EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
20869096	Tumor necrosis is a new promising prognostic factor in colorectal cancer.	Hum Pathol	2010 Dec	Pollheimer MJ	doi: 10.1016/j.humpath.2010.04.018.
14871813	Loss of MSH3 protein expression is frequent in MLH1-deficient colorectal cancer and is associated with disease progression.	Cancer Res	2004 Feb 1	Plaschke J	-
26617824	MSH3 rs26279 polymorphism increases cancer risk: a meta-analysis.	Int J Clin Exp Pathol	2015 Sep 1	Miao HK	-
28656302	Inactivation of MSH3 by promoter methylation correlates with primary tumor stage in nasopharyngeal carcinoma.	Int J Mol Med	2017 Sep	Ni H	doi: 10.3892/ijmm.2017.3044
21974800	DNA repair gene polymorphisms and risk of early onset colorectal cancer in Lynch syndrome.	Cancer Epidemiol	2012 Apr	Reeves SG	doi: 10.1016/j.canep.2011.09.003
25966119	Correlation of MSH3 polymorphisms with response and survival in advanced non-small cell lung cancer patients treated with first-line platinum-based chemotherapy.	Genet Mol Res	2015 Apr 15	Xu XL	doi: 10.4238/2015.April.15.16.
17205513	Mismatch repair polymorphisms and the risk of colorectal cancer.	Int J Cancer	2007 Apr 1	Berndt SI	-
18355840	Mismatch repair gene MSH3 polymorphism is associated with the risk of sporadic prostate cancer.	J Urol	2008 May	Hirata H	doi: 10.1016/j.juro.2008.01.009
22249440	Aberrant protein expression and frequent allelic loss of MSH3 in colorectal cancer with low-level microsatellite instability.	Int J Colorectal Dis	2012 Jul	Plaschke J	doi: 10.1007/s00384-011-1408-0
25461668	Interleukin 6 alters localization of hMSH3, leading to DNA mismatch repair defects in colorectal cancer cells.	Gastroenterology	2015 Mar	Tseng-Rogenski SS	doi: 10.1053/j.gastro.2014.11.027
21128252	Association of low-risk MSH3 and MSH2 variant alleles with Lynch syndrome: probability of synergistic effects.	Int J Cancer	2011 Oct 1	Duraturo F	doi: 10.1002/ijc.25824
12014680	Frequent LOH at hMLH1, a highly variable SNP in hMSH3, and negligible coding instability in ovarian cancer.	Anticancer Res	2002 Mar-Apr	Arzimanoglou II	-
18922920	Genetic instability caused by loss of MutS homologue 3 in human colorectal cancer.	Cancer Res	2008 Oct 15	Haugen AC	doi: 10.1158/0008-5472.CAN-08-0002.
28093084	Association between DNA mismatch repair gene polymorphisms and platinum-based chemotherapy toxicity in non-small cell lung cancer patients.	Chin J Cancer	2017 Jan 16	Liu JY	doi: 10.1186/s40880-016-0175-2.

