EuRBPDB

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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
30873822Modulation of Mitochondrial ERβ Expression Inhibits Triple-Negative Breast Cancer Tumor Progression by Activating Mitochondrial Function.Cell Physiol Biochem2019Song ISdoi: 10.33594/000000034
17934217Association of mortalin (HSPA9) with liver cancer metastasis and prediction for early tumor recurrence.Mol Cell Proteomics2008 FebYi X-
23959801A mortalin/HSPA9-mediated switch in tumor-suppressive signaling of Raf/MEK/extracellular signal-regulated kinase.Mol Cell Biol2013 OctWu PKdoi: 10.1128/MCB.00021-13
21233847Mortalin-p53 interaction in cancer cells is stress dependent and constitutes a selective target for cancer therapy.Cell Death Differ2011 JunLu WJdoi: 10.1038/cdd.2010.177
19739077Mortalin inhibitors sensitize K562 leukemia cells to complement-dependent cytotoxicity.Int J Cancer2010 Mar 15Pilzer Ddoi: 10.1002/ijc.24888.
26955804The clinicopathological significance of Mortalin overexpression in invasive ductal carcinoma of breast.J Exp Clin Cancer Res2016 Mar 9Jin Hdoi: 10.1186/s13046-016-0316-0.
28349826Mortalin overexpression predicts poor prognosis in early stage of non-small cell lung cancer.Tumour Biol2017 MarSun Jdoi: 10.1177/1010428317695918.
25012652Identification and functional characterization of nuclear mortalin in human carcinogenesis.J Biol Chem2014 Sep 5Ryu Jdoi: 10.1074/jbc.M114.565929
24050266Molecular interactions of Bcl-2 and Bcl-xL with mortalin: identification and functional characterization.Biosci Rep2013 Oct 16Saxena Ndoi: 10.1042/BSR20130034.
23665506Inhibition of mortalin expression reverses cisplatin resistance and attenuates growth of ovarian cancer cells.Cancer Lett2013 Aug 9Yang Ldoi: 10.1016/j.canlet.2013.05.004
16425258Upregulation of mortalin/mthsp70/Grp75 contributes to human carcinogenesis.Int J Cancer2006 Jun 15Wadhwa R-
23828548Mortalin is a prognostic factor of gastric cancer with normal p53 function.Gastric Cancer2014 AprAndo Kdoi: 10.1007/s10120-013-0279-1
24625977Ubiquitin-like (UBX)-domain-containing protein, UBXN2A, promotes cell death by interfering with the p53-Mortalin interactions in colon cancer cells.Cell Death Dis2014 Mar 13Sane Sdoi: 10.1038/cddis.2014.100.
21496427[RNA Interference targeting GRP75 decreases cisplatin resistance in human lung adenocarcinoma cell].Zhongguo Fei Ai Za Zhi2011 AprShi Sdoi: 10.3779/j.issn.1009-3419.2011.04.01.
23319326Elevated levels of mitochondrial mortalin and cytosolic HSP70 in blood as risk factors in patients with colorectal cancer.Int J Cancer2013 Jul 15Rozenberg Pdoi: 10.1002/ijc.28029
30776464Mortalin is a distinct bio-marker and prognostic factor in serous ovarian carcinoma.Gene2019 May 15Xu Mdoi: 10.1016/j.gene.2019.02.033

