EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr2	189468559	Silent	NA	L571L	0.06
BLCA	chr2	189470096	Missense_Mutation	novel	E614K	0.34
BLCA	chr2	189470128	Missense_Mutation	NA	I624M	0.34
BLCA	chr2	189466558	Nonsense_Mutation	novel	I474_L475ins*	0.08
BRCA	chr2	189467579	Missense_Mutation	NA	I520T	0.66
BRCA	chr2	189462504	Missense_Mutation	rs147809896	G267S	0.15
BRCA	chr2	189467511	Silent	rs754785406	H497H	0.05
BRCA	chr2	189458770	Nonsense_Mutation	NA	S196*	0.39
BRCA	chr2	189451886	Missense_Mutation	novel	E122K	0.17
BRCA	chr2	189467583	Silent	novel	V521V	0.25
BRCA	chr2	189475358	Missense_Mutation	rs146243526	E812K	0.17
BRCA	chr2	189450688	Intron	novel		0.28
CESC	chr2	189463940	Missense_Mutation	NA	Q364H	0.25
CESC	chr2	189449400	Intron	novel		0.46
CESC	chr2	189465243	Silent	NA	K426K	0.27
CESC	chr2	189441441	5'UTR	novel		0.17
CESC	chr2	189459391	Missense_Mutation	novel	D249H	0.25
COAD	chr2	189468561	Missense_Mutation	NA	S572N	0.14
COAD	chr2	189467552	Missense_Mutation	novel	S511Y	0.33
COAD	chr2	189470099	Missense_Mutation	novel	P615S	0.27
COAD	chr2	189467552	Missense_Mutation	novel	S511F	0.36
COAD	chr2	189475501	3'UTR	novel		0.4
COAD	chr2	189463916	Silent	novel	G356G	0.33
COAD	chr2	189450863	Intron	novel		0.45
COAD	chr2	189450864	Intron	novel		0.26
COAD	chr2	189462533	Silent	rs150976700	R276R	0.32
COAD	chr2	189450864	Intron	novel		0.31
COAD	chr2	189450801	Intron	novel		0.13
COAD	chr2	189470150	Nonsense_Mutation	novel	G632*	0.08
COAD	chr2	189450863	Intron	novel		0.39
COAD	chr2	189475380	Missense_Mutation	novel	F819C	0.09
COAD	chr2	189467632	Nonsense_Mutation	NA	R538*	0.32
COAD	chr2	189475366	Silent	NA	K814K	0.36
ESCA	chr2	189475354	Missense_Mutation	novel	K810N	0.11
GBM	chr2	189448474	Missense_Mutation	novel	T61I	0.45
GBM	chr2	189467538	Missense_Mutation	novel	F506L	0.58
GBM	chr2	189467542	Missense_Mutation	rs371434035	E508K	0.13
KIRC	chr2	189459339	Silent	NA	R231R	0.13
KIRC	chr2	189465196	Frame_Shift_Ins	novel	*K411Mfs20**	0.05
KIRC	chr2	189475379	Nonsense_Mutation	novel	*F819delinsYKHYMFLNSNFLI**	0.07
LGG	chr2	189448397	Silent	NA	S35S	0.39
LGG	chr2	189475398	Missense_Mutation	novel	S825N	0.25
LGG	chr2	189466576	In_Frame_Ins	novel	I481delinsML	0.11
LGG	chr2	189466578	Missense_Mutation	novel	I481M	0.11
LUAD	chr2	189463868	Missense_Mutation	novel	L340F	0.15
LUAD	chr2	189450959	Silent	NA	I91I	0.33
LUAD	chr2	189465188	Missense_Mutation	novel	R408L	0.12
LUAD	chr2	189465189	Silent	novel	R408R	0.12
LUAD	chr2	189458855	Missense_Mutation	novel	D224E	0.18
LUAD	chr2	189458856	Missense_Mutation	novel	G225C	0.17
