EuRBPDB

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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
25847991Glucocorticoid receptor regulates accurate chromosome segregation and is associated with malignancy.Proc Natl Acad Sci U S A2015 Apr 28Matthews LCdoi: 10.1073/pnas.1411356112
21474440Glucocorticoid-independent repression of tumor necrosis factor (TNF) alpha-stimulated interleukin (IL)-6 expression by the glucocorticoid receptor: a potential mechanism for protection against an excessive inflammatory response.J Biol Chem2011 Jun 3Verhoog NJdoi: 10.1074/jbc.M110.193672
24622770Frequent promoter hypermethylation and expression reduction of the glucocorticoid receptor gene in breast tumors.Epigenetics2014 JunNesset KAdoi: 10.4161/epi.28484
27253665Testicular Receptor-4: Novel Regulator of Glucocorticoid Resistance.J Clin Endocrinol Metab2016 AugZhang Ddoi: 10.1210/jc.2016-1379
27060168Haploinsufficiency for NR3C1, the gene encoding the glucocorticoid receptor, in blastic plasmacytoid dendritic cell neoplasms.Blood2016 Jun 16Emadali Adoi: 10.1182/blood-2015-09-671040
29904891α-Viniferin activates autophagic apoptosis and cell death by reducing glucocorticoid receptor expression in castration-resistant prostate cancer cells.Med Oncol2018 Jun 15Cheng Kdoi: 10.1007/s12032-018-1163-y.
16806572Glucocorticoid receptor expression in advanced non-small cell lung cancer: clinicopathological correlation and in vitro effect of glucocorticoid on cell growth and chemosensitivity.Lung Cancer2006 SepLu YS-
24736075Glucocorticoid receptor status is a principal determinant of variability in the sensitivity of non-small-cell lung cancer cells to pemetrexed.J Thorac Oncol2014 AprPatki Mdoi: 10.1097/JTO.0000000000000111.
15590693Glucocorticoid receptor-induced MAPK phosphatase-1 (MPK-1) expression inhibits paclitaxel-associated MAPK activation and contributes to breast cancer cell survival.J Biol Chem2005 Feb 11Wu W-
17496926Glucocorticoid receptor overexpression exerts an antisurvival effect on human small cell lung cancer cells.Oncogene2007 Nov 1Sommer P-
21868756Activation of the glucocorticoid receptor is associated with poor prognosis in estrogen receptor-negative breast cancer.Cancer Res2011 Oct 15Pan Ddoi: 10.1158/0008-5472.CAN-11-0362
21984896Loss of glucocorticoid receptor expression by DNA methylation prevents glucocorticoid induced apoptosis in human small cell lung cancer cells.PLoS One2011Kay Pdoi: 10.1371/journal.pone.0024839
17512111Progesterone, glucocorticoid, but not estrogen receptor mRNA is altered in breast cancer stroma.Cancer Lett2007 Sep 18Smith RA-
19875955Estrogen receptor, progesterone receptor, and glucocorticoid receptor expression in normal breast tissue, breast in situ carcinoma, and invasive breast cancer.Appl Immunohistochem Mol Morphol2010 MayBuxant Fdoi: 10.1097/PAI.0b013e3181c10180.
18668364Glucocorticoid receptor expression in breast cancer associates with older patient age.Breast Cancer Res Treat2009 AugBelova Ldoi: 10.1007/s10549-008-0136-9
24615402Glucocorticoid receptor activity contributes to resistance to androgen-targeted therapy in prostate cancer.Horm Cancer2014 AprIsikbay Mdoi: 10.1007/s12672-014-0173-2
27179949Genetic variants in chromatin-remodeling pathway associated with lung cancer risk in a Chinese population.Gene2016 Aug 10Geng Ldoi: 10.1016/j.gene.2016.05.013
25043756Dihydrotestosterone enhances castration-resistant prostate cancer cell proliferation through STAT5 activation via glucocorticoid receptor pathway.Prostate2014 SepSong Cdoi: 10.1002/pros.22841
17952860Glucocorticoid receptor changes its cellular location with breast cancer development.Histol Histopathol2008 JanConde Idoi: 10.14670/HH-23.77.
21078539Glucocorticoid receptor signaling and prostate cancer.Cancer Lett2011 Mar 1Kassi Edoi: 10.1016/j.canlet.2010.10.020.
24629067The variant E233G of the RAD51D gene could be a low-penetrance allele in high-risk breast cancer families without BRCA1/2 mutations.Int J Cancer2004 Jul 20Rodr??guez-L??pez R-
27484907Epigenetic and Glucocorticoid Receptor-Mediated Regulation of Glutathione Peroxidase 3 in Lung Cancer Cells.Mol Cells2016 Aug 31An BCdoi: 10.14348/molcells.2016.0164

