EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
30873822	Modulation of Mitochondrial ERβ Expression Inhibits Triple-Negative Breast Cancer Tumor Progression by Activating Mitochondrial Function.	Cell Physiol Biochem	2019	Song IS	doi: 10.33594/000000034
17934217	Association of mortalin (HSPA9) with liver cancer metastasis and prediction for early tumor recurrence.	Mol Cell Proteomics	2008 Feb	Yi X	-
23959801	A mortalin/HSPA9-mediated switch in tumor-suppressive signaling of Raf/MEK/extracellular signal-regulated kinase.	Mol Cell Biol	2013 Oct	Wu PK	doi: 10.1128/MCB.00021-13
21233847	Mortalin-p53 interaction in cancer cells is stress dependent and constitutes a selective target for cancer therapy.	Cell Death Differ	2011 Jun	Lu WJ	doi: 10.1038/cdd.2010.177
19739077	Mortalin inhibitors sensitize K562 leukemia cells to complement-dependent cytotoxicity.	Int J Cancer	2010 Mar 15	Pilzer D	doi: 10.1002/ijc.24888.
26955804	The clinicopathological significance of Mortalin overexpression in invasive ductal carcinoma of breast.	J Exp Clin Cancer Res	2016 Mar 9	Jin H	doi: 10.1186/s13046-016-0316-0.
28349826	Mortalin overexpression predicts poor prognosis in early stage of non-small cell lung cancer.	Tumour Biol	2017 Mar	Sun J	doi: 10.1177/1010428317695918.
25012652	Identification and functional characterization of nuclear mortalin in human carcinogenesis.	J Biol Chem	2014 Sep 5	Ryu J	doi: 10.1074/jbc.M114.565929
24050266	Molecular interactions of Bcl-2 and Bcl-xL with mortalin: identification and functional characterization.	Biosci Rep	2013 Oct 16	Saxena N	doi: 10.1042/BSR20130034.
23665506	Inhibition of mortalin expression reverses cisplatin resistance and attenuates growth of ovarian cancer cells.	Cancer Lett	2013 Aug 9	Yang L	doi: 10.1016/j.canlet.2013.05.004
16425258	Upregulation of mortalin/mthsp70/Grp75 contributes to human carcinogenesis.	Int J Cancer	2006 Jun 15	Wadhwa R	-
23828548	Mortalin is a prognostic factor of gastric cancer with normal p53 function.	Gastric Cancer	2014 Apr	Ando K	doi: 10.1007/s10120-013-0279-1
24625977	Ubiquitin-like (UBX)-domain-containing protein, UBXN2A, promotes cell death by interfering with the p53-Mortalin interactions in colon cancer cells.	Cell Death Dis	2014 Mar 13	Sane S	doi: 10.1038/cddis.2014.100.
21496427	[RNA Interference targeting GRP75 decreases cisplatin resistance in human lung adenocarcinoma cell].	Zhongguo Fei Ai Za Zhi	2011 Apr	Shi S	doi: 10.3779/j.issn.1009-3419.2011.04.01.
23319326	Elevated levels of mitochondrial mortalin and cytosolic HSP70 in blood as risk factors in patients with colorectal cancer.	Int J Cancer	2013 Jul 15	Rozenberg P	doi: 10.1002/ijc.28029
30776464	Mortalin is a distinct bio-marker and prognostic factor in serous ovarian carcinoma.	Gene	2019 May 15	Xu M	doi: 10.1016/j.gene.2019.02.033