LUAD	chr2	189450792	Intron	novel		0.5
LUAD	chr2	189470853	Missense_Mutation	novel	E675G	0.15
LUAD	chr2	189475348	Frame_Shift_Del	novel	*L808Ffs9**	0.3
LUAD	chr2	189475344	Missense_Mutation	novel	Q807R	0.42
LUAD	chr2	189469399	Silent	NA	E593E	0.23
LUAD	chr2	189470121	Frame_Shift_Ins	novel	*I624Yfs18**	0.22
LUAD	chr2	189474774	Missense_Mutation	novel	V752L	0.32
LUSC	chr2	189451802	Splice_Region	novel		0.11
LUSC	chr2	189466515	Silent	NA	T460T	0.27
LUSC	chr2	189459339	Silent	NA	R231R	0.14
LUSC	chr2	189470140	Missense_Mutation	novel	K628N	0.24
LUSC	chr2	189466537	Missense_Mutation	NA	G468S	0.11
LUSC	chr2	189475398	Missense_Mutation	novel	S825I	0.08
LUSC	chr2	189475400	In_Frame_Ins	novel	W826delinsFR	0.08
LUSC	chr2	189470857	Missense_Mutation	NA	K676N	0.24
LUSC	chr2	189475301	Missense_Mutation	NA	Q793E	0.84
MESO	chr2	189459392	Missense_Mutation	rs779064956	D249G	0.26
OV	chr2	189470140	Frame_Shift_Ins	novel	*V629Wfs34**	0.04
OV	chr2	189474748	Missense_Mutation	NA	S743C	0.23
OV	chr2	189455378	Silent	novel	A144A	0.21
OV	chr2	189462532	Missense_Mutation	rs148423434	R276H	0.18
PCPG	chr2	189474731	Silent	novel	P737P	0.1
PRAD	chr2	189450942	Missense_Mutation	novel	D86Y	0.27
READ	chr2	189458865	Missense_Mutation	NA	R228C	0.15
READ	chr2	189448467	Silent	NA	L59L	0.14
READ	chr2	189462503	Silent	rs777081441	G266G	0.33
READ	chr2	189450864	Intron	novel		0.26
SARC	chr2	189462605	Frame_Shift_Del	novel	*A301Dfs9**	0.52
SKCM	chr2	189463938	Nonsense_Mutation	NA	Q364*	0.43
SKCM	chr2	189470091	Missense_Mutation	NA	P612L	0.23
SKCM	chr2	189458865	Missense_Mutation	NA	R228C	0.33
SKCM	chr2	189441498	Silent	novel	V2V	0.5
SKCM	chr2	189462565	Missense_Mutation	NA	P287L	0.29
SKCM	chr2	189463712	Missense_Mutation	rs144965982	R319Q	0.32
SKCM	chr2	189475361	Missense_Mutation	NA	E813K	0.15
SKCM	chr2	189475351	Silent	novel	S809S	0.26
SKCM	chr2	189470144	Nonsense_Mutation	NA	Q630*	0.31
SKCM	chr2	189458865	Missense_Mutation	NA	R228C	0.3
SKCM	chr2	189462563	Silent	rs375185814	L286L	0.1
SKCM	chr2	189457333	Missense_Mutation	rs748227202	R174Q	0.55
SKCM	chr2	189474187	Missense_Mutation	NA	L684Q	0.33
SKCM	chr2	189459416	Missense_Mutation	NA	S257L	0.19
SKCM	chr2	189450820	Intron	novel		0.23
SKCM	chr2	189467540	Missense_Mutation	NA	S507F	0.42
STAD	chr2	189463696	Missense_Mutation	novel	I314V	0.17
STAD	chr2	189455334	Missense_Mutation	novel	V130F	0.08
STAD	chr2	189475451	3'UTR	novel		0.46
STAD	chr2	189475452	3'UTR	novel		0.31
STAD	chr2	189462531	Missense_Mutation	novel	R276C	0.26
STAD	chr2	189455360	Silent	NA	S138S	0.18
STAD	chr2	189465248	Missense_Mutation	NA	T428I	0.12
