EuRBPDB

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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
24423449Suppression of GNAI2 message in ovarian cancer.J Ovarian Res2014 Jan 14Raymond JR Jrdoi: 10.1186/1757-2215-7-6.
22936789The essential role of Giα2 in prostate cancer cell migration.Mol Cancer Res2012 OctZhong Mdoi: 10.1158/1541-7786.MCR-12-0219
27811362MicroRNA-222-3p/GNAI2/AKT axis inhibits epithelial ovarian cancer cell growth and associates with good overall survival.Oncotarget2016 Dec 6Fu Xdoi: 10.18632/oncotarget.13017.

Differential Expression

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
BLCAchr350257657Missense_MutationnovelI345M0.09
BLCAchr350253084Missense_MutationnovelD122H0.4
BLCAchr350256222SilentnovelQ165Q0.15
BLCAchr350253075Missense_Mutationrs150943193V119M0.41
BLCAchr350252404Missense_MutationnovelH57D0.39
BRCAchr350257511Missense_MutationnovelY297H0.38
BRCAchr350256768Silentrs781916903I213I0.15
BRCAchr350236444Missense_MutationNAL37M0.4
BRCAchr350246954Intronnovel0.21
BRCAchr350252240Intronnovel0.06
BRCAchr350256835Missense_MutationnovelA236S0.1
BRCAchr350252527Missense_MutationNAP98S0.4
BRCAchr350257630SilentnovelV336V0.14
CESCchr3502586633'UTRnovel0.47
CESCchr3502362365'UTRnovel0.67
CESCchr350251871Intronnovel0.17
CESCchr350251479Intronnovel0.5
CESCchr3502590643'UTRnovel0.38
CESCchr350256202Missense_Mutationrs781807470D159N0.21
CESCchr3502589643'UTRnovel0.37
COADchr350257500Missense_MutationnovelG293E0.3
COADchr350257588Silentrs377114196T322T0.42
COADchr350252439SilentNAQ68Q0.16
COADchr350252435Missense_Mutationrs781986131R67Q0.09
COADchr350256270SilentNAK181K0.2
COADchr350257677Missense_MutationNAC352Y0.29
COADchr350257604Missense_MutationnovelT328S0.08
COADchr350252524Missense_Mutationrs782148570D97N0.39
ESCAchr3502589793'UTRnovel0.29
ESCAchr350256816Silentrs587657823S229S0.42
GBMchr350257082Missense_MutationnovelE290V0.24
GBMchr350257502Missense_MutationnovelA294P0.16
GBMchr350257626Missense_MutationnovelF335Y0.28
HNSCchr350256207SilentnovelL160L0.13
HNSCchr350252397Splice_RegionnovelK54K0.24
HNSCchr350256276SilentnovelT183T0.44
KIRCchr350256823Missense_MutationNAD232Y0.29
KIRCchr350257057In_Frame_InsnovelS282delinsIKR0.1
KIRCchr350257058Missense_MutationNAS282N0.07
KIRCchr350253029Silentrs781903414D103D0.11
KIRPchr350257012Missense_MutationnovelL267I0.74
KIRPchr350256848Missense_MutationNAE240A0.41
LAMLchr350257575Missense_MutationnovelK318M0.1
LGGchr350256276SilentnovelT183T0.31
LGGchr350256810SilentnovelA227A0.2
LUADchr350251747Intronnovel0.29
LUSCchr350252511Missense_MutationnovelQ92H0.33
LUSCchr350257627Silentrs781851724F335F0.33
LUSCchr350257716Splice_Sitenovel0.28
LUSCchr350252348Intronnovel0.12
OVchr350253055Missense_MutationnovelC112Y0.07
OVchr3502586693'UTRrs5877119260.45
OVchr350257030Frame_Shift_DelnovelD273Pfs*30.15
OVchr350251645Intronnovel0.07
