG00000147140	NONO	63	32.000
ENSG00000116001	TIA1	84	34.615	ENSG00000107105	ELAVL2	96	34.615
ENSG00000116001	TIA1	69	36.000	ENSG00000114503	NCBP2	74	31.373
ENSG00000116001	TIA1	88	37.226	ENSG00000151846	PABPC3	66	30.204
ENSG00000116001	TIA1	76	35.065	ENSG00000213516	RBMXL1	64	33.333
ENSG00000116001	TIA1	86	36.667	ENSG00000242389	RBMY1E	79	38.462
ENSG00000116001	TIA1	90	32.414	ENSG00000180098	TRNAU1AP	78	30.198

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy	Species
ENSG00000116001	TIA1	100	90.164	ENSAPOG00000001876	tia1	100	90.164	Acanthochromis_polyacanthus
ENSG00000116001	TIA1	100	82.041	ENSAPOG00000015534	tial1	100	70.918	Acanthochromis_polyacanthus
ENSG00000116001	TIA1	84	98.113	ENSAPOG00000007089	tia1l	93	80.588	Acanthochromis_polyacanthus
ENSG00000116001	TIA1	100	98.708	ENSAMEG00000016025	TIA1	100	98.708	Ailuropoda_melanoleuca
ENSG00000116001	TIA1	100	89.344	ENSACIG00000016352	tia1l	100	89.344	Amphilophus_citrinellus
ENSG00000116001	TIA1	100	79.297	ENSACIG00000003734	tial1	100	83.265	Amphilophus_citrinellus
ENSG00000116001	TIA1	98	91.304	ENSACIG00000014376	-	100	91.304	Amphilophus_citrinellus
ENSG00000116001	TIA1	100	90.164	ENSAOCG00000011133	-	100	91.787	Amphiprion_ocellaris
ENSG00000116001	TIA1	100	82.449	ENSAOCG00000004685	tial1	100	82.449	Amphiprion_ocellaris
ENSG00000116001	TIA1	100	88.571	ENSAOCG00000018765	tia1l	100	88.571	Amphiprion_ocellaris
ENSG00000116001	TIA1	100	90.164	ENSAPEG00000002524	-	100	90.164	Amphiprion_percula
ENSG00000116001	TIA1	100	82.449	ENSAPEG00000024742	tial1	100	82.449	Amphiprion_percula
ENSG00000116001	TIA1	100	88.571	ENSAPEG00000003200	tia1l	100	88.571	Amphiprion_percula
ENSG00000116001	TIA1	98	86.611	ENSATEG00000008865	tia1l	99	88.333	Anabas_testudineus
ENSG00000116001	TIA1	98	91.787	ENSATEG00000014593	-	100	91.787	Anabas_testudineus
ENSG00000116001	TIA1	100	82.857	ENSATEG00000012273	tial1	100	82.857	Anabas_testudineus
ENSG00000116001	TIA1	100	96.491	ENSAPLG00000009953	TIA1	99	94.517	Anas_platyrhynchos
ENSG00000116001	TIA1	100	100.000	ENSANAG00000026081	TIA1	100	100.000	Aotus_nancymaae
ENSG00000116001	TIA1	100	90.164	ENSACLG00000002317	-	99	90.164	Astatotilapia_calliptera
ENSG00000116001	TIA1	100	84.270	ENSACLG00000026467	tia1l	100	84.270	Astatotilapia_calliptera
ENSG00000116001	TIA1	97	86.861	ENSACLG00000020596	tial1	100	82.857	Astatotilapia_calliptera
ENSG00000116001	TIA1	100	81.746	ENSAMXG00000038511	tial1	100	81.746	Astyanax_mexicanus
ENSG00000116001	TIA1	100	81.443	ENSAMXG00000037884	tia1l	99	82.840	Astyanax_mexicanus
ENSG00000116001	TIA1	100	99.590	ENSBTAG00000019182	TIA1	100	99.590	Bos_taurus
ENSG00000116001	TIA1	100	100.000	ENSCJAG00000019278	TIA1	100	100.000	Callithrix_jacchus
ENSG00000116001	TIA1	100	99.123	ENSCAFG00000003341	TIA1	98	95.584	Canis_familiaris
