EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
23708665	Prolactin suppresses a progestin-induced CK5-positive cell population in luminal breast cancer through inhibition of progestin-driven BCL6 expression.	Oncogene	2014 Apr 24	Sato T	doi: 10.1038/onc.2013.172
24220798	Morphological and quantitative analysis of BCL6 expression in human colorectal carcinogenesis.	Oncol Rep	2014 Jan	Sena P	doi: 10.3892/or.2013.2846
28671040	High expressions of BCL6 and Lewis y antigen are correlated with high tumor burden and poor prognosis in epithelial ovarian cancer.	Tumour Biol	2017 Jul	Zhu L	doi: 10.1177/1010428317711655.
27186677	MicroRNA-544 down-regulates both Bcl6 and Stat3 to inhibit tumor growth of human triple negative breast cancer.	Biol Chem	2016 Oct 1	Zhu Z	doi: 10.1515/hsz-2016-0104.
26553360	miR-339-5p inhibits migration and invasion in ovarian cancer cell lines by targeting NACC1 and BCL6.	Tumour Biol	2016 Apr	Shan W	doi: 10.1007/s13277-015-4390-2
18776761	BCL6 expression correlates with monomorphic histology in children with posttransplantation lymphoproliferative disease.	J Pediatr Hematol Oncol	2008 Sep	Porter CC	doi: 10.1097/MPH.0b013e31817eb7ca.
22395507	Immunologic and cytogenetic markers expressed in non-Hodgkin lymphoma of head and neck.	Rom J Morphol Embryol	2012	Grigore R	-
24878528	High concentrations of glucose suppress etoposide-induced cell death of B-cell lymphoma through BCL-6.	Biochem Biophys Res Commun	2014 Jul 18	Shao Y	doi: 10.1016/j.bbrc.2014.05.096
19925052	Prognostic immunophenotypic biomarker studies in diffuse large B cell lymphoma with special emphasis on rational determination of cut-off scores.	Leuk Lymphoma	2010 Feb	Tzankov A	doi: 10.3109/10428190903370338.
12835729	The BCL6 gene in B-cell lymphomas with 3q27 translocations is expressed mainly from the rearranged allele irrespective of the partner gene.	Leukemia	2003 Jul	Lossos IS	-
27881582	The Expanding Role of the BCL6 Oncoprotein as a Cancer Therapeutic Target.	Clin Cancer Res	2017 Feb 15	Cardenas MG	doi: 10.1158/1078-0432.CCR-16-2071
27764808	The feedback loop of LITAF and BCL6 is involved in regulating apoptosis in B cell non-Hodgkin's-lymphoma.	Oncotarget	2016 Nov 22	Shi Y	doi: 10.18632/oncotarget.12680.
28256570	Recurrent BCOR internal tandem duplication and BCOR or BCL6 expression distinguish primitive myxoid mesenchymal tumor of infancy from congenital infantile fibrosarcoma.	Mod Pathol	2017 Jun	Santiago T	doi: 10.1038/modpathol.2017.12
30420967	Knockdown of BCL6 Inhibited Malignant Phenotype and Enhanced Sensitivity of Glioblastoma Cells to TMZ through AKT Pathway.	Biomed Res Int	2018 Oct 18	Song W	doi: 10.1155/2018/6953506
24917186	B-cell lymphoma 6 protein stimulates oncogenicity of human breast cancer cells.	BMC Cancer	2014 Jun 10	Wu Q	doi: 10.1186/1471-2407-14-418.
19816083	BCL-6 oncoprotein in breast cancer: loss of expression in disease progression.	Pathobiology	2009	Pinto AE	doi: 10.1159/000228899
20124477	Prolactin inhibits BCL6 expression in breast cancer through a Stat5a-dependent mechanism.	Cancer Res	2010 Feb 15	Tran TH	doi: 10.1158/0008-5472.CAN-09-2314
26049022	BCL6 induces EMT by promoting the ZEB1-mediated transcription repression of E-cadherin in breast cancer cells.	Cancer Lett	2015 Sep 1	Yu JM	doi: 10.1016/j.canlet.2015.05.029
23269799	B cells in chronically hepatitis C virus-infected individuals lack a virus-induced mutation signature in the TP53, CTNNB1, and BCL6 genes.	J Virol	2013 Mar	Tucci FA	doi: 10.1128/JVI.03081-12
27237631	Clinical significance of T-bet, GATA-3, and Bcl-6 transcription factor expression in bladder carcinoma.	J Transl Med	2016 May 30	Bahria-Sediki IB	doi: 10.1186/s12967-016-0891-z.
29510377	miR-519d-3p Inhibits Cell Proliferation and Invasion of Gastric Cancer by Downregulating B-Cell Lymphoma 6.	Cytogenet Genome Res	2018	Li YY	doi: 10.1159/000487372

