EuRBPDB

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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
22752059Identification of novel molecular targets regulated by tumor suppressive miR-375 induced by histone acetylation in esophageal squamous cell carcinoma.Int J Oncol2012 SepIsozaki Ydoi: 10.3892/ijo.2012.1537
27485076Use of LDH and autoimmune side effects to predict response to ipilimumab treatment.Immunotherapy2016 SepDick Jdoi: 10.2217/imt-2016-0083.
23437403Lactate dehydrogenase-B is silenced by promoter methylation in a high frequency of human breast cancers.PLoS One2013Brown NJdoi: 10.1371/journal.pone.0057697
25524555Oxamate-mediated inhibition of lactate dehydrogenase induces protective autophagy in gastric cancer cells: involvement of the Akt-mTOR signaling pathway.Cancer Lett2015 Mar 1Zhao Zdoi: 10.1016/j.canlet.2014.11.046
23224736Lactate dehydrogenase B is required for the growth of KRAS-dependent lung adenocarcinomas.Clin Cancer Res2013 Feb 15McCleland MLdoi: 10.1158/1078-0432.CCR-12-2638
21356207Decreased lactate dehydrogenase B expression enhances claudin 1-mediated hepatoma cell invasiveness via mitochondrial defects.Exp Cell Res2011 May 1Kim JHdoi: 10.1016/j.yexcr.2011.02.011
23697991Lactate dehydrogenase B: a metabolic marker of response to neoadjuvant chemotherapy in breast cancer.Clin Cancer Res2013 Jul 1Dennison JBdoi: 10.1158/1078-0432.CCR-13-0623
23139210An integrated genomic screen identifies LDHB as an essential gene for triple-negative breast cancer.Cancer Res2012 Nov 15McCleland MLdoi: 10.1158/0008-5472.CAN-12-1098