Differential Expression

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
BLCAchr5138573846Missense_MutationnovelE49K0.28
BLCAchr5138571050Missense_MutationnovelR107Q0.22
BLCAchr5138566680Missense_MutationNAQ306H0.11
BLCAchr5138567010Missense_MutationnovelF290L0.32
BLCAchr5138560004Nonsense_MutationnovelQ424*0.58
BLCAchr5138556581SilentnovelL611L0.34
BLCAchr5138556551SilentnovelL621L0.07
BLCAchr5138557344Intronnovel0.61
BLCAchr5138567005Missense_MutationnovelR292T0.18
BRCAchr51385558963'UTRnovel0.42
BRCAchr5138561721SilentnovelT347T0.06
BRCAchr5138573848Nonsense_MutationNAS48*0.22
BRCAchr5138556496Missense_MutationNAL640V0.35
BRCAchr5138556982Intronnovel0.29
BRCAchr5138557987Splice_SiteNAX506_splice0.22
BRCAchr5138566636Missense_MutationNAS321L0.27
BRCAchr51385559593'UTRrs5346091240.29
BRCAchr5138566715Frame_Shift_Delrs772570880V296*0.19
CESCchr5138561712SilentnovelQ350Q0.55
CESCchr5138568965Missense_MutationNAQ165H0.11
CESCchr5138556857Nonsense_MutationNAE580*0.26
CESCchr5138567655SilentNAQ201Q0.86
CESCchr5138556470Silentrs148730345F648F0.48
CHOLchr5138557890In_Frame_DelnovelD536_K537del0.1
COADchr5138557465Missense_MutationNAK555N0.2
COADchr5138567715SilentnovelY181Y0.3
COADchr5138559968SilentnovelL436L0.23
COADchr5138567470Missense_MutationNAK234T0.16
COADchr5138559986Missense_MutationnovelG430S0.35
COADchr5138561588Missense_MutationnovelM392V0.4
COADchr5138567030Missense_Mutationrs776644009R284W0.29
COADchr5138575250SilentNAA23A0.47
COADchr5138557363Intronnovel0.11
COADchr51385559593'UTRrs5346091240.31
COADchr5138556108Missense_MutationnovelS657P0.06
COADchr5138561640SilentnovelE374E0.41
COADchr5138561618Nonsense_MutationNAE382*0.12
ESCAchr5138573781In_Frame_InsnovelM70delinsIT0.23
ESCAchr5138559945SilentnovelL443L0.25
GBMchr5138559918SilentnovelG452G0.11
HNSCchr5138571010SilentnovelT120T0.26
HNSCchr5138556988Intronnovel0.57
HNSCchr5138567016Missense_MutationnovelK288N0.23
HNSCchr5138556933Intronnovel0.11
HNSCchr51385753635'UTRnovel0.12
KIRCchr5138566670Nonsense_MutationnovelE310*0.26
KIRCchr5138567712Silentrs751963587L182L0.33
KIRCchr5138575287Missense_MutationNAR11L0.38
KIRCchr5138560078Missense_MutationNAV399A0.25
KIRPchr5138567527Missense_MutationNAN215S0.09
KIRPchr5138569044Frame_Shift_DelnovelN139Mfs*330.43
LGGchr5138559976Missense_MutationnovelT433M0.1
LGGchr5138570991Nonsense_MutationNAR127*0.11
LIHCchr5138560027Missense_MutationnovelA416V0.3
LIHCchr5138557932Missense_MutationNAI524V0.15
LIHCchr5138561612Missense_MutationnovelI384L0.26
LUADchr5138556831SilentnovelI588I0.47
LUADchr5138556916Intronnovel0.14
LUADchr5138561583SilentnovelP393P0.15
LUSCchr5138567026Missense_MutationnovelH285L0.58
LUSCchr5138569017Missense_MutationnovelS148C0.43
LUSCchr5138568922Splice_Regionnovel0.18
LUSCchr5138571001SilentnovelL123L0.12
LUSCchr5138568952Missense_Mutationrs760801530V170M0.23
