EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
25847991	Glucocorticoid receptor regulates accurate chromosome segregation and is associated with malignancy.	Proc Natl Acad Sci U S A	2015 Apr 28	Matthews LC	doi: 10.1073/pnas.1411356112
21474440	Glucocorticoid-independent repression of tumor necrosis factor (TNF) alpha-stimulated interleukin (IL)-6 expression by the glucocorticoid receptor: a potential mechanism for protection against an excessive inflammatory response.	J Biol Chem	2011 Jun 3	Verhoog NJ	doi: 10.1074/jbc.M110.193672
24622770	Frequent promoter hypermethylation and expression reduction of the glucocorticoid receptor gene in breast tumors.	Epigenetics	2014 Jun	Nesset KA	doi: 10.4161/epi.28484
27253665	Testicular Receptor-4: Novel Regulator of Glucocorticoid Resistance.	J Clin Endocrinol Metab	2016 Aug	Zhang D	doi: 10.1210/jc.2016-1379
27060168	Haploinsufficiency for NR3C1, the gene encoding the glucocorticoid receptor, in blastic plasmacytoid dendritic cell neoplasms.	Blood	2016 Jun 16	Emadali A	doi: 10.1182/blood-2015-09-671040
29904891	α-Viniferin activates autophagic apoptosis and cell death by reducing glucocorticoid receptor expression in castration-resistant prostate cancer cells.	Med Oncol	2018 Jun 15	Cheng K	doi: 10.1007/s12032-018-1163-y.
16806572	Glucocorticoid receptor expression in advanced non-small cell lung cancer: clinicopathological correlation and in vitro effect of glucocorticoid on cell growth and chemosensitivity.	Lung Cancer	2006 Sep	Lu YS	-
24736075	Glucocorticoid receptor status is a principal determinant of variability in the sensitivity of non-small-cell lung cancer cells to pemetrexed.	J Thorac Oncol	2014 Apr	Patki M	doi: 10.1097/JTO.0000000000000111.
15590693	Glucocorticoid receptor-induced MAPK phosphatase-1 (MPK-1) expression inhibits paclitaxel-associated MAPK activation and contributes to breast cancer cell survival.	J Biol Chem	2005 Feb 11	Wu W	-
17496926	Glucocorticoid receptor overexpression exerts an antisurvival effect on human small cell lung cancer cells.	Oncogene	2007 Nov 1	Sommer P	-
21868756	Activation of the glucocorticoid receptor is associated with poor prognosis in estrogen receptor-negative breast cancer.	Cancer Res	2011 Oct 15	Pan D	doi: 10.1158/0008-5472.CAN-11-0362
21984896	Loss of glucocorticoid receptor expression by DNA methylation prevents glucocorticoid induced apoptosis in human small cell lung cancer cells.	PLoS One	2011	Kay P	doi: 10.1371/journal.pone.0024839
17512111	Progesterone, glucocorticoid, but not estrogen receptor mRNA is altered in breast cancer stroma.	Cancer Lett	2007 Sep 18	Smith RA	-
19875955	Estrogen receptor, progesterone receptor, and glucocorticoid receptor expression in normal breast tissue, breast in situ carcinoma, and invasive breast cancer.	Appl Immunohistochem Mol Morphol	2010 May	Buxant F	doi: 10.1097/PAI.0b013e3181c10180.
18668364	Glucocorticoid receptor expression in breast cancer associates with older patient age.	Breast Cancer Res Treat	2009 Aug	Belova L	doi: 10.1007/s10549-008-0136-9
24615402	Glucocorticoid receptor activity contributes to resistance to androgen-targeted therapy in prostate cancer.	Horm Cancer	2014 Apr	Isikbay M	doi: 10.1007/s12672-014-0173-2
27179949	Genetic variants in chromatin-remodeling pathway associated with lung cancer risk in a Chinese population.	Gene	2016 Aug 10	Geng L	doi: 10.1016/j.gene.2016.05.013
25043756	Dihydrotestosterone enhances castration-resistant prostate cancer cell proliferation through STAT5 activation via glucocorticoid receptor pathway.	Prostate	2014 Sep	Song C	doi: 10.1002/pros.22841
17952860	Glucocorticoid receptor changes its cellular location with breast cancer development.	Histol Histopathol	2008 Jan	Conde I	doi: 10.14670/HH-23.77.
21078539	Glucocorticoid receptor signaling and prostate cancer.	Cancer Lett	2011 Mar 1	Kassi E	doi: 10.1016/j.canlet.2010.10.020.
24629067	The variant E233G of the RAD51D gene could be a low-penetrance allele in high-risk breast cancer families without BRCA1/2 mutations.	Int J Cancer	2004 Jul 20	Rodr??guez-L??pez R	-
27484907	Epigenetic and Glucocorticoid Receptor-Mediated Regulation of Glutathione Peroxidase 3 in Lung Cancer Cells.	Mol Cells	2016 Aug 31	An BC	doi: 10.14348/molcells.2016.0164