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr5	80767956	Missense_Mutation	NA	L640F	0.26
BLCA	chr5	80813700	Silent	novel	A924A	0.31
BLCA	chr5	80654760	Silent	novel	L11L	0.1
BLCA	chr5	80654784	Silent	NA	A19A	0.37
BLCA	chr5	80728856	Missense_Mutation	NA	Q487E	0.24
BLCA	chr5	80654760	Silent	rs564921007	L11L	0.24
BLCA	chr5	80854299	Missense_Mutation	NA	E995Q	0.27
BLCA	chr5	80670176	Nonsense_Mutation	NA	S220*	0.5
BRCA	chr5	80768937	Missense_Mutation	NA	H729Q	0.46
BRCA	chr5	80775735	Silent	NA	P765P	0.52
BRCA	chr5	80675096	Frame_Shift_Del	rs752887309	*K383Rfs32**	0.43
BRCA	chr5	80792804	Missense_Mutation	rs768150895	G872E	0.21
BRCA	chr5	80854130	Missense_Mutation	rs762638626	R938S	0.21
BRCA	chr5	80654760	Silent	rs564921007	L11L	0.38
BRCA	chr5	80778792	Frame_Shift_Ins	novel	*Q798Vfs12**	0.19
BRCA	chr5	80792788	Missense_Mutation	NA	I867V	0.31
BRCA	chr5	80813628	Silent	novel	G900G	0.05
BRCA	chr5	80875978	3'UTR	novel		0.13
CESC	chr5	80768026	Nonsense_Mutation	novel	Q664*	0.24
CESC	chr5	80675096	Frame_Shift_Del	rs752887309	*K383Rfs32**	0.37
CESC	chr5	80725532	Nonsense_Mutation	novel	E474*	0.31
CESC	chr5	80775728	Missense_Mutation	rs373251342	C763Y	0.81
COAD	chr5	80672257	Missense_Mutation	NA	E269G	0.35
COAD	chr5	80775711	Missense_Mutation	NA	K757N	0.33
COAD	chr5	80665211	Missense_Mutation	rs138381683	D143N	0.09
COAD	chr5	80875787	Missense_Mutation	rs145769847	M1113I	0.16
COAD	chr5	80792766	Frame_Shift_Del	NA	*N861Mfs6**	0.43
COAD	chr5	80670265	Missense_Mutation	rs762864714	V250M	0.25
COAD	chr5	80864865	Frame_Shift_Del	NA	*N1020Ifs40**	0.46
COAD	chr5	80665211	Missense_Mutation	rs138381683	D143N	0.19
COAD	chr5	80670263	Missense_Mutation	NA	C249Y	0.48
COAD	chr5	80778760	Missense_Mutation	NA	E787K	0.13
COAD	chr5	80767947	Missense_Mutation	NA	E637D	0.1
COAD	chr5	80864864	Frame_Shift_Ins	novel	*N1020Kfs17**	0.43
COAD	chr5	80761657	Silent	NA	L625L	0.28
COAD	chr5	80768981	Frame_Shift_Ins	novel	*V745Ifs28**	0.05
ESCA	chr5	80672826	Missense_Mutation	novel	A332V	0.89
GBM	chr5	80873174	Missense_Mutation	novel	I1063M	0.1
GBM	chr5	80761590	Missense_Mutation	novel	S603L	0.04
GBM	chr5	80787608	Missense_Mutation	novel	H827N	0.19
GBM	chr5	80864848	Silent	rs190963296	P1012P	0.2
GBM	chr5	80875895	3'UTR	novel		0.31
HNSC	chr5	80768097	Missense_Mutation	novel	K687N	0.49
HNSC	chr5	80654694	5'UTR	novel		0.2
HNSC	chr5	80656520	Missense_Mutation	NA	S116F	0.18
HNSC	chr5	80873115	Splice_Site	novel	X1044_splice	0.23
HNSC	chr5	80675095	Frame_Shift_Ins	NA	*N385Qfs19**	0.27
HNSC	chr5	80670183	Missense_Mutation	novel	N222K	0.26
HNSC	chr5	80875807	Missense_Mutation	novel	Q1120L	0.21
KIRC	chr5	80761677	Missense_Mutation	NA	K632T	0.14
KIRC	chr5	80813738	Frame_Shift_Ins	novel	*R938Yfs14**	0.07
KIRP	chr5	80675109	Missense_Mutation	NA	N385I	0.42
KIRP	chr5	80741549	Splice_Site	NA	X551_splice	0.33
KIRP	chr5	80864923	Frame_Shift_Ins	novel	*S1039Rfs14**	0.26
KIRP	chr5	80744583	Silent	NA	K577K	0.4
LGG	chr5	80768936	Missense_Mutation	novel	H729R	0.13
LGG	chr5	80656479	Missense_Mutation	NA	K102N	0.36
LIHC	chr5	80767975	Missense_Mutation	NA	H647D	0.07
LUAD	chr5	80873120	Silent	novel	A1045A	0.16
LUAD	chr5	80778790	Nonsense_Mutation	rs748016039	E797*	0.13
LUAD	chr5	80672244	In_Frame_Del	novel	I265del	0.07
LUAD	chr5	80778748	Missense_Mutation	rs778848549	P783T	0.11
LUAD	chr5	80654747	Missense_Mutation	novel	A7E	0.44
LUAD	chr5	80768970	Silent	novel	P740P	0.03
LUAD	chr5	80768925	Missense_Mutation	novel	E725D	0.23
LUAD	chr5	80744576	Missense_Mutation	rs762918386	K575R	0.32
LUAD	chr5	80787650	Missense_Mutation	novel	A841T	0.05
LUAD	chr5	80725473	Missense_Mutation	rs144798521	R454L	0.19
