EuRBPDB

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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
19818763Minichromosome maintenance protein 3 is a candidate proliferation marker in papillary thyroid carcinoma.Exp Mol Pathol2010 FebLee YSdoi: 10.1016/j.yexmp.2009.09.015
24324072Comparison of minichromosome maintenance proteins (MCM-3, MCM-7) and metallothioneins (MT-I/II, MT-III) expression in relation to clinicopathological data in ovarian cancer.Anticancer Res2013 DecKobierzycki C-
15671553Minichromosome maintenance protein 3 elicits a cancer-restricted immune response in patients with brain malignancies and is a strong independent predictor of survival in patients with anaplastic astrocytoma.Clin Cancer Res2005 Jan 1Sling A-
28424404Upregulation of minichromosome maintenance complex component 3 during epithelial-to-mesenchymal transition in human prostate cancer.Oncotarget2017 Jun 13Stewart PAdoi: 10.18632/oncotarget.16835.

Differential Expression

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
ACCchr652276468Missense_Mutationrs144158830R392C0.44
BLCAchr652282690SilentnovelL121L0.43
BLCAchr652272415Silentrs574315963Y571Y0.26
BLCAchr652264762SilentnovelL751L0.35
BLCAchr652278812Missense_MutationnovelK270T0.09
BRCAchr652273318Missense_MutationNAD530H0.15
BRCAchr6522645563'UTRnovel0.11
BRCAchr652273272Missense_MutationnovelY545S0.05
BRCAchr652282120SilentNAK152K0.19
BRCAchr6522644463'UTRnovel0.18
BRCAchr6522645043'UTRnovel0.32
BRCAchr6522847585'Flanknovel0.39
BRCAchr652264723SilentNAG764G0.26
COADchr6522642613'UTRnovel0.18
COADchr6522644093'UTRnovel0.18
COADchr652264596Missense_MutationNAL807I0.21
COADchr652273745Missense_MutationNAD516N0.18
COADchr6522644123'UTRnovel0.2
COADchr652264726SilentNAI763I0.39
ESCAchr652267876Missense_MutationnovelQ687H0.25
ESCAchr652277654Frame_Shift_DelnovelL299Qfs*250.23
GBMchr652272341Missense_MutationnovelR596H0.08
GBMchr652277142Nonsense_Mutationrs769266579R364*0.38
GBMchr652264785Splice_RegionnovelL744L0.22
GBMchr652266668Missense_MutationnovelD701Y0.57
GBMchr652267918Missense_MutationnovelE673D0.28
GBMchr652267941Nonsense_MutationnovelK666*0.08
GBMchr652267920Missense_MutationnovelE673Q0.36
GBMchr652282712Missense_MutationNAR114L0.06
GBMchr652273298Missense_MutationnovelQ536H0.04
HNSCchr652264621SilentnovelV798V0.07
HNSCchr652278847SilentnovelT258T0.06
HNSCchr652264597Missense_MutationnovelF806L0.25
HNSCchr652269084Splice_SitenovelX656_splice0.31
HNSCchr652277131Frame_Shift_DelnovelT368Pfs*110.4
HNSCchr652273798Nonsense_MutationnovelS498*0.25
HNSCchr652277140SilentnovelR364R0.17
KIRCchr6522644383'UTRnovel0.74
KIRCchr652264756Missense_MutationnovelD753E0.64
KIRPchr652276475Splice_RegionnovelG389G0.82
KIRPchr652277175Missense_MutationNAQ353E0.31
LAMLchr652267880Missense_MutationnovelE686G0.06
LAMLchr652266666SilentnovelD701D0.02
LGGchr652272318Missense_MutationnovelS604G0.15
LGGchr652273912Missense_MutationnovelD460A0.3
LIHCchr652264588Nonstop_MutationNA*809Cext*380.51
LIHCchr652267970Splice_SitenovelX657_splice0.39
LIHCchr652277128In_Frame_DelnovelR364_T368del0.28
LUADchr652273755Missense_MutationnovelE512D0.15
LUADchr652279557Missense_MutationnovelV192F0.08
LUADchr652276454SilentnovelG396G0.18
LUADchr652276455Missense_MutationnovelG396V0.18
LUADchr652276467Missense_MutationnovelR392L0.2
LUADchr652277082Missense_MutationnovelT384A0.24
LUADchr652273297Missense_MutationnovelE537Q0.42
LUADchr652267937Missense_MutationnovelR667L0.72
LUADchr652282795SilentnovelS86S0.14
LUADchr652278789Missense_Mutationrs775943986A278T0.66
LUADchr652284670Missense_MutationNAA2V0.38
LUADchr652269175Missense_MutationnovelA627S0.15
LUSCchr652282791Missense_MutationnovelD88H0.24
LUSCchr652278804Nonsense_Mutationrs772735200Q273*0.38
LUSCchr652266616Missense_Mutationrs757939863P718L0.09
MESOchr6522645793'UTRrs5372074380.41
OVchr652283322Missense_MutationnovelR55S0.05
OVchr652269180Missense_MutationnovelA625V0.05
OVchr6522644143'UTRnovel0.74
OVchr652278850Splice_RegionNAR257R0.41
OVchr652267880Missense_MutationnovelE686G0.12
OVchr652264778Missense_MutationnovelA746G0.05
OVchr652273765Missense_MutationNAA509V0.43
OVchr652273272In_Frame_DelnovelQ543_Y545delinsH0.03