Differential Expression

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
BLCAchr1221635550Missense_MutationnovelD333H0.06
BLCAchr1221646995Missense_MutationnovelL51V0.45
BRCAchr1221637158Missense_MutationnovelN250K0.13
CESCchr1221637182SilentNAV242V0.24
CESCchr12216354883'UTRrs7658954570.34
CESCchr1221642122Missense_MutationnovelD142G0.43
CESCchr1221643936Splice_RegionnovelP140P0.46
CESCchr1221646939SilentnovelG69G0.44
COADchr1221646964Missense_MutationnovelG61E0.16
COADchr1221642074Missense_Mutationrs200163319R158H0.18
COADchr1221644058Missense_Mutationrs759971220R100C0.23
COADchr1221635542Nonstop_Mutationnovel*335Cext*70.09
COADchr1221638456Missense_MutationnovelG204C0.23
ESCAchr1221635638Silentrs765924083S303S0.38
ESCAchr1221638447Frame_Shift_DelnovelN206Wfs*90.11
GBMchr1221646920Missense_MutationnovelP76T0.1
GBMchr12216354283'UTRnovel0.07
HNSCchr1221638411Missense_MutationNAM219V0.33
HNSCchr1221641992SilentnovelS185S0.2
LAMLchr1221643974Missense_MutationnovelY128H0.14
LGGchr1221637133Missense_Mutationrs762586092D259N0.42
LIHCchr1221646913Missense_MutationnovelI78S0.29
LUADchr1221635565Nonsense_MutationNAQ328*0.78
LUADchr1221635575Silentrs769013947L324L0.19
LUADchr1221635559Missense_MutationnovelD330Y0.14
LUADchr1221654569Missense_MutationNAA35S0.21
LUADchr1221642122Missense_MutationnovelD142G0.41
LUSCchr12216355003'UTRnovel0.18
LUSCchr1221635680SilentNAF289F0.23
LUSCchr1221635707Splice_RegionNAG280G0.21
LUSCchr1221637151Missense_Mutationrs373042868I253V0.33
LUSCchr1221642017Missense_MutationNAE177V0.22
LUSCchr12216354083'UTRnovel0.07
LUSCchr1221644036Missense_MutationNAR107P0.25
OVchr1221635625Missense_MutationnovelK308Q0.1
OVchr1221643975Missense_MutationNAK127N0.33
PAADchr1221642072Missense_Mutationrs774614448V159M0.18
PRADchr1221637163Missense_MutationnovelT249A0.32
READchr1221637074Frame_Shift_InsnovelM281Dfs*50.09
READchr1221637076Missense_MutationNAV278L0.1
READchr12216354393'UTRnovel0.22
READchr1221638367Missense_MutationnovelK233N0.41
READchr1221642044Missense_MutationnovelS168Y0.45
SARCchr1221647014Splice_SitenovelX44_splice0.26
SKCMchr1221654606SilentNAN22N0.31
SKCMchr1221646958Missense_MutationnovelM63T0.36
SKCMchr1221644102Missense_MutationNAS85F0.41
SKCMchr1221654604Missense_MutationNAK23R0.2
STADchr1221654573SilentNAG33G0.21
STADchr1221635651Missense_Mutationrs753313189R299Q0.14
STADchr1221644094Missense_Mutationrs145369309A88T0.21
STADchr1221637090Missense_MutationNAP273L0.31
STADchr12216355013'UTRnovel0.26
STADchr1221654623Missense_Mutationrs750649581A17T0.26
STADchr1221646967Missense_MutationnovelK60R0.13
STADchr1221654593Missense_MutationNAV27M0.11
UCECchr1221635710Splice_SitenovelX280_splice0.23
UCECchr1221642075Missense_Mutationrs532712842R158C0.33
UCECchr1221644078Missense_MutationNAV93A0.28
UCECchr1221642112Silentrs112045700T145T0.51
UCECchr1221646912Missense_MutationnovelI78M0.23
UCECchr1221637089Silentrs748636200P273P0.4
UCECchr1221654568Missense_MutationNAA35V0.47
UCECchr1221637169Nonsense_MutationnovelG247*0.54
UCECchr1221644109Splice_SitenovelX83_splice0.37
UCECchr1221635703Missense_MutationnovelY282H0.08
UCECchr1221654620Missense_MutationnovelT18A0.3
UCECchr1221637154Missense_MutationNAA252T0.35
UCECchr1221635692Missense_MutationnovelE285D0.2
UCECchr1221641949Splice_Regionnovel0.24
UCECchr1221635654Missense_MutationnovelA298V0.38
UCECchr1221637169Nonsense_MutationnovelG247*0.35
UCECchr1221654668Missense_MutationNAA2T0.06
UCECchr1221635651Missense_Mutationrs753313189R299Q0.19
UCECchr1221654591SilentnovelV27V0.3
UCECchr1221644090Missense_Mutationrs760127821N89S0.2
UCECchr1221644072Missense_MutationnovelV95A0.55
UCECchr12216353993'UTRnovel0.17
UCECchr1221635650SilentnovelR299R0.46
UCECchr1221637102Missense_MutationnovelS269F0.33

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
DLBCDEL0.08330.11856
PAADDEL0.10870.0019175
READDEL0.1030.064633
TGCTAMP0.94671.4729e-22
THYMAMP0.03250.24554

