EuRBPDB

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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
26694172Cytoplasmic Drosha Is Aberrant in Precancerous Lesions of Gastric Carcinoma and Its Loss Predicts Worse Outcome for Gastric Cancer Patients.Dig Dis Sci2016 AprZhang Hdoi: 10.1007/s10620-015-3986-0
26802027Chromosomal anomalies at 1q, 3, 16q, and mutations of SIX1 and DROSHA genes underlie Wilms tumor recurrences.Oncotarget2016 Feb 23Spreafico Fdoi: 10.18632/oncotarget.6950.
19092150Dicer, Drosha, and outcomes in patients with ovarian cancer.N Engl J Med2008 Dec 18Merritt WMdoi: 10.1056/NEJMoa0803785.
29236960MicroRNA-128-3p-mediated depletion of Drosha promotes lung cancer cell migration.Carcinogenesis2018 Feb 9Frixa Tdoi: 10.1093/carcin/bgx134.
23969986Proteomic identification of target proteins following Drosha knockdown in cervical cancer.Oncol Rep2013 NovZhou Jdoi: 10.3892/or.2013.2672
25656609EIF2C, Dicer, and Drosha are up-regulated along tumor progression and associated with poor prognosis in bladder carcinoma.Tumour Biol2015 JulZhang Zdoi: 10.1007/s13277-015-3158-z
21559780Major regulators of microRNAs biogenesis Dicer and Drosha are down-regulated in endometrial cancer.Tumour Biol2011 AugTorres Adoi: 10.1007/s13277-011-0179-0
18559093Integrative genomics analysis of chromosome 5p gain in cervical cancer reveals target over-expressed genes, including Drosha.Mol Cancer2008 Jun 17Scotto Ldoi: 10.1186/1476-4598-7-58.
261473043'-UTR Polymorphisms in the MiRNA Machinery Genes DROSHA, DICER1, RAN, and XPO5 Are Associated with Colorectal Cancer Risk in a Korean Population.PLoS One2015 Jul 6Cho SHdoi: 10.1371/journal.pone.0131125
24725360The expression of Dicer and Drosha in matched normal tissues, tumours and lymph node metastases in triple negative breast cancer.BMC Cancer2014 Apr 11Avery-Kiejda KAdoi: 10.1186/1471-2407-14-253.
23225145The microRNA maturation regulator Drosha is an independent predictor of outcome in breast cancer patients.Breast Cancer Res Treat2013 JanKhoshnaw SMdoi: 10.1007/s10549-012-2358-0
24312312Genetic variation in DROSHA 3'UTR regulated by hsa-miR-27b is associated with bladder cancer risk.PLoS One2013 Nov 28Yuan Ldoi: 10.1371/journal.pone.0081524
21898071Dysregulated expression of dicer and drosha in breast cancer.Pathol Oncol Res2012 AprYan Mdoi: 10.1007/s12253-011-9450-3
26156018High copy number variation of cancer-related microRNA genes and frequent amplification of DICER1 and DROSHA in lung cancer.Oncotarget2015 Sep 15Czubak K-
22496623Rare Drosha splice variants are deficient in microRNA processing but do not affect general microRNA expression in cancer cells.Neoplasia2012 MarGrund SE-
28155978Evaluation of polymorphisms in microRNA biosynthesis genes and risk of laryngeal cancer in the Polish population.Pol J Pathol2016Bruzgielewicz Adoi: 10.5114/pjp.2016.63781.
27380242Genetic variants in microRNA and microRNA biogenesis pathway genes and breast cancer risk among women of African ancestry.Hum Genet2016 OctQian Fdoi: 10.1007/s00439-016-1707-1