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
ACC	chr5	143282616	Silent	rs775051931	N711N	0.33
BLCA	chr5	143400664	Missense_Mutation	novel	R59Q	0.13
BLCA	chr5	143400502	Missense_Mutation	rs764178904	S113F	0.41
BLCA	chr5	143300690	Silent	novel	N514N	0.46
BLCA	chr5	143281853	3'UTR	rs761674033		0.24
BLCA	chr5	143281845	3'UTR	novel		0.39
BLCA	chr5	143400840	5'UTR	novel		0.48
BLCA	chr5	143400539	Missense_Mutation	novel	D101H	0.47
BLCA	chr5	143300760	Missense_Mutation	NA	R491Q	0.25
BLCA	chr5	143300760	Missense_Mutation	NA	R491Q	0.27
BLCA	chr5	143400279	Missense_Mutation	rs750705576	D187E	0.16
BLCA	chr5	143295502	Missense_Mutation	novel	E661K	0.18
BRCA	chr5	143399935	Missense_Mutation	NA	C302F	0.08
BRCA	chr5	143300547	Missense_Mutation	rs761295829	T562M	0.29
BRCA	chr5	143400589	Missense_Mutation	NA	L84R	0.37
BRCA	chr5	143310160	Nonsense_Mutation	NA	R469*	0.2
BRCA	chr5	143281972	Frame_Shift_Del	novel	*E751Rfs3**	0.06
CESC	chr5	143281721	3'UTR	novel		0.2
CESC	chr5	143400661	Missense_Mutation	novel	R60T	0.36
CESC	chr5	143281413	3'UTR	novel		0.53
CESC	chr5	143300558	Silent	novel	R558R	0.36
CESC	chr5	143279367	3'UTR	novel		0.36
CESC	chr5	143400683	Missense_Mutation	NA	Q53E	0.27
CESC	chr5	143279294	3'UTR	novel		0.4
CESC	chr5	143400266	Missense_Mutation	NA	D192H	0.25
CESC	chr5	143279791	3'UTR	novel		0.31
CESC	chr5	143279891	3'UTR	novel		0.17
CESC	chr5	143400499	Missense_Mutation	rs756635644	S114L	0.1
CESC	chr5	143400592	Missense_Mutation	NA	S83L	0.22
CHOL	chr5	143281188	3'UTR	novel		0.28
CHOL	chr5	143281480	3'UTR	novel		0.3
COAD	chr5	143400814	Missense_Mutation	NA	P9H	0.4
COAD	chr5	143400154	Missense_Mutation	NA	A229V	0.29
COAD	chr5	143300660	Silent	rs138266608	T524T	0.47
COAD	chr5	143281853	3'UTR	rs761674033		0.54
COAD	chr5	143314036	Silent	NA	G439G	0.37
COAD	chr5	143399809	Missense_Mutation	rs750359967	Q344R	0.24
COAD	chr5	143399988	Silent	NA	I284I	0.23
COAD	chr5	143298690	Frame_Shift_Ins	novel	*A624Cfs3**	0.25
COAD	chr5	143281853	3'UTR	rs761674033		0.16
COAD	chr5	143281976	Silent	novel	F749F	0.54
COAD	chr5	143310160	Nonsense_Mutation	NA	R469*	0.39
COAD	chr5	143281955	Silent	novel	I756I	0.29
COAD	chr5	143400175	Missense_Mutation	NA	N222T	0.24
COAD	chr5	143400339	Silent	NA	Q167Q	0.12
COAD	chr5	143399874	Frame_Shift_Ins	novel	*V324Nfs14**	0.05
ESCA	chr5	143279263	3'UTR	rs115618248		0.24
ESCA	chr5	143279873	3'UTR	novel		0.37
GBM	chr5	143310160	Nonsense_Mutation	NA	R469*	0.18
GBM	chr5	143400569	Missense_Mutation	novel	G91R	0.1
GBM	chr5	143400720	Missense_Mutation	novel	K40N	0.06
GBM	chr5	143400845	5'UTR	novel		0.1
HNSC	chr5	143281794	3'UTR	novel		0.1
HNSC	chr5	143399917	Missense_Mutation	novel	G308A	0.08
HNSC	chr5	143281829	3'UTR	novel		0.1
HNSC	chr5	143400602	In_Frame_Del	novel	P76_K80delinsQ	0.08
HNSC	chr5	143295481	Missense_Mutation	novel	T668P	0.17
HNSC	chr5	143300587	Missense_Mutation	novel	D549N	0.16
KICH	chr5	143281999	Missense_Mutation	novel	D742N	0.28
KIRC	chr5	143400048	Silent	NA	V264V	0.14
KIRP	chr5	143295486	Frame_Shift_Del	novel	*M666Efs11**	0.38
KIRP	chr5	143281759	3'UTR	novel		0.08
KIRP	chr5	143281760	3'UTR	novel		0.2
KIRP	chr5	143282578	Missense_Mutation	novel	S724C	0.41
LGG	chr5	143400085	Missense_Mutation	NA	D252G	0.07
LGG	chr5	143282578	Missense_Mutation	NA	S724Y	0.34
LGG	chr5	143400480	Silent	novel	K120K	0.39
LIHC	chr5	143300489	Silent	NA	I581I	0.51
LIHC	chr5	143300680	Nonsense_Mutation	novel	K518*	0.16
LIHC	chr5	143279358	3'UTR	novel		0.41
LUAD	chr5	143400776	Nonsense_Mutation	novel	E22*	0.31
LUAD	chr5	143400234	Silent	NA	G202G	0.19
LUAD	chr5	143295518	Missense_Mutation	novel	R655S	0.25
LUAD	chr5	143400592	Missense_Mutation	NA	S83L	0.05
LUAD	chr5	143282034	Missense_Mutation	novel	E730G	0.1
LUAD	chr5	143400433	Missense_Mutation	NA	P136L	0.2
LUAD	chr5	143300709	Nonsense_Mutation	novel	S508*	0.1
