EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
20886430	Reduced expression of the membrane skeleton protein beta1-spectrin (SPTBN1) is associated with worsened prognosis in pancreatic cancer.	Histol Histopathol	2010 Dec	Jiang X	doi: 10.14670/HH-25.1497.
27496196	Lung adenocarcinoma harboring concomitant SPTBN1-ALK fusion, c-Met overexpression, and HER-2 amplification with inherent resistance to crizotinib, chemotherapy, and radiotherapy.	J Hematol Oncol	2016 Aug 5	Gu FF	doi: 10.1186/s13045-016-0296-8.

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr2	54629332	Missense_Mutation	NA	S733L	0.19
BLCA	chr2	54655081	Missense_Mutation	NA	S1945C	0.41
BLCA	chr2	54629249	Silent	rs573614306	I705I	0.18
BLCA	chr2	54655920	Nonsense_Mutation	NA	E1990*	0.29
BLCA	chr2	54629054	Silent	NA	L640L	0.22
BLCA	chr2	54621434	Silent	NA	I266I	0.3
BLCA	chr2	54655947	Missense_Mutation	novel	R1999W	0.14
BLCA	chr2	54529777	Intron	novel		0.35
BLCA	chr2	54643049	Missense_Mutation	NA	L1309V	0.16
BLCA	chr2	54599190	Nonsense_Mutation	novel	R83*	0.42
BLCA	chr2	54653773	Silent	novel	F1914F	0.42
BLCA	chr2	54668408	Missense_Mutation	rs540132022	E2312K	0.14
BLCA	chr2	54629594	Silent	novel	V820V	0.28
BLCA	chr2	54631532	Frame_Shift_Del	novel	*N1163Sfs23**	0.4
BLCA	chr2	54649857	Silent	NA	K1815K	0.17
BLCA	chr2	54632729	Nonsense_Mutation	novel	S1243*	0.53
BLCA	chr2	54616284	Silent	rs374090816	Q184Q	0.16
BLCA	chr2	54526418	5'UTR	novel		0.48
BLCA	chr2	54629977	Missense_Mutation	novel	G919R	0.29
BLCA	chr2	54629332	Missense_Mutation	NA	S733L	0.24
BLCA	chr2	54645259	Missense_Mutation	novel	K1434E	0.07
BLCA	chr2	54666052	Missense_Mutation	novel	L2266P	0.11
BLCA	chr2	54668474	Missense_Mutation	NA	V2334L	0.48
BLCA	chr2	54631410	Missense_Mutation	NA	M1121I	0.37
BLCA	chr2	54647160	Silent	NA	K1632K	0.23
BLCA	chr2	54664498	Nonsense_Mutation	novel	E2156*	0.27
BLCA	chr2	54655148	Silent	NA	F1967F	0.17
BLCA	chr2	54632665	Missense_Mutation	novel	E1222Q	0.28
BLCA	chr2	54612217	Frame_Shift_Del	novel	*L120Sfs3**	0.22
BLCA	chr2	54618082	Missense_Mutation	novel	D218H	0.09
BRCA	chr2	54624946	Missense_Mutation	NA	Q442P	0.38
BRCA	chr2	54632750	Missense_Mutation	NA	V1250G	0.13
BRCA	chr2	54529618	Intron	novel		0.36
BRCA	chr2	54558687	Intron	novel		0.71
BRCA	chr2	54632681	Missense_Mutation	NA	A1227G	0.85
BRCA	chr2	54625937	Silent	novel	N449N	0.06
BRCA	chr2	54664463	Missense_Mutation	novel	T2144M	0.28
BRCA	chr2	54647139	Silent	NA	Q1625Q	0.16
BRCA	chr2	54629750	Silent	rs778526430	L872L	0.2
BRCA	chr2	54526542	Missense_Mutation	NA	R42W	0.28
BRCA	chr2	54558693	Intron	novel		0.13
BRCA	chr2	54644376	Silent	novel	E1353E	0.16
BRCA	chr2	54631389	Silent	NA	Y1114Y	0.17
BRCA	chr2	54643037	Nonsense_Mutation	NA	E1305*	0.12
BRCA	chr2	54637731	Silent	novel	E1262E	0.15
BRCA	chr2	54660092	Intron	novel		0.19
BRCA	chr2	54655078	Missense_Mutation	novel	S1944L	0.08
BRCA	chr2	54631227	Missense_Mutation	NA	E1060D	0.29
BRCA	chr2	54647200	Missense_Mutation	NA	E1646K	0.22
CESC	chr2	54668713	3'UTR	novel		0.21
CESC	chr2	54618148	Missense_Mutation	rs752488873	L240V	0.18
CESC	chr2	54644464	Missense_Mutation	NA	E1383K	0.19
CESC	chr2	54646235	Silent	rs370830282	D1542D	0.18
CESC	chr2	54626040	Missense_Mutation	novel	V484M	0.08
CESC	chr2	54529800	Intron	novel		0.17
CESC	chr2	54647188	Missense_Mutation	NA	E1642K	0.57
CESC	chr2	54621466	Missense_Mutation	novel	F277S	0.1
CESC	chr2	54629203	Missense_Mutation	novel	R690H	0.24
CESC	chr2	54629780	Missense_Mutation	novel	E882D	0.32
CESC	chr2	54644462	Missense_Mutation	novel	A1382V	0.36
CESC	chr2	54666078	Missense_Mutation	novel	F2275I	0.19
CESC	chr2	54637729	Missense_Mutation	NA	E1262Q	0.26
CESC	chr2	54529588	Intron	novel		0.56
CESC	chr2	54529726	Intron	novel		0.72
CESC	chr2	54665921	Nonsense_Mutation	novel	W2222*	0.08
CESC	chr2	54667603	Splice_Site	NA	X2278_splice	0.16
CESC	chr2	54632655	Missense_Mutation	novel	M1218I	0.08
CESC	chr2	54669428	3'UTR	novel		0.18
CESC	chr2	54631051	Missense_Mutation	NA	E1002K	0.31
CESC	chr2	54645226	Splice_Region	novel		0.33
CHOL	chr2	54629947	Missense_Mutation	novel	N909D	0.5
CHOL	chr2	54631253	Missense_Mutation	novel	R1069L	0.2
COAD	chr2	54626204	Silent	rs761984098	L538L	0.26
COAD	chr2	54645965	Missense_Mutation	rs746665381	T1511M	0.32
COAD	chr2	54558870	Intron	NA		0.39
COAD	chr2	54631104	Silent	rs768214982	A1019A	0.45
COAD	chr2	54668451	Missense_Mutation	rs748736138	A2326V	0.28
COAD	chr2	54631237	Missense_Mutation	NA	L1064V	0.21
COAD	chr2	54624847	Missense_Mutation	NA	A409V	0.14
COAD	chr2	54617687	Missense_Mutation	NA	R216W	0.18
COAD	chr2	54643062	Nonsense_Mutation	NA	W1313*	0.32
COAD	chr2	54644525	Missense_Mutation	novel	I1403T	0.08
COAD	chr2	54629766	Missense_Mutation	novel	P878S	0.21
COAD	chr2	54649737	Silent	NA	T1775T	0.36
COAD	chr2	54629199	Missense_Mutation	NA	G689S	0.2
COAD	chr2	54622355	Missense_Mutation	NA	A311V	0.17
COAD	chr2	54629032	Missense_Mutation	rs752181604	R633H	0.28
COAD	chr2	54653613	Missense_Mutation	NA	R1861M	0.46
COAD	chr2	54644509	Missense_Mutation	rs754643448	G1398S	0.05