LUAD	chr5	80813615	Missense_Mutation	novel	G896V	0.07
LUAD	chr5	80744505	Splice_Site	novel	X552_splice	0.08
LUAD	chr5	80813599	Missense_Mutation	NA	V891L	0.13
LUSC	chr5	80728848	Splice_Region	novel		0.21
LUSC	chr5	80654720	5'UTR	novel		0.2
LUSC	chr5	80725472	Nonsense_Mutation	rs539295465	R454*	0.43
LUSC	chr5	80875784	Silent	rs772361271	T1112T	0.3
LUSC	chr5	80744505	Splice_Site	novel	X552_splice	0.34
LUSC	chr5	80665155	Missense_Mutation	novel	C124Y	0.22
LUSC	chr5	80778786	Silent	NA	L795L	0.12
LUSC	chr5	80875858	Missense_Mutation	novel	H1137L	0.18
LUSC	chr5	80813670	Silent	novel	I914I	0.24
LUSC	chr5	80854205	Missense_Mutation	novel	I963M	0.38
LUSC	chr5	80873182	Missense_Mutation	NA	R1066K	0.68
LUSC	chr5	80672341	Missense_Mutation	novel	L297P	0.37
MESO	chr5	80665253	Nonsense_Mutation	novel	Q157*	0.36
OV	chr5	80672325	Missense_Mutation	NA	V292L	0.41
OV	chr5	80792804	Missense_Mutation	NA	G872V	0.17
PAAD	chr5	80768950	Nonsense_Mutation	rs770330684	R734*	0.2
PAAD	chr5	80854223	Missense_Mutation	novel	Q969H	0.21
PRAD	chr5	80672347	Missense_Mutation	novel	A299V	0.25
PRAD	chr5	80656415	Missense_Mutation	NA	T81K	0.07
PRAD	chr5	80665313	Missense_Mutation	rs372073889	A177T	0.4
PRAD	chr5	80656441	Missense_Mutation	novel	P90S	0.39
PRAD	chr5	80864942	Missense_Mutation	novel	G1044C	0.42
READ	chr5	80670291	Missense_Mutation	novel	F258L	0.38
READ	chr5	80725547	Missense_Mutation	NA	D479Y	0.3
READ	chr5	80875920	3'UTR	novel		0.53
READ	chr5	80665150	Missense_Mutation	NA	K122N	0.3
READ	chr5	80873231	Missense_Mutation	NA	I1082M	0.39
SARC	chr5	80672333	Silent	novel	V294V	0.33
SARC	chr5	80768841	Silent	novel	G697G	0.25
SKCM	chr5	80741536	Silent	NA	I547I	0.14
SKCM	chr5	80674999	Silent	NA	I348I	0.53
SKCM	chr5	80678989	Silent	NA	S412S	0.1
SKCM	chr5	80656441	Missense_Mutation	rs772032731	P90T	0.4
SKCM	chr5	80768968	Missense_Mutation	NA	P740S	0.15
SKCM	chr5	80672860	Splice_Site	NA	X343_splice	0.33
SKCM	chr5	80775754	Missense_Mutation	NA	G772R	0.22
SKCM	chr5	80761635	Missense_Mutation	NA	L618W	0.3
SKCM	chr5	80875803	Silent	NA	L1119L	0.45
SKCM	chr5	80778746	Missense_Mutation	NA	S782F	0.44
SKCM	chr5	80761622	Missense_Mutation	NA	H614Y	0.18
SKCM	chr5	80725477	Silent	rs771995449	V455V	0.14
SKCM	chr5	80873164	Missense_Mutation	novel	T1060I	0.25
STAD	chr5	80675096	Frame_Shift_Del	rs752887309	*K383Rfs32**	0.38
STAD	chr5	80768922	Silent	rs541680738	D724D	0.31
STAD	chr5	80768923	Missense_Mutation	rs200612739	E725K	0.35
STAD	chr5	80813632	Missense_Mutation	rs763041578	K902Q	0.37
STAD	chr5	80679002	Missense_Mutation	rs143211109	R417W	0.12
STAD	chr5	80675095	Frame_Shift_Ins	NA	*N385Qfs19**	0.37
STAD	chr5	80787576	Missense_Mutation	NA	E816G	0.14
STAD	chr5	80675096	Frame_Shift_Del	rs752887309	*K383Rfs32**	0.64
STAD	chr5	80670206	Missense_Mutation	rs763873895	T230M	0.35
STAD	chr5	80778788	Missense_Mutation	rs542104580	R796Q	0.4
STAD	chr5	80670187	Missense_Mutation	rs748207601	R224W	0.26
STAD	chr5	80854129	Splice_Site	novel	X938_splice	0.06
STAD	chr5	80778822	Nonsense_Mutation	NA	W807*	0.29
STAD	chr5	80813614	Missense_Mutation	rs777054839	G896R	0.23
THCA	chr5	80873275	Missense_Mutation	novel	I1097K	0.1
THCA	chr5	80873277	Frame_Shift_Ins	novel	*N1098Rfs19**	0.1
THYM	chr5	80854257	Missense_Mutation	novel	T981A	0.38
UCEC	chr5	80775711	Missense_Mutation	NA	K757N	0.31
UCEC	chr5	80792753	Missense_Mutation	NA	R855I	0.2
UCEC	chr5	80728931	Nonsense_Mutation	NA	E512*	0.35
UCEC	chr5	80787650	Missense_Mutation	novel	A841T	0.28
UCEC	chr5	80725547	Missense_Mutation	NA	D479Y	0.38
UCEC	chr5	80670250	Missense_Mutation	novel	D245Y	0.45
UCEC	chr5	80813709	Silent	rs753651533	A927A	0.2
UCEC	chr5	80675096	Frame_Shift_Del	rs752887309	*K383Rfs32**	0.36
