EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
24966913	Nogo-C contributes to HCC tumorigenesis via suppressing cell growth and its interactome analysis with comparative proteomics research.	Int J Clin Exp Pathol	2014 Apr 15	Liu X	-
12510146	Multi-functional gene ASY/Nogo/RTN-X/RTN4: apoptosis, tumor suppression, and inhibition of neuronal regeneration.	Apoptosis	2003 Jan	Watari A	-
12618765	Do cancer cells die because of Nogo-B?	Oncogene	2003 Mar 6	Oertle T	-
23042479	Nogo-B promotes the epithelial-mesenchymal transition in HeLa cervical cancer cells via Fibulin-5.	Oncol Rep	2013 Jan	Xiao W	doi: 10.3892/or.2012.2069
25847052	Knockdown of reticulon 4C by lentivirus inhibits human colorectal cancer cell growth.	Mol Med Rep	2015 Aug	Xue H	doi: 10.3892/mmr.2015.3569
29684585	Nogo-B (Reticulon-4B) functions as a negative regulator of the apoptotic pathway through the interaction with c-FLIP in colorectal cancer cells.	Biochim Biophys Acta Mol Basis Dis	2018 Aug	Kawaguchi N	doi: 10.1016/j.bbadis.2018.04.018

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr2	55025283	Missense_Mutation	novel	S939F	0.47
BLCA	chr2	55010131	Intron	novel		0.42
BLCA	chr2	55026102	Missense_Mutation	novel	S666L	0.21
BLCA	chr2	55025684	Silent	novel	L805L	0.7
BLCA	chr2	55026658	Missense_Mutation	NA	P481S	0.14
BLCA	chr2	54973609	Missense_Mutation	novel	H1164Y	0.6
BLCA	chr2	55027486	Splice_Site	novel	X205_splice	0.66
BLCA	chr2	55025252	Silent	rs201878803	L949L	0.51
BLCA	chr2	55026682	Missense_Mutation	NA	E473K	0.38
BLCA	chr2	55026406	Nonsense_Mutation	NA	E565*	0.37
BLCA	chr2	55027111	Missense_Mutation	novel	E330K	0.24
BLCA	chr2	54987664	Missense_Mutation	novel	K1016N	0.4
BRCA	chr2	55026838	Missense_Mutation	NA	D421H	0.24
BRCA	chr2	55025413	In_Frame_Ins	novel	S895_H896insYKHNIK	0.14
BRCA	chr2	54982516	Missense_Mutation	NA	K1120T	0.35
BRCA	chr2	54973128	3'UTR	rs545543647		0.04
BRCA	chr2	55010300	Intron	novel		0.3
BRCA	chr2	55026321	Missense_Mutation	novel	A593E	0.45
BRCA	chr2	55026525	Missense_Mutation	NA	S525F	0.21
BRCA	chr2	55026139	Missense_Mutation	NA	E654K	0.5
BRCA	chr2	55025301	Missense_Mutation	NA	S933T	0.22
BRCA	chr2	54987493	Splice_Region	rs763734917	F1073F	0.37
BRCA	chr2	54972946	3'UTR	novel		0.08
BRCA	chr2	54972256	3'UTR	novel		0.33
BRCA	chr2	55010299	Intron	novel		0.41
BRCA	chr2	55010130	Intron	novel		0.05
BRCA	chr2	55026950	Nonsense_Mutation	novel	*E383Dfs3**	0.04
BRCA	chr2	54982579	Missense_Mutation	NA	V1099G	0.23
CESC	chr2	55026784	Missense_Mutation	novel	E439Q	0.05
CESC	chr2	55026389	Missense_Mutation	NA	K570N	0.31
CESC	chr2	55026758	Silent	NA	F447F	0.14
CESC	chr2	55025155	Missense_Mutation	NA	P982S	0.26
CESC	chr2	55025904	Missense_Mutation	NA	S732C	0.31
CESC	chr2	54973865	Frame_Shift_Ins	novel	*L1145Afs12**	0.08
CESC	chr2	55026403	Missense_Mutation	novel	V566I	0.35
CESC	chr2	55027228	Missense_Mutation	NA	E291K	0.53
CESC	chr2	55025151	Missense_Mutation	novel	S983F	0.45