ENSG00000116001	TIA1	100	99.590	ENSCAFG00020001832	TIA1	100	99.590	Canis_lupus_dingo
ENSG00000116001	TIA1	100	98.246	ENSCHIG00000020214	TIA1	99	99.574	Capra_hircus
ENSG00000116001	TIA1	100	100.000	ENSTSYG00000005276	TIA1	100	100.000	Carlito_syrichta
ENSG00000116001	TIA1	98	94.043	ENSCAPG00000017278	TIA1	100	94.043	Cavia_aperea
ENSG00000116001	TIA1	94	78.676	ENSCPOG00000006074	-	93	93.590	Cavia_porcellus
ENSG00000116001	TIA1	100	99.590	ENSCPOG00000008327	TIA1	100	99.590	Cavia_porcellus
ENSG00000116001	TIA1	100	99.123	ENSCCAG00000036430	TIA1	100	90.933	Cebus_capucinus
ENSG00000116001	TIA1	100	100.000	ENSCATG00000041446	TIA1	100	100.000	Cercocebus_atys
ENSG00000116001	TIA1	100	100.000	ENSCLAG00000009857	TIA1	100	100.000	Chinchilla_lanigera
ENSG00000116001	TIA1	100	100.000	ENSCSAG00000015135	TIA1	100	99.741	Chlorocebus_sabaeus
ENSG00000116001	TIA1	100	97.368	ENSCHOG00000003904	TIA1	100	80.570	Choloepus_hoffmanni
ENSG00000116001	TIA1	100	95.844	ENSCPBG00000003611	TIA1	100	95.844	Chrysemys_picta_bellii
ENSG00000116001	TIA1	100	100.000	ENSCANG00000031460	TIA1	100	100.000	Colobus_angolensis_palliatus
ENSG00000116001	TIA1	100	98.361	ENSCGRG00001013417	Tia1	100	98.361	Cricetulus_griseus_chok1gshd
ENSG00000116001	TIA1	100	98.361	ENSCGRG00000002902	Tia1	100	98.361	Cricetulus_griseus_crigri
ENSG00000116001	TIA1	100	80.408	ENSCSEG00000010695	tial1	100	80.408	Cynoglossus_semilaevis
ENSG00000116001	TIA1	100	85.714	ENSCSEG00000014331	tia1l	100	85.714	Cynoglossus_semilaevis
ENSG00000116001	TIA1	100	88.934	ENSCSEG00000014166	-	99	88.934	Cynoglossus_semilaevis
ENSG00000116001	TIA1	98	89.362	ENSCSEG00000010018	-	91	89.362	Cynoglossus_semilaevis
ENSG00000116001	TIA1	91	96.000	ENSCVAG00000006051	-	98	86.310	Cyprinodon_variegatus
ENSG00000116001	TIA1	91	89.855	ENSCVAG00000013609	tia1l	89	83.686	Cyprinodon_variegatus
ENSG00000116001	TIA1	100	80.816	ENSCVAG00000005689	tial1	100	80.816	Cyprinodon_variegatus
ENSG00000116001	TIA1	100	89.754	ENSCVAG00000015489	tia1	100	89.754	Cyprinodon_variegatus
ENSG00000116001	TIA1	100	79.381	ENSDARG00000026476	tia1l	99	80.531	Danio_rerio
ENSG00000116001	TIA1	91	93.478	ENSDARG00000052536	tia1	99	93.033	Danio_rerio
ENSG00000116001	TIA1	100	85.714	ENSDARG00000009525	tial1	100	85.714	Danio_rerio
ENSG00000116001	TIA1	100	98.246	ENSDNOG00000016356	TIA1	100	89.125	Dasypus_novemcinctus
ENSG00000116001	TIA1	100	100.000	ENSDORG00000008601	Tia1	100	91.257	Dipodomys_ordii
ENSG00000116001	TIA1	100	98.964	ENSETEG00000010021	TIA1	100	98.964	Echinops_telfairi
ENSG00000116001	TIA1	85	81.818	ENSEBUG00000001843	tia1l	99	58.824	Eptatretus_burgeri
ENSG00000116001	TIA1	100	99.123	ENSEASG00005007393	TIA1	100	98.705	Equus_asinus_asinus
ENSG00000116001	TIA1	100	99.123	ENSECAG00000022361	TIA1	100	98.705	Equus_caballus
ENSG00000116001	TIA1	100	97.368	ENSEEUG00000002964	TIA1	100	71.208	Erinaceus_europaeus