COAD	chr2	54657961	Missense_Mutation	NA	E2053A	0.3
COAD	chr2	54629488	Missense_Mutation	NA	K785R	0.31
COAD	chr2	54649850	Missense_Mutation	NA	D1813G	0.75
COAD	chr2	54659997	Missense_Mutation	NA	R2140W	0.26
COAD	chr2	54526568	Splice_Site	NA	X50_splice	0.39
COAD	chr2	54622467	Silent	NA	R348R	0.3
COAD	chr2	54612290	Missense_Mutation	NA	R144W	0.05
COAD	chr2	54646239	Missense_Mutation	novel	I1544V	0.18
COAD	chr2	54668499	Missense_Mutation	novel	P2342L	0.16
COAD	chr2	54649645	Nonsense_Mutation	NA	R1745*	0.25
COAD	chr2	54626095	Frame_Shift_Del	novel	*K503Rfs24**	0.06
COAD	chr2	54629504	Silent	NA	A790A	0.17
COAD	chr2	54526432	Missense_Mutation	novel	V5A	0.1
COAD	chr2	54645346	Missense_Mutation	rs201812651	V1463M	0.12
COAD	chr2	54626226	Nonsense_Mutation	novel	E546*	0.31
COAD	chr2	54616235	Missense_Mutation	NA	D168G	0.1
COAD	chr2	54664682	Missense_Mutation	novel	A2217V	0.18
COAD	chr2	54645355	Missense_Mutation	NA	K1466E	0.46
COAD	chr2	54621467	Missense_Mutation	NA	F277L	0.26
COAD	chr2	54626007	Missense_Mutation	rs752434436	A473T	0.4
COAD	chr2	54653669	Missense_Mutation	rs375121259	D1880N	0.42
COAD	chr2	54668385	Missense_Mutation	NA	S2304F	0.19
COAD	chr2	54629649	Missense_Mutation	rs749069838	R839W	0.41
COAD	chr2	54659969	Silent	rs145150707	N2130N	0.3
COAD	chr2	54653604	Splice_Region	NA		0.28
COAD	chr2	54558690	Intron	novel		0.15
COAD	chr2	54668471	Missense_Mutation	rs772551816	V2333I	0.11
COAD	chr2	54631534	Missense_Mutation	NA	N1163H	0.15
COAD	chr2	54664490	Missense_Mutation	NA	G2153D	0.21
COAD	chr2	54629741	In_Frame_Ins	novel	E869_Q870insT	0.15
COAD	chr2	54649870	Missense_Mutation	NA	R1820C	0.16
COAD	chr2	54668433	Missense_Mutation	rs112558321	T2320M	0.12
ESCA	chr2	54657887	Silent	rs200669658	V2028V	0.2
ESCA	chr2	54664622	Missense_Mutation	rs781460543	S2197L	0.27
GBM	chr2	54629582	Silent	NA	E816E	0.41
GBM	chr2	54645258	Missense_Mutation	novel	K1433N	0.19
GBM	chr2	54558607	Intron	novel		0.17
GBM	chr2	54668358	Missense_Mutation	novel	M2295T	0.06
GBM	chr2	54631390	Missense_Mutation	rs765438423	E1115K	0.26
GBM	chr2	54645267	Silent	rs773794373	I1436I	0.22
GBM	chr2	54668389	Silent	novel	A2305A	0.34
GBM	chr2	54645936	Silent	novel	V1501V	0.09
GBM	chr2	54646289	Frame_Shift_Del	novel	*E1561Rfs10**	0.07
GBM	chr2	54526482	Missense_Mutation	novel	N22H	0.12
GBM	chr2	54526484	Missense_Mutation	novel	N22K	0.1
GBM	chr2	54629022	Missense_Mutation	NA	R630C	0.43
GBM	chr2	54630021	Silent	NA	L933L	0.39
GBM	chr2	54631273	Missense_Mutation	novel	S1076P	0.5
GBM	chr2	54643068	Missense_Mutation	novel	K1315T	0.05
GBM	chr2	54624949	Missense_Mutation	rs772259760	R443H	0.27
GBM	chr2	54660109	Intron	novel		0.1
HNSC	chr2	54664466	Missense_Mutation	novel	V2145G	0.15
HNSC	chr2	54629082	Missense_Mutation	novel	E650Q	0.17
HNSC	chr2	54632635	Missense_Mutation	novel	E1212Q	0.11
HNSC	chr2	54629547	Nonsense_Mutation	novel	E805*	0.24
HNSC	chr2	54649161	Missense_Mutation	novel	E1725K	0.13
HNSC	chr2	54526549	Missense_Mutation	novel	R44L	0.24
HNSC	chr2	54629034	Missense_Mutation	novel	L634M	0.31
HNSC	chr2	54526530	Missense_Mutation	NA	R38W	0.17
HNSC	chr2	54630873	Silent	novel	E942E	0.21
HNSC	chr2	54629747	Nonsense_Mutation	novel	W871*	0.15
HNSC	chr2	54632609	Missense_Mutation	novel	G1203E	0.06
HNSC	chr2	54645300	Missense_Mutation	novel	S1447R	0.05
HNSC	chr2	54617622	Missense_Mutation	rs754107495	N194S	0.3
HNSC	chr2	54629019	Nonsense_Mutation	novel	E629*	0.28
HNSC	chr2	54622355	Missense_Mutation	NA	A311V	0.09
HNSC	chr2	54622378	Missense_Mutation	novel	E319Q	0.11
HNSC	chr2	54628951	Missense_Mutation	novel	P606H	0.19
HNSC	chr2	54664540	Missense_Mutation	rs202001000	P2170S	0.27
KIRC	chr2	54643072	Silent	NA	H1316H	0.31
KIRC	chr2	54655971	Nonsense_Mutation	NA	E2007*	0.22
KIRC	chr2	54631208	Frame_Shift_Del	novel	*E1055Gfs20**	0.19
KIRC	chr2	54626054	In_Frame_Ins	novel	L488_E489insML	0.07
KIRC	chr2	54664647	Missense_Mutation	NA	N2205K	0.24
KIRP	chr2	54624863	Silent	rs756836467	L414L	0.18
KIRP	chr2	54657857	Frame_Shift_Del	novel	*V2019Sfs27**	0.48
KIRP	chr2	54646282	Missense_Mutation	novel	L1558R	0.06
KIRP	chr2	54647249	Missense_Mutation	novel	S1662T	0.45
KIRP	chr2	54612245	Frame_Shift_Del	novel	*L130Gfs4**	0.74
LAML	chr2	54629043	Missense_Mutation	novel	S637P	0.28
LAML	chr2	54649729	Missense_Mutation	novel	A1773T	0.28
LAML	chr2	54631440	Silent	novel	G1131G	0.12
LGG	chr2	54632720	Missense_Mutation	NA	N1240S	0.06
LGG	chr2	54653806	Silent	NA	L1925L	0.38
LGG	chr2	54618118	Missense_Mutation	rs760099132	A230T	0.21
LGG	chr2	54622466	Missense_Mutation	rs748951777	R348H	0.32
LGG	chr2	54631161	Silent	rs747395779	A1038A	0.35
LGG	chr2	54647206	Missense_Mutation	novel	V1648M	0.13
LGG	chr2	54657878	Silent	rs144327595	D2025D	0.31
LGG	chr2	54659249	Silent	rs372899977	A2113A	0.43
LIHC	chr2	54631030	Nonsense_Mutation	novel	Q995*	0.35
LIHC	chr2	54632682	Silent	NA	A1227A	0.39
LIHC	chr2	54646003	Missense_Mutation	novel	I1524V	0.39
LIHC	chr2	54647198	Missense_Mutation	NA	A1645E	0.44
LIHC	chr2	54631376	Missense_Mutation	novel	E1110V	0.4