Differential Expression

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
ACCchr5143282616Silentrs775051931N711N0.33
BLCAchr5143400664Missense_MutationnovelR59Q0.13
BLCAchr5143400502Missense_Mutationrs764178904S113F0.41
BLCAchr5143300690SilentnovelN514N0.46
BLCAchr51432818533'UTRrs7616740330.24
BLCAchr51432818453'UTRnovel0.39
BLCAchr51434008405'UTRnovel0.48
BLCAchr5143400539Missense_MutationnovelD101H0.47
BLCAchr5143300760Missense_MutationNAR491Q0.25
BLCAchr5143300760Missense_MutationNAR491Q0.27
BLCAchr5143400279Missense_Mutationrs750705576D187E0.16
BLCAchr5143295502Missense_MutationnovelE661K0.18
BRCAchr5143399935Missense_MutationNAC302F0.08
BRCAchr5143300547Missense_Mutationrs761295829T562M0.29
BRCAchr5143400589Missense_MutationNAL84R0.37
BRCAchr5143310160Nonsense_MutationNAR469*0.2
BRCAchr5143281972Frame_Shift_DelnovelE751Rfs*30.06
CESCchr51432817213'UTRnovel0.2
CESCchr5143400661Missense_MutationnovelR60T0.36
CESCchr51432814133'UTRnovel0.53
CESCchr5143300558SilentnovelR558R0.36
CESCchr51432793673'UTRnovel0.36
CESCchr5143400683Missense_MutationNAQ53E0.27
CESCchr51432792943'UTRnovel0.4
CESCchr5143400266Missense_MutationNAD192H0.25
CESCchr51432797913'UTRnovel0.31
CESCchr51432798913'UTRnovel0.17
CESCchr5143400499Missense_Mutationrs756635644S114L0.1
CESCchr5143400592Missense_MutationNAS83L0.22
CHOLchr51432811883'UTRnovel0.28
CHOLchr51432814803'UTRnovel0.3
COADchr5143400814Missense_MutationNAP9H0.4
COADchr5143400154Missense_MutationNAA229V0.29
COADchr5143300660Silentrs138266608T524T0.47
COADchr51432818533'UTRrs7616740330.54
COADchr5143314036SilentNAG439G0.37
COADchr5143399809Missense_Mutationrs750359967Q344R0.24
COADchr5143399988SilentNAI284I0.23
COADchr5143298690Frame_Shift_InsnovelA624Cfs*30.25
COADchr51432818533'UTRrs7616740330.16
COADchr5143281976SilentnovelF749F0.54
COADchr5143310160Nonsense_MutationNAR469*0.39
COADchr5143281955SilentnovelI756I0.29
COADchr5143400175Missense_MutationNAN222T0.24
COADchr5143400339SilentNAQ167Q0.12
COADchr5143399874Frame_Shift_InsnovelV324Nfs*140.05
ESCAchr51432792633'UTRrs1156182480.24
ESCAchr51432798733'UTRnovel0.37
GBMchr5143310160Nonsense_MutationNAR469*0.18
GBMchr5143400569Missense_MutationnovelG91R0.1
GBMchr5143400720Missense_MutationnovelK40N0.06
GBMchr51434008455'UTRnovel0.1
HNSCchr51432817943'UTRnovel0.1
HNSCchr5143399917Missense_MutationnovelG308A0.08
HNSCchr51432818293'UTRnovel0.1
HNSCchr5143400602In_Frame_DelnovelP76_K80delinsQ0.08
HNSCchr5143295481Missense_MutationnovelT668P0.17