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
BLCA	chr3	187729663	Missense_Mutation	novel	E248Q	0.15
BLCA	chr3	187729838	Frame_Shift_Del	novel	*L184Hfs22**	0.09
BLCA	chr3	187729058	Silent	rs780615769	I449I	0.19
BLCA	chr3	187726837	Silent	novel	K534K	0.23
BLCA	chr3	187729188	Missense_Mutation	rs369842677	R406Q	0.11
BRCA	chr3	187729689	Missense_Mutation	rs759501076	P239L	0.11
BRCA	chr3	187729427	Missense_Mutation	novel	K326N	0.69
BRCA	chr3	187729695	Missense_Mutation	NA	P237L	0.28
BRCA	chr3	187728473	Missense_Mutation	rs535108808	T476M	0.45
BRCA	chr3	187733631	Missense_Mutation	NA	N21K	0.15
CESC	chr3	187722051	3'Flank	novel		0.34
CESC	chr3	187721755	3'Flank	novel		0.21
CESC	chr3	187725585	Missense_Mutation	NA	R585W	0.21	zf-C2H2
CESC	chr3	187725505	Frame_Shift_Del	novel	*F611Lfs35**	0.22
CESC	chr3	187725604	Silent	NA	I578I	0.33
CESC	chr3	187722504	Missense_Mutation	rs750212558	R692H	0.47
CESC	chr3	187729468	Missense_Mutation	novel	A313T	0.51
CESC	chr3	187733779	Intron	NA		0.54
CESC	chr3	187729640	Missense_Mutation	novel	H255Q	0.09
CESC	chr3	187721717	3'Flank	novel		0.47
CESC	chr3	187733661	Silent	novel	F11F	0.5
CESC	chr3	187729754	Silent	novel	R217R	0.23
COAD	chr3	187725557	Missense_Mutation	NA	R594Q	0.19	zf-C2H2
COAD	chr3	187722496	Missense_Mutation	novel	A695T	0.18
COAD	chr3	187728482	Frame_Shift_Del	novel	*P473Rfs117**	0.48
COAD	chr3	187726828	Silent	rs142294621	T537T	0.32
COAD	chr3	187729107	Missense_Mutation	NA	A433V	0.31
COAD	chr3	187725000	Missense_Mutation	NA	R640W	0.27
COAD	chr3	187726852	Silent	novel	E529E	0.35
COAD	chr3	187729842	Missense_Mutation	novel	L188P	0.14
COAD	chr3	187726889	Missense_Mutation	rs776993725	A517V	0.4
COAD	chr3	187725557	Missense_Mutation	NA	R594Q	0.32	zf-C2H2
COAD	chr3	187725557	Missense_Mutation	NA	R594Q	0.12	zf-C2H2
COAD	chr3	187729596	Missense_Mutation	rs780987785	R270Q	0.17
COAD	chr3	187729447	Frame_Shift_Ins	NA	*N320Qfs11**	0.27
COAD	chr3	187729131	Missense_Mutation	novel	L425R	0.07
COAD	chr3	187729986	Missense_Mutation	NA	R140H	0.22
ESCA	chr3	187721386	3'Flank	novel		0.45
GBM	chr3	187729741	Missense_Mutation	novel	N222Y	0.37
GBM	chr3	187729058	Silent	rs780615769	I449I	0.44
GBM	chr3	187729986	Missense_Mutation	NA	R140H	0.05
GBM	chr3	187725000	Missense_Mutation	NA	R640W	0.72
GBM	chr3	187726790	Missense_Mutation	rs147650939	R550H	0.1
GBM	chr3	187725527	Missense_Mutation	NA	C604Y	0.41
HNSC	chr3	187729359	Missense_Mutation	novel	S349N	0.18
HNSC	chr3	187729623	Missense_Mutation	novel	P261R	0.3
HNSC	chr3	187729824	Missense_Mutation	novel	S194C	0.13
HNSC	chr3	187725574	Nonsense_Mutation	novel	*N588delinsKGEERARP**	0.04	zf-C2H2
HNSC	chr3	187731812	Missense_Mutation	rs781532443	R94W	0.29
HNSC	chr3	187729529	Frame_Shift_Del	novel	*Y293Tfs31**	0.29
HNSC	chr3	187729796	Silent	novel	V203V	0.27
KIRC	chr3	187728459	Nonsense_Mutation	NA	Q481*	0.13
KIRC	chr3	187729611	Missense_Mutation	NA	I265N	0.28
KIRC	chr3	187729060	Missense_Mutation	rs775834769	I449V	0.22
KIRP	chr3	187728490	Missense_Mutation	novel	M470I	0.51
LGG	chr3	187731757	Missense_Mutation	NA	L112P	0.27
LGG	chr3	187729389	Frame_Shift_Del	novel	*D338Afs93**	0.06
LGG	chr3	187729670	Silent	rs2228258	P245P	0.33
LGG	chr3	187729888	Missense_Mutation	NA	P173S	0.04
LIHC	chr3	187733624	Missense_Mutation	novel	R24S	0.37
LIHC	chr3	187731743	Missense_Mutation	NA	V117F	0.36
LIHC	chr3	187729892	Silent	rs751896144	S171S	0.94
LIHC	chr3	187728412	Silent	rs370060611	T496T	0.19
LUAD	chr3	187728482	Frame_Shift_Del	novel	*P473Rfs117**	0.22
LUAD	chr3	187722504	Missense_Mutation	rs750212558	R692H	0.15
LUAD	chr3	187729191	Missense_Mutation	NA	P405L	0.08
LUAD	chr3	187722517	Missense_Mutation	novel	K688E	0.06
LUAD	chr3	187726798	Missense_Mutation	novel	K547N	0.35
LUAD	chr3	187729755	Missense_Mutation	rs142220629	R217Q	0.21
LUAD	chr3	187725035	Missense_Mutation	novel	K628R	0.2
LUAD	chr3	187729436	Silent	novel	L323L	0.37
LUAD	chr3	187728393	Missense_Mutation	novel	E503K	0.35
LUAD	chr3	187729751	Missense_Mutation	NA	M218I	0.25
LUAD	chr3	187729764	Missense_Mutation	NA	R214L	0.18
LUAD	chr3	187729340	Silent	NA	I355I	0.11
LUSC	chr3	187725038	Missense_Mutation	NA	E627G	0.27
LUSC	chr3	187726756	Silent	rs780876409	L561L	0.24
LUSC	chr3	187729457	Silent	rs764883977	F316F	0.28
LUSC	chr3	187731874	Missense_Mutation	rs760006045	N73S	0.14
LUSC	chr3	187733657	Missense_Mutation	NA	R13G	0.4
LUSC	chr3	187729895	Silent	novel	R170R	0.13
LUSC	chr3	187731921	Silent	novel	F57F	0.46
LUSC	chr3	187733698	5'UTR	novel		0.25
LUSC	chr3	187729674	Missense_Mutation	NA	R244L	0.18
LUSC	chr3	187729779	Missense_Mutation	novel	S209C	0.07
LUSC	chr3	187733591	Missense_Mutation	novel	V35F	0.04
LUSC	chr3	187726814	Missense_Mutation	novel	S542N	0.04
OV	chr3	187722549	Missense_Mutation	novel	L677S	0.12
OV	chr3	187729527	Missense_Mutation	NA	Y293F	0.2
PAAD	chr3	187729369	Missense_Mutation	novel	E346K	0.16
PAAD	chr3	187729864	Missense_Mutation	novel	A181T	0.33
PAAD	chr3	187731821	Missense_Mutation	novel	Y91H	0.04
PRAD	chr3	187733547	Silent	NA	V49V	0.05
PRAD	chr3	187729444	Missense_Mutation	NA	A321T	0.06
PRAD	chr3	187729755	Missense_Mutation	rs142220629	R217Q	0.28
PRAD	chr3	187729857	Missense_Mutation	NA	S183N	0.41
READ	chr3	187724969	Missense_Mutation	NA	R650Q	0.25
READ	chr3	187729178	Silent	rs750915742	T409T	0.23
READ	chr3	187729400	Missense_Mutation	novel	Q335H	0.47
SARC	chr3	187729254	Missense_Mutation	novel	N384S	0.06
SARC	chr3	187725615	Missense_Mutation	rs755666072	R575C	0.32
SKCM	chr3	187725066	Missense_Mutation	NA	R618C	0.13
SKCM	chr3	187729976	Silent	novel	F143F	0.31
SKCM	chr3	187729119	Missense_Mutation	novel	T429I	0.37
SKCM	chr3	187729467	Missense_Mutation	NA	A313V	0.32