LIHC	chr2	54643047	Missense_Mutation	novel	N1308S	0.19
LIHC	chr2	54649760	Missense_Mutation	NA	L1783R	0.31
LIHC	chr2	54526512	Missense_Mutation	NA	N32Y	0.5
LIHC	chr2	54626055	Missense_Mutation	NA	E489K	0.39
LIHC	chr2	54558863	Intron	novel		0.29
LIHC	chr2	54655079	Silent	NA	S1944S	0.4
LIHC	chr2	54664520	Missense_Mutation	novel	E2163V	0.29
LIHC	chr2	54628234	Missense_Mutation	novel	F594L	0.1
LIHC	chr2	54631364	Missense_Mutation	rs772780138	N1106S	0.31
LIHC	chr2	54632660	Missense_Mutation	NA	A1220V	0.39
LIHC	chr2	54630000	Silent	NA	I926I	0.65
LUAD	chr2	54645321	Silent	rs540844973	D1454D	0.18
LUAD	chr2	54649032	Missense_Mutation	novel	G1682S	0.45
LUAD	chr2	54644440	Missense_Mutation	novel	R1375W	0.05
LUAD	chr2	54653565	Intron	novel		0.55
LUAD	chr2	54646410	Missense_Mutation	novel	A1601P	0.21
LUAD	chr2	54648990	Missense_Mutation	rs760684638	R1668C	0.24
LUAD	chr2	54668632	3'UTR	novel		0.38
LUAD	chr2	54644463	Silent	rs775402962	A1382A	0.15
LUAD	chr2	54616244	Missense_Mutation	novel	E171G	0.18
LUAD	chr2	54624870	Nonsense_Mutation	NA	Q417*	0.45
LUAD	chr2	54630984	Missense_Mutation	NA	E979D	0.5
LUAD	chr2	54655978	Missense_Mutation	rs762333666	R2009Q	0.22
LUAD	chr2	54668435	Frame_Shift_Del	novel	*P2321Ifs58**	0.08
LUAD	chr2	54629280	Missense_Mutation	rs750448290	R716C	0.14
LUAD	chr2	54599168	In_Frame_Del	novel	Y79_L82del	0.13
LUAD	chr2	54526409	5'UTR	novel		0.19
LUAD	chr2	54646273	Missense_Mutation	NA	S1555T	0.19
LUAD	chr2	54668577	3'UTR	novel		0.22
LUAD	chr2	54628231	Missense_Mutation	novel	K593N	0.37
LUAD	chr2	54631174	Missense_Mutation	novel	V1043L	0.05
LUAD	chr2	54653699	Silent	rs369227418	L1890L	0.29
LUAD	chr2	54626111	Silent	rs374624032	I507I	0.05
LUAD	chr2	54629056	Nonsense_Mutation	novel	W641*	0.08
LUAD	chr2	54666045	Missense_Mutation	NA	V2264L	0.13
LUAD	chr2	54630991	Nonsense_Mutation	NA	Q982*	0.21
LUAD	chr2	54632727	Missense_Mutation	NA	N1242K	0.48
LUAD	chr2	54647231	Missense_Mutation	rs779152792	R1656Q	0.11
LUAD	chr2	54630974	Missense_Mutation	novel	K976R	0.52
LUAD	chr2	54645255	Silent	NA	R1432R	0.16
LUAD	chr2	54653795	Missense_Mutation	NA	D1922N	0.2
LUAD	chr2	54645355	Nonsense_Mutation	novel	K1466*	0.38
LUAD	chr2	54623565	Missense_Mutation	novel	R384L	0.06
LUAD	chr2	54645295	Silent	NA	L1446L	0.18
LUAD	chr2	54617646	Missense_Mutation	novel	W202L	0.62
LUAD	chr2	54624871	Missense_Mutation	novel	Q417P	0.17
LUAD	chr2	54626185	Missense_Mutation	novel	K532T	0.39
LUAD	chr2	54631475	Missense_Mutation	novel	R1143L	0.24
LUAD	chr2	54653656	Silent	novel	A1875A	0.43
LUSC	chr2	54649192	Splice_Site	NA	X1734_splice	0.21
LUSC	chr2	54655099	Missense_Mutation	NA	N1951S	0.52
LUSC	chr2	54526531	Missense_Mutation	novel	R38L	0.23
LUSC	chr2	54649116	Missense_Mutation	novel	L1710M	0.3
LUSC	chr2	54629397	Missense_Mutation	novel	D755H	0.13
LUSC	chr2	54644327	Missense_Mutation	novel	G1337V	0.16
LUSC	chr2	54629957	Missense_Mutation	novel	A912V	0.13
LUSC	chr2	54646228	Missense_Mutation	NA	R1540H	0.19
LUSC	chr2	54646200	Nonsense_Mutation	novel	Q1531*	0.33
LUSC	chr2	54664529	Missense_Mutation	novel	P2166L	0.28
LUSC	chr2	54629272	Missense_Mutation	novel	E713A	0.29
LUSC	chr2	54668550	Missense_Mutation	novel	L2359P	0.08
LUSC	chr2	54629206	Missense_Mutation	novel	S691T	0.12
LUSC	chr2	54629567	Silent	NA	P811P	0.14
LUSC	chr2	54626039	Silent	rs537029257	A483A	0.38
LUSC	chr2	54529445	Intron	novel		0.13
LUSC	chr2	54664693	Splice_Region	novel		0.11
LUSC	chr2	54629177	Silent	NA	R681R	0.23
LUSC	chr2	54626175	Missense_Mutation	novel	G529W	0.23
LUSC	chr2	54629485	Missense_Mutation	NA	K784M	0.25
LUSC	chr2	54629355	Missense_Mutation	NA	E741Q	0.03
LUSC	chr2	54632598	Silent	NA	T1199T	0.68
LUSC	chr2	54631524	Silent	novel	E1159E	0.36
LUSC	chr2	54612254	Missense_Mutation	novel	N132H	0.16
LUSC	chr2	54664629	Silent	novel	Q2199Q	0.34
LUSC	chr2	54664556	Missense_Mutation	novel	K2175T	0.13
LUSC	chr2	54626158	Missense_Mutation	novel	R523L	0.35
LUSC	chr2	54631602	Silent	novel	L1185L	0.24
LUSC	chr2	54664588	Missense_Mutation	rs200361368	A2186T	0.25
LUSC	chr2	54647199	Silent	rs145221949	A1645A	0.29
LUSC	chr2	54649179	Missense_Mutation	novel	E1731Q	0.27
LUSC	chr2	54529547	Intron	novel		0.11
LUSC	chr2	54599230	Missense_Mutation	novel	S96F	0.09
LUSC	chr2	54665977	Missense_Mutation	NA	K2241T	0.14
MESO	chr2	54630927	Silent	novel	Y960Y	0.17
MESO	chr2	54649717	Missense_Mutation	novel	G1769R	0.15
OV	chr2	54668389	Silent	novel	A2305A	0.16
OV	chr2	54649014	Missense_Mutation	novel	V1676M	0.09
OV	chr2	54558819	Intron	novel		0.05
OV	chr2	54558837	Intron	NA		0.34
OV	chr2	54643063	Missense_Mutation	novel	W1313C	0.09
OV	chr2	54631300	Missense_Mutation	novel	I1085L	0.22
OV	chr2	54653496	Intron	novel		0.09
OV	chr2	54655191	Missense_Mutation	novel	H1982N	0.04
OV	chr2	54529380	Intron	rs776566561		0.34
OV	chr2	54668533	Missense_Mutation	novel	K2353N	0.05
OV	chr2	54630931	Missense_Mutation	NA	L962F	0.24
OV	chr2	54649720	Missense_Mutation	novel	H1770Y	0.39
OV	chr2	54616224	Silent	novel	V164V	0.18
OV	chr2	54647142	Silent	novel	S1626S	0.06