ENSG00000116001	TIA1	100	92.623	ENSELUG00000006377	tia1	99	92.623	Esox_lucius
ENSG00000116001	TIA1	100	92.623	ENSELUG00000005615	-	100	92.593	Esox_lucius
ENSG00000116001	TIA1	100	84.490	ENSELUG00000020994	tial1	100	84.490	Esox_lucius
ENSG00000116001	TIA1	100	99.590	ENSFCAG00000023732	TIA1	100	99.590	Felis_catus
ENSG00000116001	TIA1	91	99.275	ENSFALG00000008322	-	98	95.035	Ficedula_albicollis
ENSG00000116001	TIA1	98	88.293	ENSFALG00000002173	TIA1	100	88.293	Ficedula_albicollis
ENSG00000116001	TIA1	100	100.000	ENSFDAG00000014427	-	100	99.590	Fukomys_damarensis
ENSG00000116001	TIA1	92	75.188	ENSFDAG00000010316	-	94	88.288	Fukomys_damarensis
ENSG00000116001	TIA1	100	90.164	ENSFHEG00000006161	tia1	99	90.164	Fundulus_heteroclitus
ENSG00000116001	TIA1	100	88.163	ENSFHEG00000002832	tia1l	100	88.163	Fundulus_heteroclitus
ENSG00000116001	TIA1	90	83.212	ENSFHEG00000007703	tial1	100	80.000	Fundulus_heteroclitus
ENSG00000116001	TIA1	90	85.401	ENSGMOG00000005612	tial1	99	72.872	Gadus_morhua
ENSG00000116001	TIA1	91	87.681	ENSGMOG00000008423	tia1l	99	86.531	Gadus_morhua
ENSG00000116001	TIA1	91	91.339	ENSGMOG00000008843	tia1	99	85.404	Gadus_morhua
ENSG00000116001	TIA1	100	98.770	ENSGALG00000013879	TIA1	100	98.770	Gallus_gallus
ENSG00000116001	TIA1	100	74.126	ENSGAFG00000001124	tial1	100	74.126	Gambusia_affinis
ENSG00000116001	TIA1	100	90.164	ENSGAFG00000011317	-	100	90.164	Gambusia_affinis
ENSG00000116001	TIA1	90	88.321	ENSGACG00000003365	tial1	99	71.728	Gasterosteus_aculeatus
ENSG00000116001	TIA1	100	88.980	ENSGACG00000015800	tia1l	99	88.980	Gasterosteus_aculeatus
ENSG00000116001	TIA1	87	96.429	ENSGACG00000013294	-	99	86.957	Gasterosteus_aculeatus
ENSG00000116001	TIA1	100	98.770	ENSGAGG00000007529	TIA1	100	98.770	Gopherus_agassizii
ENSG00000116001	TIA1	100	99.123	ENSGGOG00000037511	TIA1	100	91.192	Gorilla_gorilla
ENSG00000116001	TIA1	100	82.857	ENSHBUG00000000813	tial1	100	82.857	Haplochromis_burtoni
ENSG00000116001	TIA1	100	90.164	ENSHBUG00000023154	-	100	91.787	Haplochromis_burtoni
ENSG00000116001	TIA1	100	88.980	ENSHBUG00000006676	tia1l	100	88.980	Haplochromis_burtoni
ENSG00000116001	TIA1	100	100.000	ENSHGLG00000005927	TIA1	100	99.590	Heterocephalus_glaber_female
ENSG00000116001	TIA1	100	100.000	ENSHGLG00100001107	TIA1	100	99.590	Heterocephalus_glaber_male
ENSG00000116001	TIA1	90	89.781	ENSHCOG00000004701	tial1	99	75.439	Hippocampus_comes
ENSG00000116001	TIA1	100	91.020	ENSHCOG00000005356	-	100	91.020	Hippocampus_comes
ENSG00000116001	TIA1	100	88.571	ENSHCOG00000005609	tia1l	100	88.571	Hippocampus_comes
ENSG00000116001	TIA1	100	81.961	ENSIPUG00000021261	tial1	100	81.961	Ictalurus_punctatus
ENSG00000116001	TIA1	99	80.829	ENSIPUG00000016702	tia1	99	82.111	Ictalurus_punctatus
ENSG00000116001	TIA1	100	100.000	ENSSTOG00000008309	TIA1	100	100.000	Ictidomys_tridecemlineatus