LUAD	chr5	143300566	Missense_Mutation	novel	T556S	0.1
LUAD	chr5	143400621	Silent	novel	A73A	0.76
LUAD	chr5	143400287	Missense_Mutation	novel	T185S	0.08
LUAD	chr5	143399935	Missense_Mutation	NA	C302F	0.33
LUAD	chr5	143282723	Missense_Mutation	novel	P676S	0.13
LUSC	chr5	143310159	Missense_Mutation	NA	R469Q	0.28
LUSC	chr5	143300660	Silent	NA	T524T	0.55
LUSC	chr5	143400383	Missense_Mutation	rs766706619	E153K	0.47
LUSC	chr5	143310135	Missense_Mutation	rs104893913	R477H	0.33
LUSC	chr5	143300574	Missense_Mutation	novel	P553R	0.22
OV	chr5	143281972	Missense_Mutation	NA	E751K	0.09
OV	chr5	143281908	Missense_Mutation	NA	L772P	0.64
PAAD	chr5	143295472	Missense_Mutation	novel	L671I	0.2
PAAD	chr5	143314142	Missense_Mutation	novel	S404Y	0.19
READ	chr5	143310130	Nonsense_Mutation	NA	R479*	0.2
READ	chr5	143399776	Missense_Mutation	novel	P355Q	0.08
READ	chr5	143400689	Missense_Mutation	NA	A51T	0.24
READ	chr5	143400509	Missense_Mutation	novel	S111C	0.17
READ	chr5	143281892	Silent	NA	K777K	0.27
READ	chr5	143279327	3'UTR	novel		0.5
READ	chr5	143300625	Missense_Mutation	novel	L536S	0.06
READ	chr5	143300704	Nonsense_Mutation	novel	E510*	0.4
READ	chr5	143399988	Silent	NA	I284I	0.4
SARC	chr5	143281480	3'UTR	novel		0.27
SKCM	chr5	143399869	Missense_Mutation	NA	V324E	0.46
SKCM	chr5	143310168	Missense_Mutation	NA	D466A	0.46
SKCM	chr5	143300574	Missense_Mutation	NA	P553L	0.24
SKCM	chr5	143400100	Missense_Mutation	NA	P247L	0.31
SKCM	chr5	143400152	Missense_Mutation	novel	G230R	0.24
SKCM	chr5	143400153	Silent	rs763734598	A229A	0.23
SKCM	chr5	143310145	Missense_Mutation	NA	P474S	0.18
SKCM	chr5	143282000	Frame_Shift_Ins	novel	*L741Ffs3**	0.51
SKCM	chr5	143400559	Frame_Shift_Del	novel	*E94Nfs7**	0.08
SKCM	chr5	143399801	Nonsense_Mutation	novel	Q347*	0.09
SKCM	chr5	143310103	Silent	NA	L488L	0.49
SKCM	chr5	143400528	Silent	novel	F104F	0.28
STAD	chr5	143281987	Missense_Mutation	novel	S746G	0.12
STAD	chr5	143399765	Missense_Mutation	rs370839677	V359I	0.09
STAD	chr5	143400465	Silent	NA	S125S	0.31
STAD	chr5	143400103	Nonsense_Mutation	novel	*K246Ifs2**	0.05
STAD	chr5	143400105	Nonsense_Mutation	novel	C245*	0.04
STAD	chr5	143310147	Missense_Mutation	NA	C473F	0.11
STAD	chr5	143314065	Nonsense_Mutation	NA	G430*	0.3
STAD	chr5	143282031	Missense_Mutation	NA	N731T	0.06
STAD	chr5	143282672	Missense_Mutation	novel	Y693D	0.32
STAD	chr5	143399710	Missense_Mutation	rs745857266	S377F	0.06
STAD	chr5	143281808	3'UTR	novel		0.12
STAD	chr5	143400733	Missense_Mutation	rs750532455	G36V	0.37
STAD	chr5	143310124	Missense_Mutation	novel	C481S	0.22
UCEC	chr5	143298710	Missense_Mutation	novel	S617T	0.07
UCEC	chr5	143281840	3'UTR	novel		0.28
UCEC	chr5	143400205	Missense_Mutation	NA	P212H	0.32
UCEC	chr5	143300527	Missense_Mutation	NA	R569W	0.31
UCEC	chr5	143400118	Missense_Mutation	NA	S241L	0.32
UCEC	chr5	143282032	Missense_Mutation	novel	N731H	0.16
UCEC	chr5	143399970	Silent	novel	G290G	0.34
UCEC	chr5	143279380	3'UTR	NA		0.3
UCEC	chr5	143281323	3'UTR	novel		0.34
UCEC	chr5	143400524	Nonsense_Mutation	NA	Q106*	0.37
UCEC	chr5	143279880	3'UTR	novel		0.24
UCEC	chr5	143399910	Silent	novel	N310N	0.26
UCEC	chr5	143282021	Silent	novel	N734N	0.38
UCEC	chr5	143399719	Missense_Mutation	rs771543340	N374S	0.36
UCEC	chr5	143279457	3'UTR	novel		0.36
UCEC	chr5	143300764	Splice_Site	novel	X490_splice	0.42
UCEC	chr5	143298747	Missense_Mutation	novel	A605T	0.48
UCEC	chr5	143400604	Missense_Mutation	novel	S79F	0.56
UCEC	chr5	143314054	Silent	novel	Y433Y	0.28
UCEC	chr5	143399975	Missense_Mutation	novel	P289S	0.2
UCEC	chr5	143279562	3'UTR	novel		0.26
UCEC	chr5	143282578	Missense_Mutation	NA	S724Y	0.14
UCEC	chr5	143400420	Missense_Mutation	rs756187323	K140N	0.17
UCEC	chr5	143281973	Silent	rs67300719	P750P	0.37
UCEC	chr5	143280249	3'UTR	novel		0.53
UCEC	chr5	143295497	Missense_Mutation	NA	E662D	0.12