PAADchr652282134Missense_MutationnovelC148R0.13
PAADchr6522644693'UTRnovel0.17
PAADchr652267888Missense_MutationnovelE683D0.09
PAADchr652276320Missense_Mutationrs748488798R441Q0.06
PAADchr652282774Missense_MutationNAK93N0.17
PAADchr652283378Missense_MutationnovelV36A0.16
PRADchr652272321Missense_MutationNAM603L0.05
PRADchr652283380SilentNAK35K0.06
PRADchr652276470Missense_Mutationrs146513110R391H0.43
PRADchr652277147Missense_MutationnovelA362V0.46
PRADchr652283321Missense_Mutationrs750663816R55H0.43
READchr652283321Missense_Mutationrs750663816R55H0.24
READchr652276414Nonsense_MutationnovelE410*0.44
READchr652282164Missense_Mutationrs371347878R138C0.44
READchr652282148Missense_Mutationrs765811660R143H0.13
SARCchr652277592Missense_MutationnovelE326K0.26
SKCMchr652276328SilentnovelI438I0.58
SKCMchr652264603SilentnovelI804I0.36
SKCMchr652279491Missense_MutationNAP214S0.1
SKCMchr652279588Missense_MutationnovelN181K0.45
SKCMchr652273241SilentnovelT555T0.06
SKCMchr652276387Missense_Mutationrs766478737R419C0.33
SKCMchr652279465Frame_Shift_DelnovelD222Efs*390.26
SKCMchr652276387Missense_Mutationrs766478737R419C0.13
SKCMchr652278746Missense_MutationNAS292F0.5
SKCMchr6522645343'UTRnovel0.19
SKCMchr652277562Missense_MutationnovelR336C0.17
SKCMchr652277134SilentNAI366I0.37
SKCMchr652272412SilentnovelI572I0.24
SKCMchr652264599Missense_MutationNAF806L0.31
SKCMchr652277189Missense_MutationnovelS348F0.38
SKCMchr652266650Missense_MutationNAP707S0.19
SKCMchr652277562Missense_MutationnovelR336C0.29
SKCMchr652273787Missense_MutationNAL502F0.75
SKCMchr652279398Missense_MutationNAP245S0.42
SKCMchr652266639SilentnovelF710F0.26
STADchr652282771Missense_MutationNAQ94H0.31
STADchr652267947Missense_Mutationrs143308289R664C0.15
STADchr652272306Missense_Mutationrs754057696A608T0.23
STADchr652269168Missense_Mutationrs772883621A629V0.25
STADchr652282755Missense_Mutationrs146219216V100I0.25
STADchr652277614SilentnovelL318L0.2
STADchr652279487Missense_Mutationrs377411679R215H0.21
THCAchr652264726Silentrs111523955I763I0.36
UCECchr652277597Missense_MutationNAG324E0.55
UCECchr6522643723'UTRnovel0.11
UCECchr652269207Missense_MutationNAR616Q0.29
UCECchr652267937Missense_MutationNAR667Q0.38
UCECchr652264637Missense_MutationnovelQ793R0.31
UCECchr652266654Silentrs61752698Y705Y0.29
UCECchr652266685Missense_MutationnovelR695H0.42
UCECchr652283347SilentnovelR46R0.38
UCECchr652276470Missense_Mutationrs146513110R391H0.51
UCECchr652282661Missense_MutationnovelV131A0.09
UCECchr652279501Silentrs112388885A210A0.26
UCECchr652266122Missense_MutationnovelD727E0.48
UCECchr652267873Missense_MutationNAK688N0.24
UCECchr652278848Missense_MutationnovelT258N0.05
UCECchr652282691Missense_MutationnovelL121H0.49
UCECchr652267937Missense_MutationNAR667Q0.11
UCECchr652273835SilentNAL486L0.32
UCECchr652278811Missense_MutationNAK270N0.51
UCECchr652282774Missense_MutationNAK93N0.46
UCECchr652277161Silentrs770923814Y357Y0.35
UCECchr652276336Missense_MutationnovelA436T0.41
UCECchr652273859Nonsense_MutationnovelR478*0.28
UCECchr652279476Missense_Mutationrs201702015V219I0.36
UCECchr652282163Missense_Mutationrs752149151R138H0.46
UCECchr652282768SilentnovelY95Y0.27
UCECchr652266127Missense_MutationNAA726T0.07
UCECchr652266668Missense_MutationnovelD701N0.34
UCECchr652283356SilentnovelN43N0.22
UCECchr652282106Missense_Mutationrs778687751R157Q0.47
UCECchr652269167SilentnovelA629A0.35
UCECchr652276403Missense_MutationnovelK413N0.46
UCECchr6522645873'UTRnovel0.22
UCECchr652276386Missense_Mutationrs758287245R419H0.14
UCECchr652282075SilentnovelA167A0.11
UCECchr652279445Missense_MutationnovelA229V0.38
UCECchr652273894Missense_MutationnovelM466T0.38
UCECchr652282798SilentnovelA85A0.14
UCECchr6522644703'UTRnovel0.5
UCECchr652266653Missense_MutationNAD706N0.25
UCECchr6522643833'UTRnovel0.4
UCECchr652283346SilentnovelL47L0.18
UCECchr652282149Missense_MutationnovelR143S0.45
UCECchr652273819Missense_MutationNAP491H0.37
UCECchr652277141Missense_Mutationrs150139384R364Q0.4
UCECchr652279436Missense_MutationnovelG232D0.51
UCECchr6522847405'UTRnovel0.48
UCSchr652278807Missense_MutationnovelA272S0.07
UCSchr652273902SilentnovelK463K0.3

