EuRBPDB

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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
25652905Expression and role of V1A subunit of V-ATPases in gastric cancer cells.Int J Clin Oncol2015 AugLiu Pdoi: 10.1007/s10147-015-0782-y
28592880Expression and Transcriptional Regulation of Human ATP6V1A Gene in Gastric Cancers.Sci Rep2017 Jun 7Wang Pdoi: 10.1038/s41598-017-03021-3.

Differential Expression

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
ACCchr3113809411Missense_Mutationrs140346248R613H0.04
BLCAchr3113781160Missense_MutationNAQ65E0.24
BLCAchr3113784275Missense_Mutationrs760842074V88A0.18
BLCAchr3113789829Missense_MutationNAS326C0.1
BLCAchr3113809400SilentNAQ609Q0.11
BLCAchr3113805516Missense_MutationnovelM584I0.52
BLCAchr3113805502Missense_MutationnovelK580Q0.61
BLCAchr3113786362Missense_MutationNAR232T0.49
BLCAchr3113784412Missense_Mutationrs111894180D134N0.16
BLCAchr3113786346Missense_MutationnovelL227V0.12
BLCAchr3113781124Missense_MutationNAE53Q0.5
BLCAchr3113805444Silentrs765616985Q560Q0.22
BLCAchr3113794959Missense_MutationnovelR359T0.19
BLCAchr3113805522Missense_MutationnovelF586L0.39
BRCAchr3113798258Missense_MutationNAD436H0.12
BRCAchr3113788802Missense_MutationNAS269T0.14
BRCAchr3113784272Missense_MutationNAS87F0.32
BRCAchr31138119803'UTRnovel0.24
BRCAchr3113781071Missense_Mutationrs367827756A35V0.07
BRCAchr3113805475Missense_MutationNAR571C0.14
CESCchr31138112783'UTRnovel0.32
CESCchr3113809422Missense_MutationnovelD617N0.18
CESCchr3113794932Missense_MutationNAS350C0.23
CESCchr3113805472Missense_MutationnovelI570V0.41
CESCchr3113788770SilentNAV258V0.3
CHOLchr31138095713'UTRnovel0.48
COADchr3113798446Splice_RegionNAK498K0.21
COADchr3113788856Missense_MutationnovelV287A0.13
COADchr3113805396Missense_MutationnovelM544I0.28
COADchr31138095713'UTRnovel0.37
COADchr3113794895Missense_MutationNAR338C0.36
COADchr3113784781Missense_MutationNAR171Q0.24
COADchr3113809422Missense_MutationNAD617Y0.1
COADchr3113786315SilentnovelP216P0.33
GBMchr3113784708Missense_MutationNAI147V0.04
GBMchr3113788781Missense_MutationnovelS262Y0.5
GBMchr3113809371Missense_Mutationrs758392307D600N0.21
GBMchr3113784410Nonsense_MutationnovelW133*0.08
GBMchr3113794895Missense_MutationNAR338C0.38
HNSCchr3113788793Missense_MutationnovelY266F0.31
KIRCchr3113809407Frame_Shift_DelnovelF612Sfs*620.27
KIRCchr3113781117Missense_MutationNAL50F0.14
KIRPchr3113784748Missense_Mutationrs760446373S160W0.35
KIRPchr3113786372SilentnovelD235D0.46
LGGchr3113795920Missense_MutationnovelA424V0.32
LGGchr3113798290SilentnovelP446P0.09
LIHCchr3113805469Missense_MutationNAI569V0.42
LIHCchr3113795097In_Frame_DelnovelP375_Y377del0.17
LUADchr3113805525Missense_MutationnovelK587N0.17
LUADchr3113805526Splice_SitenovelX587_splice0.16
LUADchr3113786357SilentnovelG230G0.3
LUADchr3113781094Missense_MutationnovelV43L0.54
LUADchr3113794904Missense_MutationnovelG341C0.23
LUADchr3113809400Missense_MutationNAQ609H0.07
LUADchr3113786333SilentNAP222P0.17
LUADchr3113798441Nonsense_MutationNAG497*0.17
LUADchr3113794955Missense_MutationNAL358I0.13
LUSCchr3113788821SilentnovelV275V0.06
LUSCchr3113795173Nonsense_MutationnovelE399*0.2
LUSCchr3113795909SilentNAP420P0.63
LUSCchr3113795910Missense_MutationNAV421I0.63
LUSCchr3113798277Missense_MutationNAR442H0.17
LUSCchr3113794923Missense_MutationnovelM347T0.05
LUSCchr3113805462SilentNAT566T0.28
LUSCchr3113803606Missense_MutationnovelK506N0.08
LUSCchr3113798243Missense_MutationnovelV431L0.44
LUSCchr3113809427Nonstop_MutationNA*618Yext*30.1
LUSCchr3113805372Missense_MutationNAK536N0.18