ENSG00000116001	TIA1	100	99.590	ENSJJAG00000017978	Tia1	100	99.590	Jaculus_jaculus
ENSG00000116001	TIA1	64	73.196	ENSJJAG00000020696	-	85	73.196	Jaculus_jaculus
ENSG00000116001	TIA1	92	61.481	ENSJJAG00000006909	-	94	68.421	Jaculus_jaculus
ENSG00000116001	TIA1	100	90.574	ENSKMAG00000008202	tia1	100	90.574	Kryptolebias_marmoratus
ENSG00000116001	TIA1	100	89.388	ENSKMAG00000011643	-	100	89.388	Kryptolebias_marmoratus
ENSG00000116001	TIA1	100	87.755	ENSLBEG00000023092	tia1l	100	81.022	Labrus_bergylta
ENSG00000116001	TIA1	97	85.401	ENSLBEG00000012865	tial1	100	81.633	Labrus_bergylta
ENSG00000116001	TIA1	100	90.574	ENSLBEG00000000122	-	99	90.574	Labrus_bergylta
ENSG00000116001	TIA1	100	91.228	ENSLACG00000017828	TIA1	98	89.764	Latimeria_chalumnae
ENSG00000116001	TIA1	100	95.492	ENSLOCG00000015324	tia1l	99	95.492	Lepisosteus_oculatus
ENSG00000116001	TIA1	99	81.154	ENSLOCG00000011405	tial1	88	81.154	Lepisosteus_oculatus
ENSG00000116001	TIA1	100	99.123	ENSLAFG00000003463	TIA1	100	98.964	Loxodonta_africana
ENSG00000116001	TIA1	100	100.000	ENSMFAG00000045951	TIA1	100	100.000	Macaca_fascicularis
ENSG00000116001	TIA1	100	100.000	ENSMMUG00000001126	TIA1	100	100.000	Macaca_mulatta
ENSG00000116001	TIA1	100	100.000	ENSMNEG00000030316	TIA1	100	100.000	Macaca_nemestrina
ENSG00000116001	TIA1	100	100.000	ENSMLEG00000044455	TIA1	100	100.000	Mandrillus_leucophaeus
ENSG00000116001	TIA1	100	90.984	ENSMAMG00000020566	-	99	90.984	Mastacembelus_armatus
ENSG00000116001	TIA1	100	90.535	ENSMAMG00000003680	tia1l	100	90.535	Mastacembelus_armatus
ENSG00000116001	TIA1	95	89.051	ENSMAMG00000013350	tial1	100	83.673	Mastacembelus_armatus
ENSG00000116001	TIA1	100	90.164	ENSMZEG00005001792	-	99	90.164	Maylandia_zebra
ENSG00000116001	TIA1	100	88.980	ENSMZEG00005006018	tia1l	100	88.980	Maylandia_zebra
ENSG00000116001	TIA1	97	86.861	ENSMZEG00005011289	tial1	100	82.857	Maylandia_zebra
ENSG00000116001	TIA1	98	98.723	ENSMGAG00000003493	TIA1	100	98.723	Meleagris_gallopavo
ENSG00000116001	TIA1	53	91.250	ENSMAUG00000008699	-	82	93.590	Mesocricetus_auratus
ENSG00000116001	TIA1	100	99.180	ENSMAUG00000020749	Tia1	100	99.180	Mesocricetus_auratus
ENSG00000116001	TIA1	100	100.000	ENSMICG00000002434	TIA1	100	100.000	Microcebus_murinus
ENSG00000116001	TIA1	91	83.333	ENSMOCG00000015245	-	97	71.467	Microtus_ochrogaster
ENSG00000116001	TIA1	100	99.590	ENSMOCG00000018898	-	100	99.590	Microtus_ochrogaster
ENSG00000116001	TIA1	100	84.411	ENSMMOG00000014966	-	100	84.411	Mola_mola
ENSG00000116001	TIA1	100	75.517	ENSMMOG00000008454	tial1	100	75.517	Mola_mola
ENSG00000116001	TIA1	91	86.232	ENSMMOG00000008453	tia1l	99	82.405	Mola_mola
ENSG00000116001	TIA1	100	98.246	ENSMODG00000011515	TIA1	100	96.891	Monodelphis_domestica
ENSG00000116001	TIA1	99	90.984	ENSMALG00000016924	-	99	90.984	Monopterus_albus
