EuRBPDB

  • Home
  • Cancer
  • Family
  • Species
  • RBPredictor
  • Search
  • Download
  • Submit
  • Help
  • Contact
TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
28298474Tumor protein D52 expression is post-transcriptionally regulated by T-cell intercellular antigen (TIA) 1 and TIA-related protein via mRNA stability.Biochem J2017 May 4Motohashi Hdoi: 10.1042/BCJ20160942.
12949814Increased TIA-1 gene expression in the tumor microenvironment after locoregional administration of tumor necrosis factor-alpha to patients with soft tissue limb sarcoma.Int J Cancer2003 Nov 1Mocellin S-
28257633miR-19a promotes colorectal cancer proliferation and migration by targeting TIA1.Mol Cancer2017 Mar 4Liu Ydoi: 10.1186/s12943-017-0625-8.
29496454Potential use of TIA-1, MFF, microRNA-200a-3p, and microRNA-27 as a novel marker for hepatocellular carcinoma.Biochem Biophys Res Commun2018 Mar 18Tak Hdoi: 10.1016/j.bbrc.2018.02.189
21179245TIA-1 cytotoxic granule-associated RNA binding protein improves the prognostic performance of CD8 in mismatch repair-proficient colorectal cancer.PLoS One2010 Dec 10Zlobec Idoi: 10.1371/journal.pone.0014282.
25224594Alternative splicing of TIA-1 in human colon cancer regulates VEGF isoform expression, angiogenesis, tumour growth and bevacizumab resistance.Mol Oncol2015 JanHamdollah Zadeh MAdoi: 10.1016/j.molonc.2014.07.017
28174264Hippo signaling promotes JNK-dependent cell migration.Proc Natl Acad Sci U S A2017 Feb 21Ma Xdoi: 10.1073/pnas.1621359114

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
BLCAchr2702127133'UTRnovel0.15
BLCAchr270248421Missense_MutationnovelE4K0.39RRM_1
BRCAchr2702117533'UTRnovel0.2
BRCAchr270214463Missense_MutationnovelG307V0.19
BRCAchr270227814Missense_MutationNAH107Y0.29
BRCAchr270215394Missense_MutationNAD289H0.19
BRCAchr270212821Missense_MutationNAW353C0.4
BRCAchr270229103Intronnovel0.13
BRCAchr270229283Frame_Shift_InsnovelS86Rfs*110.03
BRCAchr270229285Nonsense_MutationnovelS86*0.02
CESCchr270227794SilentnovelL113L0.32
CESCchr2702116653'UTRnovel0.34
CESCchr270227734Splice_SiteNAX133_splice0.46
CHOLchr2702123173'UTRnovel0.28
COADchr270216919Nonsense_MutationnovelR184*0.13
COADchr270216750Intronnovel0.38
COADchr270236173Missense_MutationnovelY10C0.41RRM_1
COADchr270216907Missense_Mutationrs756853891A188T0.41
COADchr270216242Nonsense_MutationNAR244*0.44
ESCAchr270215471Missense_MutationnovelA263V0.38
ESCAchr2702121373'UTRnovel0.16
ESCAchr270216789Intronrs7494165250.14
GBMchr2702125023'UTRnovel0.59
GBMchr270248418Missense_MutationnovelM5V0.25RRM_1
GBMchr270216262Missense_MutationnovelF237C0.25
GBMchr270230819Frame_Shift_DelnovelH54Mfs*100.33
HNSCchr270224555Nonsense_MutationnovelW158*0.24
HNSCchr270216868Intronnovel0.15
KIRCchr270214406Missense_MutationNAG326A0.32
KIRPchr270229189Intronnovel0.5
LGGchr2702126573'UTRnovel0.06
LGGchr270227824Splice_SitenovelX104_splice0.38
LIHCchr270216747Intronnovel0.29
LIHCchr270229031Intronnovel0.08
LUADchr2702126333'UTRnovel0.07
LUADchr270224617SilentNAV137V0.15
LUADchr270216873Intronnovel0.03
LUADchr270227767SilentNAI122I0.14
LUADchr270230835Missense_Mutationrs370430518Y48C0.06RRM_1
LUSCchr270224557Missense_MutationnovelK157N0.15
LUSCchr270227750Missense_MutationnovelP128L0.18
LUSCchr270230788Missense_MutationNAA64P0.24
LUSCchr270236138Missense_MutationnovelL22V0.15RRM_1
LUSCchr270224603Missense_Mutationrs372738231A142V0.35
LUSCchr270214394Missense_MutationNAP330L0.29
LUSCchr270216241Missense_Mutationrs777224522R244Q0.48
LUSCchr270229220Intronnovel0.15
LUSCchr270229290Missense_MutationNAP84R0.06
OVchr270229001Intronnovel0.13
OVchr270216808Intronrs7763829110.03
PRADchr270212744Missense_Mutationrs774014016R379Q0.21
PRADchr270236148SilentnovelV18V0.31
READchr270216855IntronNA0.48
READchr270216209Missense_MutationNAR255W0.46
SARCchr270216807Intronrs7707808840.82
SARCchr270214485Frame_Shift_DelnovelI300Lfs*890.89
SKCMchr270214413Missense_MutationnovelP324S0.22
SKCMchr270229291Missense_MutationnovelP84S0.2
SKCMchr270216908Silentrs533863358P187P0.22
SKCMchr270229162Intronnovel0.31
SKCMchr270224563Frame_Shift_InsnovelN156Qfs*60.41
SKCMchr270230837SilentNAP47P0.41
SKCMchr270229012Intronnovel0.16
SKCMchr270224622Nonsense_MutationNAR136*0.33
SKCMchr270229130Intronnovel0.2
SKCMchr270216432Nonsense_MutationnovelY217*0.1
SKCMchr2702126873'UTRnovel0.18
SKCMchr270227735Missense_Mutationrs375191972S133L0.63
SKCMchr270227815Silentrs770120862F106F0.4
STADchr270227735Missense_Mutationrs375191972S133L0.37
STADchr270214370Missense_MutationNAA338V0.33
STADchr270214419Missense_MutationNAY322H0.24
STADchr270216882Splice_Regionnovel0.36
STADchr270227759Missense_MutationNAA125V0.22
STADchr2702127143'UTRnovel0.18
STADchr270216936Missense_MutationnovelR178K0.06
STADchr270216854Intronnovel0.21
STADchr2702125343'UTRnovel0.28
STADchr270227734Splice_SiteNAX133_splice0.29
UCECchr270215419SilentnovelK280K0.38
UCECchr270227735Nonsense_MutationnovelS133*0.1
UCECchr270236168Missense_MutationNAG12S0.22RRM_1
UCECchr2702127093'UTRnovel0.12
UCECchr270216205Splice_Regionnovel0.39
UCECchr270229254Intronnovel0.46
UCECchr270230814Missense_MutationnovelE55G0.3
UCECchr270216965SilentNAG168G0.33
UCECchr270248411Missense_MutationnovelK7T0.5RRM_1
UCECchr2702116743'UTRnovel0.35
UCECchr270216281Missense_Mutationrs752346516R231C0.4
UCECchr2702122443'UTRnovel0.29
UCECchr2702124363'UTRnovel0.44
UCECchr270216746Intronnovel0.36
UCECchr270230808Missense_Mutationrs778629190R57H0.37
UCECchr270229201Intronnovel0.4
UCECchr2702484445'UTRnovel0.45
UCECchr2702125453'UTRnovel0.5
UCECchr2702484965'UTRnovel0.23
UCECchr270229083Missense_MutationNAV96I0.33
UCECchr2702120103'UTRnovel0.35
UCECchr2702126773'UTRnovel0.22
UCECchr270228988Intronnovel0.43
UCECchr2702122333'UTRnovel0.09
UCECchr270236091Missense_MutationNAK37N0.23RRM_1
UCECchr270216909Missense_MutationnovelP187H0.12
UCECchr270229199Intronnovel0.1
UCECchr2702484975'UTRnovel0.29
UCECchr2702116963'UTRnovel0.5
UCECchr2702121953'UTRnovel0.46
UCECchr2702122353'UTRnovel0.15
UCECchr270229085Missense_MutationnovelT95I0.38
UCSchr270214360Missense_MutationnovelQ341H0.4

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
KIRPDEL0.02780.08832
PAADDEL0.04890.2014
READDEL0.06670.19022