OVchr350253060Missense_Mutationrs368004918A114T0.18
PAADchr350253060Missense_Mutationrs368004918A114T0.15
PRADchr350252481Missense_MutationNAM82I0.36
PRADchr350253106Missense_Mutationrs782279425R129Q0.3
READchr350252310Intronnovel0.35
READchr350256759Missense_MutationNAK210N0.26
READchr350256966Silentrs781818717F251F0.25
SKCMchr350252384Intronnovel0.52
SKCMchr350252531Missense_MutationnovelS99Y0.17
SKCMchr350256262Missense_Mutationrs137853226R179C0.28
SKCMchr350256262Missense_Mutationrs137853226R179C0.36
SKCMchr350257063Silentrs142945610L284L0.47
SKCMchr350256262Missense_Mutationrs137853226R179C0.32
SKCMchr350256261SilentnovelT178T0.49
SKCMchr350256262Missense_Mutationrs137853226R179C0.48
SKCMchr350251667Intronnovel0.45
SKCMchr350252528Missense_MutationnovelP98L0.37
SKCMchr350252074Intronnovel0.15
SKCMchr350256272Missense_MutationNAT182I0.58
SKCMchr350256273SilentnovelT182T0.6
SKCMchr350252091Intronnovel0.4
SKCMchr350252529SilentNAP98P0.2
SKCMchr350253122Silentrs781916310D134D0.11
SKCMchr350252091Intronnovel0.31
SKCMchr350256810SilentNAA227A0.46
SKCMchr350256189Splice_Regionnovel0.53
SKCMchr350256272Missense_MutationNAT182I0.44
STADchr350252447Missense_Mutationrs138213627A71V0.33
STADchr350256257Missense_Mutationrs782599019R177Q0.29
STADchr350252418SilentnovelY61Y0.43
STADchr350256784Missense_Mutationrs782631757V219I0.15
STADchr350256804Silentrs141703681C225C0.06
STADchr350256283Missense_MutationNAV186M0.3
UCECchr3502587603'UTRnovel0.3
UCECchr3502592103'UTRnovel0.46
UCECchr350252163Intronnovel0.47
UCECchr3502588283'UTRnovel0.45
UCECchr350256222Missense_MutationnovelQ165H0.17
UCECchr350256740Missense_MutationnovelG204D0.34
UCECchr350252515Missense_Mutationrs183955200D94N0.48
UCECchr350256238Missense_MutationNAT171A0.38
UCECchr350257645Silentrs147937896T341T0.29
UCECchr3502585923'UTRnovel0.19
UCECchr350252128SilentnovelI49I0.24
UCECchr350252231Intronnovel0.41
UCECchr350253132Nonsense_MutationNAQ138*0.27
UCECchr3502588993'UTRnovel0.4
UCECchr3502588603'UTRnovel0.35
UCECchr350252341Intronnovel0.4
UCECchr350253074SilentnovelG118G0.52
UCECchr350257600Silentrs587605417C326C0.3
UCECchr350252342Intronnovel0.31
UCECchr350256211Missense_MutationnovelR162C0.38
UCECchr350256936Splice_SitenovelX242_splice0.31
UCECchr350256937Missense_MutationNAN242H0.5
UCECchr3502589743'UTRrs7822029300.37
UCECchr350257601Missense_Mutationrs782786744A327T0.37
UCECchr3502592103'UTRnovel0.45
UCECchr350257646Missense_MutationnovelD342N0.44
UCECchr350251478Intronnovel0.29
UCECchr350257568Missense_MutationnovelD316Y0.36
UCECchr350256823Missense_MutationNAD232Y0.43
UCECchr350252448Silentrs782465410A71A0.25
UCECchr350256840Missense_MutationnovelE237D0.26
UCECchr350256966Silentrs781818717F251F0.17
UCECchr350251662Intronnovel0.49
UCECchr350253140Frame_Shift_InsnovelG142Wfs*260.43
UCECchr350251662Intronnovel0.34
UCSchr350253150Frame_Shift_DelnovelS144Qfs*140.06