Differential Expression

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
ACCchr531526115Missense_MutationnovelR273I0.32
ACCchr531526869Nonsense_MutationnovelR22*0.21
BLCAchr531526742Nonsense_MutationnovelS64*0.43
BLCAchr531472148Missense_MutationNAI719T0.22
BLCAchr531472197Missense_MutationnovelL703V0.19
BLCAchr531526084SilentnovelR283R0.51
BLCAchr531526682Missense_MutationnovelP84R0.19
BLCAchr531515062Missense_MutationnovelE406Q0.44
BLCAchr531515117Missense_MutationNAI387M0.09
BLCAchr531526507SilentnovelF142F0.25
BLCAchr531521156Missense_MutationNAR305T0.08
BLCAchr531431641Missense_MutationNAG1027E0.38
BLCAchr531435830Missense_MutationnovelE993K0.31
BRCAchr531409063Missense_MutationNAL1283V0.22
BRCAchr531526090Silentrs770138873Y281Y0.25
BRCAchr531526435Nonsense_MutationnovelY166*0.11
BRCAchr531526437Missense_MutationnovelY166H0.11
BRCAchr531526700Missense_MutationNAF78C0.25
BRCAchr531526388Missense_MutationNAF182S0.19
BRCAchr531526823Missense_Mutationrs569160930Q37P0.26
BRCAchr531401506Missense_MutationNAE1351Q0.16
BRCAchr531495295Silentrs572424094T582T0.19
BRCAchr531401487Missense_MutationNAW1357L0.26
BRCAchr531422928Missense_MutationnovelT1093I0.16
BRCAchr531422929Missense_MutationnovelT1093S0.16
BRCAchr531515189SilentnovelA363A0.05
CESCchr531435811Missense_MutationnovelY999C0.27
CESCchr531526089Missense_Mutationrs748712078E282K0.24
CESCchr531409072Missense_MutationnovelD1280N0.2
CESCchr531448549Splice_RegionnovelS960S0.25
CESCchr531526205Frame_Shift_DelnovelR243Afs*250.17
CESCchr531409277Missense_MutationnovelM1241I0.48Ribonuclease_3
COADchr531401533Missense_MutationNAR1342W0.4
COADchr531511055Missense_Mutationrs754562615T471M0.37
COADchr531515176Nonsense_MutationNAE368*0.41
COADchr531421288Missense_MutationNAH1170R0.28Ribonuclease_3
COADchr531421344Missense_MutationNAD1151E0.2Ribonuclease_3
COADchr531472197Missense_MutationnovelL703I0.12
COADchr531449304Missense_MutationnovelH933P0.07
COADchr531511142Missense_MutationNAR442H0.06
COADchr531410760Missense_MutationNAA1218V0.14Ribonuclease_3
COADchr531449335Missense_Mutationrs766022493R923W0.24
COADchr531468022Missense_MutationNAQ761H0.63
COADchr531464304Nonsense_MutationnovelR836*0.07
COADchr531409281Missense_MutationnovelF1240S0.14Ribonuclease_3
COADchr531449351Silentrs542989519L917L0.06
COADchr531472064Missense_Mutationrs202101007T747M0.37
COADchr531511105SilentnovelS454S0.32
COADchr531526710Nonsense_Mutationrs762001670R75*0.34
COADchr531511157In_Frame_InsnovelV436_G437insAVV0.32
COADchr531526431Missense_MutationNAY168H0.25
COADchr531483597SilentnovelC676C0.17
COADchr531526463Frame_Shift_DelNAP157Lfs*690.31
COADchr531526905Missense_MutationNAM10V0.31
COADchr531504578Missense_MutationNAH549Y0.59
COADchr531521143Frame_Shift_DelNAE310Sfs*420.42
COADchr531435778Missense_MutationnovelA1010D0.07
COADchr531472064Missense_Mutationrs202101007T747M0.33
COADchr531493214Frame_Shift_InsNAL612Pfs*80.29
COADchr531410876SilentnovelS1179S0.23
COADchr531424465Missense_Mutationrs376727217R1075C0.29
COADchr531429497Missense_MutationNAG1065A0.16
COADchr531526726SilentnovelP69P0.3
COADchr531486508Nonsense_MutationnovelE633*0.38
ESCAchr531431583SilentnovelA1046A0.08
ESCAchr531508707Missense_MutationnovelV501L0.19
ESCAchr531424471Missense_MutationnovelD1073H0.09
ESCAchr5314012333'UTRnovel0.86
ESCAchr531424464Missense_MutationnovelR1075H0.14
GBMchr531526233Nonsense_MutationnovelR234*0.31
GBMchr531424462Missense_MutationnovelE1076Q0.29
GBMchr5314013313'UTRnovel0.38
GBMchr531467988Missense_MutationnovelV773I0.53
GBMchr531467973Missense_MutationNAR778C0.44
GBMchr531508758Missense_MutationNAE484K0.38
HNSCchr531409107Missense_MutationnovelC1268Y0.15
HNSCchr531515071Missense_MutationnovelE403K0.16
HNSCchr531511108SilentnovelG453G0.16
HNSCchr531422863In_Frame_DelnovelI1114_G1115delinsR0.05
HNSCchr531449407Missense_MutationnovelH899N0.29
KICHchr531521212Missense_MutationnovelE286D0.33
KIRCchr531429522Missense_MutationnovelL1057V0.34
KIRCchr531464247Missense_MutationnovelD855Y0.03
KIRPchr531526676Missense_MutationNAP86H0.48
KIRPchr531515132Missense_MutationNAK382N0.37
KIRPchr531526125Missense_MutationnovelD270Y0.19
KIRPchr531409134Missense_MutationnovelN1259S0.6
LGGchr531526196Missense_MutationNAS246F0.45
LGGchr531526403In_Frame_InsnovelF177delinsSL0.07
LIHCchr531472164Missense_MutationnovelV714L0.22
LIHCchr5315321195'Flanknovel0.33
LUADchr5314013873'UTRnovel0.24
LUADchr531526596Missense_MutationNAV113F0.32
LUADchr531526130Missense_MutationNAD268V0.15
LUADchr531515065Missense_MutationnovelE405K0.07
LUADchr531504552Splice_Regionnovel0.16
LUADchr531464293SilentnovelT839T0.07
LUADchr531495332Missense_MutationNAR570I0.65
LUADchr531448550Missense_MutationnovelS960L0.25
LUADchr531495301SilentNAP580P0.37
LUADchr531410836Nonsense_MutationNAE1193*0.13Ribonuclease_3
LUADchr531526268Missense_MutationnovelP222L0.08
LUADchr531448566Missense_MutationnovelD955Y0.27
LUADchr531401532Missense_MutationNAR1342L0.09
LUADchr531472197Missense_MutationnovelL703V0.04
LUADchr531483629Splice_SitenovelX666_splice0.38
LUADchr531526745Frame_Shift_DelnovelF63Sfs*450.15
LUADchr531429482Missense_MutationnovelN1070I0.36
LUADchr531464307Nonsense_MutationnovelR835*0.47
LUADchr531464308Missense_MutationnovelM834I0.47
LUADchr531448579Silentrs778275231S950S0.05
LUADchr531511067Missense_MutationNAE467V0.08
LUADchr531526079Missense_MutationNAR285I0.36
LUSCchr531511157Missense_MutationnovelG437A0.11
LUSCchr531472114Missense_MutationnovelW730C0.29
LUSCchr531483556Missense_MutationnovelP690L0.07
LUSCchr531449340Frame_Shift_InsnovelG921Vfs*230.25
LUSCchr531422896Missense_MutationnovelL1104I0.5
LUSCchr531429540Missense_MutationNAV1051I0.3
LUSCchr531466197Missense_MutationNAK817N0.33
LUSCchr531495302Missense_MutationnovelP580L0.17
LUSCchr531526482Missense_Mutationrs777764329M151V0.56
LUSCchr531515031Missense_MutationnovelT416S0.06
LUSCchr531526095Missense_MutationnovelS280C0.07
LUSCchr531508620Splice_SiteNAX529_splice0.34
LUSCchr531526537SilentNAV132V0.48
LUSCchr531515188Missense_MutationNAR364S0.4
LUSCchr531511110Missense_MutationNAG453W0.45
LUSCchr531526556Missense_MutationnovelC126F0.49
LUSCchr531448563Missense_MutationnovelD956Y0.47
LUSCchr531421379Splice_SitenovelX1140_splice0.31
LUSCchr531409087Nonsense_MutationNAE1275*0.17
LUSCchr531449360Missense_MutationnovelR914S0.61
LUSCchr531508658Missense_MutationnovelR517L0.26
LUSCchr531526209Nonsense_MutationnovelE242*0.12
LUSCchr531467997Missense_MutationNAP770S0.24
LUSCchr531515101Missense_Mutationrs151137891E393K0.08
MESOchr531526650Missense_Mutationrs758120846P95S0.32
OVchr531467992SilentnovelI771I0.09
OVchr531504593Missense_MutationnovelR544G0.52
OVchr531486515SilentnovelH630H0.06
OVchr531504592Missense_MutationNAR544H0.14
OVchr531401496Frame_Shift_InsnovelE1354Vfs*160.29
OVchr531449313Missense_MutationNAR930T0.2
OVchr531449316Missense_MutationNAD929V0.44
OVchr531422793Missense_MutationnovelL1138P0.05Ribonuclease_3