ENSG00000116001	TIA1	100	86.831	ENSMALG00000017478	tia1l	100	86.831	Monopterus_albus
ENSG00000116001	TIA1	100	99.180	MGP_CAROLIEiJ_G0028595	Tia1	100	99.180	Mus_caroli
ENSG00000116001	TIA1	100	99.180	ENSMUSG00000071337	Tia1	100	99.180	Mus_musculus
ENSG00000116001	TIA1	100	98.361	MGP_PahariEiJ_G0022332	Tia1	99	100.000	Mus_pahari
ENSG00000116001	TIA1	100	99.180	MGP_SPRETEiJ_G0029606	Tia1	100	99.180	Mus_spretus
ENSG00000116001	TIA1	100	99.123	ENSMPUG00000007196	TIA1	96	98.158	Mustela_putorius_furo
ENSG00000116001	TIA1	100	98.246	ENSMLUG00000011659	TIA1	100	95.619	Myotis_lucifugus
ENSG00000116001	TIA1	100	99.590	ENSNGAG00000011970	Tia1	100	99.590	Nannospalax_galili
ENSG00000116001	TIA1	97	86.861	ENSNBRG00000016849	tial1	100	82.857	Neolamprologus_brichardi
ENSG00000116001	TIA1	100	88.980	ENSNBRG00000011319	tia1l	100	88.980	Neolamprologus_brichardi
ENSG00000116001	TIA1	100	84.411	ENSNBRG00000010172	-	100	84.411	Neolamprologus_brichardi
ENSG00000116001	TIA1	100	100.000	ENSNLEG00000029145	TIA1	97	97.857	Nomascus_leucogenys
ENSG00000116001	TIA1	96	87.805	ENSMEUG00000013220	TIA1	99	75.401	Notamacropus_eugenii
ENSG00000116001	TIA1	88	97.619	ENSOPRG00000001066	TIA1	100	79.730	Ochotona_princeps
ENSG00000116001	TIA1	90	80.519	ENSOPRG00000016546	-	67	78.927	Ochotona_princeps
ENSG00000116001	TIA1	100	100.000	ENSODEG00000009409	TIA1	100	99.590	Octodon_degus
ENSG00000116001	TIA1	100	82.857	ENSONIG00000010290	tial1	100	82.857	Oreochromis_niloticus
ENSG00000116001	TIA1	100	88.980	ENSONIG00000007364	tia1l	100	88.980	Oreochromis_niloticus
ENSG00000116001	TIA1	100	90.164	ENSONIG00000015897	tia1	99	90.164	Oreochromis_niloticus
ENSG00000116001	TIA1	86	76.471	ENSOANG00000021170	-	100	76.471	Ornithorhynchus_anatinus
ENSG00000116001	TIA1	100	99.123	ENSOCUG00000011204	TIA1	100	98.964	Oryctolagus_cuniculus
ENSG00000116001	TIA1	100	81.224	ENSORLG00000013798	tial1	99	81.224	Oryzias_latipes
ENSG00000116001	TIA1	100	88.980	ENSORLG00000002529	-	100	88.980	Oryzias_latipes
ENSG00000116001	TIA1	100	90.164	ENSORLG00000015642	tia1	100	90.164	Oryzias_latipes
ENSG00000116001	TIA1	100	76.538	ENSORLG00020005291	tial1	100	76.538	Oryzias_latipes_hni
ENSG00000116001	TIA1	100	88.980	ENSORLG00020013161	tia1l	100	88.980	Oryzias_latipes_hni
ENSG00000116001	TIA1	100	90.164	ENSORLG00020021205	tia1	100	90.164	Oryzias_latipes_hni
ENSG00000116001	TIA1	100	88.980	ENSORLG00015020886	-	100	88.980	Oryzias_latipes_hsok
ENSG00000116001	TIA1	97	84.672	ENSORLG00015020318	tial1	100	81.224	Oryzias_latipes_hsok
ENSG00000116001	TIA1	100	90.164	ENSORLG00015011511	tia1	100	90.164	Oryzias_latipes_hsok
ENSG00000116001	TIA1	100	88.980	ENSOMEG00000016484	tia1l	100	88.980	Oryzias_melastigma
ENSG00000116001	TIA1	67	70.833	ENSOMEG00000000733	-	100	81.176	Oryzias_melastigma
ENSG00000116001	TIA1	100	90.164	ENSOMEG00000020931	tia1	100	91.304	Oryzias_melastigma
