EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
19818763	Minichromosome maintenance protein 3 is a candidate proliferation marker in papillary thyroid carcinoma.	Exp Mol Pathol	2010 Feb	Lee YS	doi: 10.1016/j.yexmp.2009.09.015
24324072	Comparison of minichromosome maintenance proteins (MCM-3, MCM-7) and metallothioneins (MT-I/II, MT-III) expression in relation to clinicopathological data in ovarian cancer.	Anticancer Res	2013 Dec	Kobierzycki C	-
15671553	Minichromosome maintenance protein 3 elicits a cancer-restricted immune response in patients with brain malignancies and is a strong independent predictor of survival in patients with anaplastic astrocytoma.	Clin Cancer Res	2005 Jan 1	Sling A	-
28424404	Upregulation of minichromosome maintenance complex component 3 during epithelial-to-mesenchymal transition in human prostate cancer.	Oncotarget	2017 Jun 13	Stewart PA	doi: 10.18632/oncotarget.16835.

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
ACC	chr6	52276468	Missense_Mutation	rs144158830	R392C	0.44
BLCA	chr6	52282690	Silent	novel	L121L	0.43
BLCA	chr6	52272415	Silent	rs574315963	Y571Y	0.26
BLCA	chr6	52264762	Silent	novel	L751L	0.35
BLCA	chr6	52278812	Missense_Mutation	novel	K270T	0.09
BRCA	chr6	52273318	Missense_Mutation	NA	D530H	0.15
BRCA	chr6	52264556	3'UTR	novel		0.11
BRCA	chr6	52273272	Missense_Mutation	novel	Y545S	0.05
BRCA	chr6	52282120	Silent	NA	K152K	0.19
BRCA	chr6	52264446	3'UTR	novel		0.18
BRCA	chr6	52264504	3'UTR	novel		0.32
BRCA	chr6	52284758	5'Flank	novel		0.39
BRCA	chr6	52264723	Silent	NA	G764G	0.26
COAD	chr6	52264261	3'UTR	novel		0.18
COAD	chr6	52264409	3'UTR	novel		0.18
COAD	chr6	52264596	Missense_Mutation	NA	L807I	0.21
COAD	chr6	52273745	Missense_Mutation	NA	D516N	0.18
COAD	chr6	52264412	3'UTR	novel		0.2
COAD	chr6	52264726	Silent	NA	I763I	0.39
ESCA	chr6	52267876	Missense_Mutation	novel	Q687H	0.25
ESCA	chr6	52277654	Frame_Shift_Del	novel	*L299Qfs25**	0.23
GBM	chr6	52272341	Missense_Mutation	novel	R596H	0.08
GBM	chr6	52277142	Nonsense_Mutation	rs769266579	R364*	0.38
GBM	chr6	52264785	Splice_Region	novel	L744L	0.22
GBM	chr6	52266668	Missense_Mutation	novel	D701Y	0.57
GBM	chr6	52267918	Missense_Mutation	novel	E673D	0.28
GBM	chr6	52267941	Nonsense_Mutation	novel	K666*	0.08
GBM	chr6	52267920	Missense_Mutation	novel	E673Q	0.36
GBM	chr6	52282712	Missense_Mutation	NA	R114L	0.06
GBM	chr6	52273298	Missense_Mutation	novel	Q536H	0.04
HNSC	chr6	52264621	Silent	novel	V798V	0.07
HNSC	chr6	52278847	Silent	novel	T258T	0.06
HNSC	chr6	52264597	Missense_Mutation	novel	F806L	0.25
HNSC	chr6	52269084	Splice_Site	novel	X656_splice	0.31
HNSC	chr6	52277131	Frame_Shift_Del	novel	*T368Pfs11**	0.4
HNSC	chr6	52273798	Nonsense_Mutation	novel	S498*	0.25
HNSC	chr6	52277140	Silent	novel	R364R	0.17
KIRC	chr6	52264438	3'UTR	novel		0.74
KIRC	chr6	52264756	Missense_Mutation	novel	D753E	0.64
KIRP	chr6	52276475	Splice_Region	novel	G389G	0.82
KIRP	chr6	52277175	Missense_Mutation	NA	Q353E	0.31
LAML	chr6	52267880	Missense_Mutation	novel	E686G	0.06
LAML	chr6	52266666	Silent	novel	D701D	0.02
LGG	chr6	52272318	Missense_Mutation	novel	S604G	0.15