HNSCchr5143300587Missense_MutationnovelD549N0.16
KICHchr5143281999Missense_MutationnovelD742N0.28
KIRCchr5143400048SilentNAV264V0.14
KIRPchr5143295486Frame_Shift_DelnovelM666Efs*110.38
KIRPchr51432817593'UTRnovel0.08
KIRPchr51432817603'UTRnovel0.2
KIRPchr5143282578Missense_MutationnovelS724C0.41
LGGchr5143400085Missense_MutationNAD252G0.07
LGGchr5143282578Missense_MutationNAS724Y0.34
LGGchr5143400480SilentnovelK120K0.39
LIHCchr5143300489SilentNAI581I0.51
LIHCchr5143300680Nonsense_MutationnovelK518*0.16
LIHCchr51432793583'UTRnovel0.41
LUADchr5143400776Nonsense_MutationnovelE22*0.31
LUADchr5143400234SilentNAG202G0.19
LUADchr5143295518Missense_MutationnovelR655S0.25
LUADchr5143400592Missense_MutationNAS83L0.05
LUADchr5143282034Missense_MutationnovelE730G0.1
LUADchr5143400433Missense_MutationNAP136L0.2
LUADchr5143300709Nonsense_MutationnovelS508*0.1
LUADchr5143300566Missense_MutationnovelT556S0.1
LUADchr5143400621SilentnovelA73A0.76
LUADchr5143400287Missense_MutationnovelT185S0.08
LUADchr5143399935Missense_MutationNAC302F0.33
LUADchr5143282723Missense_MutationnovelP676S0.13
LUSCchr5143310159Missense_MutationNAR469Q0.28
LUSCchr5143300660SilentNAT524T0.55
LUSCchr5143400383Missense_Mutationrs766706619E153K0.47
LUSCchr5143310135Missense_Mutationrs104893913R477H0.33
LUSCchr5143300574Missense_MutationnovelP553R0.22
OVchr5143281972Missense_MutationNAE751K0.09
OVchr5143281908Missense_MutationNAL772P0.64
PAADchr5143295472Missense_MutationnovelL671I0.2
PAADchr5143314142Missense_MutationnovelS404Y0.19
READchr5143310130Nonsense_MutationNAR479*0.2
READchr5143399776Missense_MutationnovelP355Q0.08
READchr5143400689Missense_MutationNAA51T0.24
READchr5143400509Missense_MutationnovelS111C0.17
READchr5143281892SilentNAK777K0.27
READchr51432793273'UTRnovel0.5
READchr5143300625Missense_MutationnovelL536S0.06
READchr5143300704Nonsense_MutationnovelE510*0.4
READchr5143399988SilentNAI284I0.4
SARCchr51432814803'UTRnovel0.27
SKCMchr5143399869Missense_MutationNAV324E0.46
SKCMchr5143310168Missense_MutationNAD466A0.46
SKCMchr5143300574Missense_MutationNAP553L0.24
SKCMchr5143400100Missense_MutationNAP247L0.31
SKCMchr5143400152Missense_MutationnovelG230R0.24
SKCMchr5143400153Silentrs763734598A229A0.23
SKCMchr5143310145Missense_MutationNAP474S0.18
SKCMchr5143282000Frame_Shift_InsnovelL741Ffs*30.51
SKCMchr5143400559Frame_Shift_DelnovelE94Nfs*70.08
SKCMchr5143399801Nonsense_MutationnovelQ347*0.09
SKCMchr5143310103SilentNAL488L0.49
SKCMchr5143400528SilentnovelF104F0.28
STADchr5143281987Missense_MutationnovelS746G0.12