UCEC	chr5	143279295	3'UTR	novel		0.19
UCEC	chr5	143310135	Missense_Mutation	rs104893913	R477H	0.19
UCEC	chr5	143281305	3'UTR	novel		0.33
UCEC	chr5	143279177	3'UTR	novel		0.44
UCEC	chr5	143400185	Missense_Mutation	NA	I219L	0.37
UCEC	chr5	143279583	3'UTR	rs10482711		0.53
UCEC	chr5	143280302	3'UTR	novel		0.12
UCEC	chr5	143300702	Missense_Mutation	novel	E510D	0.36
UCEC	chr5	143399684	Nonsense_Mutation	novel	R386*	0.45
UCEC	chr5	143280328	3'UTR	novel		0.13
UCEC	chr5	143279423	3'UTR	novel		0.25
UCEC	chr5	143281731	3'UTR	novel		0.08
UCEC	chr5	143281339	3'UTR	novel		0.19
UCEC	chr5	143295589	Nonsense_Mutation	NA	Q632*	0.2
UCEC	chr5	143281170	3'UTR	novel		0.36
UCEC	chr5	143281906	Silent	novel	L773L	0.3
UCEC	chr5	143279307	3'UTR	novel		0.39
UCEC	chr5	143280445	3'UTR	novel		0.33
UCEC	chr5	143282675	Missense_Mutation	novel	T692A	0.32
UCEC	chr5	143400118	Missense_Mutation	NA	S241L	0.35
UCEC	chr5	143279647	3'UTR	novel		0.55
UCEC	chr5	143281227	3'UTR	novel		0.54
UCEC	chr5	143281756	3'UTR	rs149554437		0.48
UCEC	chr5	143399881	Missense_Mutation	NA	S320Y	0.37
UCEC	chr5	143279264	3'UTR	novel		0.39
UCEC	chr5	143281662	3'UTR	novel		0.3
UCEC	chr5	143310160	Nonsense_Mutation	NA	R469*	0.47
UCEC	chr5	143399881	Missense_Mutation	NA	S320Y	0.58
UCEC	chr5	143400766	Missense_Mutation	novel	D25G	0.26
UCEC	chr5	143400535	Missense_Mutation	novel	L102P	0.15
UCEC	chr5	143400819	Silent	novel	L7L	0.16
UCEC	chr5	143279242	3'UTR	novel		0.31
UCEC	chr5	143281981	Frame_Shift_Ins	novel	*E748Hfs8**	0.08
UCEC	chr5	143298745	Silent	novel	A605A	0.19
UCEC	chr5	143300527	Missense_Mutation	NA	R569W	0.16
UCEC	chr5	143310160	Nonsense_Mutation	NA	R469*	0.29
UCEC	chr5	143399790	Missense_Mutation	novel	I350M	0.22
UCEC	chr5	143400665	Nonsense_Mutation	rs781064223	R59*	0.19
UCEC	chr5	143400387	Frame_Shift_Del	novel	*T152Qfs19**	0.37
UCEC	chr5	143400154	Missense_Mutation	NA	A229V	0.12
UCEC	chr5	143279342	3'UTR	novel		0.32
UCEC	chr5	143279142	3'UTR	novel		0.5
UCEC	chr5	143279269	3'UTR	novel		0.28
UCEC	chr5	143280452	3'UTR	novel		0.31
UCEC	chr5	143279577	3'UTR	novel		0.33
UCEC	chr5	143295471	Missense_Mutation	novel	L671P	0.36
UCEC	chr5	143300551	Missense_Mutation	novel	T561P	0.35
UCEC	chr5	143314106	Missense_Mutation	novel	P416Q	0.26
UCEC	chr5	143281480	3'UTR	novel		0.42
UCEC	chr5	143280377	3'UTR	novel		0.42
UCEC	chr5	143282026	Missense_Mutation	novel	L733I	0.41
UCEC	chr5	143400621	Silent	novel	A73A	0.53
UCEC	chr5	143280030	3'UTR	novel		0.67
UCEC	chr5	143280400	3'UTR	novel		0.43
UCEC	chr5	143281772	3'UTR	novel		0.13
UCEC	chr5	143399770	Missense_Mutation	NA	I357T	0.26
UCEC	chr5	143282578	Missense_Mutation	novel	S724F	0.36
UCEC	chr5	143279251	3'UTR	novel		0.15
UCEC	chr5	143279374	3'UTR	novel		0.26
UCEC	chr5	143400198	Silent	NA	R214R	0.21
UCEC	chr5	143281972	Missense_Mutation	NA	E751K	0.49
UCEC	chr5	143300661	Missense_Mutation	NA	T524M	0.1
UCEC	chr5	143400715	Missense_Mutation	NA	S42Y	0.39
UCEC	chr5	143400717	Silent	NA	V41V	0.3
UCEC	chr5	143279640	3'UTR	novel		0.5
UCEC	chr5	143282699	Nonsense_Mutation	NA	E684*	0.23
UCEC	chr5	143281976	Silent	novel	F749F	0.44
UCEC	chr5	143399881	Missense_Mutation	NA	S320Y	0.31
UCEC	chr5	143282002	Missense_Mutation	novel	L741V	0.14
UCEC	chr5	143298677	Missense_Mutation	novel	I628S	0.25
UCEC	chr5	143400260	Missense_Mutation	novel	L194V	0.28
UCEC	chr5	143282609	Missense_Mutation	rs771583164	R714W	0.23
UCEC	chr5	143400313	Missense_Mutation	novel	T176I	0.38
UCEC	chr5	143400753	Silent	novel	F29F	0.29
UCEC	chr5	143282586	Silent	novel	L721L	0.39
UCEC	chr5	143282600	Missense_Mutation	novel	Q717E	0.11
UCEC	chr5	143400622	Missense_Mutation	rs376527205	A73V	0.25
UCEC	chr5	143279388	3'UTR	novel		0.38
UCEC	chr5	143281804	3'UTR	novel		0.37
UCEC	chr5	143281261	3'UTR	novel		0.38
UCEC	chr5	143281379	3'UTR	novel		0.56
UVM	chr5	143400614	Missense_Mutation	novel	P76S	0.42