SKCM	chr3	187731781	Missense_Mutation	NA	A104V	0.45
SKCM	chr3	187724976	Missense_Mutation	novel	H648Y	0.15
SKCM	chr3	187724977	Silent	novel	S647S	0.15
SKCM	chr3	187731798	Silent	NA	R98R	0.15
SKCM	chr3	187729077	Missense_Mutation	novel	A443V	0.38
SKCM	chr3	187729987	Missense_Mutation	rs779270221	R140C	0.29
SKCM	chr3	187726774	Silent	NA	F555F	0.32
SKCM	chr3	187728525	Missense_Mutation	rs137878288	R459C	0.21
SKCM	chr3	187725537	Missense_Mutation	NA	P601S	0.2
SKCM	chr3	187725007	Silent	NA	T637T	0.33
SKCM	chr3	187725066	Missense_Mutation	NA	R618C	0.17
SKCM	chr3	187729784	Silent	NA	L207L	0.38
SKCM	chr3	187725066	Missense_Mutation	NA	R618C	0.18
SKCM	chr3	187726840	Silent	NA	L533L	0.27
SKCM	chr3	187729076	Silent	novel	A443A	0.36
SKCM	chr3	187728470	Missense_Mutation	NA	S477F	0.23
SKCM	chr3	187729155	Missense_Mutation	NA	P417L	0.16
SKCM	chr3	187729777	Missense_Mutation	rs151194132	D210N	0.3
STAD	chr3	187726790	Missense_Mutation	rs147650939	R550H	0.13
STAD	chr3	187729539	Missense_Mutation	rs776120197	R289Q	0.2
STAD	chr3	187722532	Missense_Mutation	NA	A683T	0.28
STAD	chr3	187729555	Missense_Mutation	novel	A284T	0.4
STAD	chr3	187731811	Missense_Mutation	rs768771889	R94Q	0.31
STAD	chr3	187729722	Missense_Mutation	rs755544927	R228Q	0.22
STAD	chr3	187726819	Silent	NA	T540T	0.3
STAD	chr3	187729282	Missense_Mutation	NA	W375R	0.17
STAD	chr3	187729261	Missense_Mutation	novel	V382M	0.15
STAD	chr3	187729932	Missense_Mutation	rs372638471	R158Q	0.22
STAD	chr3	187728524	Missense_Mutation	novel	R459L	0.12
STAD	chr3	187725006	Missense_Mutation	NA	R638C	0.34
THCA	chr3	187725548	Missense_Mutation	NA	S597C	0.21
UCEC	chr3	187722576	Missense_Mutation	novel	R668H	0.14
UCEC	chr3	187731817	Missense_Mutation	NA	T92I	0.48
UCEC	chr3	187729476	Missense_Mutation	NA	D310G	0.39
UCEC	chr3	187725557	Missense_Mutation	NA	R594Q	0.42	zf-C2H2
UCEC	chr3	187731923	Missense_Mutation	novel	F57L	0.24
UCEC	chr3	187726790	Missense_Mutation	rs147650939	R550H	0.54
UCEC	chr3	187731768	Silent	rs766994771	T108T	0.49
UCEC	chr3	187726731	Missense_Mutation	novel	G570S	0.24
UCEC	chr3	187725619	Silent	novel	P573P	0.08
UCEC	chr3	187726862	Missense_Mutation	novel	R526H	0.22
UCEC	chr3	187729774	Nonsense_Mutation	novel	E211*	0.27
UCEC	chr3	187722511	Nonsense_Mutation	novel	Q690*	0.47
UCEC	chr3	187729597	Nonsense_Mutation	novel	R270*	0.42
UCEC	chr3	187729827	Missense_Mutation	novel	A193V	0.44
UCEC	chr3	187725525	Missense_Mutation	NA	E605K	0.26
UCEC	chr3	187728524	Missense_Mutation	rs143522266	R459H	0.12
UCEC	chr3	187725630	Splice_Site	NA	X570_splice	0.19
UCEC	chr3	187729305	Missense_Mutation	NA	P367L	0.13
UCEC	chr3	187729499	Missense_Mutation	NA	E302D	0.38
UCEC	chr3	187729472	Missense_Mutation	NA	E311D	0.12
UCEC	chr3	187729132	Missense_Mutation	novel	L425I	0.32
UCEC	chr3	187729058	Silent	rs780615769	I449I	0.32
UCEC	chr3	187729877	Missense_Mutation	NA	E176D	0.38
UCEC	chr3	187722558	Missense_Mutation	NA	R674Q	0.34
UCEC	chr3	187729465	Missense_Mutation	novel	L314V	0.08
UCEC	chr3	187731864	Silent	novel	P76P	0.22
UCEC	chr3	187721470	3'Flank	rs556072358		0.17
UCEC	chr3	187721567	3'Flank	novel		0.29
UCEC	chr3	187721717	3'Flank	novel		0.35
UCEC	chr3	187731768	Silent	rs766994771	T108T	0.52
UCEC	chr3	187728379	Silent	novel	E507E	0.4
UCEC	chr3	187721431	3'Flank	novel		0.43
UCEC	chr3	187725614	Missense_Mutation	novel	R575H	0.32
UCEC	chr3	187729597	Nonsense_Mutation	novel	R270*	0.47
UCEC	chr3	187728524	Missense_Mutation	rs143522266	R459H	0.48
UCEC	chr3	187721733	3'Flank	novel		0.51
UCEC	chr3	187722205	3'Flank	novel		0.52
UCEC	chr3	187728481	Silent	rs149258247	P473P	0.5
UCEC	chr3	187729310	Missense_Mutation	novel	K365N	0.5
UCEC	chr3	187721898	3'Flank	novel		0.14
UCEC	chr3	187725557	Missense_Mutation	NA	R594Q	0.39	zf-C2H2
UCEC	chr3	187728385	Silent	NA	Q505Q	0.32
UCEC	chr3	187722044	3'Flank	novel		0.31
UCEC	chr3	187745563	5'UTR	novel		0.44
UCEC	chr3	187729274	Silent	novel	K377K	0.4
UCEC	chr3	187729447	Frame_Shift_Ins	NA	*N320Qfs11**	0.21
UCEC	chr3	187721786	3'Flank	novel		0.11
UCEC	chr3	187725557	Missense_Mutation	NA	R594Q	0.17	zf-C2H2
UCEC	chr3	187722531	Missense_Mutation	novel	A683D	0.37
UCEC	chr3	187724939	Splice_Site	novel	X659_splice	0.36
UCEC	chr3	187729261	Missense_Mutation	novel	V382M	0.31
UCEC	chr3	187729927	Missense_Mutation	rs778509539	R160C	0.27
UCEC	chr3	187722243	3'Flank	novel		0.5
UCEC	chr3	187728372	Missense_Mutation	novel	D510Y	0.52
UCEC	chr3	187724970	Nonsense_Mutation	NA	R650*	0.15
UCEC	chr3	187745467	5'UTR	novel		0.31
UCEC	chr3	187745462	5'UTR	novel		0.22
UCEC	chr3	187728482	Frame_Shift_Del	novel	*P473Rfs117**	0.43
UCEC	chr3	187729448	Frame_Shift_Del	novel	*N320Mfs4**	0.31
UCEC	chr3	187722417	3'UTR	novel		0.21
UCEC	chr3	187729178	Silent	rs750915742	T409T	0.38
UCEC	chr3	187731816	Silent	rs748221363	T92T	0.28
UCEC	chr3	187725557	Missense_Mutation	NA	R594Q	0.2	zf-C2H2
UCEC	chr3	187722576	Missense_Mutation	novel	R668H	0.2
UCEC	chr3	187726869	Missense_Mutation	novel	D524N	0.19
UCEC	chr3	187729233	Missense_Mutation	rs769861975	K391R	0.39
UCEC	chr3	187729832	Silent	rs370653196	P191P	0.39
UCEC	chr3	187733611	Missense_Mutation	novel	R28Q	0.2
UCEC	chr3	187733685	Silent	rs776490278	S3S	0.43
UCEC	chr3	187728413	Missense_Mutation	rs375595181	T496M	0.42
UCEC	chr3	187721718	3'Flank	novel		0.33
UCEC	chr3	187722188	3'Flank	novel		0.41
UCEC	chr3	187729376	Silent	rs745836402	S343S	0.39
UCEC	chr3	187729820	Nonsense_Mutation	novel	Y195*	0.41
UCEC	chr3	187731812	Missense_Mutation	rs781532443	R94W	0.44
UCEC	chr3	187729148	Missense_Mutation	novel	E419D	0.36
UCEC	chr3	187729932	Missense_Mutation	rs372638471	R158Q	0.35
UCS	chr3	187733608	Missense_Mutation	novel	D29G	0.31