OV	chr2	54629959	Missense_Mutation	rs759737447	R913C	0.36
OV	chr2	54629764	Missense_Mutation	novel	I877T	0.18
OV	chr2	54649872	In_Frame_Ins	novel	R1820_I1821insHLVCPSFSL	0.06
OV	chr2	54629760	Nonsense_Mutation	novel	Q876*	0.13
OV	chr2	54645337	Missense_Mutation	novel	R1460C	0.05
PAAD	chr2	54628167	Missense_Mutation	novel	L572R	0.39
PAAD	chr2	54526525	Missense_Mutation	novel	S36F	0.16
PAAD	chr2	54629514	Missense_Mutation	rs751609029	A794T	0.17
PAAD	chr2	54647190	Missense_Mutation	rs764862001	E1642D	0.18
PAAD	chr2	54526544	Silent	novel	R42R	0.21
PRAD	chr2	54629692	Missense_Mutation	rs767166000	K853R	0.1
PRAD	chr2	54529740	Intron	novel		0.13
PRAD	chr2	54659231	Silent	rs150684675	T2107T	0.15
PRAD	chr2	54526529	Silent	NA	A37A	0.22
PRAD	chr2	54649627	Nonsense_Mutation	NA	R1739*	0.16
PRAD	chr2	54655193	Missense_Mutation	NA	H1982Q	0.39
PRAD	chr2	54621430	Missense_Mutation	novel	S265F	0.38
PRAD	chr2	54629457	Missense_Mutation	rs1804471	D775N	0.62
PRAD	chr2	54631033	Missense_Mutation	novel	R996C	0.33
PRAD	chr2	54668403	Missense_Mutation	NA	K2310R	0.29
READ	chr2	54558559	Intron	novel		0.3
READ	chr2	54558667	Intron	novel		0.45
READ	chr2	54646206	Nonsense_Mutation	novel	E1533*	0.39
READ	chr2	54631313	Missense_Mutation	novel	D1089V	0.45
READ	chr2	54629476	Missense_Mutation	novel	S781F	0.22
READ	chr2	54637731	Silent	novel	E1262E	0.06
SARC	chr2	54612331	Silent	novel	F157F	0.09
SARC	chr2	54668713	3'UTR	novel		0.14
SARC	chr2	54628243	Silent	rs551964268	D597D	0.34
SKCM	chr2	54645254	Missense_Mutation	novel	R1432Q	0.46
SKCM	chr2	54645255	Silent	novel	R1432R	0.45
SKCM	chr2	54646195	Missense_Mutation	novel	T1529I	0.39
SKCM	chr2	54664602	Silent	NA	A2190A	0.43
SKCM	chr2	54558807	Intron	novel		0.43
SKCM	chr2	54653716	Silent	novel	S1895S	0.31
SKCM	chr2	54623478	Splice_Site	novel	X355_splice	0.36
SKCM	chr2	54558807	Intron	novel		0.44
SKCM	chr2	54529466	Intron	NA		0.08
SKCM	chr2	54629127	Missense_Mutation	novel	D665N	0.29
SKCM	chr2	54629114	Silent	NA	I660I	0.3
SKCM	chr2	54629435	Silent	rs751662280	V767V	0.26
SKCM	chr2	54660195	Intron	novel		0.46
SKCM	chr2	54631043	Missense_Mutation	NA	T999I	0.38
SKCM	chr2	54645962	Missense_Mutation	novel	S1510F	0.31
SKCM	chr2	54664509	Silent	rs758704866	T2159T	0.17
SKCM	chr2	54631482	Silent	NA	Q1145Q	0.16
SKCM	chr2	54526461	Nonsense_Mutation	NA	Q15*	0.3
SKCM	chr2	54631137	Silent	NA	A1030A	0.37
SKCM	chr2	54624906	Missense_Mutation	NA	R429C	0.21
SKCM	chr2	54529495	Intron	NA		0.15
SKCM	chr2	54657929	Silent	NA	S2042S	0.37
SKCM	chr2	54668473	Silent	rs199584027	V2333V	0.26
SKCM	chr2	54653774	Missense_Mutation	NA	R1915C	0.24
SKCM	chr2	54631217	Missense_Mutation	NA	S1057F	0.27
SKCM	chr2	54645420	Silent	rs766964964	I1487I	0.24
SKCM	chr2	54628961	Silent	rs778327408	I609I	0.46
SKCM	chr2	54629345	Silent	NA	K737K	0.37
SKCM	chr2	54645963	Silent	NA	S1510S	0.25
SKCM	chr2	54529465	Intron	NA		0.18
SKCM	chr2	54618181	Silent	NA	L251L	0.3
SKCM	chr2	54649148	Silent	rs368730014	V1720V	0.13
SKCM	chr2	54649174	Missense_Mutation	novel	D1729V	0.39
SKCM	chr2	54624834	Missense_Mutation	NA	E405K	0.38
SKCM	chr2	54626112	Missense_Mutation	rs144666036	R508W	0.26
SKCM	chr2	54653707	Silent	NA	A1892A	0.12
STAD	chr2	54631333	Frame_Shift_Del	novel	*E1098Afs86**	0.22
STAD	chr2	54629198	Silent	rs749471660	S688S	0.11
STAD	chr2	54631362	Silent	novel	E1105E	0.18
STAD	chr2	54529518	Intron	novel		0.35
STAD	chr2	54646228	Missense_Mutation	NA	R1540H	0.14
STAD	chr2	54653610	Missense_Mutation	NA	V1860G	0.38
STAD	chr2	54649967	Missense_Mutation	NA	D1852V	0.13
STAD	chr2	54649675	Missense_Mutation	rs779986830	V1755M	0.17
STAD	chr2	54668558	Frame_Shift_Del	novel	*K2363Rfs59**	0.38
STAD	chr2	54626211	Missense_Mutation	rs200538825	M541V	0.57
STAD	chr2	54612185	Missense_Mutation	NA	R109C	0.08
STAD	chr2	54628243	Silent	rs551964268	D597D	0.18
STAD	chr2	54668386	Silent	rs147084588	S2304S	0.21
STAD	chr2	54612262	Silent	rs765480147	G134G	0.31
STAD	chr2	54630913	Missense_Mutation	NA	S956G	0.33
STAD	chr2	54657879	Missense_Mutation	rs760421103	A2026T	0.26
STAD	chr2	54529394	Intron	novel		0.52
STAD	chr2	54653683	Silent	novel	K1884K	0.32
STAD	chr2	54655978	Missense_Mutation	rs762333666	R2009Q	0.44
STAD	chr2	54666041	Silent	rs773456466	C2262C	0.38
STAD	chr2	54649633	Missense_Mutation	rs750537630	R1741W	0.26
STAD	chr2	54649673	Missense_Mutation	novel	R1754H	0.28
STAD	chr2	54622364	Missense_Mutation	novel	L314P	0.1
STAD	chr2	54629014	Missense_Mutation	rs557616559	A627V	0.29
STAD	chr2	54668388	Missense_Mutation	novel	A2305V	0.35
STAD	chr2	54637744	Frame_Shift_Del	novel	*L1267Ffs2**	0.26
STAD	chr2	54629202	Missense_Mutation	novel	R690C	0.41
STAD	chr2	54629200	Missense_Mutation	NA	G689D	0.2
STAD	chr2	54668449	Silent	rs779397892	R2325R	0.11
STAD	chr2	54645356	Missense_Mutation	NA	K1466T	0.09
STAD	chr2	54629622	Missense_Mutation	NA	R830W	0.38
STAD	chr2	54632739	Missense_Mutation	novel	I1246M	0.31
STAD	chr2	54631045	Missense_Mutation	NA	G1000S	0.21
STAD	chr2	54624824	Missense_Mutation	NA	K401N	0.24
STAD	chr2	54647244	Silent	rs748639736	A1660A	0.19