Survival Analysis
CancerP-value Q-value
THYM0.0019

Kaplan-Meier Survival Analysis

KIRC0.0001

Kaplan-Meier Survival Analysis

SARC0.03

Kaplan-Meier Survival Analysis

ACC0.00011

Kaplan-Meier Survival Analysis

HNSC0.0014

Kaplan-Meier Survival Analysis

SKCM0.00024

Kaplan-Meier Survival Analysis

PRAD0.038

Kaplan-Meier Survival Analysis

BLCA0.0001

Kaplan-Meier Survival Analysis

LAML0.0082

Kaplan-Meier Survival Analysis

GBM0.0013

Kaplan-Meier Survival Analysis

LIHC0.0047

Kaplan-Meier Survival Analysis

LGG0.0045

Kaplan-Meier Survival Analysis

LUAD0.0086

Kaplan-Meier Survival Analysis

UVM0.014

Kaplan-Meier Survival Analysis

Drugs

Select Dataset :


Input Drug :


Input Cell Line :


Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBDs
  • RBPome
  • PRI
  • Literatures
  • Expression
  • Transcripts
  • Gene Model
  • GWAS
  • PPI
  • Paralogs
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000116001 (Gene tree)
Gene ID
7072
Gene Symbol
TIA1
Alias
N
Full Name
TIA1 cytotoxic granule associated RNA binding protein
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Minus strand
Length
39,264 bases
Position
chr2:70,209,444-70,248,707
Accession
11802
RBP type
canonical RBP
Summary
The product encoded by this gene is a member of a RNA-binding protein family and possesses nucleolytic activity against cytotoxic lymphocyte (CTL) target cells. It has been suggested that this protein may be involved in the induction of apoptosis as it preferentially recognizes poly(A) homopolymers and induces DNA fragmentation in CTL targets. The major granule-associated species is a 15-kDa protein that is thought to be derived from the carboxyl terminus of the 40-kDa product by proteolytic processing. Alternative splicing resulting in different isoforms has been found for this gene. [provided by RefSeq, May 2017]
RNA binding domains(RBDs)
Protein IDDomain Pfam IDE-value Domain number Total number
ENSP00000404023RRM_1PF00076.222.5e-6713
ENSP00000404023RRM_1PF00076.222.5e-6723
ENSP00000404023RRM_1PF00076.222.5e-6733
ENSP00000282574RRM_1PF00076.222.8e-6713
ENSP00000282574RRM_1PF00076.222.8e-6723
ENSP00000282574RRM_1PF00076.222.8e-6733
ENSP00000401371RRM_1PF00076.222.8e-6713
ENSP00000401371RRM_1PF00076.222.8e-6723
ENSP00000401371RRM_1PF00076.222.8e-6733
ENSP00000399567RRM_1PF00076.224.7e-5813
ENSP00000399567RRM_1PF00076.224.7e-5823
ENSP00000399567RRM_1PF00076.224.7e-5833
ENSP00000413751RRM_1PF00076.227e-4812
ENSP00000413751RRM_1PF00076.227e-4822
ENSP00000354838RRM_1PF00076.221e-3912
ENSP00000354838RRM_1PF00076.221e-3922
ENSP00000402263RRM_1PF00076.223.2e-1311
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
22681889The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts4SURIC & HEK2932012 MayBaltz AGDOI: 10.1016/j.molcel.2012.05.021
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & HEK2932019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & HEK2932018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
29431736Capturing the interactome of newly transcribed RNAPolyT-RICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
29431736Capturing the interactome of newly transcribed RNARIC & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
29431736Capturing the interactome of newly transcribed RNARICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
22658674Insights into RNA biology from an atlas of mammalian mRNA-binding proteinsRIC & Hela2012 May 31Castello ADOI: 10.1016/j.cell.2012.04.031
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & Hela2018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & MCF10A2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & MCF72018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & U2OS2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
27453046Comprehensive Identification of RNA-Binding Domains in Human CellsRIC & Hela2016 Aug 18Castello ADOI: 10.1016/j.molcel.2016.06.029
30352994Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome captureRIC & Jurkat2018 Oct 23Perez-Perri JIDOI:10.1038/s41467-018-06557-8
Protein-RNA interaction(RNA-Binding Site)
Click here to download all RNA binding sites
Click here to download all RNA binding sites

