EuRBPDB

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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
23320827CFL1 and Arp3 are biomarkers for metastasis and poor prognosis of squamous cell/adenosquamous carcinomas and adenocarcinomas of gallbladder.Cancer Invest2013 FebYang ZLdoi: 10.3109/07357907.2012.756113
15279900Decreased expression of the seven ARP2/3 complex genes in human gastric cancers.Cancer Lett2004 Aug 30Kaneda A-
28170369LMO2 Enhances Lamellipodia/Filopodia Formation in Basal-Type Breast Cancer Cells by Mediating ARP3-Profilin1 Interaction.Med Sci Monit2017 Feb 7Liu Y-

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
BLCAchr2113955632Missense_Mutationrs375902041I363V0.09
BLCAchr2113916973Missense_MutationnovelD64Y0.74
BRCAchr2113934285Missense_MutationNAL147V0.13
BRCAchr2113942183Splice_Regionnovel0.11
BRCAchr2113942357Nonsense_MutationNAE286*0.13
CESCchr2113934341SilentnovelG165G0.3
CESCchr2113951769Missense_MutationnovelR334H0.37
COADchr2113942342Missense_MutationNAI281L0.37
COADchr2113942309Missense_Mutationrs760969306D270N0.1
COADchr21138902355'UTRnovel0.37
COADchr2113951767SilentnovelR333R0.33
COADchr2113951543Missense_MutationNAP308H0.3
COADchr21139575893'UTRnovel0.15
COADchr2113940075Missense_MutationNAQ219H0.17
COADchr2113939979SilentNAG187G0.11
ESCAchr21139584103'UTRnovel0.42
ESCAchr2113934315Missense_MutationnovelQ157E0.12
GBMchr2113934338Silentrs371867071T164T0.06
GBMchr2113913203Nonsense_MutationnovelE26*0.52
GBMchr2113927438Missense_MutationnovelD107N0.29
GBMchr2113934329SilentnovelR161R0.3
HNSCchr2113957357Splice_Regionnovel0.15
KIRCchr2113927447Nonsense_MutationnovelF110*0.05
KIRPchr2113913211Missense_MutationnovelQ28H0.34
LGGchr2113942278SilentNAI259I0.42
LIHCchr2113934375Missense_MutationNAV177F0.2
LUADchr2113942248SilentnovelG249G0.07
LUADchr2113927450Missense_MutationNAL111V0.19
LUADchr2113934316Missense_MutationnovelQ157P0.1
LUADchr21139575343'UTRnovel0.29
LUADchr2113951547SilentNAI309I0.1
LUSCchr2113957442Missense_MutationnovelG415E0.18
LUSCchr2113931375SilentNAP137P0.45
LUSCchr2113942325Missense_MutationnovelR275I0.21
LUSCchr2113942210Missense_MutationnovelD237Y0.33
LUSCchr2113942199Missense_MutationnovelY233F0.39
LUSCchr2113927361Missense_MutationnovelG81V0.09