UCEC	chr5	80675096	Frame_Shift_Del	rs752887309	*K383Rfs32**	0.51
UCEC	chr5	80778781	Missense_Mutation	novel	Q794E	0.2
UCEC	chr5	80741463	Splice_Site	novel	X523_splice	0.09
UCEC	chr5	80768904	Missense_Mutation	novel	E718D	0.1
UCEC	chr5	80873265	Missense_Mutation	novel	E1094K	0.04
UCEC	chr5	80873266	Nonsense_Mutation	novel	E1094_G1095ins*	0.04
UCEC	chr5	80672779	Missense_Mutation	novel	K316N	0.04
UCEC	chr5	80654903	Missense_Mutation	novel	A59G	0.21
UCEC	chr5	80675096	Frame_Shift_Del	rs752887309	*K383Rfs32**	0.47
UCEC	chr5	80873176	Missense_Mutation	novel	A1064V	0.05
UCEC	chr5	80875783	Missense_Mutation	rs576204286	T1112M	0.16
UCEC	chr5	80864861	Frame_Shift_Del	novel	*L1017Rfs19**	0.03
UCEC	chr5	80864862	Frame_Shift_Ins	novel	*E1018Kfs44**	0.03
UCEC	chr5	80672323	Missense_Mutation	novel	F291S	0.39
UCEC	chr5	80761575	Missense_Mutation	rs757559761	S598L	0.52
UCEC	chr5	80656417	Nonsense_Mutation	novel	E82*	0.37
UCEC	chr5	80728910	Missense_Mutation	novel	A505T	0.28
UCEC	chr5	80768950	Nonsense_Mutation	rs770330684	R734*	0.37
UCEC	chr5	80864921	Missense_Mutation	novel	D1037N	0.35
UCEC	chr5	80675096	Frame_Shift_Del	rs752887309	*K383Rfs32**	0.52
UCEC	chr5	80761640	Missense_Mutation	rs200337887	D620N	0.39
UCEC	chr5	80854134	Missense_Mutation	novel	G940S	0.32
UCEC	chr5	80675096	Frame_Shift_Del	rs752887309	*K383Rfs32**	0.37
UCEC	chr5	80725473	Missense_Mutation	rs144798521	R454Q	0.44
UCEC	chr5	80873281	Missense_Mutation	rs545543643	T1099M	0.53
UCEC	chr5	80854235	Silent	novel	I973I	0.52
UCEC	chr5	80728931	Nonsense_Mutation	NA	E512*	0.5
UCEC	chr5	80875968	3'UTR	novel		0.44
UCEC	chr5	80768840	Missense_Mutation	NA	G697V	0.07
UCEC	chr5	80672796	Missense_Mutation	novel	R322I	0.26
UCEC	chr5	80767951	Missense_Mutation	novel	F639V	0.44
UCEC	chr5	80873231	Missense_Mutation	NA	I1082M	0.41
UCEC	chr5	80675096	Frame_Shift_Del	rs752887309	*K383Rfs32**	0.66
UCEC	chr5	80768930	Missense_Mutation	rs148896355	R727Q	0.35
UCEC	chr5	80675096	Frame_Shift_Del	rs752887309	*K383Rfs32**	0.56
UCEC	chr5	80768922	Silent	rs541680738	D724D	0.47
UCEC	chr5	80675096	Frame_Shift_Del	rs752887309	*K383Rfs32**	0.55
UCEC	chr5	80725468	Silent	novel	R452R	0.22
UCEC	chr5	80725546	Missense_Mutation	novel	K478N	0.56
UCEC	chr5	80873121	Missense_Mutation	rs144603433	A1046T	0.35
UCEC	chr5	80741483	Missense_Mutation	novel	S530R	0.27
UCEC	chr5	80873254	Frame_Shift_Ins	novel	*E1092Rfs24**	0.21
UCEC	chr5	80675096	Frame_Shift_Del	rs752887309	*K383Rfs32**	0.36
UCEC	chr5	80675096	Frame_Shift_Del	rs752887309	*K383Rfs32**	0.62
UCEC	chr5	80768935	Missense_Mutation	novel	H729Y	0.28
UCEC	chr5	80675096	Frame_Shift_Del	rs752887309	*K383Rfs32**	0.35
UCEC	chr5	80675096	Frame_Shift_Del	rs752887309	*K383Rfs32**	0.34
UCEC	chr5	80768961	Frame_Shift_Del	novel	*N739Ifs7**	0.12
UCEC	chr5	80875984	3'UTR	novel		0.37
UCEC	chr5	80873202	Missense_Mutation	novel	A1073T	0.45
UCEC	chr5	80675096	Frame_Shift_Del	rs752887309	*K383Rfs32**	0.42
UCEC	chr5	80854287	Missense_Mutation	NA	Y991H	0.18
UCEC	chr5	80728869	Missense_Mutation	novel	G491D	0.08
UCEC	chr5	80767982	Missense_Mutation	NA	K649T	0.17
UCEC	chr5	80675096	Frame_Shift_Del	rs752887309	*K383Rfs32**	0.76
UCEC	chr5	80656451	Missense_Mutation	NA	N93T	0.27
UCEC	chr5	80665199	Nonsense_Mutation	NA	E139*	0.28
UCEC	chr5	80768083	Nonsense_Mutation	NA	E683*	0.2
UCEC	chr5	80854211	Missense_Mutation	NA	K965N	0.3
UCEC	chr5	80670140	Missense_Mutation	novel	T208I	0.18
UCEC	chr5	80725478	Missense_Mutation	novel	E456K	0.21
UCEC	chr5	80787578	Missense_Mutation	novel	H817Y	0.28
UCEC	chr5	80876030	3'UTR	novel		0.32
UCEC	chr5	80768042	Missense_Mutation	rs372048303	R669Q	0.36
UCEC	chr5	80875889	3'UTR	novel		0.26