ENSG00000116001	TIA1	100	98.261	ENSOGAG00000010572	TIA1	100	89.770	Otolemur_garnettii
ENSG00000116001	TIA1	100	98.246	ENSOARG00000019709	TIA1	99	96.834	Ovis_aries
ENSG00000116001	TIA1	100	100.000	ENSPPAG00000041129	TIA1	100	100.000	Pan_paniscus
ENSG00000116001	TIA1	100	99.590	ENSPPRG00000012175	TIA1	100	99.590	Panthera_pardus
ENSG00000116001	TIA1	100	99.590	ENSPTIG00000011985	TIA1	100	99.590	Panthera_tigris_altaica
ENSG00000116001	TIA1	100	100.000	ENSPTRG00000023495	TIA1	100	100.000	Pan_troglodytes
ENSG00000116001	TIA1	100	100.000	ENSPANG00000025129	TIA1	100	100.000	Papio_anubis
ENSG00000116001	TIA1	67	90.625	ENSPKIG00000020731	-	97	90.625	Paramormyrops_kingsleyae
ENSG00000116001	TIA1	100	95.902	ENSPKIG00000017052	tia1l	99	95.902	Paramormyrops_kingsleyae
ENSG00000116001	TIA1	99	86.008	ENSPKIG00000005355	tial1	88	86.008	Paramormyrops_kingsleyae
ENSG00000116001	TIA1	99	81.298	ENSPSIG00000013690	-	100	81.298	Pelodiscus_sinensis
ENSG00000116001	TIA1	100	96.491	ENSPSIG00000013567	TIA1	100	95.902	Pelodiscus_sinensis
ENSG00000116001	TIA1	100	79.130	ENSPMGG00000023869	tia1l	100	67.553	Periophthalmus_magnuspinnatus
ENSG00000116001	TIA1	100	78.070	ENSPMGG00000017103	-	99	75.766	Periophthalmus_magnuspinnatus
ENSG00000116001	TIA1	100	84.362	ENSPMGG00000008999	tial1	100	84.362	Periophthalmus_magnuspinnatus
ENSG00000116001	TIA1	100	99.180	ENSPEMG00000001090	Tia1	100	99.180	Peromyscus_maniculatus_bairdii
ENSG00000116001	TIA1	93	87.640	ENSPMAG00000006529	tia1l	100	74.803	Petromyzon_marinus
ENSG00000116001	TIA1	100	98.246	ENSPCIG00000013084	TIA1	98	99.015	Phascolarctos_cinereus
ENSG00000116001	TIA1	100	89.754	ENSPFOG00000004539	-	99	89.754	Poecilia_formosa
ENSG00000116001	TIA1	90	83.212	ENSPFOG00000009767	tial1	100	67.519	Poecilia_formosa
ENSG00000116001	TIA1	100	88.571	ENSPFOG00000022243	tia1l	100	88.571	Poecilia_formosa
ENSG00000116001	TIA1	100	89.754	ENSPLAG00000013231	-	99	89.754	Poecilia_latipinna
ENSG00000116001	TIA1	100	89.712	ENSPLAG00000009390	tia1l	100	89.712	Poecilia_latipinna
ENSG00000116001	TIA1	97	83.212	ENSPLAG00000007718	tial1	100	73.427	Poecilia_latipinna
ENSG00000116001	TIA1	90	83.212	ENSPMEG00000006938	tial1	100	67.347	Poecilia_mexicana
ENSG00000116001	TIA1	100	89.754	ENSPMEG00000018062	-	100	89.754	Poecilia_mexicana
ENSG00000116001	TIA1	100	89.712	ENSPMEG00000013469	tia1l	100	89.712	Poecilia_mexicana
ENSG00000116001	TIA1	90	83.942	ENSPREG00000002689	tial1	100	68.974	Poecilia_reticulata
ENSG00000116001	TIA1	96	89.754	ENSPREG00000017346	tia1	90	89.754	Poecilia_reticulata
ENSG00000116001	TIA1	100	88.571	ENSPREG00000019232	tia1l	100	88.571	Poecilia_reticulata
ENSG00000116001	TIA1	100	100.000	ENSPPYG00000012326	TIA1	100	99.223	Pongo_abelii
ENSG00000116001	TIA1	100	98.246	ENSPCAG00000001859	TIA1	100	80.311	Procavia_capensis