OVchr2113934311SilentnovelS155S0.03
PRADchr2113951511SilentnovelS297S0.44
READchr2113942189Missense_Mutationrs200071930R230C0.26
READchr2113957389Missense_MutationnovelK397N0.5
READchr2113940000SilentNAP194P0.45
READchr2113955625Splice_RegionNAP360P0.37
SKCMchr2113913220SilentNAI31I0.26
SKCMchr2113942183Splice_Regionnovel0.25
SKCMchr2113934307Missense_MutationNAT154I0.18
STADchr2113942214Missense_MutationNAL238S0.34
STADchr21139574973'UTRnovel0.34
STADchr2113942222Nonsense_MutationNAE241*0.32
STADchr2113913200Missense_MutationnovelT25A0.06
STADchr21139575723'UTRnovel0.57
THCAchr21139575343'UTRnovel0.13
UCECchr2113942222Nonsense_MutationNAE241*0.37
UCECchr21139582213'UTRnovel0.41
UCECchr2113942294Missense_MutationnovelK265E0.28
UCECchr2113951780Missense_MutationnovelD338Y0.25
UCECchr2113934329SilentnovelR161R0.24
UCECchr2113942222Nonsense_MutationNAE241*0.16
UCECchr2113913203Nonsense_MutationnovelE26*0.04
UCECchr2113942210Missense_MutationnovelD237Y0.15
UCECchr21139584773'UTRnovel0.41
UCECchr2113955672Missense_MutationnovelA376E0.46
UCECchr2113916885Splice_Regionrs201769858C34C0.16
UCECchr2113916955Missense_MutationnovelL58I0.3
UCECchr21139584563'UTRnovel0.4
UCECchr2113940040Silentrs779420771L208L0.3
UCECchr2113931332Missense_MutationnovelR123M0.46
UCECchr21139575653'UTRnovel0.09
UCECchr2113942309Missense_Mutationrs760969306D270N0.09
UCECchr21139577713'UTRnovel0.48
UCECchr21139581573'UTRnovel0.38
UCECchr21139583343'UTRnovel0.21
UCECchr21139578713'UTRnovel0.09
UCECchr21139584803'UTRnovel0.53
UCECchr21139578233'UTRnovel0.33
UCECchr21139584753'UTRnovel0.24
UCECchr21139582213'UTRnovel0.27
UCECchr2113942210Missense_MutationnovelD237Y0.54
UCECchr2113957452Silentrs779301166S418S0.5
UCECchr21139576333'UTRrs1897951620.4
UCECchr2113942293Missense_MutationnovelK264N0.17
UCECchr21139584773'UTRnovel0.24
UCECchr21138901545'UTRnovel0.5
UCECchr21139574763'UTRnovel0.27
UCECchr21139579163'UTRnovel0.23
UCECchr2113934343Missense_Mutationrs375240866T166M0.31
UCECchr2113940007Nonsense_MutationnovelG197*0.1
UCECchr2113942344Frame_Shift_InsnovelH284Sfs*60.26
UCECchr21139584803'UTRnovel0.14
UCECchr21138902425'UTRnovel0.29
UCECchr2113934355Missense_MutationnovelS170N0.24
UCSchr2113934339Missense_MutationnovelG165S0.42