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
CHOL	DEL	0.1944	0.16947
LUSC	DEL	0.6627	0.002071
MESO	DEL	0.1264	0.20184
OV	DEL	0.6753	3.6941e-88
PAAD	DEL	0.1359	0.0001774
THCA	DEL	0	0.23456

Survival Analysis

Cancer	P-value	Q-value
STAD	0.015	Kaplan-Meier Survival Analysis
MESO	0.00097	Kaplan-Meier Survival Analysis
ACC	0.045	Kaplan-Meier Survival Analysis
SKCM	0.0007	Kaplan-Meier Survival Analysis
COAD	0.01	Kaplan-Meier Survival Analysis
PCPG	0.031	Kaplan-Meier Survival Analysis
READ	0.0076	Kaplan-Meier Survival Analysis
KICH	0.0031	Kaplan-Meier Survival Analysis
LGG	0.016	Kaplan-Meier Survival Analysis
THCA	0.017	Kaplan-Meier Survival Analysis
LUAD	0.03	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Gene Ontology

Description

Ensembl ID: ENSG00000113318 (Gene tree)
Gene ID: 4437
Gene Symbol: MSH3
Alias: DUP|MRP1
Full Name: mutS homolog 3
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 222,168 bases
Position: chr5:80,654,648-80,876,815
Accession: 7326
RBP type: non-canonical RBP
Summary: The protein encoded by this gene forms a heterodimer with MSH2 to form MutS beta, part of the post-replicative DNA mismatch repair system. MutS beta initiates mismatch repair by binding to a mismatch and then forming a complex with MutL alpha heterodimer. This gene contains a polymorphic 9 bp tandem repeat sequence in the first exon. The repeat is present 6 times in the reference genome sequence and 3-7 repeats have been reported. Defects in this gene are a cause of susceptibility to endometrial cancer. [provided by RefSeq, Mar 2011]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
18765568	Recruitment of mismatch repair proteins to the site of DNA damage in human cells.	J Cell Sci	2008 Oct 1	Hong Z	doi: 10.1242/jcs.026393