PAADchr531422938Missense_MutationnovelE1090K0.15
PAADchr531486522Missense_Mutationrs756470214T628M0.17
PAADchr531493230Missense_MutationnovelF607L0.17
PAADchr531421282Frame_Shift_DelnovelG1172Dfs*30.08Ribonuclease_3
PCPGchr531466272Frame_Shift_DelnovelK792Nfs*70.09
PRADchr531435786SilentnovelQ1007Q0.31
PRADchr531464274Missense_MutationnovelG846R0.45
READchr531464299SilentnovelE837E0.59
READchr531486521SilentNAT628T0.12
READchr531515037Missense_Mutationrs752147785R414Q0.41
READchr531422922Missense_MutationNAR1095Q0.45
SARCchr531526122Nonsense_Mutationrs753623166R271*0.15
SARCchr531508764Missense_MutationnovelE482K0.14
SARCchr531529043Missense_MutationnovelT6I0.14
SARCchr531424464Missense_MutationnovelR1075H0.14
SKCMchr531526892Missense_Mutationrs200373457P14L0.29
SKCMchr531526893Missense_MutationnovelP14S0.29
SKCMchr531421352SilentnovelL1149L0.06
SKCMchr531449355Missense_MutationnovelS916L0.08
SKCMchr531466238SilentNAL804L0.18
SKCMchr531526269Missense_MutationnovelP222A0.17
SKCMchr531526270SilentNAS221S0.18
SKCMchr531526506Missense_MutationNAP143S0.26
SKCMchr531526769Missense_MutationNAP55L0.91
SKCMchr531526537SilentNAV132V0.26
SKCMchr531451541SilentNAL892L0.2
SKCMchr531410765SilentNAT1216T0.41
SKCMchr531526295Missense_Mutationrs779587523P213L0.42
SKCMchr531526296Missense_MutationnovelP213S0.41
SKCMchr531515218Missense_Mutationrs369352228R354C0.26
SKCMchr531508771SilentnovelS479S0.5
SKCMchr531521163SilentNAL303L0.43
SKCMchr531466247Missense_Mutationrs376262500R801C0.43
SKCMchr531526507SilentnovelF142F0.42
SKCMchr531451605SilentNAI870I0.53
SKCMchr531472211Missense_MutationNAS698F0.27
SKCMchr531401525Silentrs200996611I1344I0.14
SKCMchr5314013113'UTRnovel0.24
SKCMchr531422836SilentNAL1124L0.25
SKCMchr531422845Missense_MutationNAV1121F0.93
SKCMchr531526473Missense_Mutationrs558382994P154S0.37
SKCMchr531526535Missense_MutationnovelP133L0.14
SKCMchr531526536Missense_MutationNAP133S0.13
STADchr531406913Missense_MutationNAR1296Q0.25
STADchr531526779Nonsense_MutationNAQ52*0.27
STADchr531515072SilentNAE402E0.25
STADchr531421343Missense_MutationnovelS1152A0.27Ribonuclease_3
STADchr531504592Missense_MutationNAR544H0.32
STADchr531526667Missense_Mutationrs200906186A89V0.39
STADchr531449320Missense_MutationNAG928R0.33
STADchr531508679Missense_MutationNAR510H0.28
STADchr531521134SilentNAK312K0.34
STADchr531526235Missense_MutationnovelH233L0.06
STADchr531526709Missense_Mutationrs546365755R75Q0.23
STADchr531526387SilentnovelF182F0.14
STADchr531449369SilentNAD911D0.23
STADchr531511112Missense_MutationnovelL452S0.29
STADchr531401520Missense_MutationNAR1346Q0.23
STADchr531401461Frame_Shift_InsnovelP1366Sfs*240.16
STADchr531526685Frame_Shift_DelNAP83Hfs*250.3
STADchr531508658Missense_MutationnovelR517Q0.32
THCAchr5314012883'UTRnovel0.27
THCAchr5315290835'UTRnovel0.33
UCECchr531410757Missense_MutationnovelD1219V0.15Ribonuclease_3
UCECchr5314012403'UTRnovel0.47
UCECchr531515484Missense_MutationNAS343Y0.36
UCECchr531521187Nonsense_Mutationrs751444046R295*0.31
UCECchr531401497Nonsense_MutationnovelE1354*0.05
UCECchr531493267Silentrs746967129Y594Y0.19
UCECchr531486495Missense_MutationNAP637L0.48
UCECchr5315290905'UTRnovel0.28
UCECchr531526843SilentnovelS30S0.32
UCECchr531421292Missense_MutationNAH1169N0.28Ribonuclease_3
UCECchr531464294Missense_MutationNAT839M0.42
UCECchr531515049Missense_MutationnovelP410L0.35
UCECchr531526566Missense_MutationnovelP123S0.42
UCECchr531526463Frame_Shift_DelNAP157Lfs*690.63
UCECchr531472086Missense_Mutationrs772310351M740V0.31
UCECchr531526470Missense_MutationnovelP155S0.58
UCECchr531515072SilentNAE402E0.33
UCECchr531422836SilentNAL1124L0.41
UCECchr531493267Silentrs746967129Y594Y0.29
UCECchr531526829Missense_MutationNAR35M0.31
UCECchr531511127Missense_MutationNAK447T0.24
UCECchr5314012753'UTRnovel0.18
UCECchr531526230Missense_MutationnovelD235N0.22
UCECchr5314013553'UTRnovel0.1
UCECchr531406916Missense_MutationnovelA1295V0.18
UCECchr531472197Missense_MutationnovelL703I0.28
UCECchr531521210Missense_MutationnovelR287L0.45
UCECchr531431614Missense_MutationnovelL1036P0.07
UCECchr531421281SilentnovelG1172G0.25
UCECchr531410781Missense_Mutationrs771452865A1211V0.34Ribonuclease_3
UCECchr531504592Missense_MutationNAR544H0.39
UCECchr531448603SilentnovelI942I0.11
UCECchr531409320Missense_MutationnovelA1227V0.32Ribonuclease_3
UCECchr531511086Missense_MutationnovelA461S0.63
UCECchr531526308Missense_MutationnovelP209T0.45
UCECchr531464328Frame_Shift_DelNAI828Yfs*70.36
UCECchr531511142Missense_MutationNAR442H0.47
UCECchr531431659Missense_MutationNAF1021C0.49
UCECchr531526340Missense_MutationnovelN198T0.09
UCECchr531421324Missense_MutationnovelA1158V0.34Ribonuclease_3
UCECchr531486519Missense_MutationnovelI629T0.31
UCECchr531515048SilentnovelP410P0.18
UCECchr531422855Missense_MutationnovelI1117M0.18
UCECchr531431662Missense_Mutationrs767861074R1020Q0.13
UCECchr531449335Missense_Mutationrs766022493R923W0.13
UCECchr531472078SilentnovelV742V0.2
UCECchr531484914Missense_MutationnovelD655Y0.19
UCECchr531508632Missense_MutationnovelD526N0.17
UCECchr531435792SilentnovelQ1005Q0.26
UCECchr531424463SilentnovelR1075R0.48
UCECchr531495357Missense_MutationnovelR562C0.38
UCECchr531515023Nonsense_MutationnovelE419*0.41
UCECchr531526666Silentrs375941240A89A0.39
UCECchr531526835Missense_MutationnovelS33Y0.4
UCECchr531515105SilentnovelE391E0.33
UCECchr531429481SilentnovelN1070N0.44
UCECchr531521143Frame_Shift_DelNAE310Sfs*420.45
UCECchr531515188Missense_Mutationrs756537138R364C0.31
UCECchr531521187Nonsense_Mutationrs751444046R295*0.15
UCECchr531486495Missense_MutationNAP637R0.21
UCECchr531504606Silentrs372996287S539S0.25
UCECchr531515508Missense_MutationnovelG335E0.12
UCECchr531448589Nonsense_MutationnovelN947delinsI*YAH0.07
UCECchr531410824Nonsense_MutationnovelQ1197*0.31Ribonuclease_3
UCECchr531448550Missense_MutationnovelS960L0.5
UCECchr531451623SilentnovelP864P0.28
UCECchr531472060Splice_Regionnovel0.12
UCECchr531521211Nonsense_Mutationrs749032311R287*0.3
UCECchr531511153Silentrs374026742T438T0.41
UCECchr531526261Silentrs765986893R224R0.23
UCECchr531435821Missense_MutationnovelL996I0.2
UCECchr531493214Frame_Shift_InsNAL612Pfs*80.27
UCECchr531526648Frame_Shift_DelNAC96Afs*120.41
UCECchr531526709Missense_Mutationrs546365755R75Q0.27
UCECchr5315290675'UTRnovel0.29
UCECchr531515484Missense_MutationNAS343Y0.22
UCECchr531424465Missense_Mutationrs376727217R1075C0.42
UCECchr531511153Silentrs374026742T438T0.56
UCECchr531493238Missense_MutationnovelF604C0.36
UCECchr531511142Missense_MutationNAR442H0.44
UCECchr531495302Missense_MutationnovelP580L0.32
UCECchr531405712Missense_MutationnovelA1320V0.41
UCECchr531410856Missense_MutationnovelT1186I0.3Ribonuclease_3
UCECchr531504592Missense_MutationNAR544H0.42
UCSchr531424464Missense_MutationnovelR1075H0.28
UCSchr531464258Missense_MutationNAG851V0.37
UVMchr531526385Frame_Shift_DelnovelN183Ifs*430.53