STADchr5143399765Missense_Mutationrs370839677V359I0.09
STADchr5143400465SilentNAS125S0.31
STADchr5143400103Nonsense_MutationnovelK246Ifs*20.05
STADchr5143400105Nonsense_MutationnovelC245*0.04
STADchr5143310147Missense_MutationNAC473F0.11
STADchr5143314065Nonsense_MutationNAG430*0.3
STADchr5143282031Missense_MutationNAN731T0.06
STADchr5143282672Missense_MutationnovelY693D0.32
STADchr5143399710Missense_Mutationrs745857266S377F0.06
STADchr51432818083'UTRnovel0.12
STADchr5143400733Missense_Mutationrs750532455G36V0.37
STADchr5143310124Missense_MutationnovelC481S0.22
UCECchr5143298710Missense_MutationnovelS617T0.07
UCECchr51432818403'UTRnovel0.28
UCECchr5143400205Missense_MutationNAP212H0.32
UCECchr5143300527Missense_MutationNAR569W0.31
UCECchr5143400118Missense_MutationNAS241L0.32
UCECchr5143282032Missense_MutationnovelN731H0.16
UCECchr5143399970SilentnovelG290G0.34
UCECchr51432793803'UTRNA0.3
UCECchr51432813233'UTRnovel0.34
UCECchr5143400524Nonsense_MutationNAQ106*0.37
UCECchr51432798803'UTRnovel0.24
UCECchr5143399910SilentnovelN310N0.26
UCECchr5143282021SilentnovelN734N0.38
UCECchr5143399719Missense_Mutationrs771543340N374S0.36
UCECchr51432794573'UTRnovel0.36
UCECchr5143300764Splice_SitenovelX490_splice0.42
UCECchr5143298747Missense_MutationnovelA605T0.48
UCECchr5143400604Missense_MutationnovelS79F0.56
UCECchr5143314054SilentnovelY433Y0.28
UCECchr5143399975Missense_MutationnovelP289S0.2
UCECchr51432795623'UTRnovel0.26
UCECchr5143282578Missense_MutationNAS724Y0.14
UCECchr5143400420Missense_Mutationrs756187323K140N0.17
UCECchr5143281973Silentrs67300719P750P0.37
UCECchr51432802493'UTRnovel0.53
UCECchr5143295497Missense_MutationNAE662D0.12
UCECchr51432792953'UTRnovel0.19
UCECchr5143310135Missense_Mutationrs104893913R477H0.19
UCECchr51432813053'UTRnovel0.33
UCECchr51432791773'UTRnovel0.44
UCECchr5143400185Missense_MutationNAI219L0.37
UCECchr51432795833'UTRrs104827110.53
UCECchr51432803023'UTRnovel0.12
UCECchr5143300702Missense_MutationnovelE510D0.36
UCECchr5143399684Nonsense_MutationnovelR386*0.45
UCECchr51432803283'UTRnovel0.13
UCECchr51432794233'UTRnovel0.25
UCECchr51432817313'UTRnovel0.08
UCECchr51432813393'UTRnovel0.19
UCECchr5143295589Nonsense_MutationNAQ632*0.2
UCECchr51432811703'UTRnovel0.36
UCECchr5143281906SilentnovelL773L0.3
UCECchr51432793073'UTRnovel0.39
UCECchr51432804453'UTRnovel0.33
UCECchr5143282675Missense_MutationnovelT692A0.32
UCECchr5143400118Missense_MutationNAS241L0.35
UCECchr51432796473'UTRnovel0.55