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
BLCA	AMP	0.4363	0.0018563
KIRC	AMP	0.1174	2.0306e-05
KIRP	AMP	0.3194	0.15981
LUAD	DEL	0.188	0.010111
PAAD	AMP	0.1033	0.16151
SARC	DEL	0.1556	0.0086757
TGCT	AMP	0.2533	7.0307e-05

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.0001	Kaplan-Meier Survival Analysis
STAD	0.036	Kaplan-Meier Survival Analysis
HNSC	0.012	Kaplan-Meier Survival Analysis
SKCM	0.00012	Kaplan-Meier Survival Analysis
LUSC	0.0029	Kaplan-Meier Survival Analysis
COAD	0.04	Kaplan-Meier Survival Analysis
PAAD	0.0044	Kaplan-Meier Survival Analysis
BLCA	0.0029	Kaplan-Meier Survival Analysis
CESC	0.032	Kaplan-Meier Survival Analysis
READ	0.0019	Kaplan-Meier Survival Analysis
LAML	0.043	Kaplan-Meier Survival Analysis
LIHC	0.022	Kaplan-Meier Survival Analysis
OV	0.025	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBDs

Literatures

Expression

Transcripts

Gene Model

Pathway

Phenotype

GWAS

PPI

Ortholog

Gene Ontology

Description

Ensembl ID: ENSG00000113916 (Gene tree)
Gene ID: 604
Gene Symbol: BCL6
Alias: ZBTB27|LAZ3|BCL5|BCL6A|ZNF51
Full Name: BCL6 transcription repressor
Gene Type: protein_coding
Specie: Homo_sapiens
Strand: Minus strand
Length: 24,351 bases
Position: chr3:187,721,377-187,745,727
Accession: 1001
Summary: The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal POZ domain. This protein acts as a sequence-specific repressor of transcription, and has been shown to modulate the transcription of STAT-dependent IL-4 responses of B cells. This protein can interact with a variety of POZ-containing proteins that function as transcription corepressors. This gene is found to be frequently translocated and hypermutated in diffuse large-cell lymphoma (DLCL), and may be involved in the pathogenesis of DLCL. Alternatively spliced transcript variants encoding different protein isoforms have been found for this gene. [provided by RefSeq, Aug 2015]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000232014	zf-C2H2	PF00096.26	3.3e-18	1	3
ENSP00000232014	zf-C2H2	PF00096.26	3.3e-18	2	3
ENSP00000232014	zf-C2H2	PF00096.26	3.3e-18	3	3
ENSP00000384371	zf-C2H2	PF00096.26	3.3e-18	1	3
ENSP00000384371	zf-C2H2	PF00096.26	3.3e-18	2	3
ENSP00000384371	zf-C2H2	PF00096.26	3.3e-18	3	3
ENSP00000413122	zf-C2H2	PF00096.26	1.1e-13	1	3
ENSP00000413122	zf-C2H2	PF00096.26	1.1e-13	2	3
ENSP00000413122	zf-C2H2	PF00096.26	1.1e-13	3	3
ENSP00000479784	zf-C2H2	PF00096.26	1.1e-13	1	3
ENSP00000479784	zf-C2H2	PF00096.26	1.1e-13	2	3
ENSP00000479784	zf-C2H2	PF00096.26	1.1e-13	3	3
ENSP00000232014	zf-met	PF12874.7	2.9e-10	1	2
ENSP00000232014	zf-met	PF12874.7	2.9e-10	2	2
ENSP00000384371	zf-met	PF12874.7	2.9e-10	1	2
ENSP00000384371	zf-met	PF12874.7	2.9e-10	2	2
ENSP00000413122	zf-met	PF12874.7	2.1e-08	1	2
ENSP00000413122	zf-met	PF12874.7	2.1e-08	2	2
ENSP00000479784	zf-met	PF12874.7	2.1e-08	1	2
ENSP00000479784	zf-met	PF12874.7	2.1e-08	2	2

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
20175752	ZEB1 and CtBP form a repressive complex at a distal promoter element of the BCL6 locus.	Biochem J	2010 Apr 14	Papadopoulou V	doi: 10.1042/BJ20091578.
20702579	Defining the epigenetic actions of growth hormone: acute chromatin changes accompany GH-activated gene transcription.	Mol Endocrinol	2010 Oct	Chia DJ	doi: 10.1210/me.2010-0234
20605493	PDCD2, a protein whose expression is repressed by BCL6, induces apoptosis in human cells by activation of the caspase cascade.	Blood Cells Mol Dis	2010 Aug 15	Baron BW	doi: 10.1016/j.bcmd.2010.04.007
26900682	Bcl6 Is Required for Somatic Hypermutation and Gene Conversion in Chicken DT40 Cells.	PLoS One	2016 Feb 22	Williams AM	doi: 10.1371/journal.pone.0149146
30566857	Loss of Transcriptional Repression by BCL6 Confers Insulin Sensitivity in the Setting of Obesity.	Cell Rep	2018 Dec 18	Senagolage MD	doi: 10.1016/j.celrep.2018.11.074.

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000496823	BCL6-210	1138	-	-	- (aa)	-	-
ENST00000406870	BCL6-202	3569	XM_005247694	ENSP00000384371	706 (aa)	XP_005247751	P41182
ENST00000479110	BCL6-208	635	-	-	- (aa)	-	-
ENST00000470319	BCL6-207	526	-	-	- (aa)	-	-
ENST00000450123	BCL6-206	2003	-	ENSP00000413122	650 (aa)	-	P41182
ENST00000419510	BCL6-203	4178	-	ENSP00000398014	55 (aa)	-	A0A0C4DH53
ENST00000621333	BCL6-211	3399	XM_011513062	ENSP00000479784	650 (aa)	XP_011511364	P41182
ENST00000438077	BCL6-205	709	-	ENSP00000414455	104 (aa)	-	C9JL16
ENST00000232014	BCL6-201	2710	-	ENSP00000232014	706 (aa)	-	P41182
ENST00000480458	BCL6-209	342	-	-	- (aa)	-	-
ENST00000430339	BCL6-204	454	-	ENSP00000415574	121 (aa)	-	C9JCS5

Gene Model

Click here to download 's gene model file

Pathway

Pathway ID	Pathway Name	Source
hsa04068	FoxO signaling pathway	KEGG
hsa05202	Transcriptional misregulation in cancer	KEGG

Phenotype

ensgID	Trait	pValue	Pubmed ID
ENSG00000113916	Cholesterol, HDL	4.785e-005	19060910
ENSG00000113916	Hemoglobins	1.776e-005	-
ENSG00000113916	Cell Adhesion Molecules	1.2630000E-005	-
ENSG00000113916	Cell Adhesion Molecules	1.4460000E-005	-
ENSG00000113916	Cholesterol, HDL	1.9080000E-005	-
ENSG00000113916	Eosinophils	3.2720000E-005	-
ENSG00000113916	Platelet Count	2.8170000E-005	-
ENSG00000113916	Urine	1.9911623E-005	-
ENSG00000113916	Platelet Function Tests	1.9748225E-006	-
ENSG00000113916	Platelet Function Tests	1.6030500E-005	-
ENSG00000113916	Platelet Function Tests	1.6030500E-005	-
ENSG00000113916	Child Development Disorders, Pervasive	5.9000000E-005	-
ENSG00000113916	Transforming Growth Factor beta	2.2830000E-006	-
ENSG00000113916	Transforming Growth Factor beta	5.1790000E-005	-
ENSG00000113916	Transforming Growth Factor beta	3.1540000E-005	-
ENSG00000113916	Lung Volume Measurements	5E-7	23284291
ENSG00000113916	dimethylarginine	3E-6	24159190
ENSG00000113916	dimethylarginine	2E-6	24159190
ENSG00000113916	Myopia, Degenerative	5E-7	23049088
ENSG00000113916	Subcutaneous Fat, Abdominal	3E-6	22589738
ENSG00000113916	Lymphoma	3E-13	23749188
ENSG00000113916	Blood Urea Nitrogen	9E-30	22797727
ENSG00000113916	Biomarkers	9E-30	22797727
ENSG00000113916	Diabetes Mellitus, Type 2	6E-9	24509480
ENSG00000113916	Electrocardiography	6E-6	23534349
ENSG00000113916	Glucose	2E-7	25524916
ENSG00000113916	Adipose Tissue	9E-6	22589738
ENSG00000113916	Body Mass Index	9E-6	22589738
ENSG00000113916	Uric Acid	3E-21	21909109
ENSG00000113916	Diabetes Mellitus, Type 2	7E-6	24465431
ENSG00000113916	Obesity	7E-6	24465431
ENSG00000113916	Antineoplastic Agents	7E-6	23648065
ENSG00000113916	Epirubicin	7E-6	23648065
ENSG00000113916	Diabetes Mellitus, Type 2	2E-6	25760438
ENSG00000113916	Uric Acid	1E-11	20139978