CESC	chr2	55025567	In_Frame_Ins	novel	D844dup	0.03
COAD	chr2	54973043	3'UTR	novel		0.3
COAD	chr2	55025989	Nonsense_Mutation	NA	E704*	0.2
COAD	chr2	55026395	Silent	NA	G568G	0.43
COAD	chr2	55027484	Missense_Mutation	NA	E205D	0.37
COAD	chr2	55026092	Frame_Shift_Del	NA	*V670Yfs4**	0.31
COAD	chr2	55025306	Missense_Mutation	NA	K931N	0.31
COAD	chr2	55026092	Frame_Shift_Del	NA	*V670Yfs4**	0.35
COAD	chr2	55026271	Missense_Mutation	NA	V610I	0.36
COAD	chr2	55025417	Silent	novel	V894V	0.06
COAD	chr2	55027080	Frame_Shift_Ins	novel	*L340Pfs3**	0.04
COAD	chr2	55026092	Frame_Shift_Del	NA	*V670Yfs4**	0.27
COAD	chr2	54973829	Missense_Mutation	rs777282392	R1157W	0.36
COAD	chr2	55026091	Frame_Shift_Ins	NA	*V670Sfs9**	0.38
COAD	chr2	54987561	Missense_Mutation	NA	T1051A	0.31
COAD	chr2	54987678	Nonsense_Mutation	novel	R1012*	0.12
COAD	chr2	54973161	Nonsense_Mutation	novel	E1192*	0.41
COAD	chr2	55026843	Missense_Mutation	NA	K419T	0.26
COAD	chr2	55026961	Missense_Mutation	rs749220120	M380V	0.2
COAD	chr2	54973154	3'UTR	novel		0.12
COAD	chr2	55025730	Missense_Mutation	rs779152319	A790V	0.38
COAD	chr2	55025297	Missense_Mutation	NA	F934L	0.34
COAD	chr2	55027357	Nonsense_Mutation	NA	E248*	0.3
COAD	chr2	55026092	Frame_Shift_Del	NA	*V670Yfs4**	0.18
COAD	chr2	55025195	Frame_Shift_Ins	novel	*K969Efs10**	0.04
COAD	chr2	55025537	Frame_Shift_Ins	novel	*R854Sfs2**	0.05
COAD	chr2	55025538	Missense_Mutation	novel	R854I	0.05
COAD	chr2	55026830	Frame_Shift_Del	NA	*K423Nfs32**	0.38
ESCA	chr2	55025272	Missense_Mutation	novel	S943P	0.1
ESCA	chr2	54982552	Missense_Mutation	NA	R1108H	0.19
ESCA	chr2	54972723	3'UTR	novel		0.95
GBM	chr2	55025210	Missense_Mutation	novel	E963D	0.29
GBM	chr2	55025794	Nonsense_Mutation	NA	E769*	0.32
GBM	chr2	55026095	Missense_Mutation	novel	K668N	0.28
GBM	chr2	55026535	Missense_Mutation	novel	A522T	0.27
HNSC	chr2	55025497	Missense_Mutation	rs757479536	I868V	0.2
HNSC	chr2	55025116	Missense_Mutation	rs201229603	I995V	0.27
HNSC	chr2	55027428	Missense_Mutation	novel	F224S	0.24
HNSC	chr2	55025446	Missense_Mutation	novel	L885V	0.65
HNSC	chr2	55025490	Missense_Mutation	novel	E870V	0.13
HNSC	chr2	55027438	Nonsense_Mutation	novel	Q221*	0.17
HNSC	chr2	55026894	Missense_Mutation	novel	D402G	0.18
HNSC	chr2	55025503	Nonsense_Mutation	novel	E866*	0.3
HNSC	chr2	55028187	Missense_Mutation	novel	E197V	0.24
HNSC	chr2	54982533	Frame_Shift_Ins	novel	*D1114Efs4**	0.15
HNSC	chr2	54982620	Silent	novel	E1085E	0.34
KICH	chr2	55027159	Missense_Mutation	rs144622313	V314I	0.35
KIRC	chr2	55026696	Missense_Mutation	NA	N468T	0.08
KIRC	chr2	54987497	Missense_Mutation	novel	P1072L	0.2
KIRP	chr2	55026377	Missense_Mutation	NA	E574D	0.24
KIRP	chr2	55026378	Missense_Mutation	NA	E574A	0.23
LAML	chr2	55026587	Missense_Mutation	novel	I504M	0.09
LAML	chr2	55026642	Missense_Mutation	novel	P486H	0.07
LGG	chr2	55026278	In_Frame_Del	novel	P607del	0.43
LIHC	chr2	55050329	5'UTR	novel		0.67
LIHC	chr2	55025972	Silent	novel	A709A	0.6