UCECchr51432812273'UTRnovel0.54
UCECchr51432817563'UTRrs1495544370.48
UCECchr5143399881Missense_MutationNAS320Y0.37
UCECchr51432792643'UTRnovel0.39
UCECchr51432816623'UTRnovel0.3
UCECchr5143310160Nonsense_MutationNAR469*0.47
UCECchr5143399881Missense_MutationNAS320Y0.58
UCECchr5143400766Missense_MutationnovelD25G0.26
UCECchr5143400535Missense_MutationnovelL102P0.15
UCECchr5143400819SilentnovelL7L0.16
UCECchr51432792423'UTRnovel0.31
UCECchr5143281981Frame_Shift_InsnovelE748Hfs*80.08
UCECchr5143298745SilentnovelA605A0.19
UCECchr5143300527Missense_MutationNAR569W0.16
UCECchr5143310160Nonsense_MutationNAR469*0.29
UCECchr5143399790Missense_MutationnovelI350M0.22
UCECchr5143400665Nonsense_Mutationrs781064223R59*0.19
UCECchr5143400387Frame_Shift_DelnovelT152Qfs*190.37
UCECchr5143400154Missense_MutationNAA229V0.12
UCECchr51432793423'UTRnovel0.32
UCECchr51432791423'UTRnovel0.5
UCECchr51432792693'UTRnovel0.28
UCECchr51432804523'UTRnovel0.31
UCECchr51432795773'UTRnovel0.33
UCECchr5143295471Missense_MutationnovelL671P0.36
UCECchr5143300551Missense_MutationnovelT561P0.35
UCECchr5143314106Missense_MutationnovelP416Q0.26
UCECchr51432814803'UTRnovel0.42
UCECchr51432803773'UTRnovel0.42
UCECchr5143282026Missense_MutationnovelL733I0.41
UCECchr5143400621SilentnovelA73A0.53
UCECchr51432800303'UTRnovel0.67
UCECchr51432804003'UTRnovel0.43
UCECchr51432817723'UTRnovel0.13
UCECchr5143399770Missense_MutationNAI357T0.26
UCECchr5143282578Missense_MutationnovelS724F0.36
UCECchr51432792513'UTRnovel0.15
UCECchr51432793743'UTRnovel0.26
UCECchr5143400198SilentNAR214R0.21
UCECchr5143281972Missense_MutationNAE751K0.49
UCECchr5143300661Missense_MutationNAT524M0.1
UCECchr5143400715Missense_MutationNAS42Y0.39
UCECchr5143400717SilentNAV41V0.3
UCECchr51432796403'UTRnovel0.5
UCECchr5143282699Nonsense_MutationNAE684*0.23
UCECchr5143281976SilentnovelF749F0.44
UCECchr5143399881Missense_MutationNAS320Y0.31
UCECchr5143282002Missense_MutationnovelL741V0.14
UCECchr5143298677Missense_MutationnovelI628S0.25
UCECchr5143400260Missense_MutationnovelL194V0.28
UCECchr5143282609Missense_Mutationrs771583164R714W0.23
UCECchr5143400313Missense_MutationnovelT176I0.38
UCECchr5143400753SilentnovelF29F0.29
UCECchr5143282586SilentnovelL721L0.39
UCECchr5143282600Missense_MutationnovelQ717E0.11
UCECchr5143400622Missense_Mutationrs376527205A73V0.25
UCECchr51432793883'UTRnovel0.38
UCECchr51432818043'UTRnovel0.37
UCECchr51432812613'UTRnovel0.38
UCECchr51432813793'UTRnovel0.56
UVMchr5143400614Missense_MutationnovelP76S0.42