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
28980860 behavior of proteins involved in amyotrophic lateral sclerosis and frontotemporal lobar degeneration.Autophagy2017Uversky VNdoi: 10.1080/15548627.2017.1384889
22115364Alternative splicing of the neurofibromatosis typeI pre-mRNA.Biosci Rep2012 Apr 1Barron VAdoi: 10.1042/BSR20110060.
10613902RNA-binding proteins TIA-1 and TIAR link the phosphorylation of eIF-2 alpha to the assembly of mammalian stress granules.J Cell Biol1999 Dec 27Kedersha NL-
19605462NMR solution structure of HP0827 (O25501_HELPY) from Helicobacter pylori: model of the possible RNA-binding site.J Biochem2009 NovJang SBdoi: 10.1093/jb/mvp105
22175897Revising the historical collection of epithelioid cell-rich lymphomas of the Kiel Lymph Node Registry: what is Lennert's lymphoma nowadays?Histopathology2011 DecHartmann Sdoi: 10.1111/j.1365-2559.2011.04069.x.
25108040Pathological stress granules in Alzheimer's disease.Brain Res2014 Oct 10Ash PEdoi: 10.1016/j.brainres.2014.05.052
30126736Subcutaneous panniculitis-like T-cell lymphoma: Clinical features, therapeutic approach, and outcome in a case series of 16 patients.J Am Acad Dermatol2018 NovLopez-Lerma Idoi: 10.1016/j.jaad.2018.05.1243
12885872Regulation of cyclooxygenase-2 expression by the translational silencer TIA-1.J Exp Med2003 Aug 4Dixon DA-
18562690JunD represses transcription and translation of the tight junction protein zona occludens-1 modulating intestinal epithelial barrier function.Mol Biol Cell2008 SepChen Jdoi: 10.1091/mbc.E08-02-0175
22619362Frequent gain and loss of intronic splicing regulatory elements during the evolution of vertebrates.Genome Biol Evol2012Voelker RBdoi: 10.1093/gbe/evs051
30367664Formation of Toxic Oligomeric Assemblies of RNA-binding Protein: Musashi in Alzheimer's disease.Acta Neuropathol Commun2018 Oct 26Sengupta Udoi: 10.1186/s40478-018-0615-0.
8871565Structure, tissue distribution and genomic organization of the murine RRM-type RNA binding proteins TIA-1 and TIAR.Nucleic Acids Res1996 Oct 1Beck AR-
8570616Characterization of GMP-17, a granule membrane protein that moves to the plasma membrane of natural killer cells following target cell recognition.Proc Natl Acad Sci U S A1996 Jan 23Medley QG-
8576255Individual RNA recognition motifs of TIA-1 and TIAR have different RNA binding specificities.J Biol Chem1996 Feb 2Dember LM-
16527256Identification of FUSE-binding proteins as interacting partners of TIA proteins.Biochem Biophys Res Commun2006 Apr 28Rothe F-
12414941Cell proteins TIA-1 and TIAR interact with the 3' stem-loop of the West Nile virus complementary minus-strand RNA and facilitate virus replication.J Virol2002 DecLi W-
16278295Identification of the sequence determinants mediating the nucleo-cytoplasmic shuttling of TIAR and TIA-1 RNA-binding proteins.J Cell Sci2005 Dec 1Zhang T-
14662769Identification of RNA-binding proteins in RAW 264.7 cells that recognize a lipopolysaccharide-responsive element in the 3-untranslated region of the murine cyclooxygenase-2 mRNA.J Biol Chem2004 Feb 27Cok SJ-
19709424Depletion of T-cell intracellular antigen proteins promotes cell proliferation.Genome Biol2009Reyes Rdoi: 10.1186/gb-2009-10-8-r87
18490444MKP-1 mRNA stabilization and translational control by RNA-binding proteins HuR and NF90.Mol Cell Biol2008 JulKuwano Ydoi: 10.1128/MCB.00165-08
17488725Two isoforms of the T-cell intracellular antigen 1 (TIA-1) splicing factor display distinct splicing regulation activities. Control of TIA-1 isoform ratio by TIA-1-related protein.J Biol Chem2007 Jul 6Izquierdo JM-
20596534Impaired embryonic development in mice overexpressing the RNA-binding protein TIAR.PLoS One2010 Jun 28Kharraz Ydoi: 10.1371/journal.pone.0011352.
20477871The splicing factor ASF/SF2 is associated with TIA-1-related/TIA-1-containing ribonucleoproteic complexes and contributes to post-transcriptional repression of gene expression.FEBS J2010 JunDelestienne Ndoi: 10.1111/j.1742-4658.2010.07664.x
24824036The binding of TIA-1 to RNA C-rich sequences is driven by its C-terminal RRM domain.RNA Biol2014Cruz-Gallardo I-
24682828Structure, dynamics and RNA binding of the multi-domain splicing factor TIA-1.Nucleic Acids Res2014 MayWang Idoi: 10.1093/nar/gku193
23902765RNA binding of T-cell intracellular antigen-1 (TIA-1) C-terminal RNA recognition motif is modified by pH conditions.J Biol Chem2013 Sep 6Cruz-Gallardo Idoi: 10.1074/jbc.M113.489070
26981431Genome-wide analysis of TIAR RNA ligands in mouse macrophages before and after LPS stimulation.Genom Data2016 Feb 8Kharraz Ydoi: 10.1016/j.gdata.2016.02.007
28904350Tia1 dependent regulation of mRNA subcellular location and translation controls p53 expression in B cells.Nat Commun2017 Sep 13Diaz-Munoz MDdoi: 10.1038/s41467-017-00454-2.
1934064A polyadenylate binding protein localized to the granules of cytolytic lymphocytes induces DNA fragmentation in target cells.Cell1991 Nov 1Tian Q-
11121440Dynamic shuttling of TIA-1 accompanies the recruitment of mRNA to mammalian stress granules.J Cell Biol2000 Dec 11Kedersha N-
16775137Dendritic localization of the translational repressor Pumilio 2 and its contribution to dendritic stress granules.J Neurosci2006 Jun 14Vessey JP-
18927617Hepatic transcriptome analysis of hepatitis C virus infection in chimpanzees defines unique gene expression patterns associated with viral clearance.PLoS One2008Nanda Sdoi: 10.1371/journal.pone.0003442
18005751Inhibition of cytoplasmic mRNA stress granule formation by a viral proteinase.Cell Host Microbe2007 Nov 15White JP-
21654213Alternative splicing in spinal muscular atrophy underscores the role of an intron definition model.RNA Biol2011 Jul-AugSingh NNdoi: 10.4161/rna.8.4.16224
30327138Transcriptome meta-analysis identifies immune signature comprising of RNA binding proteins in ulcerative colitis patients.Cell Immunol2018 DecNaz Sdoi: 10.1016/j.cellimm.2018.09.003
7533298The RNA-binding protein TIAR is translocated from the nucleus to the cytoplasm during Fas-mediated apoptotic cell death.Proc Natl Acad Sci U S A1995 Feb 28Taupin JL-
7544399Fas-activated serine/threonine kinase (FAST) phosphorylates TIA-1 during Fas-mediated apoptosis.J Exp Med1995 Sep 1Tian Q-
7512092Expression of perforin, granzyme A and TIA-1 by human uterine CD56+ NK cells implies they are activated and capable of effector functions.Hum Reprod1993 DecKing A-
1326761Identification and functional characterization of a TIA-1-related nucleolysin.Proc Natl Acad Sci U S A1992 Sep 15Kawakami A-
8759725Expression of the CTL-associated protein TIA-1 during murine embryogenesis.J Immunol1996 Aug 15Lowin B-
8396236The developmentally-regulated Drosophila gene rox8 encodes an RRM-type RNA binding protein structurally related to human TIA-1-type nucleolysins.Nucleic Acids Res1993 Aug 11Brand S-
8176212Intron-exon organization and chromosomal localization of the human TIA-1 gene.J Immunol1994 May 15Kawakami A-