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr5	138573846	Missense_Mutation	novel	E49K	0.28
BLCA	chr5	138571050	Missense_Mutation	novel	R107Q	0.22
BLCA	chr5	138566680	Missense_Mutation	NA	Q306H	0.11
BLCA	chr5	138567010	Missense_Mutation	novel	F290L	0.32
BLCA	chr5	138560004	Nonsense_Mutation	novel	Q424*	0.58
BLCA	chr5	138556581	Silent	novel	L611L	0.34
BLCA	chr5	138556551	Silent	novel	L621L	0.07
BLCA	chr5	138557344	Intron	novel		0.61
BLCA	chr5	138567005	Missense_Mutation	novel	R292T	0.18
BRCA	chr5	138555896	3'UTR	novel		0.42
BRCA	chr5	138561721	Silent	novel	T347T	0.06
BRCA	chr5	138573848	Nonsense_Mutation	NA	S48*	0.22
BRCA	chr5	138556496	Missense_Mutation	NA	L640V	0.35
BRCA	chr5	138556982	Intron	novel		0.29
BRCA	chr5	138557987	Splice_Site	NA	X506_splice	0.22
BRCA	chr5	138566636	Missense_Mutation	NA	S321L	0.27
BRCA	chr5	138555959	3'UTR	rs534609124		0.29
BRCA	chr5	138566715	Frame_Shift_Del	rs772570880	V296*	0.19
CESC	chr5	138561712	Silent	novel	Q350Q	0.55
CESC	chr5	138568965	Missense_Mutation	NA	Q165H	0.11
CESC	chr5	138556857	Nonsense_Mutation	NA	E580*	0.26
CESC	chr5	138567655	Silent	NA	Q201Q	0.86
CESC	chr5	138556470	Silent	rs148730345	F648F	0.48
CHOL	chr5	138557890	In_Frame_Del	novel	D536_K537del	0.1
COAD	chr5	138557465	Missense_Mutation	NA	K555N	0.2
COAD	chr5	138567715	Silent	novel	Y181Y	0.3
COAD	chr5	138559968	Silent	novel	L436L	0.23
COAD	chr5	138567470	Missense_Mutation	NA	K234T	0.16
COAD	chr5	138559986	Missense_Mutation	novel	G430S	0.35
COAD	chr5	138561588	Missense_Mutation	novel	M392V	0.4
COAD	chr5	138567030	Missense_Mutation	rs776644009	R284W	0.29
COAD	chr5	138575250	Silent	NA	A23A	0.47
COAD	chr5	138557363	Intron	novel		0.11
COAD	chr5	138555959	3'UTR	rs534609124		0.31
COAD	chr5	138556108	Missense_Mutation	novel	S657P	0.06
COAD	chr5	138561640	Silent	novel	E374E	0.41
COAD	chr5	138561618	Nonsense_Mutation	NA	E382*	0.12
ESCA	chr5	138573781	In_Frame_Ins	novel	M70delinsIT	0.23
ESCA	chr5	138559945	Silent	novel	L443L	0.25
GBM	chr5	138559918	Silent	novel	G452G	0.11
HNSC	chr5	138571010	Silent	novel	T120T	0.26
HNSC	chr5	138556988	Intron	novel		0.57
HNSC	chr5	138567016	Missense_Mutation	novel	K288N	0.23
HNSC	chr5	138556933	Intron	novel		0.11
HNSC	chr5	138575363	5'UTR	novel		0.12
KIRC	chr5	138566670	Nonsense_Mutation	novel	E310*	0.26
KIRC	chr5	138567712	Silent	rs751963587	L182L	0.33
KIRC	chr5	138575287	Missense_Mutation	NA	R11L	0.38
KIRC	chr5	138560078	Missense_Mutation	NA	V399A	0.25
KIRP	chr5	138567527	Missense_Mutation	NA	N215S	0.09
KIRP	chr5	138569044	Frame_Shift_Del	novel	*N139Mfs33**	0.43
LGG	chr5	138559976	Missense_Mutation	novel	T433M	0.1
LGG	chr5	138570991	Nonsense_Mutation	NA	R127*	0.11
LIHC	chr5	138560027	Missense_Mutation	novel	A416V	0.3
LIHC	chr5	138557932	Missense_Mutation	NA	I524V	0.15
LIHC	chr5	138561612	Missense_Mutation	novel	I384L	0.26
LUAD	chr5	138556831	Silent	novel	I588I	0.47
LUAD	chr5	138556916	Intron	novel		0.14
LUAD	chr5	138561583	Silent	novel	P393P	0.15
LUSC	chr5	138567026	Missense_Mutation	novel	H285L	0.58
LUSC	chr5	138569017	Missense_Mutation	novel	S148C	0.43
LUSC	chr5	138568922	Splice_Region	novel		0.18
LUSC	chr5	138571001	Silent	novel	L123L	0.12
LUSC	chr5	138568952	Missense_Mutation	rs760801530	V170M	0.23
LUSC	chr5	138556920	Intron	novel		0.21