STAD	chr2	54625983	Missense_Mutation	NA	E465K	0.37
STAD	chr2	54631198	Missense_Mutation	NA	L1051M	0.35
STAD	chr2	54643052	Missense_Mutation	NA	H1310Y	0.41
STAD	chr2	54629132	Silent	rs773513812	Y666Y	0.07
STAD	chr2	54668473	Silent	rs199584027	V2333V	0.25
STAD	chr2	54646228	Missense_Mutation	NA	R1540H	0.18
STAD	chr2	54660139	Intron	novel		0.32
STAD	chr2	54631119	Silent	NA	S1024S	0.38
TGCT	chr2	54660088	Intron	novel		0.17
TGCT	chr2	54558778	Intron	novel		0.21
THCA	chr2	54629591	Missense_Mutation	NA	D819E	0.38
UCEC	chr2	54626083	Missense_Mutation	NA	R498H	0.49
UCEC	chr2	54630903	Silent	NA	L952L	0.38
UCEC	chr2	54631252	Missense_Mutation	NA	R1069W	0.55
UCEC	chr2	54645346	Missense_Mutation	rs201812651	V1463M	0.52
UCEC	chr2	54646228	Missense_Mutation	NA	R1540H	0.34
UCEC	chr2	54660057	Intron	novel		0.09
UCEC	chr2	54653833	Silent	rs781563729	I1934I	0.29
UCEC	chr2	54628234	Silent	rs761403914	F594F	0.3
UCEC	chr2	54631562	Missense_Mutation	NA	Q1172R	0.27
UCEC	chr2	54649849	Missense_Mutation	rs765879123	D1813N	0.16
UCEC	chr2	54526489	Missense_Mutation	rs779865142	R24H	0.37
UCEC	chr2	54621502	Missense_Mutation	novel	R289Q	0.18
UCEC	chr2	54628146	Missense_Mutation	novel	D565G	0.16
UCEC	chr2	54629024	Silent	rs750788374	R630R	0.3
UCEC	chr2	54631253	Missense_Mutation	novel	R1069Q	0.39
UCEC	chr2	54632735	Missense_Mutation	novel	R1245H	0.11
UCEC	chr2	54637784	Missense_Mutation	novel	F1280S	0.23
UCEC	chr2	54669434	3'UTR	novel		0.08
UCEC	chr2	54558867	Intron	novel		0.42
UCEC	chr2	54618185	Missense_Mutation	novel	D252G	0.06
UCEC	chr2	54625973	Silent	novel	T461T	0.5
UCEC	chr2	54630915	Silent	rs756323111	S956S	0.38
UCEC	chr2	54661496	Intron	novel		0.06
UCEC	chr2	54637717	Missense_Mutation	NA	R1258G	0.5
UCEC	chr2	54617673	Missense_Mutation	novel	L211P	0.19
UCEC	chr2	54629076	Missense_Mutation	novel	A648T	0.11
UCEC	chr2	54623542	Silent	novel	N376N	0.51
UCEC	chr2	54621502	Missense_Mutation	novel	R289Q	0.38
UCEC	chr2	54631298	Missense_Mutation	rs377200533	A1084V	0.47
UCEC	chr2	54661609	Intron	novel		0.06
UCEC	chr2	54668712	3'UTR	rs541933368		0.27
UCEC	chr2	54526440	Missense_Mutation	novel	D8Y	0.38
UCEC	chr2	54631298	Missense_Mutation	rs377200533	A1084V	0.47
UCEC	chr2	54653792	Missense_Mutation	novel	R1921C	0.41
UCEC	chr2	54669647	3'UTR	novel		0.3
UCEC	chr2	54653725	Silent	rs771299659	D1898D	0.56
UCEC	chr2	54649688	Missense_Mutation	novel	N1759T	0.3
UCEC	chr2	54648991	Missense_Mutation	novel	R1668H	0.05
UCEC	chr2	54628178	Missense_Mutation	novel	D576N	0.08
UCEC	chr2	54629270	Silent	rs146810411	S712S	0.23
UCEC	chr2	54645322	Missense_Mutation	NA	E1455K	0.19
UCEC	chr2	54647137	Nonsense_Mutation	NA	Q1625*	0.23
UCEC	chr2	54649813	Missense_Mutation	NA	L1801I	0.18
UCEC	chr2	54653775	Missense_Mutation	NA	R1915H	0.2
UCEC	chr2	54668518	Silent	NA	D2348D	0.16
UCEC	chr2	54617687	Missense_Mutation	NA	R216W	0.08
UCEC	chr2	54625983	Missense_Mutation	NA	E465K	0.08
UCEC	chr2	54629976	Silent	NA	S918S	0.29
UCEC	chr2	54629457	Missense_Mutation	rs1804471	D775N	0.25
UCEC	chr2	54645357	Missense_Mutation	novel	K1466N	0.17
UCEC	chr2	54646442	Missense_Mutation	novel	Q1611H	0.29
UCEC	chr2	54659205	Missense_Mutation	rs778160145	R2099W	0.33
UCEC	chr2	54667644	Missense_Mutation	novel	D2292N	0.4
UCEC	chr2	54668712	3'UTR	rs541933368		0.46
UCEC	chr2	54626038	Missense_Mutation	novel	A483V	0.06
UCEC	chr2	54629271	Missense_Mutation	NA	E713K	0.31
UCEC	chr2	54649943	Missense_Mutation	novel	R1844I	0.72
UCEC	chr2	54668713	3'UTR	novel		0.43
UCEC	chr2	54612208	Silent	novel	V116V	0.29
UCEC	chr2	54664624	Missense_Mutation	rs780273707	A2198S	0.23
UCEC	chr2	54664625	Missense_Mutation	novel	A2198V	0.24
UCEC	chr2	54626073	Missense_Mutation	novel	D495N	0.63
UCEC	chr2	54631389	Silent	NA	Y1114Y	0.41
UCEC	chr2	54669475	3'UTR	rs9134		0.41
UCEC	chr2	54529800	Intron	novel		0.13
UCEC	chr2	54668699	3'UTR	novel		0.4
UCEC	chr2	54558638	Intron	novel		0.31
UCEC	chr2	54666074	Silent	novel	H2273H	0.28
UCEC	chr2	54669680	3'Flank	novel		0.4
UCEC	chr2	54631378	Missense_Mutation	novel	I1111F	0.29
UCEC	chr2	54668712	3'UTR	rs541933368		0.13
UCEC	chr2	54628137	Missense_Mutation	rs753086001	G562D	0.48
UCEC	chr2	54629023	Missense_Mutation	novel	R630H	0.33
UCEC	chr2	54631174	Missense_Mutation	rs768447926	V1043M	0.28
UCEC	chr2	54668557	Frame_Shift_Ins	novel	*K2364Efs17**	0.21
UCEC	chr2	54669413	3'UTR	novel		0.36
UCEC	chr2	54661626	Intron	novel		0.37
UCEC	chr2	54668713	3'UTR	novel		0.37
UCEC	chr2	54649032	Missense_Mutation	novel	G1682S	0.27
UCEC	chr2	54526531	Missense_Mutation	novel	R38Q	0.4
UCEC	chr2	54631262	Missense_Mutation	novel	D1072G	0.26
UCEC	chr2	54632723	Missense_Mutation	novel	I1241T	0.32
UCEC	chr2	54612253	Missense_Mutation	novel	E131D	0.47
UCEC	chr2	54646335	Missense_Mutation	novel	L1576F	0.35
UCEC	chr2	54669376	3'UTR	novel		0.63
UCEC	chr2	54612185	Missense_Mutation	NA	R109C	0.16
UCEC	chr2	54655083	Missense_Mutation	NA	V1946I	0.4
UCEC	chr2	54653393	Intron	novel		0.18
UCEC	chr2	54624804	Missense_Mutation	NA	A395T	0.41
UCEC	chr2	54624830	Missense_Mutation	NA	E403D	0.51
