EuRBPDB

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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
12051920Minor structural changes in a mutated human melanoma antigen correspond to dramatically enhanced stimulation of a CD4+ tumor-infiltrating lymphocyte line.J Mol Biol2002 May 31Sundberg EJ-
27908734Triosephosphate isomerase 1 suppresses growth, migration and invasion of hepatocellular carcinoma cells.Biochem Biophys Res Commun2017 Jan 22Jiang Hdoi: 10.1016/j.bbrc.2016.11.156
20233700[Identification and expression of two new secretory proteins associated with prostate cancer].Yi Chuan2010 MarQian XL-
28489783Clinical significance and prognostic value of Triosephosphate isomerase expression in gastric cancer.Medicine (Baltimore)2017 MayChen Tdoi: 10.1097/MD.0000000000006865.

Differential Expression

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
BLCAchr1268704133'UTRnovel0.3
BLCAchr1268705033'UTRnovel0.12
BLCAchr126870268Missense_MutationnovelS249F0.17
BLCAchr126867554Silentrs375712848L33L0.29
BRCAchr126867546Nonsense_Mutationrs782622700Q31*0.36
BRCAchr126870114SilentNAQ240Q0.31
BRCAchr126870378Missense_MutationNAQ286K0.56
BRCAchr126869142Missense_MutationnovelG132R0.08
BRCAchr126868861Splice_Regionnovel0.22
CESCchr126869301Missense_MutationnovelG160E0.52
CESCchr1268705363'UTRnovel0.38
CESCchr126867554Silentrs375712848L33L0.49
COADchr126867598Missense_MutationNAG48E0.09
COADchr126867563Missense_Mutationrs782032967S36R0.38
COADchr126870318Frame_Shift_DelnovelG266Afs*430.16
COADchr126870345Missense_MutationNAK275E0.06
COADchr126869341Missense_MutationNAE173D0.22
GBMchr1268704673'UTRnovel0.2
GBMchr126868934SilentnovelV99V0.39
GBMchr1268708093'UTRnovel0.09
HNSCchr1268706593'UTRnovel0.2
HNSCchr126867571Missense_Mutationrs781891860A39V0.32
HNSCchr126870332SilentnovelG270G0.29
HNSCchr126870309Missense_MutationnovelD263N0.26
HNSCchr126867543Missense_Mutationrs781876590L30F0.35
KIRCchr1268704583'UTRNA0.47
KIRCchr126868893Missense_MutationNAI86V0.38
KIRPchr126867554Silentrs375712848L33L0.09
KIRPchr126867558Missense_MutationNAS35P0.47
KIRPchr1268703903'UTRnovel0.1
LGGchr126869151Missense_MutationnovelE135K0.45
LIHCchr126869104Missense_MutationnovelG119A0.06
LUADchr126869269Missense_MutationNAQ149H0.1
LUADchr126869368Missense_MutationNAF182L0.33
LUADchr126869689Splice_RegionNAD190D0.32
LUADchr126867563Silentrs782032967S36S0.21
LUADchr126867562Missense_MutationnovelS36T0.14
LUADchr126867651Missense_MutationNAL66V0.25
LUADchr126870339Missense_MutationnovelS273T0.28
LUADchr126870340Missense_MutationnovelS273Y0.28
LUSCchr126870382Silentnovel*287*0.26
LUSCchr126870124Missense_MutationNAI244V0.36
LUSCchr126870324Missense_MutationNAL268F0.38
LUSCchr126867644SilentNAI63I0.06
LUSCchr126869287SilentnovelL155L0.04
OVchr126870063Silentrs369241009H223H0.11
OVchr1268706163'UTRnovel0.55
PAADchr126867672Missense_MutationnovelA73T0.21
PAADchr126870364Missense_MutationnovelI281S0.14
PCPGchr126867565Missense_MutationnovelA37V0.29
PRADchr1268704123'UTRnovel0.32
SKCMchr1268706293'UTRnovel0.67
SKCMchr126869299Silentrs138131191L159L0.41
SKCMchr126869709Missense_MutationNAK197T0.16
SKCMchr1268704933'UTRnovel0.25
SKCMchr1268703913'UTRrs7827896970.11
STADchr126869714Missense_Mutationrs782391534V199I0.24
STADchr126869121Missense_MutationnovelG125R0.12
STADchr1268704173'UTRnovel0.23
UCECchr1268705133'UTRnovel0.43
UCECchr126869129SilentnovelT127T0.19
UCECchr126870290Missense_MutationnovelK256N0.28
UCECchr1268706423'UTRnovel0.32
UCECchr1268707893'UTRnovel0.3
UCECchr126870104Missense_Mutationrs139532537A237V0.25
UCECchr126869172Missense_MutationNAE142K0.3
UCECchr126870356Missense_MutationnovelF278L0.36
UCECchr126869278SilentnovelA152A0.51
UCECchr126870104Missense_Mutationrs139532537A237V0.29
UCECchr1268705113'UTRnovel0.28
UCECchr1268706923'UTRnovel0.55
UCECchr1268707883'UTRnovel0.3
UCECchr1268707183'UTRrs7825217740.17
UCECchr1268706923'UTRnovel0.36
UCECchr126869387Missense_MutationnovelA189T0.43
UCECchr126870122Missense_Mutationrs782417309R243H0.38
UCECchr126869757Missense_MutationNAT213N0.27
UCECchr126870310Missense_Mutationrs750196839D263G0.19
UCECchr126869368Silentrs781865717F182F0.26