LIHC	chr2	55025178	Missense_Mutation	NA	V974A	0.26
LIHC	chr2	55027045	Missense_Mutation	NA	K352E	0.45
LIHC	chr2	54974739	Missense_Mutation	novel	T1129I	0.44
LIHC	chr2	55027480	Missense_Mutation	NA	M207V	0.24
LIHC	chr2	55027482	Missense_Mutation	NA	N206T	0.26
LIHC	chr2	55026740	Silent	novel	G453G	0.33
LUAD	chr2	55026649	Nonsense_Mutation	NA	G484*	0.32
LUAD	chr2	55026689	Silent	novel	A470A	0.4
LUAD	chr2	55026009	Missense_Mutation	NA	I697T	0.34
LUAD	chr2	55026580	Missense_Mutation	NA	E507K	0.18
LUAD	chr2	55025569	Missense_Mutation	NA	D844Y	0.12
LUAD	chr2	55025525	Silent	rs147365678	T858T	0.21
LUAD	chr2	55026206	Silent	novel	V631V	0.11
LUAD	chr2	55026964	Missense_Mutation	NA	P379A	0.14
LUAD	chr2	55010092	Intron	rs369483079		0.27
LUSC	chr2	55026389	Silent	novel	K570K	0.23
LUSC	chr2	55025327	Missense_Mutation	novel	I924M	0.14
LUSC	chr2	55025976	Missense_Mutation	novel	S708F	0.18
LUSC	chr2	55050279	Missense_Mutation	rs201003451	P8S	0.16
LUSC	chr2	55025383	Nonsense_Mutation	novel	G906*	0.37
LUSC	chr2	55025971	Missense_Mutation	novel	E710K	0.26
LUSC	chr2	55027398	Missense_Mutation	NA	S234C	0.18
LUSC	chr2	55026449	Silent	NA	L550L	0.39
LUSC	chr2	54987579	Missense_Mutation	novel	L1045V	0.35
LUSC	chr2	55027103	Silent	novel	E332E	0.32
LUSC	chr2	55027445	Silent	novel	S218S	0.17
LUSC	chr2	55026511	Missense_Mutation	NA	V530L	0.3
LUSC	chr2	55026092	Frame_Shift_Del	NA	*V670Yfs4**	0.35
LUSC	chr2	55027370	Silent	rs202014771	A243A	0.14
LUSC	chr2	55050211	Missense_Mutation	novel	E30D	0.16
LUSC	chr2	55026349	Missense_Mutation	novel	E584K	0.21
OV	chr2	54987700	Splice_Site	NA	X1005_splice	0.23
OV	chr2	55025829	Missense_Mutation	NA	P757L	0.2
OV	chr2	54972946	3'UTR	novel		0.22
OV	chr2	55025556	Missense_Mutation	rs144867063	S848C	0.44
PAAD	chr2	55025772	Missense_Mutation	novel	F776C	0.11
PAAD	chr2	55025202	Missense_Mutation	rs760996053	S966N	0.08
PAAD	chr2	55026167	Silent	novel	V644V	0.18
PCPG	chr2	55025771	Frame_Shift_Del	novel	*F776Sfs3**	0.21
PCPG	chr2	55010174	Intron	novel		0.36
PRAD	chr2	55050414	5'UTR	novel		0.6
PRAD	chr2	55026999	Missense_Mutation	novel	D367V	0.4
READ	chr2	55025621	Missense_Mutation	novel	E826D	0.46
READ	chr2	55025699	Missense_Mutation	novel	L800F	0.4
READ	chr2	55027365	Missense_Mutation	novel	S245Y	0.45
READ	chr2	55027045	Missense_Mutation	NA	K352Q	0.45
SKCM	chr2	55027191	Missense_Mutation	rs143123978	S303L	0.29
SKCM	chr2	55027327	Missense_Mutation	NA	V258I	0.46
SKCM	chr2	54973128	3'UTR	rs545543647		0.24
SKCM	chr2	55050174	Missense_Mutation	novel	E43K	0.13
SKCM	chr2	54973614	Missense_Mutation	NA	I1162K	0.59
SKCM	chr2	55025086	Missense_Mutation	NA	V1005I	0.31
SKCM	chr2	55010202	Intron	novel		0.21
SKCM	chr2	55026412	Missense_Mutation	NA	L563M	0.3
SKCM	chr2	55026855	Missense_Mutation	NA	N415S	0.09
SKCM	chr2	54973182	Missense_Mutation	novel	P1185S	0.21
STAD	chr2	55026092	Frame_Shift_Del	novel	*K669Sfs9**	0.34
STAD	chr2	54973097	3'UTR	rs182249122		0.6