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
KIRPAMP0.10760.069756
KIRPDEL0.03820.11554
LAMLDEL0.0891.2971e-07
LUSCDEL0.61480.002071
MESODEL0.13790.20184
PRADAMP0.02850.16448
SKCMDEL0.31612.2081e-08
THCAAMP0.03610.075436
THCADEL00.23456

Survival Analysis
CancerP-value Q-value
KIRC0.00033

Kaplan-Meier Survival Analysis

STAD0.0028

Kaplan-Meier Survival Analysis

ACC0.0075

Kaplan-Meier Survival Analysis

SKCM0.0001

Kaplan-Meier Survival Analysis

KIRP0.013

Kaplan-Meier Survival Analysis

BLCA0.038

Kaplan-Meier Survival Analysis

KICH0.0018

Kaplan-Meier Survival Analysis

UCEC0.00063

Kaplan-Meier Survival Analysis

GBM0.0065

Kaplan-Meier Survival Analysis

LGG0.019

Kaplan-Meier Survival Analysis

THCA0.032

Kaplan-Meier Survival Analysis

Drugs

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Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBPome
  • Literatures
  • Expression
  • Transcripts
  • Gene Model
  • Pathways
  • Phenotypes
  • GWAS
  • PPI
  • Gene Ontology
Description
Ensembl ID
ENSG00000113580 (Gene tree)
Gene ID
2908
Gene Symbol
NR3C1
Alias
GR|GRL
Full Name
nuclear receptor subfamily 3 group C member 1
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Minus strand
Length
157,582 bases
Position
chr5:143,277,931-143,435,512
Accession
7978
RBP type
non-canonical RBP
Summary
This gene encodes glucocorticoid receptor, which can function both as a transcription factor that binds to glucocorticoid response elements in the promoters of glucocorticoid responsive genes to activate their transcription, and as a regulator of other transcription factors. This receptor is typically found in the cytoplasm, but upon ligand binding, is transported into the nucleus. It is involved in inflammatory responses, cellular proliferation, and differentiation in target tissues. Mutations in this gene are associated with generalized glucocorticoid resistance. Alternative splicing of this gene results in transcript variants encoding either the same or different isoforms. Additional isoforms resulting from the use of alternate in-frame translation initiation sites have also been described, and shown to be functional, displaying diverse cytoplasm-to-nucleus trafficking patterns and distinct transcriptional activities (PMID:15866175). [provided by RefSeq, Feb 2011]
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
29431736Capturing the interactome of newly transcribed RNAPolyT-RICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
29431736Capturing the interactome of newly transcribed RNARICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & MCF10A2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
2411295Chymotrypsin treatment of glucocorticoid receptor attenuates RNA-dependent inhibition of DNA binding. Evidence for a distinct RNA-binding site.Biochim Biophys Acta1985 Aug 30Tymoczko JL-
29421306Prenatal cold stress: Effect on maternal hippocampus and offspring behavior in rats.Behav Brain Res2018 Jul 2Lian Sdoi: 10.1016/j.bbr.2018.02.002
30655309UPFront and center in RNA decay: UPF1 in nonsense-mediated mRNA decay and beyond.RNA2019 AprKim YKdoi: 10.1261/rna.070136.118
21148795The human glucocorticoid receptor as an RNA-binding protein: global analysis of glucocorticoid receptor-associated transcripts and identification of a target RNA motif.J Immunol2011 Jan 15Ishmael FTdoi: 10.4049/jimmunol.1001794
3571287Interaction of RNA with transformed glucocorticoid receptor. I. Isolation and purification of the RNA.J Biol Chem1987 May 15Ali M-
2461303RNA binding to the untransformed glucocorticoid receptor. Sensitivity to substrate-specific ribonucleases and characterization of a ribonucleic acid associated with the purified receptor.Eur J Biochem1988 Nov 1Sablonniere B-
9353307The glucocorticoid receptor is associated with the RNA-binding nuclear matrix protein hnRNP U.J Biol Chem1997 Nov 7Eggert M-
23748442ZFP36L2 is required for self-renewal of early burst-forming unit erythroid progenitors.Nature2013 Jul 4Zhang Ldoi: 10.1038/nature12215