UCEC	chr2	54625982	Silent	rs766385315	H464H	0.37
UCEC	chr2	54643111	Nonsense_Mutation	NA	W1329*	0.35
UCEC	chr2	54646237	Missense_Mutation	NA	D1543G	0.27
UCEC	chr2	54631220	Missense_Mutation	novel	L1058P	0.37
UCEC	chr2	54599190	Nonsense_Mutation	novel	R83*	0.3
UCEC	chr2	54622319	Missense_Mutation	novel	E299G	0.35
UCEC	chr2	54629022	Missense_Mutation	NA	R630C	0.43
UCEC	chr2	54526528	Missense_Mutation	novel	A37V	0.33
UCEC	chr2	54529514	Intron	novel		0.25
UCEC	chr2	54631071	Silent	novel	I1008I	0.28
UCEC	chr2	54645938	Missense_Mutation	novel	G1502E	0.34
UCEC	chr2	54659227	Missense_Mutation	novel	S2106N	0.34
UCEC	chr2	54668411	Missense_Mutation	novel	V2313M	0.18
UCEC	chr2	54645267	Silent	rs773794373	I1436I	0.29
UCEC	chr2	54643033	Silent	rs748501800	Y1303Y	0.34
UCEC	chr2	54645318	Silent	rs145927206	T1453T	0.35
UCEC	chr2	54653637	Missense_Mutation	rs779220012	R1869H	0.42
UCEC	chr2	54659230	Missense_Mutation	rs766647948	T2107M	0.5
UCEC	chr2	54668507	Missense_Mutation	novel	R2345W	0.38
UCEC	chr2	54632659	Missense_Mutation	novel	A1220T	0.45
UCEC	chr2	54646288	Missense_Mutation	novel	A1560D	0.38
UCEC	chr2	54618091	Missense_Mutation	novel	D221Y	0.34
UCEC	chr2	54623491	Missense_Mutation	novel	K359N	0.38
UCEC	chr2	54664488	Silent	rs528849120	N2152N	0.49
UCEC	chr2	54631434	Silent	novel	T1129T	0.25
UCEC	chr2	54625976	Missense_Mutation	novel	K462N	0.45
UCEC	chr2	54629050	Missense_Mutation	NA	R639H	0.47
UCEC	chr2	54629241	Missense_Mutation	novel	D703Y	0.77
UCEC	chr2	54631007	Missense_Mutation	novel	D987A	0.34
UCEC	chr2	54655987	Missense_Mutation	novel	W2012L	0.42
UCEC	chr2	54669451	3'UTR	novel		0.33
UCEC	chr2	54649030	Missense_Mutation	novel	A1681V	0.13
UCEC	chr2	54649160	Silent	novel	H1724H	0.46
UCEC	chr2	54622450	Missense_Mutation	NA	A343T	0.22
UCEC	chr2	54644548	Missense_Mutation	NA	D1411Y	0.31
UCEC	chr2	54646227	Missense_Mutation	novel	R1540C	0.05
UCEC	chr2	54666041	Silent	rs773456466	C2262C	0.2
UCEC	chr2	54668450	Missense_Mutation	rs200348448	A2326T	0.28
UCEC	chr2	54668713	3'UTR	novel		0.3
UCEC	chr2	54628942	Missense_Mutation	novel	P603L	0.37
UCEC	chr2	54631303	Missense_Mutation	novel	A1086T	0.39
UCEC	chr2	54649845	Nonsense_Mutation	novel	Y1811*	0.28
UCEC	chr2	54657967	Missense_Mutation	novel	L2055R	0.15
UCEC	chr2	54624880	Missense_Mutation	novel	L420Q	0.28
UCEC	chr2	54631129	Missense_Mutation	rs545815578	D1028N	0.27
UCEC	chr2	54629519	Missense_Mutation	novel	N795K	0.07
UCEC	chr2	54632659	Missense_Mutation	novel	A1220T	0.08
UCEC	chr2	54645293	Missense_Mutation	NA	A1445V	0.33
UCEC	chr2	54626013	Missense_Mutation	rs747062361	E475K	0.37
UCEC	chr2	54624908	Silent	rs756134030	R429R	0.31
UCEC	chr2	54631423	Missense_Mutation	NA	E1126K	0.1
UCEC	chr2	54632680	Missense_Mutation	novel	A1227T	0.43
UCEC	chr2	54655201	Missense_Mutation	novel	S1985Y	0.32
UCEC	chr2	54661415	Intron	novel		0.33
UCEC	chr2	54646208	Nonsense_Mutation	novel	*I1534Ffs2**	0.07
UCEC	chr2	54631458	Silent	novel	Y1137Y	0.19
UCEC	chr2	54664488	Silent	rs528849120	N2152N	0.33
UCEC	chr2	54622377	Silent	NA	I318I	0.34
UCEC	chr2	54661376	Intron	novel		0.32
UCEC	chr2	54668713	3'UTR	novel		0.42
UCEC	chr2	54612292	Silent	novel	R144R	0.29
UCEC	chr2	54646404	Missense_Mutation	NA	F1599V	0.35
UCEC	chr2	54618108	Missense_Mutation	NA	K226N	0.49
UCEC	chr2	54612269	Missense_Mutation	NA	D137Y	0.46
UCEC	chr2	54616248	Missense_Mutation	novel	K172N	0.05
UCEC	chr2	54618190	Missense_Mutation	NA	E254K	0.38
UCEC	chr2	54624840	Nonsense_Mutation	NA	E407*	0.32
UCEC	chr2	54629397	Missense_Mutation	NA	D755Y	0.25
UCEC	chr2	54669049	3'UTR	novel		0.29
UCEC	chr2	54621417	Missense_Mutation	novel	P261S	0.57
UCEC	chr2	54628190	Missense_Mutation	novel	Q580K	0.2
UCEC	chr2	54629513	Silent	rs267599410	I793I	0.44
UCEC	chr2	54631468	Missense_Mutation	novel	R1141W	0.23
UCEC	chr2	54632697	Silent	rs767198212	G1232G	0.14
UCEC	chr2	54649060	Missense_Mutation	novel	R1691I	0.35
UCEC	chr2	54649858	Missense_Mutation	novel	E1816K	0.19
UCEC	chr2	54664622	Missense_Mutation	rs781460543	S2197L	0.21
UCEC	chr2	54624906	Missense_Mutation	NA	R429C	0.17
UCEC	chr2	54632768	Missense_Mutation	NA	R1256I	0.47
UCEC	chr2	54624803	Splice_Site	NA	X395_splice	0.32
UCEC	chr2	54626114	Silent	NA	R508R	0.22
UCEC	chr2	54643029	Missense_Mutation	NA	S1302F	0.28
UCEC	chr2	54632658	Silent	rs567753600	D1219D	0.46
UCEC	chr2	54666058	Missense_Mutation	novel	Y2268C	0.59
UCEC	chr2	54644506	Missense_Mutation	NA	H1397Y	0.38
UCEC	chr2	54626208	Missense_Mutation	novel	I540V	0.56
UCEC	chr2	54644455	Missense_Mutation	novel	N1380D	0.26
UCEC	chr2	54661463	Intron	novel		0.48
UCEC	chr2	54664552	Missense_Mutation	NA	R2174C	0.45
UCEC	chr2	54623510	Missense_Mutation	novel	L366I	0.4
UCEC	chr2	54626092	Missense_Mutation	rs76198367	A501V	0.2
UCEC	chr2	54630900	Silent	rs757177780	L951L	0.43
UCEC	chr2	54661462	Intron	novel		0.04
UCEC	chr2	54599190	Nonsense_Mutation	novel	R83*	0.38
UCS	chr2	54626073	Missense_Mutation	novel	D495N	0.42
UCS	chr2	54631382	Missense_Mutation	novel	D1112G	0.34
UVM	chr2	54618190	Missense_Mutation	NA	E254K	0.1