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
ACCDEL0.17780.15279
PAADDEL0.0380.2014

Survival Analysis
CancerP-value Q-value
THYM0.024

Kaplan-Meier Survival Analysis

MESO0.0024

Kaplan-Meier Survival Analysis

ACC0.00037

Kaplan-Meier Survival Analysis

HNSC0.026

Kaplan-Meier Survival Analysis

SKCM0.00021

Kaplan-Meier Survival Analysis

LUSC0.021

Kaplan-Meier Survival Analysis

KIRP0.0019

Kaplan-Meier Survival Analysis

COAD0.027

Kaplan-Meier Survival Analysis

PAAD0.011

Kaplan-Meier Survival Analysis

CESC0.00013

Kaplan-Meier Survival Analysis

KICH0.0047

Kaplan-Meier Survival Analysis

UCEC0.00074

Kaplan-Meier Survival Analysis

LIHC0.0016

Kaplan-Meier Survival Analysis

LGG0.00011

Kaplan-Meier Survival Analysis

LUAD0.0041

Kaplan-Meier Survival Analysis

UVM0.0015

Kaplan-Meier Survival Analysis

OV0.031

Kaplan-Meier Survival Analysis

Drugs

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Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBPome
  • Literatures
  • Expression
  • Transcripts
  • Gene Model
  • Pathways
  • Phenotypes
  • PPI
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000115091 (Gene tree)
Gene ID
10096
Gene Symbol
ACTR3
Alias
ARP3
Full Name
actin related protein 3
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Plus strand
Length
72,663 bases
Position
chr2:113,889,934-113,962,596
Accession
170
RBP type
non-canonical RBP
Summary
The specific function of this gene has not yet been determined; however, the protein it encodes is known to be a major constituent of the ARP2/3 complex. This complex is located at the cell surface and is essential to cell shape and motility through lamellipodial actin assembly and protrusion. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Mar 2013]
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & MCF10A2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & U2OS2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
24630719Forgetting is regulated via Musashi-mediated translational control of the Arp2/3 complex.Cell2014 Mar 13Hadziselimovic Ndoi: 10.1016/j.cell.2014.01.054.
20004659Cortactin is implicated in murine zygotic development.Exp Cell Res2010 Mar 10Yu Ddoi: 10.1016/j.yexcr.2009.11.018
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000489779ACTR3-207545--- (aa)--
ENST00000263238ACTR3-2016718-ENSP00000263238418 (aa)-P61158
ENST00000484165ACTR3-206676--- (aa)--
ENST00000535589ACTR3-2081530-ENSP00000444987367 (aa)-B4DXW1
ENST00000443297ACTR3-203566-ENSP0000040312584 (aa)-F8WDR7
ENST00000478928ACTR3-2055965--- (aa)--
ENST00000446821ACTR3-204818-ENSP0000039421341 (aa)-F8WE84
ENST00000415792ACTR3-202676-ENSP0000040791234 (aa)-F8WEW2
Gene Model
Click here to download ENSG00000115091's gene model file
Pathways
Pathway IDPathway NameSource
hsa04530Tight junctionKEGG
Phenotypes
ensgIDTraitpValuePubmed ID
ENSG00000115091Cholesterol, HDL1.81918986805751E-517903299
ENSG00000115091Compliance8.848e-005-
ENSG00000115091Blood Pressure4.8700000E-006-
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000115091's network

* RBP PPI network refers to all genes directly bind to RBP
Orthologs identified by RBPome
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000115091ACTR39784.848FBgn0262716Arp310080.622Drosophila_melanogaster
ENSG00000115091ACTR3100100.000ENSMUSG00000026341Actr3100100.000Mus_musculus
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0005200structural constituent of cytoskeleton11741539.IDAFunction
GO:0005515protein binding20195357.IPIFunction
GO:0005524ATP binding-IEAFunction
GO:0005634nucleus16767080.17220302.IDAComponent
GO:0005737cytoplasm17220302.IDAComponent
GO:0005829cytosol-TASComponent
GO:0005885Arp2/3 protein complex11741539.17220302.IDAComponent
GO:0005885Arp2/3 protein complex9230079.TASComponent
GO:0005903brush border-IEAComponent
GO:0005911cell-cell junction-IEAComponent
GO:0005925focal adhesion21423176.HDAComponent
GO:0007163establishment or maintenance of cell polarity-IEAProcess
GO:0008356asymmetric cell division-IEAProcess
GO:0015629actin cytoskeleton9230079.TASComponent
GO:0016020membrane19946888.HDAComponent
GO:0016344meiotic chromosome movement towards spindle pole-IEAProcess
GO:0030027lamellipodium9230079.IDAComponent
GO:0033206meiotic cytokinesis-IEAProcess
GO:0034314Arp2/3 complex-mediated actin nucleation11741539.17220302.IDAProcess
GO:0035861site of double-strand break-ISSComponent
GO:0038096Fc-gamma receptor signaling pathway involved in phagocytosis-TASProcess
GO:0045944positive regulation of transcription by RNA polymerase II17220302.IDAProcess
GO:0048013ephrin receptor signaling pathway-TASProcess
GO:0051015actin filament binding11741539.IDAFunction
GO:0051653spindle localization-IEAProcess
GO:0060271cilium assembly20393563.IMPProcess
GO:0061024membrane organization-TASProcess
GO:0070062extracellular exosome19056867.20458337.23533145.HDAComponent
GO:0070358actin polymerization-dependent cell motility9230079.TASProcess
GO:0071346cellular response to interferon-gamma-IEAProcess
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