STAD	chr2	55025583	Missense_Mutation	NA	V839A	0.11
STAD	chr2	55027386	Missense_Mutation	NA	L238P	0.35
STAD	chr2	55027100	Silent	novel	K333K	0.06
STAD	chr2	55025198	Missense_Mutation	rs199592685	I967M	0.26
STAD	chr2	55026779	Missense_Mutation	novel	S440R	0.07
STAD	chr2	54982552	Missense_Mutation	NA	R1108H	0.26
STAD	chr2	55027286	Silent	NA	E271E	0.2
THCA	chr2	55026104	In_Frame_Ins	novel	V665_S666insES	0.09
THCA	chr2	55025191	Frame_Shift_Ins	novel	*P970Tfs15**	0.07
UCEC	chr2	55026092	Frame_Shift_Del	NA	*V670Yfs4**	0.41
UCEC	chr2	55025960	Silent	rs201182840	P713P	0.28
UCEC	chr2	55026072	Missense_Mutation	NA	E676A	0.3
UCEC	chr2	54973054	3'UTR	novel		0.39
UCEC	chr2	55025725	Missense_Mutation	novel	P792S	0.33
UCEC	chr2	55025227	Silent	novel	L958L	0.28
UCEC	chr2	55026135	Missense_Mutation	novel	N655T	0.23
UCEC	chr2	55025084	Splice_Site	novel	X1005_splice	0.26
UCEC	chr2	55026749	Silent	rs368773344	T450T	0.33
UCEC	chr2	55025413	In_Frame_Ins	novel	S895_H896insYKHNIK	0.25
UCEC	chr2	55025379	Missense_Mutation	rs761530879	A907V	0.43
UCEC	chr2	54982591	Missense_Mutation	novel	A1095D	0.19
UCEC	chr2	54972981	3'UTR	novel		0.42
UCEC	chr2	55026092	Frame_Shift_Del	NA	*V670Yfs4**	0.29
UCEC	chr2	55027335	Missense_Mutation	novel	L255S	0.39
UCEC	chr2	55026465	Missense_Mutation	NA	N545T	0.45
UCEC	chr2	55025413	Nonsense_Mutation	novel	*H896Tfs6**	0.11
UCEC	chr2	55025525	Silent	rs147365678	T858T	0.05
UCEC	chr2	55025413	In_Frame_Ins	novel	S895_H896insYKHNIK	0.22
UCEC	chr2	55027357	Nonsense_Mutation	NA	E248*	0.2
UCEC	chr2	54987675	Missense_Mutation	NA	D1013Y	0.18
UCEC	chr2	55026502	Missense_Mutation	NA	D533N	0.54
UCEC	chr2	54973850	Missense_Mutation	novel	S1150G	0.57
UCEC	chr2	54972305	3'UTR	novel		0.18
UCEC	chr2	55025665	Missense_Mutation	rs762033500	D812Y	0.29
UCEC	chr2	55027097	Missense_Mutation	novel	L334F	0.13
UCEC	chr2	54973014	3'UTR	novel		0.33
UCEC	chr2	55025474	Silent	novel	I875I	0.33
UCEC	chr2	55025934	Missense_Mutation	novel	A722V	0.33
UCEC	chr2	54973042	3'UTR	rs192549959		0.32
UCEC	chr2	55025387	Silent	rs142717278	P904P	0.33
UCEC	chr2	55025737	Missense_Mutation	novel	L788F	0.32
UCEC	chr2	55025589	Missense_Mutation	novel	T837I	0.5
UCEC	chr2	55026062	Silent	novel	E679E	0.37
UCEC	chr2	55026610	Frame_Shift_Del	rs761969807	I497*	0.47
UCEC	chr2	55026742	Missense_Mutation	novel	G453C	0.51
UCEC	chr2	55026616	Nonsense_Mutation	novel	K495*	0.48
UCEC	chr2	55025415	Frame_Shift_Ins	novel	*S895Cfs6**	0.2
UCEC	chr2	55026610	Frame_Shift_Del	rs761969807	I497*	0.35
UCEC	chr2	55026251	Missense_Mutation	NA	M616I	0.5
UCEC	chr2	55026948	Missense_Mutation	novel	Y384C	0.22
UCEC	chr2	55027118	Silent	novel	N327N	0.05
UCEC	chr2	55025386	Missense_Mutation	novel	D905N	0.21
UCEC	chr2	55026786	Missense_Mutation	novel	S438I	0.21
UCEC	chr2	55027103	Missense_Mutation	rs376197823	E332D	0.15
UCEC	chr2	55027340	Silent	novel	G253G	0.19
UCEC	chr2	55026921	Missense_Mutation	novel	V393A	0.38
UCEC	chr2	55025413	In_Frame_Ins	novel	S895_H896insYKHNIK	0.27