LUSCchr3113778818Missense_Mutationrs768359551H22R0.08
LUSCchr3113805368Missense_Mutationrs758773602Y535C0.35
LUSCchr3113788732Missense_MutationnovelT246A0.38
LUSCchr3113784717Missense_MutationnovelG150R0.2
LUSCchr3113781098Missense_MutationnovelR44T0.13
LUSCchr3113778741Splice_Regionnovel0.25
LUSCchr3113803616Missense_MutationnovelE510Q0.15
LUSCchr3113784333SilentNAS107S0.32
MESOchr3113809410Missense_MutationnovelR613C0.68
OVchr3113784422Missense_MutationnovelP137R0.11
OVchr3113778783SilentNAL10L0.14
OVchr3113786276Missense_MutationnovelF203L0.06
OVchr3113789808Missense_MutationnovelP319L0.6
OVchr3113798434SilentNAQ494Q0.28
PRADchr3113788829Missense_MutationNAG278V0.37
PRADchr3113795940Splice_SitenovelX430_splice0.29
READchr3113778804SilentnovelT17T0.07
READchr3113798368Silentrs753550267F472F0.41
READchr31138095633'UTRnovel0.48
SARCchr31138113433'UTRnovel0.22
SKCMchr31138094733'UTRnovel0.5
SKCMchr3113803668Missense_MutationnovelP527L0.3
SKCMchr3113784253Missense_MutationnovelR81C0.43
SKCMchr3113809409SilentNAF612F0.31
SKCMchr3113786324Silentrs200823060E219E0.33
SKCMchr31138094713'UTRnovel0.32
STADchr3113795105Missense_MutationnovelA376V0.18
STADchr31137787525'UTRnovel0.16
STADchr3113778784Missense_Mutationrs746407800D11N0.4
STADchr3113784716Silentrs767161754G149G0.38
STADchr3113789830Frame_Shift_DelnovelY328Lfs*180.26
STADchr3113784373Nonsense_MutationNAG121*0.15
STADchr3113784227Missense_MutationNAG72D0.18
THCAchr3113798419Frame_Shift_InsnovelA490Ifs*220.09
THCAchr3113798420Missense_MutationnovelA490T0.02
THYMchr3113778795SilentnovelK14K0.3
UCECchr31138095993'UTRnovel0.46
UCECchr3113798368Silentrs753550267F472F0.49
UCECchr3113780771Intronnovel0.35
UCECchr3113784781Missense_MutationNAR171Q0.29
UCECchr3113805384Missense_MutationnovelM540I0.17
UCECchr31138095433'UTRnovel0.21
UCECchr3113781058Missense_MutationnovelA31S0.37
UCECchr31138113743'UTRnovel0.24
UCECchr31138119403'UTRnovel0.17
UCECchr3113784254Missense_MutationnovelR81H0.3
UCECchr3113798417Missense_MutationNAL489M0.12
UCECchr3113795909Silentrs377421207P420P0.12
UCECchr3113784299Missense_MutationNAG96E0.13
UCECchr3113786360Missense_MutationnovelQ231H0.17
UCECchr3113798374SilentnovelP474P0.15
UCECchr3113798316Missense_MutationNAS455N0.38
UCECchr31138116023'UTRnovel0.32
UCECchr3113784382Missense_Mutationrs749209409V124M0.35
UCECchr3113795141Missense_MutationnovelR388Q0.31
UCECchr31138120383'UTRnovel0.55
UCECchr3113795877Missense_MutationnovelV410I0.27
UCECchr3113798373Missense_MutationnovelP474H0.4
UCECchr31138095793'UTRnovel0.33
UCECchr31138095803'UTRnovel0.33
UCECchr3113788767SilentNAT257T0.32
UCECchr31138094523'UTRnovel0.23
UCECchr31138095713'UTRnovel0.3
UCECchr31138095703'UTRnovel0.17
UCECchr31138116893'UTRnovel0.4
UCECchr3113809361Missense_MutationnovelK596N0.39
UCECchr31138119413'UTRrs168613510.29
UCECchr3113778781Missense_MutationnovelL10I0.41
UCECchr3113781112Missense_Mutationrs778431937E49K0.19
UCECchr3113798277Missense_MutationNAR442H0.22
UCECchr3113781133Nonsense_MutationnovelR56*0.13
UCECchr31138116063'UTRnovel0.09
UCECchr3113794952Missense_MutationnovelA357T0.43
UCECchr3113786383Missense_Mutationrs753834280P239L0.09
UCECchr3113784373Missense_MutationNAG121R0.38
UCECchr3113786384Splice_Siters755278709X239_splice0.44
UCECchr3113784743SilentNAE158E0.19
UCECchr31138120473'UTRnovel0.35
UCECchr3113784381Silentrs138089165N123N0.17
UCECchr3113784749Silentrs766110305S160S0.22
UCECchr3113788719SilentnovelV241V0.28
UCECchr3113788860SilentnovelL288L0.43

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
GBMDEL0.07970.00094652
KIRCDEL0.23670.11092
LGGDEL0.06430.04374