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
KIRP	AMP	0.1076	0.069756
KIRP	DEL	0.0382	0.11554
LAML	DEL	0.089	1.2971e-07
LUSC	DEL	0.6148	0.002071
MESO	DEL	0.1379	0.20184
PRAD	AMP	0.0285	0.16448
SKCM	DEL	0.3161	2.2081e-08
THCA	AMP	0.0361	0.075436
THCA	DEL	0	0.23456

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.00033	Kaplan-Meier Survival Analysis
STAD	0.0028	Kaplan-Meier Survival Analysis
ACC	0.0075	Kaplan-Meier Survival Analysis
SKCM	0.0001	Kaplan-Meier Survival Analysis
KIRP	0.013	Kaplan-Meier Survival Analysis
BLCA	0.038	Kaplan-Meier Survival Analysis
KICH	0.0018	Kaplan-Meier Survival Analysis
UCEC	0.00063	Kaplan-Meier Survival Analysis
GBM	0.0065	Kaplan-Meier Survival Analysis
LGG	0.019	Kaplan-Meier Survival Analysis
THCA	0.032	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathway

Phenotype

GWAS

PPI

Gene Ontology

Description

Ensembl ID: ENSG00000113580 (Gene tree)
Gene ID: 2908
Gene Symbol: NR3C1
Alias: GR|GRL
Full Name: nuclear receptor subfamily 3 group C member 1
Gene Type: protein_coding
Specie: Homo_sapiens
Strand: Minus strand
Length: 157,582 bases
Position: chr5:143,277,931-143,435,512
Accession: 7978
Summary: This gene encodes glucocorticoid receptor, which can function both as a transcription factor that binds to glucocorticoid response elements in the promoters of glucocorticoid responsive genes to activate their transcription, and as a regulator of other transcription factors. This receptor is typically found in the cytoplasm, but upon ligand binding, is transported into the nucleus. It is involved in inflammatory responses, cellular proliferation, and differentiation in target tissues. Mutations in this gene are associated with generalized glucocorticoid resistance. Alternative splicing of this gene results in transcript variants encoding either the same or different isoforms. Additional isoforms resulting from the use of alternate in-frame translation initiation sites have also been described, and shown to be functional, displaying diverse cytoplasm-to-nucleus trafficking patterns and distinct transcriptional activities (PMID:15866175). [provided by RefSeq, Feb 2011]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
2411295	Chymotrypsin treatment of glucocorticoid receptor attenuates RNA-dependent inhibition of DNA binding. Evidence for a distinct RNA-binding site.	Biochim Biophys Acta	1985 Aug 30	Tymoczko JL	-
29421306	Prenatal cold stress: Effect on maternal hippocampus and offspring behavior in rats.	Behav Brain Res	2018 Jul 2	Lian S	doi: 10.1016/j.bbr.2018.02.002
30655309	UPFront and center in RNA decay: UPF1 in nonsense-mediated mRNA decay and beyond.	RNA	2019 Apr	Kim YK	doi: 10.1261/rna.070136.118
21148795	The human glucocorticoid receptor as an RNA-binding protein: global analysis of glucocorticoid receptor-associated transcripts and identification of a target RNA motif.	J Immunol	2011 Jan 15	Ishmael FT	doi: 10.4049/jimmunol.1001794
3571287	Interaction of RNA with transformed glucocorticoid receptor. I. Isolation and purification of the RNA.	J Biol Chem	1987 May 15	Ali M	-
2461303	RNA binding to the untransformed glucocorticoid receptor. Sensitivity to substrate-specific ribonucleases and characterization of a ribonucleic acid associated with the purified receptor.	Eur J Biochem	1988 Nov 1	Sablonniere B	-
9353307	The glucocorticoid receptor is associated with the RNA-binding nuclear matrix protein hnRNP U.	J Biol Chem	1997 Nov 7	Eggert M	-
23748442	ZFP36L2 is required for self-renewal of early burst-forming unit erythroid progenitors.	Nature	2013 Jul 4	Zhang L	doi: 10.1038/nature12215
25775514	Glucocorticoid receptor interacts with PNRC2 in a ligand-dependent manner to recruit UPF1 for rapid mRNA degradation.	Proc Natl Acad Sci U S A	2015 Mar 31	Cho H	doi: 10.1073/pnas.1409612112
28984199	Roles of alternative splicing in modulating transcriptional regulation.	BMC Syst Biol	2017 Oct 3	Li J	doi: 10.1186/s12918-017-0465-6.