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
COADAMP0.16410.030224
TGCTDEL0.58670.11998
THCADEL0.0020.23456

Survival Analysis
CancerP-value Q-value
SARC0.034

Kaplan-Meier Survival Analysis

MESO0.018

Kaplan-Meier Survival Analysis

BLCA0.036

Kaplan-Meier Survival Analysis

READ0.01

Kaplan-Meier Survival Analysis

KICH0.013

Kaplan-Meier Survival Analysis

UCEC0.0035

Kaplan-Meier Survival Analysis

LIHC0.00024

Kaplan-Meier Survival Analysis

LGG0.00051

Kaplan-Meier Survival Analysis

CHOL0.037

Kaplan-Meier Survival Analysis

Drugs

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Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBDs
  • RBPome
  • PRI
  • Literatures
  • Expression
  • Transcripts
  • Gene Model
  • Pathways
  • Phenotypes
  • PPI
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000113360 (Gene tree)
Gene ID
29102
Gene Symbol
DROSHA
Alias
RNASE3L|Etohi2|HSA242976|RN3|RNASEN
Full Name
drosha ribonuclease III
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Minus strand
Length
131,703 bases
Position
chr5:31,400,494-31,532,196
Accession
17904
RBP type
canonical RBP
Summary
This gene encodes a ribonuclease (RNase) III double-stranded RNA-specific ribonuclease and subunit of the microprocessor protein complex, which catalyzes the initial processing step of microRNA (miRNA) synthesis. The encoded protein cleaves the stem loop structure from the primary microRNA (pri-miRNA) in the nucleus, yielding the precursor miRNA (pre-miRNA), which is then exported to the cytoplasm for further processing. In a human cell line lacking a functional copy of this gene, canonical miRNA synthesis is reduced. Somatic mutations in this gene have been observed in human patients with kidney cancer. [provided by RefSeq, Sep 2016]
RNA binding domains(RBDs)
Protein IDDomain Pfam IDE-value Domain number Total number
ENSP00000409335Ribonuclease_3PF00636.264.5e-4212
ENSP00000409335Ribonuclease_3PF00636.264.5e-4222
ENSP00000424161Ribonuclease_3PF00636.264.5e-4212
ENSP00000424161Ribonuclease_3PF00636.264.5e-4222
ENSP00000339845Ribonuclease_3PF00636.264.6e-4212
ENSP00000339845Ribonuclease_3PF00636.264.6e-4222
ENSP00000425979Ribonuclease_3PF00636.264.6e-4212
ENSP00000425979Ribonuclease_3PF00636.264.6e-4222
ENSP00000339845dsrmPF00035.264e-1411
ENSP00000425979dsrmPF00035.264e-1411
ENSP00000409335dsrmPF00035.264.1e-1411
ENSP00000424161dsrmPF00035.264.1e-1411
ENSP00000409335Ribonucleas_3_3PF14622.61.3e-4312
ENSP00000409335Ribonucleas_3_3PF14622.61.3e-4322
ENSP00000424161Ribonucleas_3_3PF14622.61.3e-4312
ENSP00000424161Ribonucleas_3_3PF14622.61.3e-4322
ENSP00000339845Ribonucleas_3_3PF14622.61.4e-4312
ENSP00000339845Ribonucleas_3_3PF14622.61.4e-4322
ENSP00000425979Ribonucleas_3_3PF14622.61.4e-4312
ENSP00000425979Ribonucleas_3_3PF14622.61.4e-4322
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
22681889The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts4SURIC & HEK2932012 MayBaltz AGDOI: 10.1016/j.molcel.2012.05.021
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & HEK2932019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
22658674Insights into RNA biology from an atlas of mammalian mRNA-binding proteinsRIC & Hela2012 May 31Castello ADOI: 10.1016/j.cell.2012.04.031
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & Hela2018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
Protein-RNA interaction(RNA-Binding Site)
Click here to download all RNA binding sites
Click here to download all RNA binding sites