LGG	chr6	52273912	Missense_Mutation	novel	D460A	0.3
LIHC	chr6	52264588	Nonstop_Mutation	NA	809Cext38	0.51
LIHC	chr6	52267970	Splice_Site	novel	X657_splice	0.39
LIHC	chr6	52277128	In_Frame_Del	novel	R364_T368del	0.28
LUAD	chr6	52273755	Missense_Mutation	novel	E512D	0.15
LUAD	chr6	52279557	Missense_Mutation	novel	V192F	0.08
LUAD	chr6	52276454	Silent	novel	G396G	0.18
LUAD	chr6	52276455	Missense_Mutation	novel	G396V	0.18
LUAD	chr6	52276467	Missense_Mutation	novel	R392L	0.2
LUAD	chr6	52277082	Missense_Mutation	novel	T384A	0.24
LUAD	chr6	52273297	Missense_Mutation	novel	E537Q	0.42
LUAD	chr6	52267937	Missense_Mutation	novel	R667L	0.72
LUAD	chr6	52282795	Silent	novel	S86S	0.14
LUAD	chr6	52278789	Missense_Mutation	rs775943986	A278T	0.66
LUAD	chr6	52284670	Missense_Mutation	NA	A2V	0.38
LUAD	chr6	52269175	Missense_Mutation	novel	A627S	0.15
LUSC	chr6	52282791	Missense_Mutation	novel	D88H	0.24
LUSC	chr6	52278804	Nonsense_Mutation	rs772735200	Q273*	0.38
LUSC	chr6	52266616	Missense_Mutation	rs757939863	P718L	0.09
MESO	chr6	52264579	3'UTR	rs537207438		0.41
OV	chr6	52283322	Missense_Mutation	novel	R55S	0.05
OV	chr6	52269180	Missense_Mutation	novel	A625V	0.05
OV	chr6	52264414	3'UTR	novel		0.74
OV	chr6	52278850	Splice_Region	NA	R257R	0.41
OV	chr6	52267880	Missense_Mutation	novel	E686G	0.12
OV	chr6	52264778	Missense_Mutation	novel	A746G	0.05
OV	chr6	52273765	Missense_Mutation	NA	A509V	0.43
OV	chr6	52273272	In_Frame_Del	novel	Q543_Y545delinsH	0.03
PAAD	chr6	52282134	Missense_Mutation	novel	C148R	0.13
PAAD	chr6	52264469	3'UTR	novel		0.17
PAAD	chr6	52267888	Missense_Mutation	novel	E683D	0.09
PAAD	chr6	52276320	Missense_Mutation	rs748488798	R441Q	0.06
PAAD	chr6	52282774	Missense_Mutation	NA	K93N	0.17
PAAD	chr6	52283378	Missense_Mutation	novel	V36A	0.16
PRAD	chr6	52272321	Missense_Mutation	NA	M603L	0.05
PRAD	chr6	52283380	Silent	NA	K35K	0.06
PRAD	chr6	52276470	Missense_Mutation	rs146513110	R391H	0.43
PRAD	chr6	52277147	Missense_Mutation	novel	A362V	0.46
PRAD	chr6	52283321	Missense_Mutation	rs750663816	R55H	0.43
READ	chr6	52283321	Missense_Mutation	rs750663816	R55H	0.24
READ	chr6	52276414	Nonsense_Mutation	novel	E410*	0.44
READ	chr6	52282164	Missense_Mutation	rs371347878	R138C	0.44
READ	chr6	52282148	Missense_Mutation	rs765811660	R143H	0.13
SARC	chr6	52277592	Missense_Mutation	novel	E326K	0.26
SKCM	chr6	52276328	Silent	novel	I438I	0.58
SKCM	chr6	52264603	Silent	novel	I804I	0.36
SKCM	chr6	52279491	Missense_Mutation	NA	P214S	0.1
SKCM	chr6	52279588	Missense_Mutation	novel	N181K	0.45
SKCM	chr6	52273241	Silent	novel	T555T	0.06
SKCM	chr6	52276387	Missense_Mutation	rs766478737	R419C	0.33
SKCM	chr6	52279465	Frame_Shift_Del	novel	*D222Efs39**	0.26
SKCM	chr6	52276387	Missense_Mutation	rs766478737	R419C	0.13
SKCM	chr6	52278746	Missense_Mutation	NA	S292F	0.5
SKCM	chr6	52264534	3'UTR	novel		0.19
SKCM	chr6	52277562	Missense_Mutation	novel	R336C	0.17
SKCM	chr6	52277134	Silent	NA	I366I	0.37
SKCM	chr6	52272412	Silent	novel	I572I	0.24
SKCM	chr6	52264599	Missense_Mutation	NA	F806L	0.31
SKCM	chr6	52277189	Missense_Mutation	novel	S348F	0.38