UCEC	chr2	55027148	Silent	rs748866329	A317A	0.37
UCEC	chr2	55010281	Intron	novel		0.6
UCEC	chr2	54973043	3'UTR	novel		0.48
UCEC	chr2	55026087	Nonsense_Mutation	novel	S671*	0.19
UCEC	chr2	55026445	Missense_Mutation	novel	P552T	0.32
UCEC	chr2	55025935	Missense_Mutation	NA	A722T	0.52
UCEC	chr2	55025694	Missense_Mutation	NA	S802Y	0.05
UCEC	chr2	55025794	Nonsense_Mutation	NA	E769*	0.33
UCEC	chr2	55026020	Silent	NA	P693P	0.25
UCEC	chr2	55026368	Missense_Mutation	novel	M577I	0.05
UCEC	chr2	55027147	Missense_Mutation	NA	N318H	0.29
UCEC	chr2	55025780	Silent	novel	E773E	0.22
UCEC	chr2	55026249	Missense_Mutation	novel	E617G	0.19
UCEC	chr2	55026092	Frame_Shift_Del	NA	*V670Yfs4**	0.16
UCEC	chr2	55027387	Silent	NA	L238L	0.06
UCEC	chr2	55025323	Missense_Mutation	NA	P926S	0.47
UCEC	chr2	55027136	Frame_Shift_Ins	novel	*E322Qfs3**	0.07
UCEC	chr2	55027137	Frame_Shift_Ins	novel	*E321Vfs14**	0.07
UCEC	chr2	55026701	Silent	novel	P466P	0.11
UCEC	chr2	55026622	Missense_Mutation	NA	D493N	0.44
UCEC	chr2	55027103	Missense_Mutation	rs376197823	E332D	0.03
UCEC	chr2	55026613	Frame_Shift_Ins	novel	*K496Qfs17**	0.04
UCEC	chr2	55027447	Missense_Mutation	novel	S218T	0.11
UCEC	chr2	54973614	Missense_Mutation	NA	I1162T	0.35
UCEC	chr2	54987664	Missense_Mutation	NA	K1016N	0.38
UCEC	chr2	55025359	Nonsense_Mutation	NA	E914*	0.46
UCEC	chr2	55025844	Nonsense_Mutation	novel	S752*	0.15
UCEC	chr2	55027468	Missense_Mutation	novel	E211K	0.12
UCEC	chr2	55028210	Silent	novel	L189L	0.15
UCEC	chr2	55026796	Missense_Mutation	rs765495887	E435K	0.49
UCEC	chr2	55027060	Missense_Mutation	novel	P347S	0.38
UCEC	chr2	54973097	3'UTR	rs182249122		0.36
UCEC	chr2	54973829	Missense_Mutation	rs777282392	R1157W	0.37

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
KIRP	DEL	0.0243	0.08832
PAAD	DEL	0.0652	0.2014

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.032	Kaplan-Meier Survival Analysis
STAD	0.0046	Kaplan-Meier Survival Analysis
MESO	0.00012	Kaplan-Meier Survival Analysis
HNSC	0.0017	Kaplan-Meier Survival Analysis
BRCA	0.016	Kaplan-Meier Survival Analysis
ESCA	0.045	Kaplan-Meier Survival Analysis
KIRP	0.0047	Kaplan-Meier Survival Analysis
CESC	0.0011	Kaplan-Meier Survival Analysis
LAML	0.0078	Kaplan-Meier Survival Analysis
GBM	0.0047	Kaplan-Meier Survival Analysis
LUAD	0.025	Kaplan-Meier Survival Analysis
UVM	0.035	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000115310 (Gene tree)
Gene ID: 57142
Gene Symbol: RTN4
Alias: NSP-CL|KIAA0886|NOGO|ASY
Full Name: reticulon 4
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 140,435 bases
Position: chr2:54,972,187-55,112,621
Accession: 14085
RBP type: non-canonical RBP