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
17387036Regulatory mechanisms employed by cis-encoded antisense RNAs.Curr Opin Microbiol2007 AprBrantl S-
23776147Processing of virus-derived cytoplasmic primary-microRNAs.Wiley Interdiscip Rev RNA2013 Jul-AugShapiro JSdoi: 10.1002/wrna.1169
20226070Solution structure of the Drosha double-stranded RNA-binding domain.Silence2010 Jan 12Mueller GAdoi: 10.1186/1758-907X-1-2.
28792523Engineering double-stranded RNA binding activity into the Drosha double-stranded RNA binding domain results in a loss of microRNA processing function.PLoS One2017 Aug 8Kranick JCdoi: 10.1371/journal.pone.0182445
29109067The insertion in the double-stranded RNA binding domain of human Drosha is important for its function.Biochim Biophys Acta Gene Regul Mech2017 DecZhang Xdoi: 10.1016/j.bbagrm.2017.10.004
15099703Altered expression of CUG binding protein 1 mRNA in myotonic dystrophy 1: possible RNA-RNA interaction.Neurosci Res2004 MayWatanabe T-
17000903RNA aptamers binding the double-stranded RNA-binding domain.RNA2006 NovHallegger M-
16439209Structural insight into the mechanism of double-stranded RNA processing by ribonuclease III.Cell2006 Jan 27Gan J-
11809414Ribonuclease III: new sense from nuisance.Int J Biochem Cell Biol2002 FebConrad C-
10943893Substrate recognition by a eukaryotic RNase III: the double-stranded RNA-binding domain of Rnt1p selectively binds RNA containing a 5'-AGNN-3' tetraloop.RNA2000 AugNagel R-
15150409Structural basis for recognition of the AGNN tetraloop RNA fold by the double-stranded RNA-binding domain of Rnt1p RNase III.Proc Natl Acad Sci U S A2004 Jun 1Wu H-
18363798Mini-III, an unusual member of the RNase III family of enzymes, catalyses 23S ribosomal RNA maturation in B. subtilis.Mol Microbiol2008 JunRedko Ydoi: 10.1111/j.1365-2958.2008.06207.x
21632757Genomic and proteomic analysis of invertebrate iridovirus type 9.J Virol2011 AugWong CKdoi: 10.1128/JVI.00645-11
21133991Base substitutions at scissile bond sites are sufficient to alter RNA-binding and cleavage activity of RNase III.FEMS Microbiol Lett2011 FebKim Kdoi: 10.1111/j.1574-6968.2010.02169.x
23201338Intrinsic dynamics of an extended hydrophobic core in the S. cerevisiae RNase III dsRBD contributes to recognition of specific RNA binding sites.J Mol Biol2013 Feb 8Hartman Edoi: 10.1016/j.jmb.2012.11.025
25645556Stability of the osmoregulated promoter-derived proP mRNA is posttranscriptionally regulated by RNase III in Escherichia coli.J Bacteriol2015 AprLim Bdoi: 10.1128/JB.02460-14
24360955Drosha regulates gene expression independently of RNA cleavage function.Cell Rep2013 Dec 26Gromak Ndoi: 10.1016/j.celrep.2013.11.032
23851283In vivo mapping of RNA-RNA interactions in Staphylococcus aureus using the endoribonuclease III.Methods2013 Sep 15Lioliou Edoi: 10.1016/j.ymeth.2013.06.033
23637774miRNA biogenesis enzyme Drosha is required for vascular smooth muscle cell survival.PLoS One2013 Apr 18Fan Pdoi: 10.1371/journal.pone.0060888
23478018Sequestration of DROSHA and DGCR8 by expanded CGG RNA repeats alters microRNA processing in fragile X-associated tremor/ataxia syndrome.Cell Rep2013 Mar 28Sellier Cdoi: 10.1016/j.celrep.2013.02.004
28380355DGCR8 Mediates Repair of UV-Induced DNA Damage Independently of RNA Processing.Cell Rep2017 Apr 4Calses PCdoi: 10.1016/j.celrep.2017.03.021.
10051563Interaction of 5-lipoxygenase with cellular proteins.Proc Natl Acad Sci U S A1999 Mar 2Provost P-
9632264Genetic uncoupling of the dsRNA-binding and RNA cleavage activities of the Escherichia coli endoribonuclease RNase III--the effect of dsRNA binding on gene expression.Mol Microbiol1998 MayDasgupta S-
9241229Comparative sequence analysis of ribonucleases HII, III, II PH and D.Nucleic Acids Res1997 Aug 15Mian IS-
11738048Crystallographic and modeling studies of RNase III suggest a mechanism for double-stranded RNA cleavage.Structure2001 DecBlaszczyk J-
11265286Dissecting nucleases into their structural and functional domains. Mapping the RNA-binding surface of RNase III by NMR.Methods Mol Biol2001Ramos A-
15531877The Microprocessor complex mediates the genesis of microRNAs.Nature2004 Nov 11Gregory RI-
15531879Processing of primary microRNAs by the Microprocessor complex.Nature2004 Nov 11Denli AM-
15476399Mutational analysis of the nuclease domain of Escherichia coli ribonuclease III. Identification of conserved acidic residues that are important for catalytic function in vitro.Biochemistry2004 Oct 19Sun W-
15242644Single processing center models for human Dicer and bacterial RNase III.Cell2004 Jul 9Zhang H-
15192703A new alpha-helical extension promotes RNA binding by the dsRBD of Rnt1p RNAse III.EMBO J2004 Jul 7Leulliot N-
20015654Structure determinants for accurate processing of miR172a in Arabidopsis thaliana.Curr Biol2010 Jan 12Werner Sdoi: 10.1016/j.cub.2009.10.073.
19802599Processing of miRNA precursors.Methods Mol Biol2010Kurihara Ydoi: 10.1007/978-1-60327-005-2_15.
19759829Genomic analysis suggests that mRNA destabilization by the microprocessor is specialized for the auto-regulation of Dgcr8.PLoS One2009 Sep 11Shenoy Adoi: 10.1371/journal.pone.0006971.
19383765Post-transcriptional control of DGCR8 expression by the Microprocessor.RNA2009 JunTriboulet Rdoi: 10.1261/rna.1591709
19047376A Drosophila pasha mutant distinguishes the canonical microRNA and mirtron pathways.Mol Cell Biol2009 FebMartin Rdoi: 10.1128/MCB.01524-08
18957607The endonuclease activity of RNase III is required for the regulation of antibiotic production by Streptomyces coelicolor.Microbiology2008 NovGravenbeek MLdoi: 10.1099/mic.0.2008/022095-0.
18684997Frequency and fate of microRNA editing in human brain.Nucleic Acids Res2008 SepKawahara Ydoi: 10.1093/nar/gkn479
22961479Expression of microRNA machinery proteins in different types of chronic rhinosinusitis.Laryngoscope2012 DecZhang YNdoi: 10.1002/lary.23517
17666393Functional anatomy of the Drosophila microRNA-generating enzyme.J Biol Chem2007 Sep 28Ye X-
17369351Arabidopsis primary microRNA processing proteins HYL1 and DCL1 define a nuclear body distinct from the Cajal body.Proc Natl Acad Sci U S A2007 Mar 27Song L-
17259983DGCR8 is essential for microRNA biogenesis and silencing of embryonic stem cell self-renewal.Nat Genet2007 MarWang Y-
22796424Characterization of shrimp Drosha in virus infection.Fish Shellfish Immunol2012 SepHuang Tdoi: 10.1016/j.fsi.2012.06.014
22511778DiGeorge syndrome critical region 8 (DGCR8) protein-mediated microRNA biogenesis is essential for vascular smooth muscle cell development in mice.J Biol Chem2012 Jun 1Chen Zdoi: 10.1074/jbc.M112.351791
22308374Ferric, not ferrous, heme activates RNA-binding protein DGCR8 for primary microRNA processing.Proc Natl Acad Sci U S A2012 Feb 7Barr Idoi: 10.1073/pnas.1114514109
22222205Histone deacetylase 1 enhances microRNA processing via deacetylation of DGCR8.EMBO Rep2012 Feb 1Wada Tdoi: 10.1038/embor.2011.247.
21755470Stimulation of pri-miR-18a Processing by hnRNP A1.Adv Exp Med Biol2011Michlewski G-
21755472Hormonal Repression of miRNA Biosynthesis Through a Nuclear Steroid Hormone Receptor.Adv Exp Med Biol2011Fujiyama-Nakamura S-
21755473Autoregulatory mechanisms controlling the microprocessor.Adv Exp Med Biol2011Triboulet R-
21627027Stimulation of pri-miR-18a processing by hnRNP A1.Adv Exp Med Biol2010Michlewski G-
21627029Hormonal repression of miRNA biosynthesis through a nuclear steroid hormone receptor.Adv Exp Med Biol2010Fujiyama-Nakamura S-
21627030Autoregulatory mechanisms controlling the Microprocessor.Adv Exp Med Biol2010Triboulet R-
20554852Phosphorylation of the RNase III enzyme Drosha at Serine300 or Serine302 is required for its nuclear localization.Nucleic Acids Res2010 OctTang Xdoi: 10.1093/nar/gkq547
20506313Structure of the dimerization domain of DiGeorge critical region 8.Protein Sci2010 JulSenturia Rdoi: 10.1002/pro.414.