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
BRCADEL0.28244.5968e-31
CHOLDEL0.77780.016387
DLBCDEL0.10420.18166
GBMDEL0.07630.056565
KIRPAMP0.23260.14801
LGGDEL0.07990.00089193
LUADDEL0.33910.0021265
PAADDEL0.19020.030662
SARCDEL0.22180.0034746
SKCMDEL0.16350.13887
TGCTAMP0.120.23596
TGCTDEL0.18670.08422
THCADEL0.0060.221
THYMDEL0.07320.037527
UCSDEL0.46430.19877
UVMDEL0.53750.22482

Survival Analysis
CancerP-value Q-value
THYM0.02

Kaplan-Meier Survival Analysis

SKCM0.0012

Kaplan-Meier Survival Analysis

LUSC0.023

Kaplan-Meier Survival Analysis

BRCA0.00016

Kaplan-Meier Survival Analysis

ESCA0.034

Kaplan-Meier Survival Analysis

TGCT0.047

Kaplan-Meier Survival Analysis

PAAD0.028

Kaplan-Meier Survival Analysis

PCPG0.034

Kaplan-Meier Survival Analysis

READ0.019

Kaplan-Meier Survival Analysis

LAML0.0084

Kaplan-Meier Survival Analysis

UCEC0.031

Kaplan-Meier Survival Analysis

LIHC0.016

Kaplan-Meier Survival Analysis

LGG0.0046

Kaplan-Meier Survival Analysis

CHOL0.042

Kaplan-Meier Survival Analysis

UVM0.0052

Kaplan-Meier Survival Analysis

Drugs

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Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBPome
  • Expression
  • Transcripts
  • Gene Model
  • Pathways
  • GWAS
  • PPI
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000114353 (Gene tree)
Gene ID
2771
Gene Symbol
GNAI2
Alias
GIP|GNAI2B
Full Name
G protein subunit alpha i2
Gene Type
protein_coding
Species
Homo_sapiens
Status
putative
Strand
Plus strand
Length
33,064 bases
Position
chr3:50,226,292-50,259,355
Accession
4385
RBP type
non-canonical RBP
Summary
The protein encoded by this gene is an alpha subunit of guanine nucleotide binding proteins (G proteins). The encoded protein contains the guanine nucleotide binding site and is involved in the hormonal regulation of adenylate cyclase. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013]
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & Hela2018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & MCF10A2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & U2OS2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000266027GNAI2-2012169-ENSP00000266027303 (aa)-P04899
ENST00000446079GNAI2-2062086-ENSP00000406065146 (aa)-F8WBG4
ENST00000492383GNAI2-212989--- (aa)--
ENST00000468422GNAI2-208531--- (aa)--
ENST00000490122GNAI2-2102445--- (aa)--
ENST00000480090GNAI2-209284--- (aa)--
ENST00000313601GNAI2-2022464-ENSP00000312999355 (aa)-P04899
ENST00000491100GNAI2-2113886--- (aa)--
ENST00000440628GNAI2-2041663-ENSP00000395736303 (aa)-P04899
ENST00000441156GNAI2-2052168-ENSP00000394321142 (aa)-F8WE78
ENST00000451956GNAI2-2071486-ENSP00000406369318 (aa)-P04899
ENST00000422163GNAI2-2032407-ENSP00000406871339 (aa)-P04899
Gene Model
Click here to download ENSG00000114353's gene model file
Pathways
Pathway IDPathway NameSource
hsa04015Rap1 signaling pathwayKEGG
hsa04022cGMP-PKG signaling pathwayKEGG
hsa04024cAMP signaling pathwayKEGG
hsa04062Chemokine signaling pathwayKEGG
hsa04071Sphingolipid signaling pathwayKEGG
hsa04261Adrenergic signaling in cardiomyocytesKEGG
hsa04360Axon guidanceKEGG
hsa04371Apelin signaling pathwayKEGG
hsa04540Gap junctionKEGG
hsa04611Platelet activationKEGG
hsa04670Leukocyte transendothelial migrationKEGG
hsa04713Circadian entrainmentKEGG
hsa04723Retrograde endocannabinoid signalingKEGG
hsa04724Glutamatergic synapseKEGG
hsa04725Cholinergic synapseKEGG
hsa04726Serotonergic synapseKEGG
hsa04727GABAergic synapseKEGG
hsa04728Dopaminergic synapseKEGG
hsa04730Long-term depressionKEGG
hsa04914Progesterone-mediated oocyte maturationKEGG
hsa04915Estrogen signaling pathwayKEGG
hsa04916MelanogenesisKEGG
hsa04921Oxytocin signaling pathwayKEGG
hsa04923Regulation of lipolysis in adipocytesKEGG
hsa04924Renin secretionKEGG
hsa04926Relaxin signaling pathwayKEGG
hsa04928Parathyroid hormone synthesis, secretion and actionKEGG
hsa04934Cushing syndromeKEGG
hsa04971Gastric acid secretionKEGG
hsa05012Parkinson diseaseKEGG
hsa05030Cocaine addictionKEGG
hsa05032Morphine addictionKEGG
hsa05034AlcoholismKEGG
hsa05133PertussisKEGG
hsa05142Chagas disease (American trypanosomiasis)KEGG
hsa05145ToxoplasmosisKEGG
hsa05163Human cytomegalovirus infectionKEGG
hsa05170Human immunodeficiency virus 1 infectionKEGG
hsa05200Pathways in cancerKEGG
GWAS
ensgIDSNPChromosomePositionSNP-risk TraitPubmedID95% CIOr or BEAT EFO ID
ENSG00000114353rs2298952350249521ACognitive performance30038396[0.019-0.038] unit decrease0.0283EFO_0008354
ENSG00000114353rs2097247350253470TFeeling tense29500382z score increase5.94EFO_0009596
ENSG00000114353rs181394846350255960CMacrophage inflammatory protein 1b levels27989323[0.14-0.27] SD units decrease0.2059EFO_0008219
ENSG00000114353rs62260798350236846TMorning person306968231.0527EFO_0008328
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000114353's network