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
COADDEL0.07540.087189
DLBCDEL0.10420.11856
MESODEL0.08050.17495
PAADDEL0.1250.0019175
READDEL0.1030.064633
TGCTAMP0.94673.5918e-21
THYMAMP0.03250.24554

Survival Analysis
CancerP-value Q-value
SARC0.0032

Kaplan-Meier Survival Analysis

MESO0.0039

Kaplan-Meier Survival Analysis

ACC0.0012

Kaplan-Meier Survival Analysis

HNSC0.012

Kaplan-Meier Survival Analysis

SKCM0.00013

Kaplan-Meier Survival Analysis

ESCA0.0075

Kaplan-Meier Survival Analysis

BLCA0.026

Kaplan-Meier Survival Analysis

CESC0.013

Kaplan-Meier Survival Analysis

LAML0.00034

Kaplan-Meier Survival Analysis

KICH0.0013

Kaplan-Meier Survival Analysis

LIHC0.0001

Kaplan-Meier Survival Analysis

DLBC0.025

Kaplan-Meier Survival Analysis

CHOL0.04

Kaplan-Meier Survival Analysis

LUAD0.0003

Kaplan-Meier Survival Analysis

UVM0.0011

Kaplan-Meier Survival Analysis

Drugs

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Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBPome
  • Literatures
  • Expression
  • Transcripts
  • Gene Model
  • Pathways
  • PPI
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000111669 (Gene tree)
Gene ID
7167
Gene Symbol
TPI1
Alias
N
Full Name
triosephosphate isomerase 1
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Plus strand
Length
3,830 bases
Position
chr12:6,867,119-6,870,948
Accession
12009
RBP type
non-canonical RBP
Summary
This gene encodes an enzyme, consisting of two identical proteins, which catalyzes the isomerization of glyceraldehydes 3-phosphate (G3P) and dihydroxy-acetone phosphate (DHAP) in glycolysis and gluconeogenesis. Mutations in this gene are associated with triosephosphate isomerase deficiency. Pseudogenes have been identified on chromosomes 1, 4, 6 and 7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009]
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & HEK2932019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & MCF10A2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & U2OS2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
29463416Irradiation of rainbow trout at early life stages results in a proteomic legacy in adult gills. Part A; proteomic responses in the irradiated fish and in non-irradiated bystander fish.Environ Res2018 MaySmith RWdoi: 10.1016/j.envres.2017.12.023
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000396705TPI1-2021231-ENSP00000379933249 (aa)-P60174
ENST00000495834TPI1-208820-ENSP0000047582998 (aa)-U3KQF3
ENST00000229270TPI1-2011763-ENSP00000229270286 (aa)-P60174
ENST00000613953TPI1-2101460-ENSP00000484435286 (aa)-P60174
ENST00000488464TPI1-206791-ENSP00000475620167 (aa)-P60174
ENST00000462761TPI1-203374-ENSP0000047518438 (aa)-U3KPS5
ENST00000493987TPI1-207839-ENSP00000475364113 (aa)-U3KPZ0
ENST00000482209TPI1-205328--- (aa)--
ENST00000535434TPI1-2091587-ENSP00000443599167 (aa)-P60174
ENST00000474253TPI1-204427--- (aa)--
Gene Model
Click here to download ENSG00000111669's gene model file
Pathways
Pathway IDPathway NameSource
hsa00010Glycolysis / GluconeogenesisKEGG
hsa00051Fructose and mannose metabolismKEGG
hsa00562Inositol phosphate metabolismKEGG
hsa01100Metabolic pathwaysKEGG
hsa01200Carbon metabolismKEGG
hsa01230Biosynthesis of amino acidsKEGG
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000111669's network

* RBP PPI network refers to all genes directly bind to RBP
Orthologs identified by RBPome
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000111669TPI19575.000WBGene00006601tpi-19962.195Caenorhabditis_elegans
ENSG00000111669TPI110071.053FBgn0086355Tpi9964.634Drosophila_melanogaster
ENSG00000111669TPI110098.230ENSMUSG00000023456Tpi110097.605Mus_musculus
ENSG00000111669TPI19958.763YDR050C9953.036Saccharomyces_cerevisiae
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0004807triose-phosphate isomerase activity21873635.IBAFunction
GO:0004807triose-phosphate isomerase activity18562316.IDAFunction
GO:0004807triose-phosphate isomerase activity2876430.NASFunction
GO:0004807triose-phosphate isomerase activity2579079.TASFunction
GO:0005515protein binding20849852.21044950.23355646.IPIFunction
GO:0005615extracellular space16502470.22664934.23580065.HDAComponent
GO:0005634nucleus21630459.HDAComponent
GO:0005829cytosol21873635.IBAComponent
GO:0005829cytosol-TASComponent
GO:0006094gluconeogenesis21873635.IBAProcess
GO:0006094gluconeogenesis-IEAProcess
GO:0006094gluconeogenesis-TASProcess
GO:0006096glycolytic process21873635.IBAProcess
GO:0007275multicellular organism development-IEAProcess
GO:0008929methylglyoxal synthase activity-ISSFunction
GO:0019242methylglyoxal biosynthetic process-ISSProcess
GO:0019563glycerol catabolic process21873635.IBAProcess
GO:0031625ubiquitin protein ligase binding19725078.IPIFunction
GO:0042803protein homodimerization activity18562316.IDAFunction
GO:0046166glyceraldehyde-3-phosphate biosynthetic process21873635.IBAProcess
GO:0046166glyceraldehyde-3-phosphate biosynthetic process18562316.IDAProcess
GO:0061621canonical glycolysis-TASProcess
GO:0070062extracellular exosome19056867.23533145.HDAComponent
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