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000512258	MSH3-202	677	-	-	- (aa)	-	-
ENST00000265081	MSH3-201	4092	-	ENSP00000265081	1137 (aa)	-	P20585
ENST00000512531	MSH3-203	531	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000113318's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa01524	Platinum drug resistance	KEGG
hsa03430	Mismatch repair	KEGG
hsa05200	Pathways in cancer	KEGG
hsa05210	Colorectal cancer	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000113318	Intercellular Adhesion Molecule-1	3.69127265950623E-5	17903293
ENSG00000113318	Intercellular Adhesion Molecule-1	5.25469189570592E-5	17903293
ENSG00000113318	Echocardiography	6.74801256643764E-5	17903301

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000113318	rs7709909	5	80705351	?	HDL cholesterol change in response to fenofibrate in statin-treated type 2 diabetes	28736931	unit decrease	0.045	EFO_0007805\|GO_1903491\|EFO_0001360\|GO_1901557
ENSG00000113318	rs190085132	5	80808875	?	Rheumatic fever	28928442	[0.19-0.5] unit decrease	0.3442	EFO_0008416
ENSG00000113318	rs78621558	5	80716916	?	Huntington's disease progression	28642124			Orphanet_399\|EFO_0008336
ENSG00000113318	rs1650697	5	80654962	?	Reaction time	29844566	[0.0043-0.0112] unit decrease	0.0077569	EFO_0008393

Protein-Protein Interaction (PPI)

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* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000406	double-strand/single-strand DNA junction binding	21873635.	IBA	Function
GO:0000710	meiotic mismatch repair	21873635.	IBA	Process
GO:0000735	removal of nonhomologous ends	21873635.	IBA	Process
GO:0003684	damaged DNA binding	21873635.	IBA	Function
GO:0003697	single-stranded DNA binding	11809883.	IDA	Function
GO:0005515	protein binding	8942985.9774676.11005803.14657349.16025128.19377479.22179786.25416956.	IPI	Function
GO:0005524	ATP binding	21873635.	IBA	Function
GO:0005634	nucleus	26300262.	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0006281	DNA repair	8942985.	IDA	Process
GO:0006298	mismatch repair	21873635.	IBA	Process
GO:0006298	mismatch repair	8782829.	IMP	Process
GO:0006298	mismatch repair	-	TAS	Process
GO:0006312	mitotic recombination	21873635.	IBA	Process
GO:0007131	reciprocal meiotic recombination	21873635.	IBA	Process
GO:0008094	DNA-dependent ATPase activity	21873635.	IBA	Function
GO:0016020	membrane	19946888.	HDA	Component
GO:0019899	enzyme binding	11427529.26300262.	IPI	Function
GO:0030983	mismatched DNA binding	8942985.	IDA	Function
GO:0032137	guanine/thymine mispair binding	21873635.	IBA	Function
GO:0032137	guanine/thymine mispair binding	11809883.	IDA	Function
GO:0032139	dinucleotide insertion or deletion binding	8942985.	IDA	Function
GO:0032142	single guanine insertion binding	8942985.	IDA	Function
GO:0032143	single thymine insertion binding	21873635.	IBA	Function
GO:0032181	dinucleotide repeat insertion binding	8942985.	IDA	Function
GO:0032300	mismatch repair complex	21873635.	IBA	Component
GO:0032302	MutSbeta complex	21873635.	IBA	Component
GO:0032302	MutSbeta complex	8942985.	IDA	Component
GO:0032357	oxidized purine DNA binding	21873635.	IBA	Function
GO:0032357	oxidized purine DNA binding	11756455.	IDA	Function
GO:0042803	protein homodimerization activity	8942985.	IDA	Function
GO:0043111	replication fork arrest	21873635.	IBA	Process
GO:0043570	maintenance of DNA repeat elements	21873635.	IBA	Process
GO:0043570	maintenance of DNA repeat elements	16388310.	IMP	Process
GO:0045910	negative regulation of DNA recombination	17715146.	IDA	Process
GO:0051096	positive regulation of helicase activity	21873635.	IBA	Process
GO:0051096	positive regulation of helicase activity	17715146.	IDA	Process

EuRBPDB

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Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Gene Ontology

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Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.