Summary: This gene belongs to the family of reticulon encoding genes. Reticulons are associated with the endoplasmic reticulum, and are involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells. The product of this gene is a potent neurite outgrowth inhibitor which may also help block the regeneration of the central nervous system in higher vertebrates. Alternatively spliced transcript variants derived both from differential splicing and differential promoter usage and encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000438462	RTN4-211	656	-	ENSP00000397808	203 (aa)	-	H7C106
ENST00000491592	RTN4-215	860	-	-	- (aa)	-	-
ENST00000357376	RTN4-203	4110	-	ENSP00000349944	986 (aa)	-	Q9NQC3
ENST00000486085	RTN4-214	955	-	ENSP00000489133	127 (aa)	-	A0A0U1RQR6
ENST00000485749	RTN4-213	832	-	-	- (aa)	-	-
ENST00000337526	RTN4-202	4790	-	ENSP00000337838	1192 (aa)	-	Q9NQC3
ENST00000394609	RTN4-205	1898	-	ENSP00000378107	199 (aa)	-	Q9NQC3
ENST00000357732	RTN4-204	2390	-	ENSP00000350365	392 (aa)	-	Q9NQC3
ENST00000317610	RTN4-201	2333	-	ENSP00000322147	373 (aa)	-	Q9NQC3
ENST00000402434	RTN4-207	1456	-	ENSP00000384825	345 (aa)	-	F8W914
ENST00000405240	RTN4-209	4061	-	ENSP00000384471	986 (aa)	-	Q9NQC3
ENST00000394611	RTN4-206	4161	-	ENSP00000378109	986 (aa)	-	Q9NQC3
ENST00000427710	RTN4-210	589	-	ENSP00000411628	91 (aa)	-	C9J685
ENST00000461004	RTN4-212	422	-	-	- (aa)	-	-
ENST00000404909	RTN4-208	4102	-	ENSP00000385650	986 (aa)	-	Q9NQC3

Gene Model

Click here to download ENSG00000115310's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa05010	Alzheimer disease	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000115310	Cholesterol, HDL	4.33236853163432E-5	17903299
ENSG00000115310	Lipids	5.81981414238621E-5	17903299
ENSG00000115310	Choice Behavior	5.38e-005	-
ENSG00000115310	Antihypertensive Agents	6.9390000E-005	-
ENSG00000115310	Antihypertensive Agents	7.4970000E-006	-
ENSG00000115310	Cholesterol, HDL	4.1790000E-005	-
ENSG00000115310	Cholesterol, HDL	3.8770000E-005	-
ENSG00000115310	Cholesterol, HDL	2.5150000E-005	-
ENSG00000115310	Cholesterol, HDL	4.0980000E-006	-
ENSG00000115310	Triglycerides	4.7880000E-005	-
ENSG00000115310	Platelet Function Tests	3.6900000E-006	-

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000115310	rs2920861	2	55090980	A	Self-reported math ability (MTAG)	30038396	[0.011-0.023] unit increase	0.017	EFO_0004875
ENSG00000115310	rs3806572	2	55011541	A	Major depressive disorder (probable)	29662059	[0.0043-0.0097] unit decrease	0.007	EFO_0003761
ENSG00000115310	rs7601895	2	55054765	?	Body mass index	30595370			EFO_0004340
ENSG00000115310	rs12479297	2	55044445	?	Red cell distribution width	30595370			EFO_0005192
ENSG00000115310	rs2920899	2	55052545	T	Systolic blood pressure	30224653	[0.13-0.24] mmHg increase	0.1851	EFO_0006335
ENSG00000115310	rs6545468	2	55050505	?	Mean corpuscular hemoglobin	30595370			EFO_0004527

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000115310's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000115310	RTN4	100	97.487	ENSMUSG00000020458	Rtn4	100	97.487	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0001825	blastocyst formation	-	IEA	Process