25176654The RNA-binding protein DDX1 promotes primary microRNA maturation and inhibits ovarian tumor progression.Cell Rep2014 Sep 11Han Cdoi: 10.1016/j.celrep.2014.07.058
24910438The DGCR8 RNA-binding heme domain recognizes primary microRNAs by clamping the hairpin.Cell Rep2014 Jun 26Quick-Cleveland Jdoi: 10.1016/j.celrep.2014.05.013
24449907Processing of microRNA primary transcripts requires heme in mammalian cells.Proc Natl Acad Sci U S A2014 Feb 4Weitz SHdoi: 10.1073/pnas.1309915111
24239349Phosphorylation of DGCR8 increases its intracellular stability and induces a progrowth miRNA profile.Cell Rep2013 Nov 27Herbert KMdoi: 10.1016/j.celrep.2013.10.017
24166303Primary microRNA processing assay reconstituted using recombinant Drosha and DGCR8.Methods Mol Biol2014Barr Idoi: 10.1007/978-1-62703-703-7_5.
23893406The core microprocessor component DiGeorge syndrome critical region 8 (DGCR8) is a nonspecific RNA-binding protein.J Biol Chem2013 Sep 13Roth BMdoi: 10.1074/jbc.M112.446880
23863141Cellular functions of the microprocessor.Biochem Soc Trans2013 AugMacias Sdoi: 10.1042/BST20130011.
23791529DNA-damage-induced nuclear export of precursor microRNAs is regulated by the ATM-AKT pathway.Cell Rep2013 Jun 27Wan Gdoi: 10.1016/j.celrep.2013.05.038
27546061Analysis of Heme Iron Coordination in DGCR8: The Heme-Binding Component of the Microprocessor Complex.Biochemistry2016 Sep 13Girvan HMdoi: 10.1021/acs.biochem.6b00204
26683315A heterotrimer model of the complete Microprocessor complex revealed by single-molecule subunit counting.RNA2016 FebHerbert KMdoi: 10.1261/rna.054684.115
26833131Deficiency in DGCR8-dependent canonical microRNAs causes infertility due to multiple abnormalities during uterine development in mice.Sci Rep2016 Feb 2Kim YSdoi: 10.1038/srep20242.
26126715The kinase ABL phosphorylates the microprocessor subunit DGCR8 to stimulate primary microRNA processing in response to DNA damage.Sci Signal2015 Jun 30Tu CCdoi: 10.1126/scisignal.aaa4468.
26091172Cobalt(III) Protoporphyrin Activates the DGCR8 Protein and Can Compensate microRNA Processing Deficiency.Chem Biol2015 Jun 18Barr Idoi: 10.1016/j.chembiol.2015.05.015.
25799998N6-methyladenosine marks primary microRNAs for processing.Nature2015 Mar 26Alarcon CRdoi: 10.1038/nature14281
27766492CO and NO bind to Fe(II) DiGeorge critical region 8 heme but do not restore primary microRNA processing activity.J Biol Inorg Chem2016 DecHines JP-
27634929Topology independent comparison of RNA 3D structures using the CLICK algorithm.Nucleic Acids Res2017 Jan 9Nguyen MNdoi: 10.1093/nar/gkw819
28846091NEAT1 scaffolds RNA-binding proteins and the Microprocessor to globally enhance pri-miRNA processing.Nat Struct Mol Biol2017 OctJiang Ldoi: 10.1038/nsmb.3455
29042235Splicing factors as regulators of miRNA biogenesis - links to human disease.Semin Cell Dev Biol2018 JulRatnadiwakara Mdoi: 10.1016/j.semcdb.2017.10.008
29171328Emerging roles of DROSHA beyond primary microRNA processing.RNA Biol2018 Feb 1Lee Ddoi: 10.1080/15476286.2017.1405210
29362439Deletion of DGCR8 in VSMCs of adult mice results in loss of vascular reactivity, reduced blood pressure and neointima formation.Sci Rep2018 Jan 23Zou Ydoi: 10.1038/s41598-018-19660-z.
29373746Distinct and redundant functions of three homologs of RNase III in the cyanobacterium Synechococcus sp. strain PCC 7002.Nucleic Acids Res2018 Feb 28Gordon GCdoi: 10.1093/nar/gky041.
29627294β-arrestin-biased agonism of β-adrenergic receptor regulates Dicer-mediated microRNA maturation to promote cardioprotective signaling.J Mol Cell Cardiol2018 MayTeoh JPdoi: 10.1016/j.yjmcc.2018.04.001
30554947Molecular Basis for the Single-Nucleotide Precision of Primary microRNA Processing.Mol Cell2019 Feb 7Kwon SCdoi: 10.1016/j.molcel.2018.11.005
10473621Ribonuclease III processing of coaxially stacked RNA helices.J Biol Chem1999 Sep 10Franch T-
12814522Functional interaction between RNase III and the Escherichia coli ribosome.BMC Mol Biol2003 Jun 18Allas U-
16428603The interaction between DCL1 and HYL1 is important for efficient and precise processing of pri-miRNA in plant microRNA biogenesis.RNA2006 FebKurihara Y-
16216575Intermediate states of ribonuclease III in complex with double-stranded RNA.Structure2005 OctGan J-
2977353Coliphage lambda to terminator lowers the stability of messenger RNA in Escherichia coli hosts.Gene1988 Dec 10Gross G-
2961741Bacteriophage lambda N gene leader RNA. RNA processing and translational initiation signals.J Biol Chem1987 Dec 25Steege DA-
12145215The global regulator RNase III modulates translation repression by the transcription elongation factor N.EMBO J2002 Aug 1Wilson HR-
11461923Temporal translational control by a metastable RNA structure.J Biol Chem2001 Sep 21Moller-Jensen J-
10648595The N-terminal domain that distinguishes yeast from bacterial RNase III contains a dimerization signal required for efficient double-stranded RNA cleavage.Mol Cell Biol2000 FebLamontagne B-
15574589The Drosha-DGCR8 complex in primary microRNA processing.Genes Dev2004 Dec 15Han J-
15016361Noncatalytic assembly of ribonuclease III with double-stranded RNA.Structure2004 MarBlaszczyk J-
20018860A protein-protein interaction map of trypanosome ~20S editosomes.J Biol Chem2010 Feb 19Schnaufer Adoi: 10.1074/jbc.M109.059378
24786770Drosha promotes splicing of a pre-microRNA-like alternative exon.PLoS Genet2014 May 1Havens MAdoi: 10.1371/journal.pgen.1004312
24274754RNase III: Genetics and function; structure and mechanism.Annu Rev Genet2013Court DLdoi: 10.1146/annurev-genet-110711-155618.
27560640Progress in micro RNA focused research in endocrinology.Endocr Regul2016 AprVoglova Kdoi: 10.1515/enr-2016-0012.
26786504Interaction of the tetracyclines with double-stranded RNAs of random base sequence: new perspectives on the target and mechanism of action.J Antibiot (Tokyo)2016 AugChukwudi CUdoi: 10.1038/ja.2015.145
29435107Discovery and functional implications of a miR-29b-1/miR-29a cluster polymorphism in acute myeloid leukemia.Oncotarget2017 Dec 12Ngankeu Adoi: 10.18632/oncotarget.23150
30210532Sinorhizobium meliloti RNase III: Catalytic Features and Impact on Symbiosis.Front Genet2018 Aug 28Saramago Mdoi: 10.3389/fgene.2018.00350
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000504361DROSHA-204583--- (aa)--
ENST00000509608DROSHA-209409--- (aa)--
ENST00000511778DROSHA-2131261--- (aa)--
ENST00000512885DROSHA-219437--- (aa)--
ENST00000510375DROSHA-211579--- (aa)--
ENST00000507174DROSHA-206572--- (aa)--
ENST00000509067DROSHA-208726--- (aa)--
ENST00000505601DROSHA-205552--- (aa)--
ENST00000510178DROSHA-210379--- (aa)--
ENST00000504133DROSHA-203617--- (aa)--
ENST00000512076DROSHA-2151124-ENSP00000422745375 (aa)-H7C5U6
ENST00000512302DROSHA-218585-ENSP00000428782195 (aa)-H0YB67
ENST00000511367DROSHA-2125305XM_005248291ENSP000004259791374 (aa)XP_005248348Q9NRR4
ENST00000442743DROSHA-2024991XM_017009402ENSP000004093351337 (aa)XP_016864891Q9NRR4
ENST00000513349DROSHA-2204681XM_005248294ENSP000004241611337 (aa)XP_005248351Q9NRR4
ENST00000511803DROSHA-214717--- (aa)--
ENST00000507438DROSHA-207860-ENSP00000430921201 (aa)-E5RHD1
ENST00000512124DROSHA-216555--- (aa)--
ENST00000344624DROSHA-2015102-ENSP000003398451374 (aa)-Q9NRR4
ENST00000512166DROSHA-217257--- (aa)--
ENST00000514927DROSHA-221567--- (aa)--
Gene Model
Click here to download ENSG00000113360's gene model file
Pathways
Pathway IDPathway NameSource
hsa03008Ribosome biogenesis in eukaryotesKEGG
hsa05205Proteoglycans in cancerKEGG
Phenotypes
ensgIDTraitpValuePubmed ID
ENSG00000113360Blood Vessels4.14943798233188E-617903301
ENSG00000113360Blood Vessels8.02227759964565E-717903301
ENSG00000113360Vital Capacity2.1580000E-005-
ENSG00000113360Platelet Function Tests1.3907700E-005-
ENSG00000113360Child Development Disorders, Pervasive2.3413100E-005-
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000113360's network