7890163Novel Drosophila melanogaster genes encoding RRM-type RNA-binding proteins identified by a degenerate PCR strategy.Gene1995 Mar 10Brand SF-
16581801Translational control of cytochrome c by RNA-binding proteins TIA-1 and HuR.Mol Cell Biol2006 AprKawai T-
12949814Increased TIA-1 gene expression in the tumor microenvironment after locoregional administration of tumor necrosis factor-alpha to patients with soft tissue limb sarcoma.Int J Cancer2003 Nov 1Mocellin S-
12533540TIA-1 or TIAR is required for DT40 cell viability.J Biol Chem2003 Mar 21Le Guiner C-
12440953AU-rich element-mediated translational control: complexity and multiple activities of trans-activating factors.Biochem Soc Trans2002 NovZhang T-
12380690Visibly stressed: the role of eIF2, TIA-1, and stress granules in protein translation.Cell Stress Chaperones2002 AprAnderson P-
12140254Stressful initiations.J Cell Sci2002 Aug 15Anderson P-
11809833Evidence that ternary complex (eIF2-GTP-tRNA(i)(Met))-deficient preinitiation complexes are core constituents of mammalian stress granules.Mol Biol Cell2002 JanKedersha N-
11359930Accumulation of mutant huntingtin fragments in aggresome-like inclusion bodies as a result of insufficient protein degradation.Mol Biol Cell2001 MayWaelter S-
10936786Intra-tumoral cytolytic cells: pattern of distribution in B-cell non Hodgkin s lymphoma.Pathol Oncol Res2000Perambakam S-
10938105The RNA-binding protein TIA-1 is a novel mammalian splicing regulator acting through intron sequences adjacent to a 5' splice site.Mol Cell Biol2000 SepDel Gatto-Konczak F-
16890199Control of the ATP synthase beta subunit expression by RNA-binding proteins TIA-1, TIAR, and HuR.Biochem Biophys Res Commun2006 Sep 22Izquierdo JM-
16221671Mammalian Smaug is a translational repressor that forms cytoplasmic foci similar to stress granules.J Biol Chem2005 Dec 30Baez MV-
16227602Identification and functional outcome of mRNAs associated with RNA-binding protein TIA-1.Mol Cell Biol2005 NovLopez de Silanes I-
15371533Stress granule assembly is mediated by prion-like aggregation of TIA-1.Mol Biol Cell2004 DecGilks N-
14597390De novo gene expression and antisense inhibition in cultured cells of BmTRN-1, cloned from the midgut of the silkworm, Bombyx mori, which is homologous with mammalian TIA-1/R.Gene2003 Nov 27Kotani E-
23401021Welander distal myopathy is caused by a mutation in the RNA-binding protein TIA1.Ann Neurol2013 AprHackman Pdoi: 10.1002/ana.23831
23077311Induction of stress granule-like structures in vesicular stomatitis virus-infected cells.J Virol2013 JanDinh PXdoi: 10.1128/JVI.02305-12
19819975Characterization of conserved tandem donor sites and intronic motifs required for alternative splicing in corticosteroid receptor genes.Endocrinology2009 NovRivers Cdoi: 10.1210/en.2009-0346
19386911Cross-seeding fibrillation of Q/N-rich proteins offers new pathomechanism of polyglutamine diseases.J Neurosci2009 Apr 22Furukawa Ydoi: 10.1523/JNEUROSCI.0783-09.2009.
19318808Primary cutaneous peripheral T-cell lymphoma with aberrant coexpression of CD20: case report and review of the literature.Am J Dermatopathol2009 AprBalmer NNdoi: 10.1097/DAD.0b013e31818cc039.
19270389Molecular characterization of a TIA-1-like RNA-binding protein in cells derived from the fall armyworm Spodoptera frugiperda (Lepidoptera: Noctuidae).Biosci Biotechnol Biochem2009 Mar 23Muto S-
18456862A systematic analysis of intronic sequences downstream of 5' splice sites reveals a widespread role for U-rich motifs and TIA1/TIAL1 proteins in alternative splicing regulation.Genome Res2008 AugAznarez Idoi: 10.1101/gr.073155.107
17580305Nuclear protein TIA-1 regulates COL2A1 alternative splicing and interacts with precursor mRNA and genomic DNA.J Biol Chem2007 Aug 17McAlinden A-
17466948The RNA-binding protein PTB exerts translational control on 3'-untranslated region of the mRNA for the ATP synthase beta-subunit.Biochem Biophys Res Commun2007 Jun 15Reyes R-
17209421[Stress granules: RNP-containing cytoplasmic bodies springing up under stress. The structure and mechanism of organization].Mol Biol (Mosk)2006 Nov-DecIvanov PA-
17074806Apigenin prevents UVB-induced cyclooxygenase 2 expression: coupled mRNA stabilization and translational inhibition.Mol Cell Biol2007 JanTong X-
22154808Three RNA recognition motifs participate in RNA recognition and structural organization by the pro-apoptotic factor TIA-1.J Mol Biol2012 Jan 27Bauer WJdoi: 10.1016/j.jmb.2011.11.040
21957303Poliovirus unlinks TIA1 aggregation and mRNA stress granule formation.J Virol2011 DecWhite JPdoi: 10.1128/JVI.05888-11
21846467A structural insight into the C-terminal RNA recognition motifs of T-cell intracellular antigen-1 protein.FEBS Lett2011 Oct 3Aroca Adoi: 10.1016/j.febslet.2011.07.037
21347286RNA binding protein CUGBP2/CELF2 mediates curcumin-induced mitotic catastrophe of pancreatic cancer cells.PLoS One2011 Feb 11Subramaniam Ddoi: 10.1371/journal.pone.0016958.
21261285Large favorable enthalpy changes drive specific RNA recognition by RNA recognition motif proteins.Biochemistry2011 Mar 8McLaughlin KJdoi: 10.1021/bi102057m
21179245TIA-1 cytotoxic granule-associated RNA binding protein improves the prognostic performance of CD8 in mismatch repair-proficient colorectal cancer.PLoS One2010 Dec 10Zlobec Idoi: 10.1371/journal.pone.0014282.
23213403Wnt signalling antagonizes stress granule assembly through a Dishevelled-dependent mechanism.Biol Open2012 Feb 15Sahoo PKdoi: 10.1242/bio.2011023
20453113mRNA escape from stress granule sequestration is dictated by localization to the endoplasmic reticulum.FASEB J2010 SepUnsworth Hdoi: 10.1096/fj.09-151142
25519906Post-transcriptional regulation of programmed cell death 4 (PDCD4) mRNA by the RNA-binding proteins human antigen R (HuR) and T-cell intracellular antigen 1 (TIA1).J Biol Chem2015 Feb 6Wigington CPdoi: 10.1074/jbc.M114.631937
25461769TIA1 interacts with annexin A7 in regulating vascular endothelial cell autophagy.Int J Biochem Cell Biol2014 DecHuang Sdoi: 10.1016/j.biocel.2014.10.015
25013173Free mRNA in excess upon polysome dissociation is a scaffold for protein multimerization to form stress granules.Nucleic Acids Res2014 JulBounedjah Odoi: 10.1093/nar/gku582
24879147Identification of a novel MTOR activator and discovery of a competing endogenous RNA regulating autophagy in vascular endothelial cells.Autophagy2014 JunGe Ddoi: 10.4161/auto.28363.
27160897Interaction of tau with the RNA-Binding Protein TIA1 Regulates tau Pathophysiology and Toxicity.Cell Rep2016 May 17Vanderweyde Tdoi: 10.1016/j.celrep.2016.04.045
24696465The stress granule component TIA-1 binds tick-borne encephalitis virus RNA and is recruited to perinuclear sites of viral replication to inhibit viral translation.J Virol2014 JunAlbornoz Adoi: 10.1128/JVI.03736-13
24627160Oxygen sufficiency controls TOP mRNA translation via the TSC-Rheb-mTOR pathway in a 4E-BP-independent manner.J Mol Cell Biol2014 JunMiloslavski Rdoi: 10.1093/jmcb/mju008