ENSG00000116001	TIA1	100	100.000	ENSPCOG00000013271	TIA1	100	100.000	Propithecus_coquereli
ENSG00000116001	TIA1	100	99.123	ENSPVAG00000004846	TIA1	100	98.705	Pteropus_vampyrus
ENSG00000116001	TIA1	97	86.861	ENSPNYG00000003649	tial1	100	83.265	Pundamilia_nyererei
ENSG00000116001	TIA1	100	90.164	ENSPNYG00000008384	tia1	99	90.164	Pundamilia_nyererei
ENSG00000116001	TIA1	100	88.980	ENSPNYG00000006589	tia1l	100	88.980	Pundamilia_nyererei
ENSG00000116001	TIA1	100	85.306	ENSPNAG00000003272	tial1	100	85.306	Pygocentrus_nattereri
ENSG00000116001	TIA1	100	81.675	ENSPNAG00000016449	tia1l	99	82.493	Pygocentrus_nattereri
ENSG00000116001	TIA1	100	98.770	ENSRNOG00000016813	Tia1	100	98.770	Rattus_norvegicus
ENSG00000116001	TIA1	100	100.000	ENSRBIG00000030540	TIA1	100	100.000	Rhinopithecus_bieti
ENSG00000116001	TIA1	100	100.000	ENSRROG00000032699	TIA1	100	100.000	Rhinopithecus_roxellana
ENSG00000116001	TIA1	100	100.000	ENSSBOG00000034106	TIA1	100	100.000	Saimiri_boliviensis_boliviensis
ENSG00000116001	TIA1	100	98.246	ENSSHAG00000012544	TIA1	97	96.817	Sarcophilus_harrisii
ENSG00000116001	TIA1	97	89.781	ENSSFOG00015011413	tial1	99	85.597	Scleropages_formosus
ENSG00000116001	TIA1	100	95.082	ENSSFOG00015008776	tia1	100	95.082	Scleropages_formosus
ENSG00000116001	TIA1	100	92.181	ENSSFOG00015018496	-	99	92.181	Scleropages_formosus
ENSG00000116001	TIA1	100	88.066	ENSSMAG00000011347	tia1l	100	88.066	Scophthalmus_maximus
ENSG00000116001	TIA1	100	90.984	ENSSMAG00000020230	-	99	90.984	Scophthalmus_maximus
ENSG00000116001	TIA1	90	89.781	ENSSMAG00000012671	tial1	99	84.362	Scophthalmus_maximus
ENSG00000116001	TIA1	100	87.705	ENSSDUG00000023544	tia1l	100	89.388	Seriola_dumerili
ENSG00000116001	TIA1	100	91.393	ENSSDUG00000003453	-	99	91.393	Seriola_dumerili
ENSG00000116001	TIA1	100	84.898	ENSSDUG00000018021	tial1	100	84.898	Seriola_dumerili
ENSG00000116001	TIA1	100	91.393	ENSSLDG00000014625	-	99	91.393	Seriola_lalandi_dorsalis
ENSG00000116001	TIA1	100	84.898	ENSSLDG00000020001	tial1	100	84.898	Seriola_lalandi_dorsalis
ENSG00000116001	TIA1	100	87.705	ENSSLDG00000011450	tia1l	100	89.388	Seriola_lalandi_dorsalis
ENSG00000116001	TIA1	100	99.123	ENSSARG00000001997	TIA1	100	98.841	Sorex_araneus
ENSG00000116001	TIA1	100	98.770	ENSSPUG00000008547	TIA1	100	98.770	Sphenodon_punctatus
ENSG00000116001	TIA1	72	58.095	ENSSPAG00000002281	-	65	57.944	Stegastes_partitus
ENSG00000116001	TIA1	100	84.411	ENSSPAG00000004511	-	100	84.411	Stegastes_partitus
ENSG00000116001	TIA1	100	82.449	ENSSPAG00000000095	tial1	100	76.515	Stegastes_partitus
ENSG00000116001	TIA1	100	86.885	ENSSPAG00000008228	tia1l	100	88.571	Stegastes_partitus
ENSG00000116001	TIA1	100	99.590	ENSSSCG00000023409	TIA1	100	100.000	Sus_scrofa
ENSG00000116001	TIA1	92	93.401	ENSTGUG00000017307	TIA1	100	83.478	Taeniopygia_guttata
ENSG00000116001	TIA1	100	87.295	ENSTRUG00000005456	tia1l	100	88.980	Takifugu_rubripes