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000113916	rs3733017	3	187738921	G	PR interval	23534349	[NR] ms decrease	10.07	EFO_0004462
ENSG00000113916	rs4417855	3	187732340	T	Granulocyte percentage of myeloid white cells	27863252	[0.015-0.029] unit decrease	0.02212151	EFO_0007997
ENSG00000113916	rs3733018	3	187738806	C	Basophil percentage of white cells	27863252	[0.017-0.031] unit decrease	0.0237749	EFO_0007992
ENSG00000113916	rs3733018	3	187738806	C	Basophil percentage of granulocytes	27863252	[0.019-0.033] unit decrease	0.02572174	EFO_0007995

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000113916's network

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy	Species
ENSG00000113916	BCL6	96	71.698	ENSAPOG00000014629	bcl6ab	98	48.387	Acanthochromis_polyacanthus
ENSG00000113916	BCL6	96	88.679	ENSAPOG00000017944	bcl6aa	98	59.720	Acanthochromis_polyacanthus
ENSG00000113916	BCL6	100	100.000	ENSAMEG00000000812	BCL6	100	95.904	Ailuropoda_melanoleuca
ENSG00000113916	BCL6	96	67.925	ENSACIG00000022009	bcl6ab	100	47.486	Amphilophus_citrinellus
ENSG00000113916	BCL6	96	88.679	ENSACIG00000007844	bcl6aa	100	59.358	Amphilophus_citrinellus
ENSG00000113916	BCL6	96	88.679	ENSAOCG00000007113	bcl6aa	98	59.161	Amphiprion_ocellaris
ENSG00000113916	BCL6	96	71.698	ENSAOCG00000015637	bcl6ab	99	49.008	Amphiprion_ocellaris
ENSG00000113916	BCL6	96	88.679	ENSAPEG00000020369	bcl6aa	94	59.860	Amphiprion_percula
ENSG00000113916	BCL6	96	71.698	ENSAPEG00000005418	bcl6ab	97	49.150	Amphiprion_percula
ENSG00000113916	BCL6	100	66.116	ENSATEG00000019949	bcl6ab	98	47.493	Anabas_testudineus
ENSG00000113916	BCL6	96	90.566	ENSATEG00000011384	bcl6aa	98	59.775	Anabas_testudineus
ENSG00000113916	BCL6	87	75.801	ENSACAG00000006666	BCL6	100	75.481	Anolis_carolinensis
ENSG00000113916	BCL6	100	100.000	ENSANAG00000037423	BCL6	100	97.692	Aotus_nancymaae
ENSG00000113916	BCL6	96	71.698	ENSACLG00000009886	bcl6ab	95	94.444	Astatotilapia_calliptera
ENSG00000113916	BCL6	96	88.679	ENSACLG00000024631	bcl6aa	97	100.000	Astatotilapia_calliptera
ENSG00000113916	BCL6	96	86.792	ENSAMXG00000004743	bcl6aa	100	59.091	Astyanax_mexicanus
ENSG00000113916	BCL6	100	100.000	ENSBTAG00000001511	BCL6	100	95.184	Bos_taurus
ENSG00000113916	BCL6	100	100.000	ENSCJAG00000014375	BCL6	100	97.450	Callithrix_jacchus
ENSG00000113916	BCL6	100	100.000	ENSCAFG00000013904	BCL6	99	94.452	Canis_familiaris
ENSG00000113916	BCL6	100	100.000	ENSCAFG00020020000	BCL6	100	96.317	Canis_lupus_dingo
ENSG00000113916	BCL6	100	100.000	ENSCHIG00000026477	BCL6	100	95.042	Capra_hircus
ENSG00000113916	BCL6	100	99.174	ENSTSYG00000032780	BCL6	100	93.231	Carlito_syrichta
ENSG00000113916	BCL6	100	100.000	ENSCAPG00000015510	BCL6	100	95.892	Cavia_aperea
ENSG00000113916	BCL6	100	100.000	ENSCPOG00000004090	BCL6	100	95.892	Cavia_porcellus
ENSG00000113916	BCL6	100	100.000	ENSCCAG00000026327	BCL6	100	97.734	Cebus_capucinus
ENSG00000113916	BCL6	100	100.000	ENSCATG00000037799	BCL6	100	98.584	Cercocebus_atys
ENSG00000113916	BCL6	100	100.000	ENSCLAG00000012339	BCL6	100	95.892	Chinchilla_lanigera
ENSG00000113916	BCL6	100	100.000	ENSCSAG00000009138	BCL6	100	98.446	Chlorocebus_sabaeus
ENSG00000113916	BCL6	98	97.059	ENSCHOG00000013361	BCL6	100	98.889	Choloepus_hoffmanni
ENSG00000113916	BCL6	100	92.562	ENSCPBG00000012754	BCL6	100	80.309	Chrysemys_picta_bellii
ENSG00000113916	BCL6	100	100.000	ENSCANG00000007584	BCL6	100	98.159	Colobus_angolensis_palliatus
ENSG00000113916	BCL6	100	99.174	ENSCGRG00001013589	Bcl6	100	93.503	Cricetulus_griseus_chok1gshd
ENSG00000113916	BCL6	100	99.174	ENSCGRG00000012269	Bcl6	100	93.503	Cricetulus_griseus_crigri
ENSG00000113916	BCL6	100	60.331	ENSCSEG00000017272	bcl6ab	95	90.323	Cynoglossus_semilaevis
ENSG00000113916	BCL6	96	86.792	ENSCSEG00000002879	bcl6aa	100	55.508	Cynoglossus_semilaevis
ENSG00000113916	BCL6	96	88.679	ENSCVAG00000015422	bcl6aa	100	58.217	Cyprinodon_variegatus
ENSG00000113916	BCL6	96	64.151	ENSCVAG00000005127	bcl6ab	96	57.592	Cyprinodon_variegatus
ENSG00000113916	BCL6	96	88.679	ENSDARG00000070864	bcl6aa	98	60.526	Danio_rerio
ENSG00000113916	BCL6	96	71.698	ENSDARG00000069295	bcl6ab	91	76.884	Danio_rerio
ENSG00000113916	BCL6	100	100.000	ENSDNOG00000004306	BCL6	84	89.438	Dasypus_novemcinctus
ENSG00000113916	BCL6	100	100.000	ENSDORG00000005608	Bcl6	100	94.901	Dipodomys_ordii
ENSG00000113916	BCL6	100	98.347	ENSETEG00000014830	BCL6	100	91.076	Echinops_telfairi
ENSG00000113916	BCL6	100	99.174	ENSEASG00005014114	BCL6	100	96.034	Equus_asinus_asinus
ENSG00000113916	BCL6	100	99.174	ENSECAG00000004556	BCL6	100	96.000	Equus_caballus
ENSG00000113916	BCL6	100	99.174	ENSEEUG00000000344	BCL6	91	100.000	Erinaceus_europaeus
ENSG00000113916	BCL6	100	69.421	ENSELUG00000023065	bcl6ab	98	51.888	Esox_lucius
ENSG00000113916	BCL6	96	88.679	ENSELUG00000008285	bcl6aa	100	54.470	Esox_lucius
ENSG00000113916	BCL6	100	100.000	ENSFCAG00000006810	BCL6	100	96.459	Felis_catus
ENSG00000113916	BCL6	100	96.154	ENSFALG00000007407	BCL6	100	78.711	Ficedula_albicollis
ENSG00000113916	BCL6	100	98.347	ENSFDAG00000007856	BCL6	100	88.333	Fukomys_damarensis
ENSG00000113916	BCL6	100	60.331	ENSFHEG00000017119	bcl6ab	90	60.260	Fundulus_heteroclitus