24590458The involvement of mRNA processing factors TIA-1, TIAR, and PABP-1 during mammalian hibernation.Cell Stress Chaperones2014 NovTessier SNdoi: 10.1007/s12192-014-0505-8
24566137HuR and TIA1/TIAL1 are involved in regulation of alternative splicing of SIRT1 pre-mRNA.Int J Mol Sci2014 Feb 20Zhao Wdoi: 10.3390/ijms15022946.
27371730Long Noncoding RNA MALAT1 Promotes Aggressive Pancreatic Cancer Proliferation and Metastasis via the Stimulation of Autophagy.Mol Cancer Ther2016 SepLi Ldoi: 10.1158/1535-7163.MCT-16-0008
28221306Whole Exome Sequencing Identifies Atypical Welander Distal Myopathy in Patient.J Clin Neuromuscul Dis2017 MarGass Jdoi: 10.1097/CND.0000000000000164.
26958940Tumor-promoting function and prognostic significance of the RNA-binding protein T-cell intracellular antigen-1 in esophageal squamous cell carcinoma.Oncotarget2016 Mar 29Hamada Jdoi: 10.18632/oncotarget.7937.
26865701The Stress Granule RNA-Binding Protein TIAR-1 Protects Female Germ Cells from Heat Shock in Caenorhabditis elegans.G3 (Bethesda)2016 Apr 7Huelgas-Morales Gdoi: 10.1534/g3.115.026815.
25797890Active immunosurveillance in the tumor microenvironment of colorectal cancer is associated with low frequency tumor budding and improved outcome.Transl Res2015 AugKoelzer VHdoi: 10.1016/j.trsl.2015.02.008
29273772Reducing the RNA binding protein TIA1 protects against tau-mediated neurodegeneration in vivo.Nat Neurosci2018 JanApicco DJdoi: 10.1038/s41593-017-0022-z
29298433TIA-1 Self-Multimerization, Phase Separation, and Recruitment into Stress Granules Are Dynamically Regulated by Zn2.Cell Rep2018 Jan 2Rayman JBdoi: 10.1016/j.celrep.2017.12.036.
29337236Maintenance of the Innate Seizure Threshold by Cyclooxygenase-2 is Not Influenced by the Translational Silencer, T-cell Intracellular Antigen-1.Neuroscience2018 Mar 1Gong Ydoi: 10.1016/j.neuroscience.2018.01.004
29370934Mutation analysis of the TIA1 gene in Chinese patients with amyotrophic lateral sclerosis and frontotemporal dementia.Neurobiol Aging2018 AprYuan Zdoi: 10.1016/j.neurobiolaging.2017.12.017
29429924The TIA1 RNA-Binding Protein Family Regulates EIF2AK2-Mediated Stress Response and Cell Cycle Progression.Mol Cell2018 Feb 15Meyer Cdoi: 10.1016/j.molcel.2018.01.011.
29621237Amino acid starvation sensing dampens IL-1β production by activating riboclustering and autophagy.PLoS Biol2018 Apr 5Battu Sdoi: 10.1371/journal.pbio.2005317
29891946Cellular stress alters 3'UTR landscape through alternative polyadenylation and isoform-specific degradation.Nat Commun2018 Jun 11Zheng Ddoi: 10.1038/s41467-018-04730-7.
30157547RNA-Binding Proteins in Amyotrophic Lateral Sclerosis.Mol Cells2018 Sep 30Zhao Mdoi: 10.14348/molcells.2018.0243
30348840A Heterologous Cell Model for Studying the Role of T-Cell Intracellular Antigen 1 in Welander Distal Myopathy.Mol Cell Biol2018 Dec 11Carrascoso Idoi: 10.1128/MCB.00299-18
30533021Transcriptome-wide analysis links the short-term expression of the b isoforms of TIA proteins to protective proteostasis-mediated cell quiescence response.PLoS One2018 Dec 11Carrascoso Idoi: 10.1371/journal.pone.0208526
30865887Genetic Perturbation of TIA1 Reveals a Physiological Role in Fear Memory.Cell Rep2019 Mar 12Rayman JBdoi: 10.1016/j.celrep.2019.02.048.
31138677New roles for the de-ubiquitylating enzyme OTUD4 in an RNA-protein network and RNA granules.J Cell Sci2019 Jun 17Das Rdoi: 10.1242/jcs.229252.
31332267USP10 is a critical factor for Tau-positive stress granule formation in neuronal cells.Sci Rep2019 Jul 22Piatnitskaia Sdoi: 10.1038/s41598-019-47033-7.
27749929Rabies Virus Infection Induces the Formation of Stress Granules Closely Connected to the Viral Factories.PLoS Pathog2016 Oct 17Nikolic Jdoi: 10.1371/journal.ppat.1005942
18768985Mutation of mapped TIA-1/TIAR binding sites in the 3' terminal stem-loop of West Nile virus minus-strand RNA in an infectious clone negatively affects genomic RNA amplification.J Virol2008 NovEmara MMdoi: 10.1128/JVI.00991-08
22855484Hepatitis C virus (HCV) induces formation of stress granules whose proteins regulate HCV RNA replication and virus assembly and egress.J Virol2012 OctGaraigorta U-
17599736Effects of infliximab therapy on gene expression levels of tumor necrosis factor alpha, tristetraprolin, T cell intracellular antigen 1, and Hu antigen R in patients with rheumatoid arthritis.Arthritis Rheum2007 JulSugihara M-
14966131An intronic polypyrimidine-rich element downstream of the donor site modulates cystic fibrosis transmembrane conductance regulator exon 9 alternative splicing.J Biol Chem2004 Apr 23Zuccato E-
18753794Cellular protein TIA-1 regulates the expression of HBV surface antigen by binding the HBV posttranscriptional regulatory element.Intervirology2008Tang Hdoi: 10.1159/000151632
18439994Large P body-like RNPs form in C. elegans oocytes in response to arrested ovulation, heat shock, osmotic stress, and anoxia and are regulated by the major sperm protein pathway.Dev Biol2008 Jun 1Jud MCdoi: 10.1016/j.ydbio.2008.02.059
28298474Tumor protein D52 expression is post-transcriptionally regulated by T-cell intercellular antigen (TIA) 1 and TIA-related protein via mRNA stability.Biochem J2017 May 4Motohashi Hdoi: 10.1042/BCJ20160942.
30641480RNA granules associated with SAMD9-mediated poxvirus restriction are similar to antiviral granules in composition but do not require TIA1 for poxvirus restriction.Virology2019 MarMeng Xdoi: 10.1016/j.virol.2019.01.007
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000474699TIA1-209686--- (aa)--
ENST00000468787TIA1-208525--- (aa)--
ENST00000474809TIA1-210915-ENSP00000430969144 (aa)-E5RGV5
ENST00000482876TIA1-214562--- (aa)--
ENST00000477044TIA1-211904-ENSP00000427794161 (aa)-E5RG67
ENST00000484065TIA1-215350--- (aa)--
ENST00000495774TIA1-217533--- (aa)--
ENST00000481650TIA1-213549--- (aa)--
ENST00000361692TIA1-202543-ENSP00000354838152 (aa)-H7BY49
ENST00000445587TIA1-2061440-ENSP00000399567285 (aa)-C9JTN7
ENST00000433529TIA1-2054647XM_005264528ENSP00000401371386 (aa)XP_005264585P31483
ENST00000454815TIA1-207911-ENSP00000402263114 (aa)-F8WE16
ENST00000497672TIA1-220346--- (aa)--
ENST00000496452TIA1-219853--- (aa)--
ENST00000282574TIA1-2013823-ENSP00000282574385 (aa)-F8W8I6
ENST00000415783TIA1-2034633XM_005264531ENSP00000404023375 (aa)XP_005264588P31483
ENST00000486392TIA1-216514--- (aa)--
ENST00000416149TIA1-204821-ENSP00000413751214 (aa)-P31483
ENST00000496096TIA1-218511--- (aa)--
ENST00000477415TIA1-212510--- (aa)--
Gene Model
Click here to download ENSG00000116001's gene model file
GWAS
ensgIDSNPChromosomePositionSNP-risk TraitPubmedID95% CIOr or BEAT EFO ID
ENSG00000116001rs2706770270244767ALow density lipoprotein cholesterol levels29507422unit decrease0.024EFO_0004611
ENSG00000116001rs2706770270244767ATotal cholesterol levels29507422unit decrease0.022EFO_0004574
ENSG00000116001rs2706770270244767ATotal cholesterol levels29507422unit decrease0.025EFO_0004574
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000116001's network