* RBP PPI network refers to all genes directly bind to RBP
Orthologs
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000113360DROSHA9996.364ENSAMEG00000006000DROSHA10096.218Ailuropoda_melanoleuca
ENSG00000113360DROSHA7191.167ENSACIG00000019308drosha9788.978Amphilophus_citrinellus
ENSG00000113360DROSHA8681.229ENSATEG00000021939drosha8781.072Anabas_testudineus
ENSG00000113360DROSHA9985.517ENSAPLG00000004372DROSHA10085.808Anas_platyrhynchos
ENSG00000113360DROSHA9982.433ENSACAG00000007970DROSHA10082.505Anolis_carolinensis
ENSG00000113360DROSHA10099.502ENSANAG00000020506DROSHA100100.000Aotus_nancymaae
ENSG00000113360DROSHA9675.602ENSACLG00000012227drosha8880.597Astatotilapia_calliptera
ENSG00000113360DROSHA9977.429ENSAMXG00000005582drosha8881.610Astyanax_mexicanus
ENSG00000113360DROSHA9997.820ENSBTAG00000017551DROSHA10097.820Bos_taurus
ENSG00000113360DROSHA6236.493WBGene00009163drsh-17636.623Caenorhabditis_elegans
ENSG00000113360DROSHA10099.701ENSCJAG00000018881DROSHA9899.701Callithrix_jacchus
ENSG00000113360DROSHA9998.952ENSCAFG00020017559DROSHA10098.952Canis_lupus_dingo
ENSG00000113360DROSHA9997.681ENSCHIG00000022226DROSHA10097.681Capra_hircus
ENSG00000113360DROSHA9698.120ENSCPOG00000015051DROSHA10088.937Cavia_porcellus
ENSG00000113360DROSHA10099.626ENSCCAG00000027283DROSHA100100.000Cebus_capucinus
ENSG00000113360DROSHA10099.709ENSCATG00000016833DROSHA100100.000Cercocebus_atys
ENSG00000113360DROSHA9998.573ENSCLAG00000013048DROSHA10098.573Chinchilla_lanigera
ENSG00000113360DROSHA10099.776ENSCSAG00000017202DROSHA9799.776Chlorocebus_sabaeus
ENSG00000113360DROSHA9793.299ENSCHOG00000011786DROSHA7892.574Choloepus_hoffmanni
ENSG00000113360DROSHA9989.304ENSCPBG00000000467DROSHA10089.379Chrysemys_picta_bellii
ENSG00000113360DROSHA6258.852ENSCSAVG00000010638-9958.852Ciona_savignyi
ENSG00000113360DROSHA10099.252ENSCANG00000035071DROSHA100100.000Colobus_angolensis_palliatus
ENSG00000113360DROSHA9996.795ENSCGRG00001008885Drosha10096.795Cricetulus_griseus_chok1gshd
ENSG00000113360DROSHA9996.795ENSCGRG00000006944Drosha10096.795Cricetulus_griseus_crigri
ENSG00000113360DROSHA9873.859ENSCSEG00000001452drosha8880.268Cynoglossus_semilaevis
ENSG00000113360DROSHA8383.141ENSCVAG00000004619drosha8881.918Cyprinodon_variegatus
ENSG00000113360DROSHA8284.054ENSDARG00000055563drosha8983.176Danio_rerio
ENSG00000113360DROSHA9992.758ENSDNOG00000001537DROSHA9992.758Dasypus_novemcinctus
ENSG00000113360DROSHA9992.679ENSDORG00000005624Drosha9992.507Dipodomys_ordii
ENSG00000113360DROSHA9346.262FBgn0026722drosha8548.293Drosophila_melanogaster
ENSG00000113360DROSHA8997.753ENSETEG00000007814DROSHA8997.753Echinops_telfairi
ENSG00000113360DROSHA5182.474ENSEBUG00000005974-9982.474Eptatretus_burgeri
ENSG00000113360DROSHA10099.028ENSEASG00005007149DROSHA10099.028Equus_asinus_asinus
ENSG00000113360DROSHA10099.028ENSECAG00000013578DROSHA9799.028Equus_caballus
ENSG00000113360DROSHA7990.278ENSEEUG00000006351DROSHA7990.269Erinaceus_europaeus
ENSG00000113360DROSHA9570.802ENSELUG00000015039drosha8276.455Esox_lucius
ENSG00000113360DROSHA10099.102ENSFCAG00000000360DROSHA10099.102Felis_catus
ENSG00000113360DROSHA9885.682ENSFALG00000012843DROSHA10085.588Ficedula_albicollis
ENSG00000113360DROSHA10098.358ENSFDAG00000018414DROSHA10098.358Fukomys_damarensis
ENSG00000113360DROSHA8764.120ENSFHEG00000003840drosha8269.275Fundulus_heteroclitus
ENSG00000113360DROSHA9988.024ENSGALG00000012916DROSHA10088.024Gallus_gallus
ENSG00000113360DROSHA8384.103ENSGAFG00000016853drosha8882.378Gambusia_affinis
ENSG00000113360DROSHA9989.230ENSGAGG00000005621DROSHA10089.230Gopherus_agassizii
ENSG00000113360DROSHA100100.000ENSGGOG00000011006DROSHA100100.000Gorilla_gorilla
ENSG00000113360DROSHA9471.991ENSHBUG00000015907drosha8776.978Haplochromis_burtoni
ENSG00000113360DROSHA10098.134ENSHGLG00000018873DROSHA9998.134Heterocephalus_glaber_female
ENSG00000113360DROSHA10098.134ENSHGLG00100015793DROSHA9898.134Heterocephalus_glaber_male
ENSG00000113360DROSHA8581.795ENSHCOG00000008454drosha9980.017Hippocampus_comes
ENSG00000113360DROSHA8482.379ENSIPUG00000021202drosha9079.209Ictalurus_punctatus
ENSG00000113360DROSHA7796.545ENSSTOG00000016323DROSHA100100.000Ictidomys_tridecemlineatus
ENSG00000113360DROSHA9997.293ENSJJAG00000019758Drosha10097.232Jaculus_jaculus
ENSG00000113360DROSHA9089.897ENSLBEG00000006606drosha10077.449Labrus_bergylta
ENSG00000113360DROSHA9981.981ENSLACG00000005937DROSHA8785.980Latimeria_chalumnae
ENSG00000113360DROSHA9978.009ENSLOCG00000012852drosha8882.024Lepisosteus_oculatus
ENSG00000113360DROSHA9996.934ENSLAFG00000013831DROSHA10096.934Loxodonta_africana
ENSG00000113360DROSHA10099.709ENSMFAG00000003055DROSHA10099.709Macaca_fascicularis
ENSG00000113360DROSHA10099.701ENSMMUG00000012193DROSHA10099.701Macaca_mulatta
ENSG00000113360DROSHA10099.551ENSMNEG00000037529DROSHA10099.491Macaca_nemestrina
ENSG00000113360DROSHA10099.502ENSMLEG00000024167DROSHA10094.691Mandrillus_leucophaeus
ENSG00000113360DROSHA8682.079ENSMAMG00000012613drosha9589.897Mastacembelus_armatus
ENSG00000113360DROSHA9675.602ENSMZEG00005019487drosha8880.597Maylandia_zebra
ENSG00000113360DROSHA9987.874ENSMGAG00000005087DROSHA10087.874Meleagris_gallopavo
ENSG00000113360DROSHA9996.504ENSMAUG00000002863Drosha10096.504Mesocricetus_auratus
ENSG00000113360DROSHA10098.010ENSMICG00000002241DROSHA10098.182Microcebus_murinus
ENSG00000113360DROSHA9996.413ENSMOCG00000015044Drosha10096.413Microtus_ochrogaster
ENSG00000113360DROSHA7286.804ENSMMOG00000004016drosha9785.271Mola_mola
ENSG00000113360DROSHA9986.902ENSMODG00000004807DROSHA9987.270Monodelphis_domestica
ENSG00000113360DROSHA9975.238ENSMALG00000010542drosha8881.757Monopterus_albus
ENSG00000113360DROSHA9995.633MGP_CAROLIEiJ_G0019687Drosha10095.633Mus_caroli
ENSG00000113360DROSHA9995.633ENSMUSG00000022191Drosha10095.633Mus_musculus
ENSG00000113360DROSHA9995.779MGP_PahariEiJ_G0016063Drosha10095.779Mus_pahari
ENSG00000113360DROSHA9995.124MGP_SPRETEiJ_G0020580Drosha10095.124Mus_spretus
ENSG00000113360DROSHA10098.617ENSMPUG00000015237DROSHA10098.617Mustela_putorius_furo
ENSG00000113360DROSHA10095.522ENSMLUG00000002581DROSHA10094.993Myotis_lucifugus