31234698	Autophagic death of neural stem cells mediates chronic stress-induced decline of adult hippocampal neurogenesis and cognitive deficits.	Autophagy	2019 Jun 24:1-19	Jung S	doi: 10.1080/15548627.2019.1630222
6176278	[Possible function of RNA-binding proteins of eukaryotes: blocking of RNA accessibility for DNA-interacting (regulatory) protein].	Biokhimiia	1982 Mar	Romanov GA	-
7507835	Functional analysis of glucocorticoid and insulin response sequences in the rat insulin-like growth factor-binding protein-1 promoter.	Endocrinology	1994 Feb	Goswami R	-
21704145	Pharmacological evaluation of insulin mimetic novel suppressors of PEPCK gene transcription from Paeoniae Rubra Radix.	J Ethnopharmacol	2011 Sep 1	Juan YC	doi: 10.1016/j.jep.2011.06.007
7556904	Efficient hormone-inducible protein function in Xenopus laevis.	Dev Biol	1995 Sep	Kolm PJ	-
6974862	[Effect of steroid hormones on DNA matrix activity and glucocorticoid-receptor interaction].	Probl Endokrinol (Mosk)	1981 May-Jun	Golikov PP	-
6304200	Effects of glucocorticoids on the beta-adrenergic adenylate cyclase system of pig skin.	J Invest Dermatol	1983 Jun	Iizuka H	-
4084586	Ribonucleic acid is a component of the oligomeric, transformed mouse AtT-20 cell glucocorticoid receptor.	Biochemistry	1985 Dec 3	Kovacic-Milivojevic B	-
3798121	The glucocorticoid receptor protein binds to transfer RNA.	Science	1987 Jan 23	Ali M	-
2478132	Isolation and characterization of a mouse L cell variant deficient in glucocorticoid receptors.	Biochem Biophys Res Commun	1989 Oct 16	Housley PR	-
2441143	Sodium molybdate converts the RNA-associated transformed, oligomeric form of the glucocorticoid receptor into the transformed, monomeric form.	J Steroid Biochem	1987 Jul	Kasayama S	-
2278831	The steroid-binding properties of recombinant glucocorticoid receptor: a putative role for heat shock protein hsp90.	J Steroid Biochem Mol Biol	1990 Nov 30	Ohara-Nemoto Y	-
2169394	Dexamethasone inhibits insulin biosynthesis by destabilizing insulin messenger ribonucleic acid in hamster insulinoma cells.	Endocrinology	1990 Oct	Philippe J	-
1944389	Aging alters hepatic expression of insulin receptor and c-jun mRNA in the mouse.	Mutat Res	1991 Jan	Mote PL	-
1572314	Evidence that rodent epididymal sperm contain the Mr approximately 94,000 glucocorticoid receptor but lack the Mr approximately 90,000 heat shock protein.	Endocrinology	1992 May	Kaufmann SH	-
8707409	Steroid-hormone receptors in cell lines and tumor biopsies of human lung cancer.	Int J Cancer	1996 Jul 29	Kaiser U	-
7651385	A domain of the even-skipped protein represses transcription by preventing TFIID binding to a promoter: repression by cooperative blocking.	Mol Cell Biol	1995 Sep	Austin RJ	-
12485917	Steroid receptors in various glial cell lines expression and functional studies.	Ann N Y Acad Sci	2002 Nov	Cadepond F	-
16087666	Regulation of the dynamics of hsp90 action on the glucocorticoid receptor by acetylation/deacetylation of the chaperone.	J Biol Chem	2005 Oct 7	Murphy PJ	-
15203078	Expression of human glucocorticoid receptor in lymphocytes of patients with autoimmune hepatitis.	Hepatol Res	2004 Jul	Rai T	-
17901074	Paradox of glucocorticoid-induced cytosolic phospholipase A2 group IVA messenger RNA expression involves glucocorticoid receptor binding to the promoter in human amnion fibroblasts.	Biol Reprod	2008 Jan	Guo C	-
21222652	Diet-induced epigenetic regulation in vivo of the intestinal fructose transporter Glut5 during development of rat small intestine.	Biochem J	2011 Apr 1	Suzuki T	doi: 10.1042/BJ20101987.
25203139	Inactivation of histone deacetylase 1 (HDAC1) but not HDAC2 is required for the glucocorticoid-dependent CCAAT/enhancer-binding protein α (C/EBPα) expression and preadipocyte differentiation.	Endocrinology	2014 Dec	Kuzmochka C	doi: 10.1210/en.2014-1565
31147715	The glucocorticoid receptor DNA-binding domain recognizes RNA hairpin structures with high affinity.	Nucleic Acids Res	2019 May 31	Parsonnet NV	doi: 10.1093/nar/gkz486