GO:0003723	RNA binding	22658674.	HDA	Function
GO:0005515	protein binding	11126360.16752908.19665976.21516116.25416956.26906412.	IPI	Function
GO:0005635	nuclear envelope	11126360.	IDA	Component
GO:0005783	endoplasmic reticulum	16791210.	HDA	Component
GO:0005783	endoplasmic reticulum	-	IDA	Component
GO:0005783	endoplasmic reticulum	11126360.	NAS	Component
GO:0005789	endoplasmic reticulum membrane	25612671.26906412.	IDA	Component
GO:0005886	plasma membrane	-	TAS	Component
GO:0006915	apoptotic process	11126360.	NAS	Process
GO:0007413	axonal fasciculation	21873635.	IBA	Process
GO:0007413	axonal fasciculation	-	ISS	Process
GO:0010634	positive regulation of epithelial cell migration	27353365.	IMP	Process
GO:0014069	postsynaptic density	-	IEA	Component
GO:0021801	cerebral cortex radial glia guided migration	-	ISS	Process
GO:0030054	cell junction	-	IEA	Component
GO:0030176	integral component of endoplasmic reticulum membrane	10667797.	IDA	Component
GO:0030308	negative regulation of cell growth	20463223.	IMP	Process
GO:0030517	negative regulation of axon extension	10667797.	IDA	Process
GO:0031625	ubiquitin protein ligase binding	27353365.	IPI	Function
GO:0033601	positive regulation of mammary gland epithelial cell proliferation	27353365.	IMP	Process
GO:0034165	positive regulation of toll-like receptor 9 signaling pathway	-	ISS	Process
GO:0042981	regulation of apoptotic process	11126360.	NAS	Process
GO:0042995	cell projection	-	IEA	Component
GO:0043025	neuronal cell body	-	IEA	Component
GO:0045296	cadherin binding	25468996.	HDA	Function
GO:0050771	negative regulation of axonogenesis	-	TAS	Process
GO:0050821	protein stabilization	27353365.	IMP	Process
GO:0051292	nuclear pore complex assembly	26906412.	IMP	Process
GO:0051897	positive regulation of protein kinase B signaling	27353365.	IMP	Process
GO:0060317	cardiac epithelial to mesenchymal transition	-	IEA	Process
GO:0061462	protein localization to lysosome	-	ISS	Process
GO:0071782	endoplasmic reticulum tubular network	27353365.	IDA	Component
GO:0071786	endoplasmic reticulum tubular network organization	18779370.26906412.	IMP	Process
GO:0071787	endoplasmic reticulum tubular network formation	24262037.25612671.	IDA	Process
GO:0090156	cellular sphingolipid homeostasis	-	IEA	Process
GO:0098826	endoplasmic reticulum tubular network membrane	27619977.	IDA	Component
GO:1905552	positive regulation of protein localization to endoplasmic reticulum	27353365.	IDA	Process
GO:1905580	positive regulation of ERBB3 signaling pathway	27353365.	IMP	Process
GO:1990809	endoplasmic reticulum tubular network membrane organization	27619977.	IMP	Process
GO:2000172	regulation of branching morphogenesis of a nerve	-	ISS	Process

EuRBPDB

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Description

RBPome

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

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Note: to get the extension of tumor abbreviations.