LUSC	chr5	138571120	Missense_Mutation	NA	A84S	0.38
LUSC	chr5	138574157	Intron	novel		0.54
LUSC	chr5	138558640	Silent	novel	A476A	0.44
LUSC	chr5	138571015	Missense_Mutation	NA	A119T	0.08
LUSC	chr5	138571063	Missense_Mutation	novel	M103V	0.07
LUSC	chr5	138556920	Intron	novel		0.82
OV	chr5	138571088	Silent	novel	T94T	0.06
OV	chr5	138556009	3'UTR	novel		0.2
OV	chr5	138560056	Silent	novel	A406A	0.42
OV	chr5	138555959	3'UTR	rs534609124		0.31
PAAD	chr5	138571046	Missense_Mutation	novel	Q108H	0.05
PRAD	chr5	138556519	Frame_Shift_Del	novel	*N632Yfs2**	0.48
READ	chr5	138557409	Missense_Mutation	rs372075340	R574Q	0.35
READ	chr5	138559869	Missense_Mutation	novel	S469G	0.25
READ	chr5	138571046	Silent	rs754498058	Q108Q	0.53
READ	chr5	138556974	Intron	novel		0.4
SKCM	chr5	138561042	Intron	rs555432734		0.3
SKCM	chr5	138571109	Silent	NA	T87T	0.41
SKCM	chr5	138571001	Silent	NA	L123L	0.41
STAD	chr5	138566666	Missense_Mutation	NA	A311G	0.06
STAD	chr5	138557974	Missense_Mutation	rs752447855	P510S	0.23
STAD	chr5	138556470	Silent	rs148730345	F648F	0.32
STAD	chr5	138567658	Silent	rs762248139	S200S	0.35
STAD	chr5	138558628	Silent	rs149852902	T480T	0.1
STAD	chr5	138556458	Silent	NA	Y652Y	0.29
STAD	chr5	138559887	Missense_Mutation	NA	T463A	0.26
STAD	chr5	138555964	3'UTR	novel		0.09
THYM	chr5	138556932	Intron	novel		0.44
UCEC	chr5	138567456	Missense_Mutation	rs758625540	V239F	0.27
UCEC	chr5	138570981	Missense_Mutation	NA	D130G	0.27
UCEC	chr5	138567078	Missense_Mutation	NA	N268H	0.22
UCEC	chr5	138556799	Missense_Mutation	novel	F599C	0.33
UCEC	chr5	138556824	Missense_Mutation	rs761237709	D591N	0.1
UCEC	chr5	138557042	Intron	novel		0.23
UCEC	chr5	138573837	Missense_Mutation	novel	K52E	0.34
UCEC	chr5	138566719	Splice_Site	novel	X294_splice	0.07
UCEC	chr5	138556863	Nonsense_Mutation	rs757156840	R578*	0.43
UCEC	chr5	138557261	Intron	novel		0.3
UCEC	chr5	138561755	Missense_Mutation	novel	S336Y	0.17
UCEC	chr5	138559888	Silent	novel	T462T	0.08
UCEC	chr5	138561760	Missense_Mutation	novel	M334I	0.21
UCEC	chr5	138556774	Missense_Mutation	novel	E607D	0.05
UCEC	chr5	138557271	Intron	NA		0.13
UCEC	chr5	138557409	Missense_Mutation	rs372075340	R574Q	0.42
UCEC	chr5	138573761	Splice_Site	novel	X76_splice	0.44
UCEC	chr5	138575251	Missense_Mutation	novel	A23V	0.39
UCEC	chr5	138570990	Missense_Mutation	rs375941962	R127Q	0.61
UCEC	chr5	138555832	3'UTR	novel		0.42
UCEC	chr5	138556824	Missense_Mutation	rs761237709	D591N	0.5
UCEC	chr5	138574067	Splice_Site	NA	X47_splice	0.33
UCEC	chr5	138559912	Silent	novel	F454F	0.39
UCEC	chr5	138555871	3'UTR	novel		0.29
UCEC	chr5	138557378	Intron	novel		0.18
UCEC	chr5	138575357	5'UTR	rs758162046		0.42
UCEC	chr5	138571056	Missense_Mutation	novel	A105V	0.48
UCEC	chr5	138557262	Intron	novel		0.38
UCEC	chr5	138556566	Silent	NA	S616S	0.3
UCEC	chr5	138557463	Missense_Mutation	novel	D556V	0.44
UCEC	chr5	138561064	Intron	novel		0.33
UCEC	chr5	138567560	Missense_Mutation	NA	A204D	0.21
UCEC	chr5	138557432	Missense_Mutation	NA	E566D	0.44
UCEC	chr5	138567667	Missense_Mutation	NA	F197L	0.33
UCEC	chr5	138567080	Missense_Mutation	novel	T267I	0.3
UCEC	chr5	138566672	Missense_Mutation	novel	R309Q	0.4
UCEC	chr5	138557084	Intron	novel		0.36
UCS	chr5	138556026	3'UTR	novel		0.38