* RBP PPI network refers to all genes directly bind to RBP
Paralogs
Ensembl IDGene SymbolCoverageIdentiy ParalogGene SymbolCoverageIdentiy
ENSG00000116001TIA18831.034ENSG00000135316SYNCRIP5432.143
ENSG00000116001TIA18840.741ENSG00000099622CIRBP9940.506
ENSG00000116001TIA18531.081ENSG00000173933RBM49830.625
ENSG00000116001TIA18335.443ENSG00000048740CELF25635.443
ENSG00000116001TIA18530.380ENSG00000173914RBM4B9730.380
ENSG00000116001TIA19730.201ENSG00000174740PABPC59333.333
ENSG00000116001TIA19090.511ENSG00000151923TIAL110089.394
ENSG00000116001TIA18636.667ENSG00000244395RBMY1D7938.462
ENSG00000116001TIA18837.956ENSG00000143368SF3B47135.938
ENSG00000116001TIA18840.426ENSG00000101104PABPC1L7839.286
ENSG00000116001TIA18831.469ENSG00000179950PUF606530.168
ENSG00000116001TIA18835.766ENSG00000090621PABPC49434.314
ENSG00000116001TIA16334.783ENSG00000076053RBM77431.868
ENSG00000116001TIA18636.667ENSG00000242875RBMY1B7938.462
ENSG00000116001TIA18944.000ENSG00000159409CELF37437.805
ENSG00000116001TIA18838.182ENSG00000138668HNRNPD5335.593
ENSG00000116001TIA18831.343ENSG00000115053NCL9031.325
ENSG00000116001TIA18940.816ENSG00000196361ELAVL39037.179
ENSG00000116001TIA18539.286ENSG00000131051RBM396333.333
ENSG00000116001TIA19033.094ENSG00000254535PABPC4L9731.361
ENSG00000116001TIA18635.897ENSG00000162374ELAVL49435.897
ENSG00000116001TIA18636.667ENSG00000234414RBMY1A17938.462
ENSG00000116001TIA18832.593ENSG00000066044ELAVL19330.488
ENSG00000116001TIA16941.333ENSG00000102317RBM35436.905
ENSG00000116001TIA17235.366ENSG00000265241RBM8A7935.714
ENSG00000116001TIA18635.443ENSG00000140488CELF68035.443
ENSG00000116001TIA19732.450ENSG00000186288PABPC1L2A9730.808
ENSG00000116001TIA19732.450ENSG00000184388PABPC1L2B9730.808
ENSG00000116001TIA18842.553ENSG00000070756PABPC19935.577
ENSG00000116001TIA18735.802ENSG00000161082CELF55133.333
ENSG00000116001TIA15731.579ENSG00000147140NONO6332.000
ENSG00000116001TIA18434.615ENSG00000107105ELAVL29634.615
ENSG00000116001TIA16936.000ENSG00000114503NCBP27431.373
ENSG00000116001TIA18837.226ENSG00000151846PABPC36630.204
ENSG00000116001TIA17635.065ENSG00000213516RBMXL16433.333
ENSG00000116001TIA18636.667ENSG00000242389RBMY1E7938.462
ENSG00000116001TIA19032.414ENSG00000180098TRNAU1AP7830.198
Orthologs
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000116001TIA110090.164ENSAPOG00000001876tia110090.164Acanthochromis_polyacanthus
ENSG00000116001TIA110082.041ENSAPOG00000015534tial110070.918Acanthochromis_polyacanthus
ENSG00000116001TIA18498.113ENSAPOG00000007089tia1l9380.588Acanthochromis_polyacanthus
ENSG00000116001TIA110098.708ENSAMEG00000016025TIA110098.708Ailuropoda_melanoleuca
ENSG00000116001TIA110089.344ENSACIG00000016352tia1l10089.344Amphilophus_citrinellus
ENSG00000116001TIA110079.297ENSACIG00000003734tial110083.265Amphilophus_citrinellus
ENSG00000116001TIA19891.304ENSACIG00000014376-10091.304Amphilophus_citrinellus
ENSG00000116001TIA110090.164ENSAOCG00000011133-10091.787Amphiprion_ocellaris
ENSG00000116001TIA110082.449ENSAOCG00000004685tial110082.449Amphiprion_ocellaris
ENSG00000116001TIA110088.571ENSAOCG00000018765tia1l10088.571Amphiprion_ocellaris
ENSG00000116001TIA110090.164ENSAPEG00000002524-10090.164Amphiprion_percula
ENSG00000116001TIA110082.449ENSAPEG00000024742tial110082.449Amphiprion_percula
ENSG00000116001TIA110088.571ENSAPEG00000003200tia1l10088.571Amphiprion_percula
ENSG00000116001TIA19886.611ENSATEG00000008865tia1l9988.333Anabas_testudineus
ENSG00000116001TIA19891.787ENSATEG00000014593-10091.787Anabas_testudineus
ENSG00000116001TIA110082.857ENSATEG00000012273tial110082.857Anabas_testudineus
ENSG00000116001TIA110096.491ENSAPLG00000009953TIA19994.517Anas_platyrhynchos
ENSG00000116001TIA1100100.000ENSANAG00000026081TIA1100100.000Aotus_nancymaae
ENSG00000116001TIA110090.164ENSACLG00000002317-9990.164Astatotilapia_calliptera
ENSG00000116001TIA110084.270ENSACLG00000026467tia1l10084.270Astatotilapia_calliptera
ENSG00000116001TIA19786.861ENSACLG00000020596tial110082.857Astatotilapia_calliptera
ENSG00000116001TIA110081.746ENSAMXG00000038511tial110081.746Astyanax_mexicanus
ENSG00000116001TIA110081.443ENSAMXG00000037884tia1l9982.840Astyanax_mexicanus
ENSG00000116001TIA110099.590ENSBTAG00000019182TIA110099.590Bos_taurus
ENSG00000116001TIA1100100.000ENSCJAG00000019278TIA1100100.000Callithrix_jacchus
ENSG00000116001TIA110099.123ENSCAFG00000003341TIA19895.584Canis_familiaris
ENSG00000116001TIA110099.590ENSCAFG00020001832TIA110099.590Canis_lupus_dingo
ENSG00000116001TIA110098.246ENSCHIG00000020214TIA19999.574Capra_hircus
ENSG00000116001TIA1100100.000ENSTSYG00000005276TIA1100100.000Carlito_syrichta
ENSG00000116001TIA19894.043ENSCAPG00000017278TIA110094.043Cavia_aperea
ENSG00000116001TIA19478.676ENSCPOG00000006074-9393.590Cavia_porcellus
ENSG00000116001TIA110099.590ENSCPOG00000008327TIA110099.590Cavia_porcellus
ENSG00000116001TIA110099.123ENSCCAG00000036430TIA110090.933Cebus_capucinus
ENSG00000116001TIA1100100.000ENSCATG00000041446TIA1100100.000Cercocebus_atys
ENSG00000116001TIA1100100.000ENSCLAG00000009857TIA1100100.000Chinchilla_lanigera
ENSG00000116001TIA1100100.000ENSCSAG00000015135TIA110099.741Chlorocebus_sabaeus
ENSG00000116001TIA110097.368ENSCHOG00000003904TIA110080.570Choloepus_hoffmanni
ENSG00000116001TIA110095.844ENSCPBG00000003611TIA110095.844Chrysemys_picta_bellii
ENSG00000116001TIA1100100.000ENSCANG00000031460TIA1100100.000Colobus_angolensis_palliatus
ENSG00000116001TIA110098.361ENSCGRG00001013417Tia110098.361Cricetulus_griseus_chok1gshd
ENSG00000116001TIA110098.361ENSCGRG00000002902Tia110098.361Cricetulus_griseus_crigri
ENSG00000116001TIA110080.408ENSCSEG00000010695tial110080.408Cynoglossus_semilaevis
ENSG00000116001TIA110085.714ENSCSEG00000014331tia1l10085.714Cynoglossus_semilaevis
ENSG00000116001TIA110088.934ENSCSEG00000014166-9988.934Cynoglossus_semilaevis
ENSG00000116001TIA19889.362ENSCSEG00000010018-9189.362Cynoglossus_semilaevis
ENSG00000116001TIA19196.000ENSCVAG00000006051-9886.310Cyprinodon_variegatus
ENSG00000116001TIA19189.855ENSCVAG00000013609tia1l8983.686Cyprinodon_variegatus
ENSG00000116001TIA110080.816ENSCVAG00000005689tial110080.816Cyprinodon_variegatus
ENSG00000116001TIA110089.754ENSCVAG00000015489tia110089.754Cyprinodon_variegatus
ENSG00000116001TIA110079.381ENSDARG00000026476tia1l9980.531Danio_rerio
ENSG00000116001TIA19193.478ENSDARG00000052536tia19993.033Danio_rerio
ENSG00000116001TIA110085.714ENSDARG00000009525tial110085.714Danio_rerio
ENSG00000116001TIA110098.246ENSDNOG00000016356TIA110089.125Dasypus_novemcinctus
ENSG00000116001TIA1100100.000ENSDORG00000008601Tia110091.257Dipodomys_ordii
ENSG00000116001TIA110098.964ENSETEG00000010021TIA110098.964Echinops_telfairi
ENSG00000116001TIA18581.818ENSEBUG00000001843tia1l9958.824Eptatretus_burgeri
ENSG00000116001TIA110099.123ENSEASG00005007393TIA110098.705Equus_asinus_asinus
ENSG00000116001TIA110099.123ENSECAG00000022361TIA110098.705Equus_caballus
ENSG00000116001TIA110097.368ENSEEUG00000002964TIA110071.208Erinaceus_europaeus
ENSG00000116001TIA110092.623ENSELUG00000006377tia19992.623Esox_lucius
ENSG00000116001TIA110092.623ENSELUG00000005615-10092.593Esox_lucius
ENSG00000116001TIA110084.490ENSELUG00000020994tial110084.490Esox_lucius
ENSG00000116001TIA110099.590ENSFCAG00000023732TIA110099.590Felis_catus
ENSG00000116001TIA19199.275ENSFALG00000008322-9895.035Ficedula_albicollis
ENSG00000116001TIA19888.293ENSFALG00000002173TIA110088.293Ficedula_albicollis