* RBP PPI network refers to all genes directly bind to RBP
Orthologs identified by RBPome
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000114353GNAI210098.310ENSMUSG00000032562Gnai2100100.000Mus_musculus
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0001664G protein-coupled receptor binding21873635.IBAFunction
GO:0001973adenosine receptor signaling pathway21873635.IBAProcess
GO:0003924GTPase activity21873635.IBAFunction
GO:0005515protein binding16189514.16782902.18599439.23773523.25241761.25416956.IPIFunction
GO:0005525GTP binding-IEAFunction
GO:0005654nucleoplasm-IDAComponent
GO:0005737cytoplasm17635935.IDAComponent
GO:0005813centrosome17635935.IDAComponent
GO:0005829cytosol-IDAComponent
GO:0005834heterotrimeric G-protein complex21873635.IBAComponent
GO:0005886plasma membrane17635935.IDAComponent
GO:0005886plasma membrane-TASComponent
GO:0006457protein folding-TASProcess
GO:0007049cell cycle-IEAProcess
GO:0007165signal transduction7961880.9637720.TASProcess
GO:0007186G protein-coupled receptor signaling pathway-TASProcess
GO:0007188adenylate cyclase-modulating G protein-coupled receptor signaling pathway21873635.IBAProcess
GO:0007189adenylate cyclase-activating G protein-coupled receptor signaling pathway-IEAProcess
GO:0007193adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway21873635.IBAProcess
GO:0007193adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway-TASProcess
GO:0007194negative regulation of adenylate cyclase activity9637720.TASProcess
GO:0007213G protein-coupled acetylcholine receptor signaling pathway-IEAProcess
GO:0007214gamma-aminobutyric acid signaling pathway21873635.IBAProcess
GO:0007584response to nutrient8587610.TASProcess
GO:0008283cell proliferation-IEAProcess
GO:0008284positive regulation of cell proliferation21079996.IMPProcess
GO:0016020membrane19946888.HDAComponent
GO:0030335positive regulation of cell migration-IEAProcess
GO:0030425dendrite-IEAComponent
GO:0030496midbody17635935.IDAComponent
GO:0031683G-protein beta/gamma-subunit complex binding21873635.IBAFunction
GO:0032930positive regulation of superoxide anion generation-IEAProcess
GO:0033864positive regulation of NAD(P)H oxidase activity-IEAProcess
GO:0035810positive regulation of urine volume-IEAProcess
GO:0035815positive regulation of renal sodium excretion-IEAProcess
GO:0044297cell body-IEAComponent
GO:0045121membrane raft-IEAComponent
GO:0045955negative regulation of calcium ion-dependent exocytosis-IEAProcess
GO:0046628positive regulation of insulin receptor signaling pathway-IEAProcess
GO:0046872metal ion binding-IEAFunction
GO:0050805negative regulation of synaptic transmission-IEAProcess
GO:0051301cell division17635935.IMPProcess
GO:0051924regulation of calcium ion transport-IEAProcess
GO:0070062extracellular exosome12519789.19056867.19199708.20458337.HDAComponent
GO:0070374positive regulation of ERK1 and ERK2 cascade-IEAProcess
GO:0140199negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process-IEAProcess
GO:1903561extracellular vesicle24769233.HDAComponent
GO:1903614negative regulation of protein tyrosine phosphatase activity-IEAProcess
GO:1904707positive regulation of vascular smooth muscle cell proliferation-IEAProcess
GO:2000179positive regulation of neural precursor cell proliferation-IEAProcess
GO:2001234negative regulation of apoptotic signaling pathway-IEAProcess
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