ENSG00000113360DROSHA9988.784ENSNGAG00000017329Drosha10091.260Nannospalax_galili
ENSG00000113360DROSHA7173.520ENSNBRG00000001870drosha9672.515Neolamprologus_brichardi
ENSG00000113360DROSHA10095.997ENSNLEG00000013963DROSHA100100.000Nomascus_leucogenys
ENSG00000113360DROSHA8079.134ENSMEUG00000002029DROSHA8279.134Notamacropus_eugenii
ENSG00000113360DROSHA9198.276ENSOPRG00000010845DROSHA9198.276Ochotona_princeps
ENSG00000113360DROSHA9998.038ENSODEG00000001911DROSHA10098.038Octodon_degus
ENSG00000113360DROSHA9874.909ENSONIG00000006578drosha8880.130Oreochromis_niloticus
ENSG00000113360DROSHA5880.488ENSOANG00000015744-10080.488Ornithorhynchus_anatinus
ENSG00000113360DROSHA10096.936ENSOCUG00000000367DROSHA9896.936Oryctolagus_cuniculus
ENSG00000113360DROSHA9974.537ENSORLG00000013592drosha8979.382Oryzias_latipes
ENSG00000113360DROSHA7387.935ENSORLG00020002854drosha9588.866Oryzias_latipes_hni
ENSG00000113360DROSHA7388.957ENSORLG00015003156drosha9589.897Oryzias_latipes_hsok
ENSG00000113360DROSHA8680.324ENSOMEG00000001062drosha8980.368Oryzias_melastigma
ENSG00000113360DROSHA9094.643ENSOGAG00000005424DROSHA10094.643Otolemur_garnettii
ENSG00000113360DROSHA99100.000ENSPPAG00000037526DROSHA100100.000Pan_paniscus
ENSG00000113360DROSHA10099.102ENSPPRG00000002687DROSHA10099.102Panthera_pardus
ENSG00000113360DROSHA10099.102ENSPTIG00000017523DROSHA10099.102Panthera_tigris_altaica
ENSG00000113360DROSHA100100.000ENSPTRG00000016762DROSHA100100.000Pan_troglodytes
ENSG00000113360DROSHA10099.776ENSPANG00000003027DROSHA10098.186Papio_anubis
ENSG00000113360DROSHA9978.167ENSPKIG00000011514drosha8982.773Paramormyrops_kingsleyae
ENSG00000113360DROSHA9995.924ENSPEMG00000000607Drosha10095.924Peromyscus_maniculatus_bairdii
ENSG00000113360DROSHA9988.533ENSPCIG00000006010DROSHA9988.608Phascolarctos_cinereus
ENSG00000113360DROSHA8383.791ENSPREG00000022302drosha8982.293Poecilia_reticulata
ENSG00000113360DROSHA10099.854ENSPPYG00000015370DROSHA10099.854Pongo_abelii
ENSG00000113360DROSHA9992.000ENSPCAG00000007190DROSHA10082.884Procavia_capensis
ENSG00000113360DROSHA10099.005ENSPCOG00000028511DROSHA10098.182Propithecus_coquereli
ENSG00000113360DROSHA9997.500ENSPVAG00000013167DROSHA10094.610Pteropus_vampyrus
ENSG00000113360DROSHA9675.452ENSPNYG00000000398drosha9887.251Pundamilia_nyererei
ENSG00000113360DROSHA8092.340ENSPNAG00000011876drosha8687.679Pygocentrus_nattereri
ENSG00000113360DROSHA9996.288ENSRNOG00000013451Drosha10096.288Rattus_norvegicus
ENSG00000113360DROSHA10099.005ENSRBIG00000032786DROSHA100100.000Rhinopithecus_bieti
ENSG00000113360DROSHA10099.782ENSRROG00000028199DROSHA10099.782Rhinopithecus_roxellana
ENSG00000113360DROSHA10099.402ENSSBOG00000024008DROSHA100100.000Saimiri_boliviensis_boliviensis
ENSG00000113360DROSHA9986.829ENSSHAG00000015198DROSHA9496.315Sarcophilus_harrisii
ENSG00000113360DROSHA9975.112ENSSFOG00015009776drosha9282.519Scleropages_formosus
ENSG00000113360DROSHA9874.359ENSSMAG00000008069drosha8879.785Scophthalmus_maximus
ENSG00000113360DROSHA8681.435ENSSDUG00000010944drosha9591.237Seriola_dumerili
ENSG00000113360DROSHA8681.572ENSSLDG00000025271drosha9591.134Seriola_lalandi_dorsalis
ENSG00000113360DROSHA7274.864ENSSARG00000004436-7375.573Sorex_araneus
ENSG00000113360DROSHA9983.619ENSSPUG00000006902DROSHA10083.619Sphenodon_punctatus
ENSG00000113360DROSHA9998.428ENSSSCG00000016809DROSHA10098.599Sus_scrofa
ENSG00000113360DROSHA9885.242ENSTGUG00000001955DROSHA10085.080Taeniopygia_guttata
ENSG00000113360DROSHA9373.529ENSTRUG00000017778drosha8579.433Takifugu_rubripes
ENSG00000113360DROSHA10073.169ENSTNIG00000008688drosha9590.349Tetraodon_nigroviridis
ENSG00000113360DROSHA9395.161ENSTBEG00000000537DROSHA10087.895Tupaia_belangeri
ENSG00000113360DROSHA9997.305ENSTTRG00000004210DROSHA10097.305Tursiops_truncatus
ENSG00000113360DROSHA10099.028ENSUAMG00000025257DROSHA10099.028Ursus_americanus
ENSG00000113360DROSHA9994.654ENSUMAG00000014097DROSHA10099.066Ursus_maritimus
ENSG00000113360DROSHA8093.038ENSVPAG00000011260DROSHA10093.038Vicugna_pacos
ENSG00000113360DROSHA10099.177ENSVVUG00000022212DROSHA10099.177Vulpes_vulpes
ENSG00000113360DROSHA9579.377ENSXETG00000016701drosha8880.017Xenopus_tropicalis
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0001530lipopolysaccharide binding20180804.IDAFunction
GO:0003723RNA binding22658674.22681889.HDAFunction
GO:0003725double-stranded RNA binding21873635.IBAFunction
GO:0004525ribonuclease III activity21873635.IBAFunction
GO:0004525ribonuclease III activity14508493.15574589.IDAFunction
GO:0005515protein binding15574589.18548003.19626115.22222205.22796965.23232809.23995758.24219989.24581491.26496610.IPIFunction
GO:0005634nucleus21873635.IBAComponent
GO:0005654nucleoplasm-TASComponent
GO:0005730nucleolus-IEAComponent
GO:0006396RNA processing21873635.IBAProcess
GO:0010586miRNA metabolic process-TASProcess
GO:0010628positive regulation of gene expression-IEAProcess
GO:0014069postsynaptic density-IEAComponent
GO:0016075rRNA catabolic process-IEAProcess
GO:0017151DEAD/H-box RNA helicase binding18548003.IPIFunction
GO:0030422production of siRNA involved in RNA interference21873635.IBAProcess
GO:0031053primary miRNA processing21873635.IBAProcess
GO:0031053primary miRNA processing14508493.15574589.IDAProcess
GO:0031053primary miRNA processing14508493.IMPProcess
GO:0031054pre-miRNA processing21873635.IBAProcess
GO:0042254ribosome biogenesis-IEAProcess
GO:0042803protein homodimerization activity15574589.IDAFunction
GO:0045589regulation of regulatory T cell differentiation-IEAProcess
GO:0046332SMAD binding18548003.IPIFunction
GO:0046872metal ion binding-IEAFunction
GO:0050727regulation of inflammatory response-IEAProcess
GO:0050829defense response to Gram-negative bacterium20180804.IDAProcess
GO:0050830defense response to Gram-positive bacterium20180804.IDAProcess
GO:0070412R-SMAD binding18548003.IPIFunction
GO:0070877microprocessor complex15574589.IDAComponent
GO:0070878primary miRNA binding18548003.IPIFunction
GO:0070878primary miRNA binding15574589.NASFunction
GO:0090502RNA phosphodiester bond hydrolysis, endonucleolytic-IEAProcess
GO:2000628regulation of miRNA metabolic process-IEAProcess
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