Survival Analysis
CancerP-value Q-value
THYM0.017

Kaplan-Meier Survival Analysis

KIRC0.00011

Kaplan-Meier Survival Analysis

MESO0.0037

Kaplan-Meier Survival Analysis

SKCM0.012

Kaplan-Meier Survival Analysis

PRAD0.014

Kaplan-Meier Survival Analysis

LUSC0.046

Kaplan-Meier Survival Analysis

TGCT0.039

Kaplan-Meier Survival Analysis

PAAD0.021

Kaplan-Meier Survival Analysis

PCPG0.034

Kaplan-Meier Survival Analysis

LAML0.015

Kaplan-Meier Survival Analysis

UCEC0.028

Kaplan-Meier Survival Analysis

LIHC0.049

Kaplan-Meier Survival Analysis

LGG0.00056

Kaplan-Meier Survival Analysis

Drugs

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Input Cell Line :


Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBPome
  • Literatures
  • Expression
  • Transcripts
  • Gene Model
  • Pathways
  • GWAS
  • PPI
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000114573 (Gene tree)
Gene ID
523
Gene Symbol
ATP6V1A
Alias
Vma1|VA68|VPP2|ATP6A1|ATP6V1A1
Full Name
ATPase H+ transporting V1 subunit A
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Plus strand
Length
65,040 bases
Position
chr3:113,747,019-113,812,058
Accession
851
RBP type
non-canonical RBP
Summary
This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c\, and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This encoded protein is one of two V1 domain A subunit isoforms and is found in all tissues. Transcript variants derived from alternative polyadenylation exist. [provided by RefSeq, Jul 2008]
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & HEK2932019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
29431736Capturing the interactome of newly transcribed RNARICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & U2OS2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
30917721Mitochondrial respiratory chain deficiency inhibits lysosomal hydrolysis.Autophagy2019 SepFernandez-Mosquera Ldoi: 10.1080/15548627.2019.1586256
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000461496ATP6V1A-202542--- (aa)--
ENST00000496747ATP6V1A-206710-ENSP00000417545184 (aa)-C9JA17
ENST00000470455ATP6V1A-2042266-ENSP0000042014649 (aa)-F8WDJ3
ENST00000475322ATP6V1A-205754-ENSP00000419294221 (aa)-C9JVW8
ENST00000273398ATP6V1A-2014591-ENSP00000273398617 (aa)-P38606
ENST00000462855ATP6V1A-203509--- (aa)--
Gene Model
Click here to download ENSG00000114573's gene model file
Pathways
Pathway IDPathway NameSource
hsa00190Oxidative phosphorylationKEGG
hsa01100Metabolic pathwaysKEGG
hsa04145PhagosomeKEGG
hsa04150mTOR signaling pathwayKEGG
hsa04721Synaptic vesicle cycleKEGG
hsa04966Collecting duct acid secretionKEGG
hsa05110Vibrio cholerae infectionKEGG
hsa05120Epithelial cell signaling in Helicobacter pylori infectionKEGG
hsa05165Human papillomavirus infectionKEGG
hsa05323Rheumatoid arthritisKEGG
GWAS
ensgIDSNPChromosomePositionSNP-risk TraitPubmedID95% CIOr or BEAT EFO ID
ENSG00000114573rs24652813113782573?Heel bone mineral density30595370EFO_0009270
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000114573's network

* RBP PPI network refers to all genes directly bind to RBP
Orthologs identified by RBPome
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000114573ATP6V1A9881.592WBGene00013025vha-139981.592Caenorhabditis_elegans
ENSG00000114573ATP6V1A10098.055ENSMUSG00000052459Atp6v1a10098.701Mus_musculus
ENSG00000114573ATP6V1A10066.486YDL185WVMA16065.320Saccharomyces_cerevisiae
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0005524ATP binding-IEAFunction
GO:0005765lysosomal membrane17897319.HDAComponent
GO:0005774vacuolar membrane21873635.IBAComponent
GO:0005829cytosol-ISSComponent
GO:0005829cytosol-TASComponent
GO:0005886plasma membrane21873635.IBAComponent
GO:0005886plasma membrane-ISSComponent
GO:0005886plasma membrane8463241.TASComponent
GO:0005902microvillus-IEAComponent
GO:0006879cellular iron ion homeostasis28296633.IMPProcess
GO:0008286insulin receptor signaling pathway-TASProcess
GO:0015991ATP hydrolysis coupled proton transport-IEAProcess
GO:0016241regulation of macroautophagy22982048.NASProcess
GO:0016324apical plasma membrane-IEAComponent
GO:0016469proton-transporting two-sector ATPase complex8463241.TASComponent
GO:0033180proton-transporting V-type ATPase, V1 domain-IEAComponent
GO:0033572transferrin transport-TASProcess
GO:0034220ion transmembrane transport-TASProcess
GO:0036295cellular response to increased oxygen levels28296633.IMPProcess
GO:0046034ATP metabolic process-IEAProcess
GO:0046961proton-transporting ATPase activity, rotational mechanism21873635.IBAFunction
GO:0070062extracellular exosome19056867.19199708.20458337.23533145.HDAComponent
GO:0090383phagosome acidification-TASProcess
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