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000415690	NR3C1-205	3789	-	ENSP00000387672	742 (aa)	-	P04150
ENST00000508760	NR3C1-214	547	-	ENSP00000425313	145 (aa)	-	Q3MSN4
ENST00000503201	NR3C1-209	2594	XM_011537637	ENSP00000427672	777 (aa)	XP_011535939	P04150
ENST00000510170	NR3C1-215	585	-	ENSP00000424747	145 (aa)	-	Q3MSN4
ENST00000502892	NR3C1-208	498	-	ENSP00000420856	145 (aa)	-	Q3MSN4
ENST00000505058	NR3C1-213	491	-	-	- (aa)	-	-
ENST00000514699	NR3C1-216	623	-	ENSP00000426478	145 (aa)	-	Q3MSN4
ENST00000231509	NR3C1-201	3556	-	ENSP00000231509	778 (aa)	-	P04150
ENST00000504336	NR3C1-211	611	-	-	- (aa)	-	-
ENST00000424646	NR3C1-206	4591	-	ENSP00000405282	751 (aa)	-	P04150
ENST00000394466	NR3C1-204	3245	XM_005268419	ENSP00000377979	778 (aa)	XP_005268476	P04150
ENST00000502500	NR3C1-207	585	-	ENSP00000425374	144 (aa)	-	D6RDA9
ENST00000503701	NR3C1-210	602	-	-	- (aa)	-	-
ENST00000343796	NR3C1-202	7286	-	ENSP00000343205	777 (aa)	-	P04150
ENST00000504572	NR3C1-212	3389	XM_005268422	ENSP00000422518	778 (aa)	XP_005268479	P04150
ENST00000394464	NR3C1-203	6795	XM_017009397	ENSP00000377977	777 (aa)	XP_016864886	P04150

Gene Model

Click here to download 's gene model file

Pathway

Pathway ID	Pathway Name	Source
hsa04080	Neuroactive ligand-receptor interaction	KEGG