Survival Analysis
CancerP-value Q-value
THYM0.028

Kaplan-Meier Survival Analysis

SARC0.046

Kaplan-Meier Survival Analysis

MESO0.021

Kaplan-Meier Survival Analysis

HNSC0.0058

Kaplan-Meier Survival Analysis

SKCM0.021

Kaplan-Meier Survival Analysis

READ0.043

Kaplan-Meier Survival Analysis

GBM0.0042

Kaplan-Meier Survival Analysis

LIHC0.043

Kaplan-Meier Survival Analysis

LUAD0.0039

Kaplan-Meier Survival Analysis

Drugs

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Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBPome
  • Literatures
  • Expression
  • Transcripts
  • Gene Model
  • Pathways
  • PPI
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000111716 (Gene tree)
Gene ID
3945
Gene Symbol
LDHB
Alias
N
Full Name
lactate dehydrogenase B
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Minus strand
Length
122,517 bases
Position
chr12:21,635,341-21,757,857
Accession
6541
RBP type
non-canonical RBP
Summary
This gene encodes the B subunit of lactate dehydrogenase enzyme, which catalyzes the interconversion of pyruvate and lactate with concomitant interconversion of NADH and NAD+ in a post-glycolysis process. Alternatively spliced transcript variants have been found for this gene. Recent studies have shown that a C-terminally extended isoform is produced by use of an alternative in-frame translation termination codon via a stop codon readthrough mechanism, and that this isoform is localized in the peroxisomes. Mutations in this gene are associated with lactate dehydrogenase B deficiency. Pseudogenes have been identified on chromosomes X, 5 and 13. [provided by RefSeq, Feb 2016]
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & HEK2932019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & HEK2932018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
29431736Capturing the interactome of newly transcribed RNANascentRICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
29431736Capturing the interactome of newly transcribed RNAPolyT-RICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
29431736Capturing the interactome of newly transcribed RNARICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & MCF10A2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & U2OS2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
27453046Comprehensive Identification of RNA-Binding Domains in Human CellsRIC & Hela2016 Aug 18Castello ADOI: 10.1016/j.molcel.2016.06.029

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
30136864Gordon H. Dixon's trace in my personal career and the quantic jump experienced in regulatory information.Syst Biol Reprod Med2018 DecMezquita-Pla Jdoi: 10.1080/19396368.2018.1503752
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000470280LDHB-205710--- (aa)--
ENST00000470985LDHB-206678--- (aa)--
ENST00000544151LDHB-210544--- (aa)--
ENST00000539782LDHB-208487-ENSP00000442680102 (aa)-F5H793
ENST00000450584LDHB-204732-ENSP00000398015136 (aa)-C9J7H8
ENST00000396075LDHB-202744XM_006719074ENSP00000379385232 (aa)XP_006719137A8MW50
ENST00000396076LDHB-2031538-ENSP00000379386334 (aa)-P07195
ENST00000542765LDHB-209672--- (aa)--
ENST00000535112LDHB-207252--- (aa)--
ENST00000350669LDHB-2011303-ENSP00000229319334 (aa)-P07195
Gene Model
Click here to download ENSG00000111716's gene model file
Pathways
Pathway IDPathway NameSource
hsa00010Glycolysis / GluconeogenesisKEGG
hsa00270Cysteine and methionine metabolismKEGG
hsa00620Pyruvate metabolismKEGG
hsa00640Propanoate metabolismKEGG
hsa01100Metabolic pathwaysKEGG
hsa04922Glucagon signaling pathwayKEGG
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000111716's network

* RBP PPI network refers to all genes directly bind to RBP
Orthologs identified by RBPome
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000111716LDHB10097.904ENSMUSG00000030246Ldhb10097.904Mus_musculus
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0004459L-lactate dehydrogenase activity-IEAFunction
GO:0005515protein binding21044950.24725412.25416956.25910212.27622334.IPIFunction
GO:0005737cytoplasm16130169.TASComponent
GO:0005829cytosol-IDAComponent
GO:0005829cytosol-TASComponent
GO:0005975carbohydrate metabolic process-IEAProcess
GO:0006090pyruvate metabolic process-TASProcess
GO:0016020membrane19946888.HDAComponent
GO:0042802identical protein binding25416956.IPIFunction
GO:0045121membrane raft25204797.IDAComponent
GO:0055114oxidation-reduction process-IEAProcess
GO:0070062extracellular exosome19056867.20458337.23533145.HDAComponent
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