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
KIRP	AMP	0.1076	0.069756
KIRP	DEL	0.0382	0.11554
LAML	DEL	0.089	1.2971e-07
LUSC	DEL	0.6188	0.002071
MESO	DEL	0.1264	0.20184
PRAD	AMP	0.0305	0.16448
SKCM	DEL	0.2916	2.2081e-08
THCA	AMP	0.0361	0.075436
THCA	DEL	0	0.23456

Survival Analysis

Cancer	P-value	Q-value
THYM	0.035	Kaplan-Meier Survival Analysis
KIRC	0.0028	Kaplan-Meier Survival Analysis
MESO	0.047	Kaplan-Meier Survival Analysis
ACC	0.0025	Kaplan-Meier Survival Analysis
UCS	0.027	Kaplan-Meier Survival Analysis
LUSC	0.028	Kaplan-Meier Survival Analysis
BRCA	0.00042	Kaplan-Meier Survival Analysis
COAD	0.017	Kaplan-Meier Survival Analysis
BLCA	0.013	Kaplan-Meier Survival Analysis
READ	0.022	Kaplan-Meier Survival Analysis
KICH	0.023	Kaplan-Meier Survival Analysis
UCEC	0.036	Kaplan-Meier Survival Analysis
LUAD	0.00072	Kaplan-Meier Survival Analysis
UVM	0.0078	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

Phenotypes

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000113013 (Gene tree)
Gene ID: 3313
Gene Symbol: HSPA9
Alias: GRP75|PBP74|mot-2|mthsp75|HSPA9B
Full Name: heat shock protein family A (Hsp70) member 9
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 21,969 bases
Position: chr5:138,553,756-138,575,724
Accession: 5244
RBP type: non-canonical RBP
Summary: This gene encodes a member of the heat shock protein 70 gene family. The encoded protein is primarily localized to the mitochondria but is also found in the endoplasmic reticulum, plasma membrane and cytoplasmic vesicles. This protein is a heat-shock cognate protein. This protein plays a role in cell proliferation, stress response and maintenance of the mitochondria. A pseudogene of this gene is found on chromosome 2.[provided by RefSeq, May 2010]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
27453046	Comprehensive Identification of RNA-Binding Domains in Human Cells	RIC & Hela	2016 Aug 18	Castello A	DOI: 10.1016/j.molcel.2016.06.029