25775514Glucocorticoid receptor interacts with PNRC2 in a ligand-dependent manner to recruit UPF1 for rapid mRNA degradation.Proc Natl Acad Sci U S A2015 Mar 31Cho Hdoi: 10.1073/pnas.1409612112
28984199Roles of alternative splicing in modulating transcriptional regulation.BMC Syst Biol2017 Oct 3Li Jdoi: 10.1186/s12918-017-0465-6.
31234698Autophagic death of neural stem cells mediates chronic stress-induced decline of adult hippocampal neurogenesis and cognitive deficits.Autophagy2019 Jun 24:1-19Jung Sdoi: 10.1080/15548627.2019.1630222
6176278[Possible function of RNA-binding proteins of eukaryotes: blocking of RNA accessibility for DNA-interacting (regulatory) protein].Biokhimiia1982 MarRomanov GA-
7507835Functional analysis of glucocorticoid and insulin response sequences in the rat insulin-like growth factor-binding protein-1 promoter.Endocrinology1994 FebGoswami R-
21704145Pharmacological evaluation of insulin mimetic novel suppressors of PEPCK gene transcription from Paeoniae Rubra Radix.J Ethnopharmacol2011 Sep 1Juan YCdoi: 10.1016/j.jep.2011.06.007
7556904Efficient hormone-inducible protein function in Xenopus laevis.Dev Biol1995 SepKolm PJ-
6974862[Effect of steroid hormones on DNA matrix activity and glucocorticoid-receptor interaction].Probl Endokrinol (Mosk)1981 May-JunGolikov PP-
6304200Effects of glucocorticoids on the beta-adrenergic adenylate cyclase system of pig skin.J Invest Dermatol1983 JunIizuka H-
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Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000415690NR3C1-2053789-ENSP00000387672742 (aa)-P04150
ENST00000508760NR3C1-214547-ENSP00000425313145 (aa)-Q3MSN4
ENST00000503201NR3C1-2092594XM_011537637ENSP00000427672777 (aa)XP_011535939P04150
ENST00000510170NR3C1-215585-ENSP00000424747145 (aa)-Q3MSN4
ENST00000502892NR3C1-208498-ENSP00000420856145 (aa)-Q3MSN4
ENST00000505058NR3C1-213491--- (aa)--
ENST00000514699NR3C1-216623-ENSP00000426478145 (aa)-Q3MSN4
ENST00000231509NR3C1-2013556-ENSP00000231509778 (aa)-P04150
ENST00000504336NR3C1-211611--- (aa)--
ENST00000424646NR3C1-2064591-ENSP00000405282751 (aa)-P04150
ENST00000394466NR3C1-2043245XM_005268419ENSP00000377979778 (aa)XP_005268476P04150
ENST00000502500NR3C1-207585-ENSP00000425374144 (aa)-D6RDA9
ENST00000503701NR3C1-210602--- (aa)--
ENST00000343796NR3C1-2027286-ENSP00000343205777 (aa)-P04150
ENST00000504572NR3C1-2123389XM_005268422ENSP00000422518778 (aa)XP_005268479P04150
ENST00000394464NR3C1-2036795XM_017009397ENSP00000377977777 (aa)XP_016864886P04150
Gene Model
Click here to download ENSG00000113580's gene model file
Pathways
Pathway IDPathway NameSource
hsa04080Neuroactive ligand-receptor interactionKEGG
Phenotypes
ensgIDTraitpValuePubmed ID
ENSG00000113580Behcet Syndrome7.97921047101944E-0520622878
ENSG00000113580Body Height6.8640000E-005-
ENSG00000113580Body Height9.7370000E-005-
ENSG00000113580Body Height1.0520000E-005-
ENSG00000113580Body Height4.2640000E-005-
ENSG00000113580Waist Circumference4.1120000E-005-
ENSG00000113580Waist Circumference2.4500000E-005-
ENSG00000113580Waist Circumference2.8160000E-005-
ENSG00000113580Waist Circumference4.7470000E-005-
ENSG00000113580Blood Pressure5.9990000E-005-
ENSG00000113580Blood Pressure7.5880000E-005-
ENSG00000113580Asthma8.9557770E-005-
ENSG00000113580Platelet Function Tests1.6808300E-005-
ENSG00000113580Migraine Disorders6E-623793025
ENSG00000113580Linoleoyl-CoA Desaturase6E-626584805
ENSG00000113580gamma-Linolenic Acid4E-626584805
ENSG00000113580Sleep6E-627126917
ENSG00000113580Sleep4E-727126917
ENSG00000113580Linoleoyl-CoA Desaturase6E-626584805
ENSG00000113580gamma-Linolenic Acid4E-626584805
ENSG00000113580Sleep8E-627126917
ENSG00000113580Sleep Apnea, Obstructive4E-726977737
ENSG00000113580Risperidone5E-720195266
ENSG00000113580Alzheimer Disease9E-726830138
ENSG00000113580Age of Onset9E-726830138
GWAS
ensgIDSNPChromosomePositionSNP-risk TraitPubmedID95% CIOr or BEAT EFO ID
ENSG00000113580rs61915143278591ANight sleep phenotypes27126917[0.1-0.27] unit decrease0.1867EFO_0005271
ENSG00000113580rs29631555143376439GBreast cancer29059683[0.019-0.049] unit decrease0.0339EFO_0000305
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000113580's network