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
KIRPDEL0.08330.11427

Survival Analysis
CancerP-value Q-value
THYM0.0019

Kaplan-Meier Survival Analysis

STAD0.012

Kaplan-Meier Survival Analysis

SARC0.00049

Kaplan-Meier Survival Analysis

MESO0.014

Kaplan-Meier Survival Analysis

ACC0.00016

Kaplan-Meier Survival Analysis

KIRP0.012

Kaplan-Meier Survival Analysis

PCPG0.037

Kaplan-Meier Survival Analysis

BLCA0.034

Kaplan-Meier Survival Analysis

CESC0.0015

Kaplan-Meier Survival Analysis

READ0.028

Kaplan-Meier Survival Analysis

LAML0.018

Kaplan-Meier Survival Analysis

KICH0.00059

Kaplan-Meier Survival Analysis

UCEC0.023

Kaplan-Meier Survival Analysis

LIHC0.00018

Kaplan-Meier Survival Analysis

DLBC0.035

Kaplan-Meier Survival Analysis

LGG0.00011

Kaplan-Meier Survival Analysis

THCA0.0084

Kaplan-Meier Survival Analysis

OV0.0045

Kaplan-Meier Survival Analysis

Drugs

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Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBPome
  • Literatures
  • Expression
  • Transcripts
  • Gene Model
  • Pathways
  • Phenotypes
  • GWAS
  • PPI
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000112118 (Gene tree)
Gene ID
4172
Gene Symbol
MCM3
Alias
N
Full Name
minichromosome maintenance complex component 3
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Minus strand
Length
20,873 bases
Position
chr6:52,264,009-52,284,881
Accession
6945
RBP type
non-canonical RBP
Summary
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein is a subunit of the protein complex that consists of MCM2-7. It has been shown to interact directly with MCM5/CDC46. This protein also interacts with and is acetylated by MCM3AP, a chromatin-associated acetyltransferase. The acetylation of this protein inhibits the initiation of DNA replication and cell cycle progression. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2018]
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & HEK2932019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & HEK2932018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
29431736Capturing the interactome of newly transcribed RNAPolyT-RICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
29431736Capturing the interactome of newly transcribed RNARICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & Hela2018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & U2OS2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30352994Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome captureRIC & Jurkat2018 Oct 23Perez-Perri JIDOI:10.1038/s41467-018-06557-8