ENSG00000116001	TIA1	100	90.947	ENSTRUG00000015136	-	100	90.947	Takifugu_rubripes
ENSG00000116001	TIA1	100	87.698	ENSTNIG00000011433	-	100	87.698	Tetraodon_nigroviridis
ENSG00000116001	TIA1	100	83.529	ENSTNIG00000013470	tia1l	100	85.156	Tetraodon_nigroviridis
ENSG00000116001	TIA1	88	77.692	ENSTBEG00000008045	-	100	62.435	Tupaia_belangeri
ENSG00000116001	TIA1	92	100.000	ENSTBEG00000017228	TIA1	100	91.192	Tupaia_belangeri
ENSG00000116001	TIA1	100	98.246	ENSTTRG00000001195	TIA1	100	98.187	Tursiops_truncatus
ENSG00000116001	TIA1	100	99.590	ENSUAMG00000025833	TIA1	100	99.590	Ursus_americanus
ENSG00000116001	TIA1	100	99.590	ENSUMAG00000021459	TIA1	100	99.590	Ursus_maritimus
ENSG00000116001	TIA1	99	93.363	ENSVPAG00000007449	TIA1	100	89.378	Vicugna_pacos
ENSG00000116001	TIA1	100	99.123	ENSVVUG00000028040	TIA1	96	98.421	Vulpes_vulpes
ENSG00000116001	TIA1	100	88.235	ENSXETG00000008514	tia1	100	88.235	Xenopus_tropicalis
ENSG00000116001	TIA1	100	89.754	ENSXCOG00000008899	-	100	89.388	Xiphophorus_couchianus
ENSG00000116001	TIA1	100	84.411	ENSXCOG00000017733	tia1l	100	84.411	Xiphophorus_couchianus
ENSG00000116001	TIA1	90	79.310	ENSXCOG00000006063	tial1	100	69.610	Xiphophorus_couchianus
ENSG00000116001	TIA1	100	89.712	ENSXMAG00000018689	tia1l	100	89.712	Xiphophorus_maculatus
ENSG00000116001	TIA1	90	83.942	ENSXMAG00000027915	tial1	100	71.088	Xiphophorus_maculatus
ENSG00000116001	TIA1	100	89.754	ENSXMAG00000023528	-	100	89.754	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003723	RNA binding	22658674.22681889.	HDA	Function
GO:0005515	protein binding	7544399.12486009.	IPI	Function
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005737	cytoplasm	24965446.	IDA	Component
GO:0005829	cytosol	-	IDA	Component
GO:0006915	apoptotic process	-	IEA	Process
GO:0008143	poly(A) binding	1934064.	TAS	Function
GO:0008543	fibroblast growth factor receptor signaling pathway	-	TAS	Process
GO:0010494	cytoplasmic stress granule	21984414.	IDA	Component
GO:0010494	cytoplasmic stress granule	-	ISS	Component
GO:0017091	AU-rich element binding	-	IEA	Function
GO:0017148	negative regulation of translation	-	IEA	Process
GO:0042036	negative regulation of cytokine biosynthetic process	-	IEA	Process
GO:0048024	regulation of mRNA splicing, via spliceosome	11106748.	IDA	Process
GO:0097165	nuclear stress granule	21984414.	IDA	Component
GO:1903608	protein localization to cytoplasmic stress granule	24965446.	IMP	Process
GO:1904037	positive regulation of epithelial cell apoptotic process	-	IEA	Process

EuRBPDB

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Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBDs

RBPome

PRI

Literatures

Expression

Transcripts

Gene Model

GWAS

PPI

Paralog

Ortholog

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.