LUSCchr5138556920Intronnovel0.21
LUSCchr5138571120Missense_MutationNAA84S0.38
LUSCchr5138574157Intronnovel0.54
LUSCchr5138558640SilentnovelA476A0.44
LUSCchr5138571015Missense_MutationNAA119T0.08
LUSCchr5138571063Missense_MutationnovelM103V0.07
LUSCchr5138556920Intronnovel0.82
OVchr5138571088SilentnovelT94T0.06
OVchr51385560093'UTRnovel0.2
OVchr5138560056SilentnovelA406A0.42
OVchr51385559593'UTRrs5346091240.31
PAADchr5138571046Missense_MutationnovelQ108H0.05
PRADchr5138556519Frame_Shift_DelnovelN632Yfs*20.48
READchr5138557409Missense_Mutationrs372075340R574Q0.35
READchr5138559869Missense_MutationnovelS469G0.25
READchr5138571046Silentrs754498058Q108Q0.53
READchr5138556974Intronnovel0.4
SKCMchr5138561042Intronrs5554327340.3
SKCMchr5138571109SilentNAT87T0.41
SKCMchr5138571001SilentNAL123L0.41
STADchr5138566666Missense_MutationNAA311G0.06
STADchr5138557974Missense_Mutationrs752447855P510S0.23
STADchr5138556470Silentrs148730345F648F0.32
STADchr5138567658Silentrs762248139S200S0.35
STADchr5138558628Silentrs149852902T480T0.1
STADchr5138556458SilentNAY652Y0.29
STADchr5138559887Missense_MutationNAT463A0.26
STADchr51385559643'UTRnovel0.09
THYMchr5138556932Intronnovel0.44
UCECchr5138567456Missense_Mutationrs758625540V239F0.27
UCECchr5138570981Missense_MutationNAD130G0.27
UCECchr5138567078Missense_MutationNAN268H0.22
UCECchr5138556799Missense_MutationnovelF599C0.33
UCECchr5138556824Missense_Mutationrs761237709D591N0.1
UCECchr5138557042Intronnovel0.23
UCECchr5138573837Missense_MutationnovelK52E0.34
UCECchr5138566719Splice_SitenovelX294_splice0.07
UCECchr5138556863Nonsense_Mutationrs757156840R578*0.43
UCECchr5138557261Intronnovel0.3
UCECchr5138561755Missense_MutationnovelS336Y0.17
UCECchr5138559888SilentnovelT462T0.08
UCECchr5138561760Missense_MutationnovelM334I0.21
UCECchr5138556774Missense_MutationnovelE607D0.05
UCECchr5138557271IntronNA0.13
UCECchr5138557409Missense_Mutationrs372075340R574Q0.42
UCECchr5138573761Splice_SitenovelX76_splice0.44
UCECchr5138575251Missense_MutationnovelA23V0.39
UCECchr5138570990Missense_Mutationrs375941962R127Q0.61
UCECchr51385558323'UTRnovel0.42
UCECchr5138556824Missense_Mutationrs761237709D591N0.5
UCECchr5138574067Splice_SiteNAX47_splice0.33
UCECchr5138559912SilentnovelF454F0.39
UCECchr51385558713'UTRnovel0.29
UCECchr5138557378Intronnovel0.18
UCECchr51385753575'UTRrs7581620460.42
UCECchr5138571056Missense_MutationnovelA105V0.48
UCECchr5138557262Intronnovel0.38
UCECchr5138556566SilentNAS616S0.3
UCECchr5138557463Missense_MutationnovelD556V0.44
UCECchr5138561064Intronnovel0.33
UCECchr5138567560Missense_MutationNAA204D0.21
UCECchr5138557432Missense_MutationNAE566D0.44
UCECchr5138567667Missense_MutationNAF197L0.33
UCECchr5138567080Missense_MutationnovelT267I0.3
UCECchr5138566672Missense_MutationnovelR309Q0.4
UCECchr5138557084Intronnovel0.36
UCSchr51385560263'UTRnovel0.38