ENSG00000113916	BCL6	96	88.679	ENSFHEG00000009639	bcl6aa	96	56.886	Fundulus_heteroclitus
ENSG00000113916	BCL6	87	93.750	ENSGMOG00000019214	bcl6aa	97	93.478	Gadus_morhua
ENSG00000113916	BCL6	100	69.421	ENSGMOG00000018097	bcl6ab	61	74.242	Gadus_morhua
ENSG00000113916	BCL6	100	96.154	ENSGALG00000007357	BCL6	100	78.903	Gallus_gallus
ENSG00000113916	BCL6	96	66.038	ENSGAFG00000007358	bcl6ab	99	46.648	Gambusia_affinis
ENSG00000113916	BCL6	96	88.679	ENSGAFG00000017288	bcl6aa	100	58.182	Gambusia_affinis
ENSG00000113916	BCL6	96	88.679	ENSGACG00000003839	bcl6aa	100	59.388	Gasterosteus_aculeatus
ENSG00000113916	BCL6	100	69.091	ENSGACG00000015981	bcl6ab	98	45.175	Gasterosteus_aculeatus
ENSG00000113916	BCL6	100	92.562	ENSGAGG00000001257	BCL6	100	80.169	Gopherus_agassizii
ENSG00000113916	BCL6	100	100.000	ENSGGOG00000026549	BCL6	100	99.717	Gorilla_gorilla
ENSG00000113916	BCL6	96	71.698	ENSHBUG00000006521	-	98	48.101	Haplochromis_burtoni
ENSG00000113916	BCL6	96	88.679	ENSHBUG00000013427	bcl6aa	100	59.664	Haplochromis_burtoni
ENSG00000113916	BCL6	100	99.174	ENSHGLG00000016440	BCL6	100	95.042	Heterocephalus_glaber_female
ENSG00000113916	BCL6	100	99.174	ENSHGLG00100018263	BCL6	100	94.901	Heterocephalus_glaber_male
ENSG00000113916	BCL6	96	66.038	ENSHCOG00000020446	bcl6ab	99	46.220	Hippocampus_comes
ENSG00000113916	BCL6	92	55.789	ENSHCOG00000014038	bcl6aa	97	56.495	Hippocampus_comes
ENSG00000113916	BCL6	96	86.792	ENSIPUG00000010505	bcl6	99	61.367	Ictalurus_punctatus
ENSG00000113916	BCL6	96	66.038	ENSIPUG00000013251	bcl6ab	60	76.974	Ictalurus_punctatus
ENSG00000113916	BCL6	100	100.000	ENSSTOG00000000843	BCL6	100	96.176	Ictidomys_tridecemlineatus
ENSG00000113916	BCL6	100	99.174	ENSJJAG00000017558	Bcl6	100	93.927	Jaculus_jaculus
ENSG00000113916	BCL6	96	88.679	ENSKMAG00000014942	bcl6aa	100	58.396	Kryptolebias_marmoratus
ENSG00000113916	BCL6	96	69.811	ENSKMAG00000002087	bcl6ab	100	47.083	Kryptolebias_marmoratus
ENSG00000113916	BCL6	96	71.698	ENSLBEG00000008064	bcl6ab	98	47.117	Labrus_bergylta
ENSG00000113916	BCL6	96	86.792	ENSLBEG00000025751	bcl6aa	98	59.693	Labrus_bergylta
ENSG00000113916	BCL6	96	62.963	ENSLACG00000013447	-	98	47.273	Latimeria_chalumnae
ENSG00000113916	BCL6	98	87.037	ENSLOCG00000005212	bcl6aa	98	61.964	Lepisosteus_oculatus
ENSG00000113916	BCL6	100	100.000	ENSLAFG00000012300	BCL6	100	95.056	Loxodonta_africana
ENSG00000113916	BCL6	100	100.000	ENSMFAG00000001360	BCL6	100	98.442	Macaca_fascicularis
ENSG00000113916	BCL6	100	100.000	ENSMMUG00000009198	BCL6	100	98.442	Macaca_mulatta
ENSG00000113916	BCL6	100	100.000	ENSMNEG00000034068	BCL6	100	98.442	Macaca_nemestrina
ENSG00000113916	BCL6	100	100.000	ENSMLEG00000036711	BCL6	100	98.584	Mandrillus_leucophaeus
ENSG00000113916	BCL6	96	69.811	ENSMAMG00000003320	bcl6ab	96	93.333	Mastacembelus_armatus
ENSG00000113916	BCL6	96	86.792	ENSMAMG00000010010	bcl6aa	100	57.380	Mastacembelus_armatus
ENSG00000113916	BCL6	96	88.679	ENSMZEG00005008634	bcl6aa	100	59.664	Maylandia_zebra
ENSG00000113916	BCL6	96	71.698	ENSMZEG00005005450	bcl6ab	95	93.333	Maylandia_zebra
ENSG00000113916	BCL6	100	96.154	ENSMGAG00000007602	BCL6	100	78.481	Meleagris_gallopavo
ENSG00000113916	BCL6	100	99.174	ENSMAUG00000010580	Bcl6	100	94.068	Mesocricetus_auratus
ENSG00000113916	BCL6	100	99.174	ENSMICG00000049071	BCL6	100	96.459	Microcebus_murinus
ENSG00000113916	BCL6	100	100.000	ENSMOCG00000002694	Bcl6	100	94.068	Microtus_ochrogaster
ENSG00000113916	BCL6	100	66.116	ENSMMOG00000018109	bcl6ab	97	48.345	Mola_mola
ENSG00000113916	BCL6	96	88.679	ENSMMOG00000005607	bcl6aa	100	57.806	Mola_mola
ENSG00000113916	BCL6	96	86.792	ENSMALG00000016507	bcl6aa	100	59.104	Monopterus_albus
ENSG00000113916	BCL6	96	64.151	ENSMALG00000006363	bcl6ab	99	47.265	Monopterus_albus
ENSG00000113916	BCL6	100	98.077	MGP_CAROLIEiJ_G0020622	Bcl6	100	94.484	Mus_caroli
ENSG00000113916	BCL6	100	99.038	ENSMUSG00000022508	Bcl6	100	94.625	Mus_musculus
ENSG00000113916	BCL6	100	99.038	MGP_PahariEiJ_G0016327	Bcl6	100	91.020	Mus_pahari
ENSG00000113916	BCL6	100	99.038	MGP_SPRETEiJ_G0021518	Bcl6	100	94.625	Mus_spretus
ENSG00000113916	BCL6	100	100.000	ENSMPUG00000003415	BCL6	100	95.467	Mustela_putorius_furo
ENSG00000113916	BCL6	100	100.000	ENSMLUG00000012905	BCL6	100	94.774	Myotis_lucifugus
ENSG00000113916	BCL6	100	100.000	ENSNGAG00000010532	-	100	95.184	Nannospalax_galili
ENSG00000113916	BCL6	92	80.435	ENSNGAG00000023172	-	96	70.903	Nannospalax_galili
ENSG00000113916	BCL6	96	88.679	ENSNBRG00000012880	bcl6aa	96	59.664	Neolamprologus_brichardi
ENSG00000113916	BCL6	96	71.698	ENSNBRG00000003990	bcl6ab	98	47.465	Neolamprologus_brichardi
ENSG00000113916	BCL6	100	100.000	ENSNLEG00000006705	BCL6	100	98.584	Nomascus_leucogenys
ENSG00000113916	BCL6	100	97.521	ENSMEUG00000004411	BCL6	100	80.057	Notamacropus_eugenii
ENSG00000113916	BCL6	100	100.000	ENSOPRG00000005797	BCL6	100	92.635	Ochotona_princeps
ENSG00000113916	BCL6	100	100.000	ENSODEG00000000516	BCL6	100	95.467	Octodon_degus
ENSG00000113916	BCL6	96	71.698	ENSONIG00000010655	bcl6ab	100	48.169	Oreochromis_niloticus
ENSG00000113916	BCL6	96	88.679	ENSONIG00000019322	bcl6aa	98	59.664	Oreochromis_niloticus
ENSG00000113916	BCL6	100	95.192	ENSOANG00000000872	BCL6	100	84.831	Ornithorhynchus_anatinus