SKCM	chr6	52266650	Missense_Mutation	NA	P707S	0.19
SKCM	chr6	52277562	Missense_Mutation	novel	R336C	0.29
SKCM	chr6	52273787	Missense_Mutation	NA	L502F	0.75
SKCM	chr6	52279398	Missense_Mutation	NA	P245S	0.42
SKCM	chr6	52266639	Silent	novel	F710F	0.26
STAD	chr6	52282771	Missense_Mutation	NA	Q94H	0.31
STAD	chr6	52267947	Missense_Mutation	rs143308289	R664C	0.15
STAD	chr6	52272306	Missense_Mutation	rs754057696	A608T	0.23
STAD	chr6	52269168	Missense_Mutation	rs772883621	A629V	0.25
STAD	chr6	52282755	Missense_Mutation	rs146219216	V100I	0.25
STAD	chr6	52277614	Silent	novel	L318L	0.2
STAD	chr6	52279487	Missense_Mutation	rs377411679	R215H	0.21
THCA	chr6	52264726	Silent	rs111523955	I763I	0.36
UCEC	chr6	52277597	Missense_Mutation	NA	G324E	0.55
UCEC	chr6	52264372	3'UTR	novel		0.11
UCEC	chr6	52269207	Missense_Mutation	NA	R616Q	0.29
UCEC	chr6	52267937	Missense_Mutation	NA	R667Q	0.38
UCEC	chr6	52264637	Missense_Mutation	novel	Q793R	0.31
UCEC	chr6	52266654	Silent	rs61752698	Y705Y	0.29
UCEC	chr6	52266685	Missense_Mutation	novel	R695H	0.42
UCEC	chr6	52283347	Silent	novel	R46R	0.38
UCEC	chr6	52276470	Missense_Mutation	rs146513110	R391H	0.51
UCEC	chr6	52282661	Missense_Mutation	novel	V131A	0.09
UCEC	chr6	52279501	Silent	rs112388885	A210A	0.26
UCEC	chr6	52266122	Missense_Mutation	novel	D727E	0.48
UCEC	chr6	52267873	Missense_Mutation	NA	K688N	0.24
UCEC	chr6	52278848	Missense_Mutation	novel	T258N	0.05
UCEC	chr6	52282691	Missense_Mutation	novel	L121H	0.49
UCEC	chr6	52267937	Missense_Mutation	NA	R667Q	0.11
UCEC	chr6	52273835	Silent	NA	L486L	0.32
UCEC	chr6	52278811	Missense_Mutation	NA	K270N	0.51
UCEC	chr6	52282774	Missense_Mutation	NA	K93N	0.46
UCEC	chr6	52277161	Silent	rs770923814	Y357Y	0.35
UCEC	chr6	52276336	Missense_Mutation	novel	A436T	0.41
UCEC	chr6	52273859	Nonsense_Mutation	novel	R478*	0.28
UCEC	chr6	52279476	Missense_Mutation	rs201702015	V219I	0.36
UCEC	chr6	52282163	Missense_Mutation	rs752149151	R138H	0.46
UCEC	chr6	52282768	Silent	novel	Y95Y	0.27
UCEC	chr6	52266127	Missense_Mutation	NA	A726T	0.07
UCEC	chr6	52266668	Missense_Mutation	novel	D701N	0.34
UCEC	chr6	52283356	Silent	novel	N43N	0.22
UCEC	chr6	52282106	Missense_Mutation	rs778687751	R157Q	0.47
UCEC	chr6	52269167	Silent	novel	A629A	0.35
UCEC	chr6	52276403	Missense_Mutation	novel	K413N	0.46
UCEC	chr6	52264587	3'UTR	novel		0.22
UCEC	chr6	52276386	Missense_Mutation	rs758287245	R419H	0.14
UCEC	chr6	52282075	Silent	novel	A167A	0.11
UCEC	chr6	52279445	Missense_Mutation	novel	A229V	0.38
UCEC	chr6	52273894	Missense_Mutation	novel	M466T	0.38
UCEC	chr6	52282798	Silent	novel	A85A	0.14
UCEC	chr6	52264470	3'UTR	novel		0.5
UCEC	chr6	52266653	Missense_Mutation	NA	D706N	0.25
UCEC	chr6	52264383	3'UTR	novel		0.4
UCEC	chr6	52283346	Silent	novel	L47L	0.18
UCEC	chr6	52282149	Missense_Mutation	novel	R143S	0.45
UCEC	chr6	52273819	Missense_Mutation	NA	P491H	0.37
UCEC	chr6	52277141	Missense_Mutation	rs150139384	R364Q	0.4
UCEC	chr6	52279436	Missense_Mutation	novel	G232D	0.51
UCEC	chr6	52284740	5'UTR	novel		0.48
UCS	chr6	52278807	Missense_Mutation	novel	A272S	0.07
UCS	chr6	52273902	Silent	novel	K463K	0.3