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000524109	HSPA9-213	1175	-	-	- (aa)	-	-
ENST00000504902	HSPA9-204	887	-	ENSP00000421311	100 (aa)	-	H0Y8K0
ENST00000649692	HSPA9-216	2725	-	-	- (aa)	-	-
ENST00000507115	HSPA9-208	663	-	ENSP00000423759	42 (aa)	-	D6RCD7
ENST00000508003	HSPA9-210	582	-	-	- (aa)	-	-
ENST00000649578	HSPA9-215	4319	-	ENSP00000497906	180 (aa)	-	-
ENST00000649126	HSPA9-214	4727	-	ENSP00000496940	679 (aa)	-	UPI000012BA4E
ENST00000506477	HSPA9-206	664	-	-	- (aa)	-	-
ENST00000501917	HSPA9-202	285	-	ENSP00000497974	43 (aa)	-	-
ENST00000523929	HSPA9-212	780	-	ENSP00000429475	163 (aa)	-	H0YBG6
ENST00000507886	HSPA9-209	551	-	ENSP00000423098	62 (aa)	-	D6RA73
ENST00000505110	HSPA9-205	518	-	ENSP00000420944	38 (aa)	-	D6RDH7
ENST00000297185	HSPA9-201	2825	-	ENSP00000297185	679 (aa)	-	P38646
ENST00000512328	HSPA9-211	482	-	ENSP00000421892	102 (aa)	-	H0Y8S0
ENST00000504810	HSPA9-203	584	-	ENSP00000425598	95 (aa)	-	D6RJI2
ENST00000507097	HSPA9-207	1796	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000113013's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa03018	RNA degradation	KEGG
hsa05152	Tuberculosis	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000113013	Platelet Function Tests	1.3345900E-005	-

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000113013's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000113013	HSPA9	100	82.258	WBGene00002010	hsp-6	97	76.682	Caenorhabditis_elegans
ENSG00000113013	HSPA9	100	90.323	FBgn0001220	Hsc70-5	95	76.677	Drosophila_melanogaster
ENSG00000113013	HSPA9	100	100.000	ENSMUSG00000024359	Hspa9	100	98.380	Mus_musculus
ENSG00000113013	HSPA9	98	77.049	YJR045C	SSC1	96	65.773	Saccharomyces_cerevisiae

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003723	RNA binding	22658674.22681889.	HDA	Function
GO:0005515	protein binding	10411904.15520177.15657067.17184779.20029029.20153329.20195357.20668094.22340593.22726440.23541579.24189400.24606901.25416956.26702583.28380382.	IPI	Function
GO:0005524	ATP binding	21873635.	IBA	Function
GO:0005730	nucleolus	-	IEA	Component
GO:0005737	cytoplasm	21873635.	IBA	Component
GO:0005739	mitochondrion	21873635.	IBA	Component
GO:0005739	mitochondrion	7896880.26702583.	IDA	Component
GO:0005739	mitochondrion	16130169.	TAS	Component
GO:0005759	mitochondrial matrix	-	TAS	Component
GO:0005925	focal adhesion	21423176.	HDA	Component
GO:0006986	response to unfolded protein	21873635.	IBA	Process
GO:0016226	iron-sulfur cluster assembly	26702583.	IMP	Process
GO:0016887	ATPase activity	21873635.	IBA	Function
GO:0030218	erythrocyte differentiation	21123823.	IMP	Process
GO:0031072	heat shock protein binding	21873635.	IBA	Function
GO:0031625	ubiquitin protein ligase binding	19725078.21753002.	IPI	Function
GO:0034605	cellular response to heat	21873635.	IBA	Process
GO:0034620	cellular response to unfolded protein	21873635.	IBA	Process
GO:0035722	interleukin-12-mediated signaling pathway	-	TAS	Process
GO:0042026	protein refolding	21873635.	IBA	Process
GO:0042623	ATPase activity, coupled	21873635.	IBA	Function
GO:0042645	mitochondrial nucleoid	18063578.	IDA	Component
GO:0043066	negative regulation of apoptotic process	16130169.	TAS	Process
GO:0044183	protein binding involved in protein folding	21873635.	IBA	Function
GO:0045646	regulation of erythrocyte differentiation	26702583.	IMP	Process
GO:0045647	negative regulation of erythrocyte differentiation	21123823.	IMP	Process
GO:0051082	unfolded protein binding	21873635.	IBA	Function
GO:0051082	unfolded protein binding	16130169.	TAS	Function
GO:0051085	chaperone cofactor-dependent protein refolding	21873635.	IBA	Process
GO:0051787	misfolded protein binding	21873635.	IBA	Function
GO:0070062	extracellular exosome	20458337.	HDA	Component

EuRBPDB

Note: to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

Phenotypes

PPI

Orthologs

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.