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
12885157Involvement of GANP in B cell activation in T cell-dependent antigen response.Dev Immunol2002 SepSakaguchi N-
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000421471MCM3-2031030-ENSP00000407651328 (aa)-Q7Z6P5
ENST00000476448MCM3-204982--- (aa)--
ENST00000596983MCM3-206559-ENSP0000047005777 (aa)-M0QYS9
ENST00000596288MCM3-2053169-ENSP00000472940853 (aa)-P25205
ENST00000419835MCM3-2022523-ENSP00000388647818 (aa)-J3KQ69
ENST00000616552MCM3-2073208-ENSP00000480987853 (aa)-P25205
ENST00000229854MCM3-2013083-ENSP00000229854808 (aa)-P25205
Gene Model
Click here to download ENSG00000112118's gene model file
Pathways
Pathway IDPathway NameSource
hsa03030DNA replicationKEGG
hsa04110Cell cycleKEGG
Phenotypes
ensgIDTraitpValuePubmed ID
ENSG00000112118Alanine Transaminase7.551e-005-
ENSG00000112118Alanine Transaminase7.551e-005-
ENSG00000112118Child Development Disorders, Pervasive1.1476000E-005-
ENSG00000112118Child Development Disorders, Pervasive4.0056000E-006-
ENSG00000112118Carcinoma, squamous cell of head and neck3E-627670397
ENSG00000112118Pain3E-627670397
GWAS
ensgIDSNPChromosomePositionSNP-risk TraitPubmedID95% CIOr or BEAT EFO ID
ENSG00000112118rs3789775652270696APre-treatment pain in head and neck squamous cell carcinoma27670397[1.40-2.30]1.8EFO_0003843|EFO_0000181
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000112118's network

* RBP PPI network refers to all genes directly bind to RBP
Orthologs identified by RBPome
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000112118MCM37932.985WBGene00003157mcm-58433.084Caenorhabditis_elegans
ENSG00000112118MCM38530.606FBgn0017577Mcm58531.390Drosophila_melanogaster
ENSG00000112118MCM37833.236FBgn0020633Mcm78633.382Drosophila_melanogaster
ENSG00000112118MCM36837.324ENSG00000166508MCM77640.257Homo_sapiens
ENSG00000112118MCM37931.060ENSG00000076003MCM67930.835Homo_sapiens
ENSG00000112118MCM38231.878ENSG00000100297MCM58132.767Homo_sapiens
ENSG00000112118MCM310092.638ENSMUSG00000041859Mcm310092.638Mus_musculus
ENSG00000112118MCM37137.005ENSMUSG00000029730Mcm77037.367Mus_musculus
ENSG00000112118MCM38149.858YEL032W7149.858Saccharomyces_cerevisiae
ENSG00000112118MCM38031.171YLR274WMCM58631.786Saccharomyces_cerevisiae
ENSG00000112118MCM36732.792YGL201C5533.061Saccharomyces_cerevisiae
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0000082G1/S transition of mitotic cell cycle-TASProcess
GO:0000784nuclear chromosome, telomeric region19135898.HDAComponent
GO:0003677DNA binding-IEAFunction
GO:0004386helicase activity-IEAFunction
GO:0005515protein binding12364596.15232106.16899510.17296731.19150984.19862764.22540012.24299456.25036637.26167883.26496610.29395061.IPIFunction
GO:0005524ATP binding-IEAFunction
GO:0005634nucleus20531406.21383955.IDAComponent
GO:0005654nucleoplasm-IDAComponent
GO:0005654nucleoplasm-TASComponent
GO:0005658alpha DNA polymerase:primase complex1549468.TASComponent
GO:0005730nucleolus21383955.IDAComponent
GO:0005813centrosome-IDAComponent
GO:0006260DNA replication-TASProcess
GO:0006270DNA replication initiation-IEAProcess
GO:0016020membrane19946888.HDAComponent
GO:0042555MCM complex17296731.IDAComponent
GO:0048471perinuclear region of cytoplasm20531406.IDAComponent
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