ENSG00000113916	BCL6	100	100.000	ENSOCUG00000005429	BCL6	100	94.915	Oryctolagus_cuniculus
ENSG00000113916	BCL6	96	88.679	ENSORLG00000015589	bcl6aa	97	59.860	Oryzias_latipes
ENSG00000113916	BCL6	96	67.925	ENSORLG00000004563	bcl6ab	96	45.768	Oryzias_latipes
ENSG00000113916	BCL6	96	67.925	ENSORLG00020003678	bcl6ab	96	45.780	Oryzias_latipes_hni
ENSG00000113916	BCL6	96	88.679	ENSORLG00020000591	bcl6aa	100	59.860	Oryzias_latipes_hni
ENSG00000113916	BCL6	96	88.679	ENSORLG00015016193	bcl6aa	100	58.270	Oryzias_latipes_hsok
ENSG00000113916	BCL6	96	67.925	ENSORLG00015006830	bcl6ab	96	45.624	Oryzias_latipes_hsok
ENSG00000113916	BCL6	96	88.679	ENSOMEG00000002918	bcl6aa	98	60.028	Oryzias_melastigma
ENSG00000113916	BCL6	80	93.496	ENSOMEG00000016018	bcl6ab	96	45.946	Oryzias_melastigma
ENSG00000113916	BCL6	100	99.174	ENSOGAG00000007638	BCL6	100	95.763	Otolemur_garnettii
ENSG00000113916	BCL6	100	100.000	ENSOARG00000020487	BCL6	99	89.943	Ovis_aries
ENSG00000113916	BCL6	100	100.000	ENSPPAG00000028978	BCL6	100	99.717	Pan_paniscus
ENSG00000113916	BCL6	100	100.000	ENSPPRG00000000750	BCL6	100	96.601	Panthera_pardus
ENSG00000113916	BCL6	100	100.000	ENSPTIG00000022010	BCL6	100	96.459	Panthera_tigris_altaica
ENSG00000113916	BCL6	100	100.000	ENSPTRG00000015728	BCL6	100	99.717	Pan_troglodytes
ENSG00000113916	BCL6	100	100.000	ENSPANG00000017677	BCL6	100	95.763	Papio_anubis
ENSG00000113916	BCL6	100	76.033	ENSPKIG00000025387	bcl6aa	99	56.328	Paramormyrops_kingsleyae
ENSG00000113916	BCL6	96	83.019	ENSPKIG00000006988	BCL6	98	59.835	Paramormyrops_kingsleyae
ENSG00000113916	BCL6	100	95.192	ENSPSIG00000014529	BCL6	100	79.747	Pelodiscus_sinensis
ENSG00000113916	BCL6	100	59.504	ENSPMGG00000009399	bcl6ab	100	43.644	Periophthalmus_magnuspinnatus
ENSG00000113916	BCL6	96	86.792	ENSPMGG00000018517	bcl6aa	100	59.021	Periophthalmus_magnuspinnatus
ENSG00000113916	BCL6	100	100.000	ENSPEMG00000020985	Bcl6	100	94.774	Peromyscus_maniculatus_bairdii
ENSG00000113916	BCL6	100	98.347	ENSPCIG00000025261	BCL6	98	83.099	Phascolarctos_cinereus
ENSG00000113916	BCL6	96	88.679	ENSPFOG00000001561	bcl6aa	94	58.240	Poecilia_formosa
ENSG00000113916	BCL6	96	67.925	ENSPFOG00000016628	bcl6ab	99	47.226	Poecilia_formosa
ENSG00000113916	BCL6	96	67.925	ENSPLAG00000013751	bcl6ab	94	60.156	Poecilia_latipinna
ENSG00000113916	BCL6	96	88.679	ENSPLAG00000000392	bcl6aa	98	57.542	Poecilia_latipinna
ENSG00000113916	BCL6	96	88.679	ENSPMEG00000019774	bcl6aa	100	56.153	Poecilia_mexicana
ENSG00000113916	BCL6	96	67.925	ENSPMEG00000004153	bcl6ab	99	47.511	Poecilia_mexicana
ENSG00000113916	BCL6	96	88.679	ENSPREG00000016542	bcl6aa	100	57.961	Poecilia_reticulata
ENSG00000113916	BCL6	96	67.925	ENSPREG00000007006	bcl6ab	94	60.156	Poecilia_reticulata
ENSG00000113916	BCL6	100	100.000	ENSPPYG00000014395	BCL6	100	99.575	Pongo_abelii
ENSG00000113916	BCL6	100	100.000	ENSPCAG00000007666	BCL6	100	100.000	Procavia_capensis
ENSG00000113916	BCL6	100	99.174	ENSPCOG00000016145	BCL6	100	96.884	Propithecus_coquereli
ENSG00000113916	BCL6	100	99.174	ENSPVAG00000012338	BCL6	100	94.476	Pteropus_vampyrus
ENSG00000113916	BCL6	96	69.811	ENSPNYG00000000343	bcl6ab	100	47.887	Pundamilia_nyererei
ENSG00000113916	BCL6	96	88.679	ENSPNYG00000019267	bcl6aa	100	59.664	Pundamilia_nyererei
ENSG00000113916	BCL6	96	86.792	ENSPNAG00000005219	bcl6aa	100	60.610	Pygocentrus_nattereri
ENSG00000113916	BCL6	96	71.698	ENSPNAG00000017299	bcl6ab	62	90.833	Pygocentrus_nattereri
ENSG00000113916	BCL6	100	99.174	ENSRNOG00000001843	Bcl6	100	95.050	Rattus_norvegicus
ENSG00000113916	BCL6	100	100.000	ENSRBIG00000042034	BCL6	100	98.300	Rhinopithecus_bieti
ENSG00000113916	BCL6	100	100.000	ENSRROG00000024075	BCL6	100	98.300	Rhinopithecus_roxellana
ENSG00000113916	BCL6	100	100.000	ENSSBOG00000026320	BCL6	100	97.734	Saimiri_boliviensis_boliviensis
ENSG00000113916	BCL6	100	98.347	ENSSHAG00000013935	BCL6	100	83.333	Sarcophilus_harrisii
ENSG00000113916	BCL6	96	97.849	ENSSFOG00015006752	bcl6aa	97	97.849	Scleropages_formosus
ENSG00000113916	BCL6	96	81.132	ENSSFOG00015012599	BCL6	100	60.388	Scleropages_formosus
ENSG00000113916	BCL6	96	69.811	ENSSMAG00000007737	bcl6ab	99	48.169	Scophthalmus_maximus
ENSG00000113916	BCL6	96	86.792	ENSSMAG00000001102	bcl6aa	99	59.777	Scophthalmus_maximus
ENSG00000113916	BCL6	96	86.792	ENSSDUG00000021587	bcl6aa	99	59.720	Seriola_dumerili
ENSG00000113916	BCL6	96	69.811	ENSSDUG00000010653	bcl6ab	100	47.874	Seriola_dumerili
ENSG00000113916	BCL6	96	69.811	ENSSLDG00000015676	bcl6ab	100	47.383	Seriola_lalandi_dorsalis
ENSG00000113916	BCL6	96	86.792	ENSSLDG00000002495	bcl6aa	100	57.815	Seriola_lalandi_dorsalis
ENSG00000113916	BCL6	100	94.231	ENSSPUG00000011070	BCL6	98	92.929	Sphenodon_punctatus
ENSG00000113916	BCL6	96	71.698	ENSSPAG00000001985	bcl6ab	98	49.369	Stegastes_partitus
ENSG00000113916	BCL6	96	88.679	ENSSPAG00000016898	bcl6aa	98	60.000	Stegastes_partitus
ENSG00000113916	BCL6	100	100.000	ENSSSCG00000011810	BCL6	100	95.042	Sus_scrofa
ENSG00000113916	BCL6	100	96.154	ENSTGUG00000009413	BCL6	100	79.747	Taeniopygia_guttata
ENSG00000113916	BCL6	100	59.504	ENSTRUG00000001788	bcl6ab	100	46.414	Takifugu_rubripes
ENSG00000113916	BCL6	96	88.679	ENSTRUG00000002214	bcl6	97	100.000	Takifugu_rubripes