Phenotype

ensgID	Trait	pValue	Pubmed ID
ENSG00000113580	Behcet Syndrome	7.97921047101944E-05	20622878
ENSG00000113580	Body Height	6.8640000E-005	-
ENSG00000113580	Body Height	9.7370000E-005	-
ENSG00000113580	Body Height	1.0520000E-005	-
ENSG00000113580	Body Height	4.2640000E-005	-
ENSG00000113580	Waist Circumference	4.1120000E-005	-
ENSG00000113580	Waist Circumference	2.4500000E-005	-
ENSG00000113580	Waist Circumference	2.8160000E-005	-
ENSG00000113580	Waist Circumference	4.7470000E-005	-
ENSG00000113580	Blood Pressure	5.9990000E-005	-
ENSG00000113580	Blood Pressure	7.5880000E-005	-
ENSG00000113580	Asthma	8.9557770E-005	-
ENSG00000113580	Platelet Function Tests	1.6808300E-005	-
ENSG00000113580	Migraine Disorders	6E-6	23793025
ENSG00000113580	Linoleoyl-CoA Desaturase	6E-6	26584805
ENSG00000113580	gamma-Linolenic Acid	4E-6	26584805
ENSG00000113580	Sleep	6E-6	27126917
ENSG00000113580	Sleep	4E-7	27126917
ENSG00000113580	Linoleoyl-CoA Desaturase	6E-6	26584805
ENSG00000113580	gamma-Linolenic Acid	4E-6	26584805
ENSG00000113580	Sleep	8E-6	27126917
ENSG00000113580	Sleep Apnea, Obstructive	4E-7	26977737
ENSG00000113580	Risperidone	5E-7	20195266
ENSG00000113580	Alzheimer Disease	9E-7	26830138
ENSG00000113580	Age of Onset	9E-7	26830138

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000113580	rs6191	5	143278591	A	Night sleep phenotypes	27126917	[0.1-0.27] unit decrease	0.1867	EFO_0005271
ENSG00000113580	rs2963155	5	143376439	G	Breast cancer	29059683	[0.019-0.049] unit decrease	0.0339	EFO_0000305

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000113580's network

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000122	negative regulation of transcription by RNA polymerase II	12902338.	IMP	Process
GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	16728402.	IDA	Function
GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	-	ISA	Function
GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	19274049.	ISM	Function
GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	19274049.	NAS	Function
GO:0001047	core promoter binding	17081986.	IDA	Function
GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	16728402.23823477.	IDA	Function
GO:0003700	DNA-binding transcription factor activity	15769988.	IDA	Function
GO:0003723	RNA binding	-	IEA	Function
GO:0004879	nuclear receptor activity	17635946.	IDA	Function
GO:0004883	glucocorticoid receptor activity	-	IEA	Function
GO:0005496	steroid binding	15769988.	IDA	Function
GO:0005515	protein binding	9079630.10364267.11266503.12552091.12773562.12902338.15591535.15769988.15941832.16606617.16619302.16888650.17003263.17635946.17978169.19141540.20195357.21980503.22170608.23339905.24291004.24658140.24949977.27353360.	IPI	Function
GO:0005634	nucleus	9353307.15769988.17635946.22022502.23878391.	IDA	Component
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005737	cytoplasm	15769988.17635946.22022502.	IDA	Component
GO:0005759	mitochondrial matrix	10887960.	TAS	Component
GO:0005815	microtubule organizing center	-	IEA	Component
GO:0005819	spindle	-	IEA	Component
GO:0005829	cytosol	-	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0006325	chromatin organization	-	IEA	Process
GO:0006351	transcription, DNA-templated	17081986.	IDA	Process
GO:0006355	regulation of transcription, DNA-templated	19141540.	IDA	Process
GO:0006366	transcription by RNA polymerase II	8621628.	TAS	Process
GO:0006367	transcription initiation from RNA polymerase II promoter	-	TAS	Process
GO:0006915	apoptotic process	-	IEA	Process
GO:0007049	cell cycle	-	IEA	Process
GO:0007059	chromosome segregation	-	IEA	Process
GO:0007165	signal transduction	7769088.	TAS	Process
GO:0008270	zinc ion binding	-	IEA	Function
GO:0016607	nuclear speck	9353307.	IDA	Component
GO:0019901	protein kinase binding	20371704.	IPI	Function
GO:0032183	SUMO binding	17081986.	IPI	Function
GO:0032991	protein-containing complex	26593036.	IDA	Component
GO:0042921	glucocorticoid receptor signaling pathway	-	IEA	Process
GO:0043402	glucocorticoid mediated signaling pathway	-	IEA	Process
GO:0045944	positive regulation of transcription by RNA polymerase II	15769988.16728402.23823477.	IDA	Process
GO:0045944	positive regulation of transcription by RNA polymerase II	9353307.	IMP	Process
GO:0051301	cell division	-	IEA	Process
GO:0051879	Hsp90 protein binding	26593036.	IPI	Function
GO:0071383	cellular response to steroid hormone stimulus	15769988.17635946.	IDA	Process
GO:0071385	cellular response to glucocorticoid stimulus	9353307.	IDA	Process
GO:0071549	cellular response to dexamethasone stimulus	12902338.	IMP	Process
GO:0071560	cellular response to transforming growth factor beta stimulus	12902338.	IDA	Process
GO:1902895	positive regulation of pri-miRNA transcription by RNA polymerase II	27334923.	IDA	Process
GO:1990239	steroid hormone binding	17635946.	IDA	Function

EuRBPDB

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Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathway

Phenotype

GWAS

PPI

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.