THCA	chr2	189475465	3'UTR	novel		0.11
THCA	chr2	189466577	Frame_Shift_Ins	novel	*I481Mfs13**	0.04
UCEC	chr2	189466459	Frame_Shift_Ins	novel	*D443Rfs10**	0.04
UCEC	chr2	189475472	3'UTR	novel		0.38
UCEC	chr2	189450837	Intron	novel		0.39
UCEC	chr2	189449416	Intron	novel		0.25
UCEC	chr2	189463704	Silent	novel	I316I	0.45
UCEC	chr2	189475251	Missense_Mutation	novel	E776G	0.2
UCEC	chr2	189462531	Missense_Mutation	novel	R276C	0.32
UCEC	chr2	189474752	Silent	NA	A744A	0.59
UCEC	chr2	189465200	Missense_Mutation	NA	E412G	0.33
UCEC	chr2	189450907	Missense_Mutation	NA	Y74C	0.24
UCEC	chr2	189475358	Missense_Mutation	rs146243526	E812K	0.32
UCEC	chr2	189448503	Silent	novel	L71L	0.17
UCEC	chr2	189475487	3'UTR	novel		0.14
UCEC	chr2	189441557	Missense_Mutation	novel	A22V	0.13
UCEC	chr2	189462533	Silent	rs150976700	R276R	0.13
UCEC	chr2	189450855	Intron	novel		0.4
UCEC	chr2	189450910	Missense_Mutation	novel	S75F	0.12
UCEC	chr2	189465134	Missense_Mutation	novel	L390R	0.17
UCEC	chr2	189463700	Missense_Mutation	novel	I315R	0.46
UCEC	chr2	189463898	Silent	novel	V350V	0.6
UCEC	chr2	189474204	Missense_Mutation	rs768641297	L690I	0.39
UCEC	chr2	189462508	Missense_Mutation	rs528766591	R268H	0.19
UCEC	chr2	189449406	Intron	novel		0.5
UCEC	chr2	189450864	Intron	novel		0.45
UCEC	chr2	189475268	Missense_Mutation	novel	S782A	0.34
UCEC	chr2	189469396	Silent	NA	S592S	0.24
UCEC	chr2	189441564	Silent	novel	F24F	0.29
UCEC	chr2	189467552	Missense_Mutation	novel	S511Y	0.4
UCEC	chr2	189475528	3'UTR	novel		0.13
UCEC	chr2	189465228	Silent	novel	L421L	0.43
UCEC	chr2	189449447	Intron	novel		0.57
UCEC	chr2	189468519	Missense_Mutation	novel	G558A	0.41
UCEC	chr2	189459362	Missense_Mutation	novel	Y239C	0.61
UCEC	chr2	189462561	Missense_Mutation	novel	L286I	0.25
UCEC	chr2	189468539	Missense_Mutation	NA	L565I	0.2
UCEC	chr2	189459362	Missense_Mutation	novel	Y239C	0.37
UCEC	chr2	189465189	Silent	novel	R408R	0.51
UCEC	chr2	189465202	Missense_Mutation	novel	T413A	0.3
UCEC	chr2	189468506	Missense_Mutation	novel	K554E	0.27
UCEC	chr2	189450851	Intron	novel		0.1
UCEC	chr2	189474781	Nonsense_Mutation	novel	S754*	0.18
UCEC	chr2	189449290	Intron	novel		0.24
UCEC	chr2	189450864	Intron	novel		0.28
UCEC	chr2	189475484	3'UTR	novel		0.57
UCEC	chr2	189450864	Intron	novel		0.09
UCEC	chr2	189466446	Silent	NA	I437I	0.35
UCEC	chr2	189474789	Silent	novel	L757L	0.21
UCEC	chr2	189467585	Missense_Mutation	NA	T522I	0.38
UCEC	chr2	189468539	Missense_Mutation	NA	L565I	0.22
UCEC	chr2	189475421	3'UTR	novel		0.18
UCEC	chr2	189459365	Missense_Mutation	novel	T240M	0.25
UCEC	chr2	189455384	Silent	novel	E146E	0.33