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
KIRP	DEL	0.0833	0.11427

Survival Analysis

Cancer	P-value	Q-value
THYM	0.0019	Kaplan-Meier Survival Analysis
STAD	0.012	Kaplan-Meier Survival Analysis
SARC	0.00049	Kaplan-Meier Survival Analysis
MESO	0.014	Kaplan-Meier Survival Analysis
ACC	0.00016	Kaplan-Meier Survival Analysis
KIRP	0.012	Kaplan-Meier Survival Analysis
PCPG	0.037	Kaplan-Meier Survival Analysis
BLCA	0.034	Kaplan-Meier Survival Analysis
CESC	0.0015	Kaplan-Meier Survival Analysis
READ	0.028	Kaplan-Meier Survival Analysis
LAML	0.018	Kaplan-Meier Survival Analysis
KICH	0.00059	Kaplan-Meier Survival Analysis
UCEC	0.023	Kaplan-Meier Survival Analysis
LIHC	0.00018	Kaplan-Meier Survival Analysis
DLBC	0.035	Kaplan-Meier Survival Analysis
LGG	0.00011	Kaplan-Meier Survival Analysis
THCA	0.0084	Kaplan-Meier Survival Analysis
OV	0.0045	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000112118 (Gene tree)
Gene ID: 4172
Gene Symbol: MCM3
Alias: N
Full Name: minichromosome maintenance complex component 3
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 20,873 bases
Position: chr6:52,264,009-52,284,881
Accession: 6945
RBP type: non-canonical RBP
Summary: The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein is a subunit of the protein complex that consists of MCM2-7. It has been shown to interact directly with MCM5/CDC46. This protein also interacts with and is acetylated by MCM3AP, a chromatin-associated acetyltransferase. The acetylation of this protein inhibits the initiation of DNA replication and cell cycle progression. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2018]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30352994	Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome capture	RIC & Jurkat	2018 Oct 23	Perez-Perri JI	DOI:10.1038/s41467-018-06557-8

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
12885157	Involvement of GANP in B cell activation in T cell-dependent antigen response.	Dev Immunol	2002 Sep	Sakaguchi N	-