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
KIRPAMP0.10760.069756
KIRPDEL0.03820.11554
LAMLDEL0.0891.2971e-07
LUSCDEL0.61880.002071
MESODEL0.12640.20184
PRADAMP0.03050.16448
SKCMDEL0.29162.2081e-08
THCAAMP0.03610.075436
THCADEL00.23456

Survival Analysis
CancerP-value Q-value
THYM0.035

Kaplan-Meier Survival Analysis

KIRC0.0028

Kaplan-Meier Survival Analysis

MESO0.047

Kaplan-Meier Survival Analysis

ACC0.0025

Kaplan-Meier Survival Analysis

UCS0.027

Kaplan-Meier Survival Analysis

LUSC0.028

Kaplan-Meier Survival Analysis

BRCA0.00042

Kaplan-Meier Survival Analysis

COAD0.017

Kaplan-Meier Survival Analysis

BLCA0.013

Kaplan-Meier Survival Analysis

READ0.022

Kaplan-Meier Survival Analysis

KICH0.023

Kaplan-Meier Survival Analysis

UCEC0.036

Kaplan-Meier Survival Analysis

LUAD0.00072

Kaplan-Meier Survival Analysis

UVM0.0078

Kaplan-Meier Survival Analysis

Drugs

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Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBPome
  • Expression
  • Transcripts
  • Gene Model
  • Pathways
  • Phenotypes
  • PPI
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000113013 (Gene tree)
Gene ID
3313
Gene Symbol
HSPA9
Alias
GRP75|PBP74|mot-2|mthsp75|HSPA9B
Full Name
heat shock protein family A (Hsp70) member 9
Gene Type
protein_coding
Species
Homo_sapiens
Status
putative
Strand
Minus strand
Length
21,969 bases
Position
chr5:138,553,756-138,575,724
Accession
5244
RBP type
non-canonical RBP
Summary
This gene encodes a member of the heat shock protein 70 gene family. The encoded protein is primarily localized to the mitochondria but is also found in the endoplasmic reticulum, plasma membrane and cytoplasmic vesicles. This protein is a heat-shock cognate protein. This protein plays a role in cell proliferation, stress response and maintenance of the mitochondria. A pseudogene of this gene is found on chromosome 2.[provided by RefSeq, May 2010]
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
22681889The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts4SURIC & HEK2932012 MayBaltz AGDOI: 10.1016/j.molcel.2012.05.021
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & HEK2932019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & HEK2932018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
22658674Insights into RNA biology from an atlas of mammalian mRNA-binding proteinsRIC & Hela2012 May 31Castello ADOI: 10.1016/j.cell.2012.04.031
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & Hela2018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & MCF10A2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & MCF72018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & U2OS2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
27453046Comprehensive Identification of RNA-Binding Domains in Human CellsRIC & Hela2016 Aug 18Castello ADOI: 10.1016/j.molcel.2016.06.029
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000524109HSPA9-2131175--- (aa)--
ENST00000504902HSPA9-204887-ENSP00000421311100 (aa)-H0Y8K0
ENST00000649692HSPA9-2162725--- (aa)--
ENST00000507115HSPA9-208663-ENSP0000042375942 (aa)-D6RCD7
ENST00000508003HSPA9-210582--- (aa)--
ENST00000649578HSPA9-2154319-ENSP00000497906180 (aa)--
ENST00000649126HSPA9-2144727-ENSP00000496940679 (aa)-UPI000012BA4E
ENST00000506477HSPA9-206664--- (aa)--
ENST00000501917HSPA9-202285-ENSP0000049797443 (aa)--
ENST00000523929HSPA9-212780-ENSP00000429475163 (aa)-H0YBG6
ENST00000507886HSPA9-209551-ENSP0000042309862 (aa)-D6RA73
ENST00000505110HSPA9-205518-ENSP0000042094438 (aa)-D6RDH7
ENST00000297185HSPA9-2012825-ENSP00000297185679 (aa)-P38646
ENST00000512328HSPA9-211482-ENSP00000421892102 (aa)-H0Y8S0
ENST00000504810HSPA9-203584-ENSP0000042559895 (aa)-D6RJI2
ENST00000507097HSPA9-2071796--- (aa)--
Gene Model
Click here to download ENSG00000113013's gene model file
Pathways
Pathway IDPathway NameSource
hsa03018RNA degradationKEGG
hsa05152TuberculosisKEGG
Phenotypes
ensgIDTraitpValuePubmed ID
ENSG00000113013Platelet Function Tests1.3345900E-005-
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000113013's network

* RBP PPI network refers to all genes directly bind to RBP
Orthologs identified by RBPome
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000113013HSPA910082.258WBGene00002010hsp-69776.682Caenorhabditis_elegans
ENSG00000113013HSPA910090.323FBgn0001220Hsc70-59576.677Drosophila_melanogaster
ENSG00000113013HSPA9100100.000ENSMUSG00000024359Hspa910098.380Mus_musculus
ENSG00000113013HSPA99877.049YJR045CSSC19665.773Saccharomyces_cerevisiae
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0003723RNA binding22658674.22681889.HDAFunction
GO:0005515protein binding10411904.15520177.15657067.17184779.20029029.20153329.20195357.20668094.22340593.22726440.23541579.24189400.24606901.25416956.26702583.28380382.IPIFunction
GO:0005524ATP binding21873635.IBAFunction
GO:0005730nucleolus-IEAComponent
GO:0005737cytoplasm21873635.IBAComponent
GO:0005739mitochondrion21873635.IBAComponent
GO:0005739mitochondrion7896880.26702583.IDAComponent
GO:0005739mitochondrion16130169.TASComponent
GO:0005759mitochondrial matrix-TASComponent
GO:0005925focal adhesion21423176.HDAComponent
GO:0006986response to unfolded protein21873635.IBAProcess
GO:0016226iron-sulfur cluster assembly26702583.IMPProcess
GO:0016887ATPase activity21873635.IBAFunction
GO:0030218erythrocyte differentiation21123823.IMPProcess
GO:0031072heat shock protein binding21873635.IBAFunction
GO:0031625ubiquitin protein ligase binding19725078.21753002.IPIFunction
GO:0034605cellular response to heat21873635.IBAProcess
GO:0034620cellular response to unfolded protein21873635.IBAProcess
GO:0035722interleukin-12-mediated signaling pathway-TASProcess
GO:0042026protein refolding21873635.IBAProcess
GO:0042623ATPase activity, coupled21873635.IBAFunction
GO:0042645mitochondrial nucleoid18063578.IDAComponent
GO:0043066negative regulation of apoptotic process16130169.TASProcess
GO:0044183protein binding involved in protein folding21873635.IBAFunction
GO:0045646regulation of erythrocyte differentiation26702583.IMPProcess
GO:0045647negative regulation of erythrocyte differentiation21123823.IMPProcess
GO:0051082unfolded protein binding21873635.IBAFunction
GO:0051082unfolded protein binding16130169.TASFunction
GO:0051085chaperone cofactor-dependent protein refolding21873635.IBAProcess
GO:0051787misfolded protein binding21873635.IBAFunction
GO:0070062extracellular exosome20458337.HDAComponent
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