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
KIRP	DEL	0.0243	0.08832
PAAD	DEL	0.0707	0.2014

Survival Analysis

Cancer	P-value	Q-value
ACC	0.0026	Kaplan-Meier Survival Analysis
KIRP	0.0068	Kaplan-Meier Survival Analysis
PAAD	0.0024	Kaplan-Meier Survival Analysis
BLCA	0.022	Kaplan-Meier Survival Analysis
CESC	0.0031	Kaplan-Meier Survival Analysis
READ	0.002	Kaplan-Meier Survival Analysis
CHOL	0.044	Kaplan-Meier Survival Analysis
THCA	0.024	Kaplan-Meier Survival Analysis
UVM	0.0033	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Phenotype

GWAS

PPI

Ortholog

Gene Ontology

Description

Ensembl ID: ENSG00000115306 (Gene tree)
Gene ID: 6711
Gene Symbol: SPTBN1
Alias: N
Full Name: spectrin beta, non-erythrocytic 1
Gene Type: protein_coding
Specie: Homo_sapiens
Strand: Plus strand
Length: 215,162 bases
Position: chr2:54,456,285-54,671,446
Accession: 11275
Summary: Spectrin is an actin crosslinking and molecular scaffold protein that links the plasma membrane to the actin cytoskeleton, and functions in the determination of cell shape, arrangement of transmembrane proteins, and organization of organelles. It is composed of two antiparallel dimers of alpha- and beta- subunits. This gene is one member of a family of beta-spectrin genes. The encoded protein contains an N-terminal actin-binding domain, and 17 spectrin repeats which are involved in dimer formation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
27453046	Comprehensive Identification of RNA-Binding Domains in Human Cells	PolyT & Hela	2016 Aug 18	Castello A	DOI: 10.1016/j.molcel.2016.06.029
30352994	Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome capture	RIC & Jurkat	2018 Oct 23	Perez-Perri JI	DOI:10.1038/s41467-018-06557-8

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
11333019	The requirement for eukaryotic initiation factor 4A (elF4A) in translation is in direct proportion to the degree of mRNA 5' secondary structure.	RNA	2001 Mar	Svitkin YV	-