* RBP PPI network refers to all genes directly bind to RBP
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0000122negative regulation of transcription by RNA polymerase II12902338.IMPProcess
GO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding16728402.IDAFunction
GO:0000981DNA-binding transcription factor activity, RNA polymerase II-specific-ISAFunction
GO:0000981DNA-binding transcription factor activity, RNA polymerase II-specific19274049.ISMFunction
GO:0000981DNA-binding transcription factor activity, RNA polymerase II-specific19274049.NASFunction
GO:0001047core promoter binding17081986.IDAFunction
GO:0001228DNA-binding transcription activator activity, RNA polymerase II-specific16728402.23823477.IDAFunction
GO:0003700DNA-binding transcription factor activity15769988.IDAFunction
GO:0003723RNA binding-IEAFunction
GO:0004879nuclear receptor activity17635946.IDAFunction
GO:0004883glucocorticoid receptor activity-IEAFunction
GO:0005496steroid binding15769988.IDAFunction
GO:0005515protein binding9079630.10364267.11266503.12552091.12773562.12902338.15591535.15769988.15941832.16606617.16619302.16888650.17003263.17635946.17978169.19141540.20195357.21980503.22170608.23339905.24291004.24658140.24949977.27353360.IPIFunction
GO:0005634nucleus9353307.15769988.17635946.22022502.23878391.IDAComponent
GO:0005654nucleoplasm-IDAComponent
GO:0005654nucleoplasm-TASComponent
GO:0005737cytoplasm15769988.17635946.22022502.IDAComponent
GO:0005759mitochondrial matrix10887960.TASComponent
GO:0005815microtubule organizing center-IEAComponent
GO:0005819spindle-IEAComponent
GO:0005829cytosol-IDAComponent
GO:0005829cytosol-TASComponent
GO:0006325chromatin organization-IEAProcess
GO:0006351transcription, DNA-templated17081986.IDAProcess
GO:0006355regulation of transcription, DNA-templated19141540.IDAProcess
GO:0006366transcription by RNA polymerase II8621628.TASProcess
GO:0006367transcription initiation from RNA polymerase II promoter-TASProcess
GO:0006915apoptotic process-IEAProcess
GO:0007049cell cycle-IEAProcess
GO:0007059chromosome segregation-IEAProcess
GO:0007165signal transduction7769088.TASProcess
GO:0008270zinc ion binding-IEAFunction
GO:0016607nuclear speck9353307.IDAComponent
GO:0019901protein kinase binding20371704.IPIFunction
GO:0032183SUMO binding17081986.IPIFunction
GO:0032991protein-containing complex26593036.IDAComponent
GO:0042921glucocorticoid receptor signaling pathway-IEAProcess
GO:0043402glucocorticoid mediated signaling pathway-IEAProcess
GO:0045944positive regulation of transcription by RNA polymerase II15769988.16728402.23823477.IDAProcess
GO:0045944positive regulation of transcription by RNA polymerase II9353307.IMPProcess
GO:0051301cell division-IEAProcess
GO:0051879Hsp90 protein binding26593036.IPIFunction
GO:0071383cellular response to steroid hormone stimulus15769988.17635946.IDAProcess
GO:0071385cellular response to glucocorticoid stimulus9353307.IDAProcess
GO:0071549cellular response to dexamethasone stimulus12902338.IMPProcess
GO:0071560cellular response to transforming growth factor beta stimulus12902338.IDAProcess
GO:1902895positive regulation of pri-miRNA transcription by RNA polymerase II27334923.IDAProcess
GO:1990239steroid hormone binding17635946.IDAFunction
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