ENSG00000116001TIA1100100.000ENSFDAG00000014427-10099.590Fukomys_damarensis
ENSG00000116001TIA19275.188ENSFDAG00000010316-9488.288Fukomys_damarensis
ENSG00000116001TIA110090.164ENSFHEG00000006161tia19990.164Fundulus_heteroclitus
ENSG00000116001TIA110088.163ENSFHEG00000002832tia1l10088.163Fundulus_heteroclitus
ENSG00000116001TIA19083.212ENSFHEG00000007703tial110080.000Fundulus_heteroclitus
ENSG00000116001TIA19085.401ENSGMOG00000005612tial19972.872Gadus_morhua
ENSG00000116001TIA19187.681ENSGMOG00000008423tia1l9986.531Gadus_morhua
ENSG00000116001TIA19191.339ENSGMOG00000008843tia19985.404Gadus_morhua
ENSG00000116001TIA110098.770ENSGALG00000013879TIA110098.770Gallus_gallus
ENSG00000116001TIA110074.126ENSGAFG00000001124tial110074.126Gambusia_affinis
ENSG00000116001TIA110090.164ENSGAFG00000011317-10090.164Gambusia_affinis
ENSG00000116001TIA19088.321ENSGACG00000003365tial19971.728Gasterosteus_aculeatus
ENSG00000116001TIA110088.980ENSGACG00000015800tia1l9988.980Gasterosteus_aculeatus
ENSG00000116001TIA18796.429ENSGACG00000013294-9986.957Gasterosteus_aculeatus
ENSG00000116001TIA110098.770ENSGAGG00000007529TIA110098.770Gopherus_agassizii
ENSG00000116001TIA110099.123ENSGGOG00000037511TIA110091.192Gorilla_gorilla
ENSG00000116001TIA110082.857ENSHBUG00000000813tial110082.857Haplochromis_burtoni
ENSG00000116001TIA110090.164ENSHBUG00000023154-10091.787Haplochromis_burtoni
ENSG00000116001TIA110088.980ENSHBUG00000006676tia1l10088.980Haplochromis_burtoni
ENSG00000116001TIA1100100.000ENSHGLG00000005927TIA110099.590Heterocephalus_glaber_female
ENSG00000116001TIA1100100.000ENSHGLG00100001107TIA110099.590Heterocephalus_glaber_male
ENSG00000116001TIA19089.781ENSHCOG00000004701tial19975.439Hippocampus_comes
ENSG00000116001TIA110091.020ENSHCOG00000005356-10091.020Hippocampus_comes
ENSG00000116001TIA110088.571ENSHCOG00000005609tia1l10088.571Hippocampus_comes
ENSG00000116001TIA110081.961ENSIPUG00000021261tial110081.961Ictalurus_punctatus
ENSG00000116001TIA19980.829ENSIPUG00000016702tia19982.111Ictalurus_punctatus
ENSG00000116001TIA1100100.000ENSSTOG00000008309TIA1100100.000Ictidomys_tridecemlineatus
ENSG00000116001TIA110099.590ENSJJAG00000017978Tia110099.590Jaculus_jaculus
ENSG00000116001TIA16473.196ENSJJAG00000020696-8573.196Jaculus_jaculus
ENSG00000116001TIA19261.481ENSJJAG00000006909-9468.421Jaculus_jaculus
ENSG00000116001TIA110090.574ENSKMAG00000008202tia110090.574Kryptolebias_marmoratus
ENSG00000116001TIA110089.388ENSKMAG00000011643-10089.388Kryptolebias_marmoratus
ENSG00000116001TIA110087.755ENSLBEG00000023092tia1l10081.022Labrus_bergylta
ENSG00000116001TIA19785.401ENSLBEG00000012865tial110081.633Labrus_bergylta
ENSG00000116001TIA110090.574ENSLBEG00000000122-9990.574Labrus_bergylta
ENSG00000116001TIA110091.228ENSLACG00000017828TIA19889.764Latimeria_chalumnae
ENSG00000116001TIA110095.492ENSLOCG00000015324tia1l9995.492Lepisosteus_oculatus
ENSG00000116001TIA19981.154ENSLOCG00000011405tial18881.154Lepisosteus_oculatus
ENSG00000116001TIA110099.123ENSLAFG00000003463TIA110098.964Loxodonta_africana
ENSG00000116001TIA1100100.000ENSMFAG00000045951TIA1100100.000Macaca_fascicularis
ENSG00000116001TIA1100100.000ENSMMUG00000001126TIA1100100.000Macaca_mulatta
ENSG00000116001TIA1100100.000ENSMNEG00000030316TIA1100100.000Macaca_nemestrina
ENSG00000116001TIA1100100.000ENSMLEG00000044455TIA1100100.000Mandrillus_leucophaeus
ENSG00000116001TIA110090.984ENSMAMG00000020566-9990.984Mastacembelus_armatus
ENSG00000116001TIA110090.535ENSMAMG00000003680tia1l10090.535Mastacembelus_armatus
ENSG00000116001TIA19589.051ENSMAMG00000013350tial110083.673Mastacembelus_armatus
ENSG00000116001TIA110090.164ENSMZEG00005001792-9990.164Maylandia_zebra
ENSG00000116001TIA110088.980ENSMZEG00005006018tia1l10088.980Maylandia_zebra
ENSG00000116001TIA19786.861ENSMZEG00005011289tial110082.857Maylandia_zebra
ENSG00000116001TIA19898.723ENSMGAG00000003493TIA110098.723Meleagris_gallopavo
ENSG00000116001TIA15391.250ENSMAUG00000008699-8293.590Mesocricetus_auratus
ENSG00000116001TIA110099.180ENSMAUG00000020749Tia110099.180Mesocricetus_auratus
ENSG00000116001TIA1100100.000ENSMICG00000002434TIA1100100.000Microcebus_murinus
ENSG00000116001TIA19183.333ENSMOCG00000015245-9771.467Microtus_ochrogaster
ENSG00000116001TIA110099.590ENSMOCG00000018898-10099.590Microtus_ochrogaster
ENSG00000116001TIA110084.411ENSMMOG00000014966-10084.411Mola_mola
ENSG00000116001TIA110075.517ENSMMOG00000008454tial110075.517Mola_mola
ENSG00000116001TIA19186.232ENSMMOG00000008453tia1l9982.405Mola_mola
ENSG00000116001TIA110098.246ENSMODG00000011515TIA110096.891Monodelphis_domestica
ENSG00000116001TIA19990.984ENSMALG00000016924-9990.984Monopterus_albus
ENSG00000116001TIA110086.831ENSMALG00000017478tia1l10086.831Monopterus_albus
ENSG00000116001TIA110099.180MGP_CAROLIEiJ_G0028595Tia110099.180Mus_caroli
ENSG00000116001TIA110099.180ENSMUSG00000071337Tia110099.180Mus_musculus
ENSG00000116001TIA110098.361MGP_PahariEiJ_G0022332Tia199100.000Mus_pahari
ENSG00000116001TIA110099.180MGP_SPRETEiJ_G0029606Tia110099.180Mus_spretus
ENSG00000116001TIA110099.123ENSMPUG00000007196TIA19698.158Mustela_putorius_furo
ENSG00000116001TIA110098.246ENSMLUG00000011659TIA110095.619Myotis_lucifugus
ENSG00000116001TIA110099.590ENSNGAG00000011970Tia110099.590Nannospalax_galili
ENSG00000116001TIA19786.861ENSNBRG00000016849tial110082.857Neolamprologus_brichardi
ENSG00000116001TIA110088.980ENSNBRG00000011319tia1l10088.980Neolamprologus_brichardi
ENSG00000116001TIA110084.411ENSNBRG00000010172-10084.411Neolamprologus_brichardi
ENSG00000116001TIA1100100.000ENSNLEG00000029145TIA19797.857Nomascus_leucogenys
ENSG00000116001TIA19687.805ENSMEUG00000013220TIA19975.401Notamacropus_eugenii
ENSG00000116001TIA18897.619ENSOPRG00000001066TIA110079.730Ochotona_princeps
ENSG00000116001TIA19080.519ENSOPRG00000016546-6778.927Ochotona_princeps
ENSG00000116001TIA1100100.000ENSODEG00000009409TIA110099.590Octodon_degus
ENSG00000116001TIA110082.857ENSONIG00000010290tial110082.857Oreochromis_niloticus
ENSG00000116001TIA110088.980ENSONIG00000007364tia1l10088.980Oreochromis_niloticus
ENSG00000116001TIA110090.164ENSONIG00000015897tia19990.164Oreochromis_niloticus
ENSG00000116001TIA18676.471ENSOANG00000021170-10076.471Ornithorhynchus_anatinus
ENSG00000116001TIA110099.123ENSOCUG00000011204TIA110098.964Oryctolagus_cuniculus
ENSG00000116001TIA110081.224ENSORLG00000013798tial19981.224Oryzias_latipes
ENSG00000116001TIA110088.980ENSORLG00000002529-10088.980Oryzias_latipes
ENSG00000116001TIA110090.164ENSORLG00000015642tia110090.164Oryzias_latipes
ENSG00000116001TIA110076.538ENSORLG00020005291tial110076.538Oryzias_latipes_hni
ENSG00000116001TIA110088.980ENSORLG00020013161tia1l10088.980Oryzias_latipes_hni
ENSG00000116001TIA110090.164ENSORLG00020021205tia110090.164Oryzias_latipes_hni
ENSG00000116001TIA110088.980ENSORLG00015020886-10088.980Oryzias_latipes_hsok
ENSG00000116001TIA19784.672ENSORLG00015020318tial110081.224Oryzias_latipes_hsok
ENSG00000116001TIA110090.164ENSORLG00015011511tia110090.164Oryzias_latipes_hsok
ENSG00000116001TIA110088.980ENSOMEG00000016484tia1l10088.980Oryzias_melastigma
ENSG00000116001TIA16770.833ENSOMEG00000000733-10081.176Oryzias_melastigma
ENSG00000116001TIA110090.164ENSOMEG00000020931tia110091.304Oryzias_melastigma
ENSG00000116001TIA110098.261ENSOGAG00000010572TIA110089.770Otolemur_garnettii
ENSG00000116001TIA110098.246ENSOARG00000019709TIA19996.834Ovis_aries
ENSG00000116001TIA1100100.000ENSPPAG00000041129TIA1100100.000Pan_paniscus