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000356805	SPTBN1-202	8482	XM_005264517	ENSP00000349259	2364 (aa)	XP_005264574	Q01082
ENST00000333896	SPTBN1-201	9075	-	ENSP00000334156	2155 (aa)	-	Q01082
ENST00000496323	SPTBN1-205	2225	-	-	- (aa)	-	-
ENST00000467371	SPTBN1-204	3332	-	-	- (aa)	-	-
ENST00000389980	SPTBN1-203	2164	-	ENSP00000374630	690 (aa)	-	F8W6C1
ENST00000602898	SPTBN1-206	2942	-	-	- (aa)	-	-
ENST00000615901	SPTBN1-207	10226	-	ENSP00000479037	2366 (aa)	-	A0A087WUZ3

Gene Model

Click here to download 's gene model file

Phenotype

ensgID	Trait	pValue	Pubmed ID
ENSG00000115306	Schizophrenia	4.11E-5	-
ENSG00000115306	Bipolar Disorder	4.13E-5	19488044
ENSG00000115306	Calcium	9.3170000E-005	-
ENSG00000115306	Fractures, Bone	6E-6	24430505
ENSG00000115306	Bone Density	2E-8	19801982
ENSG00000115306	Bone Density	4E-13	24430505
ENSG00000115306	Myopia, Degenerative	3E-7	22685421
ENSG00000115306	Bone Density	4E-6	19079262
ENSG00000115306	Bone Density	8E-7	18445777

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000115306	rs76070960	2	54457261	C	Intraocular pressure	29617998	[0.074-0.148] unit increase	0.1106	EFO_0004695
ENSG00000115306	rs11898505	2	54457420	A	Lumbar spine bone mineral density	29499414	[0.033-0.065] unit increase	0.0491	EFO_0007701
ENSG00000115306	rs11898505	2	54457420	G	Bone properties (heel)	24430505	[0.05-0.08] unit decrease	0.06	EFO_0004514
ENSG00000115306	rs4557020	2	54491044	T	Myopia (pathological)	22685421	[0.081-0.159] mm decrease	0.12	EFO_0004207
ENSG00000115306	rs11898505	2	54457420	G	Bone properties (heel)	24430505	[0.03-0.07] unit decrease	0.05	EFO_0005654
ENSG00000115306	rs11898505	2	54457420	G	Bone mineral density (spine)	19079262	[0.04-0.10] s.d. decrease	0.07	EFO_0003923
ENSG00000115306	rs11898505	2	54457420	A	Bone mineral density (spine)	19801982	[0.05-0.09] s.d. increase	0.07	EFO_0003923
ENSG00000115306	rs34138479	2	54620477	A	Heel bone mineral density	28869591	[0.048-0.07] unit decrease	0.058837	EFO_0009270
ENSG00000115306	rs34138479	2	54620477	A	Heel bone mineral density	28869591	[0.044-0.059] unit decrease	0.0517512	EFO_0009270
ENSG00000115306	rs34138479	2	54620477	A	Heel bone mineral density	28869591	[0.036-0.056] unit decrease	0.0456176	EFO_0009270
ENSG00000115306	rs11898505	2	54457420	A	Total body bone mineral density	29304378	unit increase	0.0342	EFO_0003923
ENSG00000115306	rs11898505	2	54457420	A	Bone ultrasound measurement (broadband ultrasound attenuation)	28472463	[0.07-0.11] unit increase	0.09	EFO_0004514
ENSG00000115306	rs11898505	2	54457420	A	Bone ultrasound measurement (broadband ultrasound attenuation)	28472463	[0.07-0.11] unit increase	0.09	EFO_0004514
ENSG00000115306	rs11898505	2	54457420	A	Bone ultrasound measurement (velocity of sound)	28472463	[0.05-0.09] unit increase	0.07	EFO_0004514
ENSG00000115306	rs11898505	2	54457420	G	Bone mineral density (spine)	18445777	[0.05-0.11] s.d. decrease	0.08	EFO_0003923
ENSG00000115306	rs34138479	2	54620477	?	Heel bone mineral density	30048462	[0.048-0.057] unit decrease	0.0524368	EFO_0009270
ENSG00000115306	rs11898505	2	54457420	?	Heel bone mineral density	30048462	[0.075-0.083] unit increase	0.0787181	EFO_0009270
ENSG00000115306	rs4671934	2	54460386	?	Heel bone mineral density	30048462	[0.014-0.022] unit decrease	0.017815	EFO_0009270
ENSG00000115306	rs67079536	2	54571707	?	Heel bone mineral density	30048462	[0.053-0.07] unit decrease	0.0616926	EFO_0009270
ENSG00000115306	rs28517733	2	54576074	?	Heel bone mineral density	30048462	[0.032-0.046] unit decrease	0.038974	EFO_0009270
ENSG00000115306	rs10180713	2	54577556	?	Heel bone mineral density	30048462	[0.048-0.057] unit decrease	0.0527968	EFO_0009270
ENSG00000115306	rs11402836	2	54592389	?	Heel bone mineral density	30048462	[0.016-0.025] unit decrease	0.0200728	EFO_0009270
ENSG00000115306	rs63629260	2	54668798	?	Heel bone mineral density	30048462	[0.11-0.17] unit decrease	0.139899	EFO_0009270
ENSG00000115306	rs75475627	2	54560455	C	Heel bone mineral density	30598549	[0.019-0.034] unit increase	0.0265001	EFO_0009270
ENSG00000115306	rs2271329	2	54655244	G	Heel bone mineral density	30598549	[0.013-0.023] unit decrease	0.0182739	EFO_0009270
ENSG00000115306	rs2971879	2	54661396	T	Heel bone mineral density	30598549	[0.037-0.047] unit decrease	0.042132	EFO_0009270
ENSG00000115306	rs2941584	2	54654484	C	Lumbar spine bone mineral density (trabecular)	27476799	[0.036-0.084] unit decrease	0.06	EFO_0007620
ENSG00000115306	rs2941584	2	54654484	C	Lumbar spine bone mineral density (integral)	27476799	[0.037-0.087] unit decrease	0.062	EFO_0007620
ENSG00000115306	rs75475627	2	54560455	?	White blood cell count	30595370			EFO_0004308
ENSG00000115306	rs10205410	2	54572462	?	Red blood cell count	30595370			EFO_0004305
ENSG00000115306	rs10181201	2	54572037	G	Estimated glomerular filtration rate	30604766	[-0.12972-0.38772] ml/min/1.73m2 decrease	0.129	EFO_0005208
ENSG00000115306	rs17046036	2	54628317	A	Estimated glomerular filtration rate	30604766	[0.021-0.299] ml/min/1.73m2 decrease	0.16	EFO_0005208
ENSG00000115306	rs7586066	2	54583355	A	Estimated glomerular filtration rate	30604766	[-0.02932-0.23332] ml/min/1.73m2 decrease	0.102	EFO_0005208
ENSG00000115306	rs2971887	2	54628000	?	Heel bone mineral density	30595370			EFO_0009270

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000115306's network

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy	Species
ENSG00000115306	SPTBN1	100	99.565	ENSMUSG00000020315	Sptbn1	100	98.948	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000165	MAPK cascade	-	TAS	Process
GO:0000281	mitotic cytokinesis

EuRBPDB

Note: to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Phenotype

GWAS

PPI

Ortholog

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.