ENSG00000113916	BCL6	96	66.038	ENSTNIG00000007834	bcl6ab	100	46.657	Tetraodon_nigroviridis
ENSG00000113916	BCL6	96	84.906	ENSTNIG00000013771	bcl6aa	100	59.135	Tetraodon_nigroviridis
ENSG00000113916	BCL6	100	99.174	ENSTBEG00000009526	BCL6	100	90.652	Tupaia_belangeri
ENSG00000113916	BCL6	100	100.000	ENSTTRG00000017230	BCL6	100	93.059	Tursiops_truncatus
ENSG00000113916	BCL6	100	100.000	ENSUAMG00000011599	BCL6	100	96.317	Ursus_americanus
ENSG00000113916	BCL6	100	100.000	ENSUMAG00000004023	BCL6	100	96.317	Ursus_maritimus
ENSG00000113916	BCL6	100	100.000	ENSVVUG00000013355	BCL6	100	96.176	Vulpes_vulpes
ENSG00000113916	BCL6	96	79.310	ENSXETG00000019779	bcl6	99	67.422	Xenopus_tropicalis
ENSG00000113916	BCL6	96	88.679	ENSXCOG00000006090	bcl6aa	98	57.762	Xiphophorus_couchianus
ENSG00000113916	BCL6	96	88.679	ENSXMAG00000016456	bcl6aa	94	58.462	Xiphophorus_maculatus
ENSG00000113916	BCL6	96	66.038	ENSXMAG00000004454	bcl6ab	99	47.151	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000122	negative regulation of transcription by RNA polymerase II	11929873.15577913.	IDA	Process
GO:0000902	cell morphogenesis	-	IEA	Process
GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding	21873635.	IBA	Function
GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	-	ISA	Function
GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	19274049.	NAS	Function
GO:0001161	intronic transcription regulatory region sequence-specific DNA binding	-	IEA	Function
GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	21873635.	IBA	Function
GO:0001953	negative regulation of cell-matrix adhesion	-	IEA	Process
GO:0002467	germinal center formation	-	IEA	Process
GO:0002634	regulation of germinal center formation	7795255.	NAS	Process
GO:0002903	negative regulation of B cell apoptotic process	15577913.	NAS	Process
GO:0003677	DNA binding	21873635.	IBA	Function
GO:0003682	chromatin binding	12097386.	IDA	Function
GO:0003700	DNA-binding transcription factor activity	15577913.	IMP	Function
GO:0005515	protein binding	10898795.12590135.16147992.16819511.21390126.22113614.25416956.27107012.	IPI	Function
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005634	nucleus	7795255.10898795.11929873.	IDA	Component
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005657	replication fork	10490843.	IDA	Component
GO:0005794	Golgi apparatus	-	IDA	Component
GO:0006954	inflammatory response	-	IEA	Process
GO:0006974	cellular response to DNA damage stimulus	15577913.	IDA	Process
GO:0007266	Rho protein signal transduction	-	IEA	Process
GO:0007283	spermatogenesis	-	IEA	Process
GO:0008104	protein localization	-	IEA	Process
GO:0008285	negative regulation of cell proliferation	-	IEA	Process
GO:0019221	cytokine-mediated signaling pathway	-	TAS	Process
GO:0030036	actin cytoskeleton organization	-	IEA	Process
GO:0030183	B cell differentiation	-	IEA	Process
GO:0030308	negative regulation of cell growth	10490843.	IDA	Process
GO:0030890	positive regulation of B cell proliferation	-	IEA	Process
GO:0031065	positive regulation of histone deacetylation	-	IEA	Process
GO:0031490	chromatin DNA binding	-	IEA	Function
GO:0032764	negative regulation of mast cell cytokine production	-	IEA	Process
GO:0035024	negative regulation of Rho protein signal transduction	-	IEA	Process
GO:0042092	type 2 immune response	21873635.	IBA	Process
GO:0042127	regulation of cell proliferation	21873635.	IBA	Process
GO:0042802	identical protein binding	25416956.	IPI	Function
GO:0042981	regulation of apoptotic process	-	TAS	Process
GO:0043065	positive regulation of apoptotic process	10490843.	IDA	Process
GO:0043087	regulation of GTPase activity	-	IEA	Process
GO:0043380	regulation of memory T cell differentiation	-	IEA	Process
GO:0043565	sequence-specific DNA binding	15577913.	IDA	Function
GO:0045591	positive regulation of regulatory T cell differentiation	22387553.	IMP	Process
GO:0045629	negative regulation of T-helper 2 cell differentiation	-	IEA	Process
GO:0045666	positive regulation of neuron differentiation	-	IEA	Process
GO:0045746	negative regulation of Notch signaling pathway	-	IEA	Process
GO:0045892	negative regulation of transcription, DNA-templated	15577913.	IMP	Process
GO:0045892	negative regulation of transcription, DNA-templated	9135990.	NAS	Process
GO:0046872	metal ion binding	-	IEA	Function
GO:0048294	negative regulation of isotype switching to IgE isotypes	-	IEA	Process
GO:0048821	erythrocyte development	-	IEA	Process
GO:0050727	regulation of inflammatory response	21873635.	IBA	Process
GO:0050776	regulation of immune response	16455075.	NAS	Process
GO:0051272	positive regulation of cellular component movement	-	IEA	Process
GO:1903464	negative regulation of mitotic cell cycle DNA replication	10490843.	NAS	Process
GO:2000773	negative regulation of cellular senescence	-	IEA	Process

EuRBPDB

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Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBDs

Literatures

Expression

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GWAS

PPI

Ortholog

Gene Ontology

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Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.