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000421471	MCM3-203	1030	-	ENSP00000407651	328 (aa)	-	Q7Z6P5
ENST00000476448	MCM3-204	982	-	-	- (aa)	-	-
ENST00000596983	MCM3-206	559	-	ENSP00000470057	77 (aa)	-	M0QYS9
ENST00000596288	MCM3-205	3169	-	ENSP00000472940	853 (aa)	-	P25205
ENST00000419835	MCM3-202	2523	-	ENSP00000388647	818 (aa)	-	J3KQ69
ENST00000616552	MCM3-207	3208	-	ENSP00000480987	853 (aa)	-	P25205
ENST00000229854	MCM3-201	3083	-	ENSP00000229854	808 (aa)	-	P25205

Gene Model

Click here to download ENSG00000112118's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa03030	DNA replication	KEGG
hsa04110	Cell cycle	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000112118	Alanine Transaminase	7.551e-005	-
ENSG00000112118	Alanine Transaminase	7.551e-005	-
ENSG00000112118	Child Development Disorders, Pervasive	1.1476000E-005	-
ENSG00000112118	Child Development Disorders, Pervasive	4.0056000E-006	-
ENSG00000112118	Carcinoma, squamous cell of head and neck	3E-6	27670397
ENSG00000112118	Pain	3E-6	27670397

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000112118	rs3789775	6	52270696	A	Pre-treatment pain in head and neck squamous cell carcinoma	27670397	[1.40-2.30]	1.8	EFO_0003843\|EFO_0000181

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000112118's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000112118	MCM3	79	32.985	WBGene00003157	mcm-5	84	33.084	Caenorhabditis_elegans
ENSG00000112118	MCM3	85	30.606	FBgn0017577	Mcm5	85	31.390	Drosophila_melanogaster
ENSG00000112118	MCM3	78	33.236	FBgn0020633	Mcm7	86	33.382	Drosophila_melanogaster
ENSG00000112118	MCM3	68	37.324	ENSG00000166508	MCM7	76	40.257	Homo_sapiens
ENSG00000112118	MCM3	79	31.060	ENSG00000076003	MCM6	79	30.835	Homo_sapiens
ENSG00000112118	MCM3	82	31.878	ENSG00000100297	MCM5	81	32.767	Homo_sapiens
ENSG00000112118	MCM3	100	92.638	ENSMUSG00000041859	Mcm3	100	92.638	Mus_musculus
ENSG00000112118	MCM3	71	37.005	ENSMUSG00000029730	Mcm7	70	37.367	Mus_musculus
ENSG00000112118	MCM3	81	49.858	YEL032W		71	49.858	Saccharomyces_cerevisiae
ENSG00000112118	MCM3	80	31.171	YLR274W	MCM5	86	31.786	Saccharomyces_cerevisiae
ENSG00000112118	MCM3	67	32.792	YGL201C		55	33.061	Saccharomyces_cerevisiae

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000082	G1/S transition of mitotic cell cycle	-	TAS	Process
GO:0000784	nuclear chromosome, telomeric region	19135898.	HDA	Component
GO:0003677	DNA binding	-	IEA	Function
GO:0004386	helicase activity	-	IEA	Function
GO:0005515	protein binding	12364596.15232106.16899510.17296731.19150984.19862764.22540012.24299456.25036637.26167883.26496610.29395061.	IPI	Function
GO:0005524	ATP binding	-	IEA	Function
GO:0005634	nucleus	20531406.21383955.	IDA	Component
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005658	alpha DNA polymerase:primase complex	1549468.	TAS	Component
GO:0005730	nucleolus	21383955.	IDA	Component
GO:0005813	centrosome	-	IDA	Component
GO:0006260	DNA replication	-	TAS	Process
GO:0006270	DNA replication initiation	-	IEA	Process
GO:0016020	membrane	19946888.	HDA	Component
GO:0042555	MCM complex	17296731.	IDA	Component
GO:0048471	perinuclear region of cytoplasm	20531406.	IDA	Component

EuRBPDB

Note: to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.