ENSG00000116001TIA110099.590ENSPPRG00000012175TIA110099.590Panthera_pardus
ENSG00000116001TIA110099.590ENSPTIG00000011985TIA110099.590Panthera_tigris_altaica
ENSG00000116001TIA1100100.000ENSPTRG00000023495TIA1100100.000Pan_troglodytes
ENSG00000116001TIA1100100.000ENSPANG00000025129TIA1100100.000Papio_anubis
ENSG00000116001TIA16790.625ENSPKIG00000020731-9790.625Paramormyrops_kingsleyae
ENSG00000116001TIA110095.902ENSPKIG00000017052tia1l9995.902Paramormyrops_kingsleyae
ENSG00000116001TIA19986.008ENSPKIG00000005355tial18886.008Paramormyrops_kingsleyae
ENSG00000116001TIA19981.298ENSPSIG00000013690-10081.298Pelodiscus_sinensis
ENSG00000116001TIA110096.491ENSPSIG00000013567TIA110095.902Pelodiscus_sinensis
ENSG00000116001TIA110079.130ENSPMGG00000023869tia1l10067.553Periophthalmus_magnuspinnatus
ENSG00000116001TIA110078.070ENSPMGG00000017103-9975.766Periophthalmus_magnuspinnatus
ENSG00000116001TIA110084.362ENSPMGG00000008999tial110084.362Periophthalmus_magnuspinnatus
ENSG00000116001TIA110099.180ENSPEMG00000001090Tia110099.180Peromyscus_maniculatus_bairdii
ENSG00000116001TIA19387.640ENSPMAG00000006529tia1l10074.803Petromyzon_marinus
ENSG00000116001TIA110098.246ENSPCIG00000013084TIA19899.015Phascolarctos_cinereus
ENSG00000116001TIA110089.754ENSPFOG00000004539-9989.754Poecilia_formosa
ENSG00000116001TIA19083.212ENSPFOG00000009767tial110067.519Poecilia_formosa
ENSG00000116001TIA110088.571ENSPFOG00000022243tia1l10088.571Poecilia_formosa
ENSG00000116001TIA110089.754ENSPLAG00000013231-9989.754Poecilia_latipinna
ENSG00000116001TIA110089.712ENSPLAG00000009390tia1l10089.712Poecilia_latipinna
ENSG00000116001TIA19783.212ENSPLAG00000007718tial110073.427Poecilia_latipinna
ENSG00000116001TIA19083.212ENSPMEG00000006938tial110067.347Poecilia_mexicana
ENSG00000116001TIA110089.754ENSPMEG00000018062-10089.754Poecilia_mexicana
ENSG00000116001TIA110089.712ENSPMEG00000013469tia1l10089.712Poecilia_mexicana
ENSG00000116001TIA19083.942ENSPREG00000002689tial110068.974Poecilia_reticulata
ENSG00000116001TIA19689.754ENSPREG00000017346tia19089.754Poecilia_reticulata
ENSG00000116001TIA110088.571ENSPREG00000019232tia1l10088.571Poecilia_reticulata
ENSG00000116001TIA1100100.000ENSPPYG00000012326TIA110099.223Pongo_abelii
ENSG00000116001TIA110098.246ENSPCAG00000001859TIA110080.311Procavia_capensis
ENSG00000116001TIA1100100.000ENSPCOG00000013271TIA1100100.000Propithecus_coquereli
ENSG00000116001TIA110099.123ENSPVAG00000004846TIA110098.705Pteropus_vampyrus
ENSG00000116001TIA19786.861ENSPNYG00000003649tial110083.265Pundamilia_nyererei
ENSG00000116001TIA110090.164ENSPNYG00000008384tia19990.164Pundamilia_nyererei
ENSG00000116001TIA110088.980ENSPNYG00000006589tia1l10088.980Pundamilia_nyererei
ENSG00000116001TIA110085.306ENSPNAG00000003272tial110085.306Pygocentrus_nattereri
ENSG00000116001TIA110081.675ENSPNAG00000016449tia1l9982.493Pygocentrus_nattereri
ENSG00000116001TIA110098.770ENSRNOG00000016813Tia110098.770Rattus_norvegicus
ENSG00000116001TIA1100100.000ENSRBIG00000030540TIA1100100.000Rhinopithecus_bieti
ENSG00000116001TIA1100100.000ENSRROG00000032699TIA1100100.000Rhinopithecus_roxellana
ENSG00000116001TIA1100100.000ENSSBOG00000034106TIA1100100.000Saimiri_boliviensis_boliviensis
ENSG00000116001TIA110098.246ENSSHAG00000012544TIA19796.817Sarcophilus_harrisii
ENSG00000116001TIA19789.781ENSSFOG00015011413tial19985.597Scleropages_formosus
ENSG00000116001TIA110095.082ENSSFOG00015008776tia110095.082Scleropages_formosus
ENSG00000116001TIA110092.181ENSSFOG00015018496-9992.181Scleropages_formosus
ENSG00000116001TIA110088.066ENSSMAG00000011347tia1l10088.066Scophthalmus_maximus
ENSG00000116001TIA110090.984ENSSMAG00000020230-9990.984Scophthalmus_maximus
ENSG00000116001TIA19089.781ENSSMAG00000012671tial19984.362Scophthalmus_maximus
ENSG00000116001TIA110087.705ENSSDUG00000023544tia1l10089.388Seriola_dumerili
ENSG00000116001TIA110091.393ENSSDUG00000003453-9991.393Seriola_dumerili
ENSG00000116001TIA110084.898ENSSDUG00000018021tial110084.898Seriola_dumerili
ENSG00000116001TIA110091.393ENSSLDG00000014625-9991.393Seriola_lalandi_dorsalis
ENSG00000116001TIA110084.898ENSSLDG00000020001tial110084.898Seriola_lalandi_dorsalis
ENSG00000116001TIA110087.705ENSSLDG00000011450tia1l10089.388Seriola_lalandi_dorsalis
ENSG00000116001TIA110099.123ENSSARG00000001997TIA110098.841Sorex_araneus
ENSG00000116001TIA110098.770ENSSPUG00000008547TIA110098.770Sphenodon_punctatus
ENSG00000116001TIA17258.095ENSSPAG00000002281-6557.944Stegastes_partitus
ENSG00000116001TIA110084.411ENSSPAG00000004511-10084.411Stegastes_partitus
ENSG00000116001TIA110082.449ENSSPAG00000000095tial110076.515Stegastes_partitus
ENSG00000116001TIA110086.885ENSSPAG00000008228tia1l10088.571Stegastes_partitus
ENSG00000116001TIA110099.590ENSSSCG00000023409TIA1100100.000Sus_scrofa
ENSG00000116001TIA19293.401ENSTGUG00000017307TIA110083.478Taeniopygia_guttata
ENSG00000116001TIA110087.295ENSTRUG00000005456tia1l10088.980Takifugu_rubripes
ENSG00000116001TIA110090.947ENSTRUG00000015136-10090.947Takifugu_rubripes
ENSG00000116001TIA110087.698ENSTNIG00000011433-10087.698Tetraodon_nigroviridis
ENSG00000116001TIA110083.529ENSTNIG00000013470tia1l10085.156Tetraodon_nigroviridis
ENSG00000116001TIA18877.692ENSTBEG00000008045-10062.435Tupaia_belangeri
ENSG00000116001TIA192100.000ENSTBEG00000017228TIA110091.192Tupaia_belangeri
ENSG00000116001TIA110098.246ENSTTRG00000001195TIA110098.187Tursiops_truncatus
ENSG00000116001TIA110099.590ENSUAMG00000025833TIA110099.590Ursus_americanus
ENSG00000116001TIA110099.590ENSUMAG00000021459TIA110099.590Ursus_maritimus
ENSG00000116001TIA19993.363ENSVPAG00000007449TIA110089.378Vicugna_pacos
ENSG00000116001TIA110099.123ENSVVUG00000028040TIA19698.421Vulpes_vulpes
ENSG00000116001TIA110088.235ENSXETG00000008514tia110088.235Xenopus_tropicalis
ENSG00000116001TIA110089.754ENSXCOG00000008899-10089.388Xiphophorus_couchianus
ENSG00000116001TIA110084.411ENSXCOG00000017733tia1l10084.411Xiphophorus_couchianus
ENSG00000116001TIA19079.310ENSXCOG00000006063tial110069.610Xiphophorus_couchianus
ENSG00000116001TIA110089.712ENSXMAG00000018689tia1l10089.712Xiphophorus_maculatus
ENSG00000116001TIA19083.942ENSXMAG00000027915tial110071.088Xiphophorus_maculatus
ENSG00000116001TIA110089.754ENSXMAG00000023528-10089.754Xiphophorus_maculatus
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0003723RNA binding22658674.22681889.HDAFunction
GO:0005515protein binding7544399.12486009.IPIFunction
GO:0005654nucleoplasm-IDAComponent
GO:0005654nucleoplasm-TASComponent
GO:0005737cytoplasm24965446.IDAComponent
GO:0005829cytosol-IDAComponent
GO:0006915apoptotic process-IEAProcess
GO:0008143poly(A) binding1934064.TASFunction
GO:0008543fibroblast growth factor receptor signaling pathway-TASProcess
GO:0010494cytoplasmic stress granule21984414.IDAComponent
GO:0010494cytoplasmic stress granule-ISSComponent
GO:0017091AU-rich element binding-IEAFunction
GO:0017148negative regulation of translation-IEAProcess
GO:0042036negative regulation of cytokine biosynthetic process-IEAProcess
GO:0048024regulation of mRNA splicing, via spliceosome11106748.IDAProcess
GO:0097165nuclear stress granule21984414.IDAComponent
GO:1903608protein localization to cytoplasmic stress granule24965446.IMPProcess
GO:1904037positive regulation of epithelial cell apoptotic process-IEAProcess
To top

Copyright © , Bioinformatics Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, China. All Rights Reserved.

Any comment and suggestion, please contact us