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
CESC	AMP	0.1322	0.012962
PAAD	AMP	0.0652	0.1091
PAAD	DEL	0.0326	0.2014

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.00066	Kaplan-Meier Survival Analysis
MESO	0.0022	Kaplan-Meier Survival Analysis
ACC	0.0001	Kaplan-Meier Survival Analysis
SKCM	0.023	Kaplan-Meier Survival Analysis
KIRP	0.00023	Kaplan-Meier Survival Analysis
PAAD	0.016	Kaplan-Meier Survival Analysis
BLCA	0.049	Kaplan-Meier Survival Analysis
LIHC	0.0001	Kaplan-Meier Survival Analysis
LUAD	0.017	Kaplan-Meier Survival Analysis

Description

RBPome

Expression

Transcripts

Gene Model

Pathway

Phenotype

PPI

Ortholog

Gene Ontology

Description

Ensembl ID: ENSG00000115368 (Gene tree)
Gene ID: 84128
Gene Symbol: WDR75
Alias: FLJ12519|NET16|UTP17
Full Name: WD repeat domain 75
Gene Type: protein_coding
Specie: Homo_sapiens
Strand: Plus strand
Length: 34,133 bases
Position: chr2:189,441,433-189,475,565
Accession: 25725
Summary: (WD Repeat Domain 75) is a Protein Coding gene. Among its related pathways are rRNA processing in the nucleus and cytosol and Gene Expression. An important paralog of this gene is TEP1.

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	NascentRICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	PolyT & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	polyT & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30352994	Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome capture	RIC & Jurkat	2018 Oct 23	Perez-Perri JI	DOI:10.1038/s41467-018-06557-8

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000498365	WDR75-206	677	-	-	- (aa)	-	-
ENST00000472286	WDR75-204	706	-	-	- (aa)	-	-
ENST00000436347	WDR75-203	2703	-	ENSP00000414226	89 (aa)	-	F8WE20
ENST00000631047	WDR75-207	270	-	ENSP00000486831	89 (aa)	-	F8WE20
ENST00000427960	WDR75-202	4297	-	ENSP00000400728	97 (aa)	-	F8WC81
ENST00000475596	WDR75-205	552	-	-	- (aa)	-	-
ENST00000314761	WDR75-201	2701	XM_024453168	ENSP00000314193	830 (aa)	XP_024308936	Q8IWA0

Gene Model

Click here to download 's gene model file

Pathway

Pathway ID	Pathway Name	Source
hsa03008	Ribosome biogenesis in eukaryotes	KEGG

Phenotype

ensgID	Trait	pValue	Pubmed ID
ENSG00000115368	Iron	1E-11	25352340
ENSG00000115368	Transferrin	1E-11	25352340
ENSG00000115368	Ferritins	8E-19	25352340
ENSG00000115368	Iron	8E-19	25352340

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000115368's network

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy	Species
ENSG00000115368	WDR75	99	84.903	ENSMUSG00000025995	Wdr75	99	84.903	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003723	RNA binding	22658674.22681889.	HDA	Function
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005730	nucleolus	17699751.	IDA	Component
GO:0006364	rRNA processing	-	TAS	Process
GO:0045943	positive regulation of transcription by RNA polymerase I	17699751.	IMP	Process
GO:2000234	positive regulation of rRNA processing	17699751.	IMP	Process

Note: Click here to get the extension of tumor abbreviations.

Note: to get the extension of tumor abbreviations.